CN110731510A - formula for improving activity of probiotic strains and preparation method thereof - Google Patents
formula for improving activity of probiotic strains and preparation method thereof Download PDFInfo
- Publication number
- CN110731510A CN110731510A CN201911106885.2A CN201911106885A CN110731510A CN 110731510 A CN110731510 A CN 110731510A CN 201911106885 A CN201911106885 A CN 201911106885A CN 110731510 A CN110731510 A CN 110731510A
- Authority
- CN
- China
- Prior art keywords
- solution
- parts
- sennoside
- barbaloin
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000006041 probiotic Substances 0.000 title claims abstract description 35
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 35
- 230000000694 effects Effects 0.000 title claims abstract description 23
- 230000000529 probiotic effect Effects 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 229940124513 senna glycoside Drugs 0.000 claims abstract description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000000843 powder Substances 0.000 claims abstract description 19
- 229930186851 sennoside Natural products 0.000 claims abstract description 18
- IPQVTOJGNYVQEO-KGFNBKMBSA-N sennoside A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC2=C1C(=O)C1=C(O)C=C(C(O)=O)C=C1[C@@H]2[C@H]1C2=CC(C(O)=O)=CC(O)=C2C(=O)C2=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C=CC=C21 IPQVTOJGNYVQEO-KGFNBKMBSA-N 0.000 claims abstract description 18
- AFHJQYHRLPMKHU-XXWVOBANSA-N Aloin Natural products O=C1c2c(O)cc(CO)cc2[C@H]([C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)c2c1c(O)ccc2 AFHJQYHRLPMKHU-XXWVOBANSA-N 0.000 claims abstract description 14
- AFHJQYHRLPMKHU-OSYMLPPYSA-N aloin A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-OSYMLPPYSA-N 0.000 claims abstract description 14
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000013336 milk Nutrition 0.000 claims abstract description 7
- 239000008267 milk Substances 0.000 claims abstract description 7
- 210000004080 milk Anatomy 0.000 claims abstract description 7
- 235000010378 sodium ascorbate Nutrition 0.000 claims abstract description 7
- 229960005055 sodium ascorbate Drugs 0.000 claims abstract description 7
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims abstract description 7
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 37
- 238000002156 mixing Methods 0.000 claims description 14
- 239000011259 mixed solution Substances 0.000 claims description 12
- 241001116389 Aloe Species 0.000 claims description 6
- 235000006693 Cassia laevigata Nutrition 0.000 claims description 6
- 241000522641 Senna Species 0.000 claims description 6
- 235000011399 aloe vera Nutrition 0.000 claims description 6
- 238000002390 rotary evaporation Methods 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 230000001580 bacterial effect Effects 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 description 5
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 238000003672 processing method Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000005095 gastrointestinal system Anatomy 0.000 description 1
- 230000007366 host health Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention relates to a formula for improving the activity of probiotic strains and a preparation method thereof, which is prepared by the following raw materials of, by weight, 5 parts of sennoside solution, 1 part of barbaloin solution, 10 parts of milk powder, 0.5 part of brown sugar, 0.5 to 2.5 parts of glycerol, 0.3 to 1.5 parts of sodium ascorbate and 10 parts of pure water.
Description
Technical Field
The invention relates to the field of food engineering, in particular to a formula for improving the activity of probiotic strains and a processing method thereof.
Background
The probiotics mean live bacteria beneficial to the health of a host or dead bacteria or metabolites with the same physiological action as the live bacteria, after being taken properly, the microorganisms beneficial to the health of the host are needed by each gastrointestinal system, and when the probiotics enter a human body, the current probiotic products are mostly dead bacteria, the activity degree of the probiotics is low, if more active probiotics are taken into the human body, the probiotics can help the host to maintain the health more quickly, and the active bacteria can be utilized to realize high-efficiency absorption and decomposition in vivo.
The invention provides formulas and processing methods which have simple formula, no toxic or side effect and simple and easy preparation method and obviously improve the activity of probiotic strains.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides formulas and processing methods which are simple in formula, free of toxic and side effects, simple and easy to operate in preparation methods and capable of obviously improving the activity of probiotic strains, and aims to overcome the defects in the prior art.
The technical scheme is that the formula for improving the activity of the probiotic strains is , and the formula is prepared from the following raw materials, by weight, 5 parts of sennoside solution, 1 part of barbaloin solution, 10 parts of milk powder, 0.5 part of brown sugar, 0.5 to 2.5 parts of glycerol, 0.3 to 1.5 parts of sodium ascorbate and 10 parts of pure water.
The sennoside content in the sennoside solution is 20%, and the content of the barbaloin in the barbaloin solution is 20%.
A process for preparing a formulation for increasing the activity of a probiotic bacterial strain, the process comprising the steps of:
1) weighing senna leaf powder, soaking the senna leaf powder at the temperature of 80 ℃ for 2-3 hours, then collecting an extracting solution, and carrying out vacuum rotary evaporation on the extracting solution to obtain sennoside solution in parts by weight;
2) weighing dry aloe powder, soaking the dry aloe powder at 80 ℃ for 2-3 hours, collecting an extracting solution, and performing vacuum rotary evaporation on the extracting solution to prepare an barbaloin solution in parts by weight;
3) mixing the sennoside solution obtained in the step 1) and the step 2) with the barbaloin solution to obtain a mixed solution A;
4) mixing the milk powder, the brown sugar, the glycerol, the sodium ascorbate and the pure water in parts by weight, sterilizing at high temperature for 30 minutes after mixing, and cooling to obtain a mixed solution B;
5) and (3) mixing the mixed solution A in the step 3) with the mixed solution B in the step 4) to obtain a finished product.
The invention has the following positive effects: the addition is implemented during the preparation of the probiotic product, the mixing of the finished product and the probiotic strains is utilized to ensure that the probiotics has higher activity in the intestinal tract so that the strains are well wrapped after the active probiotics are orally taken, even after the probiotics pass through the stomach organ in an extremely acid environment and the action of bile acid salt secreted by the gall bladder, the probiotics can still keep the activity, so that the probiotics generate the due functions and effects.
Detailed Description
formula for improving activity of probiotic strains, which is prepared from the following raw materials, by weight, 5 parts of sennoside solution, 1 part of barbaloin solution, 10 parts of milk powder, 0.5 part of brown sugar, 0.5-2.5 parts of glycerol, 0.3-1.5 parts of sodium ascorbate and 10 parts of pure water, wherein the content of the sennoside in the sennoside solution is 20%, and the content of the barbaloin in the sennoside solution is 20%.
A process for preparing a formulation for increasing the activity of a probiotic bacterial strain, the process comprising the steps of:
1) weighing senna leaf powder, soaking the senna leaf powder at the temperature of 80 ℃ for 2-3 hours, then collecting an extracting solution, and carrying out vacuum rotary evaporation on the extracting solution to obtain sennoside solution in parts by weight;
2) weighing dry aloe powder, soaking the dry aloe powder at 80 ℃ for 2-3 hours, collecting an extracting solution, and performing vacuum rotary evaporation on the extracting solution to prepare an barbaloin solution in parts by weight;
3) mixing the sennoside solution obtained in the step 1) and the step 2) with the barbaloin solution to obtain a mixed solution A;
4) mixing the milk powder, the brown sugar, the glycerol, the sodium ascorbate and the pure water in parts by weight, sterilizing at high temperature for 30 minutes after mixing, and cooling to obtain a mixed solution B;
5) and (3) mixing the mixed solution A in the step 3) with the mixed solution B in the step 4) to obtain a finished product.
The addition is implemented during the preparation of the probiotic product, the mixing of the finished product and the probiotic strains is utilized to ensure that the probiotics has higher activity in the intestinal tract so that the strains are well wrapped after the active probiotics are orally taken, even after the probiotics pass through the stomach organ in an extremely acid environment and the action of bile acid salt secreted by the gall bladder, the probiotics can still keep the activity, so that the probiotics generate the due functions and effects.
Tests show that the probiotic product prepared by fermenting the probiotic by using the product has the activity amount of 20cfu/ml after gastric juice cleaning and bile acid salt cleaning.
The foregoing is directed to preferred embodiments of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow. However, any simple modification, equivalent change and modification of the above embodiments according to the technical essence of the present invention are within the protection scope of the technical solution of the present invention.
Claims (3)
- The formula for improving the activity of the probiotic strains is 1, and is characterized in that the formula is prepared from the following raw materials, by weight, 5 parts of sennoside solution, 1 part of barbaloin solution, 10 parts of milk powder, 0.5 part of brown sugar, 0.5 to 2.5 parts of glycerol, 0.3 to 1.5 parts of sodium ascorbate and 10 parts of pure water.
- 2. The formulation for improving the activity of a probiotic bacterial strain according to claim 1, wherein the sennoside content of the sennoside solution is 20%, and the barbaloin content of the sennoside solution is 20%.
- A process for preparing a formulation for increasing the activity of a probiotic bacterial strain according to claim 1, wherein the process comprises the steps of:1) weighing senna leaf powder, soaking the senna leaf powder at the temperature of 80 ℃ for 2-3 hours, then collecting an extracting solution, and carrying out vacuum rotary evaporation on the extracting solution to obtain sennoside solution in parts by weight;2) weighing dry aloe powder, soaking the dry aloe powder at 80 ℃ for 2-3 hours, collecting an extracting solution, and performing vacuum rotary evaporation on the extracting solution to prepare an barbaloin solution in parts by weight;3) mixing the sennoside solution obtained in the step 1) and the step 2) with the barbaloin solution to obtain a mixed solution A;4) mixing the milk powder, the brown sugar, the glycerol, the sodium ascorbate and the pure water in parts by weight, sterilizing at high temperature for 30 minutes after mixing, and cooling to obtain a mixed solution B;5) and (3) mixing the mixed solution A in the step 3) with the mixed solution B in the step 4) to obtain a finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911106885.2A CN110731510A (en) | 2019-11-13 | 2019-11-13 | formula for improving activity of probiotic strains and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911106885.2A CN110731510A (en) | 2019-11-13 | 2019-11-13 | formula for improving activity of probiotic strains and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110731510A true CN110731510A (en) | 2020-01-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911106885.2A Pending CN110731510A (en) | 2019-11-13 | 2019-11-13 | formula for improving activity of probiotic strains and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN110731510A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113528419A (en) * | 2021-07-13 | 2021-10-22 | 镇江市天益生物科技有限公司 | Additive for improving activity of lactobacillus strain and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005060937A1 (en) * | 2003-12-23 | 2005-07-07 | Chr. Hansen A/S | Compressed tablets comprising viable probiotic microorganisms |
| CN105962377A (en) * | 2016-05-06 | 2016-09-28 | 华侨大学 | Preparation method of edible film carried and loaded with high-activity probiotics |
| CN107495049A (en) * | 2017-10-17 | 2017-12-22 | 广东达明益派生物科技有限公司 | Composition for probiotics fermention beverage made of fruits or vegetables of the preparation with function of relaxing bowel, beverage containing composition and preparation method thereof |
| CN108523137A (en) * | 2018-04-19 | 2018-09-14 | 江苏微康生物科技有限公司 | A kind of preparation method of the probiotic granulate of acid and bile salt tolerance |
| CN110050972A (en) * | 2019-03-12 | 2019-07-26 | 周黎明 | Aloe haw pellet and preparation method thereof |
-
2019
- 2019-11-13 CN CN201911106885.2A patent/CN110731510A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005060937A1 (en) * | 2003-12-23 | 2005-07-07 | Chr. Hansen A/S | Compressed tablets comprising viable probiotic microorganisms |
| CN105962377A (en) * | 2016-05-06 | 2016-09-28 | 华侨大学 | Preparation method of edible film carried and loaded with high-activity probiotics |
| CN107495049A (en) * | 2017-10-17 | 2017-12-22 | 广东达明益派生物科技有限公司 | Composition for probiotics fermention beverage made of fruits or vegetables of the preparation with function of relaxing bowel, beverage containing composition and preparation method thereof |
| CN108523137A (en) * | 2018-04-19 | 2018-09-14 | 江苏微康生物科技有限公司 | A kind of preparation method of the probiotic granulate of acid and bile salt tolerance |
| CN110050972A (en) * | 2019-03-12 | 2019-07-26 | 周黎明 | Aloe haw pellet and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李曼莎等: "益生菌与药食同源植物的协同作用", 《食品工业》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113528419A (en) * | 2021-07-13 | 2021-10-22 | 镇江市天益生物科技有限公司 | Additive for improving activity of lactobacillus strain and preparation method thereof |
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