CN110711493A - Adsorption membrane, composite membrane module and filter - Google Patents

Adsorption membrane, composite membrane module and filter Download PDF

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Publication number
CN110711493A
CN110711493A CN201911033577.1A CN201911033577A CN110711493A CN 110711493 A CN110711493 A CN 110711493A CN 201911033577 A CN201911033577 A CN 201911033577A CN 110711493 A CN110711493 A CN 110711493A
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China
Prior art keywords
membrane
adsorption
filtering
composite
film
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CN201911033577.1A
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Chinese (zh)
Inventor
卢洪洲
徐霞
董强
方邦江
陈怡凝
黄鹤平
张�林
沈烨
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Shanghai Taizi Biotechnology Co Ltd
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Shanghai Taizi Biotechnology Co Ltd
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Priority to CN201911033577.1A priority Critical patent/CN110711493A/en
Publication of CN110711493A publication Critical patent/CN110711493A/en
Priority to CN202011116401.5A priority patent/CN112023706A/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58—Multistep processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0415—Plasma
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/16—Membrane materials having positively charged functional groups

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

The invention provides an adsorption membrane, and a composite membrane component and a filtering device using the adsorption membrane, which are used for adsorbing HIV virus in blood plasma. The material of the adsorption film is lignin mixed with a plurality of positively charged particles, and the positively charged particles are used for adsorbing HIV virus; and, the adsorption film is a porous structure.

Description

Adsorption membrane, composite membrane module and filter
Technical Field
The invention relates to the technical field of blood filtration, in particular to an adsorption membrane, and a composite membrane assembly and a filter using the adsorption membrane.
Background
The prevention and treatment of AIDS is a major research subject related to life health after 21 century. Governments in various countries pay great attention to and support for the prevention and treatment of AIDS, and various medicines and treatment methods for preventing and treating AIDS are continuously appeared.
At present, no report that AIDS virus (HIV) in blood of a patient is directly removed by a filtering method to achieve a treatment effect exists clinically in China. U.S. Pat. No. 6,168,718 discloses a method for reducing HIV in blood by filtration, but the method belongs to ultrafiltration method, and although it has a certain effect in reducing HIV, it also damages normal cells and proteins in human blood.
However, other existing aids virus filtration devices are only suitable for filtration with small dosage, and when a large amount of filtration is required, the filtration membrane cannot be loaded, which results in the situation that filtration cannot be realized.
Therefore, a new HIV filtration device is needed to overcome the above-mentioned shortcomings of the existing gold nanocluster materials.
Disclosure of Invention
The invention aims to provide an adsorption film, a composite film component and a filter using the adsorption film to remove HIV virus in plasma, wherein the adsorption film can specifically adsorb the HIV virus by doping lignin with particles with positive charges, thereby removing the HIV virus.
In order to achieve the above object, the present invention provides an adsorption film for adsorbing HIV virus, wherein the adsorption film is made of lignin doped with a plurality of positively charged particles for adsorbing HIV virus; and, the adsorption film is a porous structure.
In an embodiment of the invention, the thickness of the filtering membrane is 3-5 mm.
In an embodiment of the invention, the pores of the porous structure are 0.1 to 0.6 μm.
In an embodiment of the present invention, the adsorption film comprises positively charged particles, such as but not limited to silicon particles with a positively charged surface, so that the particles are 1+Or 2+. In one embodiment of the invention, the adsorption membrane has specific adsorption for HIV virus.
The invention also provides a composite membrane component for filtering HIV virus in blood plasma, which comprises at least one layer of adsorption membrane and at least one layer of terminal filtration membrane.
In one embodiment of the invention, the composite membrane module comprises at least one first adsorption membrane and at least one second adsorption membrane; wherein the pore diameter of the first adsorption membrane is 0.6 micron, and the pore diameter of the second adsorption membrane is 0.1-0.3 micron.
In a preferred embodiment of the present invention, the composite membrane module includes four layers of the first adsorption membrane, one layer of the second adsorption membrane, and one layer of the end filtration membrane, which are sequentially stacked.
In an embodiment of the invention, the terminal filtering membrane is of a porous structure, the pore diameter is 0.1-0.3 micrometers, and the material of the terminal filtering membrane is polyether sulfone.
The invention also provides a filtering device for filtering HIV virus in blood plasma, which comprises a first shell and a second shell, wherein the first shell and the second shell are mutually clamped to form an accommodating space, and a composite membrane component is arranged in the accommodating space; the composite membrane assembly comprises at least one first adsorption membrane, at least one second adsorption membrane and a terminal filtering membrane which are laminated; wherein the content of the first and second substances,
the composite membrane assembly is formed along the direction of the plasma flow according to the arrangement mode of the first adsorption membrane, the second adsorption membrane and the terminal filtering membrane; and wherein the one or more of the one,
the first adsorption membrane, the second adsorption membrane and the terminal filtering membrane are all of porous structures, the aperture of the first adsorption membrane is 0.6 micrometer, the aperture of the second adsorption membrane is 0.1-0.3 micrometer, the aperture of the terminal filtering membrane is 0.1-0.3 micrometer, the first adsorption membrane and the second adsorption membrane are made of lignin mixed with a plurality of particles with positive charges, and the terminal filtering membrane is made of polyether sulfone.
In an embodiment of the invention, the pressure difference between the first adsorption membrane and the final filtration membrane along the plasma flow direction is 0.3-0.6 kPa.
In the composite membrane module, namely the filtering device, the specific adsorption of HIV virus is realized through the positively charged particles in the adsorption membrane, so that the HIV virus can be adsorbed by the adsorption membrane and retained in the filtering device, and the filtered plasma is returned to a patient.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a composite membrane module according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a filtering apparatus according to an embodiment of the present invention.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
The following disclosure provides many different embodiments or examples for implementing different features of the invention. To simplify the disclosure of the present invention, the components and arrangements of specific examples are described below. Of course, they are merely examples and are not intended to limit the present invention. Furthermore, the present invention may repeat reference numerals and/or letters in the various examples, such repetition is for the purpose of simplicity and clarity and does not in itself dictate a relationship between the various embodiments and/or configurations discussed. In addition, the present invention provides examples of various specific processes and materials, but one of ordinary skill in the art may recognize applications of other processes and/or uses of other materials.
Example 1 adsorption Membrane
In this embodiment, an adsorption membrane for adsorbing HIV virus in plasma is first provided. The material of the adsorption film is lignin mixed with a plurality of positively charged particles, namely, the positively charged particles are uniformly dispersed in the lignin, and the adsorption film with a porous structure is further formed.
In this embodiment, the plurality of positively charged microparticles are used to adsorb the HIV virus, thereby achieving specific adsorption of the HIV virus. The positively charged particles are particles with a positive surface charge, such as but not limited to silicon particles with a positive surface charge, such that the particles are 1+Or 2+。
In the embodiment, the thickness of the filtering membrane is 3-5 mm; the pore of the porous structure is 0.1-0.6 micron.
Example 2. composite Membrane Module 100
In this embodiment, as shown in FIG. 1, a composite membrane module 100 is provided for filtering HIV virus from plasma.
As shown in fig. 1, the composite membrane module 100 may include at least one layer of the adsorption membrane according to example 1 and at least one end filtration membrane.
In the present embodiment, as shown in fig. 1, the composite membrane module 100 includes four layers of the first adsorption membrane 110, one layer of the second adsorption membrane 120, and one layer of the end filtration membrane 130, which are sequentially stacked. The first adsorption membrane 110 is the adsorption membrane described in example 1, and has a pore size of 0.6 μm. The second adsorption film 120 is also the adsorption film described in embodiment 1, and has a pore size of 0.1 to 0.3 μm. In the present embodiment, the bacteria in the plasma can permeate the first adsorption film 110 but cannot pass through the second adsorption film 120, and the HIV viruses are adsorbed by the first adsorption film 110 and the second adsorption film 120.
In this embodiment, the terminal filtering membrane 130 has a porous structure, a pore size of 0.1 to 0.3 μm, and the material of the terminal filtering membrane 130 is polyethersulfone. The final filtering membrane 130 is used for intercepting and separating bacteria and particles thereof in the plasma in a physical blocking way,
EXAMPLE 3 Filter device 200
In this embodiment, as shown in fig. 2, the present invention also provides a filtering device 200 for filtering HIV virus in plasma. The filtering device 200 includes a first housing 211 and a second housing 212, wherein the first housing 211 and the second housing 212 are engaged with each other to form an accommodating space, and a composite membrane module 100 is disposed in the accommodating space. The composite membrane assembly 100 may have the structure of the composite membrane assembly 100 described in example 2. Specifically, the composite membrane assembly 100 includes at least one first adsorption membrane 110, at least one second adsorption membrane 120, and a final filtration membrane 130, which are stacked in the plasma flow direction. In this embodiment, the composite film module 100 described in embodiment 2 will be described as an example. That is, in the filtration apparatus 200 of the present embodiment, the first adsorption membrane 110, the second adsorption membrane 120, and the end filtration membrane 130 are all porous structures, the pore diameter of the first adsorption membrane 110 is 0.6 μm, the pore diameter of the second adsorption membrane 120 is 0.1 to 0.3 μm, and the pore diameter of the end filtration membrane 130 is 0.1 to 0.3 μm. The first adsorption membrane 110 and the second adsorption membrane 120 are made of lignin doped with a plurality of positively charged particles, and the end filtration membrane 130 is made of polyethersulfone.
In this embodiment, the composite membrane module 100 includes four layers of the first adsorption membrane 110, one layer of the second adsorption membrane 120, and one layer of the end filtration membrane 130, which are sequentially stacked, as in example 2.
As shown in fig. 2, the first housing 211 is provided with a plasma inlet 201 and an exhaust port 202, so that plasma can smoothly flow in. As shown in fig. 2, the plasma inlet 201 is located at the center of the first housing 211, which facilitates the smooth and uniform plasma entering the composite membrane assembly 100 after entering the filtering device. The second housing 212 is provided with an outlet 203 for filtered plasma to flow out. Thus, the pressure difference between the first adsorption membrane 110 and the final filtration membrane 130 in the direction along the plasma flow direction (downward in the figure) is set to 0.3 to 0.6 kPa.
It will be understood by those skilled in the art that the first and second housings 211 and 212 may be made of polysulfone or other injection molded materials.
When the composite membrane component is used, blood in a patient body is separated by corpuscles and plasma, the plasma with certain pressure enters the surface layer (namely, the first adsorption layer) of the composite membrane component of the filtering device 200 from the plasma inlet 201 at the top, and the exhaust port 202 can ensure the smooth inflow of the plasma. It will be understood by those skilled in the art that the first housing 211 and the second housing 212 are sealed by a silicone rubber gasket for suction filtration purposes. The pressure difference between the first adsorption membrane 110 and the terminal filtering membrane 130 is 0.3-0.6 kPa, so that the plasma directly leaks downwards through the composite membrane 100 after flowing in through the plasma inlet 201.
The present invention has been described in relation to the above embodiments, which are only exemplary of the implementation of the present invention. It must be noted that the disclosed embodiments do not limit the scope of the invention. Rather, modifications and equivalent arrangements included within the spirit and scope of the claims are included within the scope of the invention.

Claims (9)

1. An adsorption film for adsorbing HIV virus, wherein the adsorption film is made of lignin mixed with a plurality of positively charged particles for adsorbing HIV virus; and, the adsorption film is a porous structure.
2. The adsorption film according to claim 1, wherein the thickness of the adsorption film is 3 to 5 mm.
3. The superabsorbent film of claim 1, wherein the porous structure has pores ranging from 0.1 to 0.6 microns.
4. A composite membrane module for filtering HIV viruses in plasma, comprising at least one adsorption membrane according to claim 1 and at least one terminal filtration membrane.
5. The composite membrane module of claim 4, wherein the composite membrane module comprises at least one first adsorbent membrane and at least one second adsorbent membrane; wherein the pore diameter of the first adsorption membrane is 0.6 micron, and the pore diameter of the second adsorption membrane is 0.1-0.3 micron.
6. The composite membrane module of claim 5, wherein the composite membrane module comprises four layers of the first adsorption membrane, the second adsorption membrane, and the end filtration membrane, which are stacked.
7. The composite membrane module of claim 4, wherein the terminal filtering membrane is a porous structure with a pore size of 0.1-0.3 μm, and the material of the terminal filtering membrane is polyethersulfone.
8. A filtering device is used for filtering HIV virus in blood plasma, and is characterized by comprising a first shell and a second shell, wherein the first shell and the second shell are mutually clamped to form an accommodating space, and a composite membrane assembly is arranged in the accommodating space; the composite membrane assembly comprises at least one first adsorption membrane, at least one second adsorption membrane and a terminal filtering membrane which are laminated; wherein the content of the first and second substances,
the composite membrane assembly is formed along the direction of the plasma flow according to the arrangement mode of the first adsorption membrane, the second adsorption membrane and the terminal filtering membrane; and wherein the one or more of the one,
the first adsorption membrane, the second adsorption membrane and the terminal filtering membrane are all of porous structures, the aperture of the first adsorption membrane is 0.6 micrometer, the aperture of the second adsorption membrane is 0.1-0.3 micrometer, the aperture of the terminal filtering membrane is 0.1-0.3 micrometer, the first adsorption membrane and the second adsorption membrane are made of lignin mixed with a plurality of particles with positive charges, and the terminal filtering membrane is made of polyether sulfone.
9. The filtration device according to claim 8, wherein the pressure difference between the first adsorption membrane and the final filtration membrane is 0.3 to 0.6kPa in the plasma flow direction.
CN201911033577.1A 2019-10-28 2019-10-28 Adsorption membrane, composite membrane module and filter Pending CN110711493A (en)

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN112619596A (en) * 2020-12-01 2021-04-09 上海江夏血液技术有限公司 Adsorption membrane and preparation method thereof, composite membrane component and filter

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CN113209936A (en) * 2021-04-13 2021-08-06 上海泰滋生物科技有限公司 Preparation method of adsorption membrane material for adsorbing HIV (human immunodeficiency virus) and adsorption membrane

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US20070031512A1 (en) * 2005-08-03 2007-02-08 Amcol International Corporation Virus-interacting layered phyllosilicates and methods of inactivating viruses
CN201098399Y (en) * 2007-10-16 2008-08-13 上海达华医疗器械有限公司 Filtering film for multifunctional blood plasma therapeutic equipment
CN106540344A (en) * 2016-12-23 2017-03-29 上海江夏血液技术有限公司 For treating the plasma filtering device and method of acute cerebral infarction
CN107213806B (en) * 2017-07-13 2018-03-06 广州达济医学科技有限公司 A kind of filter membrane for filtrating leukocytes and preparation method thereof
CN110152496B (en) * 2018-01-30 2021-10-15 广州达济医学科技有限公司 Leukocyte filtering membrane and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112619596A (en) * 2020-12-01 2021-04-09 上海江夏血液技术有限公司 Adsorption membrane and preparation method thereof, composite membrane component and filter

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Application publication date: 20200121