CN110585269A - Preparation method of compound radix bupleuri and scutellaria baicalensis suppository - Google Patents

Preparation method of compound radix bupleuri and scutellaria baicalensis suppository Download PDF

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CN110585269A
CN110585269A CN201910965243.1A CN201910965243A CN110585269A CN 110585269 A CN110585269 A CN 110585269A CN 201910965243 A CN201910965243 A CN 201910965243A CN 110585269 A CN110585269 A CN 110585269A
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suppository
radix bupleuri
extract
compound
mixing
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刘俊霞
窦凤鸣
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Jilin Agricultural Science and Technology College
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Jilin Agricultural Science and Technology College
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a preparation method of a compound radix bupleuri and scutellaria baicalensis suppository, which comprises the following steps: s1, mixing and decocting the radix bupleuri and the radix scutellariae according to the mass ratio of 1:2 to prepare an extract; s2, weighing the following components in percentage by mass: 43.7% of extract, 43.7% of 36# -38# (1: 1) mixed fatty glyceride, 1.7% of liquid paraffin, 802.2% of tween-and 8.7% of lanolin; s3, mixing the weighed mixed fatty glyceride No. 36-38 (1: 1), liquid paraffin, tween-80 and lanolin, heating in a water bath at 50 deg.C to melt, adding the weighed extract, stirring, molding, cooling for 20 min, and demolding. The preparation process disclosed by the invention is good in stability and simple to operate, the prepared suppository is smooth in appearance, the medicines are uniformly mixed, and the hardness is appropriate, so that a foundation is provided for researching the compound radix bupleuri and radix scutellariae suppository.

Description

Preparation method of compound radix bupleuri and scutellaria baicalensis suppository
Technical Field
The invention relates to the field of preparation of traditional Chinese medicine preparations, in particular to a preparation method of a compound radix bupleuri and radix scutellariae suppository.
Background
The prescription of the compound bupleurum root and scutellaria root suppository is derived from the bupleurum root and scutellaria root tablets recorded in the Chinese patent medicine finished prescription preparation. Bupleuri radix is a common wind-heat-dispersing medicine, and is whole herb or root of Bupleurum scorzonerifolium and Bupleurum scorzonerifolium of Umbelliferae. Scutellaria baicalensis is a commonly used heat-clearing and dampness-drying drug and is the dried root of Scutellaria baicalensis Georgi of Labiatae. The radix bupleuri has the functions of soothing liver, invigorating yang, harmonizing exterior and interior, and the radix scutellariae has the functions of dispelling wind, clearing lung, freeing lung and relieving cough, has the functions of clearing heat, soothing liver, harmonizing shaoyang and has a wide clinical application basis. The bupleurum and the scutellaria are combined, are firstly seen in a small bupleurum decoction formula in Shanghai treatise on typhoid fever, are the most significant compatibility in Shaoyang prescriptions, are matched with chai Huang to play the effects of penetrating and dispersing half exterior pathogens and inclining half interior heat, clear heat and release exterior, have obvious curative effects on symptoms such as fever, malaise, dizziness, sore throat and the like caused by wind-heat cold, are inspired by the compatibility of chai Huang, and are prepared into chai Huang granules, chai Huang soft capsules, chai Huang freeze-dried powder injection and other products according to different proportions, and are composed of the bupleurum and the scutellaria.
The route of administration of suppositories is distinguished from other dosage forms. The suppository can have local effect in cavity, such as antibacterial effect in matrine suppository for treating bacterial vaginosis, analgesic effect in anti-inflammatory analgesic suppository and compound four-yellow suppository for relieving pain after anorectal operation, antiinflammatory effect in astragalus yellow suppository for treating chronic ulcerative colitis or lubricating, insecticidal, astringent, and antipruritic effects of other suppositories. The suppository has other advantages, such as reducing or avoiding gastrointestinal pH value or enzyme damage to medicine; the irritation of the gastric mucosa to the medicine is reduced; the drug in the suppository is absorbed through the rectal veins to avoid the first-pass effect of the liver; provides convenience for patients who cannot or do not want to take the medicine orally; for the medicines which are not suitable for oral administration, the preparation of suppository is also a better choice.
Common suppository of bupleurum root and scutellaria root is not available in the market.
Disclosure of Invention
The invention aims to provide a preparation method of a compound radix bupleuri and radix scutellariae suppository, which has the advantages of good preparation process stability, simple operation, smooth appearance of the prepared suppository, uniform medicine mixing and proper hardness.
In order to achieve the purpose, the invention adopts the technical scheme that:
the preparation method of the compound bupleurum root and scutellaria root suppository comprises the following steps:
s1, mixing the radix bupleuri and the radix scutellariae in a boiling pot according to the mass ratio of 1:2, adding 8 times of water, soaking for 0.5 h, heating to boil, continuing to heat for 1 h under the slightly boiling state, separating and filtering medicine dregs by gauze, and collecting filtrate; adding 5 times of water into the residue, heating for 0.5 hr under slightly boiling state, separating and filtering the residue, mixing the filtrates, and concentrating under heating to obtain extract with concentration of 5 g/mL;
s2, weighing the following components in percentage by mass:
43.7% of extract, 43.7% of 36# -38# (1: 1) mixed fatty glyceride, 1.7% of liquid paraffin, 802.2% of tween-and 8.7% of lanolin;
s3, mixing the weighed mixed fatty glyceride No. 36-38 (1: 1), liquid paraffin, tween-80 and lanolin, heating in a water bath at 50 deg.C to melt, adding the weighed extract, stirring, molding, cooling for 20 min, and demolding.
The preparation process disclosed by the invention is good in stability and simple to operate, the prepared suppository is smooth in appearance, the medicines are uniformly mixed, and the hardness is appropriate, so that a foundation is provided for researching the compound radix bupleuri and radix scutellariae suppository.
Drawings
FIG. 1 is a process flow diagram of an embodiment of the present invention.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.
Examples
Extraction of Bupleurum root and Baikal skullcap root
Weighing 50 g of radix bupleuri and 100 g of radix scutellariae by using an electronic balance, putting into a boiling pot, mixing, adding 8 times of water, soaking for 0.5 h, heating to boil, continuously heating for 1 h under the condition of keeping a slightly boiling state, separating and filtering medicine residues by using gauze, and collecting filtrate; adding 5 times of water into the residue, heating under slightly boiling state for 0.5 hr, separating and filtering the residue, and mixing the two filtrates. And heating and concentrating the filtrate to obtain an extract with the concentration of about 5 g/mL of the original medicinal material for later use.
Single factor investigation
Screening of mixed fatty glyceride of different types
In the test, mixed fatty glyceride is selected as a suppository matrix, and because the properties of different types of mixed fatty glycerides are different, the mixed fatty glycerides of No. 36, No. 38 and No. 36-38 (1: 1) are selected to be tested, the mixed fatty glycerides are heated to be molten in a water bath at 50 ℃, 10 mL of liquid medicine (namely 5 g/mL of extract) is respectively added, the mixture is uniformly stirred, the mixture is filled into a mold, the mixture is cooled for 20 min, and the mold is removed. Screening different types of mixed fatty glyceride by using the hardness of the suppository mixed with the matrix and the medicine mixing uniformity as detection indexes[16]。
Screening of matrix formulations
Weighing three different matrix formulations shown in Table 1, heating in water bath at 50 deg.C to melt, respectively adding 10 mL medicinal liquid (5 g/mL extract), stirring, molding, cooling for 20 min, and demolding. The proper matrix formula is preferably selected by taking the hardness and the medicine mixing uniformity of the suppository as detection indexes.
TABLE 1 matrix formulation
Screening the dosage ratio of the matrix and the medicament, weighing 3 parts of matrix formula in proportion, placing the matrix formula in a beaker, melting in a water bath at 50 ℃, weighing 0.75 time, 1 time and 1.5 times of the medicament respectively, stirring uniformly, filling a mold, cooling for 20 min, and demolding to obtain the medicament. The proper dosage ratio of the matrix to the medicine is preferably selected by taking the appearance of the suppository and the medicine mixing uniformity as detection indexes.
Screening of Water bath temperature
Weighing 3 parts of matrix formula according to a proportion, placing in a beaker, heating in water bath at 45 ℃, 50 ℃ and 55 ℃ respectively until the matrix formula is melted, adding the preferred drug dosage according to the above steps respectively, stirring uniformly, filling into a mold, cooling for 20 min, and demolding to obtain the product. The suppository is screened by taking the appearance and the medicine mixing uniformity of the suppository as detection indexes.
Screening of Cooling time
Weighing three parts of matrix formula according to a certain proportion, placing in a beaker, heating in water bath at a preferred proper temperature until the matrix is melted, respectively adding a proper amount of medicine, stirring uniformly, filling into a mold, respectively cooling for 15 min, 20 min and 25 min, and demolding to obtain the product. The obtained suppository is screened by using appearance and hardness as detection indexes.
Preparation process for optimizing compound radix bupleuri and radix scutellariae suppository by orthogonal test method
With reference to the preliminary experimental investigation results, use L9(34) Orthogonal experiment, using fusion time limit as evaluation index, optimizing preparation process of the compound radix bupleuri and radix Scutellariae suppository, wherein the factor level table is shown in Table 2.
TABLE 2 factors and levels
Confirmatory experiment
3 batches of 10 samples were prepared according to the preferred optimal recipe process. The suppository was evaluated for appearance, hardness, and uniformity of drug mixing. Experiments prove that the compound radix bupleuri and radix scutellariae suppository has stable process and feasibility.
Calculation of permutation price
The replacement value was calculated from 10 pure matrix suppositories without drug and 10 compound suppositories of Bupleurum and Scutellaria baicalensis according to the following formula.
W: average drug content of suppository
Y: weight of drug
J: weight of substrate
G: average weight of pure matrix plug
M: mean suppository weight of the suppository
Quality inspection of compound radix bupleuri and radix scutellariae suppository
Character inspection of compound radix bupleuri and radix scutellariae suppository
The suppository should have the drug and matrix mixed uniformly and the shape should be complete and smooth.
Weight difference examination of compound radix bupleuri and radix Scutellariae suppository
The examination of the weight difference refers to the method of pharmacopoeia of the people's republic of China (2015 edition), 10 compound Bupleurum baicalensis suppository samples are taken, the total mass of 10 suppositories is precisely weighed, the average mass of 10 suppositories is calculated, and then the mass of each suppository is precisely weighed. Calculating the weight difference of the compound radix bupleuri and radix scutellariae suppository to meet the requirement.
TABLE 3 suppository weight variation limits
Melting time limit inspection of compound radix bupleuri and radix scutellariae suppository
The melting time limit inspection method is characterized in that inspection is carried out according to pharmacopoeia of the people's republic of China (2015 edition), 3 compound bupleurum baical skullcap root suppository samples are taken and placed for one hour at room temperature, and then melting time limit is measured, wherein the melting time limit is required to be in accordance with the specification.
Test results and analysis
Extraction result of bupleuri radix and Scutellariae radix
TABLE 4 extraction results
The extraction results in Table 4 show that the average yield of bupleuri radix and Scutellariae radix is 23.92%.
Single factor investigation results and analysis
Screening results of different types of mixed fatty glyceride
TABLE 5 matrix screening
The test results in Table 5 show that 36# or 38# mixed fatty glyceride can be uniformly mixed with the medicine when being used as the matrix alone, but the prepared suppository has poor hardness quality effect, and when 36# and 38# mixed fatty glyceride is mixed in a ratio of 1:1, the matrix and the medicine are uniformly mixed and have moderate hardness, so the 36# -38# (1: 1) mixed fatty glyceride is more suitable for being used as the matrix of the compound radix bupleuri and radix scutellariae suppository.
Screening results of matrix formulations
Table 6 matrix formulation screening
The test results are shown in Table 6, and the suppository prepared according to the base formula 1 has smooth shape, moderate hardness, but non-uniform color and drug aggregation. The suppository prepared according to the base formula 3 has uniform color, is uniformly mixed with the medicine, has sticky feeling and is softer when in contact. The suppository prepared according to the matrix formula 2 has moderate hardness, and the medicines are uniformly mixed, namely the mixed fatty glyceride, the liquid paraffin, the Tween-80 and the lanolin have better effect when the ratio of the mixed fatty glyceride to the liquid paraffin to the lanolin is 10:0.1:1.2: 0.
Screening results of matrix to drug dose ratio
TABLE 7 screening of matrix to drug dose ratios
As shown in Table 7, when 0.75 time and 1 time of the drug as the matrix are added, the suppository matrix and the drug are uniformly mixed, the appearance is complete and smooth, the color is uniform, and the requirements are met, so that the drug loading capacity is increased as much as possible under the condition of ensuring the quality of the suppository, and the ratio of the matrix to the drug dosage is finally determined to be 1:1.
Screening results of Water bath temperature
TABLE 8 screening of Water bath temperatures
The test results are shown in table 8, when the temperature of the water bath is too high, the liquid medicine sinks, so that the suppository medicine is not uniformly mixed, and even the suppository is partially incomplete; when the temperature of the water bath is too low, the suppository turns into flower, the medicine is not uniformly mixed, and the appearance of the suppository is affected. The bath temperature is preferably 50 ℃.
Screening results of Cooling time
TABLE 9 screening of Cooling times
As shown in Table 9, the cooling for too long a period of time makes it difficult to scrape the overflowing part and makes it easy for the suppository to crack or even break, and if the cooling for too short a period of time makes the bottom cut of the suppository not smooth when the suppository scrapes the overflowing part, which not only disturbs the appearance of the suppository but also affects the quality. According to the experimental result, the optimal cooling time for preparing the compound radix bupleuri and radix scutellariae suppository is 20 min.
Preparation process result and analysis of compound radix bupleuri and radix Scutellariae suppository optimized by orthogonal test
TABLE 10 orthogonal test results of preparation process of FUFANGCHAIHUHUANGQIN suppository
As shown in the results of the orthogonal experiments in Table 10, A, B, C, D factors have influence on the preparation of the suppository containing bupleuri radix and Scutellariae radix in the order of B>D>C>A. Factor AIn A3>A1>A2In the B factor B2>B3>B1In the C factor C2>C3>C1In D factor D2>D1>D3. The best process is A3B2C2D2。
Results of confirmatory experiments
TABLE 11 results of confirmatory experiments
As can be seen from the results of the confirmatory experiments in Table 11, the compound suppository prepared by the orthogonal experiment optimization has the advantages of complete and smooth appearance, moderate hardness, uniform medicine mixing and stable and feasible preparation process.
Calculation result of permutation price
TABLE 12 amount of suppository-containing material
TABLE 13 suppository weights
Substituting the data in tables 12 and 13 into the substitution value calculation formula to obtain the substitution value of the compound radix bupleuri and radix Scutellariae suppository of 1.19.
Quality inspection result of compound radix bupleuri and radix scutellariae suppository
Traits
The compound suppository is brown bullet suppository with complete appearance, smooth and uniform color.
Difference in weight
Weight difference of compound radix bupleuri and radix Scutellariae suppository in Table 14
As can be seen from Table 14, the weight difference of the FUFANGCHAIHUQINGHUANGQIN suppository is calculated to be within-0.94% ~ 1.23.23%, and all of them meet the weight difference limit of + -7.5%.
Time limit of fusion
TABLE 15 melting time of FUFANGCHAIHUQINGHUANGSHUAN
As can be seen from Table 15, the melting time of the samples was less than 30 min, and the samples were in accordance with the specification.
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention. The embodiments and features of the embodiments of the present application may be combined with each other arbitrarily without conflict.

Claims (1)

1. The preparation method of the compound radix bupleuri and radix scutellariae suppository is characterized in that: the method comprises the following steps:
s1, mixing the radix bupleuri and the radix scutellariae in a boiling pot according to the mass ratio of 1:2, adding 8 times of water, soaking for 0.5 h, heating to boil, continuing to heat for 1 h under the slightly boiling state, separating and filtering medicine dregs by gauze, and collecting filtrate; adding 5 times of water into the residue, heating for 0.5 hr under slightly boiling state, separating and filtering the residue, mixing the filtrates, and concentrating under heating to obtain extract with concentration of 5 g/mL;
s2, weighing the following components in percentage by mass:
43.7% of extract, 43.7% of 36# -38# (1: 1) mixed fatty glyceride, 1.7% of liquid paraffin, 802.2% of tween-and 8.7% of lanolin;
s3, mixing the weighed mixed fatty glyceride No. 36-38 (1: 1), liquid paraffin, tween-80 and lanolin, heating in a water bath at 50 deg.C to melt, adding the weighed extract, stirring, molding, cooling for 20 min, and demolding.
CN201910965243.1A 2019-10-11 2019-10-11 Preparation method of compound radix bupleuri and scutellaria baicalensis suppository Pending CN110585269A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112168928A (en) * 2020-08-23 2021-01-05 莫兆钦 Application and preparation of Chinese herbal medicine cold fever reducing gel paste
CN113304193A (en) * 2021-05-28 2021-08-27 肖萍 Corydalis saxicola bunting for treating and/or preventing pelvic inflammation and preparation method thereof

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CN1686424A (en) * 2005-04-28 2005-10-26 邝继鲜 Medicinal composition containing scutellaria and bupleurum and its preparation method

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112168928A (en) * 2020-08-23 2021-01-05 莫兆钦 Application and preparation of Chinese herbal medicine cold fever reducing gel paste
CN113304193A (en) * 2021-05-28 2021-08-27 肖萍 Corydalis saxicola bunting for treating and/or preventing pelvic inflammation and preparation method thereof
CN113304193B (en) * 2021-05-28 2022-07-15 肖萍 Corydalis saxicola bunting for treating and/or preventing pelvic inflammation and preparation method thereof

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Application publication date: 20191220

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