CN110487754B - Method for realizing simultaneous sensing of dual parameters containing chiral parameters based on optical fiber sensor - Google Patents
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Abstract
The invention discloses a method for realizing simultaneous sensing of dual parameters containing chiral parameters based on an optical fiber sensor, and belongs to the technical field of optical fiber sensing. The invention derives the wave equation of the chiral medium from the constitutive relation of the chiral medium, designs and realizes the optical fiber sensor with higher sensitivity by using a numerical calculation method, and realizes the double-parameter sensing of the chiral parameters and other parameters of the medicine by combining the test results of the cascade or two optical fiber sensors with different sensitivities with a graphical method. The method can solve the problem of high-sensitivity sensing of the dual parameters of the chiral parameters and other parameters at the same time, and realizes the detection of the chiral parameters in a large dynamic range. The method can be popularized to any type of optical fiber sensor for dual-parameter measurement and sensor design containing chiral parameters, and can also be popularized to the sensing characteristic research under other chiral medium models.
Description
Technical Field
The invention belongs to the technical field of optical fiber sensing, and particularly relates to a method for simultaneously sensing chiral parameters of chiral drugs and double parameters of refractive index, temperature or concentration with high sensitivity.
Background
The optical fiber sensor technology is a technical field which is rapidly researched and developed in recent years. Up to now, the optical fiber sensor has been mature for sensing and detecting parameters such as refractive index, temperature, concentration, acceleration, pressure, etc. And because the optical fiber sensor has the advantages of low cost, small volume, difficult electromagnetic interference and the like, the optical fiber sensor is widely applied to various fields of life science, industry, medicine, aerospace and the like. Among them, various optical fiber sensors based on Surface Plasmon Resonance (SPR) have been popular with researchers in the fields of bio-detection science, medical research, and the like because of their advantages of high sensitivity, capability of performing nondestructive detection in real time, no need of labeling, and the like. The optical fiber sensors are divided according to the types of optical fibers, and the optical fiber sensors based on the SPR principle mainly comprise the following components: common optical fiber sensors, photonic crystal optical fiber sensors, fiber grating sensors, etc. The sensitivity and the dynamic range are used as important indexes of the sensor, and the performance of the sensor is reflected. The sensing characteristics of sensors of different structures are often different for the detection of the same parameter. The higher the sensitivity and the larger the dynamic range of the sensor, the stronger the detection capability of the parameter to be detected.
The chiral parameter is one of a plurality of medium parameters in the constitutive relation of chiral media in the field of electromagnetism. The parameter has a certain relation with the optical rotation in the optical field and the drug property of chiral drugs in biomedicine. Chiral drugs contain two enantiomers that are mirror images of each other and do not coincide, usually one molecule has a high pharmaceutical value, while the other molecule may be useless or even sometimes counterproductive to the effect. The detection of chiral parameters of a chiral drug is helpful to distinguish the specific gravity of two enantiomers with different medicinal values. Enantiomers have optical activity, and when two enantiomers form a mixture in different proportions, the optical activity of the drug mixture changes. The chiral parameters of the chiral drugs are detected by using a label-free optical fiber sensing technology, and then the specific gravities of the two enantiomers are detected, so that the method has important significance for the development of the fields of biomedicine, pharmacology, environmental science and the like.
The chiral parameters and the refractive index have similar variation trends under the same resonance peak, and both have nonlinear trends along with the variation of the parameters such as wavelength, frequency and the like. Since the refractive index changes due to the change of temperature, concentration, etc., the optical fiber sensor is also often used for sensing the above parameters. In patent document 108106752A entitled "dual-parameter sensor device for temperature and strain of optical fiber F-P based on Sagnac loop", a device for sensing dual parameters of temperature and strain of optical fiber F-P based on Sagnac loop is disclosed, which utilizes the reaction characteristics of optical fiber F-P structure and polarization-maintaining Sagnac loop to temperature and strain to realize simultaneous sensing of dual parameters of temperature and strain. In patent document 108254018A entitled "method for manufacturing stress and temperature dual-parameter sensor based on LPFG cascaded FBG", a method for achieving simultaneous sensing of dual parameters by using a dual-parameter matrix method in combination with a long-period fiber grating and bragg fiber grating cascade is disclosed. None of the above patents are concerned with sensing chiral parameters.
Dual-parameter simultaneous sensing is a popular direction of research in the field of optical fiber sensing. So far, commonly used dual-parameter sensing methods are a dual-wavelength matrix method, a dual-parameter matrix method, and inversion in combination with a genetic algorithm. Two matrix methods are often applied to a grating having a resonant wavelength with two loss peaks as its sensor device, and the application condition is that two intrinsic parameters of the sensor vary linearly with two parameters to be measured. Since the chiral parameters and the refractive index mostly have nonlinear variation trends along with the variation of wavelength and frequency, the two matrix methods are not suitable for the detection of the chiral parameters.
Patent document 109163745a entitled "a method for detecting multiple parameters based on SPR principle" discloses that a common D-type optical fiber sensor is used to invert measured data by combining an analytic propagation matrix method and a genetic algorithm, so that a chiral parameter and a refractive index can be simultaneously sensed. However, the method has the defects of low sensitivity, insufficient dynamic range and the like. For optical fibers with more complex structures, such as photonic crystal sensors and photonic crystal grating sensors based on the SPR principle, the method cannot obtain results by using an analytic method, and the sensitivity of the more complex optical fiber structure is higher under the general condition.
The invention combines a numerical calculation method and a graphical method and designs the optical fiber sensor with a complex structure, thereby realizing the double-parameter detection containing chiral parameters with nonlinear change, high sensitivity and large dynamic range.
Disclosure of Invention
The invention aims to provide a method for realizing double-parameter sensing of chiral parameters and other parameters aiming at the defects and blanks in the background technology. The method combines a numerical calculation method and a graphical method, and realizes the high-sensitivity simultaneous sensing of both parameters of the feature parameter and other parameters by adopting a cascade connection mode or two high-sensitivity optical fiber sensors. The sensor has the advantages of wide application range, high sensing sensitivity, large dynamic range and the like. Has important significance for the application fields of optical fiber sensing, medicine, bioscience and the like.
A method for realizing simultaneous sensing of dual parameters containing chiral parameters based on an optical fiber sensor is characterized by comprising the following steps:
s1: two types of fiber optic sensors of model A, B with different sensitivities were selected.
S2: by combining a wave equation under a chiral medium model with a finite element and other numerical calculation methods, the resonant wavelength of a loss peak containing chiral parameters of the A-type and B-type high-sensitivity optical fiber sensors under different refractive indexes, temperatures or concentrations when the chiral parameters are changed is calculated in a simulation manner. And respectively drawing three-dimensional curved surface graphs P and Q corresponding to the A, B type optical fiber sensors by using the resonance wavelength of the loss peak as z-axis data, the chiral parameter as x-axis data and the refractive index, temperature or concentration as y-axis data through an interpolation method.
S3: respectively preparing A, B type two optical fiber sensors or a cascade A, B type two optical fiber sensors;
s4: preparing the solution to be detected with different proportions of enantiomer contents. Building a test platform, respectively testing in A, B type two sensors or cascade sensor, measuring the transmission spectrum loss of the liquid to be tested by a spectrometer, and recording the resonance wavelength positions lambda of two loss peaksAAnd λB。
S5: by z ═ λAThe intersection of the plane and the curved surface P obtains a curve l1。
S6: by z ═ λBThe intersection of the plane and the curved surface Q obtains another curve l2。
S7: respectively drawing a curve l on the xoy plane1、l2And obtaining the intersection point of the two curves, wherein the x-axis coordinate of the intersection point is the chiral parameter of the liquid to be detected, and the y-axis coordinate is the refractive index, the temperature or the concentration of the liquid to be detected.
Compared with the prior art of chiral parameter sensing, the method has the following advantages:
the invention utilizes the optical fiber sensor with a complex structure (such as photonic crystal fiber and long-period fiber grating sensor) to carry out sensing detection on the chiral parameters, and makes up for the defect of lower sensing sensitivity of the chiral parameters at present. The sensitivity of the D-type photonic crystal optical fiber sensor in the specific implementation case of the invention to the characteristic parameter sensing can reach 11108nm/chirality at most, and the sensitivity of the D-type photonic crystal optical fiber sensor can be further improved along with the structural optimization of the sensor.
The method provided by the invention is combined with a wave equation and a numerical calculation method under a chiral medium model to perform simulation calculation on the optical fiber sensor with the complex structure, and overcomes the defect that the complex structure cannot be simulated in the conventional chiral parameter sensing calculation method. In the specific implementation case of the invention, the wave equation under the Paster chiral medium model is adopted to calculate the chiral sensing characteristics of the sensor. Besides, wave equations under other chiral medium models can also be applied to the combination with the numerical calculation method in the invention, so that more chiral parameter sensing researches can be carried out.
The invention combines a numerical calculation method and a graphical method, and realizes the simultaneous sensing of the chiral parameters and the parameters such as refractive index, temperature or concentration. In the current research on sensing chiral parameters, dual-parameter sensing of chiral parameters and temperature or concentration is still in the blank stage. Temperature and concentration are important parameters of the medicine, namely the liquid to be detected, and the realization of double-parameter sensing of the chiral parameters and the temperature or the concentration has important significance on the research of the characteristics of the chiral medicine.
Drawings
FIG. 1 is a cross-sectional structure diagram of an optical fiber sensor, wherein (a) is a D-type photonic crystal optical fiber sensor, and (b) is a common D-type optical fiber sensor.
FIG. 2 is a three-dimensional structure diagram of a D-type photonic crystal fiber sensor. Coating a layer of gold on the upper layer of the section, wherein the upper part of the gold layer is the liquid to be detected of the chiral medicine.
Fig. 3 is a cross-sectional diagram of curved surfaces of two optical fiber sensors obtained by simulation calculation in an embodiment, wherein (a) is a cross-sectional diagram of a D-type photonic crystal optical fiber sensor, and (b) is a cross-sectional diagram of a common D-type optical fiber sensor.
Fig. 4 is a projection line of the sectional line of the two curved surfaces in fig. 3 on the xoy plane and an intersection point of the two projection lines.
Detailed Description
The present embodiment takes two types of optical fiber sensors as an example, and the method for sensing the chiral parameter and the refractive index by using two types of optical fiber sensors is described with reference to the accompanying drawings, so as to more clearly understand the features and advantages of the present invention.
Particularly, the dual-parameter sensing with chiral parameters by using the cascade sensor has the same sensing principle with the two optical fiber sensors, and the sensing steps of temperature and concentration and refractive index are the same.
Taking the Paster chiral medium model as an example, the method comprises the following steps:
and S1, selecting the two optical fiber sensor structures as a D-type photonic crystal fiber and a common D-type optical fiber respectively.
And S2, simulating the two high-sensitivity optical fiber sensors by adopting a numerical method based on the wave equation of the chiral medium of the Paster model. And calculating physical quantities including the near field containing chiral parameters, the complex effective mode refractive index, the limiting loss, the resonance wavelength of a loss peak and the like. Wherein the wave equation under the Paster chiral medium model is
Wherein E is the electric field intensity, omega is the angular frequency, gamma is the chiral parameter, epsilon is the dielectric constant, mu is the magnetic conductivity, epsilon0Dielectric constant under vacuum, μ0The permeability under vacuum condition.
Wave equation and electromagnetic field vector derivation process of Paster chiral medium
The constitutive relation of the bi-anisotropic medium is:
wherein E is the electric field intensity, D is the electric displacement vector, H is the magnetic field intensity, B is the magnetic induction intensity,
in order to be the dielectric constant of the tensor,
in order to be the permeability of the tensor,
being the electromagnetic tensor in the electrical displacement vector constitutive relation,
is the electromagnetic tensor in the magnetic induction strength constitutive relation.
The passive frequency domain maxwell's equations can be expressed as:
the equation of the chiral medium wave about the electric field E can be derived from equations (1) and (2):
wherein
When the constitutive relation is a Paster media model,
and
when the magnetic flux is both scalar, the electric displacement vector and the magnetic induction intensity are,
where γ is a chiral parameter, the wave equation becomes:
the electric field E can be solved by equation (5), and further:
s3, performing simulation calculation on the two optical fiber sensors by combining a wave equation under a Paster chiral medium model and a finite element and other numerical calculation methods, namely analyzing the sensing characteristics of the chiral parameters of the liquid to be measured in the chiral medium, and designing the specific structures of the two optical fiber sensors, wherein the specific design structure schematic diagrams are shown in FIG. 1 and FIG. 2.
And calculating the limiting loss of the wavelength under different chiral parameters and refractive indexes, and recording the resonance wavelength of the loss peak under different conditions.
The limiting loss is calculated by
αc＝2π×8.686×Im(neff)(dB/m) (7)
Wherein n iseffIs the effective mode index.
And calculating the limiting loss resonance peak of different chiral parameters and refractive index sensors. Taking the resonance wavelength of a loss peak as z-axis data, the chiral parameter as x-axis data and the refractive index as y-axis data, and drawing two three-dimensional surface graphs by an interpolation method to respectively obtain S1And S2As shown in fig. 3.
S4, preparing the two optical fiber sensors.
S5，Preparing the solution to be detected with different proportions of enantiomer contents. And (4) building a test platform, and respectively testing the two sensors. Measuring the transmission spectrum loss of the liquid to be measured by a spectrometer, and recording the wavelength positions lambda of two resonance peaksAAnd λB；
S6, testing the liquid to be tested by using two optical fiber sensors, and measuring to obtain the lambda corresponding to the resonance peakAAnd λBThen respectively using z ═ λAAnd z ═ λBTwo planes and a curved surface S1And S2Crossing to obtain two curves l1、l2As shown in fig. 3.
Respectively drawing a curve l on the xoy plane1、l2And obtaining the intersection point of the two curves, wherein the x-axis coordinate of the intersection point is the chiral parameter of the liquid to be detected, and the y-axis coordinate is the refractive index of the liquid to be detected, as shown in fig. 4.
Claims (1)
1. A method for realizing simultaneous sensing of dual parameters containing chiral parameters based on an optical fiber sensor is characterized by comprising the following steps:
s1: selecting A, B type optical fiber sensors with different sensitivities;
s2: by combining a wave equation under a chiral medium model with a finite element numerical calculation method, when different chiral parameters are calculated in a simulation mode, the A-type and B-type optical fiber sensors under different refractive indexes, temperatures or concentrations contain the loss resonance peak wavelength of the chiral parameters; at a loss resonance peak wavelength ofzAxial data, chiral parameters ofxAxial data, refractive index, temperature or concentration ofyThe axis data is respectively drawn into a three-dimensional surface graph P and a three-dimensional surface graph Q corresponding to the A, B type optical fiber sensors by an interpolation method;
wherein, the wave equation of the Paster chiral medium model is as follows:
wherein
For the strength of the electric field,
in order to be the angular frequency of the frequency,
in order to obtain the chiral parameters, the method comprises the following steps of,
in order to have a dielectric constant,
in order to have a magnetic permeability,
is a dielectric constant under a vacuum condition,
magnetic permeability under vacuum condition;
s3: respectively preparing A, B type two optical fiber sensors or a cascade A, B type two optical fiber sensors;
s4: preparing solutions to be detected with different proportions of enantiomer contents; building a test platform, respectively testing in A, B type two sensors or cascade sensor, measuring the transmission spectrum loss of the liquid to be tested by a spectrometer, and recording the wavelength positions of two loss resonance peaksλ A Andλ B ；
s5: by using
The intersection of the plane and the three-dimensional curved surface graph P obtains a curvel 1；
S6: by using
The plane is intersected with the three-dimensional curved surface graph Q to obtain another curvel 2；
S7: in thatxoyDrawing curves on the plane respectivelyl 1、l 2To obtain the intersection point of the two curvesxThe axial coordinate is the chiral parameter of the liquid to be detected,ythe axis coordinate is the refractive index, temperature or concentration of the liquid to be measured.
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