CN110779836A - Atomized particle size testing equipment and method - Google Patents
Atomized particle size testing equipment and method Download PDFInfo
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- CN110779836A CN110779836A CN201911214479.8A CN201911214479A CN110779836A CN 110779836 A CN110779836 A CN 110779836A CN 201911214479 A CN201911214479 A CN 201911214479A CN 110779836 A CN110779836 A CN 110779836A
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- 239000002245 particle Substances 0.000 title claims abstract description 186
- 238000012360 testing method Methods 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title description 15
- 238000012545 processing Methods 0.000 claims abstract description 27
- 230000003287 optical effect Effects 0.000 claims abstract description 12
- 230000001678 irradiating effect Effects 0.000 claims abstract description 4
- 238000010998 test method Methods 0.000 claims abstract description 3
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 abstract description 8
- 238000005259 measurement Methods 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000000443 aerosol Substances 0.000 description 13
- 239000007921 spray Substances 0.000 description 7
- 239000006199 nebulizer Substances 0.000 description 5
- 239000008187 granular material Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 210000003123 bronchiole Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002664 inhalation therapy Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 238000002663 nebulization Methods 0.000 description 1
- 238000011369 optimal treatment Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 210000003456 pulmonary alveoli Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000009121 systemic therapy Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0205—Investigating particle size or size distribution by optical means
- G01N15/0211—Investigating a scatter or diffraction pattern
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- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The application discloses atomized particle size testing equipment, which comprises a sample cell, a particle size analyzer and a particle size analyzer, wherein the sample cell is used for containing atomized particles; the laser is positioned on one side of the sample cell and is used for emitting light rays for irradiating the sample cell; the collimation beam expanding lens is positioned between the laser and the sample cell; the Fourier transform lens is arranged opposite to the collimation beam expanding lens and used for focusing light passing through the sample cell, and the focal length of the Fourier transform lens is below 50 mm; the detector is matched with the Fourier transform lens and is used for collecting the optical signal of the focused light; and the particle size distribution data processing device is connected with the detector and used for obtaining the particle size distribution of the atomized particles according to the optical signal and sending the particle size distribution to the control system of the atomizer connected with the particle size distribution data processing device so that the atomizer can adjust the driving force. The device has the advantages of miniaturization and on-line measurement, and can make atomized medicines with different particle sizes reach the needed affected part, thereby improving the utilization rate of the medicines. The application also provides a test method with the above points.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to atomized particle size testing equipment and method.
Background
The aerosol inhalation therapy mainly aims at cleaning air passages, local therapy and systemic therapy. Research shows that aerosol particles with the particle size of 5-20 mu m are mainly deposited to oral cavity, nose and upper respiratory tract, aerosol particles with the particle size of 2-5 mu m are mainly deposited to small bronchus and bronchiole, and aerosol particles with the particle size of less than 2 mu m are mainly deposited to alveolus. The aerosol particles are detected, and different aerosol particle sizes are selected according to the disease requirements, so that the optimal treatment effect can be achieved.
At present, it is mature to adopt a spray laser particle size analyzer to detect aerosol particles generated by an atomizing device, the atomizing device sprays the aerosol particles into the air, and the spray laser particle size analyzer detects the aerosol particles, so as to obtain the particle size of the aerosol particles. However, the existing spray laser particle size analyzer has a large volume and a large weight, can only be generally carried out in a laboratory, and has a limited application range, and when the particle size of aerosol particles needs to be adjusted to meet a preset requirement, the existing spray laser particle size analyzer cannot be linked with a spraying device to realize online measurement.
Therefore, how to provide a testing device which is miniaturized and light-weighted and can measure the particle size of aerosol particles on line is a technical problem to be solved urgently by those skilled in the art.
Disclosure of Invention
The application aims to provide atomized particle size testing equipment and an atomized particle size distribution testing method so as to achieve miniaturization, light weight and online testing of atomized particle size distribution testing equipment.
In order to solve the above technical problem, the present application provides an atomized particle size testing apparatus, including:
a sample cell for containing the atomized particles;
the laser is positioned on one side of the sample cell and is used for emitting light rays for irradiating the sample cell;
a collimating beam expander lens positioned between the laser and the sample cell;
the Fourier transform lens is arranged opposite to the collimation beam expanding lens and used for focusing light passing through the sample cell, and the focal length of the Fourier transform lens is below 50 mm;
the detector is matched with the Fourier transform lens and is used for collecting the optical signal of the focused light;
and the particle size distribution data processing device is connected with the detector and used for obtaining the particle size distribution of the atomized particles according to the optical signal and sending the particle size distribution to the atomizer connected with the particle size distribution data processing device so that the atomizer can adjust and generate the driving force of the atomized particles.
Optionally, the detector includes:
a stacked annular array detector and a central single point detector, wherein the annular array detector is proximate to the Fourier transform lens.
Optionally, the granularity distribution data processing device includes one of an upper computer and a lower computer, an analog-to-digital converter, and a signal amplifier.
Optionally, the method further includes:
the atomizer is respectively connected with the particle size distribution data processing device and the sample pool.
Optionally, the method further includes:
and the prompting device is used for sending out prompting information when the particle size distribution meets the preset condition.
Optionally, the atomizer is an ultrasonic atomizer or a mesh atomizer.
The application also provides an atomized particle size testing method, which comprises the following steps:
acquiring an electrical signal, wherein the electrical signal is derived from light conversion by a sample cell containing the atomized particles;
determining the particle size distribution of the atomized particles according to the electrical signal;
sending the particle size distribution to a control system of an atomizer such that the atomizer adjusts a driving force that generates the atomized particles.
Optionally, the method further includes:
and sending out prompt information when the particle size distribution meets the preset condition.
The atomized particle size testing equipment provided by the application comprises a sample cell, a particle size analyzer and a particle size analyzer, wherein the sample cell is used for containing atomized particles; a laser positioned on one side of the sample cell for emitting light that illuminates the sample cell; a collimating beam expander lens positioned between the laser and the sample cell; the Fourier transform lens is arranged opposite to the collimation beam expanding lens and used for focusing light passing through the sample cell, and the focal length of the Fourier transform lens is below 50 mm; the detector is matched with the Fourier transform lens and is used for collecting optical signals of the focused light; and the particle size distribution data processing device is connected with the detector and used for obtaining the particle size distribution of the atomized particles according to the optical signal and sending the particle size distribution to a control system of an atomizer connected with the particle size distribution data processing device so that the atomizer can adjust and generate the driving force of the atomized particles.
It can be seen that the atomized particle size testing device in the application comprises a sample cell, a laser, a collimation beam expanding lens, a Fourier transform lens, a detector and a particle size distribution data processing device, wherein the focal length of the Fourier transform lens is below 50mm, the volume of the Fourier transform lens is small, correspondingly, the volume of the detector matched with the Fourier transform lens is also small, so that the atomized particle size distribution testing device is small in volume and light in weight, and the particle size distribution data processing device is directly connected with an atomizer, after the particle size distribution data processing device determines the particle size distribution of atomized particles, the particle size distribution can be sent to a control system of the atomizer, the atomizer adjusts the driving force for driving the atomized particles, thereby changing the particle size distribution of the atomized particles to enable the atomized particles to meet the preset requirements, realizing the on-line measurement of the atomized particles, and further realizing that atomized medicines with different particle sizes accurately reach different patient positions to be treated, the utilization rate of the atomized medicine and the atomization treatment efficiency are improved. In addition, the application also provides an atomized particle size testing method with the advantages.
Drawings
For a clearer explanation of the embodiments or technical solutions of the prior art of the present application, the drawings needed for the description of the embodiments or prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
Fig. 1 is a schematic structural diagram of an atomized particle size testing apparatus provided in an embodiment of the present application;
fig. 2 is a flowchart of an atomized particle size testing method provided in an embodiment of the present application.
Detailed Description
In order that those skilled in the art will better understand the disclosure, the following detailed description will be given with reference to the accompanying drawings. It is to be understood that the embodiments described are only a few embodiments of the present application and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be practiced in other ways than those specifically described and will be readily apparent to those of ordinary skill in the art without departing from the spirit of the present invention, and therefore the present invention is not limited to the specific embodiments disclosed below.
As described in the background section, the existing spray laser particle size analyzer is large in size and weight, and can only be performed in a laboratory, and when the particle size of aerosol particles needs to be adjusted to meet a predetermined requirement, the existing spray laser particle size analyzer cannot be linked with a spraying device to realize online measurement.
In view of the above, the present application provides an atomized particle size testing apparatus, please refer to fig. 1, where fig. 1 is a schematic structural diagram of an atomized particle size testing apparatus provided in an embodiment of the present application, and the apparatus includes:
a sample cell 1 for containing atomized particles;
the laser 2 is positioned on one side of the sample cell 1 and is used for emitting light rays irradiating the sample cell 1;
a collimating beam expanding lens 3 positioned between the laser 2 and the sample cell 1;
the Fourier transform lens 4 is arranged opposite to the collimation beam expanding lens 3 and used for focusing light passing through the sample cell 1, and the focal length of the Fourier transform lens 4 is less than 50 mm;
the detector 5 is matched with the Fourier transform lens 4 and is used for collecting optical signals of the focused light rays;
and the particle size distribution data processing device 6 is connected with the detector 5 and is used for obtaining the particle size distribution of the atomized particles according to the optical signal and sending the particle size distribution to a control system of the atomizer 7 connected with the particle size distribution data processing device 6 so that the atomizer 7 can adjust and generate the driving force of the atomized particles.
Wherein, the sample cell 1 is provided with an outlet and an inlet of the atomized particles, the inlet is connected with the atomizer 7 through the interface 8, and the outlet is connected with a pipeline for the patient to inhale the atomized particles through the interface 8.
Specifically, in an embodiment of the present application, the detector 5 includes:
a stacked annular array detector 51 and a central single point detector 52, wherein the annular array detector 51 is close to the fourier transform lens 4. The annular array detector 51 is composed of a series of concentric photosensitive rings and non-photosensitive insulated channels, and according to Mie scattering theory, the closer to the center of the ring, the smaller the scattering angle of the particles, the larger the particle size, and vice versa. The central single-point detector 52 is a high-sensitivity low-dark-current single-sensitive-surface silicon photodiode detector 5, and responds to visible light and near infrared light with wave bands of 350nm to 1000 nm.
Specifically, the collimating beam expander lens 3 based on galileo can perform spot expansion and divergence angle reduction on the narrow-band laser beam output by the laser 2 to obtain a large spot parallel light beam, irradiate more atomized particles, the large spot parallel light beam is scattered by the atomized particles, the scattered light is focused on the annular array detector 51 at the focal plane position by the fourier transform lens 4, the non-scattered light is focused on the central single-point detector 52 at the focal plane position by the fourier transform lens 4, the optical signal acquired by the detector 5 is transmitted to the particle size distribution data processing device 6, the particle size distribution data processing device 6 then transmits the particle size distribution to the control system of the atomizer 7, when the particle size is larger than the required particle size, the controller of the atomizer 7 controls the driving force to be increased, so that the particle size of the atomized particles is decreased, when the particle size is smaller than the required particle size, the controller of the atomizer 7 controls the driving force to be decreased, thereby make the particle diameter grow of atomizing granule, realize the on-line measuring of granularity promptly, and then realize that the atomizing medicine of different particle diameters is accurate to reach the different disease positions that need the treatment, improves atomizing medicine utilization ratio.
In an embodiment of the present application, the particle size distribution data processing device 6 includes one of an upper computer 63 and a lower computer 63, an analog-to-digital converter 61, and a signal amplifier 62, where the analog-to-digital converter 61 is configured to convert an optical signal into an electrical signal, the signal amplifier 62 is configured to amplify a signal-to-noise ratio of the electrical signal, and the upper computer 63 or the lower computer 63 performs inverse calculation of particle size distribution of the atomized particles according to the electrical signal to determine the particle size distribution of the atomized particles, and a specific determination process of the particle size distribution is well known to those skilled in the art and will not be described in detail herein.
The atomized particle granularity testing equipment comprises a sample cell 1, a laser 2, a collimation beam expanding lens 3, a Fourier transform lens 4, a detector 5 and a granularity distribution data processing device 6, wherein the focal length of the Fourier transform lens 4 is less than 50mm, the size is small, and correspondingly, the detector 5 matched with the Fourier transform lens 4 has small volume, so that the atomized particle size distribution testing equipment has small volume and light weight, and the particle size distribution data processing means 6 is directly connected to the atomizer 7, and when the particle size distribution data processing means 6 determines the particle size distribution of the atomized particles, the particle size distribution can be sent to the control system of the atomizer 7, causing the atomizer 7 to adjust the driving force that drives the atomized particles, therefore, the particle size distribution of the atomized particles is changed to enable the atomized particles to meet the preset requirements, and the online measurement of the atomized particles is realized.
Optionally, on the basis of the above embodiment, in an embodiment of the present application, the atomized particle size distribution test apparatus further includes:
and the atomizer 7 is respectively connected with the particle size distribution data processing device 6 and the sample pool 1.
Specifically, the atomizer 7 is connected to the upper computer 63 or the lower computer 63 of the particle size distribution data processing device 6, and it should be noted that, in this embodiment, the connection relationship between the atomizer 7 and the particle size distribution data processing device 6 is not specifically limited, as the case may be. For example, the atomizer 7 and the particle size distribution data processing device 6 are connected in a wired manner, or in a wireless manner, and further, the wireless connection manner may be bluetooth, wifi, or the like.
It is to be noted that the kind of the atomizer 7 is not particularly limited in the present embodiment, as the case may be. The nebulizer 7 is, for example, an ultrasonic nebulizer 7 or a mesh nebulizer 7, or a ventilator for maintaining vital signs of a patient in a hospital intensive care unit, but may also be a portable nebulizer 7 for clinical nebulization treatment of respiratory diseases or for home use, a small dose nebulizer 7, or the like. Among them, the small-dose atomizer 7 is low in price and most widely used in clinic; the mesh atomiser 7 is optimised but expensive.
Optionally, on the basis of any one of the above embodiments, in an embodiment of the present application, the atomized particle size distribution test apparatus further includes:
and the prompting device is used for sending out prompting information when the particle size distribution meets the preset condition.
It should be noted that, in this embodiment, the preset condition is not specifically limited, and may be set by itself. For example, the preset condition may be D
5010 μm, or D
972 μm, etc.
Referring to fig. 2, fig. 2 is a flowchart of an atomized particle size testing method according to an embodiment of the present disclosure, where the method includes:
step S101: acquiring an electrical signal, wherein the electrical signal is derived from light conversion by passing through a sample cell containing the atomized particles.
Step S102: and determining the particle size distribution of the atomized particles according to the electric signal.
Specifically, the specific process of completing the inverse calculation of the particle size distribution of the atomized particles according to the electrical signal to determine the particle size distribution of the atomized particles is well known to those skilled in the art, and will not be described in detail herein.
Step S103: sending the particle size distribution to a control system of an atomizer such that the atomizer adjusts a driving force that generates the atomized particles.
The method for testing the particle size of the atomized particles provided by the embodiment is applied to the device for testing the particle size of the atomized particles described in the embodiment, and the method comprises the steps of obtaining an electrical signal, wherein the electrical signal is obtained by light conversion of a sample cell containing the atomized particles; determining the particle size distribution of the atomized particles according to the electrical signal; send the control system of size distribution to atomizer, so that the atomizer adjustment drive the drive power of atomizing granule, when the particle diameter is greater than required particle diameter, the controller control drive power grow of atomizer, thereby make the particle diameter of atomizing granule diminish, when the particle diameter is less than required particle diameter, the controller control drive power of atomizer diminishes, thereby make the particle diameter grow of atomizing granule, realize the on-line measuring of granularity, and then realize that the atomized medicine of different particle diameters accurately reachs the different disease positions that need the treatment, improve atomized medicine utilization ratio.
Preferably, the atomized particle size test method further comprises:
and sending out prompt information when the particle size distribution meets the preset condition.
It should be noted that, in this embodiment, the prompt information is not specifically limited, as the case may be. For example, the prompt may be an audible prompt and/or a textual prompt.
The embodiments are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same or similar parts among the embodiments are referred to each other. The device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.
The atomized particle size testing device and method provided by the present application are described in detail above. The principles and embodiments of the present application are explained herein using specific examples, which are provided only to help understand the method and the core idea of the present application. It should be noted that, for those skilled in the art, it is possible to make several improvements and modifications to the present application without departing from the principle of the present application, and such improvements and modifications also fall within the scope of the claims of the present application.
Claims (8)
1. An atomized particle size testing apparatus, comprising:
a sample cell for containing the atomized particles;
the laser is positioned on one side of the sample cell and is used for emitting light rays for irradiating the sample cell;
a collimating beam expander lens positioned between the laser and the sample cell;
the Fourier transform lens is arranged opposite to the collimation beam expanding lens and used for focusing light passing through the sample cell, and the focal length of the Fourier transform lens is below 50 mm;
the detector is matched with the Fourier transform lens and is used for collecting optical signals of the focused light;
and the particle size distribution data processing device is connected with the detector and used for obtaining the particle size distribution of the atomized particles according to the optical signal and sending the particle size distribution to a control system of an atomizer connected with the particle size distribution data processing device so that the atomizer can adjust and generate the driving force of the atomized particles.
2. The atomized particle size testing apparatus of claim 1, wherein the detector comprises:
a stacked annular array detector and a central single point detector, wherein the annular array detector is proximate to the Fourier transform lens.
3. The atomized particle size testing apparatus of claim 2, wherein the size distribution data processing device includes one of an upper computer and a lower computer, an analog-to-digital converter, and a signal amplifier.
4. The atomized particle size testing apparatus of claim 3, further comprising:
the atomizer is respectively connected with the particle size distribution data processing device and the sample pool.
5. The atomized particle size testing apparatus of claim 4, further comprising:
and the prompting device is used for sending out prompting information when the particle size distribution meets the preset condition.
6. The atomized particle size testing apparatus of claim 5, wherein the atomizer is an ultrasonic atomizer or a mesh atomizer.
7. An atomized particle size testing method is characterized by comprising the following steps:
acquiring an electrical signal, wherein the electrical signal is derived from light conversion by a sample cell containing the atomized particles;
determining the particle size distribution of the atomized particles according to the electrical signal;
sending the particle size distribution to a control system of an atomizer such that the atomizer adjusts a driving force that generates the atomized particles.
8. The atomized particle size test method of claim 6, further comprising:
and sending out prompt information when the particle size distribution meets the preset condition.
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| CN111634915A (en) * | 2020-06-12 | 2020-09-08 | 将乐三晶新材料有限公司 | Atomization powder making process for molten metal silicon |
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| CN112057709A (en) * | 2020-09-21 | 2020-12-11 | 中国科学院长春光学精密机械与物理研究所 | External air source driving atomization device |
| CN112557270A (en) * | 2020-12-11 | 2021-03-26 | 中国烟草总公司郑州烟草研究院 | Device for synchronously detecting smoke discharge amount of multiple cigarettes |
| CN113188961A (en) * | 2021-03-30 | 2021-07-30 | 湘潭市计量测试检定所 | Detection method for equivalent volume particle size distribution of medical compressed atomizer fog particles |
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Application publication date: 20200211 |