CN110501458A - A kind of concentration measuring instrument calibration method, device and concentration measuring instrument - Google Patents
A kind of concentration measuring instrument calibration method, device and concentration measuring instrument Download PDFInfo
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Abstract
Embodiment of the present invention discloses a kind of concentration measuring instrument calibration method, device and concentration measuring instrument.This method includes judging whether concentration determination instrument needs to calibrate, however, it is determined that instrument does not need to calibrate, then direct plunges into use；If it is determined that instrument needs to calibrate, then instrument is calibrated, the fitting function between measurement response intensity theory response intensity by obtaining standard sample calibrates the functional relation between measurement response intensity and theoretical response intensity.It is compensated using initial data of the obtained calibration data to measurement, the concentration of the sample to be tested after available instrument calibration, so that it is guaranteed that instrument obtains ideal measurement accuracy in the long-term use.
Description
Technical field
The present invention relates to Calibration of measuring instruments technical field, more particularly to it is a kind of determine concentration measuring instrument calibration method,
Device and concentration measuring instrument.
Background technique
The raising of measurement of concetration level, depends not only upon the quality of operator, is more dependent upon concentration determination instrument itself
Accuracy.During carrying out Concentration Testing using concentration measuring instrument, Concentration Testing instrument is easy by cable distortion, connector
The influence of all kinds of factors such as loosening, the variation of pop one's head in abrasion, machine temperature, electronic component aging, place to use and environment, leads
Measured value is caused biggish error occur.Therefore, it is necessary to be calibrated to instrument, using obtained calibration data to the original of measurement
Data compensate, so that it is guaranteed that instrument can obtain ideal measurement accuracy under different places and environment.
Summary of the invention
In order to overcome the problems, such as measured value that concentration determination instrument occurs in use, there are large error, the present invention
Embodiment mainly solving the technical problems that provide a kind of concentration measuring instrument calibration method, device and concentration measuring instrument,
Initial data in instrument can be corrected, it is ensured that instrument keeps ideal precision in use.
In order to solve the above technical problems, embodiment of the present invention discloses following technical solution is:
In a first aspect, the embodiment of the invention provides a kind of concentration determination instrument calibration methods, which comprises
Obtain the measurement response intensity of standard sample known to actual concentrations；
Judge whether the concentration determination instrument needs to calibrate, if desired calibrates, then:
The concentration of the standard sample is substituted into scaling function, the theoretical response intensity of the standard sample is calculated；
Obtain the fitting between the measurement response intensity of the standard sample and the theoretical response intensity of the standard sample
Function；
Obtain the measurement response intensity of unknown concentration sample to be tested；
The measurement response intensity of the sample to be tested is substituted into the fitting function, calculates the sample to be tested
Theoretical response intensity；
The theoretical response intensity of the sample to be tested is substituted into the scaling function, calculates the sample to be tested
Concentration.
It is optionally, described to judge whether the concentration determination instrument needs to calibrate, comprising:
The measurement response intensity of the standard sample is substituted into the scaling function, calculates the measurement of the standard sample
Concentration；
Calculate the deviation between the actual concentrations of the standard sample and the measurement concentration；
If the deviation is more than preset threshold, determine that the concentration determination instrument needs to calibrate；
If the deviation is less than or equal to the preset threshold, determine that the concentration determination instrument does not need to calibrate.
Optionally, the quantity no more than 3 of the standard sample, it is described when the quantity i of the standard sample is 2
Fitting function is as follows:
Wherein, x is the theoretical response intensity of the sample to be tested, and y is the measurement response intensity of the sample to be tested,
YRec [i] and yfit [i] is respectively the theoretical reaction of the measurement response intensity and the standard sample of i-th of standard sample
Intensity, wherein { 1,2 } i ∈.
Optionally, when the quantity i of the standard sample is 3, the fitting function is as follows:
Wherein, x is the theoretical response intensity of the sample to be tested, and y is the measurement response intensity of the sample to be tested,
YRec [i] and yfit [i] is respectively the theoretical reaction of the measurement response intensity and the standard sample of i-th of standard sample
Intensity, wherein { 1,2,3 } i ∈.
Optionally, the scaling function are as follows:
Wherein, x ' is the actual concentrations of the standard sample or the sample to be tested, and y ' is the standard sample or institute
State the theoretical response intensity of sample to be tested, R0, K, a, b, c be scaling parameter.
Second aspect, the embodiment of the invention provides a kind of concentration tester calibrating installation, described device includes:
First obtains module, the measurement response intensity for standard sample known to actual concentrations；
Judgment module, for judging whether the concentration determination instrument needs to calibrate；
The concentration of the standard sample is then substituted into scaling function for if desired calibrating, calculates institute by calibration module
The theoretical response intensity of standard sample is stated, and, obtain the measurement response intensity and the standard sample of the standard sample
Fitting function between theoretical response intensity；
Second obtains module, for obtaining the measurement response intensity of unknown concentration sample to be tested；
Computing module is calculated for substituting into the measurement response intensity of the sample to be tested in the fitting function
The theoretical response intensity of the sample to be tested, and, described in the theoretical response intensity of the sample to be tested is substituted into
In scaling function, the concentration of sample to be tested is calculated.
Optionally, the judgment module specifically includes:
First computing unit is calculated for substituting into the measurement response intensity of the standard sample in the scaling function
The measurement concentration of the standard sample out；
Second computing unit, it is inclined between the actual concentrations of the standard sample and the measurement concentration for calculating
Difference；
Determination unit determines that the concentration determination instrument needs to calibrate if being more than preset threshold for the deviation, with
And if being less than or equal to the preset threshold for the deviation, determine that the concentration determination instrument does not need to calibrate.
Optionally, the quantity no more than 3 of the standard sample, it is described when the quantity i of the standard sample is 2
Fitting function is as follows:
Wherein, x is the theoretical response intensity of the standard sample, and y is the measurement response intensity of the standard sample, yRec
[i] and yfit [i] are respectively that the theoretical reaction of the measurement response intensity and the standard sample of i-th of standard sample is strong
It spends, wherein { 1,2 } i ∈.
When the quantity i of standard sample is 3, the fitting function is as follows:
Wherein, x is the theoretical response intensity of the sample to be tested, and y is the measurement response intensity of the sample to be tested,
YRec [i] and yfit [i] is respectively the theoretical reaction of the measurement response intensity and the standard sample of i-th of standard sample
Intensity, wherein { 1,2,3 } i ∈.
The third aspect, the embodiment of the invention provides a kind of concentration measuring instruments, comprising:
At least one processor；And
The memory being connect at least one described processor communication；Wherein, the memory be stored with can by it is described extremely
The instruction that a few processor executes, described instruction are executed by least one described processor, so that at least one described processing
Device can be used in executing the concentration determination instrument calibration method.
Fourth aspect, the embodiment of the invention also provides a kind of non-volatile computer readable storage medium storing program for executing, the calculating
Machine readable storage medium storing program for executing is stored with computer executable instructions, and the computer executable instructions are for holding concentration measuring instrument
The row concentration determination instrument calibration method.
The beneficial effect of embodiment of the present invention is: it is in contrast to the prior art, what embodiment of the present invention provided
Concentration determination instrument calibration method, it can be determined that whether concentration determination instrument, which needs, is calibrated, however, it is determined that instrument does not need to calibrate, then
Direct plunge into use；If it is determined that instrument needs to calibrate, then calibrate to instrument: the measurement by obtaining standard sample reacts strong
Fitting function between degree and theoretical response intensity carries out the functional relation between measurement response intensity and theoretical response intensity
Calibration；The measurement response intensity of sample to be tested is obtained again；The measurement response intensity of sample to be tested is substituted into fitting function,
Calculate the theoretical response intensity of sample to be tested；The theoretical response intensity of sample to be tested is substituted into scaling function, is calculated
The concentration of sample to be tested after instrument calibration out.It is compensated using initial data of the obtained calibration data to measurement, from
And ensures instrument and obtain ideal measurement accuracy in the long-term use.
Detailed description of the invention
Fig. 1 is the flow chart of one embodiment of concentration measuring instrument calibration method of the present invention；
Fig. 2 is the straight line fitting figure of the match point of one embodiment of concentration measuring instrument calibration method of the present invention；
Fig. 3 is the structural schematic diagram of one embodiment of concentration measuring instrument calibrating installation of the present invention；
Fig. 4 is the hardware structural diagram of one embodiment of concentration measuring instrument of the present invention.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that described herein, specific examples are only used to explain the present invention, not
For limiting the present invention.
It should be noted that each feature in the embodiment of the present invention can be combined with each other, in this hair if do not conflicted
Within bright protection scope.In addition, though having carried out functional module division in schematic device, shows patrol in flow charts
Sequence is collected, but in some cases, it can be shown in the sequence execution in the module division being different from device or flow chart
The step of out or describing.
Fig. 1 is the flow chart of concentration measuring instrument calibration method of the present invention.The embodiment of the present invention is directed to existing measurement of concetration
Instrument is calibrated, and specific step is as follows for the calibration method:
Step S110 obtains the measurement response intensity of standard sample；
In step s 110, the measurement response intensity of the standard sample of apparatus measures is obtained, wherein the reality of standard sample
Concentration it is known that concentration determination instrument obtain standard sample actual concentrations mode, specifically can be and directly obtained from memory
It takes or is obtained from the data inputted in soft keyboard.Standard sample can select concentration by technical staff according to actual needs
Sample within the specified range, in general, the even concentration for the standard sample selected be distributed in the measurement range of instrument to be calibrated
It is interior.
Step S120, judges whether concentration determination instrument needs to calibrate；
It applies in example some, is judged by the deviation size between the measurement concentration and actual concentrations of calculating standard sample
Whether concentration determination instrument, which needs, is calibrated；Judgment method is as follows:
The measurement response intensity of standard sample is updated in scaling function, the measurement concentration of standard sample is calculated.Often
Scaling function have four parameter Logistic functions, five parameter Logistic functions, cubic spline functions Spline and
Polynomial function etc..
In some embodiments, the scaling function of selection are as follows:
Wherein, x ' is the concentration of standard sample, and y ' is the theoretical response intensity of standard sample, R0, K, a, b, c be calibration
Parameter.
Calculate the measurement concentration c of at least one standard sampleMeasurementWith actual concentrations cIt is practicalBetween deviation | cIt is practical-cMeasurement|, sentence
Whether disconnected instrument, which needs, is calibrated.If there is a sample at least one standard sample | cIt is practical-cMeasurement| it is greater than preset threshold, then really
Determine concentration calibration instrument to need to calibrate, executes step S130.If at least one standard sample, all samples | cIt is practical-cMeasurement|
Both less than or equal to preset threshold, it is determined that concentration determination instrument does not need to calibrate, and can be directly used for concentration determination, executes step
S130’。
It should be noted that preset threshold can be set according to the actual situation by technical staff.For example, if concentration
The measurement of concetration required precision of test equipment is higher, and preset threshold can be set as standard sample actual concentrations by technical staff
0.1%, if the impedance measurement required precision of impedance measuring Instrument is lower, preset threshold can be set as standard sample by technical staff
The 1-5% of product actual concentrations.First preset threshold can also be set as other values, this hair according to actual needs by technical staff
Bright embodiment is not specifically limited in this embodiment.
In order to which reminding technology personnel calibrate concentration determination instrument, in some embodiments, concentration determination instrument is also
It can carry out calibration prompt.It is often necessary to different with the stability of reagent according to detection project method and determining different calibration
Frequency, such as daily calibration, calibration, monthly calibration weekly, or corresponding calibration is determined according to instrument item detection result
Frequency carries out calibration prompt according to preset prover time and/or calibration frequency.For example, if prover time is the 1 of every month
Number, No. 1 concentration determination instrument of every month will carry out calibration prompt.It can be carried out by least one of following manner
Calibration is reminded, for example, closing the currently running program of concentration determination instrument, ear-piercing voice prompt is issued, in concentration tester
The screen of device provides default text prompting message, opens the warning light, etc. of concentration determination instrument.
Step S130 opens calibration mode, calibrates to the concentration determination instrument；
1) calibration point is obtained；
The actual concentrations of at least one standard sample and corresponding measurement response intensity form calibration in obtaining step S130
Point (xRec [i], yRec [i])；Wherein, i indicates the number of calibration point, and i ∈ { 1,2,3 }, xRec [i] indicate i-th of calibration point
Actual concentrations, yRec [i] indicates the response intensity of i-th of calibration point, and assumes all calibration points by increasing concen-trations
Rule is ranked up.
2) the theoretical response intensity of standard sample is obtained by scaling function；
The actual concentrations xRec [i] of calibration point is updated in the scaling function of instrument to be calibrated, i-th of calibration point is obtained
Theoretical response intensity yfit [i].
3) functional relation between standard sample measurement response intensity and theoretical response intensity is obtained.
With the theoretical response intensity yfit [i] of standard sample for abscissa, with the measurement response intensity yRec of standard sample
[i] is ordinate, obtains match point (yfit [i], yRec [i]), includes linear by the method that match point obtains fitting function
Fitting process and the non linear fit method.This is fitted match point for sentencing linear fitting, enables theory response intensity x and survey
Functional relation between quantitative response intensity y is y=kx+b, then:
When the quantity i of calibration point is 1, k=yRec [1]/yfit [1], b=0.The fitting function of acquisition is as follows:
When the quantity i of calibration point is 2,B=yRec [1]-k*yfit [1].What is obtained is quasi-
It is as follows to close function:
It, can be using piecewise linearity differential technique and twice difference method to theoretical response intensity when the quantity i of calibration point is 3
YRec [i] and measurement response intensity yfit [i] carry out straight line fitting.
When using piecewise linearity differential technique,
If 1) [2] y≤yfit,B=yRec [1]-k*yfit [1].The fitting function of acquisition
It is identical as the function in formula (3).
If 2) [2] y > yfit,B=yRec [2]-k*yfit [2].The fitting function of acquisition
It is as follows:
When being fitted using twice difference method, the fitting function of acquisition is as follows:
Step S140 opens measurement pattern, obtains the concentration of unknown concentration sample to be tested.
First obtain the measurement response intensity y of unknown concentration sample to be tested0, further according to the fitting function in step S140
Obtain the theoretical response intensity x of unknown concentration sample to be tested0, by theoretical response intensity x0It is updated in calibration curve equation, i.e.,
The concentration of sample to be tested can be selected.Obtain the theoretical response intensity x of unknown concentration sample to be tested0Method it is as follows:
Still by taking above-mentioned fitting function as an example, when the quantity i of calibration point is 1, by y0It is updated in formula (2), can calculate
The theoretical response intensity of sample to be tested out
When the quantity i of calibration point is 2, by y0It is updated in formula (3), the theoretical reaction of sample to be tested can be calculated
Intensity x0。
When the quantity i of calibration point is 3,
If 1) [2] y≤yfit, by y0It is updated in formula (3), the theoretical response intensity x of sample to be tested can be calculated0；
If 2) [2] y > yfit, by y0It is updated in formula (4), the theoretical response intensity x of sample to be tested can be calculated0。
It in some embodiments, can also be directly by y when the quantity i of calibration point is 30It is updated in formula (5), counts
Calculate the theoretical response intensity x of sample to be tested0。
In order to introduce the calibration method of concentration determination instrument of the present invention in further detail, in the present embodiment, specific number is selected
The calibration point of value is calibrated.Three standard samples are selected in the present embodiment, the calibration point point obtained according to three standard samples
Not are as follows: (100,2000), (170,2750), (280,3700).Assuming that the scaling parameter R in formula (1)0=7, K=
369.31776, a=4.94697, b=0.75772 and c=0.00052, obtained scaling function are as follows:
By the actual concentrations xRec [1]=100, xRec [2]=170, xRec [3] of three calibration point Plays samples=
280 substitute into formula (6) respectively, calculate the theoretical response intensity of standard sample, and yfit [1]=1851.6, yfit [2]=
2586.6, [3]=3472.1 yfit, the theoretical response intensity and measurement response intensity of standard sample constitute three match points
(1851.6,2000), (2586.6,2750), (3472.1,3700).By match point obtain fitting function method include but
It is not limited to twice difference method and piecewise linearity differential technique.Referring to Fig. 2, the present embodiment uses piecewise linearity differential technique, to three
Match point carries out straight line fitting, and the fitting function between obtained theoretical response intensity x and measurement response intensity y is as follows:
When y≤yfit [2],
B=yRec [1]-k × yfit [the 1]=≈ of 2000-1.0204 × 1851.6 110.6274
The fitting function of acquisition is as follows:
Y=kx+b=1.0204*x+110.6274 (7)
When [2] y > yfit,
B=yRec [2]-k*yfit [2]=2750-1.0728*2586.6 ≈ -24.9045
The fitting function of acquisition is as follows:
Y=kx+b=1.0728*x-24.9045 (8)
After acquiring intensity calibration transformation relation, theoretical response intensity can be obtained by apparatus measures response intensity.Assuming that
It is 3000 that the sample to be tested of unknown concentration measures response intensity size on instrument.Since second calibration point response intensity is
2750, and 3000 > 2750, therefore, will measure response intensity is updated in formula (8), and the theory for calculating sample to be tested is anti-
Intensity is answered, calculating process is as follows:
X=(y-24.9045)/1.0728=(3000+24.9045)/1.0728=2819.6
Theoretical response intensity 2819.6 is substituted into the scaling function in formula (6), the dense of sample to be tested can be calculated
Degree is 196.03.
Fig. 3 is a kind of structural schematic diagram of concentration determination calibrating installation provided in an embodiment of the present invention.As shown in figure 3, should
Device 40 includes: the first acquisition module 41, judgment module 42, the acquisition module 44 of calibration module 43, second and computing module 45.
Wherein, first module 41, the measurement response intensity of the standard sample for obtaining apparatus measures are obtained；Its Plays
The actual concentrations of sample it is known that the standard sample actual concentrations that concentration determination instrument obtains mode, specifically can be from storage
It directly acquires in device or is obtained from the data inputted in soft keyboard.Judgment module 42, for judging that concentration determination instrument is
It is no to need to calibrate；The concentration of standard sample is then substituted into scaling function, is calculated for if desired calibrating by calibration module 43
The theoretical response intensity of standard sample.Calibration module 43 is also used to obtain standard sample measurement response intensity and standard sample reason
By the fitting function between response intensity.Second obtains module 44, and the measurement for obtaining unknown concentration sample to be tested is reacted
Intensity；Computing module 45 calculates described for the measurement response intensity of the sample to be tested to be substituted into the fitting function
The theoretical response intensity of sample to be tested, and, for the theoretical response intensity of the sample to be tested to be substituted into scaling function,
Calculate the concentration of sample to be tested.
In some embodiments, judgment module 42 includes the first computing unit 421, the second computing unit 422 and determines single
Member 423.Wherein, the first computing unit 421 calculates bid for the measurement response intensity of standard sample to be substituted into scaling function
The measurement concentration of quasi- sample；Second computing unit 422, the reason of measurement response intensity and standard sample for calculating standard sample
By the deviation between response intensity；Determination unit 423 determines concentration determination instrument needs if being more than preset threshold for deviation
Calibration, and if deviation be not more than preset threshold, determine that concentration determination instrument does not need to calibrate.
In some embodiments, concentration determination instrument calibrating installation further includes calibration reminding module (not shown).Calibration mentions
Awake module can be used for carrying out calibration prompting according to preset prover time and/or calibration frequency.Calibrating reminding module includes record
Unit and acquiring unit.Recording unit is used to record the specific time of calibration instrument each time.Acquiring unit is next for obtaining
The secondary time for carrying out calibration prompting.It is calibrated if being issued when reminding unit matches for current time and default prover time
It reminds.
Since Installation practice and embodiment of the method under the premise of content does not conflict mutually, are filled based on same design
The content for setting embodiment can be with the content of quoting method embodiment, and this will not be repeated here.
It should be noted that modules, unit in concentration determination instrument calibrating installation provided in an embodiment of the present invention
Between the contents such as information exchange, implementation procedure, due to being based on same design with embodiment of the present invention method, particular content is same
Suitable for concentration determination instrument calibrating installation.Modules in the embodiment of the present invention can be used as individual software realize, and
And the combination for realizing the function of each unit is can according to need using individual software.
Referring to Fig. 4, concentration determination instrument 100 provided in an embodiment of the present invention include one or more processors 1 and
Memory 2, in Fig. 4 by taking a processor 1 as an example.Processor 1 can be connected with memory 2 by bus or other modes,
In Fig. 4 for being connected by bus.
Memory 2 be used as a kind of non-volatile computer readable storage medium storing program for executing, can be used for storing non-volatile software program,
Non-volatile computer executable program and module, as the concentration determination instrument calibration method in the embodiment of the present application is corresponding
Program instruction/module is (for example, attached shown in Fig. 3 first obtains module 41, judgment module 42, the acquisition mould of calibration module 43, second
Block 44 and computing module 45).Non-volatile software program, instruction and the mould that processor 1 is stored in memory 2 by operation
Block realizes the concentration determination of above method embodiment thereby executing the various function application and data processing of electronic equipment
Instrument detection method.
Memory 2 may include storing program area and storage data area, wherein storing program area can storage program area,
Application program required at least one function；Storage data area, which can be stored, uses created data etc. according to controller.
It can also include nonvolatile memory in addition, memory 2 may include high-speed random access memory, for example, at least one
Disk memory, flush memory device or other non-volatile solid state memory parts.In some embodiments, memory 2 is optional
Including the memory remotely located relative to processor 1, these remote memories can pass through network connection to electronic equipment.On
The example for stating network includes but is not limited to internet, intranet, local area network, mobile radio communication and combinations thereof.
One or more of modules are stored in the memory 2, are held when by one or more of processors 1
When row, the concentration determination instrument calibration method in above-mentioned any means embodiment is executed, for example, executing in Fig. 1 described above
Method and step 110-140；Realize the module 41-42 in Fig. 3.
Method provided by the embodiment of the present application can be performed in the said goods, has the corresponding functional module of execution method and has
Beneficial effect.The not technical detail of detailed description in the present embodiment, reference can be made to method provided by the embodiment of the present application.
The embodiment of the present application provides a kind of non-volatile computer readable storage medium storing program for executing, the computer-readable storage medium
Matter is stored with computer executable instructions, which is executed by one or more processors, such as in Fig. 4
One processor 1 may make said one or multiple processors that the concentration measuring apparatus in above-mentioned any means embodiment can be performed
Device calibration method, for example, executing the method and step 110-140 in Fig. 1 described above；Realize the module 41-42 in Fig. 3.
The apparatus embodiments described above are merely exemplary, wherein described, unit can as illustrated by the separation member
It is physically separated with being or may not be, component shown as a unit may or may not be physics list
Member, it can it is in one place, or may be distributed over multiple network units.It can be selected according to the actual needs
In some or all of the modules achieve the purpose of the solution of this embodiment.
By the description of above embodiment, those of ordinary skill in the art can be understood that each embodiment can borrow
Help software that the mode of general hardware platform is added to realize, naturally it is also possible to pass through hardware.Those of ordinary skill in the art can manage
Solution realize above-described embodiment method in all or part of the process be can be instructed by computer program relevant hardware come
It completes, the program can be stored in a computer-readable storage medium, and the program is when being executed, it may include such as above-mentioned each
The process of the embodiment of method.Wherein, the storage medium can be magnetic disk, CD, read-only memory (Read-Only
Memory, ROM) or random access memory (Random Access Memory, RAM) etc..
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；At this
It under the thinking of invention, can also be combined between the technical characteristic in above embodiments or different embodiment, step can be with
It is realized with random order, and there are many other variations of different aspect present invention as described above, for simplicity, they do not have
Have and is provided in details；Although the present invention is described in detail referring to the foregoing embodiments, the ordinary skill people of this field
Member is it is understood that it is still possible to modify the technical solutions described in the foregoing embodiments, or to part of skill
Art feature is equivalently replaced；And these are modified or replaceed, each reality of the present invention that it does not separate the essence of the corresponding technical solution
Apply the range of a technical solution.
Claims (10)
1. a kind of concentration determination instrument calibration method, which is characterized in that the described method includes:
Obtain the measurement response intensity of standard sample known to actual concentrations；
Judge whether the concentration determination instrument needs to calibrate, if desired calibrates, then:
The concentration of the standard sample is substituted into scaling function, the theoretical response intensity of the standard sample is calculated；
Obtain the fitting function between the measurement response intensity of the standard sample and the theoretical response intensity of the standard sample；
Obtain the measurement response intensity of unknown concentration sample to be tested；
The measurement response intensity of the sample to be tested is substituted into the fitting function, calculates the theory of the sample to be tested
Response intensity；
The theoretical response intensity of the sample to be tested is substituted into the scaling function, calculates the dense of the sample to be tested
Degree.
2. concentration determination instrument calibration method according to claim 1, which is characterized in that the judgement concentration determination
Whether instrument, which needs, is calibrated, comprising:
The measurement response intensity of the standard sample is substituted into the scaling function, the measurement for calculating the standard sample is dense
Degree；
Calculate the deviation between the actual concentrations of the standard sample and the measurement concentration；
If the deviation is more than preset threshold, determine that the concentration determination instrument needs to calibrate；
If the deviation is less than or equal to the preset threshold, determine that the concentration determination instrument does not need to calibrate.
3. calibration curve calibration method according to claim 1 or 2, which is characterized in that the quantity of the standard sample is not
More than 3, when the quantity i of the standard sample is 2, the fitting function is as follows:
Wherein, x is the theoretical response intensity of the sample to be tested, and y is the measurement response intensity of the sample to be tested, yRec
[i] and yfit [i] are respectively that the theoretical reaction of the measurement response intensity and the standard sample of i-th of standard sample is strong
Degree, wherein i ∈ { 1,2 }.
4. calibration curve calibration method according to claim 1 or 2, which is characterized in that as the quantity i of the standard sample
When being 3, the fitting function is as follows:
Wherein, x is the theoretical response intensity of the sample to be tested, and y is the measurement response intensity of the sample to be tested, yRec
[i] and yfit [i] are respectively that the theoretical reaction of the measurement response intensity and the standard sample of i-th of standard sample is strong
It spends, wherein { 1,2,3 } i ∈.
5. concentration determination instrument calibration method according to claim 2, which is characterized in that the scaling function are as follows:
Wherein, x ' is the actual concentrations of the standard sample or the sample to be tested, y ' be the standard sample or it is described to
The theoretical response intensity of test sample, R0, K, a, b, c be scaling parameter.
6. a kind of concentration tester calibrating installation, which is characterized in that described device includes:
First obtains module, the measurement response intensity for standard sample known to actual concentrations；
Judgment module, for judging whether the concentration determination instrument needs to calibrate；
The concentration of the standard sample is then substituted into scaling function for if desired calibrating, calculates the mark by calibration module
The theoretical response intensity of quasi- sample, and, obtain the theory of the measurement response intensity and the standard sample of the standard sample
Fitting function between response intensity；
Second obtains module, for obtaining the measurement response intensity of unknown concentration sample to be tested；
Computing module calculates described for substituting into the measurement response intensity of the sample to be tested in the fitting function
The theoretical response intensity of sample to be tested, and, for the theoretical response intensity of the sample to be tested to be substituted into the calibration
In function, the concentration of sample to be tested is calculated.
7. concentration tester calibrating installation according to claim 6, which is characterized in that the judgment module specifically includes:
First computing unit calculates institute for substituting into the measurement response intensity of the standard sample in the scaling function
State the measurement concentration of standard sample；
Second computing unit, for calculating the deviation between the actual concentrations of the standard sample and the measurement concentration；
Determination unit determines that the concentration determination instrument needs to calibrate if being more than preset threshold for the deviation, and, it uses
If being less than or equal to the preset threshold in the deviation, determine that the concentration determination instrument does not need to calibrate.
8. device according to claim 6 or 7, which is characterized in that the quantity no more than 3 of the standard sample；
When the quantity i of the standard sample is 2, the fitting function is as follows:
Wherein, x is the theoretical response intensity of the sample to be tested, and y is the measurement response intensity of the sample to be tested, yRec
[i] and yfit [i] are respectively that the theoretical reaction of the measurement response intensity and the standard sample of i-th of standard sample is strong
It spends, wherein { 1,2 } i ∈；
When the quantity i of the standard sample is 3, the fitting function is as follows:
Wherein, x is the theoretical response intensity of the sample to be tested, and y is the measurement response intensity of the sample to be tested, yRec
[i] and yfit [i] are respectively that the theoretical reaction of the measurement response intensity and the standard sample of i-th of standard sample is strong
It spends, wherein { 1,2,3 } i ∈.
9. a kind of concentration measuring instrument, which is characterized in that the measuring instrument includes:
At least one processor；And
The memory being connect at least one described processor communication；Wherein, be stored with can be by described at least one for the memory
The instruction that a processor executes, described instruction is executed by least one described processor, so that at least one described processor energy
It is enough in perform claim and requires 1 to 5 described in any item concentration determination instrument calibration methods.
10. a kind of non-volatile computer readable storage medium storing program for executing, which is characterized in that the computer-readable recording medium storage has
Computer executable instructions, the computer executable instructions are for executing concentration measuring instrument as claim 1-5 is any
Concentration determination instrument calibration method described in.
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| PCT/CN2019/125706 WO2021017374A1 (en) | 2019-07-29 | 2019-12-16 | Concentration measuring instrument calibration method and apparatus, and concentration measuring instrument |
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| WO2021017374A1 (en) * | 2019-07-29 | 2021-02-04 | 深圳市锦瑞生物科技有限公司 | Concentration measuring instrument calibration method and apparatus, and concentration measuring instrument |
| CN113834986A (en) * | 2021-09-02 | 2021-12-24 | 上汽通用五菱汽车股份有限公司 | Method for measuring electric signal error proofing, measuring equipment and readable storage medium |
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