CN110692888A - Cola beverage containing water-soluble cannabidiol and preparation method thereof - Google Patents
Cola beverage containing water-soluble cannabidiol and preparation method thereof Download PDFInfo
- Publication number
- CN110692888A CN110692888A CN201911203045.8A CN201911203045A CN110692888A CN 110692888 A CN110692888 A CN 110692888A CN 201911203045 A CN201911203045 A CN 201911203045A CN 110692888 A CN110692888 A CN 110692888A
- Authority
- CN
- China
- Prior art keywords
- water
- cyclodextrin
- cannabidiol
- cola
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 title claims abstract description 82
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 title claims abstract description 82
- 229950011318 cannabidiol Drugs 0.000 title claims abstract description 82
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 title claims abstract description 82
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 title claims abstract description 81
- 235000013361 beverage Nutrition 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 40
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 33
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims abstract description 26
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 24
- FYGDTMLNYKFZSV-DZOUCCHMSA-N alpha-D-Glcp-(1->4)-alpha-D-Glcp-(1->4)-D-Glcp Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O[C@@H]2[C@H](OC(O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-DZOUCCHMSA-N 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 14
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960001948 caffeine Drugs 0.000 claims abstract description 13
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims abstract description 12
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000013736 caramel Nutrition 0.000 claims abstract description 11
- 239000000049 pigment Substances 0.000 claims abstract description 11
- 239000003755 preservative agent Substances 0.000 claims abstract description 6
- 230000002335 preservative effect Effects 0.000 claims abstract description 6
- 230000008569 process Effects 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 238000003756 stirring Methods 0.000 claims description 26
- 229920000858 Cyclodextrin Polymers 0.000 claims description 22
- 238000001914 filtration Methods 0.000 claims description 15
- 230000001954 sterilising effect Effects 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 13
- 238000004659 sterilization and disinfection Methods 0.000 claims description 10
- 239000006188 syrup Substances 0.000 claims description 10
- 235000020357 syrup Nutrition 0.000 claims description 10
- 238000001291 vacuum drying Methods 0.000 claims description 9
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims description 7
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims description 7
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 239000001116 FEMA 4028 Substances 0.000 claims description 6
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 6
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 6
- 229960004853 betadex Drugs 0.000 claims description 6
- -1 methyl cyclodextrin Chemical compound 0.000 claims description 6
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 6
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 6
- JYYOBHFYCIDXHH-UHFFFAOYSA-N carbonic acid;hydrate Chemical compound O.OC(O)=O JYYOBHFYCIDXHH-UHFFFAOYSA-N 0.000 claims description 5
- 238000007872 degassing Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 238000011049 filling Methods 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 5
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 4
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 4
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims description 4
- 239000004302 potassium sorbate Substances 0.000 claims description 4
- 235000010241 potassium sorbate Nutrition 0.000 claims description 4
- 229940069338 potassium sorbate Drugs 0.000 claims description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
- 239000004299 sodium benzoate Substances 0.000 claims description 4
- 235000010234 sodium benzoate Nutrition 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 238000004090 dissolution Methods 0.000 claims description 3
- PCWPQSDFNIFUPO-VDQKLNDWSA-N (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37S,38R,39S,40R,41S,42R,43S,44R,45S,46R,47S,48R,49S)-37,39,41,43,45,47,49-heptakis(2-hydroxyethoxy)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,38,40,42,44,46,48-heptol Chemical compound OCCO[C@H]1[C@H](O)[C@@H]2O[C@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@H](CO)[C@@H](O[C@H]5O[C@H](CO)[C@@H](O[C@H]6O[C@H](CO)[C@@H](O[C@H]7O[C@H](CO)[C@@H](O[C@H]8O[C@H](CO)[C@@H](O[C@H]1O[C@@H]2CO)[C@@H](O)[C@@H]8OCCO)[C@@H](O)[C@@H]7OCCO)[C@@H](O)[C@@H]6OCCO)[C@@H](O)[C@@H]5OCCO)[C@@H](O)[C@@H]4OCCO)[C@@H](O)[C@@H]3OCCO PCWPQSDFNIFUPO-VDQKLNDWSA-N 0.000 claims description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 2
- 238000000265 homogenisation Methods 0.000 claims description 2
- 229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 12
- 239000004480 active ingredient Substances 0.000 abstract description 5
- 230000036541 health Effects 0.000 abstract description 5
- 230000003796 beauty Effects 0.000 abstract description 3
- 239000002244 precipitate Substances 0.000 abstract description 3
- 238000004321 preservation Methods 0.000 abstract description 3
- 230000001766 physiological effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 14
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 9
- 239000007787 solid Substances 0.000 description 9
- 150000003254 radicals Chemical class 0.000 description 8
- 238000002835 absorbance Methods 0.000 description 7
- 230000003078 antioxidant effect Effects 0.000 description 7
- 235000019441 ethanol Nutrition 0.000 description 7
- 238000001816 cooling Methods 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 239000003963 antioxidant agent Substances 0.000 description 5
- 230000002000 scavenging effect Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 239000012043 crude product Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 238000005360 mashing Methods 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 3
- 239000004300 potassium benzoate Substances 0.000 description 3
- 235000010235 potassium benzoate Nutrition 0.000 description 3
- 229940103091 potassium benzoate Drugs 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 230000007480 spreading Effects 0.000 description 3
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- 238000012360 testing method Methods 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 208000019901 Anxiety disease Diseases 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010067171 Regurgitation Diseases 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
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- 230000001105 regulatory effect Effects 0.000 description 2
- 230000009758 senescence Effects 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010053510 Venomous sting Diseases 0.000 description 1
- 241000234314 Zingiber Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229930003827 cannabinoid Natural products 0.000 description 1
- 239000003557 cannabinoid Substances 0.000 description 1
- 229940065144 cannabinoids Drugs 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 240000004308 marijuana Species 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 231100001096 no neurotoxicity Toxicity 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Non-Alcoholic Beverages (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a cola beverage containing water-soluble cannabidiol and a preparation method thereof, wherein the beverage comprises the following components: 1-10 parts of water-soluble cannabidiol, 0.5-2 parts of caffeine, 5-10 parts of malto-oligosaccharide, 0.1-1 part of citric acid, 0.1-0.3 part of phosphoric acid, 0.1-0.2 part of cola essence, 0.05-0.2 part of caramel pigment, 0.01-0.05 part of preservative and 100 parts of carbonated water. Cannabidiol (CBD) has a number of physiological effects: for example, the CBD is insoluble in water, so that the application field and the bioavailability of the CBD are limited, the water solubility and the bioavailability of the cannabidiol are greatly improved through a special process on the premise of not changing the molecular structure of the CBD, so that the cola beverage taking the cannabidiol as an active ingredient is clear and transparent in appearance, free of precipitate and obvious in health-care effect, and is a health-care beverage integrating leisure, health preservation and beauty.
Description
Technical Field
The invention belongs to the technical field of beverage processing, and particularly relates to a cola beverage containing water-soluble cannabidiol and a preparation method thereof.
Background
The cola is one of the most extensive beverages of consumer groups, has fresh and stimulating mouthfeel, and is deeply loved by the consumers. Besides a pleasant taste, the cola beverage also has a plurality of practical effects. The cola ginger decoction can be used as adjuvant therapy for relieving common cold; the cola contains caffeine, according to western medicine, the caffeine has obvious excitation effect on the central nervous system of human, and can promote blood circulation, expand blood vessels and promote cerebral blood circulation; the cola has strong analgesic effect on jellyfish sting; the regurgitation is relieved, and the drinking of a cup of cola slowly is greatly helpful for relieving the regurgitation; if symptoms of diarrhea and sore throat occur, the cola also has good curative effect; dissolving calculus, wherein the cola contains phosphoric acid and carbon dioxide, and has certain curative effect on plant calculus; the cola beverage not only can quench thirst, but also can make people feel comfortable and pleasant.
Cannabidiol (CBD) is extracted from industrial cannabis, and has not been isolated from other animals and plants. Cannabidiol is a main active ingredient in cannabinoids, is a non-addictive active ingredient, has no neurotoxicity, and researches show that cannabidiol has a series of physiological active functions of blocking breast cancer metastasis, resisting epilepsy, resisting spasm, resisting rheumatoid arthritis, resisting anxiety, resisting insomnia and the like. In recent years, scientists also find that cannabidiol is a powerful antioxidant, can effectively remove free radicals in a human body, and has the effects of resisting inflammation, resisting oxidation, delaying senescence and repairing damaged cells. However, cannabidiol is a fat-soluble compound and is insoluble in water, so that the application field of cannabidiol is limited, the bioavailability of cannabidiol is reduced when the cannabidiol is directly used, and the effect of cannabidiol cannot be fully exerted. Therefore, the improvement of the water solubility of the cannabidiol is a crucial link for developing cannabidiol related end products.
At present, no report is found about cola beverage prepared by using water-soluble cannabidiol as an active ingredient.
Disclosure of Invention
In order to solve the problems, the invention provides a cola beverage containing water-soluble cannabidiol and a preparation method thereof.
The purpose of the invention is realized by the following technical scheme:
1. a cola beverage containing water-soluble cannabidiol and a preparation method thereof are characterized by comprising the following components in parts by weight:
1-10 parts of water-soluble cannabidiol;
5-10 parts of malto-oligosaccharide;
0.5-2 parts of caffeine;
0.1-1 part of citric acid;
0.1-0.3 part of phosphoric acid;
0.1-0.2 part of cola essence;
0.05-0.2 part of caramel pigment;
0.01-0.05 part of preservative;
and (5) carbonic acid water to 100 parts.
2. A cola beverage containing water soluble cannabidiol and its preparation method comprises the following steps:
s1, mixing the malto-oligosaccharide and carbonated water according to the proportion of 1:4, heating to boil, stirring until the malto-oligosaccharide is completely dissolved, sequentially adding citric acid and phosphoric acid, stirring uniformly, and filtering when the mixture is hot to obtain syrup.
S2, cooling the syrup to 50-60 deg.C, sequentially adding water soluble cannabidiol, caffeine, cola essence, caramel pigment and antiseptic, dissolving completely, and stirring to obtain cola.
S3, homogenizing the blended cola for 2 times at 40-50 ℃ and 15-20MPa, and then carrying out cold sterilization, namely filtering and sterilizing by using a 0.22 mu m microporous filter membrane.
S4, degassing the cola after filtration and sterilization for 10-15min under the vacuum degree of 0.08 MPa.
S5, filling and sealing the degassed cola to obtain the cola beverage containing the water-soluble cannabidiol.
3. A preparation method of water-soluble cannabidiol comprises the following steps of ① dissolving high-purity CBD crystals with 2-5 times of ethanol to form a solution, ② heating and dissolving cyclodextrin with 1-5 times of pure water or ethanol-water, adding ① the solution after complete dissolution, stirring and mixing uniformly, ③ clathrating, mixing uniformly the solution formed by ① and ②, carrying out cannabidiol clathration by using a high-pressure homogenization method, carrying out reduced-pressure concentration by using a rotary evaporator after the completion of the cannabidiol clathration, removing most of solvent and water, ④ drying, and carrying out vacuum drying on the material obtained by ③ to obtain the cannabidiol clathrate (water-soluble).
The preservative comprises at least one of sodium benzoate, potassium benzoate and potassium sorbate; the cyclodextrin comprises alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, hydroxypropyl-beta-cyclodextrin, hydroxyethyl-beta-cyclodextrin, methyl cyclodextrin, hydroxypropyl cyclodextrin, carboxymethyl cyclodextrin and sulfobutyl ether-beta-cyclodextrin; preferred are alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, and hydroxypropyl-beta-cyclodextrin.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the invention, the water-insoluble cannabidiol is embedded with high-purity CBD by a cyclodextrin inclusion method on the premise of not changing the molecular structure, so that the water solubility, the stability and the bioavailability of the CBD are greatly improved, and the effect of the CBD is fully exerted.
2. The cola beverage disclosed by the invention takes cannabidiol as an active ingredient, is clear and transparent in appearance, free of precipitate, comfortable and refreshing in taste, and obvious in health care effect, has the effects of resisting inflammation, resisting oxidation, delaying senescence, resisting anxiety, resisting insomnia, regulating immunity and the like, and is a health care beverage integrating leisure, health preservation and beauty.
Detailed Description
The following examples are merely illustrative of the present invention and do not limit the scope of the present invention in any way. For process parameters or conditions not specifically mentioned, it can be carried out with reference to conventional techniques. It will be apparent to those skilled in the art that equivalent embodiments or modifications without departing from the technical spirit of the present invention are within the scope of the present invention.
Example 1
1. The preparation of water-soluble cannabidiol comprises the following steps:
① accurately weighing 100g cannabidiol solid powder and 500g ethanol, adding into 1L round bottom flask, mechanically stirring for 30min to dissolve cannabidiol solid completely, and cooling to room temperature.
② adding 300g of alpha-cyclodextrin and 900g of first-class purified water into a 2L single-neck round-bottom flask, placing the flask in a 40 ℃ water bath, mechanically stirring for 30min to fully dissolve the alpha-cyclodextrin in the water to form a transparent solution, adding the solution obtained in the step ① into the solution once after the alpha-cyclodextrin is completely dissolved, and continuously stirring for 10 min.
③ clathrating, placing the mixed solution prepared in step ② into a high pressure homogenizer, starting the high pressure pump, homogenizing for 3 times at 25 deg.C under 35MPa, concentrating under reduced pressure with a rotary evaporator to remove ethanol and water, and vacuum degree of-0.1 MPa at 70 deg.C.
④ drying, vacuum concentrating to obtain crude product, mashing solid block into powder, spreading in a watch glass, vacuum drying in a vacuum drying oven at 35 deg.C under-0.08 MPa for 72 hr to obtain cannabidiol clathrate (water soluble).
2. A cola beverage containing water-soluble cannabidiol and a preparation method thereof, which comprises the following components by weight:
1 part of water-soluble cannabidiol;
5 parts of oligomeric maltose
0.5 part of caffeine;
0.1 part of citric acid;
0.1 part of phosphoric acid;
0.1 part of cola essence;
0.05 part of caramel pigment;
0.01 part of sodium benzoate;
and (5) carbonic acid water to 100 parts.
3. A cola beverage containing water soluble cannabidiol and its preparation method comprises the following steps:
s1, mixing the malto-oligosaccharide and carbonated water according to the proportion of 1:4, heating to boil, stirring until the malto-oligosaccharide is completely dissolved, sequentially adding citric acid and phosphoric acid, stirring uniformly, and filtering when the mixture is hot to obtain syrup.
S2, cooling the syrup to 50 deg.C, sequentially adding water soluble cannabidiol, caffeine, cola essence, caramel pigment, and sodium benzoate, dissolving completely, and stirring to obtain cola.
S3, homogenizing the blended cola for 2 times at 40 ℃ and 15MPa, and then carrying out cold sterilization, namely filtering and sterilizing by using a 0.22-micron microporous filter membrane.
S4, degassing the cola after filtration and sterilization for 10min under the vacuum degree of 0.08 MPa.
S5, filling and sealing the degassed cola to obtain the cola beverage containing the water-soluble cannabidiol.
Example 2
1. The preparation of water-soluble cannabidiol comprises the following steps:
① accurately weighing 100g cannabidiol solid powder and 500g ethanol, adding into 1L round bottom flask, mechanically stirring for 30min to dissolve cannabidiol solid completely, and cooling to room temperature.
② adding 300g beta-cyclodextrin and 900g first-class purified water into 2L round-bottom flask, placing the flask in 40 deg.C water bath, mechanically stirring for 30min to dissolve beta-cyclodextrin in water to form transparent solution, adding ① solution once after dissolving completely, and stirring for 10 min.
③ clathrating, placing the mixed solution prepared in step ② into a high pressure homogenizer, starting the high pressure pump, homogenizing for 3 times at 25 deg.C under 30MPa, concentrating under reduced pressure with a rotary evaporator to remove ethanol and water, and vacuum degree of-0.1 MPa at 70 deg.C.
④ drying, vacuum concentrating to obtain crude product, mashing solid block into powder, spreading in a watch glass, vacuum drying in a vacuum drying oven at 35 deg.C under-0.08 MPa for 72 hr to obtain cannabidiol clathrate (water soluble).
2. A cola beverage containing water-soluble cannabidiol and a preparation method thereof, which comprises the following components by weight:
5 parts of water-soluble cannabidiol;
7 parts of malto-oligosaccharide;
1 part of caffeine;
0.5 part of citric acid;
0.2 part of phosphoric acid;
0.15 part of cola essence;
0.1 part of caramel pigment;
0.02 part of potassium benzoate;
and (5) carbonic acid water to 100 parts.
3. A method for preparing a cola beverage comprising water soluble cannabidiol, comprising the steps of:
s1, mixing the malto-oligosaccharide and carbonated water according to the proportion of 1:4, heating to boil, stirring until the malto-oligosaccharide is completely dissolved, sequentially adding citric acid and phosphoric acid, stirring uniformly, and filtering when the mixture is hot to obtain syrup.
S2, when the temperature of the syrup is reduced to 60 ℃, adding water-soluble cannabidiol, caffeine, cola essence, caramel pigment and potassium benzoate in sequence, fully dissolving, and stirring uniformly to obtain cola.
S3, homogenizing the blended cola for 2 times at 50 ℃ and 15MPa, and then carrying out cold sterilization, namely filtering and sterilizing by using a 0.22-micron microporous filter membrane.
S4, degassing the cola after filtration and sterilization for 15min under the vacuum degree of 0.08 MPa.
S5, filling and sealing the degassed cola to obtain the cola beverage containing the water-soluble cannabidiol.
Example 3
1. The preparation of water-soluble cannabidiol comprises the following steps:
① accurately weighing 100g cannabidiol solid powder and 500g ethanol, adding into 1L round bottom flask, mechanically stirring for 30min to dissolve cannabidiol solid completely, and cooling to room temperature.
② adding 200g hydroxypropyl beta-cyclodextrin and 900g first-class purified water into a 2L single-neck round-bottom flask, placing the flask in a 40 ℃ water bath, mechanically stirring for 30min to fully dissolve hydroxypropyl beta-cyclodextrin in water to form a transparent solution, adding the solution obtained in step ① once after complete dissolution, and continuing stirring for 10 min.
③ clathrating, placing the mixed solution prepared in step ② into a high pressure homogenizer, starting the high pressure pump, homogenizing for 3 times at 25 deg.C under 40MPa, concentrating under reduced pressure with a rotary evaporator to remove ethanol and water, and vacuum degree of-0.1 MPa at 70 deg.C.
④ drying, vacuum concentrating to obtain crude product, mashing solid block into powder, spreading in a watch glass, vacuum drying in a vacuum drying oven at 35 deg.C under-0.08 MPa for 72 hr to obtain cannabidiol clathrate (water soluble).
2. A cola beverage containing water-soluble cannabidiol and a preparation method thereof, which comprises the following components by weight:
10 parts of water-soluble cannabidiol;
10 parts of malto-oligosaccharide;
2 parts of caffeine;
1 part of citric acid;
0.3 part of phosphoric acid;
0.2 part of cola essence;
0.2 part of caramel pigment;
0.05 part of potassium sorbate;
and (5) carbonic acid water to 100 parts.
3. A cola beverage containing water soluble cannabidiol and its preparation method comprises the following steps:
s1, mixing the malto-oligosaccharide and carbonated water according to the proportion of 1:4, heating to boil, stirring until the malto-oligosaccharide is completely dissolved, sequentially adding citric acid and phosphoric acid, stirring uniformly, and filtering when the mixture is hot to obtain syrup.
S2, cooling the syrup to 55 deg.C, sequentially adding water soluble cannabidiol, caffeine, cola essence, caramel pigment, and potassium sorbate, dissolving, and stirring to obtain cola.
S3, homogenizing the blended cola for 2 times at 45 ℃ and 15MPa, and then carrying out cold sterilization, namely filtering and sterilizing by using a 0.22-micron microporous filter membrane.
S4, degassing the cola after filtration and sterilization for 10min under the vacuum degree of 0.08 MPa.
S5, filling and sealing the degassed cola to obtain the cola beverage containing the water-soluble cannabidiol.
Test examples
Determination of antioxidant Activity
The effect of the cola beverage on scavenging free radicals is tested through an in vitro antioxidant test, so that the antioxidant capacity of the cola beverage is verified.
DPPH is a stable free radical, and when a free radical scavenger is added to a DPPH solution, the solution becomes lighter in color, the absorbance at 517nm decreases, and the degree of decrease in absorbance is linear with the degree to which the free radical is scavenged. Therefore, the method can be used for detecting the scavenging condition of free radicals so as to evaluate the antioxidant capacity of a certain substance, and the capacity is expressed by the Scavenging Rate (SR), and the larger the scavenging rate is, the stronger the antioxidant capacity is.
Test materials: examples 1 to 3, a commercial control.
The experimental method comprises the following steps: dissolving 1mL of cola beverage in 2mL of absolute ethanol, completely mixing, adding 2mL of 60 mu mol/L DPPH solution, mixing, standing for 30min, adjusting to zero with absolute ethanol, and measuring absorbance at 517nm to be Ai; in the same method, 2mL of absolute ethyl alcohol solvent and 2mL of DPPH solution are uniformly mixed, and the absorbance is measured to be Ac; dissolving 1mL of cola beverage in 2mL of absolute ethyl alcohol, mixing uniformly, adding 2mL of absolute ethyl alcohol solvent, mixing uniformly, and determining the absorbance Aj. The radical scavenging rate was calculated by the following formula.
The clearance (%) [1- (Ai-Aj)/Ac ] x 100%
Wherein Aj reflects the contribution of the sample itself to absorbance; absorbance values of Ai samples after action on DPPH; ac is the absorption of DPPH itself at the measurement wavelength.
The results of the experiment are shown in table 1:
TABLE 1 free radical (DPPH) scavenging effect of cola beverages of the invention
| Sample (I) | Clearance (%) |
| Example 1 | 89.7 |
| Example 2 | 91.9 |
| Example 3 | 93.6 |
| Commercial control | 68.7 |
The results in Table 1 show that the clearance of free radical DPPH in examples 1-3 is significantly higher than that of the commercial reference, which indicates that the water-soluble cannabidiol has better clearance of free radical DPPH, and indicates that the cola beverage of the present invention has better antioxidant effect and can delay aging.
The cola beverage is light brownish red, clear and transparent, free of precipitate, proper in sweetness and sourness, has the specific smell of cola, is a health-care beverage, has the effects of resisting oxidation, inflammation and insomnia, regulating immunity and the like, and is a beverage which integrates leisure, health preservation and beauty treatment and is suitable for people of all ages.
The above examples are merely illustrative of the present invention and do not limit the scope of the present invention in any way. For process parameters or conditions not specifically mentioned, it can be carried out with reference to conventional techniques. It will be apparent to those skilled in the art that equivalent embodiments or modifications without departing from the technical spirit of the present invention are within the scope of the present invention.
Claims (8)
1. A cola beverage containing water-soluble cannabidiol and a preparation method thereof are characterized by comprising the following components in parts by weight:
1-10 parts of water-soluble cannabidiol;
5-10 parts of oligomeric maltose
0.5-2 parts of caffeine;
0.1-1 part of citric acid;
0.1-0.3 part of phosphoric acid;
0.1-0.2 part of cola essence;
0.05-0.2 part of caramel pigment;
0.01-0.05 part of preservative;
and (5) carbonic acid water to 100 parts.
2. A cola beverage containing water soluble cannabidiol as claimed in claim 1 and process for its preparation comprising the steps of:
s1, mixing the malto-oligosaccharide and carbonated water according to the ratio of 1:4, heating to boil, stirring until the malto-oligosaccharide is completely dissolved, sequentially adding citric acid and phosphoric acid, stirring uniformly, and filtering while hot to obtain syrup;
s2, when the temperature of the syrup is reduced to 50-60 ℃, sequentially adding water-soluble cannabidiol, caffeine, cola essence, caramel pigment and preservative, fully dissolving, and uniformly stirring to obtain cola;
s3, homogenizing the blended cola for 2 times at 40-50 ℃ and 15-20MPa, and then carrying out cold sterilization, namely filtering and sterilizing by using a 0.22 mu m microporous filter membrane;
s4, degassing the cola after filtration and sterilization for 10-15min under the vacuum degree of 0.08 MPa;
s5, filling and sealing the degassed cola to obtain the cola beverage containing the water-soluble cannabidiol.
3. The cola beverage containing water-soluble cannabidiol as claimed in claim 1 or 2, wherein the preparation method of water-soluble cannabidiol comprises ① dissolving high-purity CBD crystals with 2-5 times of ethanol to form a solution, ② heating cyclodextrin with 1-5 times of pure water or ethanol-water to dissolve it completely, ① adding the solution into it, stirring and mixing uniformly, ③ clathrating, ①, ② mixing uniformly, performing cannabidiol clathration by high pressure homogenization, concentrating under reduced pressure by a rotary evaporator to remove most of solvent and water, ④ drying, and vacuum drying ③ to obtain the cannabidiol clathrate (water-soluble cannabidiol).
4. A cola beverage containing water soluble cannabidiol as claimed in claims 1 to 3 and method of preparation thereof wherein the preservative comprises at least one of sodium benzoate, potassium sorbate; the cyclodextrin comprises alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, hydroxypropyl-beta-cyclodextrin, hydroxyethyl-beta-cyclodextrin, methyl cyclodextrin, hydroxypropyl cyclodextrin, carboxymethyl cyclodextrin and sulfobutyl ether-beta-cyclodextrin; preferred are alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, and hydroxypropyl-beta-cyclodextrin.
5. The method of claim 3, wherein the cannabidiol has a purity of greater than 99%.
6. The method of claim 3, wherein the amount of pure water used in step ② is 1-5 times the mass of cyclodextrin, and the temperature of heated dissolution is 30-60 ℃.
7. The method of claim 3, wherein the homogenizing step ③ is performed at a pressure of 30-50MPa and a temperature of 25 ℃ for 2-3 times.
8. The method of claim 3, wherein the step ④ is performed by vacuum drying in a vacuum oven at a vacuum degree of-0.08 MPa for 60-120h at 30-60 ℃.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112715810A (en) * | 2021-01-19 | 2021-04-30 | 云南绿新生物药业有限公司 | Apple vinegar beverage containing water-soluble cannabidiol and preparation method thereof |
| CN112970982A (en) * | 2021-03-01 | 2021-06-18 | 云南绿新生物药业有限公司 | Solid functional beverage containing water-soluble cannabidiol and preparation method thereof |
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2019
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112715810A (en) * | 2021-01-19 | 2021-04-30 | 云南绿新生物药业有限公司 | Apple vinegar beverage containing water-soluble cannabidiol and preparation method thereof |
| CN112970982A (en) * | 2021-03-01 | 2021-06-18 | 云南绿新生物药业有限公司 | Solid functional beverage containing water-soluble cannabidiol and preparation method thereof |
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