CN110840853A - Chewing or buccal type oropharyngeal local anesthetic for gastroscopy and taking method - Google Patents

Chewing or buccal type oropharyngeal local anesthetic for gastroscopy and taking method Download PDF

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Publication number
CN110840853A
CN110840853A CN201911026881.3A CN201911026881A CN110840853A CN 110840853 A CN110840853 A CN 110840853A CN 201911026881 A CN201911026881 A CN 201911026881A CN 110840853 A CN110840853 A CN 110840853A
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CN
China
Prior art keywords
chewing
local anesthetic
gastroscopy
oropharyngeal
anesthetic
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Pending
Application number
CN201911026881.3A
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Chinese (zh)
Inventor
张强
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Individual
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Individual
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Publication date
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Priority to CN201911026881.3A priority Critical patent/CN110840853A/en
Publication of CN110840853A publication Critical patent/CN110840853A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a chewable oropharyngeal local anesthetic for gastroscopy, which is a pill prepared from 0.5-10% of local anesthetic, gum or an elastomer, and syrup or a sweetening agent. The invention also discloses a method for taking the chewing oropharyngeal local anesthetic for gastroscopy. The chewing oropharyngeal local anesthetic for gastroscopy and the taking method thereof provided by the invention have the advantages that the formula, the dosage form and the taking mode of the medicine are changed, so that the anesthetic fully permeates through the oropharyngeal mucosa, a good local anesthetic effect is achieved, and the sweet taste can be easily accepted by patients.

Description

Chewing or buccal type oropharyngeal local anesthetic for gastroscopy and taking method
Technical Field
The invention relates to a chewing type or buccal local anesthetic for gastroscopy and a taking method thereof.
Background
Gastroscopy is the most effective method for screening upper gastrointestinal tumors, which has been recognized and popularized worldwide. Because, in the process of gastroscopy, repeated stimulation of the endoscope body to the oral cavity and the throat part leads to pharyngeal radiation, which not only influences the effect of the gastroscopy, but also leads the patient to fear to receive the gastroscopy, thereby delaying the illness state. Currently, prior to daily gastroscopy, lidocaine mucilage is usually orally taken to perform local anesthesia on the oropharynx so as to reduce the sensitivity of the oropharynx to external stimuli and increase the comfort level of the gastroscopy. However, the lidocaine mucilage is poor in oral administration effect, the residence time of the medicine in the oropharynx is short, the oropharynx mucosa cannot be sufficiently anesthetized, and the bitter taste of the medicine makes patients have resistance.
Disclosure of Invention
One of the purposes of the invention is to provide a chewing oropharyngeal local anesthetic for gastroscopy, which can fully permeate anesthetic on oropharyngeal mucosa by changing the formula and dosage form of the medicine, thereby achieving good local anesthetic effect and enabling the patient to accept sweet taste.
The invention also aims to provide a method for taking the chewing oropharyngeal local anesthetic for gastroscopy, which adopts a mode of not swallowing by chewing to ensure that the anesthetic stays in the oropharyngeal part for a longer time, thereby fully permeating the oropharyngeal mucosa and achieving a good local anesthetic effect.
The invention also aims to provide a chewing or buccal oropharyngeal local anesthetic for gastroscopy, which can fully permeate the anesthetic on the oropharyngeal mucosa by changing the medicament formula and the medicament form, thereby achieving good local anesthetic effect and leading the sweet taste to be more easily accepted by patients.
The fourth purpose of the invention is to provide a method for taking chewing or buccal type oropharyngeal local anesthesia for gastroscopy, which adopts a mode of chewing melting or buccal melting and swallowing to ensure that the anesthesia medicine stays for a longer time in the oropharyngeal part, thereby fully permeating the oropharyngeal mucosa and achieving good local anesthesia effect.
In order to achieve the above object, the present invention provides a chewable oropharyngeal site anesthetic for gastroscopy, comprising: 0.5-10% of local anesthetic, gum or an elastomer, syrup or a sweetener.
As a further development of the invention, the gum is a natural or synthetic gum.
In order to achieve the second object, the present invention provides a method for administering a chewable oropharyngeal site anesthetic for gastroscopy, the method comprising: placing a pill in oral cavity, slowly chewing, and spitting out when mouth and throat feel numbness, and can not be swallowed, or increasing the number of pills if the anesthesia effect is poor after chewing.
In order to achieve the third object, the present invention provides a chewable oropharyngeal site anesthetic for gastroscopy, comprising: 0.5-10% of local anesthetic, glycerol, starch, dextrin, lactose, mannitol, xylitol, citric acid, carboxymethyl starch sodium and hydroxypropyl methylcellulose or magnesium stearate.
In order to achieve the fourth object, the present invention provides a method for administering a chewing or buccal type oropharyngeal local anesthetic for gastroscopy, the method comprising: placing a pill in oral cavity, slowly chewing to melt or contain, without spitting, and increasing the number of pills if the anesthetic effect is poor.
Compared with the prior art, the chewing or buccal oropharyngeal local anesthetic for gastroscopy and the taking method thereof have the following beneficial effects:
(1) the anesthetic can fully permeate in the mucous membrane of the oropharynx by changing the formula, the dosage form and the administration mode of the medicine, thereby achieving good local anesthesia effect and being easily accepted by patients with various selectable tastes.
(2) The chewing or buccal mode can prolong the release time of local anesthetic in oropharynx, and promote drug penetration.
(3) The addition of different auxiliary materials can change the taste of the local anesthetic, so that the pill can be made into different tastes, such as orange taste, banana taste and the like, and is convenient to accept.
Detailed Description
Example one
The chewing oropharyngeal local anesthetic for gastroscopy is a pill prepared from 0.5-10% of local anesthetic, gum or an elastomer, syrup or a sweetening agent. The local anesthetic is lidocaine, procaine, bupivacaine or tetracaine. The gum is a natural or synthetic gum.
The administration method comprises placing one pill in oral cavity, slowly chewing for 15 min, and spitting out when the mouth and throat feel numbness, and can not be swallowed, and if the anesthesia effect is poor after chewing for 15 min, increasing the number of pills, and the number of pills can be at least one.
Example two
The chewing or buccal type oropharyngeal local anesthetic for gastroscopy is a pill prepared from 0.5-10% of local anesthetic, glycerol, starch, dextrin, lactose, mannitol, xylitol, citric acid, carboxymethyl starch sodium and hydroxypropyl methyl cellulose or magnesium stearate. The local anesthetic is lidocaine, procaine, bupivacaine or tetracaine.
The administration method comprises placing one pill in oral cavity, slowly chewing to melt or contain, without spitting out, and adding at least one pill if the anesthetic effect is poor.
The present invention has been described in connection with the preferred embodiments, but the present invention is not limited to the embodiments disclosed above, and is intended to cover various modifications, equivalent combinations, which are made in accordance with the spirit of the present invention.

Claims (5)

1. A chewing oropharyngeal local anesthetic for gastroscopy is characterized by comprising: 0.5-10% of local anesthetic, gum or an elastomer, syrup or a sweetener.
2. The chewable oropharyngeal local anesthetic for gastroscopy according to claim 1, characterized in that: the gum is a natural or synthetic gum.
3. A method of administering a chewable oropharyngeal local anesthetic for gastroscopy according to claim 1, characterized in that it comprises: placing a pill in oral cavity, slowly chewing, and spitting out when mouth and throat feel numbness, and can not be swallowed, or increasing the number of pills if the anesthesia effect is poor after chewing.
4. A chewing or buccal type oropharyngeal local anesthetic for gastroscopy is characterized by comprising: 0.5-10% of local anesthetic, glycerol, starch, dextrin, lactose, mannitol, xylitol, citric acid, carboxymethyl starch sodium and hydroxypropyl methylcellulose or magnesium stearate.
5. A method of administering a chewing or buccal type oropharyngeal anesthetic for gastroscopy according to claim 4, characterized in that the method of administration comprises: placing a pill in oral cavity, slowly chewing to melt or contain, without spitting, and increasing the number of pills if the anesthetic effect is poor.
CN201911026881.3A 2019-10-26 2019-10-26 Chewing or buccal type oropharyngeal local anesthetic for gastroscopy and taking method Pending CN110840853A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201911026881.3A CN110840853A (en) 2019-10-26 2019-10-26 Chewing or buccal type oropharyngeal local anesthetic for gastroscopy and taking method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201911026881.3A CN110840853A (en) 2019-10-26 2019-10-26 Chewing or buccal type oropharyngeal local anesthetic for gastroscopy and taking method

Publications (1)

Publication Number Publication Date
CN110840853A true CN110840853A (en) 2020-02-28

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Family Applications (1)

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Country Status (1)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1349418A (en) * 1999-05-05 2002-05-15 雷克特本克斯尔保健(英国)有限公司 Compositions for treatment of disorders of the oesophagus
CN1626164A (en) * 2003-12-09 2005-06-15 上海第二医科大学 Gel for local anesthesia and analgesia on surface of skin, and usage
CN1698790A (en) * 2005-05-27 2005-11-23 北京阜康仁生物制药科技有限公司 Gastrodia tuber preparation and its preparing process
CN101322848A (en) * 2008-07-28 2008-12-17 上海艾韦特医药科技有限公司 Composition for gastroscopy and preparation thereof
CN109908205A (en) * 2019-03-06 2019-06-21 陕西军兴生物医药科技有限公司 A kind of drug prevented or treat mouth disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1349418A (en) * 1999-05-05 2002-05-15 雷克特本克斯尔保健(英国)有限公司 Compositions for treatment of disorders of the oesophagus
CN1626164A (en) * 2003-12-09 2005-06-15 上海第二医科大学 Gel for local anesthesia and analgesia on surface of skin, and usage
CN1698790A (en) * 2005-05-27 2005-11-23 北京阜康仁生物制药科技有限公司 Gastrodia tuber preparation and its preparing process
CN101322848A (en) * 2008-07-28 2008-12-17 上海艾韦特医药科技有限公司 Composition for gastroscopy and preparation thereof
CN109908205A (en) * 2019-03-06 2019-06-21 陕西军兴生物医药科技有限公司 A kind of drug prevented or treat mouth disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
马英主编: "《药物化学 第2版》", 31 August 2012, 河南科学技术出版社 *

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Application publication date: 20200228

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