CN1107341A - Compound garlic oil capsule and its producing method - Google Patents
Compound garlic oil capsule and its producing method Download PDFInfo
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- CN1107341A CN1107341A CN 94108044 CN94108044A CN1107341A CN 1107341 A CN1107341 A CN 1107341A CN 94108044 CN94108044 CN 94108044 CN 94108044 A CN94108044 A CN 94108044A CN 1107341 A CN1107341 A CN 1107341A
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- bulbus allii
- garlic oil
- oleum bulbus
- capsule
- inclusion complex
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Abstract
The compound garlic oil capsule for treating hyperlipemia, atherosclerosis, tumor, diabetes mellitus, hypertension, etc. is prepared through preparing garlic oil from garlic cloves and its inclusion compound, mixing with kelp and coix seed, and capsulizing. It features no odour garlic has uniquely.
Description
The present invention relates to Chinese medicine product, especially for a kind of with Bulbus Allii, Thallus Laminariae (Thallus Eckloniae), Semen Coicis, beta-schardinger dextrin-be raw material, the compound garlic oil capsule and the production method thereof of the medicine-food two-purpose made by certain technology, proportioning.
Bulbus Allii, have another name called calabash, giant garlic, be the bulb of Liliaceae biennial herb plant Bulbus Allii AIiumsativumL..It is seasoning Cui dish commonly used in the people life still, and has medical care effect very widely.In China and all over the world, Bulbus Allii is as the edible and history in existing thousands of years of medication among the people.So far, the document that relevant Bulbus Allii is treated multiple disease is vast as the open sea, and its medical value is also confirmed by clinical and breadboard achievement in research gradually.In recent years, along with the continuous development of science and technology, people are more deep and extensive to the research of Bulbus Allii.Bulbus Allii is causing countries in the world relevant expert's very big concern with its magical medical value and medical widely potentiality.In the U.S., discover that Bulbus Allii can make the sickness rate of breast carcinoma, colon cancer, bladder cancer patients descend; Studies show that in India Bulbus Allii can bring high blood pressure down, reduce cardiopathic outbreak;
China be Bulbus Allii in the world main product one of, domestic a lot of scholar experts have also carried out a large amount of experimentatioies to Bulbus Allii, think that Bulbus Allii and extract thereof have blood fat reducing, antiplatelet aggregation, prevent the atherosclerosis effect; Polytype tumor cell there is tangible deactivation; The function that human body immunity improving power is arranged.These pharmaceutically-active ingredients of Bulbus Allii mainly are the sulfur-containing compounds in the Bulbus Allii etc.These compositions mainly are present in the volatile oil of Bulbus Allii.That is: in the Oleum Bulbus Allii.Have effects such as the formation of anti-inflammation, blood fat reducing, anticoagulant, minimizing coronary artery atheromatous plaque and antitumor as: Oleum Bulbus Allii.
The Oleum Bulbus Allii method for making: after Bulbus Allii is put the interior fragmentation of pulverizer, promptly should drop into and extract in the pot, and add 6 times of water gagings, and carry out vapor distillation, collection volatile oil is told lower floor, promptly gets needed Oleum Bulbus Allii.Oleum Bulbus Allii of the present invention is: Zhongmou County, Zhengzhou bioid factory produces.Its character: yellow to the salmon pink oily liquids, acrid in the mouth is peppery, has the Bulbus Allii stink, relative density D
20 41.040-1.090, index of refraction n
25 251.559-1.579.
Though Oleum Bulbus Allii has medicinal curative effect, weak point is: off-odor is arranged, gastric mucosa is had than strong and stimulating, and volatile under the room temperature, perishable in air.
For keeping the medicinal curative effect of Oleum Bulbus Allii, the system of unit that has makes the Oleum Bulbus Allii soft gelatin capsule, but after this thin soft Oleum Bulbus Allii soft gelatin capsule (content is an oily liquids) is made, deposit in the air in naturalness, people just can smell micro-Oleum Bulbus Allii stink, if after people eat, beat when coughing, the mouth and nose place still has the sense of Oleum Bulbus Allii stink, and the Oleum Bulbus Allii stink has appearred in the office occasion when being on duty, and can increase the sense of discomfort to people.
The objective of the invention is to keeping under the Oleum Bulbus Allii medicinal effects prerequisite, avoid the weak point in the above prior art, and provide a kind of is major ingredient and compound garlic oil capsule and the production method thereof that contains abundant Oleum Bulbus Allii with the Bulbus Allii, the compound garlic oil capsule of being made (content is a powder) product, in air, do not deposit naturally and can give out the Oleum Bulbus Allii stink, and after taking, beat when coughing, the mouth and nose place does not also have the sense of Oleum Bulbus Allii stink.
The object of the present invention is achieved like this:
After Bulbus Allii is made Oleum Bulbus Allii, the Oleum Bulbus Allii that has obtained is made Oleum Bulbus Allii (beta-schardinger dextrin-) inclusion complex earlier, purpose is the medicinal effects that had both kept Oleum Bulbus Allii, and the stink of Oleum Bulbus Allii is not outwards distributed; The Oleum Bulbus Allii inclusion complex that makes and Thallus Laminariae (Thallus Eckloniae), Semen Coicis according to a certain ratio, technology and form a kind of compound preparation, dosage form is a capsule, its compound preparation is inserted in the capsule, this capsule-type compound preparation is called as compound garlic oil capsule.
The pharmacology record of relevant medicinal plants Thallus Laminariae (Thallus Eckloniae), Semen Coicis:
Thallus Laminariae (Thallus Eckloniae): " Bencao Jingshu " speech " Thallus Laminariae (Thallus Eckloniae), salty energy softening the hard mass, its property relaxing the bowels with lubricant drugs, cold energy heat extraction eliminating stagnation, thus main 12 kinds of edema, the coalescent gas fistula of goiter skin ulcer." eastern wall cloud: " wart is hard as the stone person, does not more non-ly remove, and the merit of just salty energy softening the hard mass is also." " explaining abstruseness of the canon of materia medica ": " main dysphagic "." beautiful Chinese catalpa medicine is separated " says it, and " sluicing is dried, the removing mass softening the hard mass." " book on Chinese herbal medicine converges " " property of Thallus Laminariae (Thallus Eckloniae), male in Sargassum, the disease of choking is permanent uses it, and lid is got its old expectorant also [8] of dispelling." in a word, Thallus Laminariae (Thallus Eckloniae) is good at the softening the hard mass removing mass.To dysphagic, goiter, edema etc. have better curative effect.
Semen Coicis:
Compendium of Material Medica says that " stomach reinforcing that is good for the stomach, wind prevailing over dampness is removed in the tonifying the lung heat clearing away for it." " the bright medicine of Semen Coicis sun also can invigorating spleen and reinforcing stomach." " medicine justice ": " and Semen Coicis, sweet in the mouth gas and, clear in turbid product, can spleen invigorating the moon, big beneficial the intestines and stomach." " book on Chinese herbal medicine is stated " " and Semen Coicis, dehumidifying and not as two arts help dry, heat clearing away and not as a kind of reed mentioned in ancient books, connect the generation to decrease the moon, QI invigorating and still grow damp and hotly not as ginseng, art generation really is a gas key medicine in the benefit." [9] above-mentioned ancients' argumentation, point out that all Semen Coicis is major function with the invigorating spleen and reinforcing stomach.
From the document of the modern study of above Bulbus Allii, Thallus Laminariae (Thallus Eckloniae), Semen Coicis, Bulbus Allii, Thallus Laminariae (Thallus Eckloniae) all have tangible blood fat reducing, effect that prevention of arterial is atherosis; Bulbus Allii, Semen Coicis all have the effect of enhancing human body immunity function; Simultaneously, three medicines all have anti-tumor activity, but the three respectively has speciality aspect the antineoplastic kind.Therefore, three medicines share, and can learn from other's strong points to offset one's weaknesses mutually, better play blood fat reducing, prevent and treat atherosclerosis, effect such as antitumor, human body immunity improving power.
The manufacture method of compound garlic oil capsule is referring to technological process of production figure.
The composition of Oleum Bulbus Allii inclusion complex, ratio of component, manufacture method are:
Beta-schardinger dextrin-75-150g
Oleum Bulbus Allii 15ml
Distilled water 300ml
Method for making: get beta cyclodextrin (75-150g), adding 300ml water stirs in colloid mill, then in colloid mill, add the 15ml Oleum Bulbus Allii, colloid mill is fully milled mixed 5 minutes, obtain leaving standstill in pastel, the container, dry, wash with water, 40 ℃ of dryings, white cellular thing, promptly obtain the Oleum Bulbus Allii inclusion complex of white powder after pulverizing.
Used beta-schardinger dextrin-is that capital, Yunan County, Guangdong Province cyclodextrin factory produces, and is commercial raw material.
Used Oleum Bulbus Allii is commercial raw material, produce by Zhongmou County, Zhengzhou bioid factory, this Oleum Bulbus Allii also can oneself be produced, but no matter the relative density of own production or commercial Oleum Bulbus Allii is 1.040-1.090, Oleum Bulbus Allii index of refraction (25 ℃) is 1.559-1.579, the character of Oleum Bulbus Allii is yellow to the orange colour oily liquids, and acrid in the mouth is peppery, tool Bulbus Allii stink.This Oleum Bulbus Allii can both dissolve arbitrarily in chloroform, ether, benzene, toluene or dimethylbenzene, but insoluble in water.
With the prepared Oleum Bulbus Allii inclusion complex of mentioned component is white powder, and acrid in the mouth is peppery.Its water content must not surpass 8%, and its Oleum Bulbus Allii content must not be less than 80.40mg/g
Compound garlic oil capsule of the present invention be made up of compound garlic oil powder and capsule, and powder places in the capsule.It is characterized in that: the composition of this compound garlic oil capsule and components by weight percent ratio are:
Oleum Bulbus Allii inclusion complex 60-150,
Thallus Laminariae (Thallus Eckloniae) 70-200,
Semen Coicis 20-100,
The production method of this garlic oil capsule is:
Thallus Laminariae (Thallus Eckloniae), two kinds of compositions of Semen Coicis are washed with water respectively, dry, pulverize and make Thallus Laminariae (Thallus Eckloniae) fine powder, Semen Coicis fine powder then with prepared Oleum Bulbus Allii inclusion complex-white powdery, alternately join in the blender on a small quantity respectively, and stir while adding and reach mix homogeneously, the homogeneous mixture of gained is inserted in the capsule again.This compound garlic oil capsule is a capsule, and content is Oleum Bulbus Allii inclusion complex, Thallus Laminariae (Thallus Eckloniae), three kinds of mixture of ingredients of Semen Coicis-Lycoperdon polymorphum Vitt powder, and abnormal smells from the patient is pungent, but does not have the stink of Oleum Bulbus Allii.The contained Bulbus Allii oil mass of the content of this compound garlic oil capsule must not be less than 21.00mg/g.
Embodiment 1: the composition of compound garlic oil capsule and components by weight percent ratio are:
Oleum Bulbus Allii inclusion complex 60g
Thallus Laminariae (Thallus Eckloniae) 100g
Semen Coicis 20g
Embodiment 2: the composition of compound garlic oil capsule and components by weight percent ratio are:
Oleum Bulbus Allii inclusion complex 150g,
Thallus Laminariae (Thallus Eckloniae) 200g,
Semen Coicis 100g,
Embodiment 3: the composition of compound garlic oil capsule and components by weight percent ratio are:
Oleum Bulbus Allii inclusion complex 70g,
Thallus Laminariae (Thallus Eckloniae) 70g,
Semen Coicis 70g,
Embodiment 4: the composition of compound garlic oil capsule and components by weight percent ratio are:
Oleum Bulbus Allii inclusion complex 100g,
Thallus Laminariae (Thallus Eckloniae) 150g,
Semen Coicis 50g,
Method for making used among the embodiment 1-4 is with the above, and the contained Bulbus Allii oil mass of the content of prepared compound garlic oil capsule all is no less than 21.00mg/g.
Good effect of the present invention:
1, then garlic oil (beta-schardinger dextrin-) inclusion complex is equipped with kelp owing to garlic oil has been made " garlic oil (beta-schardinger dextrin-) inclusion complex " earlier, the compound preparation (compounding powder) that coix seed forms, preparation is inserted in the capsule, capsule 's content is to contain the non-oily liquids-compounding powder that enriches garlic oil, such compound garlic oil capsule has just solved: the medicinal curative effect that can keep garlic oil, eliminated again the garlic stink of garlic oil in the composition, that is: can't smell the garlic oil stink during compound garlic oil capsule natural storage, after taking exactly, beat mouth when coughing, also do not have the sense of the stink of garlic oil in the nasal cavity.
2, after compound garlic oil capsule is taken, has the capable stasis of blood merit turbid, that set upright invigorating the spleen of dispelling. The diseases such as hyperlipemia, atherosclerotic are had preferably curative effect, also can improve immunity of organisms, combined with chemotherapy is used for the auxiliary therapy of tumour patient. Simultaneously, garlic oil also has antibiotic, hypoglycemic, hypotensive activity. The composition of this compound garlic oil capsule consists of for the medicine-food two-purpose medicinal material, so this capsule also can be used as the daily health medicine of people.
When 3, compound garlic oil capsule is produced raw material extensively, be easy to get, preparation method is also uncomplicated, cost is also not high.
Note, the clinical research raw material (medical material) and the adjuvant of medicine
(1), Bulbus Allii is the bulb of liliaceous plant Bulbus Allii AIIiumsativumL..Gather summer, removes silt, the dry in the sun or be baked to the crust drying of facining the wind.
This product meets " 77 editions 38 pages of regulations of Chinese pharmacopoeia.
(2), Thallus Laminariae (Thallus Eckloniae) is the dry thallus of Laminariaceae plant Thallus Laminariae (Thallus Eckloniae) LaminariajaponicaAresch. or Alariaceae plant Thallus Laminariae (Thallus Eckloniae) EckIoniakuromeOkam..Summer, Qiu Erji fish, and dry.
This product meets " 90 editions 182 pages of regulations of Chinese pharmacopoeia.
(3), Semen Coicis is undergraduate course plant Semen Coicis CoixIacryma-jobiIL.var.ma-yuen(Roman.) dry mature kernal of Stapf.Tap plant during fruit maturation autumn, dries, and lays fruit, dries again, removes decapsidate, yellowish-brown kind skin and impurity, collects kernel.
This product meets " 90 editions 339 pages of regulations of Chinese pharmacopoeia.
(4), beta-schardinger dextrin-CycIodextrin(β-CD)
The used beta-schardinger dextrin-of this product is that capital, Yunan County, Guangdong Province cyclodextrin factory produces, authentication code (88), and the accurate word of medicine G-11 is defended in Guangdong
Product standard: Q/WS-2134-88
(5), Oleum Bulbus Allii, Zhongmou County, Zhengzhou bioid factory produces.
Claims (4)
1, a kind of compound garlic oil capsule is made up of compound garlic oil powder and capsule, and powder places in the capsule, and it is characterized in that: the composition of this compound garlic oil capsule and components by weight percent ratio are:
The Oleum Bulbus Allii inclusion complex, 60-150
Thallus Laminariae (Thallus Eckloniae) 70-200
Semen Coicis 20-100
2, the production method of compound garlic oil capsule according to claim 1 is: Thallus Laminariae (Thallus Eckloniae), two kinds of compositions of Semen Coicis wash with water respectively, dry, pulverize make Thallus Laminariae (Thallus Eckloniae) fine powder, Semen Coicis fine powder then with prepared Oleum Bulbus Allii inclusion complex-powdery, alternately join in the blender on a small quantity respectively, and stir while adding and reach mix homogeneously, the homogeneous mixture of gained is inserted in the capsule again.
3, compound garlic oil capsule according to claim 1 is characterized in that the Oleum Bulbus Allii content of said Oleum Bulbus Allii inclusion complex must not be less than 80.40mg/g.
4, compound garlic oil capsule according to claim 1 is characterized in that composition, ratio of component, the manufacture method of said Oleum Bulbus Allii inclusion complex is:
Beta-schardinger dextrin-75-150g
Oleum Bulbus Allii 15ml
Distilled water 300ml
Method for making: get beta cyclodextrin (75-150g), adding 300ml water stirs in colloid mill, then in colloid mill, add the 15ml Oleum Bulbus Allii, colloid mill is fully milled mixed 5 minutes, obtain leaving standstill in pastel, the container, dry, wash with water, 40 ℃ of dryings, white cellular thing, promptly obtain the Oleum Bulbus Allii inclusion complex of white powder after pulverizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94108044A CN1054750C (en) | 1994-08-08 | 1994-08-08 | Compound garlic oil capsule and its producing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94108044A CN1054750C (en) | 1994-08-08 | 1994-08-08 | Compound garlic oil capsule and its producing method |
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| Publication Number | Publication Date |
|---|---|
| CN1107341A true CN1107341A (en) | 1995-08-30 |
| CN1054750C CN1054750C (en) | 2000-07-26 |
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ID=5033316
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94108044A Expired - Fee Related CN1054750C (en) | 1994-08-08 | 1994-08-08 | Compound garlic oil capsule and its producing method |
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| CN (1) | CN1054750C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102652792A (en) * | 2011-03-04 | 2012-09-05 | 中国中医科学院中医基础理论研究所 | Anti-cancer application of composition containing garlic oil, garlic total polysaccharide and garlic total saponin |
| CN106520396A (en) * | 2016-10-29 | 2017-03-22 | 袁春华 | Preparation method of strong decontamination grapefruit oil abrasive cleaner |
-
1994
- 1994-08-08 CN CN94108044A patent/CN1054750C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102652792A (en) * | 2011-03-04 | 2012-09-05 | 中国中医科学院中医基础理论研究所 | Anti-cancer application of composition containing garlic oil, garlic total polysaccharide and garlic total saponin |
| CN102652792B (en) * | 2011-03-04 | 2014-03-26 | 中国中医科学院中医基础理论研究所 | Anti-cancer application of composition containing garlic oil, garlic total polysaccharide and garlic total saponin |
| CN106520396A (en) * | 2016-10-29 | 2017-03-22 | 袁春华 | Preparation method of strong decontamination grapefruit oil abrasive cleaner |
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| Publication number | Publication date |
|---|---|
| CN1054750C (en) | 2000-07-26 |
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