CN110507557A - Fat-soluble toothpaste - Google Patents
Fat-soluble toothpaste Download PDFInfo
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- CN110507557A CN110507557A CN201910890685.4A CN201910890685A CN110507557A CN 110507557 A CN110507557 A CN 110507557A CN 201910890685 A CN201910890685 A CN 201910890685A CN 110507557 A CN110507557 A CN 110507557A
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- fat
- soluble
- vitamin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of fat-soluble toothpaste.The fat-soluble toothpaste by mass percentage, is made of moisturizer 45%-60%, rubbing agent 10-20%, purificant 2-3%, adhesive 0.5-1.5%, sweetener 0.1-0.2%, preservative 0.1-0.2%, Ascorbyl Palmitate 0.5-1.5%, vitamin E 0.3-0.7%, vitamin B complex 5-10%, zinc gluconate 2-5%, water surplus.Fat-soluble toothpaste of the invention can remove oral inflammation, and cleanable tooth, reduce bleeding gums, and swelling and aching of gum repairs canker sore and firm tooth.
Description
Technical field
The present invention relates to a kind of formulation of tooth-paste, specifically a kind of fat-soluble formulation of tooth-paste.
Background technique
Toothpaste is a kind of preparation that auxiliary is brushed teeth, and can enhance the frictional force brushed teeth, and help removes food scraps, soft dirt, tooth
Bacterial plaque, facilitate eliminate and mitigate oral peculiar smell, with the improvement of people ' s living standards with the upgrading of consumption idea, oral cleaning
Articles also develop from cleaning to health-care hospital direction.
The disease incidence of mouth disease is very high in recent years, seriously affects the quality of life of crowd, dental caries early stage is to suffer from tooth to the cold
Thermo-responsive, pain, continuing development will appear a series of complication such as pulpitis, periapical inflammation, and periodontitis can cause gum red
Swollen, bleeding, tooth mobility.Periodontal cell film is periodontium important component, is a kind of group with Multidirectional Differentiation function
Body cell plays an important role in maintenance periodontium health.Toothpaste is all water-soluble in present society, and toothpaste is in oral cavity
Residence time is short, and effective component cannot act on periodontal cell film well.
Summary of the invention
It is water solubility for common toothpaste containing vitamin C currently on the market, in oral cavity, action time is short, it is not easy to inlet port
The shortcomings that chamber cell interior, the purpose of the present invention is to provide one kind can remove oral inflammation, and cleanable tooth, reduces tooth
Oulorrhagia, swelling and aching of gum repair the fat-soluble toothpaste of canker sore and firm tooth.
The technical solution adopted by the present invention is that: a kind of fat-soluble toothpaste is prepared from the following raw materials by mass percentage: being protected
Humectant 45%-60%, rubbing agent 10-20%, purificant 2-3%, adhesive 0.5-1.5%, sweetener 0.1-0.2%, anti-corrosion
Agent 0.1-0.2%, Ascorbyl Palmitate 0.5-1.5%, vitamin E 0.3-0.7%, vitamin B complex 5-10%, grape
Saccharic acid zinc 2-5%, water surplus.
Further, by mass percentage, it is prepared from the following raw materials: moisturizer 54.8%, rubbing agent 15%, purificant
2.5%, adhesive 1.0%, sweetener 0.15%, preservative 0.15%, Ascorbyl Palmitate 0.9%, vitamin
E0.5%, vitamin B complex 7%, zinc gluconate 3%, water surplus.
Further, the moisturizer is sorbierite and/or PEG-400.
Further, the rubbing agent is hydrated silica.
Further, the purificant is lauryl sodium sulfate.
Further, the adhesive is the combination of cellulose gum and xanthan gum.
Further, the sweetener is saccharin sodium.
Further, the preservative is sodium benzoate.
The beneficial effects of the present invention are:
1, fat-soluble toothpaste of the invention joined Ascorbyl Palmitate on the basis of ordinary toothpaste matrix.
Ascorbyl Palmitate (fat-soluble VC, abbreviation L-AP) has the oxidation effectiveness better than former ascorbic acid, due to palmitinic acid
It is connected on the 6- hydroxyl of ascorbic acid, has not only increased its stability, but also do not destroy secondly enol structure, itself has extremely strong anti-
Oxidisability, antioxidation and vitamin C in uniform system have identical effect, but in purificant dodecyl sulphate
Antioxidant activity is higher in sodium.Its principle is to give the compound free radical of hydrogen atom, itself forms free radical, and the latter can
Disproportionated reaction occurs, to eliminate free radical.
L-AP also has extremely strong biological anti-inflammatory simultaneously, can effective protection profitable strain, leukocytes phagocytic is thin in reinforcement
The ability of bacterium and virus mitigates human body feeling of pain because of caused by a variety of causes, prevents harmful infection, and quick healing of wound mentions
Rise detoxification ability.Since L-AP nanoscale size is close to the size of body molecule, just pass through the lipid of mucous membrane of mouth within several seconds
Cell membrane is directly entered human body cell, " is sustained " in the cell work (sustained release utility), be finally reached environment in daf molecule,
The effect of restoring each histiocytic execution function and information interchange.Meanwhile L-AP is special fat-soluble is easy to be inhaled by cell adipose membrane
It receives, the pH value of L-AP is quickly dissolved in blood, cell membrane and lipid, the fast 4-5 of speed ratio water solubility VC closer to pH value of human body
Times, more enter capilary and carries out reparation and the cleaning to blood.Utilize the particularity of L-AP, L-AP effective component inlet port
Chamber mucous membrane is quickly move through by the cutaneomucosal space between cells of table with its liposoluble characteristic, into cell interior, useful effect in
Inflammation part.It plays putrefaction-removing granulation-promoting and promotes meat dental tissue hyperplasia, improve surface of a wound microcirculation, repair oral mucosa damage tissue rapidly
Multiple, L-AP can participate in amino acid metabolism, and neurotransmitter synthesis reduces permeability, the lipid-loweringing removing toxic substances of capillary, stimulates oral cavity saliva
Liquid secretion improves lysozyme concentration, effectively sterilizes, improves and repair canker sore symptom.
L-AP uses ultra micro adipose capsule nanotechnology, ultra tiny levorotatory substance is coated in special nano-microcapsule film,
Nutrient is independent " sealing up for safekeeping ", with isolation from oxygen unstable factor caused by levorotatory substance, quickly through the cell of oral mucosa
Gap is directly entered human body cell, dissolves in blood, cell membrane and lipid.It can help to the collagen group of synthesis gum matrix
It knits, to have the function that firm tooth.
2, fat-soluble toothpaste of the invention joined vitamin B complex, vitamin B complex on the basis of ordinary toothpaste matrix
Containing vitamin B1, vitamin B2, vitamin B6, niacinamide and calcium pantothenate etc., internal sugar, amino acid and fatty generation may participate in
It thanks, while forming coenzyme, be chiefly used in disease caused by hypovitaminosis, wherein vitamin B2, which has, participates in body redox
Reaction promotes mucous membrane regeneration, protects the function of mucous membrane and sebaceous glands, can prevent the occurrence and development of angular stomatitis, cheilitis, glossitis.
Vitamin B2 also participates in the metabolism of carbohydrate, nucleic acid, fat, improves body to the utilization rate of protein, cell is promoted to increase
It is long, regeneration, ulcer healing.Furthermore vitamin B complex antioxidation also helps removing free radical, and anti-inflammatory and antalgic promotes
Ulcer healing.
3, fat-soluble toothpaste of the invention joined vitamin E (VE) on the basis of ordinary toothpaste matrix, and VE belongs to rouge
Soluble vitamin, it is not only related with body metabolism, tissue adherence reparation and cell normal function maintenance or important in vivo
Antioxidant, prevent the damage of free radical and the peroxidating of unsaturated fatty acid, alleviate ulcer surface pain and accelerate its be cured
It closes.
4, fat-soluble toothpaste of the invention joined zinc gluconate on the basis of ordinary toothpaste matrix, metal from
Sub- Zn2+In the presence of, zinc gluconate and O2Reaction, firstly generates H2O2And hydroascorbic acid, to eliminate O2Or H2O2To machine
The oxidative damage of body.Zinc is the constituent and activator of in-vivo metal enzyme, and zinc also participates in the synthesis, thin of DNA, RNA, protein
Born of the same parents' division and regeneration, can promote epithelial cell growth, accelerate ulcer healing.And normal immunological function can be maintained, induce T leaching
Bar cell activation activates bone-marrow-derived lymphocyte, participates in antibody and is formed and release, the nearly water of lipophilic, does not keep in dark place, is not afraid of tide, enhance to thin
Bacterium, viral resilience.Can effective prevention of gingivitis periodontitis generation.
Specific embodiment
Embodiment 1-4
One, fat-soluble toothpaste is made by the formula of table 1.
Two, preparation method: by the formula feeding of table 1, raw material is uniformly mixed, toothpaste making process routinely.
Table 1
Three, treatment standard control experiment --- canker sore
150 people of canker sore patient is chosen, is randomly divided into 5 groups, wherein (control group is to buy in the market to one group of control group
* reveal clean whitening toothpaste), everyone is each primary daily morning and evening, dosage about 1g lotion/time, after Brushing time 3-5 minutes, 7 days
Detection.
1, grade scale
Cure: pain disappears, all healed in ulcer surface 1-2 days, and mucous membrane of mouth restores normal, and follow-up 3 months without recurrence.
Effective: pain symptom is substantially reduced, and contrafluxion edematous condition disappears, and > 1/2,3-4 is reduced in ulcer surface 1-2 days
Healing, recurrence interval phase are obviously prolonged in it.
Effective: pain symptom is mitigated, and contrafluxion edematous condition is improved, and > 1/ is reduced in ulcer surface 1-2 days
Healing, recurrence interval phase are extended in 3, and≤1/2,5-6 days.
Invalid: the symptoms such as pain, contrafluxion and oedema are without improvement, or even aggravate, and ulcer surface does not heal in 7 days.
2, testing result such as table 2 after 7 days.
Table 2
| Group class | Sum | It cures | It is effective | Effectively | In vain |
| Control group | 30 | 0 | 2 | 3 | 25 |
| Embodiment 1 | 30 | 13 | 6 | 3 | 8 |
| Embodiment 2 | 30 | 13 | 5 | 7 | 5 |
| Embodiment 3 | 30 | 15 | 7 | 5 | 3 |
| Embodiment 4 | 30 | 12 | 8 | 4 | 6 |
As can be seen from Table 2, control group is significantly larger than for the cure rate of canker sore using fat-soluble toothpaste of the invention,
Total effective rate is up to 73-90%.
Four, the experiment for the treatment of standard control --- gingivitis, gingival atrophy, tooth mobility
Gingivitis, gingival atrophy, 100 people of tooth mobility patient are chosen, the age 40-60 years old, 5 groups are randomly divided into, wherein right
According to (control group is that the * bought in the market reveals clean whitening toothpaste) is organized, everyone is each primary daily morning and evening, and dosage about 1g lotion/
It is secondary, it is detected after Brushing time 3-5 minutes, 15 days, as a result such as table 3.
1, grade scale
Cure: pain disappears, and gum is plentiful, and tooth is firm.
Effective: pain is substantially reduced, and gum is obviously plentiful, and tooth is obviously firm.
Effective: pain is mitigated, and gum is plentiful, and tooth is firm.
Invalid: pain, gingival atrophy, tooth mobility symptom is without improvement, or even is aggravated.
2, testing result such as table 3 after 15 days.
Table 3
| Group class | Sum | It cures | It is effective | Effectively | In vain |
| Control group | 20 | 0 | 2 | 3 | 15 |
| Embodiment 1 | 20 | 7 | 5 | 5 | 3 |
| Embodiment 2 | 20 | 8 | 2 | 6 | 4 |
| Embodiment 3 | 20 | 11 | 5 | 2 | 2 |
| Embodiment 4 | 20 | 6 | 6 | 4 | 4 |
Seen from table 3, remote for gingivitis, gingival atrophy, tooth mobility cure rate using fat-soluble toothpaste of the invention
Much higher than control group, total effective rate is up to 80-90%.Wherein there is the formulation efficacy with embodiment 3 best.
The above is multiple preferred embodiments of the invention, but those skilled in the art can want in appended right
Various deformations or amendments are made within the scope of asking, as long as it does not exceed the scope of protection described in the claims to the invention, all
It should be within protection scope of the present invention.
Claims (8)
1. a kind of fat-soluble toothpaste, which is characterized in that by mass percentage, be prepared from the following raw materials: moisturizer 45%-60%,
Rubbing agent 10-20%, purificant 2-3%, adhesive 0.5-1.5%, sweetener 0.1-0.2%, preservative 0.1-0.2%, L-
Ascorbyl palmitate 0.5-1.5%, vitamin E 0.3-0.7%, vitamin B complex 5-10%, zinc gluconate 2-5%, water
Surplus.
2. fat-soluble toothpaste according to claim 1, which is characterized in that by mass percentage, be prepared from the following raw materials: protecting
Humectant 54.8%, rubbing agent 15%, purificant 2.5%, adhesive 1.0%, sweetener 0.15%, preservative 0.15%, L- are anti-
Bad hematic acid palmitate 0.9%, vitamin E 0.5%, vitamin B complex 7%, zinc gluconate 3%, water surplus.
3. fat-soluble toothpaste according to claim 1 or 2, which is characterized in that the moisturizer is sorbierite and/or PEG-
400。
4. fat-soluble toothpaste according to claim 1 or 2, which is characterized in that the rubbing agent is hydrated silica.
5. fat-soluble toothpaste according to claim 1 or 2, which is characterized in that the purificant is lauryl sodium sulfate.
6. fat-soluble toothpaste according to claim 1 or 2, which is characterized in that the adhesive is cellulose gum and xanthan
The combination of glue.
7. fat-soluble toothpaste according to claim 1 or 2, which is characterized in that the sweetener is saccharin sodium.
8. fat-soluble toothpaste according to claim 1 or 2, which is characterized in that the preservative is sodium benzoate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910890685.4A CN110507557A (en) | 2019-09-20 | 2019-09-20 | Fat-soluble toothpaste |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910890685.4A CN110507557A (en) | 2019-09-20 | 2019-09-20 | Fat-soluble toothpaste |
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| CN110507557A true CN110507557A (en) | 2019-11-29 |
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| CN201910890685.4A Pending CN110507557A (en) | 2019-09-20 | 2019-09-20 | Fat-soluble toothpaste |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111632021A (en) * | 2020-07-27 | 2020-09-08 | 浙江爱尚日用品有限公司 | Probiotics toothpaste for preventing gingival atrophy |
| CN112870110A (en) * | 2021-03-22 | 2021-06-01 | 浙江爱尚日用品有限公司 | Halitosis-resisting toothpaste |
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| CN103830145A (en) * | 2014-03-18 | 2014-06-04 | 林彤 | Toothpaste containing biological peptides and traditional Chinese medicines |
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| CN109172482A (en) * | 2018-10-25 | 2019-01-11 | 蒋晗杰 | A kind of toothpaste of anti-treating dental ulcer |
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2019
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| CN101889969A (en) * | 2009-05-20 | 2010-11-24 | 广州薇美姿个人护理用品有限公司 | Natural fluorine-free edible transparent child nutrition toothpaste |
| CN103830145A (en) * | 2014-03-18 | 2014-06-04 | 林彤 | Toothpaste containing biological peptides and traditional Chinese medicines |
| CN104666185A (en) * | 2015-02-13 | 2015-06-03 | 成都润兴消毒药业有限公司 | Liquid toothpaste and preparation method thereof |
| CN105012173A (en) * | 2015-07-09 | 2015-11-04 | 常州艾瑞特电子有限公司 | Toothpaste for preventing and treating oral ulcer and preparation method thereof |
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| CN109172483A (en) * | 2018-10-25 | 2019-01-11 | 蒋晗杰 | A kind of Chinese medicinal toothpaste removed necrosis and promoted granulation |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111632021A (en) * | 2020-07-27 | 2020-09-08 | 浙江爱尚日用品有限公司 | Probiotics toothpaste for preventing gingival atrophy |
| CN112870110A (en) * | 2021-03-22 | 2021-06-01 | 浙江爱尚日用品有限公司 | Halitosis-resisting toothpaste |
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Application publication date: 20191129 |