CN110507843A - A kind of preparation method of degradable functional dressing - Google Patents
A kind of preparation method of degradable functional dressing Download PDFInfo
- Publication number
- CN110507843A CN110507843A CN201910874477.5A CN201910874477A CN110507843A CN 110507843 A CN110507843 A CN 110507843A CN 201910874477 A CN201910874477 A CN 201910874477A CN 110507843 A CN110507843 A CN 110507843A
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- Prior art keywords
- preparation
- kapok
- functional dressing
- electrostatic spinning
- drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
- D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
- D01D5/0038—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion the fibre formed by solvent evaporation, i.e. dry electro-spinning
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0069—Electro-spinning characterised by the electro-spinning apparatus characterised by the spinning section, e.g. capillary tube, protrusion or pin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
Abstract
The invention discloses a kind of preparation methods of degradable functional dressing, which is characterized in that makes nanofiber drug-loaded layer using electrostatic spinning technique；Kapok hydro-entangled non-woven fabric, i.e. liquid-adsorption layer is made through nonwovens process in natural antibacterial material kapok.Present invention process is simple, it is efficiently convenient, drug-loaded layer carries medicine polylactic acid nano fiber using electrostatic spinning process preparation, when fiber degradation or water-swellable chance, drug ingedient will be slow release, and bacterium and unwanted particles can be effectively obstructed, the good environment of a suitable tissue growth is caused, promotes tissue growth；The non-woven bombax cotton that liquid-adsorption layer uses, naturally, antibacterial, environmental protection.Nonwovens process produces kapok, the efficient productivity and excellent properties for retaining fibrinogen greatly improve production efficiency and properties of product.
Description
Technical field
The present invention relates to the preparation methods that a kind of natural degradable carries Types of Medicine medical dressing, belong to functional form medical dressing skill
Art field.
Background technique
With the raising of the growth of chronic wound care Problematic patients and social progress and people's quality of life, people
Requirement to Wound care products is also higher and higher.Dispoable medical dressing is the huge Wound care product of dosage, but at present
The traditional dressing used has the following problems: (1) tradition is temporary covering material, is both needed to be subject within a certain period of time more
It changes, and the easy adhesion wound in agglutination, causes secondary damage.(2) quickening wound is unable to satisfy without special medicinal function
The effect of healing.(3) limited wettability needs to frequently replace, and wastes a large amount of resource, pollutes environment.Therefore to dressing into
The functional raising with service performance of row is extremely important.
Summary of the invention
The technical problems to be solved by the present invention are: providing a kind of natural degradable, softness patch skin imbibition rate is high and has
The medical dressing of medicament slow release effect.
To solve the above-mentioned problems, the present invention provides a kind of preparation method of degradable functional dressing, features
It is, comprising the following steps:
Step 1): nanofiber drug-loaded layer is made using electrostatic spinning technique；
Step 2): kapok hydro-entangled non-woven fabric, i.e. liquid-adsorption layer is made through nonwovens process in natural antibacterial material kapok.
Preferably, in the step 1) spinning solution of electrostatic spinning technique process for preparation are as follows: by the poly- of mass fraction 2%
Lactic acid (PLA) is added in the mixed solution of chloroform and dimethylformamide (DMF), chloroform and dimethylformamide
Mass ratio be 10:2, with magnetic stirrer shake 48h, be made PLA solution；Again by externally applied anti-inflammation medicine with mass percent
10% ratio is dissolved in ethyl alcohol, is shaken 30min, is then added to the solution in PLA solution with the mass ratio of 1:10, is stirred
It mixes.
Preferably, in the step 1) electrostatic spinning technological parameter are as follows: penetrate flow rate pump be 10 μ L/min, syringe needle and receive
The distance between device is 25cm, and voltage 10kV, the spinning time is 10min；Specific steps are as follows: the spun lacing kapok felt that will be prepared
As base fabric is received, electrospun fibers are received；Heating up drying 24 hours after finishing receiving makes solvent volatilize completely.
Preferably, the grammes per square metre of kapok hydro-entangled non-woven fabric is 70-90g/m in the step 2)2, with a thickness of 0.15-0.5 milli
Rice.
Preferably, the drug-loaded layer and liquid-adsorption layer mutually bond, and are then cut into required specification, then seal, outer packing, most
After sterilized.
Drug-loaded layer carries medicine polylactic acid nano fiber using electrostatic spinning process preparation, when fiber degradation or water-swellable chance,
Drug ingedient will be slow release electrostatic spinning fiber film have the characteristics that as drug-loaded layer it is following: the absorption to wound tissue's liquid
Rate is high, and wound can be made to keep preferably wet degree；Semipermeability is conducive to the respiration of cell；It can effectively protect wound
Mouth is invaded from bacterium；Haemostatic effect is good, and large specific surface area can effectively improve the anthemorrhagic speed of wound；It is consistent with wound
Property, flexibility is good, can preferably protect wound；Such as various Porcine HGFs, medicine are added in functionality in electrostatic woven material
The biologically active molecule such as object, antibacterial agent, polypeptide；Environmental protection, using the Green biological materials such as polymer that can be degradable,
Its waste is easily handled, pollution abatement.
Non-woven kapok layer is used as liquid-adsorption layer, largely can quickly absorb wound blood and tissue fluid.Due to bombax cotton
It is most thin, most light, highest Fiber Materials of degree of hollowness and be renewable natural resources in natural ecological fiber, as
Dressing liquid-adsorption layer has a following feature: it is functional, have and absorb secretion, sweat, the functions such as heat preservation and antibacterial, do not need through
Normal more change dressings；Performance is excellent, obtains that product liquid absorbency rate is high, soft, permeability is good；Natural big cavity structure, can protect
Temperature promotes wound healing；Subjective antisepsis drives mite rate up to 87.54%, and bacteriostasis rate is 99% or more；It is high in machining efficiency, it is non-to knit
Make that technology is high in machining efficiency, production cost is low.
According to the functional medical dressing for the novel degradable that this method is prepared, there is anti-infective, promotion injected organism tissue
Growth, quick-acting haemostatic powder and the effect of promote wound healing；Have simultaneously and quickly absorb secretion, liquid absorbency rate is high, the spies such as heat preservation
Point, and product prepares material and is all made of natural degradable material, it is environment friendly and pollution-free.
Detailed description of the invention
Fig. 1 is the degradable preparation flow figure for carrying Types of Medicine functional dressing provided by the invention.
Specific embodiment
In order to make the present invention more obvious and understandable, hereby with preferred embodiment, and attached drawing is cooperated to be described in detail below.
Embodiment
A kind of degradable preparation method for carrying Types of Medicine functional dressing:
Step 1 prepares kapok liquid-adsorption layer and cotton surface layer, carries out needling non-woven work respectively to bombax cotton and cotton fiber
Skill processing, stock-blowing-combing-lapping-pre-needling → main needle pierces concrete technology stream as shown in Figure 1: -- dressing base fabric.Imbibition
Layer grammes per square metre is 80g/m2, cotton surface layer is 100g/m2。
Step 2 will weigh by weight prepare spinning solution at normal temperature, and 2% polylactic acid of mass fraction (PLA) is added
To in the mixed solution of chloroform and dimethylformamide (DMF), chloroform/dimethylformamide ratio is 10:2 magnetic
Power blender stirring concussion 48h.Externally applied anti-inflammation medicine is dissolved in ethyl alcohol with mass fraction 10% again, 30min is shaken, then should
Solution is added in PLA solution, and mixed proportion 1:10 is stirred and evenly mixed.
Step 3, it is 10 μ L/min that micro-injection flow rate pump, which is arranged, in electrostatic spinning, and the distance between syringe needle and receiver are
25cm, voltage 10kV, spinning time are 10min, using the above-mentioned spun lacing kapok felt prepared as base fabric is received, receive electrostatic
Spinning fibre.Heating up drying 24 hours after finishing receiving makes solvent volatilize completely.
Step 4: dressing surface layer is prepared finished product dressing with compound combined layer by layer of medicine imbibition is carried with hot pressure sensitive adhesive by bonding.
Step 5: being cut by different size, sealing and outer packing, and then carrying out sterilizing again becomes product.
Claims (5)
1. a kind of preparation method of degradable functional dressing, which comprises the following steps:
Step 1): nanofiber drug-loaded layer is made using electrostatic spinning technique；
Step 2): kapok hydro-entangled non-woven fabric, i.e. liquid-adsorption layer is made through nonwovens process in natural antibacterial material kapok.
2. the preparation method of degradable functional dressing as described in claim 1, which is characterized in that quiet in the step 1)
The process for preparation of the spinning solution of Electrospinning are as follows: the polylactic acid of mass fraction 2% is added to chloroform and dimethyl methyl
In the mixed solution of amide, the mass ratio of chloroform and dimethylformamide is 10:2, is shaken with magnetic stirrer
PLA solution is made in 48h；Externally applied anti-inflammation medicine is dissolved in ethyl alcohol with the ratio of mass percent 10% again, shakes 30min, then
The solution is added in PLA solution with the mass ratio of 1:10, is stirred and evenly mixed.
3. the preparation method of degradable functional dressing as claimed in claim 1 or 2, which is characterized in that the step 1)
The technological parameter of middle electrostatic spinning are as follows: penetrating flow rate pump is 10 μ L/min, and the distance between syringe needle and receiver are 25cm, and voltage is
10kV, spinning time are 10min；Specific steps are as follows: using the spun lacing kapok felt prepared as base fabric is received, receive electrostatic spinning
Fiber；Heating up drying 24 hours after finishing receiving makes solvent volatilize completely.
4. the preparation method of degradable functional dressing as described in claim 1, which is characterized in that wooden in the step 2)
The grammes per square metre of cotton hydro-entangled non-woven fabric is 70-90g/m2, with a thickness of 0.15-0.5 millimeters.
5. the preparation method of the degradable functional dressing as described in claim 1-4 any one, which is characterized in that described
Drug-loaded layer and liquid-adsorption layer mutually bond, and are then cut into required specification, then seal, outer packing, are finally sterilized.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910874477.5A CN110507843A (en) | 2019-09-17 | 2019-09-17 | A kind of preparation method of degradable functional dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910874477.5A CN110507843A (en) | 2019-09-17 | 2019-09-17 | A kind of preparation method of degradable functional dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110507843A true CN110507843A (en) | 2019-11-29 |
Family
ID=68632518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910874477.5A Pending CN110507843A (en) | 2019-09-17 | 2019-09-17 | A kind of preparation method of degradable functional dressing |
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| CN (1) | CN110507843A (en) |
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| CN103205862A (en) * | 2013-03-25 | 2013-07-17 | 蒋海彦 | Production method of kapok fiber spunlaced nonwoven fabric |
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2019
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Application publication date: 20191129 |
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