CN110564888A - 一个影响玉米南方锈病抗性的主效qtl及其应用 - Google Patents
一个影响玉米南方锈病抗性的主效qtl及其应用 Download PDFInfo
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- CN110564888A CN110564888A CN201910955604.4A CN201910955604A CN110564888A CN 110564888 A CN110564888 A CN 110564888A CN 201910955604 A CN201910955604 A CN 201910955604A CN 110564888 A CN110564888 A CN 110564888A
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Abstract
本发明公开了一个影响玉米南方锈病抗性的主效QTL，位于第10号染色体的短臂上，在标记10‑1523544与标记10‑1712625之间，存在一个主效候选基因LOC103640673，所述主效QTL位点对南方锈病抗性的表型变异解释率为49.6％，可应用于玉米育种。本发明提供的影响玉米南方锈病抗性的主效QTL可在玉米育种中应用，能够解决传统选育的效率低和周期长的难题。
Description
技术领域
本发明属于分子生物学技术领域，涉及一个影响玉米南方锈病抗性的主效QTL及其应用。
背景技术
玉米(Zea mays L.)是重要的粮食作物。玉米南方锈病(Southern Corn Rust)是一种全球出没的气传病害，在热带、亚热带、温带包括非洲、东南亚、澳洲、南美洲、美国南部、环南印度洋国家等地区均有发生的踪迹。在中国，由南向北多个玉米产区病情均有过报道。南方锈病病原为多堆柄锈菌Puccinia polysora Underw。与普通锈病不同，南方锈病一旦大流行，严重时会造成40-80％的产量损失，甚至颗粒无收。由于目前对玉米南方锈病的发生规律尚未明了，难于预防，加之病害主要在玉米生长后期发生，此时植株高大，杀菌剂增加种植成本的同时也难于被喷洒入植株冠层内部，使防治效果大打折扣。几十年的生产实践经验表明，防治南方锈病最有效的措施还是主栽抗性品种。
玉米南方锈病抗性是数量性状，受主效单基因+微效多基因控制。研究表明玉米南方锈病抗性遗传力高，非常适用于分子标记辅助育种。
许多学者对玉米南方锈病抗性基因进行了QTL定位，到2019年为止，在玉米中已报道了7个南方锈病抗性主效QTL位点，发现玉米南方锈病抗性基因定位在玉米第10染色体短臂上。目前分子标记辅助选择(Molecular Marker－assisted Selection，MAS)已经与传统杂交方法结合应用于抗南方锈病玉米品种的培育，通过分子标记辅助选择对这些品种聚合抗病基因的最适基因型组合，增加其抗性，这种提高南宁玉米锈病抗性的改良将大大提高育种效率，带来巨大的社会经济效益。进一步充分利用品种资源，继续充分挖掘资源中的玉米南方锈病抗性有利基因是具有潜力的研发方向。
发明内容
本发明的目的是提供一个影响玉米南方锈病抗性的主效QTL，主效QTL位于第10号染色体的短臂上，在标记10-1523544与标记10-1712625之间。
所述主效QTL位点存在一个主效候选基因LOC103640673，所述主效候选基因LOC103640673的碱基序列如SEQ ID NO.1所示，其编码1个与抗病基因RPP13类似的蛋白，所述蛋白的氨基酸序列如SEQ ID NO.2所示，而RPP13是拟南芥中发现的1个霜霉病抗性基因。所述的主效QTL位点对南方锈病抗性的表型变异解释率为49.6％。
作图群体是由182株T2代组成的群体，其亲本的母本为PHW52，父本为抗玉米南方锈病S313；所述的主效QTL位点正向等位变异来自于S313。
所述的主效QTL位点可在玉米育种中应用，具体地，可在培育具有抗玉米南方锈病能力玉米中应用。
本发明的有益效果
本发明在本专利在玉米第10号染色体短臂上定位了1个新的主效QTL，显著影响玉米对南方锈病的抗性，该位点正向等位变异来自于玉米品种S313，为玉米抗性育种提供了新的等位基因。与该QTL紧密连锁的标记10-1523544与标记10-1712625均可以转换为KASP标记，用于分子标记辅助育种。该主效QTL位点上存在一个主效候选基因LOC103640673，为玉米育种提供了可用基因。本发明提供的影响玉米南方锈病抗性的主效QTL可在玉米育种中应用，能够解决传统选育的效率低和周期长的难题。
附图说明
图1为182个单株F2群体局部遗传图谱
图2为玉米南方锈病主效QTL定位图
具体实施方式
以下实施例进一步说明本发明的内容，但不应理解为对本发明的限制。在不背离本发明精神和实质的情况下，对本发明方法、步骤或条件所作的修改或替换，均属于本发明的范围。
下述实施例中所使用的实验方法如无特殊说明，均为常规方法。下述实施例中所使用的材料、试剂等，如无特殊说明，均可从商业途径得到。
实施例1
1、实验材料和田间管理
2016年秋季，以感玉米南方锈病自交系PHW52为母本，抗玉米南方锈病S313为父本，配制F1代杂种，种植地为广西南宁，单行单株种植，行长5米，株距25厘米，每行种植20株，田间水肥管理比当地水平稍高，F1代单株自交获得种子用于构建PHW52×S313F2分离群体；其中玉米材料S313是高抗南方锈病的广西农业科学院玉米研究所自有苏湾硬粒综合种自交分离多代选育出的抗性自交系，抗病鉴定实验表明，S313对取自广西多个地区玉米地的南方锈病病原菌具有高抗特性田间农艺性状稳定整齐，适合作为新品种选育的亲本材料；
2017年秋季，种植6705株F2(S313×PHW52)大群体，抽雄前对所有单株叶片取样，-80℃低温保存，在F2单株玉米抽雄期、抽雄期后7d和抽雄期后14d分3个时期对全部植株进行玉米南方锈病病原菌喷洒接种，所用玉米南方锈病病原菌来自于广西农业科学院明阳基地，在应季种植的高感玉米南方锈病品种活体植株叶片上采集，3次病原菌喷洒接种后鉴定记载各单株抗病性，取出各单株叶片进行DNA提取。
2、南方锈病抗性测量
乳熟后期进行玉米南方锈病调查，记载发病级别。病情分级标准：对每个单株进行1、3、5、7、9级的抗性评价，对亲本材料和群体中的每个家系通过加权平均计算该家系的抗性级别。病情分级标准：
1级：全株叶片无病斑或仅有无孢子堆的过敏性反应；
3级：全株叶片有少量孢子堆，占总叶面积少于等于25％；
5级：全株叶片有中量孢子堆，占总叶面积26～50％；
7级：全株叶片有大量孢子堆，占总叶面积51～75％；
9级：全株叶片有大量孢子堆，占总叶面积少于76～100％，叶片枯死。
3、SNP基因分型和分子标记
对182株的(S313×PHW52)F2群体进行KASP标记分型，所得碱基型数据如与S313相同，编码为“a”，与PHW52相同则编码为“b”，杂合型碱基编码为“h”，缺失数据编码为“-”。数据编码完毕后以TXT文本格式保存并导入Joinmap 4.0软件中。在Joinmap4.0软件界面首先用Grouping命令对所有标记进行分群；再对各个群用Calculate Linkage命令分别进行连锁计算；构建局部遗传连锁图。分群、遗传作图均采用极大似然估计(MaximumLikelihood),用Kosambi函数计算标记间遗传距离，经3轮排序优化获得最终的遗传标记图谱结果。4、QTL定位
首先把上述“a、b、h”型的分型数据相应转码成“A、B、H”数据，缺失数据编码为“-”保持不变。然后把这些“A、B、H”数据及上述计算获得的遗传图标记位置信息加上表型数据按软件QTL.gCIMapping.GUI1.1版本的格式要求整理保存在“EXCEL”格式文件(2006版本)后导入软件QTL.gCIMapping.GUI1.1中。在软件主界面中参数选择如下：(1)模型：随机模型；(2)染色体步移速度(walk speed)设为：1cM/次，(3)似然函数：ML(极大似然估计)；(4)CIM法：采用完全邻域复合区间作图法(CCIM)；(5)QTL检测阈值：采用软件默认值2.5。
5、候选基因筛选
利用maizeGDB网站查询1.52M-1.71M定位区间的所有基因信息，发现所在区间共有20个基因(部分基因位置相互重叠)，各基因名称、位置如下表：
表1 10染色体定位区间内基因汇总表
| 基因名称 | 位置 | 功能 |
| LOC103640666 | 1562448-1564208 | protein_coding，probable sugar phosphate/phosphate translocator |
| Zm00001d023261 | 1562714-1563865 | protein_coding |
| Zm00001d023262 | 1565392-1599381 | protein_coding，split over several different genes. |
| LOC100502470 | 1565428-1588766 | protein_coding，uncharacterized LOC100502470 |
| LOC103640668 | 1591206-1592377 | protein_coding，uncharacterized LOC103640668 |
| LOC103640667 | 1592515-1594555 | pseudo，uncharacterized LOC103640667 |
| Zm00001d023263 | 1592479-1594283 | protein_coding |
| LOC103640669 | 1594346-1600360 | protein_coding，protein ROOT PRIMORDIUM DEFECTIVE 1-like |
| Zm00001d023264 | 1600459-1605134 | protein_coding |
| LOC100383460 | 1600474-1605134 | protein_coding，Aladin |
| Zm00001d023265 | 1606001-1612705 | protein_coding |
| cl32328_1(710) | 1606001-1612666 | protein_coding，uncharacterized LOC100381533 |
| LOC103640671 | 1670026-1671879) | protein_coding，Aladin |
| Zm00001d023266 | 1670707-1671857 | protein_coding |
| Zm00001d023267 | 1680751-1687113 | protein_coding |
| <u>LOC103640673</u> | <u>1680843-1687157</u> | protein_coding，putative disease resistance RPP13-like protein 3 |
| Zm00001d023268 | 1689570-1689643 | tRNA |
| LOC103640674 | 1693603-1694500 | ncRNA，uncharacterized LOC103640674 |
| LOC100286374 | 1698116-1699066 | protein coding，VQ |
| Zm00001d023269 | 1698336-1698995 | protein_coding |
从表1可以看出，与抗性有关的候选基因只有1个：LOC103640673，位置在1680843-1687157，碱基序列如SEQ ID NO.1所示，其编码1个与RPP13类似的抗病蛋白，该蛋白的氨基酸序列如SEQ ID NO.2所示。
6、10染色体遗传图谱构建及QTL定位
182个单株F2群体10染色体遗传图谱见图1，从图1中可以看出，151个标记总的遗传距离为959.1cM，标记间平均距离为6.35cM，10-16360116与10-16504418间距离最短，为0.28cM，10-7920794与10-9910233间距离最长，为24.8cM。遗传图谱中除了少数标记如10-1448521等标记外，大部分标记的遗传距离与其在参考基因组B73上的真实物理距离相差不大，说明两个双亲在这些标记区段上与B73有良好的共线性。
玉米南方锈病主效QTL定位图见图2，玉米南方锈病QTL定位位置、效应表见表2，从图2、表2中可以看出，主效QTL的峰值被定位在标记10-1523544与标记10-1712625之间，LOD值为65.3，能解释表型变异的49.6％，区间大小约200K。
综上所述，可以确定在玉米第10号染色体的短臂上，在SNP标记10-1523544与标记10-1712625之间，存在一个影响玉米南方锈病抗性的主效QTL，LOD值为65.3，能解释表型变异的49.6％，区间大小约200K。
表2玉米南方锈病抗性QTL定位区间及效应表
7、候选基因的筛选
对步骤6所述的玉米第10号染色体短臂上标记10-1523544与标记10-1712625之间，区间大小为200K的区域进行注释分析，发现1个与抗性有关的候选基因:LOC103640673，碱基序列如SEQ ID NO.1所示，LOC103640673编码1个与抗病基因RPP13类似的蛋白，，该蛋白的氨基酸序列如SEQ ID NO.2所示，而前人的研究已表明在拟南芥中RPP13是被发现的第1个霜霉病抗性基因。
以上显示了本发明的基本原理、主要特征及优点。本行业的技术人员应该了解，本发明不受上述实施例则的影响，上述例子只是说明本发明的基本原理，在一定的范围和前提下，本发明可以有各种变化及完善，这些变化及完善均落入本发明要求保护的范围内。
序列表
<110> 广西壮族自治区农业科学院玉米研究所
<120> 一个影响玉米南方锈病抗性的主效QTL及其应用
<130> zyws
<160> 2
<170> SIPOSequenceListing 1.0
<210> 1
<211> 6320
<212> DNA
<213> 一个影响玉米南方锈病抗性的主效QTL及其应用(Zea mays L.)
<400> 1
tcgagaattg ggttcacacc atacatatct caatccataa tgatcacttc atttaagcat 60
ttagagttca aatacaaaga taataccatc cttatctttc aagcaaatac acagcccatc 120
tcaggaaaga aaatggggga aaaaaataag tccacatggt cgtttccaag gaaatacatg 180
gcccgtgcca ttaaaagtac acttcacaca aaatcaacac aagatagttt cgagaaaata 240
tatgacagct tataaaaata gagactgata cagataacaa tgaactgcat cacttgggtc 300
cgtctccctc ttcaatgtga ttttagacta agaaccgtga atctaattaa caagccatgc 360
caatgcttct aatcatcttg ctgaacagga gctctctctt tggtacttaa acaactcacg 420
tttacctgaa atattgattt gtgtatatag tagataagat gaaatgcaaa ggatggagca 480
accatgtaaa ggaaaaaatg caatcacaga atttcttcaa gaaaagagta atgatacact 540
tttttttggc caataaacat gtctaaccca aaacgattca gtttcgcaaa agcactatta 600
caaggttaaa acatgagctg ccatccacgt atatgatata tttgtttgtc ttggcgcttt 660
gtttggttcc tttcacctaa aatcatctca ggacctatca gaccagttaa cttgttagca 720
tttattttat aaatattagc acacttttta ccagggtacc ataagcaaat tggtttgatt 780
agcatacatg gtgcatttta gttggttagc tgttcaacac aagtaatata tgaatcagct 840
tttgtaccaa accttgatgt ctgctaactg aaatgggaac caaattagct taaaaagtat 900
ttggaaactt tgtttcaaaa gaaaagaaat aaactacatg aagaataaca ctgctcctgg 960
tcctgatgga tttacagtaa aaaaaataag cctttgtggc atctgatagg aggtgacatc 1020
aagaaaatgt tatgatatgc ggacaaacta gaactatgga gttattatac taattcctaa 1080
gatcaaacca gccacctcta ttagacaata tagaattctt tgtttactga atttgatcta 1140
taagatcatt actaaagtgc ttactgtgag gttaacaatt atagcagata aagtgataag 1200
cacataccag acagcttttg caagatgtct ccatgagtta agagctacaa aggtttctgg 1260
aattatttta aggcttgatt tttgagaggg cgtaagataa tgtaaattgg aactttttgg 1320
acgaggttct tcaaagaaaa ggtttttttt ctaatatatg gacaggttgg accagacagg 1380
cagttcagga ggacactagc tattgatttg aatggtgaaa gaggtgacta tttcagaagt 1440
tttaaaggtc tgagggattc tctttcccct ttattgttca acttagtgac agatgcttta 1500
tctgcccttc ttactagagc tagtagaggt tgtctgctaa agggcttaat ttcagagtta 1560
gttgatggag gtctaaccca cttgcaatat gctgatgata caatcatttt ttttaacaga 1620
actcaaaaga taacatgaac aatattaagg ctgatttggt ggacagggat catgattgga 1680
tccataagaa ggaatcccct tgctattcaa ttttaaatag caagggaatt cctcccccat 1740
agatcccctt gtgatcccta tcccccaaat cagcccttga gttattttat cttgttatga 1800
tgcaatgtca tggatgaaaa tcaactttga gaagtgttaa gtttttgttg ttgggactaa 1860
ggaccaggag aaagagagga tagctaaact tcttcattgc aaggtgggaa cttttcctat 1920
caaatatttg aagattcctg tgagtgacta aagcacagtt gaaataagta agtgacaaga 1980
ctcagaagag gttgggtact tggcagtgtg aatatctatc ttctggaggg aaatctactc 2040
taattgaatc ctgcctgtca atcattccta tttacacaat gggggtctat cacttgtatg 2100
aagggaattt ccagatgcta gactcgatca gatctttttt tatggaacta gcaagaaaag 2160
gaagtatcac atgacaggtg ggaggctcta aacagaccca aggagtttgg aggtttaggc 2220
ttcatggagg ttagagctat gattgtctgt ctcttggtga agtggacaga caaataatgg 2280
aggttataag caagagttga agatgcaaca attgcaagcg aaaaataagc aggtactaaa 2340
acttacacat ggcattggaa cgtgataact ggatagagta ataaaattaa tttttctggt 2400
tatcctttgg ttactgaact agttagctat ttttctgggt gctgttcttt ttttagaggt 2460
gttgcttagg tgttctgtcg agtggttggt ggctggtttg gctaaaatag ttagttctta 2520
gtgggctcct gataaagcca ggtgaaagcc tttgataatc taaaagaagg aaactgagcg 2580
tacatccggt aaccgaaaac tcatagagcg tctaccaaaa agctataggt gattatgttc 2640
tcaaatgaca atgcttgaaa ttttaagatg caacaactcc aagagaaaaa gagatgcttg 2700
aaattttaag atgcaacaaa tgcaagcgaa acagagaaca tagcaagaaa ctgaaactta 2760
cacatggcac agaatcgtga gaactggata gagtaataaa attaatttgg agtgtatatg 2820
gacatgcaca cgtacctgct gctgggttgg aaggaatgaa aaaaacatgt catcaattcc 2880
tgagctggag ttcggaaatg aaaaatatac gctagtggta agttgtaccc acaaagctaa 2940
ggtttccatt aactactgaa aaaagaaaat tccaagcagc taggacgaac ctctgtgttg 3000
ggatggtcag atgaggagga ggccattccg tcggtgtttg ttctgataag ttcgatactt 3060
ggatggttcg gatgaacctc ggctgcatgt ctataagctg cttccacttt ctgaacctca 3120
cacatgctgg cacccgaaca gtcgatgaaa ataatggctt tctgaagatg tcgatacatc 3180
cgcagctggc tgatgaagaa agcatcagat ttatccttca tcgtgcgcac gcagcaatcc 3240
cgttcaatct gtcgcagaag ctgagaaatg cagtacacaa acatattcaa agagaacagc 3300
ctcaccagag cctcccagtc ttcgtcggat aggatatttt cttcatatgc tcgaaccatt 3360
tttatggttg gacggttggc atgattttcc acagcacgca tgaccacggc ctccacctcc 3420
tccacttgtg cggcagtagc acctaagcag ttgactttga ctattacttg ctgaagtaaa 3480
aggacgttat ccaggtccaa gtgaagatct tcgatcacat ccttcgttgg gaactgctcg 3540
aacggcacac aaactccaaa tcgcagcact tcaagccttg gcatggcgcc cttacgaaac 3600
tcgaacgttg tgcccacttc gcagaacctc agattcctga agtcgtctgg gccaacagta 3660
taccttggag gaaagctgag accaaatagc tggaggtact ggagctctgg caacctcgct 3720
agattatcta ggtcctgtgc ttcaagagcg tgtaccctca gagataagaa gctgaggcgt 3780
gtcaggcagg agcggttgat ccatcgaggc tgccgtgaga agtcgatgcc ttcaataatc 3840
aggcgccgga gctgccttgg tggctcccag tctccccaca tatcgcttcc ccgctctggc 3900
attttacaca aaagctctag ttcctggagt cgccgcagat tggacagaga ttgcaccaat 3960
gcttcttgca agctctcctc tagctgctct gaaaaggtga tcctgaccac cctcaacctc 4020
gtcagcttgc caaactctgc cactaggtct tgggtggcac tccggccaac taccctattt 4080
agttgtagct cctccaggga cgttaggttc cccatcctat cagctggcaa cctttcgaag 4140
ccataggcta tcagacacat gagccgtgta agcgagcaaa gagccggtgg cagctcgtct 4200
agtccagtac ggactaatat cagtgtctga agagacctca gatgcccaat ttccttaggg 4260
agctcatcaa taggcgtgta tactatctct aggaacttga gatgcaacag cttccccaga 4320
tgctttaggc tgatgggtac gtagttgttt actatagaca gcacacggca aaccctgaag 4380
ctatcaattg gggccacaac cgcaatatta caatatataa tgttaagtga cctcaacacc 4440
tctggcatgt ccatggtgtc ttcagagaag cgttgcacac gttgatttcg gacagccagt 4500
cggcgtagct tgcagtctga ccgcagattg aacagagatt gcagtgactg agatgaatgt 4560
tgcccgctaa gggtaatgaa gtcttcatct ttcgacaact tacagatgag atcaaacaca 4620
atgtcatgaa tacagaacat ttgtgcagac cgattatatc tatcctctat cggctggatc 4680
atgcttctat tcacaagctc cttgaagtat ctttccccaa cctcaaatag gctaccctcc 4740
tctttctcaa gatggactag accttcacct atccacatcc atatcgcaac ttttgtatca 4800
aagagatagt cttctggaaa tatgcttagt tgcagcagac atggcttgag ataaggtggc 4860
aaatcatagt agctaaatga cattatcttt gttgtattgt ctccattccc aagaccaatc 4920
gagtcataca ctgttgacca ctcctcacat ggtatttcat ccaacaaact agctattgca 4980
atgatagcca atggtatgcc accacattta tgtatgattt tactagacag ttcaccatca 5040
aggctttctc cttcctcact ctctattctt ttgtagaata atttcttgga gttttcaatg 5100
gaaagaggtt ttaatctgta aacttcttcc actttcttga caaacccaga attgcgagta 5160
gtcatgatta ttctacttcc acaactattg tcctttaagg catatttgat cgcttcccat 5220
gagtcaacat cccatatgtc atcaacaacg atcaagtacc tatatataat tgacacaaga 5280
gtgtacagct atgaataact tggcaaatta attggtcgcc atatatataa agctataaac 5340
atttgaacta aaactagagg gagaatgaat gacatgggcg tacctcttgt ccttcaagaa 5400
ttcatccagt tcgtttataa attgttctag atcccatctg gccatgtcaa cttgtttata 5460
ctcacgatcg agttccaata gcatcttctc gaatgtccta ttcagattag gagttctacc 5520
aatagaaata aaagcagaac agtcgaattg cttcttaagc atgtcatgca ctgttttggc 5580
tagagtagtc ttacctagtc ctccaacccc gactatagac actatcttta gatcctgatg 5640
gaactcatgt gcatcttcat ctttggcccc tatagacagc atcctaatga ctttgtccct 5700
tgactcctcg ataccaacga gatctgtctc tttcttgtac agattgatga cacgggtgtc 5760
gatgccggtg ctcgcggcga gatcagcacc cacacccctt accgtgtact tggcacgaag 5820
ttcagctaac tcgttggaga gtttcttgat gtctttgacc ttgtcggaga tctggcaccg 5880
atccttgaac ttcttcatcg acatcacgtc cttgaccatg gcaagggtct tcttgaagaa 5940
tttggagtcg gcggcagagt cgtcaccacc agccacacgc aggatgaaat cgtcaacggc 6000
atcctccatg tcatacgaca gctcacggac ctggcgtgcc cagagctttt ccacctcggt 6060
gagctggtca tgtggaaccc gggacgcatc gacgagggcg gcgttcatca tcacgagctc 6120
cctggagagg gactcgatgt cgggcttgag gcccttctgc acgacatact tgtccatgag 6180
caggtcgccc agcttggggg ccaagctggt catggccccc aaggcgagct ccatgcctca 6240
ccagctggac cttctgtttc tcttgctaat tgcttggtac ctgctcgttg ggtgcagata 6300
tattataggt gagagtgaga 6320
<210> 2
<211> 1043
<212> PRT
<213> 一个影响玉米南方锈病抗性的主效QTL及其应用(Zea mays L.)
<400> 2
Met Glu Leu Ala Leu Gly Ala Met Ala Ser Leu Ala Pro Lys Leu Gly
1 5 10 15
Asp Leu Leu Met Glu Glu Tyr Val Val Gln Lys Gly Leu Lys Pro Asp
20 25 30
Ile Glu Ser Leu Ser Arg Glu Leu Val Met Met Asn Ala Ala Leu Val
35 40 45
Asp Ala Ser Arg Val Pro Pro Asp Gln Leu Thr Glu Val Glu Lys Leu
50 55 60
Trp Ala Arg Lys Val Arg Asp Leu Ser Tyr Asp Met Glu Asp Ala Val
65 70 75 80
Asp Asp Phe Ile Leu Arg Val Ala Gly Gly Asp Asp Ser Ala Asp Asp
85 90 95
Ser Lys Phe Phe Lys Lys Thr Leu Ala Thr Val Lys Asp Val Met Ser
100 105 110
Met Lys Lys Phe Lys Asp Arg Arg Gln Ile Ser Asp Lys Val Lys Asp
115 120 125
Ile Lys Lys Leu Ser Asn Glu Leu Ala Glu Leu Arg Ala Lys Tyr Thr
130 135 140
Val Arg Gly Val Gly Ala Asp Leu Ala Ala Ser Thr Gly Ile Asp Pro
145 150 155 160
Arg Val Ile Asn Leu Tyr Lys Lys Glu Thr Asp Leu Val Gly Ile Glu
165 170 175
Glu Ser Arg Asp Lys Val Ile Arg Met Leu Ser Met Gly Thr Lys Asp
180 185 190
Asp Asp Ala His Glu Ser His Gln Asp Leu Lys Ile Val Ser Ile Val
195 200 205
Gly Val Gly Gly Leu Gly Lys Thr Thr Leu Ala Lys Thr Val His Asp
210 215 220
Met Leu Lys Lys Gln Phe Asp Cys Ser Ala Phe Ile Ser Ile Gly Arg
225 230 235 240
Thr Pro Asn Leu Asn Arg Thr Phe Glu Lys Met Leu Leu Glu Leu Asp
245 250 255
Arg Glu His Lys Gln Val Asp Met Ala Arg Trp Asp Leu Glu Gln Phe
260 265 270
Lys Asn Glu Leu Asp Glu Phe Leu Lys Asp Lys Arg Tyr Leu Ile Val
275 280 285
Val Asp Asp Ile Trp Asp Val Asp Ser Trp Glu Ala Ile Arg Tyr Val
290 295 300
Leu Lys Asp Asn Asn Cys Gly Ser Arg Ile Ile Met Thr Thr Arg Asn
305 310 315 320
Ser Gly Val Val Thr Lys Val Glu Glu Val Tyr Arg Leu Lys Pro Leu
325 330 335
Ser Thr Glu Asn Ser Glu Lys Leu Phe Tyr Lys Arg Ile Glu Ser Gln
340 345 350
Glu Gly Glu Ser Leu Asp Gly Glu Leu Ser Ser Lys Ile Ile His Lys
355 360 365
Cys Gly Gly Ile Pro Leu Ala Ile Ile Ala Ile Ala Ser Leu Leu Val
370 375 380
Glu Arg Ser Arg Glu Glu Trp Pro Glu Val Tyr Asp Lys Ile Gly Leu
385 390 395 400
Gly Asn Glu Asp Asn Thr Thr Lys Ile Met Leu Tyr Ser Tyr Tyr Asp
405 410 415
Leu Pro Pro Tyr Leu Lys Pro Cys Leu Leu Gln Leu Ser Ile Phe Pro
420 425 430
Glu Asp Cys Phe Ile Asp Thr Lys Ala Val Ile Trp Met Trp Ile Gly
435 440 445
Glu Gly Leu Val His Leu Glu Lys Glu Glu Gly Ser Leu Phe Glu Val
450 455 460
Gly Glu Arg Tyr Phe Lys Glu Leu Val Asn Arg Ser Met Ile Gln Pro
465 470 475 480
Ile Glu Glu Lys Tyr His Trp Phe Val Glu Arg Phe Cys Ile His Asp
485 490 495
Ile Met Phe Asp Leu Ile Cys Lys Leu Ser Lys Asp Glu Asp Phe Ile
500 505 510
Thr Leu Ser Gly Gln His Ser Ser Gln Ser Leu Gln Ser Leu Phe Asn
515 520 525
Leu Arg Ser Asp Cys Lys Leu Arg Arg Leu Ala Val Arg Asn Gln Arg
530 535 540
Val Gln Arg Phe Pro Glu Glu Thr Met Asp Met Pro Glu Val Leu Arg
545 550 555 560
Ser Leu Ser Ile Ile Asp Cys Asn Ile Glu Val Met Ala Pro Ile Asp
565 570 575
Ser Phe Arg Val Cys Arg Val Leu His Ile Glu Asn Asn Tyr Val Pro
580 585 590
Ile Ser Leu Lys His Leu Gly Lys Leu Leu His Leu Lys Phe Leu Glu
595 600 605
Ile Phe Asp Thr Thr Ile Asp Glu Leu Pro Arg Glu Ile Gly His Leu
610 615 620
Arg Ser Leu Gln Thr Leu Val Leu Val Ser Thr Gly Leu Asp Glu Leu
625 630 635 640
Pro Val Ala Val Cys Ser Leu Thr Arg Leu Met Cys Leu Ile Ala Tyr
645 650 655
Gly Phe Glu Arg Leu Pro Ala Asp Arg Ile Gly Asn Leu Thr Ser Leu
660 665 670
Glu Glu Leu Gln Leu His Arg Val Val Gly Arg Ser Ala Thr Gln Asp
675 680 685
Leu Val Ala Glu Leu Gly Lys Leu Thr Arg Leu Arg Val Val Arg Ile
690 695 700
Thr Phe Ser Glu Gln Leu Glu Glu Ser Ser Gln Glu Ala Leu Val Gln
705 710 715 720
Ser Leu Ser Asn Leu Arg Leu Leu Gln Glu Leu Val Leu Phe Ser Glu
725 730 735
Met Pro Glu Arg Gly Ser Asp Met Trp Gly Asp Trp Glu Leu Pro Arg
740 745 750
Gln Leu Arg Arg Leu Ile Ile Glu Gly Ile Val Phe Ser Arg Gln Pro
755 760 765
Arg Trp Ile Asn Arg Ser Cys Leu Pro Arg Leu Tyr Ser Leu Tyr Leu
770 775 780
Met Val His Ala Val Glu Ala Gln Asp Leu Asp Asn Leu Ala Arg Leu
785 790 795 800
Pro Glu Leu Gln Tyr Leu Met Leu Phe Gly Phe Ser Trp Pro Pro Arg
805 810 815
Tyr Thr Val Gly Pro Asp Asp Phe Arg Asn Leu Arg Phe Cys Glu Val
820 825 830
Gly Thr Thr Phe Glu Phe Arg Lys Gly Ala Met Pro Arg Leu Glu Val
835 840 845
Leu Arg Phe Gly Val Cys Val Pro Phe Glu Gln Phe Pro Thr Lys Asp
850 855 860
Val Ile Glu Asp Leu Asp Phe Asp Leu Asp Asn Val Ile Leu Leu Gln
865 870 875 880
Gln Val Arg Val Lys Val Asn Cys Ala Gly Ala Thr Val Thr Gln Val
885 890 895
Glu Glu Val Glu Ala Val Val Met Arg Ala Val Glu Asn His Ala Asn
900 905 910
Arg Pro Thr Ile Lys Met Asp Arg Val Tyr Glu Gln Asn Ile Leu Ser
915 920 925
Asp Glu Glu Arg Glu Ala Leu Val Arg Leu Phe Ser Leu Asn Met Phe
930 935 940
Val Tyr Phe Asn Ser Gln Leu Gln Arg His Ile Glu Lys Asp Cys Cys
945 950 955 960
Val Arg Thr Met Lys Asp Lys Ser Asp Ala Phe Phe Ile Ser Gln Leu
965 970 975
Arg Arg Tyr Arg His Leu Gln Lys Ala Ile Ile Phe Ile Asp Cys Ser
980 985 990
Gly Ala Ser Met Cys Glu Val Gln Lys Val Glu Ala Ala Tyr Arg His
995 1000 1005
Ala Ala Glu Val His Pro Asn His Pro Ser Ile Glu Leu Ile Arg Thr
1010 1015 1020
Asn Thr Asp Gly Met Ala Ser Ser Ser Ser Asp His Pro Asn Thr Glu
1025 1030 1035 1040
Pro Arg Asn
Claims (6)
1.一个影响玉米南方锈病抗性的主效QTL，其特征在于：所述主效QTL位于第10号染色体的短臂上，在标记10-1523544与标记10-1712625之间。
2.按照权利要求1所述的影响玉米南方锈病抗性的主效QTL，其特征在于：所述主效QTL位点存在一个主效候选基因LOC103640673，其编码1个与抗病基因RPP13类似的蛋白，而RPP13是拟南芥中发现的1个霜霉病抗性基因。
3.按照权利要求1所述的的影响玉米南方锈病抗性的主效QTL，其特征在于：所述主效候选基因LOC103640673的碱基序列如SEQ ID NO.1所示，其编码的蛋白的氨基酸序列如SEQID NO.2所示。
4.按照权利要求1所述的所述的影响玉米南方锈病抗性的主效QTL，其特征在于：所述主效QTL位点对南方锈病抗性的表型变异解释率为49.6％。
5.按照权利要求1所述的所述的影响玉米南方锈病抗性的主效QTL，其特征在于：作图群体是由182株T2代组成的群体，其亲本的母本为PHW52，父本为抗玉米南方锈病S313；所述的主效QTL位点正向等位变异来自于S313。
6.权利要求1所述的影响玉米南方锈病抗性的主效QTL在玉米育种中应用。
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| CN114982630A (zh) * | 2022-05-06 | 2022-09-02 | 宿州学院 | 一种高抗南方锈病玉米的分子标记辅助育种方法 |
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| CN113372424A (zh) * | 2020-06-22 | 2021-09-10 | 北京市农林科学院 | 玉米南方锈病抗性基因及其应用 |
| CN113897352A (zh) * | 2020-06-22 | 2022-01-07 | 北京市农林科学院 | 玉米南方锈病抗性基因紧密连锁标记及其应用 |
| CN113897352B (zh) * | 2020-06-22 | 2023-06-23 | 北京市农林科学院 | 玉米南方锈病抗性基因紧密连锁标记及其应用 |
| CN114774573A (zh) * | 2022-04-20 | 2022-07-22 | 北京市农林科学院 | 与玉米南方锈病抗性相关的kasp标记及其应用 |
| CN114982630A (zh) * | 2022-05-06 | 2022-09-02 | 宿州学院 | 一种高抗南方锈病玉米的分子标记辅助育种方法 |
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