CN110840473B - Bone mineral density measuring system based on CT thin-layer scanning Hu value - Google Patents
Bone mineral density measuring system based on CT thin-layer scanning Hu value Download PDFInfo
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- CN110840473B CN110840473B CN201911156406.8A CN201911156406A CN110840473B CN 110840473 B CN110840473 B CN 110840473B CN 201911156406 A CN201911156406 A CN 201911156406A CN 110840473 B CN110840473 B CN 110840473B
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- A—HUMAN NECESSITIES
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- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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Abstract
A bone density measurement system based on CT thin-layer scanning Hu value comprises a data acquisition module, a data processing module, a three-dimensional reconstruction module, a region dividing module, a measurement module and a calculation module; the data acquisition module acquires thin CT data, transmits the thin CT data to the data processing module for correction and inspection, and then transmits the thin CT data to the three-dimensional reconstruction module for three-dimensional surface reconstruction; the region dividing module is used for dividing the region of the CT data after three-dimensional reconstruction to distinguish cortical bone, muscle and fat; the measurement module is used for measuring Hu values of cancellous bone, muscle and fat in cortical bone; the calculation module calculates an improved Hu value based on Hu values of cancellous bone, muscle, and fat within cortical bone. The system performs secondary analysis on the existing CT data, obtains an improved Hu value by measuring and calculating the cancellous bone Hu value, the fat Hu value and the muscle Hu value, reduces measurement errors, has low cost and convenient use, and is beneficial to wide popularization.
Description
Technical Field
The invention relates to the technical field of medical image processing, in particular to a bone density measurement system based on CT thin-layer scanning Hu value.
Background
With the increase of life expectancy of the population, the proportion of the aged population over 65 years to the general population of the society is gradually increased, and the occurrence rate of osteoporosis in the aged is increased from 14.94% to 27.96%, and patients suffering from osteoporosis may cause pathological bone mass, thereby leading to long-term bedridden. Osteoporosis has become a serious social problem.
And many spinal surgery patients are also because of older age, the reason of osteoporosis can lead to the phenomena of unstable fixation of the spinal column, delayed fusion and even unfused fusion, and the health is affected.
Although diagnostic techniques are now continually advancing, the detected cases of osteoporosis remain low.
The methods of diagnosing osteoporosis recommended by WHO are DXA and QCT, wherein the principle of DXA (dual X-ray absorptiometry) is to directly check the X-ray absorption and then convert the data into area density (g/cm 2), but since DXA belongs to a planar measurement method, it contains cortical bone, so the measurement error is still about 20%, and thus the current use rate of DXA is still not high.
QCT quantitative QCT was invented in the last practical 70 s, mostly by performing density reference by a special phantoms, and then calculating bone density volume BMD (g/cm 3) or area BMD (g/cm 2) by software, but additional operations are needed to obtain the final bone density value. And special phantom and software add extra burden to patients, and the application range is not very wide.
Moreover, when the Hu value is measured by the method, the Hu value can not truly and effectively reflect the bone density due to the influence of external factors such as voltage conditions, table height, scanning layer thickness and the like.
Disclosure of Invention
The invention mainly aims at the problems of large error, high cost, low popularity and use ratio of the bone density measurement mode, and the like, and provides a bone density measurement system based on CT thin-layer scanning Hu value, which performs secondary analysis on the existing CT data, obtains improved Hu value by measuring and calculating cancellous bone Hu value, fat Hu value and muscle Hu value, reduces measurement error, has low cost and convenient use, and is beneficial to wide popularization.
The technical scheme of the invention is as follows:
a bone density measurement system based on CT thin-layer scanning Hu value comprises a data acquisition module, a data processing module, a three-dimensional reconstruction module, a region dividing module, a measurement module and a calculation module.
The data acquisition module comprises a thin layer chromatography scanner, the scanning layer distance is smaller than 5mm, thin layer CT data are acquired through the thin layer chromatography scanner, and the thin layer CT data are transmitted to the data processing module.
The data processing module corrects and checks the thin CT data, removes air values, corrects hardening effects and zero drift, and then transmits the thin CT data to the three-dimensional reconstruction module.
The three-dimensional reconstruction module performs three-dimensional surface reconstruction on the thin-layer CT data.
The region dividing module is used for dividing the region of the CT data after three-dimensional reconstruction to distinguish cortical bone, muscle and fat; the regional division module comprises an automatic division system and/or a manual division system, and can select the division mode according to the needs or select the automatic division firstly, and the manual division is used for correction after the automatic division is finished.
The measurement module measures Hu values for cancellous bone, muscle, and fat within cortical bone.
Further, the measurement module may measure Hu values of cancellous bone, muscle, and fat in cortical bone at one or more measurement locations and calculate respective average Hu values. Preferably, the measuring position comprises a circular measuring point, the diameter of the circular measuring point is larger than 5mm, and the average Hu value is convenient to select and obtain.
The calculation module comprehensively calculates an improved Hu value according to the Hu values of cancellous bone, muscle and fat in the cortical bone measured by the measurement module.
Further, the calculation module calculates the modified Hu value according to the following formula: (cancellous bone average Hu value-fat average Hu value)/(muscle average Hu value-fat average Hu value). Since the fat, muscle and bone density are increased or decreased simultaneously in the same CT result, the result of the improved Hu value is stable and can be used as an evaluation index of bone density at the measuring position.
The main purpose of the data acquisition module, the data processing module and the three-dimensional reconstruction module is to acquire three-dimensional reconstructed CT data of a patient, wherein the three-dimensional reconstructed CT data obtained by other modes of the patient can be directly used and directly transmitted to the region dividing module.
The bone density measurement system based on CT thin-layer scanning Hu value also comprises a comparison module, wherein the comparison module provides bone Hu values of different age stages and can provide reference for the improved Hu values obtained in the calculation module. The improved Hu values measured by the bone mineral density measurement system described above facilitate the creation of a uniform parameter to eliminate the differences between groups and calculate the optimal threshold for assessing osteoporosis. And the threshold value is used as an index for pathological fracture risk assessment of the elderly and perioperative assessment of the internal fixation operation of the spine.
The invention has the beneficial effects that:
1. the bone density measurement system based on CT thin-layer scanning Hu value disclosed by the invention performs secondary analysis on the existing CT data, obtains an improved Hu value by measuring and calculating the cancellous bone Hu value, the fat Hu value and the muscle Hu value, reduces measurement error, has low cost and convenient use, and is beneficial to wide popularization.
2. According to the bone density measurement system based on the CT thin-layer scanning Hu value, the improved Hu value obtained by measuring and calculating the cancellous bone Hu value, the fat Hu value and the muscle Hu value is stable in measured value, so that errors caused by CT scanning of different CT machines, different CT scanning parameters and different time periods can be eliminated, and the repeatability research of experiments can be facilitated.
3. According to the bone mineral density measuring system based on CT thin-layer scanning Hu value, a unified parameter can be made through the measured improved Hu value, so that differences among groups are eliminated, and an optimal threshold value for evaluating osteoporosis is calculated. And the threshold value is used as an index for pathological fracture risk assessment of the elderly and perioperative assessment of the internal fixation operation of the spine.
Drawings
The aspects and advantages of the present application will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention.
In the drawings:
FIG. 1 is a flow chart of a bone mineral density measurement system based on CT thin-layer scanning Hu value in embodiment 1;
fig. 2 is a measurement position diagram of the measurement module of the embodiment 1;
the components represented by the reference numerals in the figures are:
1. cancellous bone measurement area, 2, fat measurement area, 3, muscle measurement area.
Detailed Description
Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. It should be noted that these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art, and the disclosure may be embodied in various forms and should not be limited by the embodiments set forth herein.
Example 1
Referring to fig. 1, fig. 1 is a flow chart of a bone mineral density measurement system based on CT thin-layer scanning Hu value according to the present embodiment, which includes a data acquisition module, a data processing module, a three-dimensional reconstruction module, a region dividing module, a measurement module, a calculation module and a comparison module.
The present embodiment is based on CT data at the lumbar spine, and determines the patient's osteoporosis by detecting the cancellous bone Hu value at the spine.
Further, the data acquisition module adopts a thin layer chromatography scanner, the scanning layer distance is smaller than 5mm, thin layer CT data are acquired through the thin layer chromatography scanner, and the thin layer CT data are transmitted to the data processing module.
The data processing module corrects and checks the thin CT data, removes air values, corrects hardening effects and zero drift, and then transmits the thin CT data to the three-dimensional reconstruction module.
The three-dimensional reconstruction module performs three-dimensional surface reconstruction on the thin-layer CT data.
Of course, the main purpose of the data acquisition module, the data processing module and the three-dimensional reconstruction module of the system is to acquire CT data of a patient after three-dimensional reconstruction, and if the patient has CT data which is directly made, the CT data can also be directly taken and transmitted to the region dividing module for use. In addition, the patient in the spine operation needs to carry out conventional CT three-dimensional reconstruction before operation, and the system is mainly used for carrying out secondary analysis on CT data, so that the extra burden of the patient is not increased, and the cost of the patient can be saved.
Further, the region dividing module performs region division on the CT data after three-dimensional reconstruction to distinguish cortical bone, muscle and fat; the regional division module comprises an automatic division system and/or a manual division system, and can select the division mode according to the needs or select the automatic division firstly, and the manual division is used for correction after the automatic division is finished. In the embodiment, the cortical bone of the vertebral body is automatically defined by adopting computer image recognition software, and the inside of the cortical bone of the vertebral body is all cancellous bone.
Further, the measurement module measures Hu values for cancellous bone, muscle, and fat within cortical bone. Each measurement location includes one or more and then calculates a respective average Hu value. Preferably, the measuring position comprises a circular measuring point, the diameter of the circular measuring point is larger than 5mm, and the average Hu value is convenient to select and obtain. Referring specifically to fig. 2, wherein cancellous bone Hu values are measured in cancellous bone measurement zone 1, fat Hu values are measured in fat measurement zone 2, and muscle Hu values are measured in muscle measurement zone 3.
Further, the calculation module comprehensively calculates an improved Hu value according to the Hu values of cancellous bone, muscle and fat in the cortical bone measured by the measurement module. The specific calculation formula is as follows: (cancellous bone average Hu value-fat average Hu value)/(muscle average Hu value-fat average Hu value). The calculation formula synthesizes Hu values of cancellous bone, muscle and fat, and compared with the traditional method for directly measuring bone density, the improved Hu value is more accurate and stable. In the same CT result, the fat, muscle and bone density are increased or decreased synchronously, so the result of the improved Hu value is stable and can be used as the bone density evaluation index of the measuring position
In this embodiment, the calculation module is connected to a comparison module, and the comparison module provides the bone Hu values at different age stages, so as to provide a reference for the improved Hu values obtained in the calculation module. The improved Hu values measured by the bone mineral density measurement system described above facilitate the creation of a uniform parameter to eliminate the differences between groups and calculate the optimal threshold for assessing osteoporosis. And the threshold value is used as an index for pathological fracture risk assessment of the elderly and perioperative assessment of the internal fixation operation of the spine.
The present invention is not limited to the above-mentioned embodiments, and any changes or modifications within the scope of the present invention will be apparent to those skilled in the art. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (4)
1. The bone mineral density measuring system based on the thin-layer CT scanning Hu value is characterized by comprising a data acquisition module, a data processing module, a three-dimensional reconstruction module, a region dividing module, a measuring module and a calculating module;
the data acquisition module acquires thin layer CT data and transmits the thin layer CT data to the data processing module;
the data processing module corrects and checks the thin CT data, and then transmits the thin CT data to the three-dimensional reconstruction module;
the three-dimensional reconstruction module performs three-dimensional surface reconstruction on the thin-layer CT data;
the region dividing module is used for dividing the region of the CT data after three-dimensional reconstruction to distinguish cortical bone, muscle and fat;
the measurement module is used for measuring Hu values of cancellous bone, muscle and fat in cortical bone, wherein the measurement positions comprise a plurality of measurement positions, and then calculating respective average Hu values;
the measuring position comprises a circular measuring point, and the diameter of the circular measuring point is larger than 5mm;
the calculation module comprehensively calculates an improved Hu value according to the Hu values of cancellous bone, muscle and fat in the cortical bone, which are measured by the measurement module, specifically (cancellous bone average Hu value-fat average Hu value)/(muscle average Hu value-fat average Hu value).
2. The bone mineral density measurement system of claim 1, wherein the data acquisition module comprises a thin layer chromatography scanner.
3. The bone mineral density measurement system of claim 1, wherein the region segmentation module comprises an automatic segmentation system and/or a manual segmentation system.
4. A bone density measurement system based on CT thin layer scan Hu values according to any of claims 1-3, further comprising a comparison module providing bone Hu values at different age stages, capable of providing a reference for the modified Hu values obtained in the calculation module.
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| CN114782375B (en) * | 2022-04-27 | 2023-06-23 | 影图(成都)医疗科技有限公司 | Bone density measuring method, device and equipment |
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| JPH0599829A (en) * | 1991-10-04 | 1993-04-23 | Matsushita Electric Ind Co Ltd | Quantitative measurement method of substance |
| JPH07284020A (en) * | 1994-04-13 | 1995-10-27 | Hitachi Ltd | Bone density measuring method |
| CN103164592A (en) * | 2011-12-10 | 2013-06-19 | 西安百利信息科技有限公司 | Computer aided detection and remote consultation system of bone mineral density |
| CN103442638A (en) * | 2011-03-18 | 2013-12-11 | 日立阿洛卡医疗株式会社 | Bone density measurement device |
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| US6990222B2 (en) * | 2001-11-21 | 2006-01-24 | Arnold Ben A | Calibration of tissue densities in computerized tomography |
| US9198630B2 (en) * | 2013-12-18 | 2015-12-01 | Siemens Aktiengesellschaft | Method and computing unit for measuring and displaying the bone density of a patient |
| US20150348259A1 (en) * | 2014-06-03 | 2015-12-03 | Carestream Health, Inc. | Quantitative method for 3-d bone mineral density visualization and monitoring |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH0599829A (en) * | 1991-10-04 | 1993-04-23 | Matsushita Electric Ind Co Ltd | Quantitative measurement method of substance |
| JPH07284020A (en) * | 1994-04-13 | 1995-10-27 | Hitachi Ltd | Bone density measuring method |
| CN103442638A (en) * | 2011-03-18 | 2013-12-11 | 日立阿洛卡医疗株式会社 | Bone density measurement device |
| CN103164592A (en) * | 2011-12-10 | 2013-06-19 | 西安百利信息科技有限公司 | Computer aided detection and remote consultation system of bone mineral density |
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