CN110646553B - Centrifugal filling column loading machine - Google Patents
Centrifugal filling column loading machine Download PDFInfo
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- CN110646553B CN110646553B CN201911069163.4A CN201911069163A CN110646553B CN 110646553 B CN110646553 B CN 110646553B CN 201911069163 A CN201911069163 A CN 201911069163A CN 110646553 B CN110646553 B CN 110646553B
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- 230000005526 G1 to G0 transition Effects 0.000 claims abstract description 54
- 239000000463 material Substances 0.000 claims abstract description 37
- 238000012856 packing Methods 0.000 claims abstract description 23
- 230000002093 peripheral effect Effects 0.000 claims abstract description 19
- 230000000903 blocking effect Effects 0.000 claims description 18
- 238000007789 sealing Methods 0.000 claims description 6
- 230000005540 biological transmission Effects 0.000 claims description 5
- 239000013013 elastic material Substances 0.000 claims description 3
- 238000003825 pressing Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 239000011491 glass wool Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000003365 glass fiber Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000005489 elastic deformation Effects 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000002808 molecular sieve Substances 0.000 description 2
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 2
- 238000004804 winding Methods 0.000 description 2
- 238000005452 bending Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/56—Packing methods or coating methods
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/56—Packing methods or coating methods
- G01N2030/562—Packing methods or coating methods packing
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The embodiment of the invention discloses a centrifugal filling column packing machine, which comprises a centrifugal component, a pushing component and a feeding component, wherein the pushing component and the feeding component are arranged on the centrifugal component; the centrifugal component is a conical body capable of rotating, a guide groove is formed in the peripheral wall of the centrifugal component at a position close to the vertex of the centrifugal component, and a fixing groove is formed between the guide groove and the bottom surface of the centrifugal component along the direction of a generatrix; the material passing opening of the guide groove is larger than the material feeding opening, and the material feeding opening is communicated with the fixed groove; the pushing component is positioned between the vertex and the guide groove and comprises a pushing piece and a driving piece, wherein the pushing piece moves between the vertex and the guide groove; the charging member is disposed on the centrifuge member proximate the apex, and the charging member includes an inlet and an annular outlet. The stationary phase is pressed into the filling column through centrifugal force, so that the problems of poor repeatability and high labor cost are solved, the processing repeatability is improved, and the production efficiency is improved.
Description
Technical Field
The invention relates to the field of chromatography, in particular to a centrifugal packed column packing machine.
Background
The existing column filling method is to plug glass wool on one end of the column, then connect with a mechanical vacuum pump to pump air, and install a funnel on the other end, slowly fill the dry stationary phase into the column, and lightly knock the wall of the column with a stick until the column is full, and plug glass wool on the end of the column slightly leaves a little space.
The chromatographic column is required to be knocked by the wood rod continuously in the mode, the column loading process generally lasts for a period of time, the column loading person can be tired very and can not guarantee the uniformity of knocking force, the stationary phase can be destroyed when the knocking force is overlarge, the filling column is not loaded in the excessively small time, the repeatability is poor, meanwhile, only one filling column can be loaded at the same time in the mode, the manufacturing efficiency is low, and the labor cost is high.
Disclosure of Invention
The invention aims to solve the problems of poor repeatability, low manufacturing efficiency and high labor cost in the prior art. The invention provides a centrifugal filling column filling machine which presses a stationary phase into a filling column through centrifugal force, and the problems of poor repeatability and high labor cost are solved by avoiding manual operation; secondly, the invention can prepare a plurality of columns simultaneously at the same time and has uniform force application, thereby improving the repeatability and the production efficiency.
In order to solve the technical problems, the embodiment of the invention discloses a centrifugal filling column packing machine, which comprises a centrifugal component, a pushing component and a feeding component, wherein the pushing component and the feeding component are arranged on the centrifugal component; the centrifugal component is conical, and rotates around a straight line where the height of the conical is positioned as a rotation shaft, a guide groove is formed in the peripheral wall of the centrifugal component at a position close to the vertex of the centrifugal component, a fixing groove is formed in the side face of the centrifugal component along the direction of a bus, and the fixing groove is located between the guide groove and the bottom face of the centrifugal component; the guide groove comprises a material passing opening and a feeding opening, the material passing opening is larger than the feeding opening, and the feeding opening is communicated with the fixed groove; the fixed groove is used for placing the filling column, and when the filling column is placed in the fixed groove, the pipe orifice of the filling column is connected and communicated with the charging hole; the pushing component is arranged on the peripheral wall and positioned between the vertex and the guide groove, and comprises a pushing piece and a driving piece in transmission connection with the pushing piece; wherein the pushing member moves between the apex and the guide groove, and the pushing member is used for pressing the stationary phase into the feed inlet; the feeding part is arranged on the centrifugal part at a position close to the vertex, and comprises an inlet and an annular outlet, wherein the annular outlet is positioned above the feeding opening, and the stationary phase flowing out of the annular outlet is annular when falling on the peripheral wall.
By adopting the technical scheme, the stationary phase is added to the material passing opening of the guide groove through the material feeding part, then the stationary phase is pressed into the filling column through the guide groove by the extrusion of the material pushing part and the centrifugal action of the centrifugal part, the stationary phase is compacted in the filling column by the continuous operation of the centrifugal part, and the filling column is rolled into a winding column according to the use requirement after being compacted, so that the filling column is suitable for filling the granular stationary phase such as a molecular sieve, a GDX series and the like. The stationary phase is uniformly filled by the manpower knocking avoided by the scheme, and the problem of insufficient repeatability is solved by centrifugal force compaction.
According to another embodiment of the present invention, a centrifugal packed column packing machine is disclosed, wherein the pushing member comprises an annular elastic member of which the circumference can be changed, and moves between a position near the apex and the guide groove by stretching and shrinking itself; when the annular elastic piece is in an extension state, the annular elastic piece is abutted against the guide groove and elastically deformed to extrude the inner wall surface of the material opening; when the annular elastic piece is in a contracted state, the annular elastic piece is close to the vertex, and the circumference and the internal formed circular area of the annular elastic piece are smaller than those of the annular elastic piece in an expanded state; the annular outlet is located above a position between the guide groove and the annular elastic member in a contracted state.
By adopting the technical scheme, the annular elastic piece stretches, the centrifugal part is conical, the circumference of the annular elastic piece is enlarged at the moment, namely the circumference of the annular elastic piece is enlarged in the width direction, so that the annular elastic piece moves downwards in the vertical direction until the material passing hole, the annular elastic piece continuously stretches to extrude and deform at the material passing hole, the annular elastic piece is fully extruded with the material passing hole to completely press the stationary phase into the guide groove, the material feeding hole of the guide groove is connected and communicated with the filling column, the stationary phase enters the filling column under the action of centrifugal force, the effect of pushing the stationary phase into the guide groove is achieved, and the stationary phase can be extruded into the guide groove completely through elastic deformation.
According to another embodiment of the invention, the centrifugal filling column loading machine disclosed by the embodiment of the invention is characterized in that the guide groove is an annular groove and surrounds the outer peripheral wall of the centrifugal part.
By adopting the technical scheme, the guide grooves are propped against each other and are annularly arranged to form a ring, namely, the guide grooves are circumferentially arranged to form a ring around the outer peripheral wall of the cone, at the moment, the stationary phase flowing out of the annular outlet uniformly falls above the guide grooves and is pushed in by the pushing piece, so that the filling columns of a plurality of filling columns can be filled simultaneously.
According to another embodiment of the invention, a centrifugal packed column packing machine is disclosed in the embodiment of the invention, wherein the material passing opening of the guide groove extends in a direction perpendicular to the peripheral wall to form a blocking part.
By adopting the technical scheme, the blocking part can block the annular outlet from being centrifugally thrown out before the stationary phase flows out of the stationary phase and enters the guide groove.
According to another specific embodiment of the invention, the centrifugal filling column loading machine disclosed by the embodiment of the invention is provided with a fixing piece on a fixing groove.
By adopting the technical scheme, the filling column can be prevented from being centrifugally thrown out by the fixing piece.
According to another specific embodiment of the invention, the bottom end of the fixed groove is provided with the blocking piece, the blocking piece is made of elastic materials, and when the filling column is placed in the fixed groove, the blocking piece is in interference fit with a port at the bottom of the filling column.
By adopting the technical scheme, the operation of inserting glass wool into a port to block the port in a filling link is omitted, the glass wool can be reused, and the production efficiency is further improved.
According to another embodiment of the invention, a centrifugal packed column packing machine is disclosed in the embodiment of the invention, wherein the inlet forms a containing cavity, and a sealing cover is arranged on the containing cavity.
By adopting the technical scheme, the probability of exposing the stationary phase in the air can be reduced by covering the holding cavity of the inlet with the sealing cover, and the stationary phase is prevented from being deactivated.
According to another embodiment of the invention, the centrifugal filling column loading machine disclosed by the embodiment of the invention has the advantages that the included angle between the bus bar of the centrifugal component and the bottom surface is larger than 0 degrees and smaller than or equal to 45 degrees.
By adopting the technical scheme, the stationary phase can be kept to be at most half of the force component direction of the centrifugal force to the pipe wall of the filling column, so that the stationary phase is ensured to move towards the bottom end of the filling column under the action of the centrifugal force.
Drawings
FIG. 1 is a schematic diagram of a centrifugal packed column packing machine in one implementation of an embodiment of the invention;
FIG. 2 is a schematic diagram of a centrifugal packed column machine according to another embodiment of the invention;
FIG. 3 is an enlarged partial view of the centrifugal components of a centrifugal packed column packing machine in accordance with an embodiment of the invention;
fig. 4 is a schematic view of the annular outlet structure of a centrifugal packed column packing machine in accordance with an embodiment of the present invention.
100: A centrifugal component; 110: an outer peripheral wall; 120: a vertex; 130: a guide groove; 131: a material passing opening; 132: a feed inlet; 133: a blocking portion; 140: a fixing groove; 141: a fixing member; 142: a blocking member; 150: a rotation shaft;
200: a pushing component; 210: a propulsion member; 220: a driving member;
300: a charging member; 310: an inlet; 311: a receiving chamber; 320: annular outlet
10: And filling the column.
Detailed Description
Further advantages and effects of the present invention will become apparent to those skilled in the art from the disclosure of the present specification, by describing the embodiments of the present invention with specific examples. While the description of the invention will be described in connection with the preferred embodiments, it is not intended to limit the inventive features to the implementation. Rather, the purpose of the invention described in connection with the embodiments is to cover other alternatives or modifications, which may be extended by the claims based on the invention. The following description contains many specific details for the purpose of providing a thorough understanding of the present invention. The invention may be practiced without these specific details. Furthermore, some specific details are omitted from the description in order to avoid obscuring the invention. It should be noted that, without conflict, the embodiments of the present invention and features of the embodiments may be combined with each other.
It should be noted that in this specification, like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.
In the description of the present embodiment, it should be noted that the azimuth or positional relationship indicated by the terms "upper", "lower", "inner", "bottom", etc. are based on the azimuth or positional relationship shown in the drawings, or the azimuth or positional relationship in which the inventive product is conventionally put in use, are merely for convenience of describing the present invention and simplifying the description, and are not indicative or implying that the apparatus or element to be referred to must have a specific azimuth, be configured and operated in a specific azimuth, and therefore should not be construed as limiting the present invention.
The terms "first," "second," and the like are used merely to distinguish between descriptions and are not to be construed as indicating or implying relative importance.
In the description of the present embodiment, it should also be noted that, unless explicitly specified and limited otherwise, the terms "disposed," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present embodiment can be understood in a specific case by those of ordinary skill in the art.
For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in further detail below with reference to the accompanying drawings.
To solve the above-mentioned technical problems, an embodiment of the present invention discloses a centrifugal packed column packing machine, as shown in fig. 1, including a centrifugal part 100, a pushing part 200, and a charging part 300, and the pushing part 200 and the charging part 300 are disposed on the centrifugal part 100; wherein the centrifugal member 100 is conical and rotates around a straight line where the height of the cone is located as a rotation axis, the outer peripheral wall 110 of the centrifugal member 100 is provided with a guide groove 130 at a position close to the vertex 120 of the centrifugal member 100, the side surface of the centrifugal member 100 is formed with a fixing groove 140 along the direction of a generatrix, and the fixing groove 140 is located between the guide groove 130 and the bottom surface of the centrifugal member 100; the guide groove 130 comprises a material passing opening 131 and a material feeding opening 132, the material passing opening 131 is larger than the material feeding opening 132, and the material feeding opening 132 is communicated with the fixed groove 140; and, the fixed slot 140 is used for placing the filling column 10, when the filling column 10 is placed in the fixed slot 140, the pipe orifice of the filling column 10 is connected and communicated with the charging port 132; the pushing member 200 is disposed on the peripheral wall 110 and between the apex 120 and the guide groove 130, and the pushing member 200 includes a pushing member 210 and a driving member 220 drivingly connected to the pushing member 210; wherein the pushing member 210 moves between the apex 120 and the guide groove 130, and the pushing member 210 is used to press the stationary phase into the feed inlet 132; the charging member 300 is provided on the centrifugal member 100 at a position near the apex 120, and the charging member 300 includes an inlet 310 and an annular outlet 320, the annular outlet 320 being located above the passing port 131, and the stationary phase flowing out of the annular outlet 320 being annular when falling on the peripheral wall 110.
Specifically, the generatrix is the radius of a sector used for enclosing a cone, and the generatrix direction is the waist line direction. The centrifugal component 100 rotates around its own straight line as a rotation axis, generates a centrifugal force in a horizontal direction, the packed column is placed along a waist line direction, and after the stationary phase (the stationary phase is a core of the packed column 10 forming a chromatographic separation effect, and is mainly powdery or granular packing) enters the packed column 10, the centrifugal force in the horizontal direction is received, and is converted into a component force in a column tube direction under the influence of the inner wall of the packed column, and simultaneously moves toward the column bottom under the influence of gravity. Avoiding the operations of suction and knocking.
When the packed column 10 is placed in the fixed groove 140, the column end of the packed column 10 is inserted into the feed inlet 132 of the guide groove 130, and the stationary phase can directly enter the packed column 10 after entering from the feed inlet 131. The bottom end of the filling column 10 can be inserted into glass wool or can be abutted against the bottom of the fixing groove 140 to form interference fit. The guide groove is provided near the apex 120 of the centrifugal part 100 with the guide groove 130, i.e. at a height in the drawing which leaves the fixing groove 140 with a sufficient length on the waist line for placing the filling column 10, and also gives sufficient space for providing the pushing part 200 and the charging part 300.
The guide groove 130 may be an annular groove as shown in fig. 2, and the material passing opening 131 is an annular opening correspondingly, and a plurality of material feeding openings 132 are arranged on the annular groove. The guide grooves 130 may also be a plurality of grooves as shown in fig. 1, and the fixing grooves 140 and the guide grooves 130 are the same in number and are disposed in one-to-one correspondence. And the fixing groove 140 and the guide groove 130 are provided around the circumference of the centrifugal member 100 in a circle so that the stationary phase of the conical centrifugal member 100 at the same height as the feed gap 131 in the circumference is pushed in. The guide grooves 130 may be concentrated to the feed port 132 through the feed port 131, and the number of the guide grooves 130 and the fixing grooves 140 is smaller as the number of the guide grooves is greater than that of the feed port 131, and the size thereof may be specifically selected according to design requirements by those skilled in the art. The stationary phase flowing out of the annular outlet 320 naturally falls in an annular shape when it falls down on the outer peripheral wall 110, that is, the stationary phase at this time falls around the circumference of the centrifugal member 100 above the guide groove 130 to be pushed further into the packed column 10 by the pushing member 210.
The driving member 220 of the pushing member 200 may be a shaft transmission, a gear transmission, or the like, which are commonly used by those skilled in the art, or may be a transmission manner in which a telescopic rod and a force limiting spring are combined in fig. 1, and the driving member 220 is driven by a power device such as a motor, which is not particularly limited in this embodiment. The push driving piece 220 moves up and down in the belt line direction of the centrifugal part 100. The pushing member 210 may be a piston or a push rod, or may be a ring-shaped pushing member.
Illustrated in fig. 1,2 and 3 are cross-sectional views of a loading element 300, the inlet 310 of the loading element 300 being a single inlet, the stationary phase being split and exiting at an annular outlet 320 after entering. And as shown in fig. 4, the annular outlet 320 is composed of a plurality of holes and is arranged in a ring shape with each other, and since the annular outlet 320 is in a ring shape, the stationary phase is uniformly guided to flow out in a ring shape after reaching the annular outlet 320. For example, in the figure, the stationary phase enters at the inlet 310, the pipe between the inlet 310 and the annular outlet 320 is concentrated, after reaching the annular outlet 320, the stationary phase moves around to the annular outlet 320 in the middle convex position, and the stationary phase flows out uniformly because the cross section of each part of the annular outlet 320 is the same, and the effluent is annular because each part of the cross section is annular after being combined.
When in use, the stationary phase is added to the material passing opening 131 of the guide groove 130 through the material feeding part 300, then the stationary phase is pressed into the filling column 10 through the guide groove 130 by the extrusion of the material pushing part 200 and the centrifugation of the centrifugal part 100, and the stationary phase is compacted in the filling column 10 by the continuous operation of the centrifugal part 100, and the filling column 10 is wound again according to the requirement of use after being compacted, and the winding column is stretched at the bending position, so that the invention is particularly suitable for filling granular stationary phases such as molecular sieves, GDX series and the like.
In a preferred embodiment, pusher member 210 comprises an annular elastic member of variable circumference and is movable between a position adjacent apex 120 and guide slot 130 by stretching and collapsing upon itself; when the annular elastic piece is in an extension state, the annular elastic piece is abutted against the guide groove 130 and elastically deformed to press the inner wall surface of the material opening 131; when the annular elastic member is in the contracted state, the annular elastic member is close to the apex 120, and the circumference and the internal circular area of the annular elastic member are smaller than those of the annular elastic member in the expanded state; the annular outlet 320 is located above a position between the guide groove 130 and the annular elastic member in a contracted state.
Specifically, the annular elastic member surrounds the centrifugal member 100, and since the centrifugal member 100 is conical, the higher the height, the smaller the circumference, the annular elastic member can move up and down by changing the circumference, that is, the driving member 220 pushes the annular elastic member vertically downward from the vertical upper direction along the waist line direction to stretch the annular elastic member, and conversely, pulling the annular elastic member to contract the annular elastic member. When the annular elastic member is in an expanded state and abuts against the guide groove 130, the annular elastic member is elastically deformed to press the inner wall surface of the material inlet 131, and the annular elastic member is contracted to return to the original state.
During the use, through the extension of annular elastic component, because centrifugal part 100 is conical, annular elastic component perimeter grow promptly at the width direction grow this moment, and then make it move down in vertical direction until passing through material mouth 131, continue the extension then annular elastic component extrude and warp at passing through material mouth 131, annular elastic component crowded material mouth presses the stationary phase into guide slot 130 completely, the charge door 132 of guide slot 130 is connected and communicates with filling column 10, the stationary phase gets into filling column 10 under the effect of centrifugal force, the effect of propelling movement stationary phase to guide slot 130 has been played, can extrude the stationary phase through elastic deformation and get into guide slot 130 inside completely again.
In a preferred embodiment, as shown in fig. 2, the guide groove 130 is an annular groove, surrounding the outer peripheral wall 110 of the centrifuge component 100.
Specifically, the number of the guide grooves 130 and the fixing grooves 140 is smaller as the number of the feed holes 131 is larger, and the size and the number thereof can be specifically selected by those skilled in the art according to design requirements, as long as the plurality of guide grooves 130 can be abutted against each other and annularly arranged on the centrifugal member 100. In addition, the fixing groove 140 and the guide groove 130 are disposed around the circumference of the centrifugal member 100 at this time, so that the stationary phase of any position of the conical centrifugal member 100 at the same height as the feed gap 131 in the circumference can be pushed in. Accordingly, the annular outlet 320 need only be annular, eliminating the labor-consuming process of multiple outlets.
In use, the guide grooves 130 are abutted against each other and annularly arranged, that is, annularly arranged around the conical outer peripheral wall 110 in the circumferential direction of the conical centrifugal member 100, and the stationary phase flowing out of the annular outlet 320 uniformly falls over the guide grooves 130 and is pushed in by the pushing member 210, so that the packing of the plurality of packing columns 10 can be performed simultaneously.
In a preferred embodiment, as shown in fig. 2 and 3, the material passing opening 131 of the guide groove 130 is formed with a blocking portion 133 extending in a direction perpendicular to the outer circumferential wall 110.
Specifically, the blocking portion 133 may be L-shaped or straight-plate-shaped.
In use, the blocking portion 133 can block the annular outlet 320 from being spun off before the stationary phase flows out of the guide slot 130.
In a preferred embodiment, as shown in fig. 1 and 2, the fixing groove 140 is provided with a fixing member 141.
Specifically, the fixing member 141 may be a fastening means commonly used in the art, such as a buckle, a strap, or a hinge to be engaged with a lock.
In use, the packing column 10 is prevented from being centrifuged out by the provision of the fixing member 141.
In a preferred embodiment, as shown in fig. 1 and 2, the bottom end of the fixing groove 140 is provided with a blocking member 142, the blocking member 142 being of an elastic material, and the blocking member 142 being interference-fitted with the port of the bottom of the packing column 10 when the packing column 10 is placed in the fixing groove 140.
Specifically, the blocking member 142 may be a soft polymer or glass wool, and after the packed column 10 is inserted into the fixing groove 140, the bottom end of the packed column 10 is aligned with the blocking member 142 to be blocked, so as to facilitate filling of the stationary phase
When the glass fiber filling device is used, the operation that the glass fiber is inserted into the port to block the port in the filling link in the prior art is omitted, the glass fiber filling device can be reused, and the production efficiency is further improved.
In a preferred embodiment, the inlet 310 forms a receiving chamber 311 and a sealing cover is provided on the receiving chamber.
Specifically, the receiving cavity 311 may be an inverted cone shape, and the sealing cover is a cover commonly used by those skilled in the art to cover the receiving cavity 311.
When the stationary phase is used, the sealing cover is covered on the holding cavity of the inlet, so that the probability of exposing the stationary phase in the air can be reduced, and the stationary phase is prevented from being inactivated.
In a preferred embodiment, as shown in fig. 1 and 2, the included angle of the generatrix of the centrifugal component 100 to the bottom surface is greater than 0 ° and less than or equal to 45 °.
When the device is used, the stationary phase can be kept to be at most half of the component force direction of the centrifugal force to be at most towards the pipe wall of the filling column, so that the stationary phase is ensured to move towards the bottom end of the filling column under the action of the centrifugal force.
While the invention has been shown and described with reference to certain preferred embodiments thereof, it will be understood by those skilled in the art that the foregoing is a further detailed description of the invention with reference to specific embodiments, and it is not intended to limit the practice of the invention to those descriptions. Various changes in form and detail may be made therein by those skilled in the art, including a few simple inferences or alternatives, without departing from the spirit and scope of the present invention.
Claims (7)
1. A centrifugal packed column packing machine, which is characterized by comprising a centrifugal component, a pushing component and a feeding component, wherein the pushing component and the feeding component are arranged on the centrifugal component; wherein,
The centrifugal component is conical and rotates around a straight line where the height of the conical is located as a rotation shaft, a guide groove is formed in the peripheral wall of the centrifugal component at a position close to the vertex of the centrifugal component, a fixing groove is formed in the side face of the centrifugal component along the direction of a bus, and the fixing groove is located between the guide groove and the bottom face of the centrifugal component;
The guide groove comprises a material passing opening and a material feeding opening, the material passing opening is larger than the material feeding opening, the material feeding opening is communicated with the fixed groove, the guide groove is an annular groove, and the guide groove surrounds the outer peripheral wall of the centrifugal part; and
The fixed groove is used for placing a filling column, and when the filling column is placed in the fixed groove, the pipe orifice of the filling column is connected and communicated with the charging port;
The pushing component is arranged on the peripheral wall and positioned between the vertex and the guide groove, and comprises a pushing piece and a driving piece in transmission connection with the pushing piece; wherein,
The pushing member moves between the vertex and the guide groove, and the pushing member is used for pressing the stationary phase into the feed inlet;
The pushing member comprises an annular elastic member of which the circumferential size is changeable, and moves between a position near the apex and the guide groove by stretching and shrinking of the pushing member itself;
The feeding component is arranged on the centrifugal component at a position close to the vertex, the feeding component comprises an inlet and an annular outlet, the annular outlet is positioned above the feeding port, and the stationary phase flowing out of the annular outlet is annular when falling on the peripheral wall.
2. The centrifugal packed column packing machine according to claim 1, wherein,
When the annular elastic piece is in an extension state, the annular elastic piece is abutted against the guide groove and elastically deforms to squeeze the inner wall surface of the material passing opening;
When the annular elastic member is in a contracted state, the annular elastic member is close to the vertex, and the circumference and the internal formed circular area of the annular elastic member are smaller than those of the annular elastic member in an expanded state;
the annular outlet is located above a position between the guide groove and the annular elastic member in a contracted state.
3. The centrifugal packed column packing machine according to claim 1, wherein the feed gap of the guide groove is formed with a stopper extending in a direction perpendicular to the outer peripheral wall.
4. The centrifugal packed column packing machine according to claim 1, wherein the fixing groove is provided with a fixing member.
5. The centrifugal packed column packing machine according to claim 1, wherein a blocking member is provided at a bottom end of the fixed groove, the blocking member being an elastic material, and the blocking member is interference-fitted with a port at a bottom of the packed column when the packed column is placed in the fixed groove.
6. The centrifugal packed column packing machine according to claim 1, wherein the inlet forms a receiving chamber and a sealing cover is provided on the receiving chamber.
7. The centrifugal packed column packing machine of claim 1, wherein an included angle of a bus bar of the centrifugal component to the bottom surface is greater than 0 ° and less than or equal to 45 °.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911069163.4A CN110646553B (en) | 2019-11-05 | 2019-11-05 | Centrifugal filling column loading machine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911069163.4A CN110646553B (en) | 2019-11-05 | 2019-11-05 | Centrifugal filling column loading machine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110646553A CN110646553A (en) | 2020-01-03 |
| CN110646553B true CN110646553B (en) | 2024-04-26 |
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Citations (7)
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| US4985143A (en) * | 1988-06-06 | 1991-01-15 | The University Of Maryland | Method for packing chromatographic beds |
| CN103703365A (en) * | 2011-08-05 | 2014-04-02 | 罗伯特·博世有限公司 | Laterally perfused chromatography element |
| CN104034833A (en) * | 2014-06-30 | 2014-09-10 | 厦门大学 | Preparing device and method for nanofiller capillary chromatography microcolumn |
| CN105353060A (en) * | 2015-12-16 | 2016-02-24 | 常州东曦自动化科技有限公司 | Full-automatic liquid Chromatogram column packing machine |
| CN108700561A (en) * | 2016-01-06 | 2018-10-23 | 通用电气医疗集团生物工艺研发股份公司 | Method and apparatus for packing chromatography column assembly |
| CN110302556A (en) * | 2019-07-29 | 2019-10-08 | 古浪县康泰中药材种植专业合作社 | A kind of Chinese medicine percolating extractor |
| CN210953941U (en) * | 2019-11-05 | 2020-07-07 | 兰州东立龙信息技术有限公司 | Automatic column filling machine for packed column |
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2019
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4985143A (en) * | 1988-06-06 | 1991-01-15 | The University Of Maryland | Method for packing chromatographic beds |
| CN103703365A (en) * | 2011-08-05 | 2014-04-02 | 罗伯特·博世有限公司 | Laterally perfused chromatography element |
| CN104034833A (en) * | 2014-06-30 | 2014-09-10 | 厦门大学 | Preparing device and method for nanofiller capillary chromatography microcolumn |
| CN105353060A (en) * | 2015-12-16 | 2016-02-24 | 常州东曦自动化科技有限公司 | Full-automatic liquid Chromatogram column packing machine |
| CN108700561A (en) * | 2016-01-06 | 2018-10-23 | 通用电气医疗集团生物工艺研发股份公司 | Method and apparatus for packing chromatography column assembly |
| CN110302556A (en) * | 2019-07-29 | 2019-10-08 | 古浪县康泰中药材种植专业合作社 | A kind of Chinese medicine percolating extractor |
| CN210953941U (en) * | 2019-11-05 | 2020-07-07 | 兰州东立龙信息技术有限公司 | Automatic column filling machine for packed column |
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| CN110646553A (en) | 2020-01-03 |
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