CN110664801A - 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物 - Google Patents

用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物 Download PDF

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Publication number
CN110664801A
CN110664801A CN201910903770.XA CN201910903770A CN110664801A CN 110664801 A CN110664801 A CN 110664801A CN 201910903770 A CN201910903770 A CN 201910903770A CN 110664801 A CN110664801 A CN 110664801A
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dextromethorphan
quinidine
avp
study
compound
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Chinese (zh)
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J.西弗特
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Aava Neil Pharmaceuticals Ltd By Share Ltd
Avanir Pharmaceuticals Inc
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Aava Neil Pharmaceuticals Ltd By Share Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/49Cinchonan derivatives, e.g. quinine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22Bridged ring systems
    • C07D221/28Morphinans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/485Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201910903770.XA 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物 Pending CN110664801A (zh)

Applications Claiming Priority (35)

Application Number Priority Date Filing Date Title
US201462050170P 2014-09-14 2014-09-14
US62/050,170 2014-09-14
US201462061451P 2014-10-08 2014-10-08
US62/061,451 2014-10-08
US201462063122P 2014-10-13 2014-10-13
US62/063,122 2014-10-13
US201462063861P 2014-10-14 2014-10-14
US62/063,861 2014-10-14
US201462068742P 2014-10-26 2014-10-26
US62/068,742 2014-10-26
US201562111053P 2015-02-02 2015-02-02
US62/111,053 2015-02-02
US201562111590P 2015-02-03 2015-02-03
US62/111,590 2015-02-03
US201562128446P 2015-03-04 2015-03-04
US62/128,446 2015-03-04
US201562162140P 2015-05-15 2015-05-15
US62/162,140 2015-05-15
US201562165535P 2015-05-22 2015-05-22
US62/165,535 2015-05-22
US201562169997P 2015-06-02 2015-06-02
US62/169,997 2015-06-02
US201562180026P 2015-06-15 2015-06-15
US62/180,026 2015-06-15
US201562193347P 2015-07-16 2015-07-16
US62/193,347 2015-07-16
US201562205061P 2015-08-14 2015-08-14
US62/205,061 2015-08-14
US201562216636P 2015-09-10 2015-09-10
US62/216,636 2015-09-10
US201562217142P 2015-09-11 2015-09-11
US201562217470P 2015-09-11 2015-09-11
US62/217,142 2015-09-11
US62/217,470 2015-09-11
CN201580049454.0A CN107072990A (zh) 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物

Related Parent Applications (1)

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CN202311175974.9A Pending CN117427077A (zh) 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物
CN201580049454.0A Pending CN107072990A (zh) 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物
CN201910903770.XA Pending CN110664801A (zh) 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物

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CN201580049454.0A Pending CN107072990A (zh) 2014-09-14 2015-09-14 用于治疗痴呆中的激越行为的包含右美沙芬化合物和奎尼丁的药物组合物

Country Status (15)

Country Link
US (3) US20190111047A1 (enExample)
EP (4) EP4166141A1 (enExample)
JP (4) JP2017531033A (enExample)
KR (1) KR20170052684A (enExample)
CN (3) CN117427077A (enExample)
AU (3) AU2015314710A1 (enExample)
CA (1) CA2960031A1 (enExample)
IL (2) IL250786A0 (enExample)
MX (3) MX2017003066A (enExample)
MY (1) MY198587A (enExample)
PH (1) PH12017500444A1 (enExample)
RU (1) RU2017112747A (enExample)
SG (2) SG10201901242PA (enExample)
TW (3) TW201613591A (enExample)
WO (1) WO2016040930A1 (enExample)

Cited By (4)

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CN113209042A (zh) * 2021-05-28 2021-08-06 珠海润都制药股份有限公司 一种氢溴酸右美沙芬硫酸奎尼丁胶囊及其制备方法
CN115322150A (zh) * 2021-05-11 2022-11-11 深圳信立泰药业股份有限公司 氘代右美沙芬氢溴酸盐的固体及其制备方法和医药用途
CN115734787A (zh) * 2020-04-27 2023-03-03 阿瓦尼尔制药股份有限公司 治疗与阿尔茨海默氏病相关的激越的方法
CN116459255A (zh) * 2022-01-19 2023-07-21 深圳信立泰药业股份有限公司 氘代右美沙芬与安非他酮联合在制备ad激越的药物中的用途

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CN114712357A (zh) * 2019-01-07 2022-07-08 安泰赛普生物风投二代有限责任公司 用于治疗抑郁症的右美沙芬和安非他酮的组合
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WO2022228363A1 (zh) * 2021-04-27 2022-11-03 杭州剂泰医药科技有限责任公司 一种组合物的医药用途
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115734787A (zh) * 2020-04-27 2023-03-03 阿瓦尼尔制药股份有限公司 治疗与阿尔茨海默氏病相关的激越的方法
CN115322150A (zh) * 2021-05-11 2022-11-11 深圳信立泰药业股份有限公司 氘代右美沙芬氢溴酸盐的固体及其制备方法和医药用途
CN115322150B (zh) * 2021-05-11 2024-05-28 深圳信立泰药业股份有限公司 氘代右美沙芬氢溴酸盐的固体及其制备方法和医药用途
CN113209042A (zh) * 2021-05-28 2021-08-06 珠海润都制药股份有限公司 一种氢溴酸右美沙芬硫酸奎尼丁胶囊及其制备方法
CN116459255A (zh) * 2022-01-19 2023-07-21 深圳信立泰药业股份有限公司 氘代右美沙芬与安非他酮联合在制备ad激越的药物中的用途

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IL250786A0 (en) 2017-04-30
EP4166141A1 (en) 2023-04-19
RU2017112747A (ru) 2018-10-15
AU2020289733A1 (en) 2021-01-21
CN107072990A (zh) 2017-08-18
EP3932907A2 (en) 2022-01-05
MY198587A (en) 2023-09-06
TWI869633B (zh) 2025-01-11
RU2020116666A (ru) 2020-07-31
MX2022008181A (es) 2022-08-10
EP3708168A3 (en) 2020-12-09
MX2021010696A (es) 2021-10-01
TW202231278A (zh) 2022-08-16
KR20170052684A (ko) 2017-05-12
AU2022283671B2 (en) 2025-03-20
PH12017500444A1 (en) 2017-07-31
RU2017112747A3 (enExample) 2019-04-29
WO2016040930A1 (en) 2016-03-17
EP3708168A2 (en) 2020-09-16
US20200289499A1 (en) 2020-09-17
AU2015314710A1 (en) 2017-04-20
SG11201701645WA (en) 2017-04-27
US20190111047A1 (en) 2019-04-18
CN117427077A (zh) 2024-01-23
IL274742A (en) 2020-07-30
MX2017003066A (es) 2017-09-12
SG10201901242PA (en) 2019-03-28
AU2022283671A1 (en) 2023-02-02
EP3193872A4 (en) 2018-02-28
JP2017531033A (ja) 2017-10-19
CA2960031A1 (en) 2016-03-17
JP2023105265A (ja) 2023-07-28
TW202106301A (zh) 2021-02-16
US20240082237A1 (en) 2024-03-14
JP2020019818A (ja) 2020-02-06
TW201613591A (en) 2016-04-16
EP3193872A1 (en) 2017-07-26
JP2021080300A (ja) 2021-05-27
JP7360409B2 (ja) 2023-10-12
EP3932907A3 (en) 2022-03-30

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