CN110639124A - Microneedle fixed-point anesthesia device - Google Patents
Microneedle fixed-point anesthesia device Download PDFInfo
- Publication number
- CN110639124A CN110639124A CN201910947149.3A CN201910947149A CN110639124A CN 110639124 A CN110639124 A CN 110639124A CN 201910947149 A CN201910947149 A CN 201910947149A CN 110639124 A CN110639124 A CN 110639124A
- Authority
- CN
- China
- Prior art keywords
- capsule
- micro
- capsule body
- microneedle
- flexible rod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M19/00—Local anaesthesia; Hypothermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a microneedle fixed-point anesthesia device, which comprises: the micro-needle comprises a capsule body and a plurality of micro-needles arranged on the outer surface of the capsule body, wherein a capsule opening is formed in the capsule body, one end of a flexible rod extends into the capsule body through the capsule opening, the end part of the end is passivated, the capsule opening is sealed on the flexible rod, a plurality of storage chambers are arranged on the outer surface of the capsule body, the storage chamber space is formed by wrapping a capsule skin part of the capsule body, each micro-needle is located in each storage chamber, and the micro-needles can be exposed from the storage chambers and distributed on the outer surface of the capsule body when the capsule body is expanded. The device utilizes the utricule and the internal toughness pole of capsule relatively nimble reacing appointed position back, through inside extrusion for the micropin that is located the tibetan that the utricule surface set up takes place the displacement, contacts the target area, thereby carries out the anesthesia of fixing a point, and is relatively nimble anaesthetize appointed region, and is relatively less to the stimulation in anesthesia region, and the anesthesia is comparatively concentrated, and the universality is high.
Description
Technical Field
The invention relates to an anaesthesia device, in particular to a microneedle fixed-point anaesthesia device.
Background
It is generally accepted that anesthesia is a reversible functional inhibition of the central and/or peripheral nervous system, produced by drugs or other means, and this inhibition is characterized primarily by loss of sensation, particularly pain.
Anesthesia means that a patient temporarily loses his or her feeling wholly or locally by medication or other means to perform surgical treatment for the purpose of painlessness. Anesthesiology is a science that applies basic theory, clinical knowledge and technology related to anesthesia to eliminate operation pain of patients, ensure the safety of patients and create good conditions for operations. Nowadays, anesthesiology has become a special independent subject in clinical medicine, mainly including clinical anesthesiology, emergency resuscitation medicine, critical care treatment, pain diagnosis and treatment, and other related medicine and mechanism research, and is a comprehensive subject for researching anesthesia, analgesia, emergency resuscitation and critical medicine. Wherein clinical anesthesia is a major component of modern anesthesiology. In general, a syringe is often used for anesthesia, and in recent years, microneedle anesthesia has been gradually used for the selection of anesthesia, but the region anesthetized by microneedles is limited to a specific region on the body surface, and in particular, a microneedle patch is mainly used. For anesthesia of certain areas, such as the ear canal, oral cavity or intestinal tract, the conventional anesthesia devices have difficulty in controlling the input and range of the anesthetic, and thus a microneedle fixed-point anesthesia device is required. The device utilizes the utricule and the internal toughness pole of utricule relatively nimble arrival appointed position after, through inside extrusion for the micropin that is located the tibetan that the utricule surface set up takes place the displacement, contacts the target area, thereby carries out the anesthesia of fixed point.
Disclosure of Invention
The invention overcomes the defects of the prior art and provides a microneedle fixed-point anesthesia device.
In order to achieve the purpose, the invention adopts the technical scheme that: a microneedle site anesthesia apparatus comprising: the micro-needle balloon comprises a balloon body and a plurality of micro-needles arranged on the outer surface of the balloon body, wherein a balloon opening is formed in the balloon body, one end of a flexible rod extends into the balloon body through the balloon opening, the end part of the end is passivated, the balloon opening is sealed on the flexible rod, a plurality of storerooms are arranged on the outer surface of the balloon body, the storeroom space is formed by wrapping a capsule skin part of the balloon body, each micro-needle is located in the storeroom, and the micro-needles can be exposed from the storeroom and distributed on the outer surface of the balloon body when the balloon body expands.
In a preferred embodiment of the present invention, the plurality of the depots are arranged on the outer surface of the capsule in a stripe or dot pattern.
In a preferred embodiment of the present invention, the chamber is a spiral structure or a ring structure.
In a preferred embodiment of the invention, the storeroom is a fold structure formed by folding a part of the outer surface of the capsule body, and the opening of each fold structure is consistent with the orientation of the capsule opening.
In a preferred embodiment of the present invention, an adhesive is dropped on each of the openings.
In a preferred embodiment of the present invention, when the balloon is not inflated, the microneedles arranged in the folded structure are not in contact with the outside; after the capsule body is expanded, the capsule skin forming the fold structure is flattened, and the micro-needle is exposed on the outer surface of the capsule body.
In a preferred embodiment of the invention, the storeroom is a lifting groove structure, and the microneedles are arranged at the bottom of the lifting groove; when the capsule body is not expanded, the bottom of the lifting groove is recessed into the capsule body; after the balloon body is expanded, the bottom of the lifting groove protrudes to the outer surface of the balloon body.
In a preferred embodiment of the invention, the bag opening is sealed on the flexible rod in a hot melting mode, or a pressurizing collar is arranged on the outer surface of the bag opening so that the bag opening is sealed on the flexible rod.
In a preferred embodiment of the present invention, the flexible rod is provided with a plurality of passages, and two ends of the passages are respectively located at two ends of the flexible rod.
In a preferred embodiment of the invention, the passage is connected with a gas supply device, and a gas pressure regulator is arranged on the gas supply device.
In a preferred embodiment of the present invention, the outer surface of the capsule is uniformly coated with a lubricant.
In a preferred embodiment of the present invention, the farther the balloon is from the end of the flexible rod, the lower the concentration of the drug disposed in the microneedle.
The invention solves the defects in the background technology, and has the following beneficial effects:
(1) the device utilizes the utricule and the internal toughness pole of capsule relatively nimble reacing appointed position back, through inside extrusion for the micropin that is located the tibetan that the utricule surface set up takes place the displacement, contacts the target area, thereby carries out the anesthesia of fixing a point, and is relatively nimble anaesthetize appointed region, and is relatively less to the stimulation in anesthesia region, and the anesthesia region is comparatively concentrated, and the universality is high.
(2) Different from a patch micro-needle, the micro-needle is hidden on the capsule body, the ductility and the flexibility of the capsule body are high, different parts of the human body can be relatively attached, the shaping of the capsule body comprises the relatively fast placement of the micro-needle, and the shaping speed of the anesthesia device is relatively fast.
(3) The passage on the flexible rod is connected with an air (liquid) supply device to convey gas (or liquid) for the capsule body, and the control of the air (liquid) pressure regulator is matched, so that the expansion of the capsule body is controlled in a proper range, and the problem of pain or excessive compression of the biological pipeline when the capsule body is expanded is solved.
(4) The Tibetan chamber is the fold structure, the fold structure is formed by folding utricule surface part bag skin, every the opening of fold structure all with the sack orientation is unanimous, and when the utricule moved in the biological duct under the promotion of toughness pole promptly, the open-ended atress condition makes the opening is difficult to be opened, just so makes the micropin be in the state of being protected.
(5) The number of the micro-needles in the reservoir chamber on the capsule body and the concentration of the drugs in the micro-needles are gradually decreased along with the distance from the end part of the flexible rod, namely, the anesthesia effect of the end part of the flexible rod is strongest, the end part area of the flexible rod is a main body for monitoring, the anesthetized drugs are concentrated at the end part of the flexible rod, the observation and the control of a doctor are relatively facilitated, and the limitation of the anesthesia area is facilitated.
(6) To reduce the friction of the balloon with the area to be anesthetized, the microneedles are prevented from being exposed on the outer surface of the balloon in advance, coming into contact with the non-target site. Therefore, the outer surface of the capsule body is coated with a lubricant or a small amount of adhesive is dripped at the fold structure of the storage chamber, so that the micro-needle is ensured to be contacted with the wall of the biological tube only after the capsule body is expanded and to be always stored in the storage chamber before the expansion.
(7) The capsule body is distributed with the storerooms, the storerooms can be selected according to needed anesthesia positions and ranges, the storerooms are in spiral, annular, dot matrix and the like, and the capsule body can be used for different situations needing anesthesia.
Drawings
The invention is further explained below with reference to the figures and examples;
FIG. 1 is a perspective block diagram of a preferred embodiment of the present invention;
FIG. 2 is an enlarged schematic view of region A of FIG. 1;
FIG. 3 is a schematic view of a cuff portion of a preferred embodiment of the present invention;
FIG. 4 is a schematic view of the end portion of the apparatus of the preferred embodiment of the present invention;
FIG. 5 is a schematic view of the structure of the end portion (balloon portion not shown) of the device of the preferred embodiment of the present invention;
in the figure: 1. a capsule body; 2. a bag mouth; 3. a ductile rod; 4. a pump machine; 5. a storeroom; 6. rounding the ends; 7. air holes; 8. a compression collar; 9. an inner lumen channel.
Detailed Description
The invention will now be described in further detail with reference to the accompanying drawings and examples, which are simplified schematic drawings and illustrate only the basic structure of the invention in a schematic manner, and thus show only the constituents relevant to the invention.
As shown in fig. 1 to 5, a microneedle site anesthesia apparatus includes: utricule 1 and a plurality of micropins of 1 surface settings of utricule, be equipped with a sack mouth 2 on the utricule 1, stretch into utricule 1 with toughness pole 3's one end through sack mouth 2 in, and the tip of this end is through passivation treatment, sack mouth 2 seals on toughness pole 3, 1 surface of utricule is equipped with a plurality of storerooms 5, 5 spaces in the storeroom are formed by the parcel of the capsule skin portion of utricule 1, every micropin all is located storeroom 5, the micropin can be exposed and distribute at the surface of utricule 1 in the storeroom 5 when 1 inflation of utricule.
The anesthetic region according to the present invention is roughly described as the ear canal, the oral cavity, and the intestinal tract region, and the microneedle anesthesia is performed, so that the dose of anesthetic cannot be too much to be applied to the syringe, and the anesthesia generally uses excessive anesthesia, and therefore, the operation position is defined here. The structure and fabrication process of the microneedles are prior art and therefore not specifically described herein. The parts of the capsule 1 and the flexible rod 3 in fig. 1 are omitted because the actual expansion and contraction amount and the length of the device need to be determined according to actual conditions, and the storeroom 5 in the figure is of a folded structure.
Manufacturing of the capsule body 1 and placing of the micro-needle: for the biological pipelines such as the auditory meatus, the oral cavity and the intestinal tract, the pipe diameters of the corresponding capsule bodies 1 are selected, the estimation of the pressure bearing capacity of the pipe walls of the biological pipelines is required to be added during the selection, particularly the anesthesia of a human body, the corresponding practical factors of age, sex and physique are required to be considered, and the expanded capsule bodies 1 are used as pressure standard substances during the test of the bearing capacity of the pipe walls. The surface of the bag body 1 is pressed and stretched to form a hidden area (a storeroom 5), so that the storeroom 5 can be unfolded when the bag body 1 is inflated or water-filled and then expanded. Be equipped with a bag mouth 2 on the utricule 1, a toughness pole 3 stretches into utricule 1 through bag mouth 2 with the one end of toughness pole 3 in, and the tip of this end is the mellow and full structure (the structure after passivation), shown mellow and full end 6 in the figure promptly, and when mellow and full end 6 can guarantee that the tip of toughness pole 3 drives utricule 1 and removes, can not puncture utricule 1, prevents to harm the organism of required anesthesia. The number, size and shape of the compartments 5 can be adjusted as desired during manufacture. After the micro-needle is filled with the anesthetic inside, the micro-needle can be fixed on a substrate, the substrate is cut and then fixed in the storeroom 5, and the capsule body 1 can also be directly stretched, so that the micro-needle can be directly fixed in the region of the storeroom 5. If the storeroom 5 is of a fold structure or a lifting groove structure, a small amount of adhesive can be dripped at the opening of the fold structure or the inlet and outlet of the lifting groove, the main component of the adhesive is normal saline, namely, the water solution is used for filling the gap of the opening or the inlet and outlet, the intermolecular force is enhanced, the storeroom 5 where the anesthetic is located is simply plugged, and the adhesive or the lubricant can be brought into the pipe wall of the biological pipeline by the micro-needle, so that the adhesive and the lubricant on the surface of the capsule body 1 both need to have certain biocompatibility as much as possible. When the Tibetan chamber 5 is selected to be made into a folded structure, the opening of the folded structure needs to point to the bag opening 2, namely when the bag body 1 is pushed by the flexible rod 3 to move in the biological pipeline, the opening is not easy to open due to the stress condition of the opening, so that the micro-needle is in a protected state and is not contacted with the outside.
Release of drug and recovery of capsule 1: through a passage in the flexible rod 3 (the passage comprises a flexible rod 3 inner cavity channel 9 and a plurality of air holes 7 on the flexible rod 3 rod body, the air holes 7 are connected with the inner cavity channel 9 to the inner cavity of the capsule 1, the inner cavity channel 9 is connected with a pump machine 4, gas or liquid is conveyed into the capsule 1 through the pump machine 4, so that the capsule 1 is expanded to a certain degree (namely, the size of the capsule 1 before and after expansion is limited during manufacturing, and simultaneously, a regulating device arranged on the passage has a control effect on the expansion of the capsule), microneedles in a storeroom 5 arranged on the outer surface of the capsule 1 are exposed on the outer surface of the capsule 1 (the fold structure can temporarily lose the fold state due to the flat unfolding of a capsule skin forming the fold structure, the microneedles are exposed on the outer surface of the capsule 1, the bottom of a lifting groove in the lifting groove structure is raised due to the expansion of the capsule 1, and then push the micropin of lift groove structure bottom to utricule 1 external surface), utricule 1 just can make the micropin in some Tibetan regions force to extrude utricule 1 surface taking place by a wide margin bending in the removal process, considering that utricule 1 and biological duct are soft material usually, so need not consider hardly that the medicine in the micropin releases the possibility in advance. The use of adhesives and lubricants can also reduce the exposure of the microneedles in the reservoir 5 to the outer surface of the capsule 1. The micro-needles are arranged on the capsule body 1 as much as possible and are close to the end part of the flexible rod 3, the position of the end part of the flexible rod 3 is easy to detect and perceive, when the end part of the flexible rod 3 is close to the needed anesthesia area, that is, the site-specific anesthesia apparatus reaches a predetermined region, and then, microneedle anesthesia is started, gas or liquid is infused through the pathway, so that the capsule body 1 is in an expanded state and the expanded size is kept constant, after the micro-needle is stuck to one end of the tube wall for a while, stopping pressurizing the gas or liquid in the capsule 1, and pumping the liquid or gas in the capsule 1 by a small amount by using the pump 4, thereby the storeroom 5 on the outer surface of the capsule body 1 is restored to the original sunken state, the micro-needle is also retracted and hidden in the storeroom 5, then the flexible rod 3 is slowly pulled, and the capsule body 1 is slowly withdrawn from the biological pipeline, so that the whole process of anesthesia injection is completed.
In light of the foregoing description of the preferred embodiment of the present invention, it is to be understood that various changes and modifications may be made by one skilled in the art without departing from the spirit and scope of the invention. The technical scope of the present invention is not limited to the content of the specification, and must be determined according to the scope of the claims.
Claims (10)
1. A microneedle site anesthesia apparatus comprising: the micro-needle balloon is characterized in that one end of a flexible rod extends into the balloon body through the balloon opening, the end part of the end is passivated, the balloon opening is sealed on the flexible rod, a plurality of chambers are arranged on the outer surface of the balloon body, the chamber space is formed by wrapping a capsule skin part of the balloon body, each micro-needle is located in the chamber, and the micro-needles can be exposed from the chamber and distributed on the outer surface of the balloon body when the balloon body expands.
2. A microneedle site anesthesia apparatus according to claim 1, characterized in that: the storeroom is of a spiral structure or a ring structure.
3. A microneedle site anesthesia apparatus according to claim 1, characterized in that: the Tibetan chamber is the fold structure, the fold structure is formed by the folding of utricule surface part bag skin, every the opening of fold structure all with the bag mouth orientation is unanimous.
4. A microneedle site anesthesia apparatus according to claim 3, characterized in that: and an adhesive is dripped at each opening.
5. A microneedle site anesthesia apparatus according to claim 3, characterized in that:
when the capsule body is not expanded, the micro-needle arranged in the fold structure is not contacted with the outside;
after the capsule body is expanded, the capsule skin forming the fold structure is flattened, and the micro-needle is exposed on the outer surface of the capsule body.
6. A microneedle site anesthesia apparatus according to claim 1, characterized in that:
the storeroom is of a lifting groove structure, and the microneedles are arranged at the bottom of the lifting groove;
when the capsule body is not expanded, the bottom of the lifting groove is recessed into the capsule body;
after the balloon body is expanded, the bottom of the lifting groove protrudes to the outer surface of the balloon body.
7. A microneedle site anesthesia apparatus according to claim 1, characterized in that: the bag opening is sealed on the flexible rod in a hot melting mode, or a pressurizing lantern ring is arranged on the outer surface of the bag opening to enable the bag opening to be sealed on the flexible rod.
8. A microneedle site anesthesia apparatus according to claim 1, characterized in that: the flexible rod is provided with a plurality of passages, and two ends of each passage are respectively positioned at two ends of the flexible rod.
9. A microneedle site anesthesia apparatus according to claim 8, characterized in that: the passage is connected with an air supply device, and an air pressure regulator is arranged on the air supply device.
10. A microneedle site anesthesia apparatus according to claim 1, characterized in that: and the outer surface of the capsule body is uniformly coated with a lubricant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910947149.3A CN110639124A (en) | 2019-09-29 | 2019-09-29 | Microneedle fixed-point anesthesia device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910947149.3A CN110639124A (en) | 2019-09-29 | 2019-09-29 | Microneedle fixed-point anesthesia device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110639124A true CN110639124A (en) | 2020-01-03 |
Family
ID=68993630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910947149.3A Pending CN110639124A (en) | 2019-09-29 | 2019-09-29 | Microneedle fixed-point anesthesia device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110639124A (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5848991A (en) * | 1990-12-13 | 1998-12-15 | Elan Medical Technologies Limited Athlone, Co. | Intradermal drug delivery device and method for intradermal delivery of drugs |
| US20010020151A1 (en) * | 1996-11-06 | 2001-09-06 | Reed Michael L. | Method and apparatus for drug and gene delivery |
| US20050273075A1 (en) * | 2004-06-08 | 2005-12-08 | Peter Krulevitch | Method for delivering drugs to the adventitia using device having microprojections |
| CN101513550A (en) * | 2002-06-25 | 2009-08-26 | 权圣润 | Rapidly dissolving micro-perforator for drug delivery and other applications |
| US20110046556A1 (en) * | 2009-08-22 | 2011-02-24 | Joseph Wayne Kraft | Rapid Local Anesthesia Injection Cone |
| CN102641549A (en) * | 2011-02-18 | 2012-08-22 | 帕洛阿尔托研究中心公司 | Transmucosal medicine conveying device comprising micro needles and transmucosal medicine conveying method |
| US20140276593A1 (en) * | 2013-03-15 | 2014-09-18 | Boston Scientific Scimed, Inc. | Methods and systems for treatment of a bladder |
| CN106334255A (en) * | 2016-11-14 | 2017-01-18 | 柳桂玉 | The injection administration operation device for anus and intestine surgery |
| US20180264043A1 (en) * | 2017-03-14 | 2018-09-20 | Holding Pen, Llc | Restoration of deteriorated tissue in the face or selected areas of the body with mesenchymal stem cells |
| WO2019136133A1 (en) * | 2018-01-03 | 2019-07-11 | The Trustees Of Columbia University In The City Of New York | Microneedle for local delivery of therapeutic agent |
-
2019
- 2019-09-29 CN CN201910947149.3A patent/CN110639124A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5848991A (en) * | 1990-12-13 | 1998-12-15 | Elan Medical Technologies Limited Athlone, Co. | Intradermal drug delivery device and method for intradermal delivery of drugs |
| US20010020151A1 (en) * | 1996-11-06 | 2001-09-06 | Reed Michael L. | Method and apparatus for drug and gene delivery |
| CN101513550A (en) * | 2002-06-25 | 2009-08-26 | 权圣润 | Rapidly dissolving micro-perforator for drug delivery and other applications |
| US20050273075A1 (en) * | 2004-06-08 | 2005-12-08 | Peter Krulevitch | Method for delivering drugs to the adventitia using device having microprojections |
| US20110046556A1 (en) * | 2009-08-22 | 2011-02-24 | Joseph Wayne Kraft | Rapid Local Anesthesia Injection Cone |
| CN102641549A (en) * | 2011-02-18 | 2012-08-22 | 帕洛阿尔托研究中心公司 | Transmucosal medicine conveying device comprising micro needles and transmucosal medicine conveying method |
| US20140276593A1 (en) * | 2013-03-15 | 2014-09-18 | Boston Scientific Scimed, Inc. | Methods and systems for treatment of a bladder |
| CN106334255A (en) * | 2016-11-14 | 2017-01-18 | 柳桂玉 | The injection administration operation device for anus and intestine surgery |
| US20180264043A1 (en) * | 2017-03-14 | 2018-09-20 | Holding Pen, Llc | Restoration of deteriorated tissue in the face or selected areas of the body with mesenchymal stem cells |
| WO2019136133A1 (en) * | 2018-01-03 | 2019-07-11 | The Trustees Of Columbia University In The City Of New York | Microneedle for local delivery of therapeutic agent |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU742061B2 (en) | Device for local administration of solid and semisolid formulations, sustained-release formulations for parenteral administration and method of preparation | |
| EP2694130B1 (en) | Variable length catheter for drug delivery | |
| JPH09507151A (en) | Prostate drug delivery catheter | |
| US20150133737A1 (en) | Apparatus and methods for accessing and sealing bodily vessels and cavities | |
| US20050021069A1 (en) | Inflatable apparatus for accessing body cavity and methods of making | |
| US6659996B1 (en) | Device for delivering biological agents | |
| EP2383009A1 (en) | Pressure/vacuum actuated catheter drug delivery probe | |
| WO2018209995A1 (en) | Stenosis dilated urinary catheter | |
| JP2010154919A (en) | Auxiliary tool for nasal cavity dilation | |
| WO2017160270A1 (en) | Modulated drug delivery | |
| CN114082085A (en) | Pre-expanding type double-layer drug perfusion balloon dilatation catheter | |
| JP2018509249A (en) | Catheter with balloon at the tip for continuous nerve block | |
| JP2014161384A (en) | Liquid sustained release means, and endoscope and endoscope surgical instrument including the same | |
| CN205903515U (en) | Balloon dilatation catheter | |
| CN110639124A (en) | Microneedle fixed-point anesthesia device | |
| US10625045B2 (en) | Expandable intra-venous catheter for a faster intra-venous fluid challenge | |
| US20240131309A1 (en) | Dilation devices and related methods | |
| CN215133645U (en) | Direction-adjustable digestive system catheter pylorus passing device | |
| CN106821765A (en) | A kind of stomach stoma and the fixed pad for stomach stoma | |
| JP3153651U (en) | Nasal tube feeding catheter with drop-off prevention cuff | |
| CN112274747A (en) | Double-layer sac tracheal catheter | |
| CN111135441A (en) | Rectum drug administration device | |
| CN219558434U (en) | Double-sac cyclic pharyngeal muscle treatment tube | |
| CN220142407U (en) | Neck bag body medicine storage type medical catheter | |
| US9370645B2 (en) | Delivery devices and related methods of use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200103 |