CN110663839A - Plant essential oil feed additive for preventing and treating rabbit coccidiosis and preparation method thereof - Google Patents
Plant essential oil feed additive for preventing and treating rabbit coccidiosis and preparation method thereof Download PDFInfo
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- CN110663839A CN110663839A CN201911068431.0A CN201911068431A CN110663839A CN 110663839 A CN110663839 A CN 110663839A CN 201911068431 A CN201911068431 A CN 201911068431A CN 110663839 A CN110663839 A CN 110663839A
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- coccidiosis
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/50—Feeding-stuffs specially adapted for particular animals for rodents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Abstract
The invention relates to a plant essential oil feed additive for preventing and treating rabbit coccidiosis and a preparation method thereof, wherein the feed additive comprises the following ingredients in parts by weight: 3-8% of thyme oil, 2-9% of garlic oil, 3-10% of eucalyptus oil and a carrier: 5-20% of emulsifier and 60-90% of water or silicon dioxide. The production method comprises the following steps: 1) mixing liquid thyme oil, garlic oil and eucalyptus oil at a certain ratio, and mixing; 2) adding an emulsifier into the mixture obtained in the step 1), and fully homogenizing and emulsifying to obtain a water-soluble mixture; 3) adding water into the mixture obtained in the step 2) for dilution to obtain a liquid preparation, and adding silicon dioxide into the mixture obtained in the step 2) for adsorption dilution to obtain a powdery preparation; 4) and (6) packaging. The technical effect is that the composition can effectively prevent and treat hepatic coccidiosis, intestinal coccidiosis and mixed coccidiosis of rabbits, the killing rate of coccidiosis can reach more than 95%, and the composition is simple to take, has obvious curative effect and quick response, and is a safe and efficient parasite expelling product for rabbits.
Description
(I) technical field
The invention relates to a feed additive for preventing and treating rabbit coccidiosis, in particular to a feed additive containing plant essential oil for preventing and treating rabbit coccidiosis, which is divided into two dosage forms of liquid and powder.
(II) background of the invention
The rabbit coccidiosis is a protozoon which is the most serious in meat rabbit parasitic diseases, the disease death rate of the rabbit by the coccidiosis can reach 40-80%, and the cost for the anti-coccidiosis drug in China is hundreds of millions yuan each year. According to the different coccidiosis species and parasitic parts, the coccidiosis can be divided into two types, namely hepatic coccidiosis and intestinal coccidiosis, but mixed infection is the most common. There are 16 kinds of rabbit coccidia recorded in the literature, and more than 12 kinds of rabbit coccidia are investigated in various places of China, except that the rabbit eimeria coccidia parasitizes in intrahepatic bile duct epithelial cells to cause liver type coccidiosis, and the rest of rabbit eimeria coccidia parasitizes in intestinal duct epithelial cells to cause intestinal type coccidiosis. The coccidiosis is generally mixed infection, has great harm to rabbits, is particularly serious to young rabbits before and after weaning, can sometimes cause the death of the rabbits in large quantities, and is a great threat to the rabbit industry.
Although scholars at home and abroad have a certain progress on the research of the rabbit coccidian vaccine, a plurality of problems still exist, and the popularization and the application are difficult in a short term. Chemical medicine prevention and treatment are still the main clinical. By far, the primary means of controlling coccidiosis still relies on chemical control of anticoccidial agents. Because coccidian resistant drugs, such as diclazuril, clopyralid and the like, are used for a long time, the serious problem that the coccidian has drug resistance to the drugs is inevitable, and any coccidian resistant drug sold in the market at present can cause the drug resistance of the coccidia after being used for a certain time. Therefore, the search for a drug which is not suitable for generating drug resistance to coccidia becomes the first problem of people in current coccidia prevention and treatment. In recent years, a plurality of researches on the prevention and treatment of rabbit coccidiosis by using Chinese herbal medicines are carried out. Compared with chemical drug treatment, the Chinese herbal medicine has the advantages of difficult generation of drug resistance, small toxic and side effects, capability of promoting the growth of organisms and the like in the prevention and treatment of the disease, but the traditional Chinese medicine composition for the rabbit coccidiosis is various in types, mostly in a research phase, different in treatment effect and few in practical and wide application. Most of the traditional Chinese herbal medicine anticoccidial drugs are powder, although the powder is easy to process and store and convenient to use, and can be used as a therapeutic drug or a preventive drug when being mixed into feed, the dosage is large and generally accounts for 1% -5% of the feed. The treatment dosage is usually high and needs to be continuously taken for a plurality of days; although the prevention dosage is low, the feed is mixed into the feed for long-term continuous taking, and the cost is higher.
Disclosure of the invention
The invention aims to solve the problems that: overcomes the defects of the prior art, and provides a compound essential oil additive which has reasonable formula, simple preparation and obvious effect and can effectively treat the coccidiosis of the meat rabbits and a preparation method thereof.
The invention also aims to solve the technical problems that: provides a plant essential oil formula for preventing and treating coccidiosis of rabbits.
In order to solve the technical problems, the invention adopts the technical scheme that: the plant essential oil feed additive for preventing and treating rabbit coccidiosis is characterized by being prepared from the following raw materials in parts by weight: every 1000g of the composition comprises 3-8% of thyme oil, 2-9% of garlic oil, 3-10% of eucalyptus oil and a carrier: 5-20% of emulsifier and 60-90% of water or silicon dioxide.
Further, the optimal raw materials of the plant essential oil feed additive comprise the following components in parts by weight: in 1000g, thyme oil 5.5%, garlic oil 4.7%, eucalyptus oil 6.3%, carrier: emulsifier 10%, water or silicon dioxide 73.5%.
Furthermore, the plant essential oil feed additive has two dosage forms, namely a liquid dosage form and a powder dosage form.
Furthermore, the liquid preparation of the plant essential oil feed additive is dissolved in water, can be put into water to be taken by drinking water, and the dosage of the additive is 100mL and is put into 300L of water.
Furthermore, the plant essential oil feed additive powder formulation can be mixed into rabbit feed for administration, and is taken 0.2-0.5g per day.
The invention also aims to solve the technical problems that: provides a preparation method of the plant essential oil additive for rabbits.
In order to solve the technical problems, the invention adopts the technical scheme that: a preparation method of a plant essential oil feed additive for preventing and treating rabbit coccidiosis comprises the following steps:
1) mixing liquid thyme oil, garlic oil and eucalyptus oil at a certain ratio, and mixing;
2) adding an emulsifier into the mixture obtained in the step 1), and fully homogenizing and emulsifying to obtain a water-soluble mixture;
3) adding water into the mixture obtained in the step 2) for dilution to obtain a liquid preparation, and adding silicon dioxide into the mixture obtained in the step 2) for adsorption dilution to obtain a powdery preparation;
4) packaging: filling the liquid preparation, wherein the packaging specification is 100 mL/bottle; the powder formulation is packaged, and the packaging specification is 1 kg/bag.
The invention has the advantages and positive effects that:
1) the feed additive for preventing and treating rabbit coccidiosis provided by the invention is a safe, efficient and drug residue-free green feed additive which is prepared by selecting a natural plant extract compatibility formula by technical personnel according to the rabbit breeding experience for years and according to the modern traditional Chinese medicine theory and utilizing a synergistic effect, performing quantitative and semi-quantitative detection on active ingredients in the natural plant extract compatibility formula by scientific compatibility and applying modern technological means, and is clinically verified to have exact curative effect.
2) The plant essential oil additive provided by the invention can effectively prevent and treat rabbit liver coccidiosis, intestinal coccidiosis and mixed coccidiosis, and the killing rate of coccidiosis can reach more than 95%; also has obvious treatment effect on secondary escherichia coli infection and rotavirus infection caused by rabbit coccidiosis. And has the advantages of simple administration, obvious and lasting curative effect, quick absorption, quick response, strong effect, no irritation, safety and reliability. Can overcome the defects that coccidian drugs damage the intestinal health and cause drug residue in the intestinal tract, and solves the problem of drug resistance of western drugs caused by excessive use of western drugs for preventing and treating rabbit coccidiosis for rabbit breeding personnel.
3) The pharmacological action of the raw materials of the invention is as follows:
safe and efficient plant extract products have become the main development direction of alternative drug additives, but plant extract animal repellent products are rare.
Thyme oil extracted from Thymus vulgaris has activity on the outer layer of intestinal epithelial cells, and can accelerate the renewal rate of intestinal epithelial cells, reduce infection of pathogens on the intestinal epithelial cells, and enhance the digestion and absorption capacity of nutrients; the garlic oil has strong anthelmintic and anti-inflammatory effects, and can inhibit proliferation of parasite oocyst spores, reduce damage to gastrointestinal tract cells, and prevent liver injury caused by parasites. The eucalyptus oil extracted from folium Eucalypti Globueli has strong antibacterial and anthelmintic effects. The plant essential oils are matched and cooperate to play a role, wherein the effective components of polyphenols can play the roles of killing insects, expelling toxin, invigorating yang, stopping dysentery and astringing to stop bleeding, and the normal ion balance of cells is damaged by destroying cell membranes of the coccidia to influence the transportation of ions, combining with the ions in the coccidia to form a complex, so that the coccidia is killed due to the metabolic disturbance. Can quickly kill coccidian and solve bloody stool symptoms.
(IV) detailed description of the preferred embodiments
The present invention is further illustrated by the following specific examples, which are intended to be illustrative, not limiting and are not intended to limit the scope of the invention.
Example 1:
a plant essential oil feed additive for preventing and treating rabbit coccidiosis comprises the following raw materials in parts by weight: thyme oil 5.5%, garlic oil 4.7%, eucalyptus oil 6.3%, carrier: emulsifier 10% and water 73.5%. The preparation method comprises the following steps:
1) compounding liquid thyme oil, garlic oil and eucalyptus oil according to the above steps, and mixing uniformly;
2) adding an emulsifier into the mixture obtained in the step 1), and fully homogenizing and emulsifying to obtain a water-soluble mixture;
3) adding water into the mixture obtained in the step 2) for dilution to obtain a liquid preparation;
4) directly filling to obtain the finished product, wherein the packaging specification is 100 mL/bottle.
Example 2:
a plant essential oil feed additive for preventing and treating rabbit coccidiosis comprises the following raw materials in parts by weight: thyme oil 3%, garlic oil 2%, eucalyptus oil 3%, carrier: 5% of emulsifier and 87% of water. The preparation method comprises the following steps:
1) compounding liquid thyme oil, garlic oil and eucalyptus oil according to the above steps, and mixing uniformly;
2) adding an emulsifier into the mixture obtained in the step 1), and fully homogenizing and emulsifying to obtain a water-soluble mixture;
3) adding water into the mixture obtained in the step 2) for dilution to obtain a liquid preparation;
4) directly filling to obtain the finished product, wherein the packaging specification is 100 mL/bottle.
Example 3:
a plant essential oil feed additive for preventing and treating rabbit coccidiosis comprises the following raw materials in parts by weight: thyme oil 8%, garlic oil 9%, eucalyptus oil 10%, carrier: 10% of emulsifier and 63% of silicon dioxide. The preparation method comprises the following steps:
1) compounding liquid thyme oil, garlic oil and eucalyptus oil according to the above steps, and mixing uniformly;
2) adding an emulsifier into the mixture obtained in the step 1), and fully homogenizing and emulsifying to obtain a water-soluble mixture;
3) adding silicon dioxide in the step 2) to carry out adsorption and dilution to obtain a powdery preparation;
4) packaging with a specification of 1 kg/bag.
And (3) clinical trials:
1) 1600 rabbits were bred in a certain farm in Jinan, Shandong province, and the following symptoms appeared at 2 months of age: anorexia, depression, lying down, and growth retardation; the rabbit coccidiosis is identified as the rabbit coccidiosis due to the increase of eye and nose secretion, the rise of body temperature, abdominal distension, tympanites, diarrhea and frequent defecation. The liquid additive of the embodiment 1 is taken and put into water for direct feeding for treatment by timely adopting the liquid additive, 200L of water is taken in each bottle, and 5 days is a treatment course. After the medicine is taken for 10 days, the food consumption is increased, the spirit is restored to normal, no oocyst is detected in the excrement, 1536 patients are finally cured, 64 patients die, the cure rate is 96.0%, and no relapse occurs.
2) In a certain rabbit farm in Chongqing, 3 thousands of rabbits are stored, 2000 thousands of rabbits are attacked, and the intestinal coccidiosis infection is confirmed by a caesarean section. 1 thousand of these products were used as prepared in example 3. The feed is added into feed according to the dosage of 0.5g per dose, and the treatment lasts for 5 days. The symptoms are obviously relieved on the next day of medication, and except severe cases, a large group of patients are cured on the fifth day. The cure rate reaches 95.7 percent. In addition, 1 thousand sulfa drug sulfadimidine is used, the treatment lasts for 7 days, the effect is achieved on the third day, the large group is cured on the seventh day, and the cure rate is 83.2%.
The experiment proves that the curative effect of the product prepared in the example 2 is obviously superior to that of the chemical medicine for treating rabbit coccidiosis in the market.
Claims (6)
1. The plant essential oil feed additive for preventing and treating rabbit coccidiosis is characterized in that the feed additive comprises the following ingredients in parts by weight per 1000 g:
raw materials: thyme oil: 3 to 8 percent of the total weight of the mixture,
2 to 9 percent of garlic oil,
3 to 10 percent of eucalyptus oil,
carrier: emulsifier: 5 to 20 percent of the total weight of the mixture,
water or silica: 60 to 90 percent.
2. The plant essential oil feed additive for preventing and treating rabbit coccidiosis according to claim 1, is characterized in that the optimal raw materials in parts by weight are as follows: in 1000g, thyme oil 5.5%, garlic oil 4.7%, eucalyptus oil 6.3%, carrier: emulsifier 10%, water or silicon dioxide 73.5%.
3. The plant essential oil feed additive for controlling rabbit coccidiosis according to any one of claims 1 and 2, wherein the preparation is divided into a liquid preparation and a powder preparation.
4. The plant essential oil feed additive for preventing and treating rabbit coccidiosis as claimed in any one of claims 1 and 2, wherein the liquid formulation is dissolved in water and can be administered by drinking water after being added into water, and the dosage is 100mL of the additive into 300L of water; the powder can be mixed with rabbit feed for administration, and is administered 0.2-0.5g per day.
5. The plant essential oil feed additive for preventing and treating rabbit coccidiosis according to any one of claims 1 and 2, wherein the preparation method comprises the following steps:
1) mixing liquid thyme oil, garlic oil and eucalyptus oil at a certain ratio, and mixing;
2) adding an emulsifier into the mixture obtained in the step 1), and fully homogenizing and emulsifying to obtain a water-soluble mixture;
3) adding water into the mixture obtained in the step 2) for dilution to obtain a liquid preparation, and adding silicon dioxide into the mixture obtained in the step 2) for adsorption dilution to obtain a powdery preparation;
4) packaging: filling the liquid preparation, wherein the packaging specification is 100 mL/bottle; the powder formulation is packaged, and the packaging specification is 1 kg/bag.
6. The feed additive according to any one of claims 1 to 5 is used for repelling insects in rabbits in production, is effective in preventing and treating hepatic coccidiosis, intestinal coccidiosis and mixed coccidiosis in rabbits, has preventive and therapeutic effects, and can be used as an insect repellent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911068431.0A CN110663839A (en) | 2019-11-04 | 2019-11-04 | Plant essential oil feed additive for preventing and treating rabbit coccidiosis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911068431.0A CN110663839A (en) | 2019-11-04 | 2019-11-04 | Plant essential oil feed additive for preventing and treating rabbit coccidiosis and preparation method thereof |
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| CN110663839A true CN110663839A (en) | 2020-01-10 |
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| CN201911068431.0A Pending CN110663839A (en) | 2019-11-04 | 2019-11-04 | Plant essential oil feed additive for preventing and treating rabbit coccidiosis and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040241194A1 (en) * | 2001-12-26 | 2004-12-02 | Phytosynthese | Food supplement for animals |
| CN103478507A (en) * | 2013-10-16 | 2014-01-01 | 四川省草原科学研究院 | Antibiotic-free premix for growing rex rabbit |
| CN107279535A (en) * | 2017-07-12 | 2017-10-24 | 江苏隆达生物科技有限公司 | A kind of feed addictive and production method for newborn piglet expelling parasite |
| CN108813202A (en) * | 2018-07-02 | 2018-11-16 | 江苏隆达生物科技有限公司 | A kind of feed addictive and production method for poultry expelling parasite |
-
2019
- 2019-11-04 CN CN201911068431.0A patent/CN110663839A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040241194A1 (en) * | 2001-12-26 | 2004-12-02 | Phytosynthese | Food supplement for animals |
| CN103478507A (en) * | 2013-10-16 | 2014-01-01 | 四川省草原科学研究院 | Antibiotic-free premix for growing rex rabbit |
| CN107279535A (en) * | 2017-07-12 | 2017-10-24 | 江苏隆达生物科技有限公司 | A kind of feed addictive and production method for newborn piglet expelling parasite |
| CN108813202A (en) * | 2018-07-02 | 2018-11-16 | 江苏隆达生物科技有限公司 | A kind of feed addictive and production method for poultry expelling parasite |
Non-Patent Citations (3)
| Title |
|---|
| 冯鹏: "绿色饲料添加剂―大蒜", 《当代畜禽养殖业》 * |
| 胡晖: "新型饲料添加剂大蒜素的应用研究", 《江西饲料》 * |
| 黄雪如等: "大蒜素在家兔颗粒饲料中的应用", 《中国养兔杂志》 * |
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Application publication date: 20200110 |