CN110575403A - preparation method capable of reducing addition amount of chemical sunscreen agent in sunscreen milk - Google Patents
preparation method capable of reducing addition amount of chemical sunscreen agent in sunscreen milk Download PDFInfo
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- CN110575403A CN110575403A CN201911024171.7A CN201911024171A CN110575403A CN 110575403 A CN110575403 A CN 110575403A CN 201911024171 A CN201911024171 A CN 201911024171A CN 110575403 A CN110575403 A CN 110575403A
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- sunscreen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a preparation method capable of reducing the addition of a chemical sunscreen agent in sunscreen milk, which belongs to the technical field of preparation of skin care product compositions, and the composition capable of reducing the addition of the chemical sunscreen agent in sunscreen milk comprises the following components in parts by weight: tetrahydro-methyl-pyrimidine-carboxylic acid: 0.5-1 part; glycerol glucoside: 1-3 parts; 1,2 hexanediol: 0.5-1 part; fullerene: 1 part; water: 5 parts, the tetrahydro-methyl pyrimidine carboxylic acid (Ectoin) of the invention inhibits the expression of inflammatory gene ICAM-1, can effectively resist the damage caused by ultraviolet light to epidermal cells, and the glycerol glucoside resists the oxidation pressure caused by ultraviolet light by increasing the content of SOD1 in the cells, delays the time of skin generating erythema, relatively increases the SPF value, and reduces the addition amount of chemical sun-screening agents.
Description
Technical Field
the invention relates to the field of skin care products, in particular to a preparation method capable of reducing the addition of a chemical sun-screening agent in sun-screening milk.
Background
At present, the skin care products on the market have various types and different efficacies, including whitening, moisturizing, freckle removing, aging resisting and the like. However, many products are added with a few chemical substances which are harmful to human bodies, and although the substances have skin care effects of short-term whitening, anti-aging and the like on human skin, if the substances are used for a long time, the skin is seriously damaged, and acne, color spots, lipid secretion disorder and the like appear; sunscreen products play an important role in personal care products for combating skin aging, since ultraviolet rays from the sun carry different energy bands, UVA & UVB cause uneven skin color, collagen decomposition leads to wrinkle generation, and even more extension sunburn skin, the main function of the imitation sun-proof product is to use physical and chemical sun-proof as the substrate to block UVA and UVB, however, SPF is defined as the multiple of the red inflammation time generated after the skin of each person absorbs the energy of ultraviolet light, it is also contemplated that if the time for skin redness is delayed or the expression of the inflammation gene ICAM-1 is suppressed according to the basic definition of SPF, can effectively resist the damage caused by ultraviolet light to epidermal cells and resist the oxidation pressure caused by ultraviolet light by increasing the content of SOD1 in the cells, therefore, we propose a preparation method which can reduce the addition amount of the chemical sunscreen agent in the sunscreen milk.
disclosure of Invention
The invention aims to solve the defects in the prior art and provides a preparation method capable of reducing the addition amount of a chemical sunscreen agent in sunscreen milk.
In order to achieve the purpose, the invention adopts the following technical scheme: a preparation method for reducing the addition amount of a chemical sunscreen agent in sunscreen milk comprises the following steps:
Preferably, the preparation method for reducing the addition amount of the chemical sunscreen agent in the sunscreen milk comprises the following steps:
S1: screening raw materials: preparing the base ingredients in parts by weight of the composition of claim 1: tetrahydro-methyl-pyrimidine-carboxylic acid: 0.5-1 part; glycerol glucoside: 1-3 parts; 1,2 hexanediol: 0.5-1 part; fullerene: 1 part; water: 5 parts of a mixture;
s2: stirring for the first time: reacting the tetrahydro-methyl-pyrimidine-carboxylic acid selected in step S1: 0.5-1 part; glycerol glucoside: 1-3 parts; 1,2 hexanediol: 0.5-1 part; fullerene: 1 part; water: 5 parts of the mixture is fully and uniformly stirred in an ultrasonic oscillator, heated to 40 ℃, and then kept stand for 15 minutes to obtain a mixture for later use;
s3: stirring for the second time: the mixture obtained in step S1 was stirred again in an ultrasonic oscillator for 30 minutes to confirm complete dispersion, and a finished composition was obtained.
preferably, the ultrasonic oscillator model in the steps S2 and S3 is DL-480E.
preferably, the composition finished product obtained in the step S3 can replace the water content in the sunscreen lotion.
The preparation method for reducing the addition of the chemical sunscreen agent in the sunscreen milk provided by the invention can effectively resist the damage caused by ultraviolet light by inhibiting the expression of the inflammatory gene ICAM-1 and resist the oxidation pressure caused by ultraviolet light by increasing the content of SOD1 in cells so as to reduce the addition of the chemical sunscreen agent.
Drawings
FIG. 1 is a flow chart of the preparation of the present invention;
FIG. 2 shows that the present invention utilizes glycerol glucoside to increase the content of SOD1 in cells to achieve the effect of anti-oxidation;
FIG. 3 is a graph showing that the resistance of the cells to UVA and visible light is increased by the tetrahydromethylpyrimidine carboxylic acid (Ectoin) according to the present invention;
FIG. 4 is a graph showing that Ectoin prevents UVB-induced cell damage in 89% compared to placebo, resulting in UVB protection;
FIG. 5 shows that the cells treated with Ectoin according to the present invention can efficiently organize the UVA radiation-induced inflammatory response by measuring the gene expression level of ICAM-1.
Detailed Description
in order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
A preparation method for reducing the addition amount of a chemical sunscreen agent in sunscreen milk comprises the following steps:
The preparation method capable of reducing the addition amount of the chemical sunscreen agent in the sunscreen milk comprises the following steps:
s1: screening raw materials: preparing the base ingredients in parts by weight of the composition of claim 1: tetrahydro-methyl-pyrimidine-carboxylic acid: 0.5-1 part; glycerol glucoside: 1-3 parts; 1,2 hexanediol: 0.5-1 part; fullerene: 1 part; water: 5 parts of a mixture;
s2: stirring for the first time: reacting the tetrahydro-methyl-pyrimidine-carboxylic acid selected in step S1: 0.5-1 part; glycerol glucoside: 1-3 parts; 1,2 hexanediol: 0.5-1 part; fullerene: 1 part; water: 5 parts of the mixture is fully and uniformly stirred in an ultrasonic oscillator, heated to 40 ℃, and then kept stand for 15 minutes to obtain a mixture for later use;
S3: stirring for the second time: the mixture obtained in step S1 was stirred again in an ultrasonic oscillator for 30 minutes to confirm complete dispersion, and a finished composition was obtained.
Wherein the ultrasonic oscillator model number in the steps S2 and S3 is DL-480E; the composition finished product prepared in the step S3 can replace the content of water in the sunscreen milk.
According to FIG. 3, comet electrophoresis measures the photoprotective ability of Ectoin against UVA/visible and visible radiation, pretreated with 0.025, 0.05 and 0.1mM Ectoin, respectively, and irradiated the keratinocytes with 15J/cm2 of composite light (UVA/visible) and visible light, respectively.
Referring to fig. 1-4, the expression of the inflammatory gene ICAM-1, which is inhibited by Ectoin (Ectoin), is effective in protecting epidermal cells from damage caused by ultraviolet light, and the oxidation pressure caused by ultraviolet light is resisted by the glycerol glucoside through increasing the content of SOD1 in the cells, so that the generation time of erythema on the skin is prolonged, and the addition amount of the chemical sunscreen agent is relatively increased by increasing the SPF value.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. A preparation method capable of reducing the addition amount of a chemical sunscreen agent in sunscreen milk is characterized in that: the composition capable of reducing the addition amount of the chemical sunscreen agent in the sunscreen milk comprises the following components in parts by weight:
2. a method for preparing a sunscreen lotion according to claim 1, wherein the amount of the chemical sunscreen added to the sunscreen lotion is reduced by: the preparation method capable of reducing the addition amount of the chemical sunscreen agent in the sunscreen milk comprises the following steps:
S1: screening raw materials: preparing the base ingredients in parts by weight of the composition of claim 1: tetrahydro-methyl-pyrimidine-carboxylic acid: 0.5-1 part; glycerol glucoside: 1-3 parts; 1,2 hexanediol: 0.5-1 part; fullerene: 1 part; water: 5 parts of a mixture;
S2: stirring for the first time: reacting the tetrahydro-methyl-pyrimidine-carboxylic acid selected in step S1: 0.5-1 part; glycerol glucoside: 1-3 parts; 1,2 hexanediol: 0.5-1 part; fullerene: 1 part; water: 5 parts of the mixture is fully and uniformly stirred in an ultrasonic oscillator, heated to 40 ℃, and then kept stand for 15 minutes to obtain a mixture for later use;
S3: stirring for the second time: the mixture obtained in step S1 was stirred again in an ultrasonic oscillator for 30 minutes to confirm complete dispersion, and a finished composition was obtained.
3. the method for preparing a sunscreen lotion capable of reducing the addition of chemical sunscreen agents as claimed in claim 2, wherein: the ultrasonic oscillator model in the steps S2 and S3 is DL-480E.
4. The method for preparing a sunscreen lotion capable of reducing the addition of chemical sunscreen agents as claimed in claim 2, wherein: the composition finished product prepared in the step S3 can replace the content of water in the sunscreen milk.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911024171.7A CN110575403A (en) | 2019-10-25 | 2019-10-25 | preparation method capable of reducing addition amount of chemical sunscreen agent in sunscreen milk |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911024171.7A CN110575403A (en) | 2019-10-25 | 2019-10-25 | preparation method capable of reducing addition amount of chemical sunscreen agent in sunscreen milk |
Publications (1)
| Publication Number | Publication Date |
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| CN110575403A true CN110575403A (en) | 2019-12-17 |
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| CN201911024171.7A Pending CN110575403A (en) | 2019-10-25 | 2019-10-25 | preparation method capable of reducing addition amount of chemical sunscreen agent in sunscreen milk |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511255A (en) * | 2016-11-14 | 2017-03-22 | 广州蜜妆生物科技有限公司 | Multi-azimuth skin protecting cream |
| CN107252427A (en) * | 2012-07-09 | 2017-10-17 | 比托普股份公司 | For the composition for including active material for the bodily tissue regeneration for promoting damage |
| CN110141537A (en) * | 2019-03-05 | 2019-08-20 | 德亚生物科技有限公司 | A kind of nursing lotion and preparation method thereof with reparation skin barrier |
-
2019
- 2019-10-25 CN CN201911024171.7A patent/CN110575403A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107252427A (en) * | 2012-07-09 | 2017-10-17 | 比托普股份公司 | For the composition for including active material for the bodily tissue regeneration for promoting damage |
| CN106511255A (en) * | 2016-11-14 | 2017-03-22 | 广州蜜妆生物科技有限公司 | Multi-azimuth skin protecting cream |
| CN110141537A (en) * | 2019-03-05 | 2019-08-20 | 德亚生物科技有限公司 | A kind of nursing lotion and preparation method thereof with reparation skin barrier |
Non-Patent Citations (2)
| Title |
|---|
| 刘宝琴: "《百姓健康专家谈（四）》", 31 July 2019, 陕西科学技术出版社 * |
| 深圳市阳光优品科技有限公司: "婷娟壹生防护隔离乳", 《电子凭证-国产非特殊用途化妆品备案信息服务平台》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191217 |
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| RJ01 | Rejection of invention patent application after publication |