CN110662575B - 选择性靶向开放血脑屏障的系统和方法 - Google Patents

选择性靶向开放血脑屏障的系统和方法 Download PDF

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CN110662575B
CN110662575B CN201880034342.1A CN201880034342A CN110662575B CN 110662575 B CN110662575 B CN 110662575B CN 201880034342 A CN201880034342 A CN 201880034342A CN 110662575 B CN110662575 B CN 110662575B
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tissue
acoustic response
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CN110662575A (zh
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约阿夫·利维
E·扎迪卡里奥
J·格林菲尔德
R·德皮乔托
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Insightec Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00137—Details of operation mode
    • A61B2017/00154—Details of operation mode pulsed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22005—Effects, e.g. on tissue
    • A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
    • A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A61B2018/00803—Temperature with temperature prediction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/374—NMR or MRI
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/376—Surgical systems with images on a monitor during operation using X-rays, e.g. fluoroscopy
    • A61B2090/3762—Surgical systems with images on a monitor during operation using X-rays, e.g. fluoroscopy using computed tomography systems [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A61N2007/003—Destruction of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0039—Ultrasound therapy using microbubbles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0056—Beam shaping elements
    • A61N2007/0065—Concave transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0095—Beam steering by modifying an excitation signal

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Surgical Instruments (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
CN201880034342.1A 2017-05-23 2018-05-22 选择性靶向开放血脑屏障的系统和方法 Active CN110662575B (zh)

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US201762510023P 2017-05-23 2017-05-23
US62/510,023 2017-05-23
PCT/IB2018/000774 WO2018215839A2 (en) 2017-05-23 2018-05-22 Systems and methods for selective, targeted opening of the blood-brain barrier

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CN110662575B true CN110662575B (zh) 2021-12-28

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EP (1) EP3630262A2 (enExample)
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WO (1) WO2018215839A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11648424B2 (en) 2018-11-28 2023-05-16 Histosonics Inc. Histotripsy systems and methods
US11813485B2 (en) 2020-01-28 2023-11-14 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization
US12318636B2 (en) 2022-10-28 2025-06-03 Histosonics, Inc. Histotripsy systems and methods
US12343568B2 (en) 2020-08-27 2025-07-01 The Regents Of The University Of Michigan Ultrasound transducer with transmit-receive capability for histotripsy
US12446905B2 (en) 2023-04-20 2025-10-21 Histosonics, Inc. Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy

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EP3897391B1 (en) * 2018-12-18 2023-11-15 Insightec Ltd. Echo-based focusing correction
EP3946590B1 (en) * 2019-03-25 2024-05-08 Creaholic S.A. Treatment parameters for acoustic wave stimulation
US20220161013A1 (en) * 2019-04-04 2022-05-26 Northwestern University Improved delivery of drug therapy to the cns by ultrasound-based opening of the blood-brain barrier
US11730452B2 (en) * 2019-04-09 2023-08-22 Insightec Ltd. Systems and methods for regulating microbubbles in ultrasound procedures
JP2022551875A (ja) * 2019-10-11 2022-12-14 インサイテック・リミテッド 集束超音波手技のための事前治療組織増感
DE112021003370T5 (de) 2020-06-22 2023-05-04 Medtronic Navigation, Inc. Schutz von nicht-zielgewebe im laufe von ablationsprozeduren und zugehörige systeme und verfahren
EP3957299A1 (en) * 2020-08-17 2022-02-23 ETH Zurich Localized delivery of diagnostic or therapeutic agents using focused ultrasound
US20240166732A1 (en) 2022-10-24 2024-05-23 West Virginia University Board of Governors on behalf of West Virginia University Methods of improving neurodegenerative disorders by targeted delivery of therapeutic agents
WO2024201441A1 (en) 2023-03-29 2024-10-03 Insightec Ltd. Monitoring and control of histotripsy procedures

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CN101242872A (zh) * 2005-06-21 2008-08-13 因赛泰克有限公司 受控的非线性聚焦超声治疗
CN101698121A (zh) * 2009-10-23 2010-04-28 西安交通大学 促进药物透过血脑屏障的适型超声系统
CN104146730A (zh) * 2014-08-18 2014-11-19 中国人民解放军第三军医大学第二附属医院 医用诊断超声波激励微泡调控双侧血脑屏障通透性的用途
WO2015187968A1 (en) * 2014-06-04 2015-12-10 Sonescence, Inc. Systems and methods for therapeutic agent delivery

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US20070083120A1 (en) 2005-09-22 2007-04-12 Cain Charles A Pulsed cavitational ultrasound therapy
US8057408B2 (en) * 2005-09-22 2011-11-15 The Regents Of The University Of Michigan Pulsed cavitational ultrasound therapy
EP2440292A1 (en) * 2009-06-10 2012-04-18 Insightec Ltd. Acoustic-feedback power control during focused ultrasound delivery
US20130079682A1 (en) * 2011-09-25 2013-03-28 David J. Mischelevich Ultrasound-neuromodulation techniques for control of permeability of the blood-brain barrier
US10322178B2 (en) * 2013-08-09 2019-06-18 The Trustees Of Columbia University In The City Of New York Systems and methods for targeted drug delivery
EP3274049B1 (en) * 2015-03-27 2020-09-02 Profound Medical Inc. Medical instrument for sonicating a set of target volumes
US10076652B2 (en) * 2015-08-10 2018-09-18 Chang Gung University Method for ultrasound-mediated delivery system to monitor molecular penetration

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CN101242872A (zh) * 2005-06-21 2008-08-13 因赛泰克有限公司 受控的非线性聚焦超声治疗
CN101698121A (zh) * 2009-10-23 2010-04-28 西安交通大学 促进药物透过血脑屏障的适型超声系统
WO2015187968A1 (en) * 2014-06-04 2015-12-10 Sonescence, Inc. Systems and methods for therapeutic agent delivery
CN104146730A (zh) * 2014-08-18 2014-11-19 中国人民解放军第三军医大学第二附属医院 医用诊断超声波激励微泡调控双侧血脑屏障通透性的用途

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11648424B2 (en) 2018-11-28 2023-05-16 Histosonics Inc. Histotripsy systems and methods
US11813484B2 (en) 2018-11-28 2023-11-14 Histosonics, Inc. Histotripsy systems and methods
US11980778B2 (en) 2018-11-28 2024-05-14 Histosonics, Inc. Histotripsy systems and methods
US12420118B2 (en) 2018-11-28 2025-09-23 Histosonics, Inc. Histotripsy systems and methods
US12491382B2 (en) 2018-11-28 2025-12-09 Histosonics, Inc. Histotripsy systems and methods
US12491384B2 (en) 2018-11-28 2025-12-09 Histosonics, Inc. Histotripsy systems and methods
US11813485B2 (en) 2020-01-28 2023-11-14 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization
US12343568B2 (en) 2020-08-27 2025-07-01 The Regents Of The University Of Michigan Ultrasound transducer with transmit-receive capability for histotripsy
US12318636B2 (en) 2022-10-28 2025-06-03 Histosonics, Inc. Histotripsy systems and methods
US12390665B1 (en) 2022-10-28 2025-08-19 Histosonics, Inc. Histotripsy systems and methods
US12446905B2 (en) 2023-04-20 2025-10-21 Histosonics, Inc. Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy

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WO2018215839A2 (en) 2018-11-29
CN110662575A (zh) 2020-01-07
WO2018215839A3 (en) 2019-02-07
JP7111744B2 (ja) 2022-08-02
US11918832B2 (en) 2024-03-05
EP3630262A2 (en) 2020-04-08
JP2020520718A (ja) 2020-07-16
US20200139158A1 (en) 2020-05-07

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