CN110721249A - Preparation method of grape seed essence tablet - Google Patents
Preparation method of grape seed essence tablet Download PDFInfo
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- CN110721249A CN110721249A CN201911196919.1A CN201911196919A CN110721249A CN 110721249 A CN110721249 A CN 110721249A CN 201911196919 A CN201911196919 A CN 201911196919A CN 110721249 A CN110721249 A CN 110721249A
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Abstract
The invention discloses a method for preparing grape seed essence tablets, which comprises the steps of preparing materials, preparing a bonding agent, mixing, preparing a soft material, drying, QA intermediate control, granulating, total mixing, tabletting, QA sampling detection, coating, drying, QA sampling detection and packaging. The grape seed essence tablet prepared by the invention conforms to the pharmacopoeia of the people's republic of China and relevant national standard regulations, greatly improves the practicability, edibility and portability of the grape seeds, has great innovation on the eating of the grape seeds and promotes the beneficial effects of the grape seeds on human bodies; in the process of producing the grape seed essence piece, the boiling granulator used for drying the soft material can improve the quick drying of the soft material, reduce the problem of secondary accumulation of the soft material, improve the mutual fusion molding of all ingredients in the grape seed essence piece and improve the quality of the finished product grape seed essence piece.
Description
Technical Field
The invention relates to the technical field of health products, in particular to a method for preparing a grape seed essence tablet.
Background
Grape seeds are rich in anthocyanin, can remove free radicals, resist aging, enhance immunity and prevent substances from damaging human cells, and have the main functions of resisting free radicals, reducing blood fat, protecting skin and brain, resisting allergy, resisting radiation, protecting vascular tissues and the like, particularly has certain prevention effect on human organs and tissues and chronic diseases such as heart disease, diabetes, arteriosclerosis and the like. The anthocyanin in the eye mask can protect the eyes from radiation damage, enhance night vision capability, reduce retinopathy and the like, and can protect the digestive system and gastric mucosa of people and prevent and treat ulcer and various ulcerative diseases of people. At present, grape seeds are generally eaten directly to be digested and absorbed, and because the grape seeds are bitter in taste and hard, the grape seeds are difficult to eat by old people, children or bad teeth, and beneficial ingredients of the grape seeds are few, the grape seeds need to be treated, so that the grape seeds are convenient to eat and absorb.
Disclosure of Invention
Aiming at the problems, the invention aims to provide a method for preparing grape seed essence tablets, which is prepared by selecting different ingredients and methods, is convenient to eat and carry, and improves the practicability, absorbability and portability of grape seeds.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows: the preparation method of the grape seed essence tablet is characterized by comprising the following steps:
(1) stock preparation
Comprises grape seed extract, calcium ascorbate, microcrystalline cellulose 101, calcium hydrogen phosphate, polyvidone K30, crospovidone, silicon dioxide, magnesium stearate, coating powder and 95% ethanol; every 1000 grape seed essence tablets contain 90-110g of grape seed extract, 25-30g of calcium ascorbate, 300g of microcrystalline cellulose 101, 200g of calcium hydrophosphate, 15-25g of povidone K30, 40-60g of crospovidone, 5-8g of silicon dioxide, 5-8g of magnesium stearate, 15-25g of coating powder and 80-100g of 95% ethanol;
(2) adhesive preparation
Adding purified water into 95% ethanol to prepare 63% -67% ethanol adhesive;
(3) mixing
Adding grape seed extract, microcrystalline cellulose 101, calcium hydrogen phosphate with a stock amount of 1/2, and polyvidone K30 into a wet granulator, stirring at low speed by a stirring paddle of the wet granulator, cutting at low speed by a cutter, and mixing for 3-5min to obtain a mixture;
(4) soft material making
Keeping low-speed stirring of the mixture, adjusting the cutting knife to high-speed cutting, adding the prepared ethanol adhesive into the wet granulator at a constant speed, and mixing for 3-5min to obtain a soft material;
(5) drying
Drying the soft material in a boiling granulator or wet-granulating in a granule swing machine equipped with 16-18 mesh nylon screen, and drying in an oven to obtain dry granules;
(6) QA intermediate control
Carrying out quality detection on the dry particles through QA, wherein the LOD control range is 3-6%;
(7) whole grain
Finishing the dry particles after QA control by a 16-18 mesh screen or a 3-4# screen finishing machine to obtain particles to be mixed;
(8) total mixing
Pulverizing calcium ascorbate, sieving with 40 mesh sieve, mixing with 1/2 residual amounts of calcium hydrogen phosphate, crospovidone, silicon dioxide and total granules in a mixer for 20-30min, adding magnesium stearate, and continuously mixing for 5-10min to obtain grape seed granule;
(9) tabletting
Carrying out tabletting operation on the grape seed particles by using a tabletting mould to obtain grape seed tablets;
(10) QA sampling test
Randomly sampling grape seed pieces and carrying out the following item detection: the tablet weight is 653-;
(11) coating film
Preparing a coating solution: 1kg of coating powder, 4.5-4.8kg of 95% ethanol and 4.2-4.5mg of purified water, putting the grape seed slices into a coating pot, preheating until the bed temperature of the grape seed slices is 33-40 ℃, and coating with a coating solution to obtain grape seed essence tablets;
(12) drying by baking
Drying the coated grape seed essence tablet in an oven for 5-10min to ensure that the LOD of the grape seed essence tablet is less than 5%, and intermittently rolling a coating pan body to enable the grape seed essence tablet to reach room temperature;
(13) QA sampling test
Randomly selecting grape seed essence slices, and detecting by using a metal detector;
(14) package (I)
And packaging the grape seed essence tablets according to the requirements.
Preferably, in step (4), the addition of the ethanol binder takes 1 to 3 min.
Preferably, in step (5), the particles are spread in the oven to a thickness of 2-3cm, and the temperature is set at 60 ℃.
Preferably, in step (8), the mixing speed of the mixer is 10 r/min.
Preferably, in step (11), the coating weight of the grape seed tablet is increased by 3%, the solvent is 50% ethanol, and the solid content is 10%; the air inlet temperature of the coating is 60 +/-5 ℃, and the atomization pressure is as follows: 0.4 +/-0.1 MPa, and negative pressure difference in the cavity.
As a further improvement, in the step (5), the boiling granulator comprises a conical hopper and an auxiliary device, a stirring rod is arranged in the conical hopper, a stirring paddle is arranged at the bottom of the stirring rod, a pre-drying device is arranged at the top of the stirring rod, a feeding hole is arranged at the upper part of the side wall of the conical hopper, and the feeding hole extends into the conical hopper and is higher than the pre-drying device.
As a further improvement, the pre-drying device is of a bulk structure, and the surface of the pre-drying device is uniformly provided with particle perforations.
As a further improvement, an arc-shaped scraping plate is arranged at the end part of the stirring paddle, which is close to the side wall of the conical hopper.
As a further improvement, the edge of one side of the arc-shaped scraping plate, which is close to the inner wall of the conical hopper, is of an inclined structure and is parallel to the inner wall of the conical hopper.
As a further improvement, the arc-shaped scraping plate is obliquely arranged and forms an included angle with the stirring rod.
The invention has the beneficial effects that: (1) the grape seed essence tablet prepared by the invention conforms to the pharmacopoeia of the people's republic of China and relevant national standard regulations, greatly improves the practicability, edibility and portability of the grape seeds, has great innovation on the eating of the grape seeds and promotes the beneficial effects of the grape seeds on human bodies. (2) In the process of producing the grape seed essence piece, the boiling granulator used for drying the soft material can improve the quick drying of the soft material, reduce the problem of secondary accumulation of the soft material, improve the mutual fusion molding of all ingredients in the grape seed essence piece and improve the quality of the finished product grape seed essence piece.
Drawings
Fig. 1 is a schematic view of the whole structure of the boiling granulator.
FIG. 2 is a cross-sectional structural view of a conical hopper according to the present invention.
FIG. 3 is a top view of the stirring blade of the present invention.
FIG. 4 is a top view of the pre-drying apparatus according to the present invention.
FIG. 5 is an enlarged view of FIG. 2A of the present invention.
Wherein: 1-conical hopper, 2-feeding port, 3-house type scraper plate, 4-hot air system, 11-stirring rod, 12-stirring paddle, 13-predrying device and 131-particle perforation.
Detailed Description
In order to make those skilled in the art better understand the technical solution of the present invention, the following further describes the technical solution of the present invention with reference to the drawings and the embodiments.
Example one
The preparation method of the grape seed essence tablet comprises the following steps:
(1) stock preparation
Selecting 95g of grape seed extract, 25.5g of calcium ascorbate, 270.5g of microcrystalline cellulose 101, 165g of calcium hydrogen phosphate, 20g of povidone K30, 45g of crospovidone, 6g of silicon dioxide, 7g of magnesium stearate, 18g of coating powder and 100g of 95% ethanol in each 1000 tablets;
(2) adhesive preparation
50g of purified water is added into 95% ethanol to prepare 150g of 65% ethanol adhesive;
(3) mixing
Adding grape seed extract, microcrystalline cellulose 101, 82.5g of calcium hydrogen phosphate, and polyvidone K30 into wet granulator, stirring at low speed by stirring paddle of wet granulator, cutting at low speed by cutter, mixing for 4min, and mixing to obtain mixture;
(4) soft material making
Continuously stirring the mixture at low speed by the wet granulator, adjusting the cutting knife to high speed cutting, adding appropriate amount of prepared ethanol adhesive into the wet granulator at constant speed, adding ethanol adhesive for 3min, mixing for 4min, and completely mixing to obtain soft material;
(5) drying
Putting the soft material into a boiling granulator and drying to obtain dry granules;
or wet finishing in a granule swinging machine equipped with 16 mesh nylon screen, drying in an oven, spreading the granules in the oven with a thickness of 3cm, setting the temperature at 60 deg.C, and drying to obtain dry granules;
(6) QA intermediate control
Carrying out quality detection on the dry particles by QA, wherein the LOD detection value range is 4-5%;
(7) whole grain
Sieving qualified dry granules with 16 mesh sieve to obtain mixed granules
Or granulating by a No. 3 sieve granulator to obtain granules to be mixed, and crushing the coarse granules;
(8) total mixing
Pulverizing calcium ascorbate, sieving with 40 mesh sieve, mixing with the rest 82.5g of calcium hydrogen phosphate, crospovidone, silicon dioxide and granules to be mixed in a mixer for 20min, adding magnesium stearate again, and continuously mixing for 5-10min at the mixing speed of preferably 10r/min to obtain grape seed granules, preferably 2/3 (the volume of the granules accounts for the total volume of the mixer);
(9) tabletting
Tabletting the grape seed particles by using a tabletting mould, wherein the punch is round, the length of the punch is 16.20mm, the width of the punch is 7.30mm, the code of the mould is MG-028, and the grape seed pieces are obtained after tabletting by using the mould;
(10) QA sampling test
Randomly sampling grape seed pieces and carrying out the following item detection: the tablet weight is about 680mg, the thickness is about 6.5mm, the hardness is about 120N, the friability is about 0.4%, and the disintegration time is about 20min, all of which meet the detection conditions;
(11) coating film
Preparing a coating solution: 1kg of coating powder, 4.6kg of 95% ethanol and 4.2mg of purified water, putting the grape seed slices into a coating pot, preheating the grape seed slices to the temperature of 33-40 ℃ in a grape seed slice bed, coating by using a coating solution, wherein the coating weight of the grape seed slices is increased by 3%, the solvent is 50% ethanol, the solid content is 10%, the air inlet temperature of the coating is 60 ℃, the atomizing pressure is 0.4Mpa, and the pressure difference of a cavity is negative pressure, and coating is carried out to obtain the grape seed essence tablets;
(12) drying by baking
Drying the coated grape seed essence tablet in an oven for 8min, wherein the LOD of the grape seed essence tablet is 4%, and intermittently rolling a coating pan body to enable the grape seed essence tablet to reach room temperature;
(13) QA sampling test
Randomly selecting grape seed essence slices, and detecting by using a metal detector;
(14) package (I)
The grape seed essence tablets are packaged according to requirements, 3000 granules/bag, 2 bags/middle box and 4 middle box/box.
Referring to fig. 1-5, a further improvement is: the boiling granulator comprises a conical hopper 1 and an auxiliary device, wherein a stirring rod 11 is arranged in the conical hopper 1, a stirring paddle 12 is arranged at the bottom of the stirring rod 11, a pre-drying device 13 is arranged at the top of the stirring rod, a feeding hole 2 is arranged on the upper portion of the side wall of the conical hopper 1, the feeding hole 2 extends into the conical hopper 1 and is higher than the pre-drying device 13, during drying, soft materials enter the conical hopper 1 from the feeding hole 2 through negative pressure and fall onto the pre-drying device 13, the stirring rod 11 drives the pre-drying device 13 to rotate, the soft materials entering the conical hopper 1 from the feeding hole 2 are flatly spread on the surface of the pre-drying device 13 in a rotating manner, the soft materials are prevented from being accumulated on the surface of the pre-drying device 13, the flatly spread soft materials are subjected to rotary centrifugation through the rotating effect, and fall down along the inner wall through a gap between the pre-drying device 13 and the, the softwood is dried through boiling granulator's hot air system 4 to the softwood, predrying device 13 has solved the softwood and has piled up the problem in toper hopper bottom after getting into the toper hopper through feed inlet 2, and solved accumulational softwood under the condition of not in time drying, pile up into bigger softwood problem more easily, predrying device 13 also can improve boiling granulator hot air system 4 and ventilate smoothly, easily dry the softwood, very big improvement the drying effect of softwood and the problem of having solved the boiling granulator existence.
The further improvement lies in that: the pre-drying device 13 is of an umbrella-shaped structure, the particle through holes 131 are uniformly distributed on the surface of the pre-drying device, the umbrella-shaped structure is convenient for soft materials to slide down by the gravity of the soft materials, and the accumulation of the soft materials on the surface of the pre-drying device 13 can be reduced; and granule perforation 131 is convenient for separate the softwood through predrying device 13, reduces its piling up through toper hopper 1 inner wall clearance, and hot air system 4 can be better simultaneously carries out the drying to the softwood through granule perforation 131, very big improvement drying effect.
The further improvement lies in that: the stirring rake 12 is equipped with the arc on being close to the tip of 1 lateral wall of toper hopper and scrapes flitch 3, scrapes flitch 3 through this arc and can prevent that the softwood from gluing on 1 inner wall of toper hopper at the rotatory extruded in-process of stirring rake 12, and influence the stirring of stirring rake 12, and simultaneously, this arc scrapes flitch 3 and can improve the stirring effect of stirring rake 12, and the abundant drying of hot air system 4 to the softwood of being convenient for.
The further improvement lies in that: the arc scrapes flitch 3 and is close to 1 inner wall of toper hopper side edge and establishes to the slope structure, and parallel with 1 inner wall of toper hopper, and this slope structure and 1 inner wall parallel arrangement of toper hopper can be better strike off the softwood on 1 inner wall of toper hopper.
The further improvement lies in that: the arc scraping plates 3 are obliquely arranged and form an included angle with the stirring rod 11, preferably, the included angle is 8-10 degrees, the arc scraping plates 3 are obliquely arranged, the soft material at the bottom of the conical hopper 1 can be conveniently stirred and dispersed upwards, and the drying of the soft material by the hot air system 4 is facilitated.
The following is an example bill of materials and inspection report:
the bill of materials is as follows:
| numbering | Material code | Material(s) | Content per tablet/mg(1) |
The feed amount per thousand tablets per |
| 1 | Y00187 | Grape with multiple layers of different shapesSeed of cornExtract of plant | 100 | 95 |
| 2 | Y00359 | Ascorbic acid calcium salt | 28.61 | 25.5 |
| 3 | F00053 | Microcrystalline cellulose 101 | 286.79 | 270.5 |
| 4 | Y00151 | Calcium hydrogen phosphate | 180 | 165(2) |
| 5 | Y00105 | PovidoneK30 | 21 | 20 |
| 6 | Y00411 | Cross-linkingPovidone | 50 | 45 |
| 7 | F00037 | Silicon dioxide | 6.8 | 6 |
| 8 | F00078 | Magnesium stearate | 6.8 | 7 |
| 9 | F00121 | Coating powder | 20 | 18 |
| 10 | W00001 | 95% ethanol | 96 | 100 |
The test is reported as follows:
example two
The preparation method of the grape seed essence tablet comprises the following steps:
(1) stock preparation
Selecting 100g of grape seed extract, 28.61g of calcium ascorbate, 286.79g of microcrystalline cellulose 101, 180g of calcium hydrophosphate, 21g of povidone K30, 50g of crospovidone, 6.8g of silicon dioxide, 6.8g of magnesium stearate, 20g of coating powder and 96g of 95% ethanol in every 1000 tablets;
(2) adhesive preparation
Adding 44g of purified water into 95% ethanol to prepare 140g of 65% ethanol adhesive;
(3) mixing
Adding grape seed extract, microcrystalline cellulose 101, 90g of calcium hydrogen phosphate, and polyvidone K30 into wet granulator, stirring at low speed by stirring paddle of wet granulator, cutting at low speed by cutter, mixing for 5min, and mixing to obtain mixture;
(4) soft material making
Continuously stirring the mixture at low speed by the wet granulator, adjusting the cutting knife to high speed cutting, adding appropriate amount of prepared ethanol adhesive into the wet granulator at constant speed, adding ethanol adhesive for 2.5min, mixing for 4min, and mixing completely to obtain soft material;
(5) drying
Putting the soft material into a boiling granulator and drying to obtain dry granules;
or wet finishing in a granule swinging machine equipped with 18-mesh nylon screen, drying in an oven, spreading the granules in the oven with a thickness of 3cm, setting the temperature at 60 deg.C, and drying to obtain dry granules;
(6) QA intermediate control
Carrying out quality detection on the dry particles by QA, wherein the LOD detection value range is 4-5%;
(7) whole grain
Sieving qualified dry granules with 16 mesh sieve to obtain mixed granules
Or granulating by a No. 3 sieve granulator to obtain granules to be mixed, and crushing the coarse granules;
(8) total mixing
Pulverizing calcium ascorbate, sieving with 40 mesh sieve, mixing with the rest 90g of calcium hydrogen phosphate, crospovidone, silicon dioxide and the granules to be mixed in a mixer for 20min, adding magnesium stearate again, and continuously mixing for 10min, wherein the mixing speed of the mixer is preferably 10r/min, and mixing to obtain grape seed granules, preferably 2/3 (the volume of the granules accounts for the total volume of the mixer);
(9) tabletting
Tabletting the grape seed particles by using a tabletting mould, wherein the punch is round, the length of the punch is 16.20mm, the width of the punch is 7.30mm, the code of the mould is MG-028, and the grape seed pieces are obtained after tabletting by using the mould;
(10) QA sampling test
Randomly sampling grape seed pieces and carrying out the following item detection: the tablet weight is about 695mg, the thickness is about 6.6mm, the hardness is about 125N, the friability is about 0.45%, and the disintegration time is about 23min, all of which meet the detection conditions;
(11) coating film
Preparing a coating solution: 1kg of coating powder, 4.74kg of 95% ethanol and 4.26mg of purified water, putting the grape seed slices into a coating pot, preheating to 36 ℃ of a grape seed slice bed, coating by using a coating solution, wherein the coating weight of the grape seed slices is increased by 3.2%, the solvent is 50% ethanol, the solid content is 10.3%, the coating air inlet temperature is 63 ℃, the atomizing pressure is 0.45Mpa, and the pressure difference of a cavity is negative pressure, and coating is carried out to obtain the grape seed essence tablets;
(12) drying by baking
Drying the coated grape seed essence tablet in an oven for 8min, wherein the LOD of the grape seed essence tablet is 4.2%, and intermittently rolling a coating pan body to enable the grape seed essence tablet to reach the room temperature;
(13) QA sampling test
Randomly selecting grape seed essence slices, and detecting by using a metal detector;
(14) package (I)
Packaging the grape seed essence tablets according to requirements, wherein 3000 granules/bag, 2 bags/middle box and 4 middle boxes/box are packaged;
in step (5), the boiling granulator used for drying the soft material is the same as that used in the first embodiment.
The following are the example two bill of materials and inspection reports:
the bill of materials is as follows:
| numbering | Material code | Material(s) | Content per tablet/mg(1) |
The feed amount per thousand tablets per |
| 1 | Y00187 | GrapeSeed of cornExtract of plant | 100 | 100 |
| 2 | Y00359 | Ascorbic acid calcium salt | 28.61 | 28.61 |
| 3 | F00053 | Microcrystalline cellulose 101 | 286.79 | 286.79 |
| 4 | Y00151 | Calcium hydrogen phosphate | 180 | 180(2) |
| 5 | Y00105 | PovidoneK30 | 21 | 21 |
| 6 | Y00411 | Cross-linkingPovidone | 50 | 50 |
| 7 | F00037 | Silicon dioxide | 6.8 | 6.8 |
| 8 | F00078 | Magnesium stearate | 6.8 | 6.8 |
| 9 | F00121 | Coating powder | 20 | 20 |
| 10 | W00001 | 95% ethanol | 96 | 96 |
The test is reported as follows:
EXAMPLE III
The preparation method of the grape seed essence tablet comprises the following steps:
(1) stock preparation
Selecting 105g of grape seed extract, 29g of calcium ascorbate, 290g of microcrystalline cellulose 101, 190g of calcium hydrogen phosphate, 24g of povidone K30, 55g of crospovidone, 7g of silicon dioxide, 7g of magnesium stearate, 22g of coating powder and 96g of 95% ethanol in each 1000 tablets;
(2) adhesive preparation
Adding 44g of purified water into 95% ethanol to prepare 140g of 65% ethanol adhesive;
(3) mixing
Adding grape seed extract, microcrystalline cellulose 101, 95g of calcium hydrogen phosphate, and polyvidone K30 into wet granulator, stirring at low speed by stirring paddle of wet granulator, cutting at low speed by cutter, mixing for 4.5min, and mixing to obtain mixture;
(4) soft material making
Continuously stirring the mixture at low speed by the wet granulator, adjusting the cutting knife to high speed cutting, adding appropriate amount of prepared ethanol adhesive into the wet granulator at constant speed, adding ethanol adhesive for 3min, mixing for 5min, and completely mixing to obtain soft material;
(5) drying
Putting the soft material into a boiling granulator and drying to obtain dry granules;
or wet finishing in a granule swinging machine equipped with 18-mesh nylon screen, drying in an oven, spreading the granules in the oven with a thickness of 3cm, setting the temperature at 60 deg.C, and drying to obtain dry granules;
(6) QA intermediate control
Carrying out quality detection on the dry particles by QA, wherein the LOD detection value range is 4-5%;
(7) whole grain
Sieving qualified dry granules with 18 mesh sieve to obtain mixed granules
Or granulating by a No. 3 sieve granulator to obtain granules to be mixed, and crushing the coarse granules;
(8) total mixing
Pulverizing calcium ascorbate, sieving with 40 mesh sieve, mixing with the rest 95g of calcium hydrogen phosphate, crospovidone, silicon dioxide and the granules to be mixed in a mixer for 22min, adding magnesium stearate again, and continuously mixing for 10min, wherein the mixing speed of the mixer is preferably 10r/min, and mixing to obtain grape seed granules, preferably 2/3 (the volume of the granules accounts for the total volume of the mixer);
(9) tabletting
Tabletting the grape seed particles by using a tabletting mould, wherein the punch is round, the length of the punch is 16.20mm, the width of the punch is 7.30mm, the code of the mould is MG-028, and the grape seed pieces are obtained after tabletting by using the mould;
(10) QA sampling test
Randomly sampling grape seed pieces and carrying out the following item detection: the tablet weight is about 700mg, the thickness is about 6.5mm, the hardness is about 124N, the friability is about 0.47%, and the disintegration time is about 24min, all of which meet the detection conditions;
(11) coating film
Preparing a coating solution: 1kg of coating powder, 4.8kg of 95% ethanol and 4.3mg of purified water, putting the grape seed slices into a coating pot, preheating the grape seed slices to 40 ℃, coating by using a coating solution, wherein the coating weight of the grape seed slices is increased by 3.5%, the solvent is 50% ethanol, the solid content is 10.4%, the air inlet temperature of the coating is 61 ℃, the atomizing pressure is 0.43Mpa, and the pressure difference of a cavity is negative pressure, and coating is carried out to obtain grape seed essence tablets;
(12) drying by baking
Drying the coated grape seed essence tablet in an oven for 8min, wherein the LOD of the grape seed essence tablet is 4.5%, and intermittently rolling a coating pan body to enable the grape seed essence tablet to reach the room temperature;
(13) QA sampling test
Randomly selecting grape seed essence slices, and detecting by using a metal detector;
(14) package (I)
Packaging the grape seed essence tablets according to requirements, wherein 3000 granules/bag, 2 bags/middle box and 4 middle boxes/box are packaged;
in step (5), the boiling granulator used for drying the soft material is the same as that used in the first embodiment.
The following are the three bill of materials and inspection reports for the example:
the bill of materials is as follows:
| numbering | Material code | Material(s) | Content per tablet/mg(1) |
The feed amount per thousand tablets per |
| 1 | Y00187 | GrapeSeed of cornExtract of plant | 100 | 105 |
| 2 | Y00359 | Ascorbic acid calcium salt | 28.61 | 29 |
| 3 | F00053 | Microcrystalline cellulose 101 | 286.79 | 290 |
| 4 | Y00151 | Calcium hydrogen phosphate | 180 | 190(2) |
| 5 | Y00105 | PovidoneK30 | 21 | 24 |
| 6 | Y00411 | Cross-linkingPovidone | 50 | 55 |
| 7 | F00037 | Silicon dioxide | 6.8 | 7 |
| 8 | F00078 | Magnesium stearate | 6.8 | 7 |
| 9 | F00121 | Coating powder | 20 | 22 |
| 10 | W00001 | 95% ethanol | 96 | 96 |
The test is reported as follows:
the following are the production data of examples one to three:
in addition, the specific operation steps of metal detection in the first embodiment to the third embodiment are as follows:
operation of the metal detector:
1.1 strictly distinguishing the non-gold detection products from the gold detection products;
1.2 Using a stainless steel sugar spatula, slowly pour product into a metal detector (stainless steel test module 0.51mm), noting that the flow rate was 1 g/tablet 10 tablets while passing through the sensing zone. According to the test sensitivity of the stainless steel test module of 0.51mm, when in test, an alarm indicates that the product has a metal foreign body, the gold detection is determined to be unqualified, and when the test fails, the product can be determined to be qualified;
1.3 products with metal foreign matter risk are independently removed by equipment, and the removed products are strictly separated and discarded;
when equipment alarms, the operation is immediately stopped, alarm reasons are analyzed and timely processed, and if the alarm is that unqualified products fall into qualified products, all the qualified products which pass the gold inspection machine need to be subjected to gold inspection again.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. The preparation method of the grape seed essence tablet is characterized by comprising the following steps:
(1) stock preparation
Comprises grape seed extract, calcium ascorbate, microcrystalline cellulose 101, calcium hydrogen phosphate, polyvidone K30, crospovidone, silicon dioxide, magnesium stearate, coating powder and 95% ethanol; every 1000 grape seed essence tablets contain 90-110g of grape seed extract, 25-30g of calcium ascorbate, 300g of microcrystalline cellulose 101, 200g of calcium hydrophosphate, 15-25g of povidone K30, 40-60g of crospovidone, 5-8g of silicon dioxide, 5-8g of magnesium stearate, 15-25g of coating powder and 80-100g of 95% ethanol;
(2) adhesive preparation
Adding purified water into 95% ethanol to prepare 63% -67% ethanol adhesive;
(3) mixing
Adding grape seed extract, microcrystalline cellulose 101, calcium hydrogen phosphate with a stock amount of 1/2, and polyvidone K30 into a wet granulator, stirring at low speed by a stirring paddle of the wet granulator, cutting at low speed by a cutter, and mixing for 3-5min to obtain a mixture;
(4) soft material making
Keeping low-speed stirring of the mixture, adjusting the cutting knife to high-speed cutting, adding the prepared ethanol adhesive into the wet granulator at a constant speed, and mixing for 3-5min to obtain a soft material;
(5) drying
Drying the soft material in a boiling granulator or wet-granulating in a granule swing machine equipped with 16-18 mesh nylon screen, and drying in an oven to obtain dry granules;
(6) QA intermediate control
Carrying out quality detection on the dry particles through QA, wherein the LOD control range is 3-6%;
(7) whole grain
Finishing the dry particles after QA control by a 16-18 mesh screen or a 3-4# screen finishing machine to obtain particles to be mixed;
(8) total mixing
Pulverizing calcium ascorbate, sieving with 40 mesh sieve, mixing with 1/2 residual amounts of calcium hydrogen phosphate, crospovidone, silicon dioxide and total granules in a mixer for 20-30min, adding magnesium stearate, and continuously mixing for 5-10min to obtain grape seed granule;
(9) tabletting
Carrying out tabletting operation on the grape seed particles by using a tabletting mould to obtain grape seed tablets;
(10) QA sampling test
Randomly sampling grape seed pieces and carrying out the following item detection: the tablet weight is 653-;
(11) coating film
Preparing a coating solution: 1kg of coating powder, 4.5-4.8kg of 95% ethanol and 4.2-4.5mg of purified water, putting the grape seed slices into a coating pot, preheating until the bed temperature of the grape seed slices is 33-40 ℃, and coating with a coating solution to obtain grape seed essence tablets;
(12) drying by baking
Drying the coated grape seed essence tablet in an oven for 5-10min to ensure that the LOD of the grape seed essence tablet is less than 5%, and intermittently rolling a coating pan body to enable the grape seed essence tablet to reach room temperature;
(13) QA sampling test
Randomly selecting grape seed essence slices, and detecting by using a metal detector;
(14) package (I)
And packaging the grape seed essence tablets according to the requirements.
2. The method for preparing the grape seed essence sheet according to claim 1, wherein the method comprises the following steps: in step (4), the time taken for adding the ethanol binder is 1-3 min.
3. The method for preparing the grape seed essence sheet according to claim 2, wherein the method comprises the following steps: in the step (5), the particles in the oven are spread to be 2-3cm in thickness, and the temperature is set to be 60 ℃.
4. The method for preparing the grape seed essence sheet according to claim 3, wherein the method comprises the following steps: in the step (8), the mixing speed of the mixer is 10 r/min.
5. The method for preparing the grape seed essence sheet according to claim 4, wherein the method comprises the following steps: in the step (11), the coating weight of the grape seed tablet is increased by 3%, the solvent is 50% ethanol, and the solid content is 10%; the air inlet temperature of the coating is 60 +/-5 ℃, and the atomization pressure is as follows: 0.4 +/-0.1 MPa, and negative pressure difference in the cavity.
6. The method for preparing the grape seed essence sheet according to claim 5, wherein the method comprises the following steps: in step (5), the boiling granulator comprises a conical hopper and an auxiliary device, wherein a stirring rod is arranged in the conical hopper, a stirring paddle is arranged at the bottom of the stirring rod, a pre-drying device is arranged at the top of the stirring rod, a feeding hole is formed in the upper portion of the side wall of the conical hopper, and the feeding hole extends into the conical hopper and is higher than the pre-drying device.
7. The method for preparing the grape seed essence sheet according to claim 6, wherein the method comprises the following steps: the pre-drying device is of a bulk structure, and particle perforations are uniformly distributed on the surface of the pre-drying device.
8. The method for preparing the grape seed essence sheet according to claim 7, wherein the method comprises the following steps: and an arc-shaped scraping plate is arranged at the end part of the stirring paddle, which is close to the side wall of the conical hopper.
9. The method for preparing the grape seed essence sheet according to claim 8, wherein the method comprises the following steps: the edge of one side of the arc-shaped scraping plate, which is close to the inner wall of the conical hopper, is arranged to be of an inclined structure and is parallel to the inner wall of the conical hopper.
10. The method for preparing the grape seed essence sheet according to claim 9, wherein the method comprises the following steps: the arc scraping plate is obliquely arranged and forms an included angle with the stirring rod.
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| CN103099205A (en) * | 2013-02-21 | 2013-05-15 | 汤臣倍健股份有限公司 | Grape seed tablet and preparation method thereof |
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| CN103099205A (en) * | 2013-02-21 | 2013-05-15 | 汤臣倍健股份有限公司 | Grape seed tablet and preparation method thereof |
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| CN115219306A (en) * | 2022-08-15 | 2022-10-21 | 南京派诺思科学仪器有限公司 | Standard substance for disintegration time limit test and preparation and test methods thereof |
| CN115219306B (en) * | 2022-08-15 | 2022-12-09 | 南京派诺思科学仪器有限公司 | Standard substance for disintegration time limit test and preparation and test methods thereof |
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