CN110742583A - Spectral shaping method for polarization-sensitive optical coherence tomography demodulation of catheter - Google Patents
Spectral shaping method for polarization-sensitive optical coherence tomography demodulation of catheter Download PDFInfo
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- CN110742583A CN110742583A CN201910954729.5A CN201910954729A CN110742583A CN 110742583 A CN110742583 A CN 110742583A CN 201910954729 A CN201910954729 A CN 201910954729A CN 110742583 A CN110742583 A CN 110742583A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
Abstract
A spectral shaping method for the polarization-sensitive optical coherence tomography demodulation of a catheter is characterized in that time-frequency localization is realized in a signal windowing mode, the signal windowing can correct the problem of spectral leakage, and different window functions are selected to influence the resolution and the signal-to-noise ratio. The invention lays a foundation for obtaining the vascular birefringence information.
Description
Technical Field
The invention relates to the field of catheter imaging covering cardiovascular and cerebrovascular systems and the like by catheter Optical Coherence Tomography (OCT), in particular to birefringent information of a demodulation sample in a catheter Polarization-sensitive OCT (Polarization-sensitive OCT) image, namely a PS-OCT image, and particularly relates to a spectral shaping method for demodulating the catheter Polarization-sensitive OCT.
Background
The catheter OCT imaging technology is a blood vessel imaging method with the highest image resolution at present, particularly the catheter PS-OCT imaging technology, can solve the medical problem that the stability of atherosclerotic plaques is difficult to judge in vivo, in real time and rapidly, and can improve the prevention and treatment effect of atherosclerotic diseases. However, the existing OCT system has reached a level that may determine the property of the tissue plaque in terms of resolution, but is still insufficient in terms of tissue penetration ability, image sharpness, and accuracy of tissue plaque type determination, and using the PS-OCT technology, improving the performance of the related technology is a key direction for development of the OCT system, and is also a necessary way to solve the aforementioned key scientific problems.
In catheter OCT, catheter PS-OCT is an extension of catheter OCT technology, which provides a quantitative measure of tissue birefringence properties. The birefringence of light changes the polarization state of light and can be associated with proteins and biological macromolecules with oriented structures such as collagen, actin, and the like. The enhanced birefringence phenomenon of catheter PS-OCT is closely related to the existence of a large amount of thick collagen fibers or intimal smooth muscle cells, so that the high-resolution detection of catheter PS-OCT imaging can be applied to the enhanced plaque stability measurement. In addition, catheter PS-OCT systems have the potential to assess plaque collagen and differentiate normal intima, fibrous plaque, lipid plaque, and calcified plaque, among others.
A corresponding catheter polarization-sensitive optical coherence tomography system and a demodulation method are designed for this purpose, wherein a fast scanning light source is adopted as a light source in the system, a polarization-maintaining optical fiber is adopted in the system to generate orthogonal polarization state delay, polarization diversity acquisition is carried out through a polarization beam splitter, and orthogonal two input polarization state polarization diversity imaging is presented in an image at the same time. The demodulation method finally realizes the vascular birefringence imaging through a series of steps of polarization leveling, background signal elimination, spectrum shaping, two-state dispersion elimination, interpolation Fourier transform, reference surface selection, polarization settlement, polar coordinate conversion to Cartesian coordinates and the like. While spectral shaping directly affects the accuracy and efficiency of demodulation.
Disclosure of Invention
The invention aims to solve the problem that the existing OCT catheter optical coherence tomography system can only acquire blood vessel intensity information, and provides a spectral shaping method for catheter polarization sensitive optical coherence tomography demodulation.
The technical scheme of the invention is as follows:
a spectral shaping method for the polarization-sensitive optical coherence tomography demodulation of a conduit is characterized in that time-frequency localization is realized in a signal windowing mode, the problem of spectral leakage can be corrected by signal windowing, and the resolution and the signal-to-noise ratio are influenced finally by selecting different window functions, so that the optimal spectral shaping scheme is selected by calculating the resolution and the signal-to-noise ratio through selecting different window functions.
The interference signal in the k-domain is windowed by passing it through a Cosine pyramid (Cosine Tapered) window, the windowed signal being represented as:
wherein y represents an output sequence, i.e. a windowed x-sequence, n is the number of elements in the x-sequence, r is the ratio of the total length of the tapered portion to the total length of the signal, and m is rounded downward; when r is less than or equal to 0, the window is equivalent to a Rectangular (Rectangular) window; when r is larger than or equal to 1, the window is equivalent to a Hanning (Hanning) window, and n and r are traversed according to the process by setting the requirement of target resolution.
The invention has the beneficial effects that:
the method is beneficial to improving the demodulation efficiency and accuracy of the polarization-sensitive optical coherence tomography of the catheter, and lays a foundation for the normal demodulation.
Drawings
FIG. 1 is a flow chart of catheter polarization-sensitive optical coherence tomography demodulation in accordance with the present invention.
Fig. 2 is a flow chart of the spectral shaping of the present invention.
FIG. 3 is a schematic view of a cosine tapered window of the present invention.
Detailed Description
The invention is further described below with reference to the figures and examples.
As shown in fig. 1-3.
A demodulation method of catheter polarization-sensitive optical coherence tomography, as shown in fig. 1, comprising the steps of: the method comprises a series of steps of polarization leveling, background signal elimination, spectrum shaping, two-state dispersion elimination, interpolation Fourier transform, reference surface selection, polarization settlement, polar coordinate conversion to Cartesian coordinates and the like, and finally vascular birefringence imaging is achieved. The spectral shaping is to realize time-frequency localization by signal windowing, and on the other hand, the signal windowing can correct the problem of spectral leakage. In OCT systems, choosing different window functions ultimately affects resolution and signal-to-noise ratio. Therefore, the resolution and the signal-to-noise ratio can be calculated by selecting different window functions to select the optimal spectral shaping scheme, as shown in fig. 2.
It has been found experimentally that in a polarization OCT system, better results are obtained by passing the interference signal of k-domain through a cosine tapered (cosine tapered) window, which can be expressed as:
where Y represents the output sequence, i.e., the windowed X sequence, n is the number of elements in the X sequence, r is the ratio of the total length of the cone to the total length of the signal, and m is rounded downward. When r ≦ 0, the window corresponds to a Rectangular (Rectangular) window. When r is equal to or greater than 1, the window is equivalent to a Hanning (Hanning) window, and the cosine cone window is schematically shown in FIG. 3. For different systems, only a reasonable target resolution requirement is set, and n and r are traversed according to the process.
The parts not involved in the present invention are the same as or can be implemented using the prior art.
Claims (2)
1. A spectral shaping method for the polarization-sensitive optical coherence tomography demodulation of a catheter is characterized in that time-frequency localization is realized in a signal windowing mode, the signal windowing can correct the problem of spectral leakage, and different window functions are selected to influence the resolution and the signal-to-noise ratio.
2. The method of claim 1, wherein the interference signal in the k-domain is windowed by passing it through a cosine tapered (cosine) window, the windowed signal being represented by:
wherein y represents an output sequence, i.e. a windowed x-sequence, n is the number of elements in the x-sequence, r is the ratio of the total length of the tapered portion to the total length of the signal, and m is rounded downward; when r is less than or equal to 0, the window is equivalent to a Rectangular (Rectangular) window; when r is larger than or equal to 1, the window is equivalent to a Hanning (Hanning) window, and n and r are traversed according to the process by setting the requirement of target resolution.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113888478A (en) * | 2021-09-15 | 2022-01-04 | 天津大学 | Optimized depolarization method for intravascular catheter polarization-sensitive coherent tomography |
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| CN113888478A (en) * | 2021-09-15 | 2022-01-04 | 天津大学 | Optimized depolarization method for intravascular catheter polarization-sensitive coherent tomography |
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