CN110665118A - Remote monitoring and control pulse electric stimulation flexible electronic chitosan application - Google Patents

Remote monitoring and control pulse electric stimulation flexible electronic chitosan application Download PDF

Info

Publication number
CN110665118A
CN110665118A CN201910864125.1A CN201910864125A CN110665118A CN 110665118 A CN110665118 A CN 110665118A CN 201910864125 A CN201910864125 A CN 201910864125A CN 110665118 A CN110665118 A CN 110665118A
Authority
CN
China
Prior art keywords
electrical stimulation
chitosan
flexible electronic
pulse
wound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910864125.1A
Other languages
Chinese (zh)
Inventor
谈伟强
王晓凤
汪正财
汪小知
马菁晶
蔡佳沁
李华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang University ZJU
Original Assignee
Zhejiang University ZJU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang University ZJU filed Critical Zhejiang University ZJU
Priority to CN201910864125.1A priority Critical patent/CN110665118A/en
Publication of CN110665118A publication Critical patent/CN110665118A/en
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0468—Specially adapted for promoting wound healing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0492—Patch electrodes
    • A61N1/0496—Patch electrodes characterised by using specific chemical compositions, e.g. hydrogel compositions, adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3553—Range remote, e.g. between patient's home and doctor's office

Abstract

The invention provides a pulse electrical stimulation flexible electronic chitosan application for remote monitoring and control, which consists of a terminal and the pulse electrical stimulation flexible electronic chitosan application, wherein the terminal comprises an application program of the pulse electrical stimulation flexible electronic chitosan application and a terminal communication device. The pulse electrical stimulation flexible electronic chitosan application comprises a wireless communication device, a back lining layer, a pulse electrical stimulation device, a protective film, an early warning device, a medicine cushion layer, a wound environment monitoring sensor and release paper. The invention can monitor and obtain the wound information of the patient in real time and adjust the application parameters in time, and can also guide the patient or family members to adjust the treatment scheme in real time. The device has small volume, is convenient to carry, has a remote control function, and thus can be used for treating patients in a personalized and multidirectional way, and brings great convenience to the life of the patients. The invention efficiently and conveniently improves the advice of the chronic wound patients and really realizes the effective treatment of long-term regularity.

Description

Remote monitoring and control pulse electric stimulation flexible electronic chitosan application
Technical Field
The invention belongs to medical application, and particularly relates to a remote monitoring and control pulse electrical stimulation flexible electronic chitosan application.
Background
Chronic difficult-to-heal wounds of diabetes mellitus are a big problem faced by the global health care system. The chronic wound of diabetes has the characteristics of long course of disease, susceptibility to infection, more complications, high treatment cost and the like, and needs long-term, regular and personalized treatment. However, under the pace of modern compact and fast-paced life, frequent and expensive treatment causes patients with chronic wounds of diabetes to feel tired and desperate, and many people often cannot follow medical advice, so that the wounds are worsened and finally even endanger life.
The clinical treatment of the diabetic wound is mainly debridement and wound dressing covering. The wound dressing not only can protect the wound from being damaged by environmental irritants, but also provides an optimal microenvironment so that the tissues of the wound can be continuously reconstructed. The chitosan has the advantages of good biocompatibility, degradability, no toxicity, antibiosis and the like, and the application potential in the aspect of dressing is continuously explored. The chitosan with high and low molecular weight has different pharmacological effects, such as the antibacterial effect of gram-positive bacteria staphylococcus aureus is gradually enhanced along with the increase of the molecular weight of the chitosan. In the case of gram-negative bacteria, the antibacterial action is gradually increased with the decrease in molecular weight. And the low molecular weight chitosan has relatively better moisturizing performance. Therefore, the molecular weights with different sizes are prepared into the chitosan mixture, and various advantages of the chitosan can be fully exerted. Nevertheless, chitosan dressings are less effective for the treatment of chronic wounds of diabetes. In recent years, people find that the pulse electrical stimulation has a more definite curative effect on treating chronic wounds. Because it can simulate endogenous damage current, it can induce the migration and proliferation of repairing cell and stimulate the secretion of several growth factors, so that it can promote the healing of wound surface. The treatment of diabetic wounds by electrical stimulation has gradually entered the clinic.
Most of the existing electrical stimulation devices are used independently, and the existing electrical stimulation devices are large in size, difficult to move, incapable of being remotely controlled and very inconvenient for patients to use. In addition, the diabetic wound has a long course of treatment, and the treatment of the wound is more difficult to keep regular. In addition, for the patients with diabetic wounds, the psychological construction before the electrical stimulation is very important for the physical and mental health of the patients. Therefore, the pulse electrical stimulation flexible electronic chitosan application capable of being controlled remotely is designed, and the pulse electrical stimulation device 7 is made of flexible electronic materials and is convenient to use. The preparation of flexible electronic material adopts "flexible printed circuit board" technique, uses polyimide as the substrate, adopts micro-nano processing technique, designs the special performance of can stretching of meandering structure in order to realize the device to promote the adaptability of device to the curved surface, reinforcing and the laminating degree of skin.
With the rapid development of computer science and information technology, remote medicine is driving the development of modern medical technology to wider and deeper fields exceeding 'space' and 'time' with astonishing speed and influence, developing new modes and new boundaries of medical services, breaking the limits of traditional medicine in 'environment', 'place' and other aspects, and playing a greater and greater role in improving the quality of life of people. The mobile phone and the computer are high-tech products, bring much convenience to life, and are necessities of life. The application function on the market is single at present, can not carry out the adjustment of electrical parameter according to the surface of a wound actual conditions, also does not have real-time monitoring function simultaneously, can not change treatment according to the monitoring result. Therefore, on the basis of combining the advantages of chitosan mixed liquid and electric stimulation, the change condition of the wound of the patient can be remotely monitored by utilizing a modern communication technology, and the treatment scheme is changed according to the wound condition, so that the greatest benefit is brought to the patient, and the time and the economic cost of the patient are saved.
Disclosure of Invention
The invention aims to solve the technical problem of the existing electrical stimulation defect, combines a wireless communication technology, electrical stimulation, a flexible printed circuit board technology, a sensor and a chitosan application, and provides a personalized, monitorable and controllable pulse electrical stimulation flexible electronic chitosan application capable of being remotely monitored and controlled.
In order to solve the technical problems, the invention adopts the technical scheme that: a remote monitoring and control flexible electronic chitosan application by pulse electrical stimulation comprises a terminal 1 and a flexible electronic chitosan application by pulse electrical stimulation 2.
The terminal 1 can be a mobile phone or a computer terminal and comprises an application program 3 of pulse electrical stimulation flexible electronic chitosan application and a terminal communication device 4, the application program 3 of the pulse electrical stimulation flexible electronic chitosan application comprises a patient information module 3-1, a wound surface real-time monitoring module 3-2, an electrical stimulation parameter module 3-3 and a communication module 3-4, and the patient information module 3-1 is used for providing basic information of a patient, such as information of age, sex, past history and the like. The wound real-time monitoring module 3-2 is used for providing information of the wound of the patient, such as temperature, humidity and pressure conditions; the electric stimulation parameter module 3-3 can set electric stimulation parameters and directly issue commands to the pulse electric stimulation flexible electronic chitosan application 2 of the patient, and the communication module 3-4 can send information to the mobile phone terminal of the patient, the family members of the patient and the mobile phone or the computer terminal of the doctor.
The shape of the pulse electrical stimulation flexible electronic chitosan application 2 can be various shapes, such as a square, a circle, a triangle and the like, and the shape and the size of the application are determined according to the shape of a wound.
The pulse electrical stimulation flexible electronic chitosan application 2 comprises a wireless communication device 5, a back lining layer 6, a pulse electrical stimulation device 7, a protective film 8, an early warning device 9, a medicine cushion layer 10, a wound environment monitoring sensor 11 and release paper 12. The pulse electrical stimulation flexible electronic chitosan application 2 is sequentially provided with a back lining layer 6, a pulse electrical stimulation device 7, a protective film 8 (the wireless communication device 5 and the early warning device 9 are simultaneously positioned between two layers of protective films 8), a medicine cushion layer 10, a wound environment monitoring sensor 11 and release paper 12 from the uppermost layer to the lowermost layer, and the wireless communication device 5 and the early warning device 9 are simultaneously positioned between two layers of protective films 8.
The back lining layer 6 is self-adhesive air-permeable polyurethane film, PU film, non-woven fabric, etc., which has viscosity and can be glued with the upper layer of the pulse electrical stimulation device 7, the protection film 8, the medicine cushion layer 10 and the exposed part of the outer side of the release paper 12 to form a whole. The exposed parts of the pulse electrical stimulation device 7, the protective film 8, the medicine cushion layer 10 and the release paper 12 are coated with medical adhesive at the same time, and the adhesion between each part and the backing layer 6 is reinforced. The pulse electrical stimulation device 7 is positioned in the center of the backing layer 6, and the positive electrode 7-10 and the negative electrode 7-11 of the pulse electrical stimulation device 7 penetrate through the protective film 8 (the upper layer and the lower layer) and the medicine pad layer 10. The protective film 8 has two layers, the upper layer is coated with medical adhesive and is connected with the pulse electrical stimulation device 7, and the lower layer is coated with medical adhesive and is connected with the medicine cushion layer 10. The wireless communication device 5 and the early warning device 9 are positioned between the two layers of protective films 8. The medical adhesive is smeared on the part below the medicine cushion layer 10 and is glued with the wound environment monitoring sensor 11, the medical adhesive is smeared on the medicine cushion layer 10 and is glued with the back lining layer 6 and the protective film 8 (lower layer), and the whole application integrity is reinforced. The release paper 12 is positioned below the drug pad layer 10 and the wound environment monitoring sensor 11.
The pulse electrical stimulation device 7 is made of flexible electronic materials, the flexible electronic materials are made by adopting a flexible printed circuit board technology, polyimide is used as a substrate, a special winding structure is designed to realize the stretching performance of the device, so that the adaptability of the device to a bent surface is improved, the fitting degree with the skin is enhanced, and the pulse electrical stimulation device is made by adopting a micro-nano processing technology. The pulse electrical stimulation device 7 is positioned in the center of the backing layer 6 and comprises a flexible substrate 7-1, a battery 7-2 (a button battery or a flexible film battery), a pulse switch circuit 7-3 (consisting of a direct current-direct current boosting module 7-4, a pulse modulation module 7-5 and a circuit switch 7-6), a current sensor 7-7, an electrical parameter control circuit 7-8, a lead 7-9, a peripheral positive electrode 7-10 and a central negative electrode 7-11. After the pulse electrical stimulation device 7 is manufactured, waterproof glue of a circuit board is sprayed, and short circuit caused by water infiltration is prevented.
The protective film 8 is an insulating material, and may be a high temperature resistant polyester film (PET film), an electrical insulating film, etc., and the protective film 8 may prevent water of the drug pad layer 10 from permeating the pulse electro-stimulation device 7, the early warning device 9, and the wireless communication device, and may prevent a short circuit of a circuit due to the insulating material.
The early warning device 9 is an electronic alarm and is connected with the current sensor 7-7 of the pulse electrical stimulation device 7 through a lead.
The terminal communication device 4 and the wireless communication device 5 can be selected from a Bluetooth communication device or a wireless communication device.
The medicinal pad layer 10 is a medical material with adsorption capacity, and can be absorbent cotton, medical gauze, medical sponge, medical cotton pad, medical cotton spunlace and the like; the chitosan mixture is adsorbed in the medicine cushion layer 10 and uniformly distributed, the chitosan mixture is composed of high molecular weight chitosan and low molecular weight chitosan, the high molecular weight chitosan with the molecular weight more than 10 ten thousand is high molecular weight chitosan, the low molecular weight chitosan with the molecular weight less than 10 ten thousand is low molecular weight chitosan, the high molecular weight chitosan and the low molecular weight chitosan are mixed according to the weight ratio of 1: 4-4: 1, the lower surface of the medicine cushion layer 10 is a mixture layer of vaseline and paraffin oil, and the vaseline and the paraffin oil are mixed according to the weight ratio of 1: 2-2: 1.
The wound environment monitoring sensor 11 comprises a temperature sensor 11-1, a humidity sensor 11-2 and a pressure sensor 11-3.
The terminal 1 comprises a mobile phone terminal of a patient or family members and a mobile phone or computer terminal of an attending doctor, the patient and the doctor can simultaneously obtain information of wound treatment, including electrical stimulation time and voltage, actual electrical stimulation time and voltage and the like, and according to the result of the wound environment monitoring sensor 11, the doctor can directly control application through the mobile phone or the computer terminal of the doctor or send medical advice to the mobile phone of the patient or the family members of the patient to adjust the treatment scheme.
The invention has the following advantages: 1) as for the common electrical stimulation equipment, the device needs to be used independently, has large volume and difficult movement, and is very inconvenient for patients to use. The pulse electrical stimulation flexible electronic device is small in size, convenient to carry, capable of achieving remote control, and capable of bringing great convenience to life of a patient. 2) The wound information of the patient can be monitored in real time, and the latest wound information can be obtained. 3) The parameters of the flexible electronic chitosan application by pulse electrical stimulation are adjusted according to the condition of the wound surface, and meanwhile, the parameters can be sent to patients or family members in real time to adjust the treatment scheme. 4) The advice of the diabetic chronic wound patients is improved efficiently and conveniently, the long-term regular treatment is really realized, and the treatment effect on the wound is more exact.
Drawings
Figure 1 is a schematic diagram of a remotely monitored and controlled pulsed electrical stimulation flexible electronic chitosan application.
Figure 2 is a control schematic of a remotely monitored and controlled pulsed electrical stimulation flexible electronic chitosan application.
Fig. 3 is a front view of a remote monitoring and control wound environment monitoring sensor 11 of the pulsed electrical stimulation flexible electronic chitosan application.
FIG. 4 is a functional schematic diagram of an application program of the pulsed electrical stimulation flexible electronic chitosan application of the present invention.
Fig. 5 is a front view of the pulsed electrical stimulation device of the present invention.
FIG. 6 is a comparative graph showing wound healing of the wound surface of diabetic rats to which the single-phase high-voltage pulse electrostimulation chitosan patch of this example 8 was applied.
FIG. 7 is the area and healing rate statistics of the wound surface of diabetic rats to which the single-phase high-voltage pulse electrostimulation chitosan patch of this example 8 was applied.
FIG. 8 is a comparison graph of wound healing promotion in diabetic rats by six groups of electrical parameters of the chitosan patch (surface electrode) for pulsed stimulation in different electrical parameters in the present example 9.
FIG. 9 is a chart showing statistics of wound healing rates of diabetic rats promoted by six groups of electrical parameters of the chitosan patch (surface electrode) for pulsed stimulation.
FIG. 10 is a chart showing statistics of the healing rate and the healing days of wound wounds of diabetic rats promoted by six groups of the pulsed electrical stimulation chitosan patches (surface electrodes) with different electrical parameters in the example 9.
FIG. 11 is a comparison of six groups of electrical parameters of the present example 10, in which the chitosan patch (inserted minimally invasive electrodes) stimulated by pulses promotes the healing of the wound of diabetic rat.
Fig. 12 is a statistic of wound healing rate of diabetic rat wounds promoted by six groups of electrical parameters of the chitosan patch (inserted minimally invasive electrodes) for pulse electrical stimulation in the present example 10.
Fig. 13 is a statistic of six groups of different electrical parameters of pulsed electrical stimulation chitosan application (inserted minimally invasive electrodes) in the present example 10 for promoting the healing rate of the wound surface of the diabetic rat and the healing days.
FIG. 14 shows the scratching test and the Transwell pattern of the HUVEC cells of example 11.
FIG. 15 shows the results of Western blotting and ELISA adsorption experiments in example 12.
The numbering in the figures illustrates:
1 terminal 2 pulse electrical stimulation flexible electronic chitosan application
Application program 4 terminal communication device with 3-pulse electrical stimulation flexible electronic chitosan application
5 backing layer of wireless communication device 6
7 pulse electro photoluminescence device 8 protection film
9 early warning device 10 medicine cushion layer
11 wound environmental monitoring sensor 12 is from type paper
7-1 Flexible substrate 7-2 Battery
7-3 pulse switch circuit 7-4 DC-DC boost module
7-5 pulse modulation module 7-6 circuit switch
7-7 current sensor 7-8 electrical parameter control circuit
7-9 lead 7-10 positive electrode
7-11 negative electrode
3-1 patient information module 3-2 wound surface real-time monitoring module
3-3 electrical stimulation parameter module 3-4 communication module
11-1 temperature sensor 11-2 humidity sensor
11-3 pressure sensors.
Detailed Description
The invention is further described with reference to the following figures and specific examples. The scope of the invention is not limited by the examples. It will be appreciated by those skilled in the art that changes and substitutions may be made in this embodiment without departing from the spirit of the invention, which is defined by the claims that follow.
Example 1 a remotely monitored and controlled pulsed electrically stimulated flexible electronic chitosan application,
referring to fig. 1, a remote monitoring and control pulse electrical stimulation flexible electronic chitosan application comprises a terminal 1 and a pulse electrical stimulation flexible electronic chitosan application 2.
See fig. 1-5. The terminal 1 can be a mobile phone or a computer terminal and comprises an application program 3 of pulse electrical stimulation flexible electronic chitosan application and a terminal communication device 4, the application program 3 of the pulse electrical stimulation flexible electronic chitosan application comprises a patient information module 3-1, a wound surface real-time monitoring module 3-2, an electrical stimulation parameter module 3-3 and a communication module 3-4, and the patient information module 3-1 is used for providing basic information of a patient, such as information of age, sex, past history and the like. The wound real-time monitoring module 3-2 is used for providing information of the wound of the patient, such as temperature, humidity and pressure conditions; the electric stimulation parameter module 3-3 can set electric stimulation parameters and directly issue commands to the pulse electric stimulation flexible electronic chitosan application 2 of the patient, and the communication module 3-4 can send information to the mobile phone terminal of the patient, the family members of the patient and the mobile phone or the computer terminal of the doctor.
The shape of the pulse electrical stimulation flexible electronic chitosan application 2 can be various shapes, such as a square, a circle, a triangle and the like, and the shape and the size of the application are determined according to the shape of a wound.
See fig. 1-5. The pulse electrical stimulation flexible electronic chitosan application 2 comprises a wireless communication device 5, a back lining layer 6, a pulse electrical stimulation device 7, a protective film 8, an early warning device 9, a medicine cushion layer 10, a wound environment monitoring sensor 11 and release paper 12. The pulse electrical stimulation flexible electronic chitosan application 2 is sequentially provided with a back lining layer 6, a pulse electrical stimulation device 7, a protective film 8 (the wireless communication device 5 and the early warning device 9 are simultaneously positioned between two layers of protective films 8), a medicine cushion layer 10, a wound environment monitoring sensor 11 and release paper 12 from the uppermost layer to the lowermost layer, and the wireless communication device 5 and the early warning device 9 are simultaneously positioned between two layers of protective films 8.
See fig. 1-5. The back lining layer 6 is self-adhesive air-permeable polyurethane film, PU film, non-woven fabric and the like, and has viscosity, and the back lining layer 6 is connected with the upper layer of the pulse electrical stimulation device 7, the protection film 8, the medicine cushion layer 10 and the part exposed outside the release paper 12 in an adhesive mode, so that the back lining layer 6, the protection film 8, the medicine cushion layer 10 and the release paper can be integrated. The exposed parts of the pulse electrical stimulation device 7, the protective film 8, the medicine cushion layer 10 and the release paper 12 are coated with medical adhesive at the same time, and the adhesion between each part and the backing layer 6 is reinforced. The pulse electrical stimulation device 7 is positioned in the center of the backing layer 6, and the positive electrode 7-10 and the negative electrode 7-11 of the pulse electrical stimulation device 7 penetrate through the protective film 8 (the upper layer and the lower layer) and the medicine pad layer 10. The protective film 8 has two layers, the upper layer is coated with medical adhesive and is connected with the pulse electrical stimulation device 7, and the lower layer is coated with medical adhesive and is connected with the medicine cushion layer 10. The wireless communication device 5 and the early warning device 9 are positioned between the two layers of protective films 8. The medical adhesive is smeared on the part below the medicine cushion layer 10 and is glued with the wound environment monitoring sensor 11, and the medical adhesive is smeared on the part above the medicine cushion layer and is glued with the protective film 8 on the upper layer. The release paper 12 is positioned below the drug pad layer 10 and the wound environment monitoring sensor 11. The backing layer 6 is the same size as the release paper 12. The lower protective film 8 and the medicine pad layer 10 are glued with the back lining layer 6 and the exposed part at the periphery of the release paper 12, the glue connection of each part with the back lining layer 6 and the release paper 12 is reinforced, and the whole application is integrated, wherein the exposed part at the outer side refers to the part of each layer which is not pasted with a part but is coated with an adhesive.
See fig. 1-5. The pulse electrical stimulation device 7 is made of flexible electronic materials, the flexible electronic materials are made by adopting a flexible printed circuit board technology, polyimide is used as a substrate, a special winding structure is designed to realize the stretching performance of the device, so that the adaptability of the device to a bent surface is improved, the fitting degree with the skin is enhanced, and the pulse electrical stimulation device is made by adopting a micro-nano processing technology. The pulse electrical stimulation device 7 is positioned in the center of the backing layer 6 and comprises a flexible substrate 7-1, a battery 7-2 (a button battery or a flexible film battery), a pulse switch circuit 7-3 (consisting of a direct current-direct current boosting module 7-4, a pulse modulation module 7-5 and a circuit switch 7-6), a current sensor 7-7, an electrical parameter control circuit 7-8, a lead 7-9, a peripheral positive electrode 7-10 and a central negative electrode 7-11. After the pulse electrical stimulation device 7 is manufactured, waterproof glue of a circuit board is sprayed, and short circuit caused by water infiltration is prevented.
The protective film 8 is an insulating material, and may be a high temperature resistant polyester film (PET film), an electrical insulating film, etc., and the protective film 8 may prevent water of the drug pad layer 10 from permeating the pulse electro-stimulation device 7, the early warning device 9, and the wireless communication device, and may prevent a short circuit of a circuit due to the insulating material. The upper protective film is matched and glued with the pulse electrical stimulation device, and the lower protective film is matched and glued with the medicine cushion layer.
The early warning device 9 is an electronic alarm and is connected with the current sensor 7-7 of the pulse electrical stimulation device 7 through a lead.
The terminal communication device 4 and the wireless communication device 5 can be selected from a Bluetooth communication device or a wireless communication device.
The medicinal pad layer 10 is a medical material with adsorption capacity, and can be absorbent cotton, medical gauze, medical sponge, medical cotton pad, medical cotton spunlace and the like; the chitosan mixture is adsorbed in the medicine cushion layer 10 and uniformly distributed, the chitosan mixture is composed of high molecular weight chitosan and low molecular weight chitosan, the high molecular weight chitosan with the molecular weight more than 10 ten thousand is high molecular weight chitosan, the low molecular weight chitosan with the molecular weight less than 10 ten thousand is low molecular weight chitosan, the high molecular weight chitosan and the low molecular weight chitosan are mixed according to the weight ratio of 1: 4-4: 1, the lower surface of the medicine cushion layer 10 is a mixture layer of vaseline and paraffin oil, and the vaseline and the paraffin oil are mixed according to the weight ratio of 1: 2-2: 1.
Referring to fig. 3, the wound environment monitoring sensor 11 comprises a temperature sensor 11-1, a humidity sensor 11-2 and a pressure sensor 11-3.
The terminal 1 comprises a mobile phone terminal of a patient or family members and a mobile phone or computer terminal of an attending doctor, the patient and the doctor can simultaneously obtain information of wound treatment, including electrical stimulation time and voltage, actual electrical stimulation time and voltage and the like, and according to the result of the wound environment monitoring sensor 11, the doctor can directly control application through the mobile phone or the computer terminal of the doctor or send medical advice to the mobile phone of the patient or the family members of the patient to adjust the treatment scheme.
EXAMPLE 2 remote monitoring and control of a flexible electronic chitosan dressing stimulated by electrical pulses (circular; capable of emitting 40V,100pps,100 μ s of electrical pulses; 3% chitosan in a mixture, 1:2 by weight of petrolatum to paraffin oil; monitored by a doctor and controlled by a cell phone)
Adding 1.5g of high molecular weight chitosan (molecular weight 100 ten thousand) and 1.5g of low molecular weight chitosan (molecular weight 5 thousand) into 97g of 1% acetic acid solution, stirring uniformly to obtain 3% chitosan mixed solution, filtering and sterilizing; and (3) immersing the medical sponge into the chitosan mixed solution for 24 hours, taking out the medical sponge, and drying the medical sponge in a drying oven at the temperature of 60-65 ℃ until water does not drip, thus obtaining the medical sponge containing 3% of chitosan mixed solution. Coating vaseline and paraffin oil mixture (weight ratio of vaseline to paraffin oil is 1:2, and sterilizing with high pressure steam) on the lower part of the dried medical sponge to obtain medicinal pad layer 10.
The early warning device 9 (an electronic alarm connected with the current sensor through a lead) and the wireless communication device 5 (a patch type DTU module E16) are connected with the pulse electrical stimulation device 7 and positioned between two layers of electrical insulating films (namely, a protective film 8).
The pulse electrical stimulation device 7 is arranged above the early warning device 9 and the wireless communication device 5, the pulse electrical stimulation device 7 comprises a flexible substrate 7-1, a battery 7-2 (a button battery), a pulse switch circuit 7-3 (composed of a direct current-direct current boosting module 7-4, a pulse modulation module 7-5 and a circuit switch 7-6), a current sensor 7-7, an electrical parameter control circuit 7-8, a lead 7-9, a peripheral positive electrode 7-10 and a central negative electrode 7-11, and the above structures except the flexible substrate 7-1 are connected through the lead 7-9. The electrodes of the pulsed electrical stimulation device 7 are gold electrodes comprising peripheral positive electrodes 7-10 and central negative electrodes 7-11, all passing through a protective film 8 (electrical insulation film) and a drug pad layer 10. The pulse power of 40V,100pps and 100 mus can be emitted.
The backing layer 6 is made of self-adhesive air-permeable polyurethane film, PU film, non-woven fabric, etc., has viscosity, and can be bonded with the exposed parts of the lower pulse electrical stimulation device 7, the protective film 8 (electrical insulation film), the drug cushion layer 10 and the release paper 12 to form a whole. The exposed parts of the lower-layer pulse electrical stimulation device 7, the protective film 8 (electrical insulating film), the drug cushion layer 10 and the release paper 12 are coated with medical adhesive at the same time, and the adhesion between each part and the backing layer 6 is reinforced. The wireless communication device and the early warning device 9 are positioned between the two layers of protective films 8, medical adhesive is smeared on the medicine cushion layer 10 and is connected with the protective films 8 (electrical insulation films) in an adhesive mode, the medical adhesive is locally smeared on the lower portion of the medicine cushion layer 10 and is connected with a wound environment monitoring sensor 11 (a temperature sensor: DS18B20 TO-92, a humidity sensor: HR202L and a pressure sensor: BF1K-3AA) in an adhesive mode, and the whole application is reinforced. Meanwhile, medical adhesive is smeared on the upper portion of the protective film 8 above the medicine cushion layer 10, so that the medicine cushion layer 10 is connected with the protective film 8 below the early warning device 9, the wireless communication device and the pulse electrical stimulation device 7, and the whole application integrity is reinforced. And single-sided glassine release paper 12 is stuck below the medicine cushion layer 10 to prepare the pulse electrical stimulation flexible electronic chitosan application.
The attending physician can adjust a suitable pulse electrical stimulation flexible electronic chitosan application, such as a circular application, with a radius of 3cm according to the wound condition of the patient. According to the condition of the first-time treated wound, a treatment scheme is established, and if the condition of the wound is poor, a prescription of stimulating 1h (40V,100pps,100 mus) per day can be given firstly. Patient tears after getting home and from type paper 12, cover the flexible electron chitosan of pulse electricity stimulation application to the chronic surface of a wound, after wound monitoring sensor produced the signal, send to doctor's cell-phone terminal through wireless communication device, the doctor can carry out the adjustment of treatment scheme according to the wound monitoring condition, directly issue the pulse electricity stimulation flexible electron chitosan application of order to patient through electro-stimulation parameter module, change the electro-stimulation scheme. The current sensor monitors whether a current load exists or not in each treatment period, if no current load exists, the current load is fed back to a doctor mobile phone terminal through the wireless communication device, the doctor remotely and forcibly starts the early warning device 9, the early warning device 9 prompts a patient through 5-sound early warning, and electrical stimulation treatment is directly carried out; if the current load exists, the actual treatment information is fed back to the computer terminal of the doctor through the wireless communication device, so that the patient is treated regularly and in a humanized manner.
EXAMPLE 3 remote monitoring and control of pulsed Electrical stimulation Flexible electronic Chitosan dressing (Square; pulsed Power at 30V,100pps,100 μ s; 1% Chitosan blend, 2:1 Vaseline to Paraffin oil weight ratio; doctor monitoring, patient control)
Adding 0.5g of high molecular weight chitosan (molecular weight of 20 ten thousand and 50 ten thousand half) and 0.5g of low molecular weight chitosan (molecular weight of 5 ten thousand and 10 ten thousand half) into 99g of 0.5% sorbic acid solution, stirring uniformly to obtain 1% chitosan mixed solution, sterilizing and filtering; and (3) immersing the medical gauze into the chitosan mixed solution for 12 hours, taking out the medical gauze, and drying the medical gauze for 6 hours in a freeze-drying machine to obtain the gauze containing the 3% chitosan mixed solution. Coating vaseline and paraffin oil mixture (weight ratio of vaseline to paraffin oil is 2: 1) on the lower part of the dried medical gauze, and sterilizing with high pressure steam to obtain medicinal pad layer 10.
The early warning device 9 (an electronic alarm connected with the current sensor through a lead) and the wireless network communication device (connected with the pulse electrical stimulation device 7) are positioned between the two layers of PET films (namely the protective film 8).
The pulse electrical stimulation device 7 is arranged above the early warning device 9 and the wireless network communication device, the pulse electrical stimulation device 7 comprises a flexible substrate 7-1, a battery 7-2 (a flexible film battery), a pulse switch circuit 7-3 (consisting of a direct current-direct current boosting module 7-4, a pulse modulation module 7-5 and a circuit switch 7-6), a current sensor 7-7, an electrical parameter control circuit 7-8, a lead 7-9, a peripheral positive electrode 7-10 and a central negative electrode 7-11, and the above structures except the flexible substrate 7-1 are connected through the lead 7-9. The electrodes of the pulse electrical stimulation device 7 are silver electrodes, and comprise positive electrodes 7-10 at the periphery and negative electrodes 7-11 at the center, and all the electrodes penetrate through a protective film 8(PET film) and a drug cushion layer 10. The pulse electrical stimulation device 7 can emit 30V,100pps and 100 mus pulse electricity.
The connection mode of the layers of the flexible electronic chitosan dressing by pulse electrical stimulation is the same as that of example 1.
The attending physician adapts a suitable pulsed electrical stimulation flexible electronic chitosan patch, such as a square, 3 x 3cm, to deliver a pulsed electrical stimulation of 30V,100pps,100 mus, depending on the patient's wound condition (size, shape, infection, necrosis, etc.). According to the condition of the wound to be treated for the first time, a treatment scheme is established, and if the condition of the wound is normal, a doctor can give an order of stimulating for 1h every 2 days. Patient tears release paper 12 after getting home, cover the flexible electron chitosan of pulse electro photoluminescence application to chronic surface of a wound, after wound monitoring sensor produced the signal, send to doctor's cell-phone terminal through wireless communication device, the doctor can carry out the adjustment of treatment scheme according to the wound monitoring condition, send information to patient's cell-phone terminal through communication module, change the electro photoluminescence scheme, patient controls the flexible electron chitosan of pulse electro photoluminescence application through cell-phone terminal by oneself and sends the electro photoluminescence. The current sensor monitors whether a current load exists or not in each treatment period, if no current load exists, the current load is fed back to a doctor computer terminal through a wireless communication device, a doctor remotely and forcibly starts the early warning device 9, the early warning device 9 prompts a patient through 5-sound early warning, and electrical stimulation treatment is directly carried out; if the current load exists, the actual treatment information is fed back to the computer terminal of the doctor through the wireless communication device, so that the patient is treated regularly and in a humanized manner.
EXAMPLE 4 remote monitoring and control of flexible electronic chitosan dressing stimulated by electrical pulses (rectangle; capable of emitting 50V,100pps,100 μ s of electrical pulses; 5% chitosan mixture, 1:1 weight ratio of vaseline to paraffin oil; doctor monitoring, family members controlled by mobile phone)
Adding 1g of high molecular weight chitosan (molecular weight is 20 ten thousand respectively) and 4g of low molecular weight chitosan (molecular weight is 5 thousand, 1 ten thousand is 1.5g respectively, molecular weight is 5 ten thousand and 1 ten thousand is 1g) into 95g of 1% sorbic acid solution, stirring uniformly to prepare 5% chitosan mixed solution, sterilizing and filtering; and (3) immersing the medical cotton pad into the chitosan mixed solution for 18 hours, taking out the cotton pad, and drying the cotton pad in a drying box at the temperature of 60-65 ℃ for 2 hours to obtain the cotton pad containing 5% of chitosan mixed solution. Coating vaseline and paraffin oil mixture (weight ratio of vaseline to paraffin oil is 1: 1) on the lower part of the dried medical sponge, and sterilizing with high pressure steam to obtain medicinal pad layer 10.
The early warning device 9 (an electronic alarm connected to the current sensor through a wire) and the bluetooth communication device (connected to the pulse electrical stimulation device 7) are located between two layers of electrical insulating films (i.e., the protective film 8).
The pulse electrical stimulation device 7 is arranged above the early warning device 9 and the Bluetooth communication device, the pulse electrical stimulation device 7 comprises a flexible substrate 7-1, a battery 7-2 (a button battery), a pulse switch circuit 7-3 (composed of a direct current-direct current boosting module 7-4, a pulse modulation module 7-5 and a circuit switch 7-6), a current sensor 7-7, an electrical parameter control circuit 7-8, a lead 7-9, a peripheral positive electrode 7-10 and a central negative electrode 7-11, and the above structures except the flexible substrate 7-1 are connected through the lead 7-9. The electrodes of the pulse electro-stimulation device 7 are titanium electrodes, and comprise positive electrodes 7-10 at the periphery and negative electrodes 7-11 at the center, all of which pass through a protective film 8 (electrical insulating film) and a drug pad layer 10. Can emit 50V,100pps and 100 mus pulse electricity
The connection mode of the layers of the flexible electronic chitosan dressing by pulse electrical stimulation is the same as that of example 1.
The attending physician adapts a suitable pulsed electrical stimulation flexible electronic chitosan patch, such as a rectangular patch, 5 x 10cm, to deliver pulsed electrical stimulation of 50V,100pps,100 mus, depending on the wound condition (size, shape, infection, necrosis, etc.) of the patient. According to the condition of the wound treated for the first time, a treatment scheme is established, if the condition of the wound is poor, a doctor can give a prescription for electrically stimulating for 1h 2 times every day at an interval of 6 h. The release paper 12 is torn after a patient goes home, the pulse electrical stimulation flexible electronic chitosan application is covered on a chronic wound surface, the wound monitoring sensor generates signals and sends the signals to a doctor mobile phone terminal through a wireless communication device, the doctor can adjust a treatment scheme according to the wound monitoring condition, information is sent to the mobile phone terminal of the family members of the patient through a communication module, the electrical stimulation scheme is changed, and the family members control the pulse electrical stimulation flexible electronic chitosan application to send electrical stimulation through the mobile phone terminal. The current sensor monitors whether a current load exists or not in each treatment period, if no current load exists, the current load is fed back to a doctor computer terminal through a wireless communication device, a doctor remotely and forcibly starts the early warning device 9, the early warning device 9 prompts the family members of the patient through 5-sound early warning, and electrical stimulation treatment is directly carried out; if the current load exists, the actual treatment information is fed back to the computer terminal of the doctor through the wireless communication device, so that the patient is treated regularly and in a humanized manner.
EXAMPLE 5 remote monitoring and control of a flexible electro-pulsed chitosan application (circular; capable of emitting pulsed electricity at 60V,105pps,80 μ s; 5% chitosan mixture, 1:2 by weight Vaseline to paraffin oil; monitored by a physician and controlled by a computer)
Adding 5g of a mixture of high molecular weight and low molecular weight chitosans (1 g of each of the molecular weights of 3 thousand, 5 ten thousand, 20 ten thousand, 30 ten thousand and 80 ten thousand) into 95g of 1% acetic acid solution, stirring uniformly to obtain 5% chitosan mixed solution, sterilizing and filtering; and (3) immersing the medical sponge into the chitosan mixed solution for 24 hours, taking out the sponge, and drying the sponge for 12 hours in a freeze-drying machine until no water drops, thus preparing the medical sponge containing 5% of chitosan mixed solution. Coating vaseline and paraffin oil mixture (weight ratio of vaseline to paraffin oil is 1:2, and sterilizing with high pressure steam) on the lower part of the dried medical sponge to obtain medicinal pad layer 10.
The early warning device 9 (an electronic alarm connected with the current sensor through a lead) and the wireless network communication device (connected with the pulse electrical stimulation device 7) are positioned between the two layers of PET films (namely the protective film 8).
The pulse electrical stimulation device 7 is arranged above the early warning device 9 and the wireless network communication device, the pulse electrical stimulation device 7 comprises a flexible substrate 7-1, a battery 7-2 (a flexible film battery), a pulse switch circuit 7-3 (consisting of a direct current-direct current boosting module 7-4, a pulse modulation module 7-5 and a circuit switch 7-6), a current sensor 7-7, an electrical parameter control circuit 7-8, a lead 7-9, a peripheral positive electrode 7-10 and a central negative electrode 7-11, and the above structures except the flexible substrate 7-1 are connected through the lead 7-9. The electrodes of the pulse electrical stimulation device 7 are titanium electrodes, and comprise positive electrodes 7-10 at the periphery and negative electrodes 7-11 at the center, and all the electrodes penetrate through a protective film 8(PET film) and a medicine pad layer 10. The pulse electrical stimulation device 7 can emit 60V,105pps and 80 mus pulse electricity.
The connection mode of the layers of the flexible electronic chitosan dressing by pulse electrical stimulation is the same as that of example 1.
The attending physician adapts a suitable pulsed electrical stimulation flexible electronic chitosan patch, such as a circular patch, with a 5cm radius, according to the wound condition (size, shape, infection, necrosis, etc.) of the patient. According to the wound condition of the first diagnosis, a treatment plan is established, and if the wound condition is better, the treatment plan can give a prescription of electrical stimulation for 1h every 2 days (60V,105pps,80 mus). Patient tears after getting home and from type paper 12, with the flexible electron chitosan of pulse electricity stimulation apply ointment or plaster cover to chronic surface of a wound, after wound monitoring sensor produced the signal, send to doctor's computer terminal through wireless communication device, the doctor can carry out the adjustment of treatment scheme according to the wound monitoring condition, directly issue the pulse electricity stimulation flexible electron chitosan that orders to patient through electro-stimulation parameter module and apply ointment or plaster, change the electro-stimulation scheme. The current sensor monitors whether a current load exists or not in each treatment period, if no current load exists, the current load is fed back to a doctor computer terminal through a wireless communication device, a doctor remotely and forcibly starts the early warning device 9, the early warning device 9 prompts a patient through 5-sound early warning, and electrical stimulation treatment is directly carried out; if the current load exists, the actual treatment information is fed back to the computer terminal of the doctor through the wireless communication device, so that the patient is treated regularly and in a humanized manner.
EXAMPLE 6 remote monitoring and control of a flexible electronic chitosan patch stimulated by electrical pulses (Square; 80V,105pps,80 μ s pulsed electricity; 1% chitosan mixture, 1:1 by weight Vaseline to paraffin oil; monitored by doctor and controlled by mobile phone)
Adding 0.5g of high molecular weight chitosan (molecular weight of 20 ten thousand and 50 ten thousand half) and 0.5g of low molecular weight chitosan (molecular weight of 5 ten thousand and 10 ten thousand half) into 99g of 0.5% citric acid solution, stirring uniformly to obtain 1% chitosan mixed solution, sterilizing and filtering; and (3) soaking the absorbent cotton into the chitosan mixed solution for 24 hours, taking out the absorbent cotton, and drying the absorbent cotton in a freeze-drying machine for 12 hours to obtain the absorbent cotton containing 1% of chitosan mixed solution. Coating vaseline and paraffin oil mixture (weight ratio of vaseline to paraffin oil is 1: 1) on the lower part of the dried absorbent cotton, and sterilizing with high pressure steam to obtain medicinal pad layer 10.
The early warning device 9 (an electronic alarm connected to the current sensor through a wire) and the wireless network communication device (connected to the pulse electrical stimulation device 7) are located between two layers of electrical insulation film (i.e., the protective film 8).
The early warning device 9 and the wireless network communication device are provided with the pulse electrical stimulation device 7 above, the pulse electrical stimulation device 7 comprises a flexible substrate 7-1, a battery 7-2 (a button battery), a pulse switch circuit 7-3 (composed of a direct current-direct current boosting module 7-4, a pulse modulation module 7-5 and a circuit switch 7-6), a current sensor 7-7, an electrical parameter control circuit 7-8, a lead 7-9, a peripheral positive electrode 7-10 and a central negative electrode 7-11, and the above structures except the flexible substrate 7-1 are connected through the lead 7-9. The electrodes of the pulsed electrical stimulation device 7 are gold electrodes comprising peripheral positive electrodes 7-10 and central negative electrodes 7-11, all passing through a protective film 8 (electrical insulation film) and a drug pad layer 10. The pulse electrical stimulation device 7 can emit 80V,105pps and 80 mus pulse electricity.
The connection mode of the layers of the flexible electronic chitosan dressing by pulse electrical stimulation is the same as that of example 1.
The attending physician adapts a suitable pulsed electrical stimulation flexible electronic chitosan patch, such as a square patch, 5 x 5cm, depending on the wound condition (size, shape, infection, necrosis, etc.) of the patient. Based on the first treated wound condition, a treatment plan is established, and if the wound condition is poor, the treatment plan can be prescribed by giving 1h of daily electrical stimulation (80V,105pps,80 mus). Patient tears after getting home and from type paper 12, cover the flexible electron chitosan of pulse electricity stimulation application to the chronic surface of a wound, after wound monitoring sensor produced the signal, send to doctor's cell-phone terminal through wireless communication device, the doctor can carry out the adjustment of treatment scheme according to the wound monitoring condition, directly issue the pulse electricity stimulation flexible electron chitosan application of order to patient through electro-stimulation parameter module, change the electro-stimulation scheme. The current sensor monitors whether a current load exists or not in each treatment period, if no current load exists, the current load is fed back to a doctor mobile phone terminal through the wireless communication device, the doctor remotely and forcibly starts the early warning device 9, the early warning device 9 prompts a patient through 5-sound early warning, and electrical stimulation treatment is directly carried out; if the current load exists, the actual treatment information is fed back to the mobile phone terminal of the doctor through the wireless communication device, so that the patient is treated regularly and in a humanized manner.
EXAMPLE 7 remote monitoring and control of a flexible electronic chitosan dressing stimulated by electrical pulses (rectangle; capable of emitting 80V,100pps,100 μ s pulsed electricity; 5% chitosan mixed liquor, 2:1 by weight of vaseline and paraffin oil; doctor monitoring, family members controlled by mobile phone)
Adding 2.5g of high molecular weight chitosan (molecular weight of 20 ten thousand and 50 ten thousand and half) and 2.5g of low molecular weight chitosan (molecular weight of 5 ten thousand and 10 ten thousand and half) into 95g of 1% acetic acid solution, stirring uniformly to obtain 5% chitosan mixed solution, sterilizing and filtering; and uniformly spraying the mixed solution on medical gauze, taking out the medical gauze, and drying the medical gauze in an oven at the temperature of 60-65 ℃ for 12 hours to prepare the washing cotton containing 5% of chitosan mixed solution. Coating vaseline and paraffin oil mixture (weight ratio of vaseline to paraffin oil is 2: 1) on the lower part of the dried absorbent cotton, and sterilizing with high pressure steam to obtain medicinal pad layer 10.
The early warning device 9 (an electronic alarm connected with the current sensor through a wire) and the Bluetooth communication device (connected with the pulse electrical stimulation device 7) are positioned between the two layers of PET films (namely the protective film 8).
The pulse electrical stimulation device 7 is arranged above the early warning device 9 and the Bluetooth communication device, the pulse electrical stimulation device 7 comprises a flexible substrate 7-1, a battery 7-2 (a button battery or a flexible film battery), a pulse switch circuit 7-3 (composed of a direct current-direct current boosting module 7-4, a pulse modulation module 7-5 and a circuit switch 7-6), a current sensor 7-7, an electrical parameter control circuit 7-8, a lead 7-9, a peripheral positive electrode 7-10 and a central negative electrode 7-11, and the above structures except the flexible substrate 7-1 are connected through the lead 7-9. The electrodes of the pulse electrical stimulation device 7 are silver electrodes, and comprise positive electrodes 7-10 at the periphery and negative electrodes 7-11 at the center, and all the electrodes penetrate through a protective film 8(PET film) and a drug cushion layer 10. The pulse electrical stimulation device 7 can emit 80V,100pps and 100 mus pulse electricity.
The connection mode of the layers of the flexible electronic chitosan dressing by pulse electrical stimulation is the same as that of example 1.
The attending physician adapts a suitable pulsed electrical stimulation flexible electronic chitosan patch, such as a rectangle, 10 x 10cm, depending on the wound condition (size, shape, infection, necrosis, etc.) of the patient. Based on the first treated wound condition, a treatment plan is established, if the wound condition is poor, and a prescription (80V,100pps,100 mus) of 2 times per day and 1h of 6h electric stimulation is given. Patient tears release paper 12 after going home, cover the flexible electron chitosan of pulse electricity stimulation application to chronic surface of a wound, after wound monitoring sensor produced the signal, send to doctor's cell-phone terminal through wireless communication device, the doctor can carry out the adjustment of treatment scheme according to the wound monitoring condition, issue the cell-phone terminal of order to patient's family members through communication module, family members's flexible electron chitosan of pulse electricity stimulation application of electrical stimulation module direct control patient through cell-phone terminal. The current sensor monitors whether a current load exists or not in each treatment period, if no current load exists, the current load is fed back to a doctor mobile phone terminal through the wireless communication device, the doctor remotely and forcibly starts the early warning device 9, the early warning device 9 prompts a patient through 5-sound early warning, and electrical stimulation treatment is directly carried out; if the current load exists, the actual treatment information is fed back to the mobile phone terminal of the doctor through the wireless communication device, so that the patient is treated regularly and in a humanized manner.
EXAMPLE 8 Experimental study on the promotion of wound healing in diabetic rats by a single-phase high-voltage pulse electrostimulation flexible electronic chitosan application (Electrical parameters: 40V,100pps,100 μ s)
Normal SD rats were fed with a high-fat and high-sugar diet for one month and then injected with STZ (35mg/kg) to measure blood glucose. Random blood glucose>16.7mmol/L is the standard for model building success of type II diabetic rats. Taking 12 type II diabetes rats successfully molded, inducing and maintaining with gas anesthetic (isoflurane), preparing skin, and making 2 × 2cm incision of skin layer (including flesh membrane) at 2cm around the left and right parts of spinal column2Square wound surface of (2). The parameters of the pulse electrical stimulation device applied by the pulse electrical stimulation chitosan are set to 40V,100pps and 100 mus, and then the pulse electrical stimulation device is placed on the wound surface of a diabetic rat. The left wound was the control group and the right wound was the experimental group. Every 2 days for 1 hour. Photographs were taken at 3 rd, 7 th, 14 th and 21 st after surgery to record wound healing. The area of the wound surface was measured by Image J software, and statistical analysis of data was performed by GraphPad Prism software, data are expressed as SD + -SEM, p<A difference of 0.05 is statistically significant.
Fig. 6 is a comparison graph of wound healing of the single-phase high-voltage pulse electrostimulation chitosan patch applied to the wound of diabetic rats in the embodiment 8, which is photographs of the wound on days 3, 7, 14 and 21. The left wound was the control group and the right wound was the experimental group. The results of the study showed that the wound surface covered with the single-phase high-voltage pulse electrostimulation chitosan patch healed faster than the control group, as shown in fig. 7. A is a statistical chart of the wound area of a single-phase high-voltage group; b is a statistical chart of the wound healing rate of the monophasic high-voltage group. The results show that the application of the monophasic high-voltage pulse electrical stimulation chitosan (electrical parameters: 40V,100pps,100 mus) can accelerate the healing of the wound of the diabetic rat.
EXAMPLE 96 Experimental study of groups of Electrical stimulation with different electrical parameters on chitosan application (surface electrode) to promote wound healing in diabetic rats
Normal SD rats were fed with a high-fat and high-sugar diet for one month and then injected with STZ (35mg/kg) to measure blood glucose. The random blood sugar of more than 16.7mmol/L is the standard for the model building success of the type II diabetic rats. 72 type II diabetic rats successfully molded were randomly divided into 6 groups (12 rats per group), and the electrical parameters were grouped into a single-phase high-voltage group (40V, 100. mu.s, 100pps), a single-phase low-voltage group (4V, 100. mu.s, 100pps), a single high-voltage + direct current (40V, 100. mu.s, 100 pps; 4V), a direct current group (4V), a two-phase high-voltage group (. + -. 40V, 100. mu.s, 100pps), and a two-phase low-voltage group (. + -. 4V, 100. mu.s, 100 pps).
Maintaining under induction of gas anesthetic (isoflurane), preparing skin, and making 2 × 2cm incision on the left and right sides of spinal column at 2cm2Square wound surface of (2). Then an electrode (surface electrode) applied with chitosan by pulse electrical stimulation is placed on the wound surface of a diabetic rat, a negative electrode is placed at the center of the wound surface, and a positive electrode is placed at a normal skin position 1cm away from the edge of the wound. The left wound was the control group and the right wound was the experimental group. Every 2 days for 1 hour. Photographs were taken at 3 rd, 7 th, 14 th and 21 st after surgery to record wound healing. The area of the wound surface was measured by Image J software, and statistical analysis of data was performed by GraphPad Prism software, data are expressed as SD + -SEM, p<A difference of 0.05 is statistically significant.
Fig. 8 is a photograph of wound surface of diabetic rat on days 3, 7, 14 and 21 obtained by applying 6 groups of pulse electrical stimulation chitosan patches with different electrical parameters in example 9, wherein the left side wound surface is a control group, and the right side wound surface is an electrical stimulation experimental group.
Referring to fig. 9 and 10, wherein fig. 9A-D are statistical plots of the healing rate for 6 sets of different electrical parameters of pulsed electrical stimulation of chitosan application days 3, 7, 14, 21; fig. 10A-D are statistical graphs of the healing-promoting rates for 6 groups of different electrical parameters of pulsed electrical stimulation chitosan applications on days 3, 7, 14, and 21 (experimental group-control wound healing rate); fig. 10E is a line graph of a statistical graph of the healing-promoting rates (experimental group healing rate-control wound healing rate) for 6 groups of pulsed electrical stimulation chitosan patches with different electrical parameters on days 3, 7, 14, and 21; FIG. 10F is a comparison of the number of healing days for 6 sets of pulsed electrical stimulation of chitosan applications with different electrical parameters; experimental results show that the single-phase high-voltage pulse electrical stimulation group and the single-phase high-voltage pulse electrical stimulation and direct current electrical group can promote healing of the type II diabetic wound (fig. 9A-D), and the unidirectional high-voltage pulse electrical stimulation group (HVMPC) is found to be the optimal electrical stimulation parameter by comparing data of 6 groups of different electrical parameters. And (4) prompting by a result: unidirectional high voltage pulsed electrical stimulation (HVMPC) may be the optimal electrical stimulation.
EXAMPLE 106 Experimental study of groups of different electrical parameters of pulsed electrostimulation chitosan application (inserted minimally invasive electrodes) to promote healing of diabetic rat wound
Normal SD rats were fed with a high-fat and high-sugar diet for one month and then injected with STZ (35mg/kg) to measure blood glucose. The random blood sugar of more than 16.7mmol/L is the standard for the model building success of the type II diabetic rats. 72 type II diabetic rats successfully molded are randomly divided into 6 groups (12 rats in each group), namely a monophasic high-voltage pulse electrical stimulation group (40v,100pps,100 mus), a monophasic low-voltage pulse electrical stimulation group (4v,100 pps,100 mus), a biphasic high-voltage pulse electrical stimulation group (40v,100pps,100 mus), a biphasic low-voltage pulse electrical stimulation group (4v,100 pps,100 mus), a direct-current electrical stimulation group (4v) and a monophasic high-voltage pulse electrical stimulation composite direct-current electrical stimulation group (40v,100pps,100 mus; 4 v).
Maintaining under induction of gas anesthetic (isoflurane), preparing skin, and making 2 × 2cm incision on the left and right sides of spinal column at 2cm2Square wound surface of (2). Then, an electrode (an inserted minimally invasive electrode) applied with chitosan through pulse electrical stimulation is placed on the wound surface of a diabetic rat, a negative electrode is placed in the center of the wound surface, and a positive electrode is placed on a normal skin position 1cm away from the edge of the wound. The left wound was the control group and the right wound was the experimental group. Every 2 days for 1 hour. Photographs were taken at 3 rd, 7 th, 14 th and 21 st after surgery to record wound healing. The area of the wound surface was measured with Image J software, and statistical analysis of the data, expressed as SD + -SEM, p, was performed with GraphPadprism software<A difference of 0.05 is statistically significant.
Referring to fig. 11, it is a photograph of wound surface of diabetic rat on days 3, 7, 14, and 21 with 6 groups of electrical stimulation chitosan application (inserted minimally invasive electrodes) with different electrical parameters applied in this example 10, the left side wound surface is a control group, and the right side wound surface is an electrical stimulation experimental group.
Referring to fig. 12 and 13, wherein fig. 12A-D are statistical plots of the healing rates of 6 sets of electrical parameters of pulsed electrostimulated chitosan patches (inserted minimally invasive electrodes) applied to diabetic rat wounds on days 3, 7, 14, and 21; fig. 13A-D are statistical graphs of the healing-promoting rates for 6 groups of different electrical parameters of pulsed electrical stimulation chitosan application (inserted minimally invasive electrodes) on days 3, 7, 14, and 21 (experimental group healing-control wound healing); fig. 13E is a line graph of a statistical graph of the healing-promoting rates (experimental group healing rate-control wound healing rate) for 6 groups of pulsed electrical stimulation chitosan patches (inserted minimally invasive electrodes) with different electrical parameters on days 3, 7, 14, and 21; figure 13F is a comparison of the number of healing days for 6 sets of pulsed electrical stimulation chitosan applications (inserted minimally invasive electrodes) of different electrical parameters.
The impedance of the rat wound surface epidermis is the maximum, so the positive electrode surface electrode is improved into an insertion type minimally invasive electrode. However, experimental results found that monophasic high voltage pulsed electricity was the best electrical stimulation parameter in 6 groups as was the preferred result of experiments with surface electrodes (fig. 11-13). The healing rate of the right side electrical stimulation treatment wound of the unidirectional high voltage only group was faster than the left side control wound, and the right side electrical stimulation wound of the direct current group was even slower than the left side control group (fig. 12-13). Compared with the prior surface electrode, the minimally invasive electrode has no more obvious effect of promoting wound healing, the electric current is too large due to too small resistance between the two electrodes to generate heat effect, so that the skin is burnt, 4 groups of electric stimulation groups have electric burn phenomena, and 2 groups of injuries with direct current are more obvious (HVMPC and HVMPC + DC groups, figure 11). And (4) prompting by a result: the electrode for electrical stimulation is preferably a surface electrode.
Example 11 in vitro experiment of Electrical stimulation to promote migration of HUVEC cells
HUVEC cultured in high-sugar and high-fat (25mmol/L D-glucose and 0.4mM sodium palmitate) environment simulates in-vivo environment of diabetes, and whether electrical stimulation can promote migration of HUVEC cells is studied by using a scratch test and a Transwell migration test. Cell scratch assay is a useful assay to study cell migration in vitro. The principle is that a blank cell-free zone is artificially made in a single layer of plated cells, and then cells at the edge of the cell-free zone are observed; the cells at these edges will begin to migrate and eventually cover the entire cell-free area and come back into contact with each other. The Tanswell experiment principle is that a Transwell chamber is placed in a culture plate, an upper chamber is called in the chamber, a lower chamber is called in the culture plate, an upper layer culture solution is contained in the upper chamber, a lower layer culture solution is contained in the lower chamber, and the upper layer culture solution and the lower layer culture solution are separated by a polycarbonate membrane. When the cells are planted in the upper chamber, due to permeability of the polycarbonate membrane, the components in the lower layer culture solution can affect the cells in the upper chamber, the cells can run to the lower chamber with high nutrient content, the migration capacity of the cells can be reflected by counting the amount of the cells entering the lower chamber, and therefore the influence of the components in the lower layer culture solution on the growth, movement and the like of the cells can be researched.
FIG. 14 shows the results of the in vitro experiment of this example 11 in which electrical stimulation promoted migration of HUVEC cells. The experiments were grouped into control groups (control, no electrical stimulation applied), and 4 electrical stimulation experimental groups: 4V 5min, 4V 10min, 40V, 5min and 40V,10 min. FIG. 14A is a graph of gentian violet staining after 12h of a Transwell experiment; FIG. 14B is a graph of migration after 12h, 24h, and 36h of cell scratch experiments; fig. 14C is a mobility statistic of the cell scratch experiment (14B). The experimental result shows that the electrical stimulation can promote the migration of HUVEC, thereby being beneficial to the migration of repairing cells to the wound surface and participating in the healing process.
Example 12 Electrical stimulation promotes secretion of various growth factors by HUVEC cells
HUVECs cultured in high-sugar, high-lipid (25 mmol/LD-glucose, 0.4mM sodium palmitate) environment mimic the diabetic in vivo environment. HUVEC cells secreting various growth factors were detected by Western immunoblotting (WB) and enzyme-linked immunosorbent assay (ELISA). The WB assay is a method for detecting a certain protein in a complex sample based on specific binding of antigen-antibody. The method is a new immune biochemical technology developed on the basis of gel electrophoresis and solid-phase immunoassay, has the high resolution of SDS-PAGE and the high specificity and sensitivity of solid-phase immunoassay, and is a conventional technology for protein analysis. Immunoblotting is commonly used to identify certain proteins and enables qualitative and semi-quantitative analysis of proteins. In the ELISA test, a known antigen or antibody is adsorbed on the surface of a solid phase carrier, and an enzyme-labeled antigen-antibody reaction is allowed to proceed on the surface of the solid phase. The technology can be used for detecting macromolecular antigens, specific antibodies and the like, and has the advantages of rapidness, sensitivity, simplicity, convenience, easy standardization of carriers and the like.
FIG. 15 shows the results of experiments conducted by the present example 12 in which electrical stimulation promoted secretion of various factors by HUVEC cells. Groups were divided into control (no electrical stimulation applied), and 4 electrical stimulation experimental groups: 4V 5min, 4V 10min, 40V, 5min and 40 fruit statistics. As a result, the experimental group was found to be able to promote the expression of VEGF, FGF-2, TGF-beta 1, Akt, p-ERK1/2, from V,10 min, compared with the control group. FIG. 15A is a Western blot chart; FIG. 15B is a statistic of relative protein expression; fig. 15C shows Elisa knots of VEGF to accelerate wound healing.

Claims (10)

1. The flexible electronic chitosan application for remote monitoring and control through pulse electrical stimulation is characterized by consisting of a terminal (1) and a flexible electronic chitosan application (2) for pulse electrical stimulation, wherein the terminal (1) is a mobile phone or a computer terminal and comprises an application program (3) applied with the flexible electronic chitosan through pulse electrical stimulation and a terminal communication device (4); pulse electrical stimulation flexible electron chitosan applies ointment or plaster (2) and includes wireless communication device (5), back sheet (6), pulse electrical stimulation device (7), protection film (8), early warning device (9), medicine bed course (10), wound environment monitoring sensor (11) and from type paper (12), and follow back sheet (6), pulse electrical stimulation device (7), protection film (8), medicine bed course (10), wound environment monitoring sensor (11) and from type paper (12) top-down connect gradually, wherein, protection film (8) have two-layerly, wireless communication device (5) and early warning device (9) are located between two-layer protection film (8) simultaneously.
2. The remotely monitored and controlled pulsed electrical stimulation flexible electronic chitosan application of claim 1, wherein the pulsed electrical stimulation flexible electronic chitosan application program (3) comprises a patient information module (3-1), a wound real-time monitoring module (3-2), an electrical stimulation parameter module (3-3) and a communication module (3-4).
3. The remote monitoring and controlling pulse electrical stimulation flexible electronic chitosan application as claimed in claim 1, wherein the pulse electrical stimulation device (7) is located in the center of the backing layer (6), the positive electrodes (7-10) and the negative electrodes (7-11) of the pulse electrical stimulation device (7) penetrate through the two protective films (8) and the drug cushion layer (10), the protective film (8) has two layers, the upper protective film (8) is connected with the pulse electrical stimulation device (7) in an adhesive manner, the lower protective film (8) is connected with the drug cushion layer (10) in an adhesive manner, the upper surface and the lower surface of the drug cushion layer (10) are coated with medical adhesive, the lower surface of the drug cushion layer is connected with the wound environment monitoring sensor (11) in an adhesive manner, the upper surface of the drug cushion layer is connected with the upper protective film (8) in an adhesive manner, the lower protective film (8) and the drug cushion layer (10) are connected with the backing layer (6) and, are formed into a whole.
4. The remotely monitored and controlled pulse electrical stimulation flexible electronic chitosan application as claimed in claim 1 or 3, wherein the pulse electrical stimulation device (7) comprises a flexible substrate (7-1), a battery (7-2), a pulse switch circuit (7-3), a current sensor (7-7), an electrical parameter control circuit (7-8), a lead (7-9), a peripheral positive electrode (7-10) and a central negative electrode (7-11), wherein the battery (7-2) is selected from a button battery or a flexible thin film battery; the pulse switch circuit (7-3) is composed of a direct current-direct current boosting module (7-4), a pulse modulation module (7-5) and a circuit switch (7-6).
5. A remotely monitored and controlled pulsed electrically stimulated flexible electronic chitosan dressing according to claim 1 or 3, wherein the pre-warning device (9) is an electronic alarm connected by wires to the current sensors (7-7) of the pulsed electrical stimulation device (7).
6. The remotely monitored and controlled pulse electrical stimulation flexible electronic chitosan application as claimed in claim 1 or 3, wherein the chitosan mixture is adsorbed in the drug pad layer (10) and uniformly distributed, the chitosan mixture is composed of chitosan with high molecular weight and chitosan with low molecular weight, the chitosan with molecular weight more than 10 ten thousand is chitosan with high molecular weight, the chitosan with molecular weight less than 10 ten thousand is chitosan with low molecular weight, the chitosan with high and low molecular weight is mixed according to the weight ratio of 1: 4-4: 1, the lower surface of the drug pad layer (10) is a mixture layer of vaseline and paraffin oil, and the vaseline and paraffin oil are mixed according to the weight ratio of 1: 2-2: 1.
7. A remotely monitored and controlled pulsed electrical stimulation flexible electronic chitosan dressing according to claim 1 or 3, wherein said wound environment monitoring sensors (11) comprise temperature sensors (11-1), humidity sensors (11-2), pressure sensors (11-3).
8. The remotely monitored and controlled pulse electrical stimulation flexible electronic chitosan application as set forth in claim 1 or 3, wherein said backing layer (6) is selected from self-adhesive breathable polyurethane film, PU film, non-woven fabric; the pulse electrical stimulation device (7) is made of flexible electronic materials; the protective film (8) is made of an insulating material, and a high-temperature resistant polyester film and an electrical insulating film are selected; the medical pad layer (10) is made of medical materials with adsorption capacity, and is made of absorbent cotton, medical gauze, medical sponge, medical cotton pad and medical cotton spunlace cloth; the terminal communication device (4) and the wireless communication device (5) are selected from a Bluetooth communication device or a wireless communication device.
9. A remotely monitored and controlled pulsed electrically stimulated flexible electronic chitosan dressing according to claim 1 or 3, wherein said pulsed electrically stimulated flexible electronic chitosan dressing (2) is square, circular, triangular, polygonal in shape, the shape and size of which are determined in particular by the shape of the wound.
10. The remotely monitored and controlled pulse electrical stimulation flexible electronic chitosan application as claimed in claim 1 or 3, wherein after the pulse electrical stimulation device (7) is manufactured, a waterproof glue for a circuit board is sprayed to prevent water from permeating to cause short circuit.
CN201910864125.1A 2019-09-12 2019-09-12 Remote monitoring and control pulse electric stimulation flexible electronic chitosan application Pending CN110665118A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910864125.1A CN110665118A (en) 2019-09-12 2019-09-12 Remote monitoring and control pulse electric stimulation flexible electronic chitosan application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910864125.1A CN110665118A (en) 2019-09-12 2019-09-12 Remote monitoring and control pulse electric stimulation flexible electronic chitosan application

Publications (1)

Publication Number Publication Date
CN110665118A true CN110665118A (en) 2020-01-10

Family

ID=69077886

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910864125.1A Pending CN110665118A (en) 2019-09-12 2019-09-12 Remote monitoring and control pulse electric stimulation flexible electronic chitosan application

Country Status (1)

Country Link
CN (1) CN110665118A (en)

Similar Documents

Publication Publication Date Title
AU2016262720B2 (en) Expandable wound dressings
US6087549A (en) Multilayer laminate wound dressing
US10206604B2 (en) Arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing
US10166387B2 (en) Arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing
ES2430688T3 (en) Medical device
US8093444B2 (en) Multilayer conductive appliance having wound healing and analgesic properties
US7291762B2 (en) Multilayer conductive appliance having wound healing and analgesic properties
US8328858B2 (en) Infrared wound healing unit
CN211634892U (en) Remote monitoring and drug release pulse electrical stimulation flexible electronic chitosan application
CN113262105B (en) Wound dressing based on piezoelectric effect and preparation method thereof
CN211611320U (en) Remote monitoring and control pulse electric stimulation flexible electronic chitosan application
CN211611319U (en) Remote control&#39;s flexible electron chitosan of pulse electrical stimulation is applied ointment or plaster
CN110665118A (en) Remote monitoring and control pulse electric stimulation flexible electronic chitosan application
CN110665119A (en) Remote control&#39;s flexible electron chitosan of pulse electrical stimulation is applied ointment or plaster
CN110665120A (en) Remote monitoring and drug release pulse electrical stimulation flexible electronic chitosan application
CN211611318U (en) Pulse electrical stimulation flexible electronic chitosan application
Gnanasambanthan et al. Development of a flexible and wearable microelectrode array patch using a screen-printed masking technique for accelerated wound healing
CN112473004A (en) Pulse electrical stimulation flexible electronic chitosan application
CN2621668Y (en) Instant magnetic medicinal plaster
CN207871271U (en) A kind of medical silicone gel scar plaster
US20230158283A1 (en) Systems and methods for a smart bandage for monitoring and treating wounds
CN211460840U (en) Portable direct current electric field medical dressing
Korzeniewska et al. Electroceutical Devices in Wounded Skin Treatment
CN207838032U (en) A kind of transcutaneous electrical nerve stimulation far infrared application device
CN206995404U (en) Gel dressing pastes

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination