CN110678184A - 用于治疗乙酰胆碱依赖性疾病的acefapc - Google Patents
用于治疗乙酰胆碱依赖性疾病的acefapc Download PDFInfo
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- CN110678184A CN110678184A CN201880016533.5A CN201880016533A CN110678184A CN 110678184 A CN110678184 A CN 110678184A CN 201880016533 A CN201880016533 A CN 201880016533A CN 110678184 A CN110678184 A CN 110678184A
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- Prior art keywords
- acefapc
- formula
- acyl group
- fatty acid
- acetylcholine
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- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 title claims abstract description 44
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- 238000011282 treatment Methods 0.000 title claims abstract description 17
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- 125000002252 acyl group Chemical group 0.000 claims abstract description 28
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- 239000000203 mixture Substances 0.000 claims description 33
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- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 8
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 8
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- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 8
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 8
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 8
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- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 description 3
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- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 description 3
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 3
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
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- GWHCXVQVJPWHRF-KTKRTIGZSA-N (15Z)-tetracosenoic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCCCC(O)=O GWHCXVQVJPWHRF-KTKRTIGZSA-N 0.000 description 1
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 description 1
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- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 description 1
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- 206010051290 Central nervous system lesion Diseases 0.000 description 1
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- SECPZKHBENQXJG-UHFFFAOYSA-N cis-palmitoleic acid Natural products CCCCCCC=CCCCCCCCC(O)=O SECPZKHBENQXJG-UHFFFAOYSA-N 0.000 description 1
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- 208000028867 ischemia Diseases 0.000 description 1
- 125000002669 linoleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
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- QAPAPLIQQTVEJZ-UHFFFAOYSA-N n-[(3-fluorophenyl)methyl]ethanamine Chemical compound CCNCC1=CC=CC(F)=C1 QAPAPLIQQTVEJZ-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1751880 | 2017-03-08 | ||
| FR1751880A FR3063645B1 (fr) | 2017-03-08 | 2017-03-08 | Acefapc pour le traitement des maladies acetylcholine dependantes |
| PCT/EP2018/055706 WO2018162617A1 (fr) | 2017-03-08 | 2018-03-08 | AceFaPC POUR LE TRAITEMENT DES MALADIES ACÉTYLCHOLINE DÉPENDANTES |
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| CN110678184A true CN110678184A (zh) | 2020-01-10 |
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| EP (1) | EP3592360B1 (es) |
| CN (1) | CN110678184A (es) |
| CA (1) | CA3055464A1 (es) |
| ES (1) | ES2923149T3 (es) |
| FR (1) | FR3063645B1 (es) |
| WO (1) | WO2018162617A1 (es) |
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|---|---|---|---|---|
| KR20220082117A (ko) | 2019-02-21 | 2022-06-16 | 위니베르시테 끌로드 베르나르 리옹 Ⅰ | 항-염증 화합물에 대한 구조화된 분자 벡터 및 이의 용도 |
| WO2020254675A1 (en) | 2019-06-20 | 2020-12-24 | Aker Biomarine Antarctic As | Parenteral lysophosphatidylcholine formulations such as lpc-dha, lpc-epa and their use in therapy |
| NL2023407B1 (en) | 2019-06-28 | 2021-02-01 | Aker Biomarine Antarctic As | Parenteral lysophosphatidylcholine formulations |
| KR20230004545A (ko) | 2020-03-31 | 2023-01-06 | 에이커 바이오마린 앤탁틱 에이에스 | Lpc-dha 및 lpc-epa가 풍부한 크릴 오일 조성물 |
| WO2022101678A2 (en) | 2020-11-15 | 2022-05-19 | Aker Biomarine Antarctic As | Lysophospholipid formulations |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017006047A1 (fr) * | 2015-07-06 | 2017-01-12 | Institut National Des Sciences Appliquees De Lyon | 1-acetyl,2-acylglycerophosphocholines, pour le traitement d'une inflammation ou d'un cancer intestinal |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008068413A2 (fr) | 2006-11-14 | 2008-06-12 | INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON (INSA de Lyon) | Procede de preparation d'acetyl, docosahexaenoyl-glycérophosphocholine, et son utilisation pour l'apport d'acides gras polyinsatures |
| FR2979825B1 (fr) * | 2011-09-13 | 2013-11-29 | Inst Nat Sciences Appliq | Phosphatidylcholines specifiques en tant que modulateurs de l'activite du facteur d'activation plaquettaire |
-
2017
- 2017-03-08 FR FR1751880A patent/FR3063645B1/fr active Active
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2018
- 2018-03-08 CA CA3055464A patent/CA3055464A1/en active Pending
- 2018-03-08 WO PCT/EP2018/055706 patent/WO2018162617A1/fr unknown
- 2018-03-08 CN CN201880016533.5A patent/CN110678184A/zh active Pending
- 2018-03-08 US US16/491,492 patent/US20200054653A1/en not_active Abandoned
- 2018-03-08 EP EP18709010.5A patent/EP3592360B1/fr active Active
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017006047A1 (fr) * | 2015-07-06 | 2017-01-12 | Institut National Des Sciences Appliquees De Lyon | 1-acetyl,2-acylglycerophosphocholines, pour le traitement d'une inflammation ou d'un cancer intestinal |
Non-Patent Citations (1)
| Title |
|---|
| HACHEM MAYSSA等: "Efficient docosahexaenoic acid uptake by the brain from a structured phospholipid", 《MOLECULAR NEUROBIOLOGY》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR3063645B1 (fr) | 2021-06-11 |
| US20220273682A1 (en) | 2022-09-01 |
| EP3592360B1 (fr) | 2022-04-20 |
| CA3055464A1 (en) | 2018-09-13 |
| WO2018162617A1 (fr) | 2018-09-13 |
| ES2923149T3 (es) | 2022-09-23 |
| US20200054653A1 (en) | 2020-02-20 |
| EP3592360A1 (fr) | 2020-01-15 |
| FR3063645A1 (fr) | 2018-09-14 |
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