CN110496305A - A kind of preparation method of floating travelling micro-machine - Google Patents
A kind of preparation method of floating travelling micro-machine Download PDFInfo
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- CN110496305A CN110496305A CN201910786262.8A CN201910786262A CN110496305A CN 110496305 A CN110496305 A CN 110496305A CN 201910786262 A CN201910786262 A CN 201910786262A CN 110496305 A CN110496305 A CN 110496305A
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- micro
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/10—Metallic powder containing lubricating or binding agents; Metallic powder containing organic material
- B22F1/102—Metallic powder coated with organic material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/17—Metallic particles coated with metal
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
- C23C14/06—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
- C23C14/14—Metallic material, boron or silicon
- C23C14/16—Metallic material, boron or silicon on metallic substrates or on substrates of boron or silicon
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
- C23C14/22—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
- C23C14/24—Vacuum evaporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
Abstract
The present invention provides a kind of preparation method of floating travelling micro-machine, belongs to the preparation from driving micro-machine and drive the applied technical field of micro-machine certainly.A kind of preparation method of floating travelling micro-machine of the present invention includes: one, metal pretreated ball；Two, gold is plated to metal ball surface with electron beam evaporation methods；Three, polyester terephthalate is sprayed in metal ball；Four, metal ball is lived with gelatin coatings；Five, metal ball outermost layer modifies paraffin；A kind of application of the preparation method of floating travelling micro-machine of the present invention are as follows: into the water by this floating travelling micro-machine, can realize that driving movement, the moving condition certainly of its own are readily satisfied by bubble driving, preparation is simple, experimental repeatability height.The floating travelling micro-machine of preparation of the invention has wide practical use in field of biomedicine.
Description
Technical field
The present invention relates to it is a kind of floating travelling micro-machine preparation method and application, belong to from driving micro-machine preparation and
From the applied technical field of driving micro-machine.
Background technique
It is the hot fields of nano science in recent years using the travelling micro-machine that different materials manufacture, making material determines
Its different motion mode and mechanism.It is existing travelling micro-machine drive mechanism can be divided into bubble driving, from electrophoresis with
And diffusiophoresis etc..Used in being driven in travelling micro-machine bubble in fuel, use hydrogen peroxide as fuel the most
Extensively.But hydrogen peroxide, as fuel, poor biocompatibility has certain toxicity, is not used in organism, therefore
It is badly in need of replacement fuel of a kind of pair of organism with hypotoxicity and good biocompatibility for potential biomedical and environment prison
Control application.
Summary of the invention
The purpose of the present invention is to solve the above-mentioned problems of the prior art, i.e. the travelling micro-machine of bubble driving,
Its chemical fuel biocompatibility is bad, and moving condition is harsh, and preparation is complicated, it is difficult to be applied in organism, and when movement
Between short, the problems such as subsequent motion driving force is insufficient, and then provide a kind of preparation method and applications of floating travelling micro-machine.
The purpose of the present invention is what is be achieved through the following technical solutions:
A kind of preparation method of floating travelling micro-machine, a kind of preparation method specific steps of floating travelling micro-machine
Are as follows:
Step 1: acetone, isopropanol and ethyl alcohol is successively used respectively to clean three 0.5-2000 μm of average-size of metal ball
It is secondary；
Step 2: the metal ball cleaned up is distributed in water, is then that 0.1-2000mg/ml contains metal by concentration
The solution drop of ball is then that the inclined-plane 0.1o to 78o dries in tilt angle on the glass sheet；
Step 3: the gold vapor deposition with a thickness of 0.1-200nm is arrived to the glass sheet surface of step 2 with electron beam evaporation methods；
Step 4: polyester terephthalate is sprayed to the glass sheet surface of step 3；
Step 5: metal ball is separated from glass sheet surface by ultrasonic wave or mechanical means, it is molten to be then added to gelatin
In liquid, gelatin solution is slowly heated to 30-150 DEG C；
Step 6: the solution in step 5 is injected into temperature with the speed of 0.01-200ml/s and is 60-200 DEG C, rotates
Flow velocity is to continue 0.5-24 hours in the atoleine solution of 10-2000mg/s, be then cooled to room temperature solution；
Step 7: using revolving speed to separate particle with solution for the centrifuge of 100-20000rpm, and successively uses tetrahydro
Furans, acetone and water respectively clean obtains sample three times.
The present invention it is a kind of floating travelling micro-machine preparation method, the metal ball using gold goal, ping-pong ball, copper ball, iron ball,
Magnesium ball or aluminium ball.
A kind of preparation method of floating travelling micro-machine of the present invention, in step 1, metal ball be gold goal, ping-pong ball, copper ball or
When iron ball, the metallics of electron beam evaporation plating is magnesium in step 3.
A kind of preparation method of floating travelling micro-machine of the present invention, in the step 5, gelatin solution can change poly- second into
Alkene pyrrolidone, polyvinyl alcohol, polylactic acid, agar, bovine serum albumin or chitosan solution.
A kind of preparation method of floating travelling micro-machine of the present invention, in the experiment, all experimental waters are deionization
Water.
A kind of application of the preparation method of floating travelling micro-machine, into the water by floating travelling micro-machine, regulation
The direction of motion and rate of travelling micro-machine in water are floated, the motion mode in water is bubble driving.
A kind of preparation method of floating travelling micro-machine of the present invention, has process simple, size is controllable and uniform, at the later period
The advantages that reason is few, and the resting period is long, has both quantity；Because its fuel is water, with unique non-toxic and good biocompatibility
Feature may serve to carry medicine in all organisms, achieve the purpose that travelling micro-machine is applied in biomedicine.The present invention
The floating travelling micro-machine of preparation has wide practical use in fields such as biomedicine, environmental monitorings.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of floating travelling micro-machine of the invention.
Fig. 2 is the motion principle figure of floating travelling micro-machine of the invention.
Fig. 3 is the time series photo of the photoacoustic imaging movement of the floating travelling micro-machine of test example preparation.
Fig. 4 is the stereoscan photograph of the floating travelling micro-machine of test example preparation.
Fig. 5 is the optical microscope photograph in the floating travelling micro-machine motion process of test example preparation.
Appended drawing reference in figure: 1 is magnesium ball；2 be gold；3 be polyester terephthalate；4 be gelatin；5 be paraffin.
Specific embodiment
Below in conjunction with attached drawing, the present invention is described in further detail: the present embodiment is being with technical solution of the present invention
Under the premise of implemented, give detailed embodiment, but protection scope of the present invention is not limited to following embodiments.
Embodiment one: as shown in Figs. 1-5, a kind of preparation method of floating travelling micro-machine involved in the present embodiment should
The optimal case of method:
Step 1: 10 μm of average-size of magnesium ball is successively used into acetone, isopropanol and ethyl alcohol respectively clean three times.
Step 2: the magnesium ball after cleaning up is distributed in water, by concentration is that 2mg/ml contains metal ball with liquid-transfering gun
Solution drop on the glass sheet, then tilt angle be 45 degree of inclined-planes dry.
Step 3: glass sheet surface will be arrived with a thickness of the gold modification of 10nm with electron beam evaporation methods.
Step 4: polyester terephthalate is sprayed into glass sheet surface.
Step 5: metal ball is separated from glass sheet surface by ultrasonic wave or mechanical means, gelatin solution is then added
In, slow heating solution reaches 60 DEG C.
Step 6: the above-mentioned solution for being heated to 60 DEG C is injected into temperature with the speed of 2ml/s as 60 DEG C, rotation flow velocity is
In the atoleine solution of 200ml/s, continues 6 hours, be then cooled to room temperature solution.
Step 7: using revolving speed to separate particle for the centrifugal method of 1000rpm, and successively each using tetrahydrofuran and water
Cleaning obtains floating travelling micro-machine three times.
In step 1, when metal ball uses gold goal, ping-pong ball, copper ball, iron ball, the metallics of electron beam evaporation plating in step 3
For magnesium.
In step 5, gelatin solution can also change polyvinylpyrrolidone, polyvinyl alcohol, polylactic acid, agar, cow's serum into
Albumen or chitosan solution.
In experiment, all experimental waters are deionized water.
As shown in Figure 1, the present invention using 20 μm of average-size of magnesium ball as basic material, is successively modified in its outer surface
Gold, polyester terephthalate, gelatin, paraffin.Floating travelling micro-machine is obtained, will be added in floating travelling micro-machine merging water
Sodium chloride and surfactant, the asymmetry that travelling micro-machine is modified by it, are reacted with water, generate hydrogen, are realized
Effective exercise in water.The present invention has process simple, and size is controllable and uniform, and post-processing is few, and the resting period is long, has both
The advantages that quantity.Because its fuel is water, has the characteristics that unique non-toxic and good biocompatibility, in all organisms all
It can be used to carry medicine, achieve the purpose that travelling micro-machine is applied in biomedicine.
Embodiment two: as shown in Fig. 2, a kind of preparation method of floating travelling micro-machine involved in the present embodiment is answered
With arrow direction is to float robot motion direction in Fig. 2, into the water by the floating travelling micro-machine of preparation, can be adjusted
Control floats the direction of motion and rate of travelling micro-machine in water, and the motion mode in water is bubble driving application.
Embodiment three: as in Figure 3-5, involved in the present embodiment it is a kind of floating travelling micro-machine preparation method and answer
With the time series photo of the photoacoustic imaging movement for the floating travelling micro-machine that this test example obtains is as shown in figure 3, can from Fig. 3
To find out, this floating travelling micro-machine can carry out the movement of bubble driving from bottom to top in water.
The stereoscan photograph for the floating travelling micro-machine that this test example obtains micro-machine as shown in figure 4, floating is moved about
Diameter is 10-20 μm, and the surface modification of floating travelling micro-machine has the characteristics that mal-distribution.
The floating travelling micro-machine that this test example obtains is placed in salting liquid and adjusts pH value, realizes travelling machine movement.
The foregoing is only a preferred embodiment of the present invention, these specific embodiments are all based on the present invention
Different implementations under general idea, and scope of protection of the present invention is not limited thereto, it is any to be familiar with the art
Technical staff in the technical scope disclosed by the present invention, any changes or substitutions that can be easily thought of, should all cover of the invention
Within protection scope.Therefore, the scope of protection of the invention shall be subject to the scope of protection specified in the patent claim.
Claims (6)
1. a kind of preparation method of floating travelling micro-machine, which is characterized in that a kind of preparation side of floating travelling micro-machine
Method specific steps are as follows:
Step 1: acetone, isopropanol and ethyl alcohol is successively used respectively to clean three times 0.5-2000 μm of average-size of metal ball；
Step 2: the metal ball cleaned up is distributed in water, is then that 0.1-2000mg/ml contains metal ball by concentration
Solution drips on the glass sheet, is then that 0.1 ° to 78 ° inclined-plane dries in tilt angle；
Step 3: the gold vapor deposition with a thickness of 0.1-200nm is arrived to the glass sheet surface of step 2 with electron beam evaporation methods；
Step 4: polyester terephthalate is sprayed to the glass sheet surface of step 3；
Step 5: being separated from glass sheet surface by metal ball by ultrasonic wave or mechanical means, be then added in gelatin solution,
Solution is slowly heated to 30-150 DEG C；
Step 6: the solution in step 5 is injected into temperature with the speed of 0.01-200ml/s and is 60-200 DEG C, rotates flow velocity
To continue 0.5-24 hours, being then cooled to room temperature solution in the atoleine solution of 10-2000mg/s；
Step 7: using revolving speed to separate particle with solution for the centrifuge of 100-20000rpm, and successively using tetrahydrofuran,
Acetone and water respectively clean obtains sample three times.
2. a kind of preparation method of floating travelling micro-machine according to claim 1, which is characterized in that the metal ball is
Gold goal, ping-pong ball, copper ball, iron ball or magnesium ball.
3. a kind of preparation method of floating travelling micro-machine according to claim 1 or 2, which is characterized in that in step 1,
When metal ball is gold goal, ping-pong ball, copper ball or iron ball, the metallics of electron beam evaporation plating is magnesium in step 3.
4. a kind of preparation method of floating travelling micro-machine according to claim 1, which is characterized in that in the step 5
Gelatin solution can change polyvinylpyrrolidone, polyvinyl alcohol, polylactic acid, agar, bovine serum albumin or chitosan solution into.
5. a kind of preparation method of floating travelling micro-machine according to claim 1, which is characterized in that in the experiment,
All experimental waters are deionized water.
6. a kind of a kind of application of the preparation method of floating travelling micro-machine described in claim 1, which is characterized in that will be described
Into the water, regulation floats the direction of motion and rate of travelling micro-machine in water, the movement side in water to floating travelling micro-machine
Formula is bubble driving.
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| CN201910786262.8A CN110496305A (en) | 2019-08-24 | 2019-08-24 | A kind of preparation method of floating travelling micro-machine |
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| CN201910786262.8A CN110496305A (en) | 2019-08-24 | 2019-08-24 | A kind of preparation method of floating travelling micro-machine |
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| JP2004350803A (en) * | 2003-05-28 | 2004-12-16 | Hasegawa Tokuichiro | Eye mask and visual acuity correcting jig |
| CN102556935A (en) * | 2012-03-06 | 2012-07-11 | 哈尔滨工业大学 | Artificial hollow micro-nano motor and preparation method thereof |
| CN105309477A (en) * | 2015-10-22 | 2016-02-10 | 苏州大学 | Self-propelling bacterium-killing micrometer motor |
| CN107312116A (en) * | 2017-05-23 | 2017-11-03 | 程志峰 | A kind of preparation method of macromolecule Janus microsphere particles |
| CN107383282A (en) * | 2016-05-16 | 2017-11-24 | 中国科学院理化技术研究所 | A kind of synthetic method with chemistry and the anisotropic polymer Janus particles of topology |
| CN108524941A (en) * | 2018-04-08 | 2018-09-14 | 哈尔滨工业大学 | A kind of enzyme driving ampuliform nano-motor and preparation method thereof |
-
2019
- 2019-08-24 CN CN201910786262.8A patent/CN110496305A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004350803A (en) * | 2003-05-28 | 2004-12-16 | Hasegawa Tokuichiro | Eye mask and visual acuity correcting jig |
| CN102556935A (en) * | 2012-03-06 | 2012-07-11 | 哈尔滨工业大学 | Artificial hollow micro-nano motor and preparation method thereof |
| CN105309477A (en) * | 2015-10-22 | 2016-02-10 | 苏州大学 | Self-propelling bacterium-killing micrometer motor |
| CN107383282A (en) * | 2016-05-16 | 2017-11-24 | 中国科学院理化技术研究所 | A kind of synthetic method with chemistry and the anisotropic polymer Janus particles of topology |
| CN107312116A (en) * | 2017-05-23 | 2017-11-03 | 程志峰 | A kind of preparation method of macromolecule Janus microsphere particles |
| CN108524941A (en) * | 2018-04-08 | 2018-09-14 | 哈尔滨工业大学 | A kind of enzyme driving ampuliform nano-motor and preparation method thereof |
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Application publication date: 20191126 |