CN110624040A - 一种用于骨折损伤中期治疗的药物制剂及其制备方法 - Google Patents
一种用于骨折损伤中期治疗的药物制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于骨折损伤中期治疗的药物制剂及其制备方法,由赤芍、当归尾、川芎、苏木、陈皮、桃仁、续断、乳香、没药、木通、甘草、自然铜、川牛膝、骨碎补、土鳖虫、血竭、藏红花、儿茶、杜仲、白芍、肉桂、木香、刘寄奴、穿山甲、独活、羌活、防风及五加皮制成;本发明所述药物制剂具有活血止痛、接骨续筋、舒筋活络的功效,能有效治疗跌打损伤、淤血积滞经络、经脉寒湿阻滞、气血闭阻、筋肉肿痛,影响骨折生长者;本发明不仅制备方法简单,而且疗效显著,骨折损伤中期患者康复较快,达到了发明的目的。
Description
技术领域
本发明涉及一种用于骨折损伤中期治疗的药物制剂及其制备方法,属于药品技术的领域。
背景技术
骨折损伤是指由于外伤或病理原因致使骨质部分受损或完全断裂的一种疾病。其主要临床表现为:骨折部有局限性疼痛和压痛,局部肿胀和出现瘀斑,肢体功能受限或完全丧失,完全性骨质尚可出现肢体畸形及异常活动。我国在治疗骨折方面,有很丰富的经验。目前治疗这种骨折的方法有西医治疗和中医治疗。西医治疗一般采用复位、外固定或持续牵引等方法。而中医传统治疗以止痛、活血散瘀为主。在骨折治疗过程中,由于骨伤难以恢复,易遗留暗伤,并且骨伤。
所以发明一种活血止痛、去瘀生新、接骨续筋及舒筋通络效果好的用于骨折损伤中期治疗的药物制剂具有重要的意义。
发明内容
本发明的目的在于,提供一种用于骨折损伤中期治疗的药物制剂。本发明具有活血止痛、去瘀生新、接骨续筋及舒筋通络的功效,能有效治疗跌打损伤、淤血积滞经络、经脉寒湿阻滞、气血闭阻、筋肉肿痛;本发明药效显著,对骨折损伤中期患者起效较快,临床疗效好。
本发明的技术方案:一种用于骨折损伤中期治疗的药物制剂,药用有效成分照重量组份计算,由赤芍1-20份,当归尾1-20份,川芎1-15份,苏木1-15份,陈皮1-15份,桃仁1-15份,续断1-20份,乳香1-15份,没药1-15份,木通1-15份,甘草1-15份,自然铜1-30份,川牛膝1-20份,骨碎补1-30份,土鳖虫1-30份,血竭1-30份,藏红花1-20份,儿茶1-8份,杜仲1-20份,白芍1-30份,肉桂1-8份,木香1-15份,刘寄奴1-20份,穿山甲1-20份,独活1-20份,羌活1-20份,防风1-20份,五加皮1-20份制成。
前述的用于骨折损伤中期治疗的药物制剂中,所述药物制剂药用有效成分照重量组份计算,由赤芍5-15份,当归尾5-15份,川芎3-10份,苏木3-10份,陈皮3-10份,桃仁3-10份,续断5-15份,乳香3-10份,没药3-10份,木通3-10份,甘草3-10份,自然铜10-20份,川牛膝5-15份,骨碎补10-20份,土鳖虫10-20份,血竭10-20份,藏红花5-15份,儿茶1-5份,杜仲5-15份,白芍10-20份,肉桂1-3份,木香4-8份,刘寄奴5-15份,穿山甲5-15份,独活5-15份,羌活5-15份,防风5-15份,五加皮5-15份制成。
前述的用于骨折损伤中期治疗的药物制剂中,所述所述药物制剂药用有效成分按照重量组份计算,由赤芍9份,当归尾9份,川芎6份,苏木6份,陈皮6份,桃仁6份,续断12份,乳香6份,没药6份,木通6份,甘草6份,自然铜15份,川牛膝10份,骨碎补15份,土鳖虫15份,血竭15份,藏红花10份,儿茶3份,杜仲10份,白芍15份,肉桂2份,木香6份,刘寄奴9份,穿山甲10份,独活10份,羌活10份,防风10份,五加皮10份制成。
前述用于骨折损伤中期治疗的药物制剂的制备方法,取赤芍、当归尾、川芎、苏木、陈皮、桃仁、续断、乳香、没药、木通、甘草、自然铜、川牛膝、骨碎补、土鳖虫、血竭、藏红花、儿茶、杜仲、白芍、肉桂、木香、刘寄奴、穿山甲、独活、羌活、防风及五加皮,与药物中可接受的辅料进行组合,也可不加辅料,按照常规方法进行加工,制成相应的药物制剂。
前述用于骨折损伤中期治疗的药物制剂的制备方法中,所述药物制剂为口服制剂。
前述用于骨折损伤中期治疗的药物制剂的制备方法中,所述口服制剂为丸剂或散剂。
前述用于骨折损伤中期治疗的药物制剂的制备方法中,所述丸剂这样制备:取赤芍、当归尾、川芎、苏木、陈皮、桃仁、续断、木通、甘草、川牛膝、骨碎补、血竭、藏红花、儿茶、杜仲、白芍、肉桂、木香、刘寄奴、独活、羌活、防风、五加皮、自然铜、土鳖虫及穿山甲煎煮3次,第一次用12倍量的水煎煮3小时,第二次用8倍量的水煎煮2小时,第三次用6倍量的水煎煮0.5小时,过滤,合并煎液,浓缩成80℃时相对密度为 1.10-1.15的浸膏,将浸膏干燥,粉碎成细粉,备用;另取乳香和没药,粉碎成细粉,与上述药物浸膏细粉混匀,得药粉,加入药粉质量10%-30%的炼蜜和适量的水,泛丸,即得。
前述用于骨折损伤中期治疗的药物制剂的制备方法中,所述散剂这样制备:取赤芍、当归尾、川芎、苏木、陈皮、桃仁、续断、木通、甘草、川牛膝、骨碎补、血竭、藏红花、儿茶、杜仲、白芍、肉桂、木香、刘寄奴、独活、羌活、防风、五加皮、自然铜、土鳖虫及穿山甲煎煮3次,第一次用12倍量的水煎煮3小时,第二次用8倍量的水煎煮2小时,第三次用6倍量的水煎煮0.5小时,过滤,合并煎液,浓缩成80℃时相对密度为 1.10-1.15的浸膏,将浸膏干燥,粉碎成细粉,备用;另取乳香和没药,粉碎成细粉,与上述药物浸膏细粉混匀,得药粉,将药粉与药粉质量10%-30%的沉降碳酸钙混合均匀,过100目筛,分装即得。
本发明由赤芍、当归尾、川芎、苏木、陈皮、桃仁、续断、乳香、没药、木通、甘草、自然铜、川牛膝、骨碎补、土鳖虫、血竭、藏红花、儿茶、杜仲、白芍、肉桂、木香、刘寄奴、穿山甲、独活、羌活、防风及五加皮制成。其中赤芍,为毛茛科植物赤芍或川赤芍的干燥根,具有清热凉血,散瘀止痛的功效,用于热人营血,温毒发斑,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,瘾瘕腹痛,跌扑损伤,痈肿疮疡。当归尾即当归的尾部,表面黄棕色至棕褐色,具纵皱纹及横长皮孔;具有活血祛瘀的功效,用于经闭不通及瘀血积滞肿痛的病症。川芎,拉丁文名Ligusticum chuanxiong Hort.具有活血行气,祛风止痛的功效,用于活血祛瘀、瘀血阻滞、祛风止痛、风湿痹痛等症。苏木,为豆科植物苏木Caesalpinia sappan L.的干燥心材,活血祛瘀、消肿止痛的功效,用于跌打损伤,骨折筋伤,瘀滞肿痛,经闭痛经,产后瘀阻,胸腹刺痛,痈疽肿痛。陈皮,为芸香科植物橘Citrus reticulata Blanco及其栽培变种的干燥成熟果皮。桃仁,为蔷薇科植物桃Prunus persica(L.)Batsch或山桃Prunus davidiana(Carr.)Franch.的干燥成熟种子,有活血祛瘀,润肠通便,止咳平喘的功效,用于经闭痛经,瘕瘕痞块,肺痈肠痈,跌扑损伤,肠燥便秘,咳嗽气喘。续断,又名和尚头,为川续断科多年生草本植物川续断Dipsacus asper Wall.ex Henry的干燥根,有补肝肾、强筋骨、续折伤、止崩漏的功效,可用于治疗肝肾不足、腰膝酸软、风湿痹痛、筋伤骨折、崩漏、胎漏、跌扑损伤等病症。乳香,为橄榄科植物乳香树Boswellia carterii Birdw.及同属植物Boswelliabhaurdajiana Birdw.树皮渗出的树脂,有活血行气止痛,消肿生肌的功效,用于胸痹心痛,胃脘疼痛,痛经经闭,产后瘀阻,症瘕腹痛,风湿痹痛,筋脉拘挛,跌打损伤,痈肿疮疡。没药,为橄榄科植物地丁树Commiphora myrrha Engl.或哈地丁树Commiphora molmol Engl.的干燥树脂,有散瘀定痛,消肿生肌之功效,常用于胸痹心痛,胃脘疼痛,痛经经闭,产后瘀阻,癥瘕腹痛,风湿痹痛,跌打损伤,痈肿疮疡等病症的治疗。木通,为木通科植物木通Akebiaquinata(Thunb.)Decne.、三叶木通Akebia tri foliata(Thunb.)Koidz.或白木通Akebiatri oliata (Thunb.)Koidz.ar.australis(Diels)Rehd.的干燥藤茎,有利尿通淋,清心除烦,通经下乳的功效,用于淋证,水肿,心烦尿赤,口舌生疮,经闭乳少,湿热痹痛。甘草,为豆科植物甘草Glycyrrhiza uralensis Fisch.、胀果甘草Glycyrrhiza inflata Bat.或光果甘草Glycyrrhiza glabra L.的干燥根和根茎,有补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药的功效,用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。自然铜,为硫化物类矿物黄铁矿族黄铁矿,主含二硫化铁(FeS2),有散瘀止痛,续筋接骨的功效,用于跌打损伤,筋骨折伤,瘀肿疼痛。川牛膝,为苋科植物川牛膝Cyathula officinalis Kuan的干燥根,逐瘀通经,通利关节,利尿通淋的功效,用于经闭症瘕,胞衣不下,跌扑损伤,风湿痹痛,足痿筋挛,尿血血淋等证。骨碎补,真蕨目、骨碎补科蕨类植物,拉丁学名 Davallia mariesii Moore ex Bak.,具有补肾强骨,续伤止痛的功效,用于肾虚腰痛,耳鸣耳聋,牙齿松动,跌扑闪挫,筋骨折伤;外治斑秃,白癜风。土鳖虫,为鳖蠊科昆虫地鳖Eupolyph,aga sin,ensis Walker或冀地鳖Steleophaga Plancyi(Boleny)的雌虫干燥体,有破血逐瘀,续筋接骨的功效,用于跌打损伤,筋伤骨折,血瘀经闭,产后瘀阻腹痛,瘾瘕痞块。血竭,拉丁学名Daemonorops draco Bl.,为棕榈科植物麒麟竭果实渗出的树脂经加工制成,有活血定痛,化瘀止血,敛疮生肌的功效,用于跌打损伤,心腹瘀痛,外伤出血,疮疡不敛。藏红花,学名:Crocus sativus L.,又名番红花、西红花,是鸢尾科番红花属的多年生花卉,有活血化瘀,散郁开结,止痛的功效,用于治疗忧思郁结,胸膈痞闷,吐血,伤寒发狂,惊怖恍惚,妇女经闭,血滞月经不调,产后恶露不尽,瘀血作痛,麻疹,跌打损伤等。儿茶,为豆科植物儿茶Acacia catechu (L.f.)Willci.的去皮枝、干的干燥煎膏,有活血止痛,止血生肌,收湿敛疮,清肺化痰的功效,用于跌扑伤痛,外伤出血,吐血衄血,疮疡不敛,湿疹、湿疮,肺热咳嗽。杜仲,为杜仲科植物杜仲Eucommia ulmoides Oliv.的树皮,有补益肝肾、强筋壮骨、调理冲任、固经安胎的功效,可治疗肾阳虚引起的腰腿痛或酸软无力,肝气虚引起的胞胎不固,阴囊湿痒等症。白芍,为毛茛科植物芍药Paeonia tactilora Pall.的干燥根,有养血调经,敛阴止汗,柔肝止痛,平抑肝阳的功效,用于血虚萎黄,月经不调,自汗,盗汗,胁痛,腹痛,四肢挛痛,头痛眩晕。肉桂,为樟科植物肉桂Cinnamomumcassia Presl的干燥树皮,有补火助阳,引火归元,散寒止痛,温通经脉的功效,用于阳痿宫冷,腰膝冷痛,肾虚作喘,虚阳上浮,眩晕目赤,心腹冷痛,虚寒吐泻,寒疝腹痛,痛经经闭。木香,为菊科植物木香Aucklandia lappa Decne.的干燥根,有行气止痛,健脾消食的功效,用于胸胁、脘腹胀痛,泻痢后重,食积不消,不思饮食。煨木香实肠止泻。用于泄泻腹痛。刘寄奴,拉丁学名:Herba Artemisiae Anomalae,为菊科植物奇蒿的全草,有疗伤止血,破血通经,消食化积,醒脾开胃的功效,它可用于急性黄疸型肝炎,牙痛,慢性气管炎,口腔炎,咽喉炎,扁桃体炎,肾炎,疟疾;外用治眼结膜炎,中耳炎,疮疡,湿疹,外伤出血。穿山甲,拉丁名:Manis pentadactyla Linnaeus,有活血散结、通经下乳、消痈溃坚的功效,主治血瘀经闭,癥瘕,风湿痹痛,乳汁不下,痈肿,瘰疬。独活,为伞形科植物重齿毛当归Angelicapubescens Maxim.f. biserrata Shan et Yuan的干燥根,有祛风除湿,痛痹止痛的功效,用于风寒湿痹,腰膝疼痛,少阴伏风头痛,风寒挟湿头痛。羌活,拉丁名:Notopterygiumincisum Ting ex H. T. Chang,是伞形科、羌活属多年生草本植物的干燥根茎和根,有解表散寒,祛风除湿,止痛的功效,用于外感风寒、头痛无汗、寒湿痹、上肢风湿疼痛。防风,为唇形科植物广防风Epimeredi indica (L.) Rothm的地上部分,有祛风、除湿、解毒、止痛的功效,用于外感表证,风疹瘙痒,风湿痹痛,破伤风正,脾虚湿盛。五加皮,为五加科植物细柱五加Acanthopanar gracilistμlusW.W.Smith的干燥根皮,有祛风湿,补益肝肾,强筋壮骨,利水消肿的功效,用于风湿痹病,筋骨痿软,小儿行迟,体虚乏力,水肿,脚气。
方解:骨折损伤,经过早期的治疗后,血瘀气滞逐渐消退,肿胀逐渐减轻或消退,筋骨断端初步连接,疼痛明显减轻,但筋骨酸软,时有作痛,说明淤血尚未化尽,并有湿邪、寒邪侵袭、肿胀疼痛、经脉还未完全畅通,气血不畅影响骨折愈合。故治疗上当以活血止痛、去瘀生新、接骨续筋、舒筋通络之法。方中当归川芎、赤芍,桃仁、苏木、乳香、没药、穿山甲、儿茶,藏红花,活血化瘀、通经止痛;木通通脉消肿;陈皮、木香理气消滞;骨碎补土鳖虫、自然铜接骨续筋;独活、羌活、防风、五加皮祛风胜湿、通络止痛;川牛膝、杜仲、续断、舒筋活络、强壮筋骨;木香、肉桂、刘寄奴散寒行气;甘草调和主要。各药和而用之,具有活血祛瘀、接骨续筋、舒筋活络止痛的作用。
与现有技术相比,骨折损伤中期是在骨折损伤3-6周的时间内,经过早期的治疗后,血瘀气滞逐渐消退,肿胀逐渐减轻或消退,筋骨断端初步连接,疼痛明显减轻,但筋骨酸软,时有作痛,说明淤血尚未化尽,经脉还未完全畅通,气血仍欠充旺。因此,该期的治疗除继续用活血化瘀药物外,还应重视养血通络,接骨续筋,以促进筋骨愈合。本发明是在遵循骨折损伤中期病理特点的基础上,配以不同的药物组成本方剂,达到“活血止痛、接骨续筋、舒筋活络”的目的,本发明所述药物制剂具有活血止痛、接骨续筋、舒筋活络的功效,能有效治疗跌打损伤、淤血积滞经络、经脉寒湿阻滞、气血闭阻、筋肉肿痛,影响骨折生长者;本发明不仅制备方法简单,而且疗效显著,骨折损伤中期患者康复较快,达到了发明的目的。
申请人为验证本发明的效果进行了大量的实验研究,以下为本发明实验研究的结果:
一、用于跌打损伤的药效研究
本次试验选取的45例四肢骨折患者,按照随机抽样方式分为两组。研究组,男15例,女7例,年龄21岁到65岁之间,平均年龄41岁。对照组,男13例,女10例。年龄20岁到68岁之间,平均年龄41岁。其中上肢骨折患者23例,下肢骨折患者22例。两组患者一般临床资料相比,无显著差异性(P>0.05),具有可比性。
疗效判定标准:治疗痊愈表现为患者的骨折状况痊愈,关节功能恢复正常;治疗显效表现为患者的骨折状况基本痊愈,关节功能明显好转;治疗有效表现为患者的骨折状况有所好转,关节功能有所恢复;治疗无效表现为患者的骨折状况没有恢复,同时关节功能存在明显障碍。
治疗方法:骨折患者前期采用夹板固定术进行治疗,研究组患者在骨折中期服用本发明实施例1的方法制成丸剂和实施例2的方法制成的散剂,进行持续治疗,对照组患者服用常规活血汤进行持续治疗。
两组患者的临床疗效和住院时间结果对比:
研究组:痊愈15例,显效5例,有效2例,无效0例,治疗总有效率为100%,住院时间为(43.05±2.66)d;对照组:痊愈10例,显效7例,有效4例,无效2例,治疗总有效率为91.3%,住院时间为(60.32±3.58)d;两组结果对比存在显著性差异(P<0.05),具有统计学意义。
治疗结果:显效24例,有效5例,无效1例。总有效率96.7%。
结论:四肢骨折是一种常见的骨折创伤,在临床治疗过程中,经常需要花费较长的时间才能够实现治疗痊愈的效果,在患者骨折后,运动不便,而长时间的卧床会造成患者的筋肉肿痛,本发明的药物制剂具有活血止痛、接骨续筋、舒筋活络的功效,能有效治疗跌打损伤、淤血积滞经络、经脉寒湿阻滞、气血闭阻、筋肉肿痛,并有效缩短骨折恢复时间。
具体实施方式
下面结合实施例对本发明作进一步的说明,但并不作为对本发明限制的依据。
实施例1。一种用于骨折损伤中期治疗的药物制剂,所述丸剂这样制备:取赤芍9g,当归尾9g,川芎6g,苏木6g,陈皮6g,桃仁6g,续断12g,木通6g,甘草6g,川牛膝10g,骨碎补15g,血竭15g,藏红花10g,儿茶3g,杜仲10g,白芍15g,肉桂2g,木香6g,刘寄奴9g,独活10g,羌活10g,防风10g,五加皮10g,自然铜15g、土鳖虫15g及穿山甲10g,煎煮三次,第一次用12倍量的水煎煮3小时,第二次用8倍量的水煎煮2小时,第三次用6倍量的水煎煮0.5小时,过滤,合并煎液,浓缩成80℃时相对密度为的 1.13的浸膏,将浸膏干燥,粉碎成细粉,备用;另取乳香6g和没药6g,粉碎成细粉,与上述药物浸膏细粉混匀,得药粉,加入药粉质量20%的炼蜜和适量的水,泛丸,制成0.3g/丸,即得。
用法用量:每日2-3次,每次2-3丸。
实施例2:一种用于骨折损伤中期治疗的药物制剂,所述散剂这样制备:取赤芍5g,当归尾5g,川芎3g,苏木3g,陈皮3g,桃仁3g,续断5g,木通3g,甘草3g,川牛膝5g,骨碎补10g,血竭10g,藏红花5g,儿茶1g,杜仲5g,白芍10g,肉桂1g,木香4g,刘寄奴5g,独活5g,羌活5g,防风5g,五加皮5g,自然铜10g、土鳖虫10g及穿山甲5g,煎煮3 次,第一次用12倍量的水煎煮3小时,第二次用8倍量的水煎煮2小时,第三次用6倍量的水煎煮0.5小时,过滤,合并煎液,浓缩成80℃时相对密度为的 1.10的浸膏,将浸膏干燥,粉碎成细粉,备用;另取乳香3g和没药3g,粉碎成细粉,与上述药物浸膏细粉混匀,得药粉,将药粉与药粉质量10%的沉降碳酸钙混合均匀,过100目筛,分装为10g/袋即得。
用法用量:温水送服,每日2-3次,每次1-2袋。
实施例3。一种用于骨折损伤中期治疗的药物制剂,所述丸剂这样制备:取赤芍15g,当归尾15g,川芎10g,苏木10g,陈皮10g,桃仁10g,续断15g,木通10g,甘草10g,川牛膝15g,骨碎补20g,血竭20g,藏红花15g,儿茶5g,杜仲15g,白芍20g,肉桂3g,木香8g,刘寄奴15g,独活15g,羌活15g,防风15g,五加皮15g,自然铜20g、土鳖虫20g及穿山甲15g,煎煮3次,第一次用12倍量的水煎煮3小时,第二次用8倍量的水煎煮2小时,第三次用6倍量的水煎煮0.5小时,过滤,合并煎液,浓缩成80℃时相对密度为的 1.5的浸膏,将浸膏干燥,粉碎成细粉,备用;另取乳香10g和没药10g,粉碎成细粉,与上述药物浸膏细粉混匀,得药粉,将药粉与药粉质量10%的沉降碳酸钙混合均匀,过100目筛,分装为10g/袋即得。
用法用量:每日2-3次,每次1-2丸。
Claims (8)
1.一种用于骨折损伤中期治疗的药物制剂,其特征在于:药用有效成分照重量组份计算,由赤芍1-20份,当归尾1-20份,川芎1-15份,苏木1-15份,陈皮1-15份,桃仁1-15份,续断1-20份,乳香1-15份,没药1-15份,木通1-15份,甘草1-15份,自然铜1-30份,川牛膝1-20份,骨碎补1-30份,土鳖虫1-30份,血竭1-30份,藏红花1-20份,儿茶1-8份,杜仲1-20份,白芍1-30份,肉桂1-8份,木香1-15份,刘寄奴1-20份,穿山甲1-20份,独活1-20份,羌活1-20份,防风1-20份,五加皮1-20份制成。
2.根据权利要求1所述的用于骨折损伤中期治疗的药物制剂,其特征在于:所述药物制剂药用有效成分照重量组份计算,由赤芍5-15份,当归尾5-15份,川芎3-10份,苏木3-10份,陈皮3-10份,桃仁3-10份,续断5-15份,乳香3-10份,没药3-10份,木通3-10份,甘草3-10份,自然铜10-20份,川牛膝5-15份,骨碎补10-20份,土鳖虫10-20份,血竭10-20份,藏红花5-15份,儿茶1-5份,杜仲5-15份,白芍10-20份,肉桂1-3份,木香4-8份,刘寄奴5-15份,穿山甲5-15份,独活5-15份,羌活5-15份,防风5-15份,五加皮5-15份制成。
3.根据权利要求2所述的用于骨折损伤中期治疗的药物制剂,其特征在于:所述所述药物制剂药用有效成分按照重量组份计算,由赤芍9份,当归尾9份,川芎6份,苏木6份,陈皮6份,桃仁6份,续断12份,乳香6份,没药6份,木通6份,甘草6份,自然铜15份,川牛膝10份,骨碎补15份,土鳖虫15份,血竭15份,藏红花10份,儿茶3份,杜仲10份,白芍15份,肉桂2份,木香6份,刘寄奴9份,穿山甲10份,独活10份,羌活10份,防风10份,五加皮10份制成。
4.一种如权利要求1-3任一项所述用于骨折损伤中期治疗的药物制剂的制备方法,其特征在于:取赤芍、当归尾、川芎、苏木、陈皮、桃仁、续断、乳香、没药、木通、甘草、自然铜、川牛膝、骨碎补、土鳖虫、血竭、藏红花、儿茶、杜仲、白芍、肉桂、木香、刘寄奴、穿山甲、独活、羌活、防风及五加皮,与药物中可接受的辅料进行组合,也可不加辅料,按照常规方法进行加工,制成相应的药物制剂。
5.根据权利要求4所述用于骨折损伤中期治疗的药物制剂的制备方法,其特征在于:所述药物制剂为口服制剂。
6.根据权利要求5所述用于骨折损伤中期治疗的药物制剂的制备方法,其特征在于:所述口服制剂为丸剂或散剂。
7.根据权利要求6所述用于骨折损伤中期治疗的药物制剂的制备方法,其特征在于:所述丸剂这样制备:取赤芍、当归尾、川芎、苏木、陈皮、桃仁、续断、木通、甘草、川牛膝、骨碎补、血竭、藏红花、儿茶、杜仲、白芍、肉桂、木香、刘寄奴、独活、羌活、防风、五加皮、自然铜、土鳖虫及穿山甲煎煮3 次,第一次用12倍量的水煎煮3小时,第二次用8倍量的水煎煮2小时,第三次用6倍量的水煎煮0.5小时,过滤,合并煎液,浓缩成80℃时相对密度为 1.10-1.15的浸膏,将浸膏干燥,粉碎成细粉,备用;另取乳香和没药,粉碎成细粉,与上述药物浸膏细粉混匀,得药粉,加入药粉质量10%-30%的炼蜜和适量的水,泛丸,即得。
8.根据权利要求6所述用于骨折损伤中期治疗的药物制剂的制备方法,其特征在于:所述散剂这样制备:取赤芍、当归尾、川芎、苏木、陈皮、桃仁、续断、木通、甘草、川牛膝、骨碎补、血竭、藏红花、儿茶、杜仲、白芍、肉桂、木香、刘寄奴、独活、羌活、防风、五加皮、自然铜、土鳖虫及穿山甲煎煮3 次,第一次用12倍量的水煎煮3小时,第二次用8倍量的水煎煮2小时,第三次用6倍量的水煎煮0.5小时,过滤,合并煎液,浓缩成80℃时相对密度为 1.10-1.15的浸膏,将浸膏干燥,粉碎成细粉,备用;另取乳香和没药,粉碎成细粉,与上述药物浸膏细粉混匀,得药粉,将药粉与药粉质量10%-30%的沉降碳酸钙混合均匀,过100目筛,分装即得。
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