CN110549398A - Biological analysis method for detecting blood concentration of small molecule drug in antibody drug conjugate - Google Patents
Biological analysis method for detecting blood concentration of small molecule drug in antibody drug conjugate Download PDFInfo
- Publication number
- CN110549398A CN110549398A CN201810535241.4A CN201810535241A CN110549398A CN 110549398 A CN110549398 A CN 110549398A CN 201810535241 A CN201810535241 A CN 201810535241A CN 110549398 A CN110549398 A CN 110549398A
- Authority
- CN
- China
- Prior art keywords
- workbench
- blood concentration
- rotating shaft
- feeding device
- outer side
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D1/00—Cutting through work characterised by the nature or movement of the cutting member or particular materials not otherwise provided for; Apparatus or machines therefor; Cutting members therefor
- B26D1/0006—Cutting members therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D1/00—Cutting through work characterised by the nature or movement of the cutting member or particular materials not otherwise provided for; Apparatus or machines therefor; Cutting members therefor
- B26D1/01—Cutting through work characterised by the nature or movement of the cutting member or particular materials not otherwise provided for; Apparatus or machines therefor; Cutting members therefor involving a cutting member which does not travel with the work
- B26D1/12—Cutting through work characterised by the nature or movement of the cutting member or particular materials not otherwise provided for; Apparatus or machines therefor; Cutting members therefor involving a cutting member which does not travel with the work having a cutting member moving about an axis
- B26D1/25—Cutting through work characterised by the nature or movement of the cutting member or particular materials not otherwise provided for; Apparatus or machines therefor; Cutting members therefor involving a cutting member which does not travel with the work having a cutting member moving about an axis with a non-circular cutting member
- B26D1/34—Cutting through work characterised by the nature or movement of the cutting member or particular materials not otherwise provided for; Apparatus or machines therefor; Cutting members therefor involving a cutting member which does not travel with the work having a cutting member moving about an axis with a non-circular cutting member moving about an axis parallel to the line of cut
- B26D1/36—Cutting through work characterised by the nature or movement of the cutting member or particular materials not otherwise provided for; Apparatus or machines therefor; Cutting members therefor involving a cutting member which does not travel with the work having a cutting member moving about an axis with a non-circular cutting member moving about an axis parallel to the line of cut and rotating continuously in one direction during cutting, e.g. mounted on a rotary cylinder
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D7/00—Details of apparatus for cutting, cutting-out, stamping-out, punching, perforating, or severing by means other than cutting
- B26D7/06—Arrangements for feeding or delivering work of other than sheet, web, or filamentary form
- B26D7/0625—Arrangements for feeding or delivering work of other than sheet, web, or filamentary form by endless conveyors, e.g. belts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D7/00—Details of apparatus for cutting, cutting-out, stamping-out, punching, perforating, or severing by means other than cutting
- B26D7/22—Safety devices specially adapted for cutting machines
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D7/00—Details of apparatus for cutting, cutting-out, stamping-out, punching, perforating, or severing by means other than cutting
- B26D7/27—Means for performing other operations combined with cutting
- B26D7/32—Means for performing other operations combined with cutting for conveying or stacking cut product
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
- F16F15/00—Suppression of vibrations in systems; Means or arrangements for avoiding or reducing out-of-balance forces, e.g. due to motion
- F16F15/02—Suppression of vibrations of non-rotating, e.g. reciprocating systems; Suppression of vibrations of rotating systems by use of members not moving with the rotating systems
- F16F15/04—Suppression of vibrations of non-rotating, e.g. reciprocating systems; Suppression of vibrations of rotating systems by use of members not moving with the rotating systems using elastic means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D1/00—Cutting through work characterised by the nature or movement of the cutting member or particular materials not otherwise provided for; Apparatus or machines therefor; Cutting members therefor
- B26D1/0006—Cutting members therefor
- B26D2001/0033—Cutting members therefor assembled from multiple blades
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Forests & Forestry (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Aviation & Aerospace Engineering (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a biological analysis method for detecting blood concentration of small-molecule drugs in antibody drug conjugates, which comprises a workbench, wherein a feeding device is further arranged on the upper side of the workbench, a rotating shaft mounted on a hood is arranged above the feeding device, a roller is arranged on the outer side of the rotating shaft, a plurality of cutters are uniformly distributed on the outer side of the roller, a support column is arranged on the lower side of the workbench, a support plate is arranged at the lower end of the support column, a plurality of loop bars are arranged on the lower side of the support plate, telescopic rods are arranged at the lower ends of the loop bars, a base is arranged at the lower end of the telescopic rods, a damping spring is arranged on the outer side of the telescopic rods, a support rod is arranged at the right end of the upper side of the support plate, a cleaning box is arranged at the upper end of the support rod, a. The invention has simple structure, convenient use and good slicing effect, also has the cleaning function, improves the working efficiency and prolongs the service life of the device.
Description
Technical Field
The invention relates to the technical field of slicing devices, in particular to a bioanalysis method for detecting the blood concentration of a small-molecule drug in an antibody drug conjugate.
Background
The pharmaceutical industry and the biomedical engineering industry are two major pillars of the modern pharmaceutical industry. The biomedical industry is composed of both the biotechnology industry and the pharmaceutical industry. The definition and delineation of the biotechnology industry from country to country and from organization to organization is quite variable and often varies from person to person. Biomedical engineering is a principle and method of comprehensively applying life science and engineering science, and is a general term for understanding structures, functions and other life phenomena of human bodies at multiple levels in molecules, cells, tissues, organs and even the whole human body system from the engineering angle, researching artificial materials, products, devices and system technologies for preventing and treating diseases, assisting human body functions and health care, and in the research process of biomedicine, medicinal plants sometimes need to be sliced for the subsequent research process. The traditional slicing process comprises a manual guillotine type process, an automatic guillotine type slicing process and a horizontal or vertical disc type slicing process, which are all straight-cutting type processes. The slicing process has the following problems: the slice thickness of the medicinal materials is difficult to keep uniform; the slicing speed is limited, and the efficiency is not high enough; the slicing knife edge is easy to damage, and due to frequent friction of slices, the knife edge is overheated, and the medicinal properties of the traditional Chinese medicines are also influenced to a certain extent; most equipment knife edges are exposed outside, and the operation process is easy to cause accidental injury to people.
Disclosure of Invention
The invention aims to provide a bioanalysis method for detecting the blood concentration of a small-molecule drug in an antibody drug conjugate, so as to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
A bioanalysis method for detecting the blood concentration of micromolecular drugs in antibody drug conjugates comprises a workbench, wherein a hood is arranged on the upper side of the workbench, a feeding device is further arranged on the upper side of the workbench, a rotating shaft arranged on the hood is arranged above the feeding device, a roller is arranged on the outer side of the rotating shaft, a plurality of cutters are uniformly distributed on the outer side of the roller, a feeding port and a discharging port are respectively arranged on the left side and the right side of the hood, a support column is arranged on the lower side of the workbench, a support plate is arranged at the lower end of the support column, a plurality of loop bars are arranged on the lower side of the support plate, a telescopic rod is arranged at the lower end of the loop bar, a base is arranged at the lower end of the telescopic rod, a damping spring is arranged on the outer side of the telescopic rod, a support rod is arranged at the right end of the, be equipped with a plurality of stirring leaves on the (mixing) shaft, the upper end of wasing the case is equipped with the feeder hopper, is equipped with the play flitch of slope on the discharge gate, the lower extreme that goes out the flitch is located directly over the feeder hopper, washs the upper and lower both ends that have of case and is equipped with water inlet and outlet respectively, washs the left side lower extreme of case and is equipped with row material pipe.
As a further scheme of the invention: the upper end and the lower end of the damping spring are respectively connected with the lower side of the supporting plate and the upper side of the base.
As a still further scheme of the invention: the rotating shaft and the feeding device are both driven by a driving motor.
Compared with the prior art, the invention has the beneficial effects that: the rotary drum is arranged, the medicinal materials are sliced in a rolling cutting mode, the cut medicinal materials are uniform and flat, the slicing speed is high, the force of the medicinal materials on the knife edge is small during slicing, and the knife edge is not easy to damage; the mode friction time of hobbing is extremely short, and the edge of a knife generates little heat, and is little to the medicinal material influence, and equipment has still installed the aircraft bonnet additional, avoids personnel to be hindered by the roller mistake. Be equipped with the washing case, the medicinal material is directly can get into after the section is accomplished and wash the case, and it is convenient to wash, and the cleaning performance is good, can reduce subsequent work degree of difficulty, and save time improves the efficiency of work, is equipped with a plurality of telescopic links and damping spring, and the vibrations that the device during operation produced can disperse on a plurality of damping spring, and the shock attenuation is effectual, the vibrations that can reduce the device production, the production of noise abatement, the life of extension fixture.
Drawings
FIG. 1 is a schematic structural diagram of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1, in the embodiment of the present invention, a biological analysis method for detecting a blood concentration of a small molecule drug in an antibody drug conjugate includes a workbench 1, a hood 2 is disposed on an upper side of the workbench 1, a feeding device 3 is further disposed on an upper side of the workbench 1, a rotating shaft 4 mounted on the hood 2 is disposed above the feeding device 3, a roller 5 is disposed on an outer side of the rotating shaft 4, a plurality of cutters 6 are respectively disposed on outer sides of the roller 5, the rotating shaft 4 and the feeding device 3 are both driven by a driving motor, a rolling cutting manner is adopted to cut a drug into pieces, the cut drug pieces are uniform and flat, a slicing speed is high, a force applied to a knife edge by the drug is small, and the knife edge is not easily damaged; the mode friction time of hobbing is extremely short, and the edge of a knife generates little heat, and is little to the medicinal material influence, and equipment has still installed aircraft bonnet 2 additional, avoids personnel to be wounded by the roller by mistake. The left and right sides of aircraft bonnet 2 is equipped with feed inlet 7 and discharge gate 8 respectively, and the downside of workstation 1 is equipped with pillar 9, the lower extreme of pillar 9 is equipped with backup pad 10, the downside of backup pad 10 is equipped with a plurality of loop bars 11, the lower extreme of loop bar 11 is equipped with telescopic link 12, the lower extreme of telescopic link 12 is equipped with base 13, and the outside of telescopic link 12 is equipped with damping spring 14, damping spring 14's upper and lower both ends are connected with the downside of backup pad 10 and base 13's upside respectively, and the vibrations that the device during operation produced can disperse to a plurality of damping spring 14 on, and the shock attenuation is effectual, can reduce the vibrations that the device produced, the production of noise abatement, extension fixture's life.
The upside right-hand member of backup pad 10 is equipped with branch 15, the upper end of branch 15 is equipped with washs case 16, the lower extreme of wasing case 16 is equipped with agitator motor 19, agitator motor 19's output is equipped with installs at the inside (mixing) shaft 20 of wasing case 16, be equipped with a plurality of stirring leaves 21 on the (mixing) shaft 20, the upper end of wasing case 16 is equipped with feeder hopper 17, is equipped with the play flitch 18 of slope on the discharge gate 8, the lower extreme that goes out flitch 18 is located feeder hopper 17 directly over, washs the upper and lower both ends that have of case 16 and is equipped with water inlet 22 and outlet 23 respectively, and the left side lower. The medicinal material is directly can get into after the section is accomplished and washs 16, washs conveniently, and the cleaning performance is good, can reduce subsequent work degree of difficulty, and save time improves the efficiency of work.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (3)
1. A bioanalysis method for detecting the blood concentration of small-molecule drugs in antibody drug conjugates comprises a workbench and is characterized in that a hood is arranged on the upper side of the workbench, a feeding device is further arranged on the upper side of the workbench, a rotating shaft mounted on the hood is arranged above the feeding device, a roller is arranged on the outer side of the rotating shaft, a plurality of cutters are distributed on the outer side of the roller, a feed inlet and a discharge outlet are respectively arranged on the left side and the right side of the hood, a support column is arranged on the lower side of the workbench, a support plate is arranged at the lower end of the support column, a plurality of loop bars are arranged on the lower side of the support plate, a telescopic rod is arranged at the lower end of each loop bar, a base is arranged at the lower end of each telescopic rod, a damping spring is arranged on the outer side of each telescopic rod, a support rod is arranged at the right end of the upper, be equipped with a plurality of stirring leaves on the (mixing) shaft, the upper end of wasing the case is equipped with the feeder hopper, is equipped with the play flitch of slope on the discharge gate, the lower extreme that goes out the flitch is located directly over the feeder hopper, washs the upper and lower both ends that have of case and is equipped with water inlet and outlet respectively, washs the left side lower extreme of case and is equipped with row material pipe.
2. The bioanalysis method for detecting the blood concentration of a small molecule drug in an antibody drug conjugate as claimed in claim 1, wherein the upper and lower ends of the damping spring are respectively connected to the lower side of the supporting plate and the upper side of the base.
3. The bioanalytical method for detecting the blood concentration of small molecule drugs in antibody drug conjugates as claimed in claim 1, wherein the rotating shaft and the feeding device are both driven by a driving motor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810535241.4A CN110549398A (en) | 2018-05-30 | 2018-05-30 | Biological analysis method for detecting blood concentration of small molecule drug in antibody drug conjugate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810535241.4A CN110549398A (en) | 2018-05-30 | 2018-05-30 | Biological analysis method for detecting blood concentration of small molecule drug in antibody drug conjugate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110549398A true CN110549398A (en) | 2019-12-10 |
Family
ID=68735049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810535241.4A Pending CN110549398A (en) | 2018-05-30 | 2018-05-30 | Biological analysis method for detecting blood concentration of small molecule drug in antibody drug conjugate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110549398A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111530610A (en) * | 2020-05-13 | 2020-08-14 | 江苏杰森生物质能源科技有限公司 | Shock attenuation and noise reduction rubbing crusher for biological granule |
-
2018
- 2018-05-30 CN CN201810535241.4A patent/CN110549398A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111530610A (en) * | 2020-05-13 | 2020-08-14 | 江苏杰森生物质能源科技有限公司 | Shock attenuation and noise reduction rubbing crusher for biological granule |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110549398A (en) | Biological analysis method for detecting blood concentration of small molecule drug in antibody drug conjugate | |
| CN109393507A (en) | A kind of cleaning peeling slicing device for Chinese herbal medicine production | |
| CN210757923U (en) | Section equipment with adjustable traditional chinese medicine | |
| CN206011193U (en) | A kind of biological medicine research experiment auto slice device | |
| DE627969C (en) | Loosening and mixing device for rayon spinning solutions | |
| CN108297475A (en) | A kind of automatic preforming device of bio-pharmaceuticals convenient for discharging | |
| CN112657656B (en) | Raw and other materials reducing mechanism for bio-pharmaceuticals | |
| CN210675041U (en) | Medicine preparation apparatus for producing for biological medicine | |
| CN107414932B (en) | A kind of Chinese medicinal material slicing device | |
| DE202005012301U1 (en) | Fluidized bed batch dryer e.g. for heat sensitive biological materials, comprises a chamber with multiple vertical agitators providing overlapping agitation zones | |
| CN206982799U (en) | A kind of Chinese medicine cutting and making machine | |
| CN205412724U (en) | Agitating unit for bio -pharmaceuticals | |
| CN210585226U (en) | Multifunctional medicine cutting machine | |
| CN109807973A (en) | A kind of biological medicine research experiment auto slice device | |
| CN208509657U (en) | A kind of animal husbandry chopper for facilitating cutting herbage | |
| CN209679907U (en) | A kind of livestock-raising feed mixing device facilitating discharging | |
| CN109342149B (en) | Toxic substance detection equipment for fresh meat | |
| CN220313462U (en) | Traditional chinese medicine section device | |
| CN207678351U (en) | A kind of animal husbandry green grass grinding device | |
| CN210278469U (en) | Bio-pharmaceuticals separation purification filter equipment | |
| CN205435896U (en) | Human trace tissue sample mincer with sterilization function | |
| CN220308379U (en) | Dehairing device for processing fruit traditional Chinese medicines | |
| CN109530292A (en) | A kind of cleaning device for peeling for Chinese herbal medicine production | |
| CN109964663A (en) | A kind of animal husbandry Efficient Forage shredding mechanism | |
| CN216859826U (en) | Slicer for biological medicine research |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20191210 |
|
| WD01 | Invention patent application deemed withdrawn after publication |