CN110658348A - Analysis device, sample introduction system, sample introduction method and medium - Google Patents
Analysis device, sample introduction system, sample introduction method and medium Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0418—Plate elements with several rows of samples
- G01N2035/0422—Plate elements with several rows of samples carried on a linear conveyor
- G01N2035/0424—Two or more linear conveyors
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
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- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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Abstract
An analytical device and its sample introduction system and sample introduction method, the sample introduction system includes the sample shelf used for depositing the sample shelf places the area, advances the sample and advances the mechanism and retrieves and advances the mechanism, the sample shelf places the area including putting into the area used for putting into the sample shelf and retrieving the area used for retrieving the sample shelf, said putting into the area and space proportion that the retrieving area accounts for is adjustable; the sample feeding and pushing mechanism is movably arranged in the sample rack placing area and used for pushing a sample rack to be tested placed in the placing area; the recovery pushing mechanism is movably arranged in the sample rack recovery area and used for pushing the sample rack to be recovered, which enters the recovery area. The sample frame placing area is divided into the placing area and the recovery area by the sample feeding propulsion mechanism, and the volume of the placing area and the capacity of the recovery area are adjustable by the movement of the sample feeding propulsion mechanism.
Description
Technical Field
The invention relates to an analysis device, in particular to a sample introduction system and a sample introduction method of the analysis device.
Background
The analyzing device is used for analyzing body fluid (such as blood, urine or other liquid in vivo) collected from a living body and diagnosing according to the analysis result. In order to improve the detection efficiency, some analysis devices adopt a flow line type sample introduction system to provide samples to be detected for the analysis devices, and the sample introduction system mainly has the functions of inputting, dispatching, transmitting, positioning and recovering the sample rack and has the function of automatically identifying the barcode information of the sample rack and the sample tubes.
At present, the sample introduction system of the analysis device mainly has the following 2 types of modes in the input area and the recovery area.
1. Fixed bin channel type
In patent CN 203929791U, a sample rack conveying system is introduced, which comprises a sample rack conveying track and a sample rack. Wherein, the sample rack conveying track is in a fixed bin channel type. Each bin channel can be used for storing the sample rack to be tested and also can be used for recovering the sample rack after the test is finished. Each channel has sample rack in-position detection and status indication functions. Each channel is provided with a travel switch, whether a sample rack is placed or not is detected, and the state of the position is prompted to a user through an indicator lamp.
This configuration, due to the use of fixed bin lanes as compartments between the sample racks, allows a user to pick and place sample racks individually, which is not suitable for large sample runs. Meanwhile, each bin channel only corresponds to one sample rack, so that when samples are sucked, other sample racks to be detected cannot be stored even if the bin is idle, the occupied space is large, and resource waste is caused.
2. Independent placing area and recovery area
The sample introduction system of some instruments adopts an input area and a recovery area which are mutually independent. When the placing area has a space, a user is supported to place the sample rack at any time. The recovery area is positioned at one side of the placing area, and a user can take a plurality of sample racks from the recovery area in a centralized way.
Disclosure of Invention
The application provides an analytical equipment and sampling system and sampling method thereof, makes the capacity of sample frame input area and recovery area can adjust as required.
According to a first aspect, an embodiment provides a sample introduction system for an analysis device, comprising:
the sample rack placing area comprises a placing area for placing the sample rack and a recovery area for recovering the sample rack, and the space proportion occupied by the placing area and the recovery area is adjustable;
the sample feeding and pushing mechanism is movably arranged in the sample rack placing area; the sample feeding and pushing mechanism is used for pushing a sample rack to be tested, which is placed in the placing area;
and the recovery pushing mechanism is movably arranged in the sample rack recovery area and used for pushing the sample rack to be recovered entering the recovery area.
According to a second aspect, there is provided in an embodiment an analysis apparatus comprising:
an analyzer including a sampling mechanism for aspirating a sample to be tested by the analyzer from a sample container located at a sample aspirating position;
the sample introduction system is used for providing the sample rack to be detected and recovering the sample rack which is completely detected.
According to a third aspect, there is provided in one embodiment a method of sample injection for an analytical device, comprising:
an input area expanding step, which comprises controlling the sample injection propulsion mechanism to move towards one side of the sample frame recovery area when the input area has no sample frame, so as to expand the capacity of the sample frame input area;
a sample rack pushing step, which comprises controlling a sample feeding pushing mechanism to push a sample rack to be detected placed in the placing area so as to provide the sample rack to be detected for the analysis device;
and a recovery area expanding step, which comprises controlling a recovery pushing mechanism to push the sample rack to be recovered to the position of at least one sample rack towards the direction of the sample feeding pushing mechanism when the sample rack to be recovered enters the recovery area, so that the subsequent sample rack to be recovered continues to enter the recovery area.
According to a fourth aspect, an embodiment provides a sample introduction system for an analysis device, comprising:
a memory for storing a program;
a processor for implementing the above method by executing the program stored in the memory.
According to a fifth aspect, an embodiment provides a computer-readable storage medium, characterized by a program, which is executable by a processor to implement the above-mentioned method.
The sample rack placing area comprises the placing area and the recovery area which can be reused, the capacity of the placing area and the capacity of the recovery area are adjustable, the space of the sample rack placing area can be fully utilized, and the capacity of the placing area and the capacity of the recovery area are dynamically adjusted according to actual needs.
Drawings
FIG. 1 is a schematic view of an analysis apparatus;
FIG. 2 is a schematic diagram of a scheduling mechanism in one embodiment;
FIG. 3 is a schematic view of the structure of a finger in one embodiment;
FIG. 4 is a schematic view of a sensor arrangement for moving the guide slot in one embodiment;
FIG. 5 is a flow diagram of a sample introduction system delivering sample racks in one embodiment;
FIG. 6 is a flow diagram illustrating the sample collection system recovering a sample rack in one embodiment;
FIG. 7 is a schematic view of the structural layout of an analysis apparatus in another embodiment;
FIG. 8 is a schematic view showing the structural layout of an analyzing apparatus according to still another embodiment;
FIG. 9 is a schematic illustration of the position of a first sensing element in one embodiment;
FIG. 10 is a schematic view of a sample rack placed in the placement area in one embodiment;
FIG. 11 is a schematic view of a sample pushing mechanism pushing a sample rack according to an embodiment;
fig. 12 is a schematic diagram illustrating the sample rack in the input area being pushed out in one embodiment.
Detailed Description
The present invention will be described in further detail with reference to the following detailed description and accompanying drawings. Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.
Furthermore, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. Also, the various steps or actions in the method descriptions may be transposed or transposed in order, as will be apparent to one of ordinary skill in the art. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.
The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings).
In the embodiment of the invention, the inventor breaks through the thinking mode that the sample rack placing area and the sample rack recycling area are mutually independent and fixed, combines the sample rack placing area and the sample rack recycling area into one area, enables the sample rack to move in the area without obstacles through pulling or pushing of external force, separates the sample rack placing area and the sample rack recycling area through a movable sample feeding and pushing mechanism, and can adjust the space or the volume of the placing area and the sample rack recycling area through the position movement of the sample feeding and pushing mechanism.
The first embodiment is as follows:
referring to fig. 1, the analysis apparatus includes an analyzer 6, a sample introduction system, a memory 8, a processor 9 and an input/output device 7, the analyzer 6 is configured to detect a sample to be detected and output detected data to the processor or store the detected data in the memory, the processor 9 is electrically connected to the analyzer 6, the memory 8 and the input/output device 7, respectively, and the processor 9 is configured to receive detected data output by the analyzer 6, analyze the detected data, obtain an analysis result, or store the detected data and/or the analysis result in the memory 8. The memory 8 is used for storing various test data, analysis results and/or programs, the input and output device 7 is used as an interactive interface between the analysis apparatus and a user, and is used for receiving information input by the user and outputting the information in an acoustic, optical or electrical manner, for example, in a general case, the input and output device 7 includes a display apparatus, and the display apparatus displays the analysis results and/or prompt information obtained by the processor 9 or information such as detection progress to the user in a visual manner.
In the embodiment of the invention, the analysis device can be used for immunoassay and detection of antigen and antibody in a sample, and can also be used for biochemical analysis and detection of various substance components in the sample. The analyzer 6 is different in its constituent parts and detection process according to the purpose of analysis, and in general, the analyzer 6 includes a sampling mechanism 64, a reagent disk 62, a reaction disk 61 and a measuring device 63, a test track 4 is provided at the front end (i.e., the side close to the operator) of the analyzer 6, a sample sucking position 41 is designed on the test track 4, and the sampling mechanism 64 is used for sucking a sample to be detected by the analyzer 6 from a sample container located at the sample sucking position 41 and adding the sucked sample to a reaction container placed on the reaction disk 61. The sampling mechanism 64 is also used to draw reagents from reagent containers placed on the reagent tray 62 and add the reagents to corresponding reaction containers so that the sample and reagents react in the reaction containers. The mechanism for aspirating a sample and the mechanism for aspirating a reagent may be different mechanisms or may be the same mechanism. The measuring device 63 measures the reacted sample.
The sample introduction system is usually designed beside the analyzer 6 for providing the analyzer 6 with sample holders to be tested and for retrieving the completed sample holders. The sample injection system comprises a sample rack placing area 1, a buffer area 2, a scheduling mechanism 3, a sample injection pushing mechanism M1, a recovery pushing mechanism M3 and a controller (not shown in the figure).
The sample rack placing area 1 is arranged side by side with the analyzer 6 and used for storing the sample rack 15 and providing a sample rack to be detected for the analyzer and recovering the sample rack detected by the analyzer. In the embodiment, the sample rack placing area 1 is provided with a bracket, and lugs at two sides of the sample rack 15 are supported on the bracket and can move along the bracket under the pushing or pulling action of external force. In this embodiment, the sample rack placing area 1 is divided into a sample rack placing area (may be referred to as a placing area for short) 13 and a sample rack recycling area (may be referred to as a recycling area for short) 14 by the sample feeding and pushing mechanism M1, the placing area 13 is used for accommodating a sample rack to be detected, and the recycling area 14 is used for accommodating a sample rack to be recovered after detection. As shown in fig. 1, the specimen-rack storage area 13 and the specimen-rack collection area 14 may be two areas adjoining to each other end to end in the Y direction. The sample rack 15 is movable in the area of the sample rack deposit section 13 or the sample rack collection section 14 by pushing or pulling of an external force. To facilitate the delivery and recovery of the sample rack, in a preferred embodiment, a sample introduction channel 11 is provided at an end of the sample rack deposit area 13 away from the sample rack recovery area 14, and a recovery channel 12 is provided at an end of the sample rack recovery area 14 away from the sample rack deposit area 13. The bracket is provided with an opening facing the analyzer 6 at the sample introduction channel 11, so that the sample rack in the sample introduction channel 11 can be moved out of the sample introduction channel 11 under the pushing or pulling action of an external force to complete the delivery of the sample rack to be detected. Also, the carriage has an opening at the retrieval channel 12 toward the analyzer 6 so that the sample holder can enter the retrieval channel by pushing or pulling of an external force.
The sample introduction advancing mechanism M1 is movably disposed on the sample rack placement area 1, for example, straddling the sample rack placement area 1 along the X direction of the sample rack placement area 1, and since the sample rack placement area 13 and the sample rack recovery area 14 are separated by the sample introduction advancing mechanism M1, when the sample introduction advancing mechanism M1 moves along the Y direction, the area size of the sample rack placement area 13 and the sample rack recovery area 14 is changed, and when the area of the sample rack placement area 13 becomes large, the area of the sample rack recovery area 14 becomes small; when the area of the specimen-rack deposit section 13 becomes small, the area of the specimen-rack collecting section 14 becomes large. When a user needs to put a sample rack to be detected into the input area 13, the sample feeding and pushing mechanism M1 can move towards the recovery channel 12 under the control of a user's manual operation or a controller, so as to reduce the area of the sample rack recovery area 14 to enlarge the area of the input area 13, thereby increasing the capacity of putting the sample rack. The sample feeding and pushing mechanism M1 is further configured to push the sample racks 15 to be tested placed in the placement area 13 toward the sample feeding channel 11, so that the sample racks 15 to be tested enter the sample feeding channel 11 one by one. When the sample feeding and pushing mechanism M1 pushes the sample rack 15 to be tested toward the sample feeding channel 11, the area of the recovery area 14 becomes gradually larger, so that the recovery area 14 can accommodate more sample racks. In order to facilitate the movement of the sample rack in the sample rack placing area, the bracket in the sample rack placing area 1 can be designed to penetrate the placing area to the recovery area, so that the sample rack can slide along the bracket. It can be seen that a multiplexing area exists in the middle of the sample rack placing area through the movement of the sample feeding propulsion mechanism, and the maximum movement stroke of the sample feeding propulsion mechanism is determined based on the number of the sample racks to be detected placed in the placing area and the number of the sample racks to be recovered placed in the recovery area during each movement. In this embodiment, the buffer area 2 is disposed in the same row of the sample rack placing area 1, and the buffer area 2 is adjacent to the sample channel 11. The buffer area 2 is used for temporarily storing sample racks to be tested or sample racks needing automatic retesting, as shown in fig. 1, the buffer area 2 includes a plurality of channels 21 for temporarily storing sample racks, and each channel can be used for placing one sample rack.
The dispatching mechanism 3 is used for transporting the sample rack to the target position, for example, transporting the sample rack in the sample channel 11 to the test track 4, the buffer area 2 or the recovery channel 12, or transporting the sample rack in the buffer area 2 to the test track 4 or the recovery channel 12, or transporting the tested sample rack from the test track 4 to the buffer area 2 or the recovery channel 12.
In the embodiment, as shown in fig. 2 and 3, the dispatching mechanism 3 comprises a guide rail 31 in the Y direction, a moving guide groove 32 perpendicular to the guide rail, a pusher 33 and a corresponding driving motor, wherein the moving guide groove 32 is used for placing a sample rack, and both sides of the sample rack are provided with bell mouth guide structures, and the sample rack can enter in both directions. The moving guide 32 is movable in the Y direction along the guide rail 31 by the driving of a motor. When it is desired to move a sample rack into the moving guide 32, the moving guide 32 is moved along the guide rail 31 and aligned with a path (e.g., the sample path 11 or the buffer path 21) from which the sample rack is desired to be moved, and the finger 33 is extended to pull the sample rack from the storage path into the moving guide 32. When it is necessary to move the sample rack in the moving guide groove 32 out to the target position, the moving guide groove 32 is moved along the guide rail 31 and aligned with the target position, and the finger 33 moves the sample rack in the moving guide groove 32 out to the target position.
As shown in fig. 3, which is a schematic view of finger 33, finger 33 is disposed at the bottom of moving guide 32, finger 33 is movable in X, Y, Z three directions, finger 33 follows when moving guide 32 in the Y direction, and the directions in which finger 33 alone moves have the X direction and the Z direction. Finger 33 includes motor 331, cam 332, and hook 333. The rotating shaft of the cam 332 is fixed with the connecting rod of the hook 333, the motor 331 is used for driving the cam 332 to move, and the hook 333 is driven to move up and down in the Z direction when the cam 332 moves. The hook 333 may be inserted into the bottom of the sample rack after being lifted, and the hook 333 may be separated from the bottom of the sample rack after being lowered. The hook 333 moves the sample rack into the guide groove or out of the guide groove into the passage of the buffer area or the recovery passage by the movement in the X direction.
As shown in FIG. 4, there are 3 reflective sensors on the moving guide, FBDY1, FBDY2 and FBDY3 respectively. Two reflective sensors FBDY1 and FBDY2 are used to monitor the entry and exit of the sample rack into and out of the guide slots, and to monitor whether the sample rack fails to move in or out. The reflective sensor FBDY3 is fixed on the movable guide groove, detects the passage of the buffer area from the side, is mainly used for detecting whether a sample rack exists in the passage of the buffer area, confirms whether the passage is empty before pushing the sample rack on one hand, and detects whether a residual sample rack exists during resetting on the other hand. In this embodiment, the sample injection system further includes a scanner 5 and a scanning pushing mechanism M2, the scanner 5 is disposed near the outlet of the sample injection channel 11, the scanning pushing mechanism M2 is disposed above the sample injection channel 11, when the sample rack is pushed into the sample injection channel 11, the scanning pushing mechanism M2 pushes the sample rack along the X direction, so that the sample rack moves out from the outlet of the sample injection channel 11 and passes through the scanning range of the scanner 5, the scanner 5 identifies the barcode of the sample rack and/or the barcodes of each sample, and the sample rack is pushed into the moving guide slot 32 of the scheduling mechanism 3 by the scanning pushing mechanism M2.
In other embodiments, the sample feeding system may not have the scan pushing mechanism M2, but the sample rack in the sample feeding channel is pulled out and moved to the moving guide slot by the hook 333, and scanning is performed in the process. Or the scanner 5 is moved along the sample introduction channel or the moving guide groove, and the bar codes of the sample holders in the sample introduction channel or the moving guide groove are scanned in the moving process, or the bar codes of the samples in the sample holders are scanned one by one.
The sample introduction system further comprises a front end pushing mechanism M4, which is used for moving the sample rack in the guide groove out to the test track 4, and the front end pushing mechanism M4 is normally located at the retracted position, so as not to obstruct the sample rack recovery of the recovery channel. When the dispatching mechanism 3 aligns the sample rack to be tested with the test track 4, the front-end pushing mechanism extends out to push the sample rack to the sample sucking channel of the test track.
The recovery pushing mechanism M3 is movably disposed at the second end of the sample rack placing region, and is used for pushing the sample rack to be recovered entering the recovery passage in the direction. The recovery pushing mechanism M3 has two positions, i.e., an initial position located outside the recovery path, and an extended position located inside the recovery path, the initial position being located outside the recovery path, and the extended position being located on or inside the recovery path. When the sample rack placing section is free of the sample rack, the recovery pushing mechanism M3 is located at the extended position to define the farthest stroke of movement in the direction of the recovery path. When a sample rack enters the recovery channel, the recovery pushing mechanism M3 moves from the initial position to the extended position, pushes the sample rack in the recovery channel to a plurality of (for example, 3) sample rack positions in the direction of the sample feeding pushing mechanism M1, and then returns to the initial position, so as to empty the recovery channel and make the sample rack continue to enter the recovery channel.
The controller is also used to execute the program in the memory to control the analyzer and the sample injection system, such as controlling the actions of the sample injection advancing mechanism M1, the recovery advancing mechanism M3, the scanning advancing mechanism M2 and the dispatching mechanism 3. In some embodiments, the controller and the processor may be separated into two separate components, or in some embodiments, the controller and the processor may be integrated into one component.
In the embodiment of the invention, the sample rack placing area 1 comprises a placing area 13 and a recovery area 14, the placing area 13 is used for accommodating a sample rack to be detected, the recovery area 14 is used for accommodating a sample rack to be recovered after detection is finished, the space proportion occupied by the placing area and the recovery area in the sample rack placing area 1 is adjustable, and when more sample racks to be detected need to be accommodated, the capacity of the placing area can be increased; when more sample racks to be recovered need to be accommodated, the capacity of the recovery area can be increased. Therefore, the space of the sample rack placing area can be fully utilized, and the capacities of the placing area and the recovery area can be dynamically adjusted in real time according to actual requirements.
Referring to fig. 5, the process of delivering the sample rack by the sample injection system includes the following steps:
and step 51, initializing a sample injection system. In this step, the controller controls the sample feeding and pushing mechanism M1 to move (back for short) toward the recovery channel, and controls the recovery and pushing mechanism M3 to move to the extended position to shield the recovery channel, so as to prevent the sample feeding and pushing mechanism M1 from occupying the recovery channel. When the sample feeding and pushing mechanism M1 retreats and touches the recovery and pushing mechanism M3, the controller controls the sample feeding and pushing mechanism M1 to stop moving, at this time, the sample feeding and pushing mechanism M1 retreats to the farthest position, and the capacity of the feeding area also reaches the maximum. The user can put the sample frame to be detected in the putting-in area, and after the putting-in area is finished, the 'operation' key can be started, and the controller receives an 'operation' instruction.
And step 52, injecting samples. The controller controls the sample feeding and pushing mechanism M1 to move towards the direction of the sample feeding channel (forward for short), and pushes the sample rack to be detected at the foremost end one by one to the sample feeding channel by pushing the sample rack to be detected at the position of one sample rack each time.
Step 53, the sample rack is moved to the dispatching mechanism. The controller controls the scanning pushing mechanism M2 to push the sample rack in the sample feeding channel into the moving guide slot 32 of the dispatching mechanism 3, and scans the sample rack in the pushing process.
The sample rack is transported to the target location, step 54. The target position is determined on a case-by-case basis, and in general, the target position is the test track 4. However, when the test track 4 is occupied or fails, the buffer 2 is determined as a target position, and the dispatching mechanism 3 transports the sample rack to the temporary storage passage of the buffer 2. When the sample rack scanning fails, the target position is the recovery lane, and therefore, the scheduling mechanism 3 directly transports the sample rack to the recovery lane. Taking the target position as the test track 4 as an example, in this case, the dispatching mechanism 3 transports the sample rack to the entrance of the test track 4, the controller controls the front end pushing mechanism M4 to extend out and move towards the test track 4 along the X direction, the sample rack in the moving guide groove is pushed to the sample sucking channel of the test track 4 during the moving process, the test track 4 conveys the sample to be tested on the sample rack to the sample sucking position 41, and the sample sucking operation is performed by the analyzer so as to detect and analyze the sample.
And step 55, judging whether the sample rack in the placing area is pushed, if so, executing step 56, otherwise, executing steps 52-54 in a circulating manner.
And 56, controlling the sample feeding and pushing mechanism M1 to move towards the direction of the recovery channel until the sample feeding and pushing mechanism M3 touches or the recovered sample rack stops. The newly formed placing area can accept that the user places the sample rack to be detected again.
When the target position of the sample rack transported by the dispatching mechanism 3 is the buffer area 2, before the step 54, it is further required to determine whether there is a free channel in the buffer area 2, if there is a free channel in the buffer area 2, the step 54 is executed, the dispatching mechanism 3 transports the sample rack to the channel of the buffer area 2, if there is no free channel in the buffer area 2, the dispatching mechanism 3 suspends the transportation first, and further prompts: the buffer has no free channel, please wait a little.
Referring to fig. 6, the process of recovering the sample rack by the sample injection system includes the following steps:
at step 61, the controller controls the recycling pushing mechanism M3 to retract to the initial position to expose the recycling path.
And 63, the controller controls the recovery pushing mechanism M3 to move towards the extending position, and the sample rack of the recovery channel is pushed towards the sample feeding pushing mechanism M1 by at least one sample rack position in the moving process to leave the recovery channel, so that the recovery channel can continuously receive the next sample rack to be recovered.
And step 64, judging whether the sample rack is completely recovered, if so, ending, and otherwise, executing steps 62-63 in a circulating mode. In actual detection, the sample feeding process and the sample recovering process are executed simultaneously, and when a test is started, the number of sample racks to be detected is usually large, the number of sample racks to be recovered is small or even none, and along with the detection, the number of sample racks to be detected is gradually reduced, and the number of sample racks to be recovered is gradually increased. In this embodiment, the sample injection pushing mechanism M1 has two purposes, which not only plays a role of pushing the sample rack to be tested, but also serves as a separation boundary between the input area and the recovery area, and moves through the sample injection pushing mechanism M1, so that the capacities of the input area and the recovery area are adjustable, the area of the input area gradually decreases from large to small after the test of a batch of samples is started, and the area of the recovery area gradually increases from small to large, and the change is matched with the change of the numbers of the sample racks to be tested and the sample racks to be recovered in the test process, so that the whole volume can be smaller under the condition that the capacity requirements of the input area and the recovery area are met, and the miniaturization of the analyzer is facilitated.
In some embodiments, when no sample to be recovered enters the sample rack recovery area beyond the preset time, the controller is further configured to control the sample feeding and pushing mechanism to move to the side of the sample rack recovery area, and control the sample feeding and pushing mechanism to stop moving when the sample feeding and pushing mechanism touches the sample rack to be recovered in the sample rack recovery area.
In some embodiments, the movement of the feeding pushing mechanism M1 and/or the recycling pushing mechanism M3 may be controlled not by the controller, but by hand.
In some embodiments, through the matching design of the scheduling mechanism, the sample rack placing area may not be provided with a dedicated sample feeding channel, and the sample rack recovery area may not be provided with a dedicated recovery channel, for example, the sample feeding propulsion mechanism directly pushes the to-be-recovered sample rack placed in the sample rack placing area to the scheduling mechanism, or the recovery propulsion mechanism directly pushes the to-be-recovered sample rack on the scheduling mechanism to the recovery area.
In some embodiments, the layout shown in fig. 7 may be adopted, in which the buffer area 2 is disposed at the front end of the instrument, and the sample rack placement area 1 is disposed at the rear end of the instrument. Alternatively, the buffer area 2 and the sample rack placement area 1 may be arranged side by side in the layout shown in fig. 8. The test track 4 may be located at the front end of the analyzer 6, closer to the user, or at the rear end of the analyzer 6, further from the user.
Example two:
when the controller controls the movement or stop of the sample feeding propulsion mechanism M1 and the recovery propulsion mechanism M3, the controller can calculate the movement distance of the sample feeding propulsion mechanism M1 and the recovery propulsion mechanism M3 by counting the operation steps of the stepping motor, and control the start and stop of the sample feeding propulsion mechanism M1 and the recovery propulsion mechanism M3 according to the movement distance and the direction.
In order to detect the movement state of the sample feeding mechanism M1 and control the movement and stop of the sample feeding mechanism M1 based on the detection result, in the present embodiment, a first detection component is added on the basis of the first embodiment, please refer to fig. 9-12, and the first detection component includes a first initial position sensor 101, a limit position sensor 102, a backward-to-position sensor 103, and a forward-to-position sensor 104.
The first home position sensor 101 is disposed at a position close to the recovery path, and detects whether the sample introduction advancing mechanism M1 has moved to the position of the farthest stroke in the direction of the recovery path when there is no sample rack in the sample rack placement area. When the sample feeding mechanism M1 retreats to the farthest stroke, the first home position sensor 101 is triggered (e.g., shielded), the first home position sensor 101 outputs a detection signal to the controller, and the controller controls the sample feeding mechanism M1 to stop retreating based on the detection signal.
The limit sensor 102 is disposed near the sample feeding channel, and is used for detecting whether the sample feeding mechanism M1 moves to the direction of the sample feeding channel to the position of the farthest stroke when there is no sample rack in the placement area, for example, the position of the farthest stroke may make the distance between the sample feeding mechanism M1 and the sample feeding channel baffle 111 smaller than the width of one sample rack, when the sample feeding mechanism M1 reaches the position, the limit sensor 102 is triggered, and outputs a detection signal to the controller, and the controller controls the sample feeding mechanism M1 to stop advancing based on the detection signal.
The forward-to-position sensor 104 is disposed on the sample feeding pushing mechanism M1, and is configured to detect whether the sample rack to be tested in the loading area abuts against a front sample rack to be tested when the sample feeding pushing mechanism M1 pushes the sample rack to be tested in the loading area in the direction of the sample feeding channel. Referring to fig. 10 and 11, the sample feeding and pushing mechanism M1 includes a motor M11, a first moving member M12 and a pushing member M13, the motor M11 is connected to the controller, the motor M11 is used to drive the first moving member M12 to move or stop at the sample rack placing area according to the control signal output by the controller, and the pushing member M13 is disposed on the first moving member M12 and extends above the bottom supporting surface 131 of the sample rack so as to be able to contact the sample rack 15 placed at the sample placing area. The first moving member includes a first slider M121, a second slider M122 and a spring M123 sliding along the guide rail 132, two ends of the spring M123 are respectively fixed on the first slider M121 and the second slider M122, and in a normal state, the first slider M121 and the second slider M122 are abutted together due to the elastic force of the spring M123. The forward-to-position sensor 104 is arranged on the first sliding block or the second sliding block, a blocking piece 105 for triggering the forward-to-position sensor is correspondingly arranged on the second sliding block or the first sliding block, the forward-to-position sensor 104 can be an optical coupler, for example, when the first sliding block M121 and the second sliding block M122 abut against each other, the blocking piece 105 is inserted into the forward-to-position sensor 104 to block light, and the forward-to-position sensor 104 is prevented from being triggered. When the catch 105 and the advance-to-position sensor 104 are separated, the advance-to-position sensor 104 is triggered and outputs an electrical signal to the controller. The motor M11 is provided on the first slider M121 near the input area, and the pushing member M13 is provided on the second slider M122.
The back-to-place sensor 103 is arranged on the sample feeding and pushing mechanism M1 and is used for detecting whether the sample feeding and pushing mechanism M1 touches the sample rack to be recovered in the process of moving towards the direction of the recovery channel when the sample rack to be recovered is placed in the recovery area. The backward in-place sensor 103 is arranged on the motor M11 and used for detecting whether the motor is locked, and when the motor M11 is locked, the backward in-place sensor sends a trigger signal to the controller.
Also, in order to detect the movement state of the recovery propulsion mechanism M3 and control the movement and stop of the recovery propulsion mechanism M3 based on the detection result, the present embodiment adds a second detection means for detecting or defining whether the recovery propulsion mechanism is in the initial position or the extended position, to the first embodiment. Referring to fig. 10-12, in an embodiment, the second detecting component may include a second initial position sensor 201 and an extended position sensor 202, when the recycling pushing mechanism M3 moves to the initial position, the second initial position sensor 201 is triggered to output a trigger signal to the controller, and the controller controls the recycling pushing mechanism M3 to stop moving. When the recovery propulsion mechanism M3 moves to the extended position, the extended position sensor 202 is triggered to output a trigger signal to the controller, and the controller controls the recovery propulsion mechanism M3 to stop moving.
In other embodiments, the second detecting member may also adopt other manners, such as a limit structure, so that the recycling pushing mechanism M3 has two stop positions on its moving stroke.
In the idle state, the recovery pushing mechanism M3 is in the extended position, and the sample feeding pushing mechanism M1 is back to the initial position and is in close contact with the recovery pushing mechanism M3, so that the largest space is left for the user to insert the largest sample rack. As shown in fig. 10. Or when a user needs to put a sample rack to be tested in the putting area, an instruction is input, the controller controls the motor M11 of the sample feeding propulsion mechanism M1 to rotate reversely and move towards the direction of the recovery channel, and simultaneously controls the recovery propulsion mechanism M3 to move to the extending position, when the sample feeding propulsion mechanism M1 retreats and touches the recovery propulsion mechanism M3, the movement of the sample feeding propulsion mechanism M1 is hindered, the motor M11 on the sample feeding propulsion mechanism is locked, the retreating in-place sensor 103 is triggered, a trigger signal is input to the controller, and the controller controls the sample feeding propulsion mechanism M1 to stop moving.
When a user places a sample rack to be tested in the placing area and applies for testing, the sample feeding and pushing mechanism M1 moves towards the placing area so as to provide the sample rack to be tested for the analyzer. As shown in FIG. 11, the controller controls the motor M11 to rotate forward, the motor M11 drives the first slide M121 to move toward the direction of the sample feeding channel 11, the spring M123 connecting the first slide M121 and the second slide M122 is stretched, and the spring M123 pulls the second slide M122 to follow the movement of the first slide M121. In the moving process, after the pushing component M13 of the sample feeding pushing mechanism M1 contacts the sample rack, the sample rack is pushed to move towards the direction of the sample feeding channel, the foremost sample rack is pushed into the sample feeding channel, one side of the sample feeding channel is provided with a baffle for blocking the sample rack from continuing to advance, when the sample rack abuts against the baffle of the sample feeding channel, the sample rack stops moving forwards, the sample rack behind the sample rack is also stopped and stops moving, and the pushing component M13 drives the second sliding block M122 to stop moving. However, at this time, the first slide block M121 is still moving towards the sample feeding channel under the driving of the motor M11, so that the distance between the first slide block M121 and the second slide block M122 is gradually increased, when the distance is large enough to separate the blocking piece 105 from the forward-to-position sensor 104, the forward-to-position sensor 104 is triggered to output an electric signal to the controller, and the controller controls the motor to stop rotating, thereby completing the pushing action. In the preferred embodiment, the controller pushes back a certain micro-step after controlling motor M11 to stop rotating forward, releasing the pre-pressure of the spring.
After the sample rack enters the sample feeding channel, the controller can send an instruction to the scheduling mechanism, and after the scheduling mechanism finishes the current action, the moving guide groove 32 is aligned to the sample feeding channel. When the movable guide slot 32 is aligned with the sample injection channel, the scan pushing mechanism M2 can push the sample rack into the movable guide slot 32. During the advancing process, the sample rack moves and scans, and the controller determines the next target position to which the sample rack is to be delivered according to the state of the front-end sample absorption area after scanning.
When all the sample racks in the placing area are pushed, as shown in fig. 12, the limit position sensor 102 is triggered at this time, a trigger signal is output to the controller, the controller performs an and operation according to signals output by the limit position sensor 102 and the forward position sensor 104, if the trigger signal of the forward position sensor 104 is not received, it is determined that the sample rack to be detected is pushed empty, and the sample feeding and pushing mechanism M1 is controlled to stop moving. Or after the recovery pushing mechanism M3 finishes the pushing action of the sample rack in the recovery area, controlling the sample feeding pushing mechanism M1 to move towards the recovery area. When the sample advancing mechanism M1 moves backwards, if the back-to-position sensor 103 is triggered, which indicates that the sample advancing mechanism M1 has contacted the sample rack in the recovery area at this time, the sample advancing mechanism M1 is controlled to stop moving immediately.
In the embodiment, the automatic control of the sample feeding and pushing mechanism and the recovery and pushing mechanism can be realized by a detector mode, so that the sample rack placing area and the sample rack recovery area can automatically adjust the volume of the sample rack placing area and the sample rack recovery area according to the detection requirement.
Those skilled in the art will appreciate that all or part of the functions of the various methods in the above embodiments may be implemented by hardware, or may be implemented by computer programs. When all or part of the functions of the above embodiments are implemented by a computer program, the program may be stored in a computer-readable storage medium, and the storage medium may include: a read only memory, a random access memory, a magnetic disk, an optical disk, a hard disk, etc., and the program is executed by a computer to realize the above functions. For example, the program may be stored in a memory of the device, and when the program in the memory is executed by the processor, all or part of the functions described above may be implemented. In addition, when all or part of the functions in the above embodiments are implemented by a computer program, the program may be stored in a storage medium such as a server, another computer, a magnetic disk, an optical disk, a flash disk, or a removable hard disk, and may be downloaded or copied to a memory of a local device, or may be version-updated in a system of the local device, and when the program in the memory is executed by a processor, all or part of the functions in the above embodiments may be implemented.
The present invention has been described in terms of specific examples, which are provided to aid understanding of the invention and are not intended to be limiting. For a person skilled in the art to which the invention pertains, several simple deductions, modifications or substitutions may be made according to the idea of the invention.
Claims (19)
1. A sample introduction system for an analytical device, comprising:
the sample rack placing area (1) comprises a placing area (13) for placing the sample rack and a recovery area (14) for recovering the sample rack, and the space proportion occupied by the placing area and the recovery area is adjustable;
the sample feeding and pushing mechanism (M1) is movably arranged in the sample rack placing area and used for pushing the sample rack to be tested placed in the placing area;
a retrieval pushing mechanism (M3) movably disposed at the retrieval area for pushing the sample rack into the retrieval area.
2. The sample introduction system according to claim 1, wherein the sample introduction propulsion mechanism is disposed in the sample rack placement area and divides the sample rack placement area into the placement area and the recovery area, and when the sample introduction propulsion mechanism moves to a side where the placement area is located, a proportion of space occupied by the placement area decreases, and a proportion of space occupied by the recovery area increases; when the sample feeding and pushing mechanism moves to one side where the recovery area is located, the space proportion occupied by the placing area is increased, and the space proportion occupied by the recovery area is reduced.
3. The sample introduction system according to claim 2, further comprising a controller for controlling the movement of the sample introduction propulsion mechanism and/or the recovery propulsion mechanism within respective movement strokes, wherein the movement strokes of the sample introduction propulsion mechanism are determined based on the number of sample racks to be tested placed in the deposit area and/or the number of sample racks to be recovered placed in the recovery area.
4. The sample injection system of claim 3, wherein the controller is further configured to control the sample injection propulsion mechanism to move to the side of the retrieval area when the sample rack is absent from the input area to expand the capacity of the input area, and/or to control the retrieval propulsion mechanism to propel the sample rack to be retrieved by the width of at least one sample rack to the side of the input area when the sample rack to be retrieved enters the retrieval area.
5. The sample introduction system according to claim 3, wherein the controller is further configured to control the sample introduction propulsion mechanism to move to a side of the recovery area when no sample to be recovered enters the recovery area for more than a preset time; and when the sample feeding and pushing mechanism touches the sample rack to be recovered in the recovery area, the sample feeding and pushing mechanism is controlled to stop moving.
6. The sample introduction system according to claim 4 or 5, further comprising a first detection component, wherein the first detection component is connected to the controller, and is configured to detect a motion state of the sample introduction propulsion mechanism and output a detection signal to the controller, and the controller controls the sample introduction propulsion mechanism to move or stop according to the detection signal.
7. The sample introduction system according to claim 6, wherein the input zone is provided with a sample introduction channel (11) at its end remote from the recovery zone, and the recovery zone is provided with a recovery channel (12) at its end remote from the input zone; the first detection part comprises a first initial position sensor (101), a limit position sensor (102), a retreating in-place sensor (103) and an advancing in-place sensor (104), the first initial position sensor is arranged at a position close to the recovery channel and used for detecting whether the sample feeding propulsion mechanism moves to the direction of the recovery channel to the position of the farthest stroke when the sample rack placing area has no sample rack, the limit position sensor is arranged at a position close to the sample feeding channel and used for detecting whether the sample feeding propulsion mechanism moves to the position of the farthest stroke in the direction of the sample feeding channel when the sample rack placing area has no sample rack, the advancing in-place sensor is arranged on the sample feeding propulsion mechanism and used for detecting whether the sample rack to be detected in the sample feeding area is abutted to the sample rack to be detected in front when the sample feeding propulsion mechanism propels the sample rack to be detected in the sample feeding channel, the retreating in-place sensor is arranged on the sample feeding, the sample feeding and pushing mechanism is used for detecting whether the sample feeding and pushing mechanism touches the sample rack to be recovered in the direction moving process of the recovery channel when the sample rack to be recovered is placed in the recovery area.
8. The sample introduction system according to claim 7, wherein the sample introduction propulsion mechanism (M1) comprises a motor (M11), a first moving member (M12) and a pushing member (M13), the motor is connected with the controller, the motor is used for driving the first moving member to move or stop at the sample rack placing area according to a control signal output by the controller, the pushing member is arranged on the first moving member and extends out of the bottom supporting surface of the sample rack, the first moving member comprises a first slide block (M121), a second slide block (M122) and a spring (M123), two ends of the spring are respectively fixed on the first slide block and the second slide block, the forward position sensor is arranged on the first slide block or the second slide block, a baffle plate for triggering the forward position sensor is correspondingly arranged on the second slide block or the first slide block, the backward position sensor is arranged on the motor, the motor is used for detecting whether the motor is locked.
9. The sample injection system of claim 4 or 5, wherein the recovery propulsion mechanism is switched between an initial position and an extended position under control of the controller, the initial position being outside the recovery channel and the extended position being inside the recovery channel.
10. The sample introduction system according to claim 9, further comprising a second detection component for detecting or defining whether the recovery propulsion mechanism is in the initial position or the extended position.
11. The sample introduction system according to claim 1, further comprising a dispatching mechanism (3) for transporting the sample rack.
12. The sample introduction system according to claim 1, further comprising a buffer area (2) for temporarily storing the sample rack to be tested or the sample rack requiring automatic retesting.
13. An analysis apparatus, comprising:
an analyzer (6) comprising a sampling mechanism for aspirating a sample to be analyzed from a sample container located at a sample aspirating position;
the sample introduction system according to any of claims 1 to 11, for providing sample racks to be tested and recovering the completed test sample racks.
14. A sample introduction method for an analysis apparatus, comprising:
an input area expanding step, which comprises controlling the sample feeding propulsion mechanism to move to one side of the recovery area when the input area has no sample rack, so as to expand the capacity of the input area;
a sample rack pushing step, which comprises controlling a sample feeding pushing mechanism to push a sample rack to be detected placed in the placing area so as to provide the sample rack to be detected for the analysis device;
and a recovery area expanding step, which comprises controlling a recovery pushing mechanism to push the sample rack to be recovered to the position of at least one sample rack towards the direction of the sample feeding pushing mechanism when the sample rack to be recovered enters the recovery area, so that the subsequent sample rack to be recovered continues to enter the recovery area.
15. The method of claim 13, wherein the deposit zone expanding step further comprises, when the retrieval zone is free of sample racks to be retrieved:
controlling the recovery propulsion mechanism to move from the initial position to the extending position so as to shield the recovery channel when the sampling propulsion mechanism moves to one side of the recovery area;
controlling the sample feeding propulsion mechanism to stop moving when touching the recovery propulsion mechanism;
controlling the recovery propulsion mechanism to move from the extension position to the initial position after the sample feeding propulsion mechanism stops moving;
when the sample rack is to be recovered in the recovery area, the placing area expanding step further comprises the following steps:
when the sample feeding and pushing mechanism touches the sample rack to be recovered in the process of moving to one side of the recovery area, the sample feeding and pushing mechanism is controlled to stop moving.
16. The method of claim 13, wherein the put-in zone expanding step further comprises: when no sample to be recovered enters the recovery area after the preset time, controlling the sample feeding propulsion mechanism to move to one side of the recovery area; and when the sample feeding and pushing mechanism touches the sample rack to be recovered in the recovery area, the sample feeding and pushing mechanism is controlled to stop moving.
17. The method of claim 13, wherein the reclamation area expansion step further comprises: when the sample rack to be recovered is touched and the sample rack still needs to be recovered in the recovery channel, the sample feeding and pushing mechanism is controlled to move towards the placing area.
18. A sample introduction system for an analytical device, comprising:
a memory for storing a program;
a processor for implementing the method of any one of claims 13-16 by executing a program stored by the memory.
19. A computer-readable storage medium, comprising a program executable by a processor to implement the method of any one of claims 13-16.
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| WO2022160153A1 (en) * | 2021-01-28 | 2022-08-04 | 贝克曼库尔特实验系统（苏州）有限公司 | Sample rack manipulation device, testing system and testing method and computer-readable medium |
| WO2022160152A1 (en) * | 2021-01-28 | 2022-08-04 | 贝克曼库尔特实验系统（苏州）有限公司 | Sample rack recovery method and manipulation device, detection system, and computer-readable medium |
| WO2022160151A1 (en) * | 2021-01-28 | 2022-08-04 | 贝克曼库尔特实验系统（苏州）有限公司 | Conveying device, sample rack manipulation apparatus and automatic test system |
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| TG01 | Patent term adjustment | ||
| TG01 | Patent term adjustment |