CN110522667A - A kind of facial mask and its production technology by fibronectin attachment - Google Patents
A kind of facial mask and its production technology by fibronectin attachment Download PDFInfo
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- CN110522667A CN110522667A CN201910728925.0A CN201910728925A CN110522667A CN 110522667 A CN110522667 A CN 110522667A CN 201910728925 A CN201910728925 A CN 201910728925A CN 110522667 A CN110522667 A CN 110522667A
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- fibronectin
- mixed liquor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Nonwoven Fabrics (AREA)
Abstract
A kind of facial mask and its production technology by fibronectin attachment, the specific steps are as follows: 1) prepare the mixed liquor including following component: fibronectin, sea-mussel mucin, mannitol, sodium chloride, purified water；2) mixed liquor is stirred evenly；3) mixed liquor pH value 6.0-8.0 is adjusted；4) it is again stirring for uniformly, standing, for use；5) mask carriers are immersed in mixed liquor, is impregnated；6) it takes out, dries at room temperature, cutting packaging.Related biological principle of the present invention according to protein has bio-adhesive action characteristic using fibronectin, sea-mussel mucin, is attached in mask nonwoven fabric.The adhesive force of sea-mussel mucin is extremely strong, can become bonding medium, enhance the attachment of fibronectin and mask carriers.Mannitol therein plays a protective role to fibronectin, sea-mussel mucin as stabilizer, and sodium chloride plays the role of manufacturing physiological fluid environment.The facial mask has fine effect to maintenance nursing, the regeneration maintenance of skin.
Description
Technical field
The present invention relates to a kind of facial mask and its production technology by fibronectin attachment, specifically fibronectin and mussel is viscous
Albumen is attached to the production technology on mask carriers (non-woven fabrics, fibrous material, silk etc.), belongs to bioengineering related fields.
Background technique
Fibronectin (Fibronectin, FN) is a kind of macromolecule glycoprotein of adhesion, is widely present in animal tissue
In tissue fluid, there is multiple biological function.Fibronectin can execute multiple functions with many kinds of substance and cell combination.By
Have the characteristics that in fibronectin while being combined with each constituents of extracellular matrix, and can promote extracellular matrix other at
The deposition divided, it is believed that fibronectin is the organizer of extracellular matrix.Fibronectin wide participation cell migration, stick,
The processes such as proliferation, hemostasis and tissue repair transfer mononuclear phagocyte system and remove harmful substance at injury tissue, have growth
Factor effect.Its matrix as cell culture, can be improved the adherent rate of various kinds of cell, converges rate, shorten the cell confluency time,
Keep cellular prion protein good, metabolic rate enhancing, DNA, RNA and protein aggregate velocity significantly improve；The colony rate liter of cell
Height, originally culture survival rate improve.
Mussel be it is a kind of be distributed widely in coastal and coastal waters shell-fish marine organisms, byssus gland can secrete byssus, and
Mussel is fixed on various solid substrate surfaces by the byssus disk that byssus is formed.Studies have shown that the byssus of this and mussel secretion
Related, the main component of byssus is sea-mussel mucin (MAP), which has Ultrastrength adhesive ability.Researcher carries out MAP
Why amino acid structure analysis, discovery MAP have an extremely strong adhesive effect, what key was to be rich in its structure
DOPA, in addition the water-resistance of MAP is then replaced into 3,4 dihydroxyphenylalanines with its tyrosine residue, and then occur
The quinonyl oxidation of 3,4 dihydroxyphenylalanines is related.Sea-mussel mucin is because bonding range is wide, water-fast, speed is fast, corrosion-resistant, raw
Object compatibility is good, nonhazardous acts on, and human body will not be caused to generate immune response, have many advantages, such as wide spectrum adhesivity, solidifies
The film formed afterwards is transparent, ventilative, waterproof, flexible, can prevent the infringement of water and microorganism, therefore be widely used in biomedical neck
Domain.
Mask nonwoven fabric is a kind of non-woven cloth, it directly utilizes high polymer slice, staple fiber or long filament to pass through various fibres
The new type of fibrous product with a soft, breathable and planar structure that net manufacturing process and concretion technology are formed, its feature is not
Generate Soft flocks, feeling that is tough, durable, silky soft, having cotton.Soft feel when non-woven fabrics uses, and have good
Performance of keeping humidity, so in use, facial mask will not keep skin tight because of exsiccation.
Summary of the invention
The purpose of the present invention is exactly the biology adhesion properties using the above fibronectin and sea-mussel mucin, by fibre even egg
It is white to be attached on mask carriers (non-woven fabrics, fibrous material, silk etc.) with sea-mussel mucin.Fibronectin is glutinous in addition to itself having
Outside attached characteristic, moreover it is possible to it is adhered to the help of sea-mussel mucin with mask carriers (non-woven fabrics, fibrous material, silk etc.), because
The adhesive force of sea-mussel mucin is extremely strong, can become bonding medium, enhancing fibronectin and mask carriers (non-woven fabrics, fiber
Material, silk etc.) attachment.During practice principle, it is attached on mask carriers (non-woven fabrics, fibrous material, silk etc.)
Fibronectin is applied on skin after the dissolution of facial mask base fluid, has good effect to maintenance nursing, the regeneration maintenance of skin.
The purpose of the present invention is achieved through the following technical solutions:
A kind of facial mask adhered to by fibronectin, including carrier and the mask matrix solution being attached on carrier, in which: the face
Membrane matrix solution includes the ingredient of following weight percent: fibronectin 0.01-0.05%, sea-mussel mucin 0.005-
0.01%, mannitol 0.5-1.5%, sodium chloride 0.80-0.90%, surplus are purified water.
The carrier is the material that non-woven fabrics, fibrous material, silk etc. are suitable for adhering to solution.
The production craft step of facial mask of the present invention is specific as follows:
(1) prepare matrix mixed solution by the weight percent of following component substances: fibronectin 0.01-0.05%, mussel are viscous
Albumen 0.005-0.01%, mannitol 0.5-1.5%, sodium chloride 0.80-0.90%, surplus are purified water；
(2) mixed liquor is stirred evenly；
(3) pH value for adjusting mixed liquor is 6.0-8.0；Specifically with 50% hydrochloric acid solution or 40% sodium hydroxide solution tune
Save the pH value of mixed liquor.
(4) it is again stirring for uniform mixed liquor, is stood, for use；Time of repose is not less than 0.5 hour.
(5) carrier (non-woven fabrics, fibrous material, silk etc.) is completely immersed in mixed liquor, is impregnated；Soaking time is not less than
2 hours.
(6) carrier (non-woven fabrics, fibrous material, silk etc.) after impregnating is taken out, is dried at room temperature, cutting machine point is passed through
It cuts, packs.
When using product of the present invention, packaging is opened, takes out mask carriers (non-woven fabrics, fibrous material, silk etc.), is put in clean
Mask carriers are moistened in net water, then spread on face, dilutes and dissolves to fibronectin, absorbed by face skin.
The beneficial effects of the present invention are fibronectin is attached to mask carriers (non-woven fabrics, fibrous material, silk etc.)
Surface increases convenience and popularity that fibronectin uses.
In the present invention, fibronectin has the function of promoting cell growth, regeneration all kinds of problem skin of maintenance, even by fibre
Albumen is attached to mask carriers (non-woven fabrics, fibrous material, silk etc.) surface, for nursing skin, has good effect.It is fine
The effect case that even albumen is applied to regeneration all kinds of problem skin of maintenance is shown in Figure of description.
In the present invention, fibronectin can be attached to mask carriers (non-woven fabrics, undulation degree by the adhesion property of itself
Material, silk etc.) on, but in order to increase adhesion effect, it is added to sea-mussel mucin in the present invention, because of the bonding of sea-mussel mucin
It is very competent, bonding medium can be become, enhancing fibronectin is attached with mask carriers (non-woven fabrics, fibrous material, silk etc.)
.
In the present invention, stability of the mannitol as stabilizer protection fibronectin.Sodium chloride as physiological solution at
Divide substance, creates fibronectin and sea-mussel mucin plays itself adhesion characteristics, is adhered to mask carriers (non-woven fabrics, fibre
Tie up material, silk etc.) physiological environment needed for surface.
The technology of the present invention innovative point is as follows:
1, the technology of the present invention, which gives full play to fibronectin, can promote the effect of cell growth, regeneration all kinds of problem skin of maintenance,
And there are the biological characteristics of adhesion property using fibronectin, the application field of fibronectin is expanded, market visitor is met
The more extensive demand in family, is specifically for use in cosmetic mask market.
2, production technology simplicity specification of the present invention, strong applicability is, it can be achieved that industrially scalable metaplasia produces.Core functional component fibre connects
The production of protein raw materials is our patented technology, and other auxiliary materials are market conventional raw material, so exploitation this product can be realized
Good economic benefit and social benefit.
3, product of the present invention application method is simple and convenient, through on probation very popular with users, with the market demand potential.
Detailed description of the invention
Fig. 1 is fibronectin maintenance hormone face case diagram,
Fig. 2 is fibronectin maintenance red capillary case diagram,
Fig. 3 is fibronectin maintenance acne case diagram,
Fig. 4 is fibronectin maintenance sensitivity skin case diagram.
Specific embodiment
The present invention is described further with reference to embodiments:
Embodiment 1
(1) matrix mixed solution: fibronectin 0.01%, sea-mussel mucin is prepared by the weight percent of following component substances
0.005%, mannitol 1%, sodium chloride 0.85%, surplus are purified water；
(2) mixed liquor is stirred evenly；
It (3) is 6.0-8.0 with the pH value that 50% hydrochloric acid solution adjusts mixed liquor A；
(4) it is again stirring for uniform mixed liquor, stands 45 minutes, for use；
(5) non-woven fabrics for taking clean bundled wrapping, non-woven fabrics is completely immersed in mixed liquor, soaking time 2 hours；
(6) non-woven fabrics impregnated is taken out, dries, is cut by cutting machine at room temperature, is packed.
Embodiment 2
(1) matrix mixed solution: fibronectin 0.05%, sea-mussel mucin is prepared by the weight percent of following component substances
0.01%, mannitol 1.5%, sodium chloride 0.85%, surplus are purified water；
(2) mixed liquor is stirred evenly；
It (3) is 6.0-8.0 with the pH value that 40% sodium hydroxide solution adjusts mixed liquor A；
(4) it is again stirring for uniform mixed liquor, stands 2 hours, for use；
(5) fibrous material is taken, is completely immersed in mixed liquor, soaking time 3 hours；
(6) fibrous material impregnated is taken out, dries, is cut by cutting machine at room temperature, is packed.
Above-described embodiment is the description of the invention, is not limitation of the invention, after any pair of simple transformation of the present invention
Scheme all belong to the scope of protection of the present invention.
Application effect is applied to the effect of regeneration all kinds of problem skin of maintenance referring to fibronectin shown by Figure of description
Fruit case-control figure.
Claims (6)
1. a kind of facial mask adhered to by fibronectin, including carrier and the mask matrix solution being attached on carrier, feature exists
In: the mask matrix solution includes the ingredient of following weight percent: fibronectin 0.01-0.05%, sea-mussel mucin
0.005-0.01%, mannitol 0.5-1.5%, sodium chloride 0.80-0.90%, surplus are purified water.
2. the facial mask according to claim 1 adhered to by fibronectin, it is characterised in that: the carrier is non-woven fabrics, fibre
Tie up material, silk is suitable for adhering to the material of solution.
3. a kind of production technology of facial mask as described in claim 1, which is characterized in that specific step is as follows:
(1) prepare matrix mixed solution by the weight percent of following component substances: fibronectin 0.01-0.05%, mussel are viscous
Albumen 0.005-0.01%, mannitol 0.5-1.5%, sodium chloride 0.80-0.90%, surplus are purified water；
(2) mixed liquor is stirred evenly；
(3) pH value for adjusting mixed liquor is 6.0-8.0；
(4) it is again stirring for uniform mixed liquor, is stood, for use；
(5) carrier is completely immersed in mixed liquor, is impregnated；
(6) carrier after impregnating is taken out, dries, is cut by cutting machine at room temperature, is packed.
4. production technology according to claim 3, which is characterized in that it is characterized by: in step (3), with 50% salt
Acid solution or 40% sodium hydroxide solution adjust mixed liquor pH value be 6.0-8.0.
5. production technology according to claim 3, which is characterized in that it is characterized by: in step (4), time of repose
Not less than 0.5 hour.
6. production technology according to claim 3, which is characterized in that it is characterized by: in step (5), soaking time
Not less than 2 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910728925.0A CN110522667B (en) | 2019-08-08 | 2019-08-08 | Facial mask attached by fibronectin and production process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910728925.0A CN110522667B (en) | 2019-08-08 | 2019-08-08 | Facial mask attached by fibronectin and production process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110522667A true CN110522667A (en) | 2019-12-03 |
| CN110522667B CN110522667B (en) | 2022-06-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910728925.0A Active CN110522667B (en) | 2019-08-08 | 2019-08-08 | Facial mask attached by fibronectin and production process thereof |
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| Country | Link |
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| CN (1) | CN110522667B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111588650A (en) * | 2020-05-26 | 2020-08-28 | 合肥卡迪尔生物科技有限公司 | Repairing composition, repairing mask liquid and repairing mask |
| CN111671666A (en) * | 2020-06-23 | 2020-09-18 | 湖南美媛本草生物工程有限公司 | Preparation method and application of freeze-dried powder containing multi-effect restoration composition |
| CN114344174A (en) * | 2021-12-30 | 2022-04-15 | 美尔健（深圳）生物科技有限公司 | Mask prepared based on jellyfish collagen solution and preparation method thereof |
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| CN104983636A (en) * | 2015-07-15 | 2015-10-21 | 菏泽天鸿果蔬有限公司 | Peony acne removing and oil controlling mask and preparing method of peony acne removing and oil controlling mask |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111588650A (en) * | 2020-05-26 | 2020-08-28 | 合肥卡迪尔生物科技有限公司 | Repairing composition, repairing mask liquid and repairing mask |
| CN111588650B (en) * | 2020-05-26 | 2023-04-28 | 合肥卡迪尔生物科技有限公司 | Repairing composition, repairing mask liquid and repairing mask |
| CN111671666A (en) * | 2020-06-23 | 2020-09-18 | 湖南美媛本草生物工程有限公司 | Preparation method and application of freeze-dried powder containing multi-effect restoration composition |
| CN114344174A (en) * | 2021-12-30 | 2022-04-15 | 美尔健（深圳）生物科技有限公司 | Mask prepared based on jellyfish collagen solution and preparation method thereof |
| CN114344174B (en) * | 2021-12-30 | 2024-02-06 | 美尔健（深圳）生物科技有限公司 | Mask prepared based on jellyfish collagen solution and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN110522667B (en) | 2022-06-10 |
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Effective date of registration: 20230426 Address after: Room 202-07, No. 1, Lane 70, Haiji 6th Road, Lingang New Area, China (Shanghai) Free Trade Pilot Zone, Pudong New Area, Shanghai, 200120 Patentee after: Shanghai Xianlian Biotechnology Co.,Ltd. Address before: 450001 6th floor, building 93, No. 1, Cuizhu street, high tech Zone, Zhengzhou City, Henan Province Patentee before: Wang Bin |
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