CN110812222B - Automatic radioactive drug subpackaging instrument and method - Google Patents
Automatic radioactive drug subpackaging instrument and method Download PDFInfo
- Publication number
- CN110812222B CN110812222B CN201810925293.2A CN201810925293A CN110812222B CN 110812222 B CN110812222 B CN 110812222B CN 201810925293 A CN201810925293 A CN 201810925293A CN 110812222 B CN110812222 B CN 110812222B
- Authority
- CN
- China
- Prior art keywords
- activity
- peristaltic
- peristaltic pump
- bottle
- radioactivity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses an automatic radioactive drug subpackaging instrument and a subpackaging method thereof, belonging to the field of radioactive drug subpackaging; the split charging instrument comprises a peristaltic hose, an output needle and an input needle which are communicated with two ends of the peristaltic hose, a peristaltic pump for extruding the peristaltic hose and a box body for packaging the peristaltic pump, wherein the split charging method comprises the following steps: s1, inserting the output needle into the source liquid bottle and the input needle into the collection bottle, S2, starting the peristaltic pump to fill the peristaltic hose with the medicine to obtain the volume of the peristaltic hose; s3, measuring the activity of the source liquid bottle by using an activity meter qualified in verification; s4, opening the peristaltic pump to subpackage 0.5ml of medicine into the collection bottle, and then measuring the radioactivity in the collection bottle, and calculating the radioactivity ratio in the source liquid bottle according to the measured radioactivity ratio; s5: when the radiopharmaceutical with the appointed activity is to be obtained, the peristaltic pump is driven to subpackage the radiopharmaceutical with the corresponding volume into the collecting bottle according to the specific activity of the radioactivity, and the subpackaging is finished. The invention has the characteristic of accurate radioactive drug subpackaging.
Description
Technical Field
The invention relates to radiopharmaceutical subpackage, in particular to an automatic radiopharmaceutical subpackage instrument and a subpackage method thereof.
Background
The radioactive drug is subpackaged into each collecting bottle according to the required activity.
In the prior art, after a worker takes a source liquid bottle, the volume and the activity of the source liquid bottle are marked on the source liquid bottle. During the partial shipment, the staff calculates the volume that will divide into the receiving flask according to the ratio of activity and volume, for short specific activity, then uses the syringe to absorb the medicine of certain volume from the source liquid bottle to the receiving flask in, and the radiopharmaceutical of ration activity promptly accomplishes the partial shipment.
On one hand, the radioactive decay of the radioactive drug exists, the activity of the radioactive drug in the source liquid bottle is lower than that of a factory label during subpackaging, and the specific activity obtained through calculation is not accurate; on the other hand, the syringe is seriously affected by human factors, so that the sucked amount is inaccurate, and the split charging precision of the radioactive drug is low due to errors in two aspects.
Disclosure of Invention
The invention aims to provide an automatic radioactive drug subpackaging instrument which has the characteristic of accurate radioactive drug subpackaging.
The above object of the present invention is achieved by the following technical solutions: an automatic split charging instrument for radioactive drugs comprises a peristaltic hose, an output needle and an input needle which are communicated with two ends of the peristaltic hose, a peristaltic pump for extruding the peristaltic hose and a box body for packaging the peristaltic pump.
By adopting the technical scheme, when the radioactive medicine with the appointed activity is required to be subpackaged, the steps are as follows, S1, inserting the output needle head into the source liquid bottle, starting the needle head pushing piece and inserting the input needle head into the current collecting bottle, S2, starting the peristaltic pump to enable the peristaltic hose to be filled with the medicine, wherein the number of running turns of the peristaltic pump can be converted into the volume inside the peristaltic hose; s3, measuring the activity of the source liquid bottle by using an activity meter qualified in verification; s4, opening the peristaltic pump to enable the peristaltic pump to subpackage 0.5ml of medicine into the collection bottle, then measuring the radioactivity in the collection bottle, calculating the radioactivity ratio in the collection bottle, and similarly obtaining the radioactivity ratio and the volume of the source liquid bottle according to the radioactivity ratio of the collection bottle; s5: when the radiopharmaceutical with the specified activity is to be obtained, the peristaltic pump is driven to subpackage the corresponding volume of the radiopharmaceutical into the collection bottle according to the specific activity of the radioactivity, and the radiopharmaceutical with the required activity is obtained.
Compared with the prior art, the amount of the pumped medicine is controlled by the peristaltic pump in the whole process, and the control is more accurate; meanwhile, the activity and specific activity of the medicine in the source liquid bottle can be accurately obtained when the medicine is subpackaged every time, and then the medicine is subpackaged according to the activity and specific activity, so that the influence of radioactive decay is reduced in the process. The two improvements provide the present invention with greater accuracy than the dispensing of the prior art.
The invention is further configured to: the automatic radioactive drug subpackaging instrument further comprises a needle head pushing piece used for vertically pushing the needle head downwards.
By adopting the technical scheme, in actual production, the collection bottle is inserted and pulled out once when the collection bottle is replaced, on one hand, manual operation is labor-consuming, and the efficiency is low; on the other hand, the occurrence probability of radioactive contamination is also increased.
The invention is further configured to: the needle head pushing piece is an electric push rod.
By adopting the technical scheme, the electric push rod is more convenient to use; meanwhile, the electric push rod is simple to obtain a power supply and convenient to assemble.
The invention is further configured to: the needle head pushing part is an air cylinder.
Through adopting above-mentioned technical scheme, the cylinder is comparatively convenient to use.
The invention is further configured to: the needle head pushing part is a hydraulic cylinder.
Through adopting above-mentioned technical scheme, the pneumatic cylinder is comparatively convenient to use.
Another object of the present invention is to provide a dispensing method, which facilitates the automatic dispensing of radiopharmaceuticals using an automatic dispensing apparatus.
The above object of the present invention is achieved by the following technical solutions: a method of dispensing, the method comprising the steps of:
S1: inserting the output needle into the source liquid bottle, starting the needle pushing piece to insert the input needle into the current collection bottle;
s2: starting the peristaltic pump to fill the peristaltic hose with the medicine, wherein the number of running turns of the peristaltic pump can be converted into the volume inside the peristaltic hose;
s3: measuring the activity of the source liquid bottle by using an activity meter qualified in verification;
s4: starting the peristaltic pump to subpackage 0.5ml of medicine into the collecting bottle, then measuring the radioactivity in the collecting bottle, calculating the radioactivity ratio in the collecting bottle, and similarly obtaining the radioactivity ratio and the volume of the source liquid bottle according to the radioactivity ratio of the collecting bottle;
s5: when the radiopharmaceutical with the specified activity is to be obtained, the peristaltic pump is driven to subpackage the corresponding volume of the radiopharmaceutical into the collection bottle according to the specific activity of the radioactivity, and the radiopharmaceutical with the required activity is obtained.
Through adopting above-mentioned technical scheme, the automatic partial shipment appearance of use radiopharmaceutical that can be convenient carries out the partial shipment to the medicine.
In conclusion, the invention has the following beneficial effects: compared with the prior art, the amount of the pumped medicine is controlled by the peristaltic pump in the whole process, and the control is more accurate; meanwhile, the activity and specific activity of the radioactive drug in the source liquid bottle can be accurately obtained during each drug subpackaging, then the subpackaging is carried out according to the activity and specific activity, the influence of radioactive decay is reduced in the process, the improvement of the two aspects enables the subpackaging to have higher accuracy compared with the subpackaging in the prior art, the radioactive drug can cause certain harm to the environment and human bodies, the automatic subpackaging instrument can reduce the time for workers to contact the radioactive drug in a short distance, the box body can isolate certain radioactive pollution, and finally the automatic subpackaging instrument is beneficial to the human bodies and the environment.
Drawings
Figure 1 is a schematic view of an automatic radiopharmaceutical dispensing apparatus with source fluid vials and collection vials.
In the figure, 10, peristaltic hoses; 11. an output needle head; 12. inputting a needle head; 13. a peristaltic pump; 14. a box body; 2. a source liquid bottle; 20. a lead protection can; 3. a collection bottle; 4. a needle pusher.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
Example 1: referring to fig. 1, an automatic radioactive drug dispensing apparatus includes a peristaltic hose 10, an output needle 11 and an input needle 12 connected to two ends of the peristaltic hose 10, a peristaltic pump 13 for squeezing the peristaltic hose 10, and a box 14 for enclosing the peristaltic pump 13.
The output needle 11, with one end of the peristaltic hose 10, extends out of the housing 14 and is inserted into a source bottle 2 placed beside. The source liquid bottle 2 is used for storing medicines before subpackaging in a centralized manner, and a lead protection tank 20 with an opening at the top is sleeved outside the source liquid bottle 2 and used for reducing the radiation level of the surrounding environment of the source liquid bottle 2.
The input needle 12 with the other end of the peristaltic hose 10 is located within the housing 14 and the needle is inserted into a collection vial 3 placed within the housing 14. The collection vial 3 is used to store a radiopharmaceutical of a given activity.
In order to facilitate a reliable and stable insertion of the input needle 12 into each collection vial 3, a needle pusher 4 is also secured in the housing 14. The output end of the needle pusher 4 is connected to the inlet needle 12 and is capable of pushing the inlet needle 12 vertically downwards into the collection vial 3. The needle pusher 4 may be an electric push rod, a small air cylinder or a hydraulic cylinder.
The sub-packaging method corresponding to the automatic sub-packaging instrument for the radioactive drugs comprises the following steps,
s1: inserting the output needle 11 into the source liquid bottle 2, starting the needle pushing piece 14 to insert the input needle 12 into the current collection bottle 3;
s2: starting the peristaltic pump 13 to fill the peristaltic hose 10 with the medicine, wherein the running turns of the peristaltic pump 13 can be converted into the volume inside the peristaltic hose 10;
s3: measuring the activity of the source liquid bottle 2 by using an activity meter qualified in verification;
s4: starting the peristaltic pump 13 to subpackage 0.5ml of the medicine into the collecting bottle 3, then measuring the radioactivity in the collecting bottle 3, calculating the radioactivity ratio in the collecting bottle 3 according to the radioactivity ratio, and similarly obtaining the radioactivity ratio and the volume of the source liquid bottle 2 according to the radioactivity ratio of the collecting bottle 3;
s5: when the radiopharmaceutical with the specified activity is to be obtained, the peristaltic pump 13 is driven to dispense the corresponding volume of the radiopharmaceutical into the collection bottle 3 according to the specific activity of the radioactivity, and the radiopharmaceutical with the required activity is obtained.
The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.
Claims (1)
1. The subpackaging method of the subpackaging instrument is characterized by comprising a peristaltic hose (10), an output needle (11) and an input needle (12) which are communicated with two ends of the peristaltic hose (10), a peristaltic pump (13) for extruding the peristaltic hose (10) and a box body (14) for packaging the peristaltic pump (13), and comprises the following steps:
s1: inserting the output needle (11) into the source liquid bottle (2), and inserting the input needle (12) into the current collection bottle (3);
s2: starting the peristaltic pump (13) to fill the peristaltic hose (10) with the medicine, wherein the number of running turns of the peristaltic pump (13) can be converted into the volume inside the peristaltic hose (10);
s3: measuring the activity of the source liquid bottle (2) by using an activity meter qualified in verification;
s4: starting the peristaltic pump (13) to subpackage 0.5ml of medicine into the collecting bottle (3), then measuring the radioactivity in the collecting bottle (3), calculating the radioactivity ratio activity in the collecting bottle (3), and similarly, obtaining the radioactivity ratio activity and the volume of the source liquid bottle (2) according to the radioactivity ratio activity of the collecting bottle (3);
S5: when the radioactive medicine with the appointed activity is required to be obtained, the peristaltic pump (13) is driven to dispense the corresponding volume of the radioactive medicine into the collecting bottle (3) according to the specific activity of the radioactivity, and the radioactive medicine with the required activity is obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810925293.2A CN110812222B (en) | 2018-08-14 | 2018-08-14 | Automatic radioactive drug subpackaging instrument and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810925293.2A CN110812222B (en) | 2018-08-14 | 2018-08-14 | Automatic radioactive drug subpackaging instrument and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110812222A CN110812222A (en) | 2020-02-21 |
| CN110812222B true CN110812222B (en) | 2022-06-10 |
Family
ID=69547300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810925293.2A Active CN110812222B (en) | 2018-08-14 | 2018-08-14 | Automatic radioactive drug subpackaging instrument and method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110812222B (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102886100A (en) * | 2004-07-16 | 2013-01-23 | 苏黎世大学 | Method and device for accurate dispensing of radioactivity |
| CN102923627A (en) * | 2011-08-10 | 2013-02-13 | 上海原子科兴药业有限公司 | Automatic loading method of radioactive medicines |
| CN203303425U (en) * | 2013-06-26 | 2013-11-27 | 于英 | Multifunctional sampling device |
| CN203598225U (en) * | 2013-12-05 | 2014-05-21 | 兰州汶河医疗器械研制开发有限公司 | Liquid injection medicine dispensing device driven by peristaltic pump |
| CN104958831A (en) * | 2015-07-15 | 2015-10-07 | 成都迈景医药科技有限公司 | Automatic PET-CT radioactive medicine infusing device |
| CN206934337U (en) * | 2017-02-15 | 2018-01-30 | 山西医科大学第一医院 | Iodine 131 automatic ration dispenses instrument |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201102889Y (en) * | 2007-08-16 | 2008-08-20 | 山东省立医院 | Automatic dilution split charging instrument of radionuclide liquid medicine |
| RU2574986C9 (en) * | 2010-06-04 | 2016-11-10 | Байер Медикэл Кер Инк., | Active delivery progression monitoring device |
| WO2013012822A1 (en) * | 2011-07-15 | 2013-01-24 | Cardinal Health 414, Llc | Systems, methods, and devices for producing, manufacturing, and control of radiopharmaceuticals |
-
2018
- 2018-08-14 CN CN201810925293.2A patent/CN110812222B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102886100A (en) * | 2004-07-16 | 2013-01-23 | 苏黎世大学 | Method and device for accurate dispensing of radioactivity |
| CN102923627A (en) * | 2011-08-10 | 2013-02-13 | 上海原子科兴药业有限公司 | Automatic loading method of radioactive medicines |
| CN203303425U (en) * | 2013-06-26 | 2013-11-27 | 于英 | Multifunctional sampling device |
| CN203598225U (en) * | 2013-12-05 | 2014-05-21 | 兰州汶河医疗器械研制开发有限公司 | Liquid injection medicine dispensing device driven by peristaltic pump |
| CN104958831A (en) * | 2015-07-15 | 2015-10-07 | 成都迈景医药科技有限公司 | Automatic PET-CT radioactive medicine infusing device |
| CN206934337U (en) * | 2017-02-15 | 2018-01-30 | 山西医科大学第一医院 | Iodine 131 automatic ration dispenses instrument |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110812222A (en) | 2020-02-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100473598C (en) | Radionuclide liquor automatic separate-charging apparatus and method thereof | |
| US20080237502A1 (en) | System and Method of Identifying Eluant Amounts Supplied to a Radioisotope Generator | |
| CN101839702A (en) | Syringe size marking system and method for syringe pumps | |
| EP3549143B1 (en) | Systems and methods for dispensing radioactive liquids | |
| CN103592670A (en) | Gamma radioactive gas body source absolute detection efficiency calibration device and method | |
| CN103920211A (en) | High-precision micro-injection pump and application thereof | |
| CN110812222B (en) | Automatic radioactive drug subpackaging instrument and method | |
| JP5118236B2 (en) | A method of injecting a sample to be analyzed into a measuring cell, particularly an injection tube of a density meter | |
| CN203989281U (en) | A kind of high-precision micro-injection pump | |
| CN103424762B (en) | Standard source for radioactive waste barrel segmenting gamma scanning device scales | |
| CN202329726U (en) | Intelligent high-precision seal anti-explosion oil tank volume measurement and calibration system | |
| CN205719158U (en) | A kind of liquid-volume measurement apparatus | |
| CN2905751Y (en) | Automatic split-packing instrument for radioactive nuclide liquor | |
| CN207445295U (en) | A kind of radiopharmaceutical automatic subpackaging injection instrument | |
| CN201382779Y (en) | Syringe-size marking system for micro-syringe pump | |
| CN202957050U (en) | Radioactive medicine protective pot and integral radioactive medicine collecting and packaging device | |
| CN202154861U (en) | Pre-embedment injector with scales | |
| CN102923627B (en) | Automatic loading method of radioactive medicines | |
| WO2014196937A1 (en) | A fully automatic drug preparation device with a synchronized triple verification system (stvs) | |
| CN203425313U (en) | Calibration device of injector | |
| CN213850648U (en) | Water cup for measuring pancreas islet function of patient | |
| CN117724145B (en) | Method and device for acquiring activity of planar applicator, electronic equipment and storage medium | |
| CN211877156U (en) | Measuring device for medicament analysis | |
| CN109012322A (en) | A kind of animal husbandry thimerosal device for formulating | |
| CN214096156U (en) | Device for measuring volume and specific activity of radioactive liquid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |