CN110478512A - Chitosan promotees to be cured layer and chitosan hemostatic layer combine dressing - Google Patents
Chitosan promotees to be cured layer and chitosan hemostatic layer combine dressing Download PDFInfo
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- CN110478512A CN110478512A CN201711357577.8A CN201711357577A CN110478512A CN 110478512 A CN110478512 A CN 110478512A CN 201711357577 A CN201711357577 A CN 201711357577A CN 110478512 A CN110478512 A CN 110478512A
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- China
- Prior art keywords
- chitosan
- layer
- combine dressing
- woven fabrics
- hemostatic
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
Promote to be cured layer and chitosan hemostatic layer combine dressing the present invention relates to a kind of chitosan, the chitosan combine dressing is the layer structure for including functional layer, and the functional layer promotees to be cured layer by chitosan and chitosan hemostatic layer is combined.The combine dressing plays effect by directly contacting with erythrocyte and blood platelet, independent of intracorporal hemostatic mechanism；And allergy will not be caused, heat will not be discharged, can be played a role in the case where hypothermia.Chitosan combine dressing of the present invention is suitable for gynaecology and obstetrics operation, hysteroscope invasive surgery, general surgery, orthopaedics style of opening wound, beauty and shaping, Emergency call wound, superficial skin ulcer etc. and various puncture, conduit, the wound for setting pipe are fixed, nurses and the nursing and dressing of the wounds surface of a wound such as dressing, and personal scratch, contusion, knife wound and small-area burn.Have the function of that hemostasis, rush are cured, ease pain, antibacterial and inhibition scar generate.
Description
Technical field:
The invention belongs to the technical fields of hemostatic material, more particularly, it relates to a kind of for promoting wound to be cured
The chitosan combine dressing of conjunction.
Background technique:
Skin is the vitals of human body, it plays control body temperature, prevents infection, the effect of immune and sensing.Due to wound,
The reasons such as scratch, exanthemv and burn, may cause the large range damage of skin.Bacterium sense is easily caused after skin damage evil
Dye, body fluid are lost and cause complication.Wound dressing is generallyd use in the prior art to protect wound, is absorbed sepage, is prevented
Only wound infection, the healing for maintaining the moist environment of wound and promoting wound.And there is following requirement for wound dressing: 1) having
With softness similar in human skin, certain form and intensity are also able to maintain when wet；2) it is able to maintain the wet of the surface of a wound
Environment has the preferable ability for absorbing wound exudate, and by certain gas permeability；3) dressing is nontoxic, does not have to human body
Harmful reaction and stimulation and it is necessary to bacterium can be prevented to enter the surface of a wound to prevent major structure into superinfection, no heat source；4) it is preferably formed with
The effects of hemostasis, analgesic, it can promote granulation growth and skin regeneration, healing acceleration reduces scar；5) excellent storage stability, tool
There is degradability.Chitin is widely present in the shell of lower animal, especially arthropod and lower animal or plant
Cell wall in, such as can from the shell of the shellfish such as shrimp, crab and bacterium, algae rudimentary plant cell wall in extract
Natural macromolecular material out is the second largest bio-regeneration resource that cellulose is only second in nature.Chitosan is chitin
Deacetylated product, be unique alkaline polysaccharide in nature.In general, the N- acetyl group of chitin sloughs 50% or more
Chitosan can be become.Chitin and chitosan be in nature in the form of coexisting existing for, contain in natural chitin
There is a chitosan, natural chitosan also contains chitin in nature.
In recent years, chitin and chitosan has attracted increasing attention in the application of technical field of biological material, applies in wound
The fields such as material, medical absorbable suture, sustained-release drug carrier, enzyme fix, coagulant and anticoagulant, anticarcinogen, slimming drugs
Application have research, and chitin and chitosan is due to having unique and excellent physiological activity, in terms of wound dressing
Research is increasingly becoming its in biomaterial application study hot spot.Energy when the discovery chitosan such as Allen and wound contact
Play the role of refrigerant and comfortable moisturizing.Azad A K chitosan handles wound, and discovery chitosan can accelerate III collagen egg
White secretion is to promote the formation of granulation tissue and epithelial tissue.Animal experiments show that chitosan can inhibit I in wound
The generation of type ossein, and promote the formation of granulation tissue and epithelial tissue, the shrinkage degree of wound is reduced, to inhibit scar
Formation.Okamoto etc. confirms that chitosan plays the role of accelerating hemostasis, has aggtegation to humans and animals blood rbc.Shell
In glycan molecule chain the positively charged muramic acid negatively charged with cell surface attract each other and adhere to, cause red blood cell poly-
Collection, to play anastalsis.The discovery such as Allen, chitin and chitosan is to such as epidermis of bacterium existing for general human epidermal
Pseudomonas aeruginosa, the staphylococcus aureus that staphylococcus, Escherichia coli and tropical Candida albicans and burn patient easily occur
There is significant inhibiting effect with suppurative infection of staphylococcus aureus etc..Currently, to the exact Antibacterial Mechanism of this kind of material
Also it is not very clear.It is generally acknowledged that: by chitosan molecule chain institute it is positively charged with microbial cell film negatively charged phase
Mutually attract, the protein of bacterium and other compositions is caused to reveal and generate antibacterial action.Although chitin and chitosan has good
Good physiological activity, but since they are formed by, film is more crisp, and mechanical property is bad, generally requires to change by being blended with other materials
It is apt to its mechanical property.Film is blended with glycerol for the keratin such as Tanabe, chitosan.Improve the strong of keratin membrane with chitosan
Degree, improves the flexibility of film with glycerol.Although the mechanics and chemical property that can improve chitosan is blended, also limit
The type of wound and position；Chitosan is blended with alginate by wet spinning for United States Patent (USP) US5597581 announcement, is worth
With hemostasis, mould proof, bacteriostasis property and dressing more can be promoted, blending dressing liquid absorption amount is 28 times of own wt.But only
The chronic wounds big suitable for sepage amount.
Summary of the invention:
In order to solve above-mentioned technical problem in the prior art, promote to be cured layer and shell the purpose of the present invention is to provide chitosan
Glycan hemostatic layer combine dressing.Chitosan combine dressing of the present invention, it is characterised in that: the combine dressing be include function
The layer structure of ergosphere, the functional layer promotees to be cured layer by chitosan and chitosan hemostatic layer is combined.Wherein, layered knot
Structure is by non-woven fabrics backing, and the chitosan being successively set on non-woven fabrics backing promotees to be cured layer, chitosan hemostatic layer and shield page composition.
Wherein, the chitosan promotees to be cured layer to be chitosan nonwoven layer, poly- selected from common chitosan non-woven fabrics or swollen molten shell
One or both of sugared non-woven fabrics.Wherein, the chitosan nonwoven layer with a thickness of 0.3-0.4mm.
Wherein, the chitosan hemostatic layer includes chitosan particle.
Wherein, the chitosan hemostatic layer is the chitosan particle coating for promoting to be cured on layer coated in the chitosan, thick
Degree is 0.5-1mm.
Wherein, the chitosan hemostatic layer is that chitosan particle is closed by gluing or coated in the gauze formed on gauze
Layer, wherein the thickness 0.6-0.8mm of the chitosan particle.
Wherein, the non-woven fabrics backing be silica gel non-woven fabrics or acrylate pressure sensitive adhesive non-woven fabrics, comfortable ventilating, it is flexible with
Body.
Wherein, the shield page is silicone oil paper, such as Ge Laxin silicone oil paper, remove facilitate it is smooth.
Wherein, the chitosan promotees the center of more laminated chitosan hemostatic layer and the center weight of non-woven fabrics backing and shield page
It closes.
Chitosan combine dressing of the present invention has the advantages that of the present invention compared with prior art
Chitosan combine dressing be suitable for the hemostasis of various wounds, wound site is unrestricted, and head, neck, chest, abdomen etc. are complete
Body can be used safely everywhere；Effective to the blood after test tube of hepari, the mechanism of action is independent of the coagulation factor in blood, effect
When do not discharge heat, not will bring about burns, there is no any restrictions to storage condition.
Detailed description of the invention:
Fig. 1 is the structural schematic diagram of chitosan combine dressing described in invention 1.Fig. 2 is that chitosan described in invention 2 is compound
The structural schematic diagram of dressing.Fig. 3 is the structural schematic diagram of chitosan combine dressing described in invention 3.Fig. 4 is described in invention 4
The structural schematic diagram of chitosan combine dressing.
Specific embodiment:
Below with reference to specific invention and Figure of description to the structure of chitosan combine dressing of the present invention and its
Performance is described further, with help those skilled in the art to inventive concept of the invention, technical solution have it is more complete,
Accurate and deep understanding.Chitosan combine dressing described in 1 invention 1 is invented, by back sheet 10, common chitosan non-woven fabrics
20, the stratified material that chitosan particle layer 30 and shield page 40 are constituted.Its functional component is chitosan nonwoven layer and chitosan
Granulosa does not contain other functional components.Thickness 0.3-0.4mm, the grammes per square metre 40-50g/m 2 of the common chitosan non-woven fabrics,
Moisture and sepage cannot be absorbed, ingredient is gucosamine polymer.The chitosan particle layer, ingredient are that rice yellow is deacetylated
Chitosan particle, pH5.0-7.0, water content < 10%.The chitosan particle coating layer thickness 0.5-1mm when making combine dressing.
The non-woven fabrics backing is silica gel non-woven fabrics or acrylate pressure sensitive adhesive non-woven fabrics, comfortable ventilating, flexible satellite.The shield page is
Lattice Racine silicone oil paper, remove facilitate it is smooth.In the present invention, the non-woven fabrics backing is identical with the shield size of page, and range is wide
5-15cm, length 5-25cm are spent, can be square, rectangle or ellipse；Common chitosan non-woven fabrics and chitosan particle layer
Width dimensions 3.5-12cm, length 3.5-22cm；Center and the nothing of the common chitosan non-woven fabrics and chitosan particle layer
The center of woven fabric backing and shield page is overlapped.Chitosan combine dressing described in 2 inventions 2 is invented, is gathered by back sheet 10, swollen molten shell
The stratified material that sugared non-woven fabrics 50, chitosan particle layer 30 and shield page 40 are constituted.Its functional component be chitosan nonwoven layer and
Chitosan particle layer does not contain other functional components.The swollen molten chitosan non-woven fabrics with a thickness of 0.3-0.4mm, grammes per square metre 40-
50g/m 2, can quickly absorb moisture and sepage, and liquid absorption amount is 10-20 times of own wt, pH value of solution 5.5-6.5, and ingredient is
Chitosan and its hydrochloride.The chitosan particle layer, ingredient are rice yellow chitosan particles, and pH5.0-7.0 is aqueous
Measure < 10%.The chitosan particle coating layer thickness 0.5-1mm when making combine dressing.The non-woven fabrics backing is silica gel non-woven fabrics
Or acrylate pressure sensitive adhesive non-woven fabrics, comfortable ventilating, flexible satellite.The shield page be Ge Laxin silicone oil paper, remove facilitate it is smooth.
In the present invention, the non-woven fabrics backing is identical with the shield size of page, and range wide 5-15cm, length 5-25cm can be positive
Rectangular, rectangle or ellipse；The width dimensions 3.5-12cm, length 3.5- of swollen molten chitosan non-woven fabrics and chitosan particle layer
22cm；The center of the swollen molten chitosan non-woven fabrics and chitosan particle layer is overlapped with the center of non-woven fabrics backing and shield page.It applies
Chitosan combine dressing described in example 3, by back sheet 10, common chitosan non-woven fabrics 20, chitosan gauze 60 and shield page 40
The stratified material of composition.The thickness 0.3-0.4mm of the common chitosan non-woven fabrics, grammes per square metre 40-50g/m 2 cannot absorb
Moisture and sepage, ingredient are gucosamine polymer.Chitosan gauze is to bond chitosan particle by viscose
In gauze surface, thickness 0.6-0.8mm, liquid absorption amount is not less than 5 times of self gravity.Hemostasis granules are disposed from wound
There are confirmation, the removing that residue can be easy in such a way that clear water or salt water rinse in clinic.Hemostasis granules are that rice is yellow
The particle of color, pH5.0-7.0, water content < 10%, particle diameter size 0.2-2mm, in blood coagulating time 300 seconds.It is described
Non-woven fabrics backing is silica gel non-woven fabrics or acrylate pressure sensitive adhesive non-woven fabrics, comfortable ventilating, flexible satellite.The shield page is lattice drawing
Pungent silicone oil paper, remove facilitate it is smooth.The non-woven fabrics backing is identical with the shield size of page, range wide 5-15cm, length 5-
25cm can be square, rectangle or ellipse；Chitosan promotees the width dimensions 3.5-12cm for being cured layer and chitosan hemostatic layer,
Length 3.5-22cm；The more center of functional layer and hemostatic function layer that promotees is overlapped with the center of non-woven fabrics backing and shield page.Hair
Chitosan combine dressing described in bright 4, by back sheet 10, common chitosan non-woven fabrics 20, swollen molten chitosan non-woven fabrics 50, shell
The stratified material that glycan gauze 60 and shield page 40 are constituted.The thickness 60.3-0.4mm of the common chitosan non-woven fabrics；Swollen molten shell
Glycan non-woven fabrics with a thickness of 0.3-0.4mm.Chitosan gauze is that chitosan particle is bonded in gauze by viscose
Surface, thickness 0.6-0.8mm, liquid absorption amount are not less than 5 times of self gravity.The non-woven fabrics backing is silica gel non-woven fabrics or third
Olefin(e) acid pressure sensitive adhesive non-woven fabrics, comfortable ventilating, flexible satellite.The shield page be Ge Laxin silicone oil paper, remove facilitate it is smooth.The nothing
Woven fabric backing is identical with the shield size of page, range wide 5-15cm, length 5-25cm, can be square, rectangle or ellipse
Shape；Chitosan promotees the width dimensions 3.5-12cm, length 3.5-22cm of being cured layer and chitosan hemostatic layer；It is described promote be cured functional layer and
The center of hemostatic function layer is overlapped with the center of non-woven fabrics backing and shield page.
Chitosan combine dressing of the present invention applies the chitosan particle by promoting to be cured on layer in the chitosan,
It can be by directly contacting to play effect with erythrocyte and blood platelet, and form a kind of cross one another obstruction row
Blood coagulation, absorb blood after and tough and tensile gel can be generated, anastalsis is independent of intracorporal hemostatic mechanism；And it has
The other components of ingredient and functional component not other than chitosan-containing are imitated, allergy will not be caused, and while stopping blooding and promoting to be cured
Heat will not be discharged, can be played a role in the case where hypothermia (18~25 DEG C), it is easy to use.Chitosan combine dressing
Suitable for gynaecology and obstetrics operation, hysteroscope invasive surgery, general surgery, orthopaedics style of opening wound, beauty and shaping, Emergency call wound, shallow
Table skin ulcer (contain diabetic ulcer) etc. and various puncture, conduit, the wound for setting pipe fix, nurse and dressing, and personal transport
The nursing and dressing of the wounds surface of a wound such as dynamic scratch, contusion, knife wound and small-area burn.With hemostasis, promote more, analgesia, antibacterial and
The effect for inhibiting scar to generate.
In the present invention, it is described for the ordinary skill in the art, specific invention is only in conjunction with attached drawing pair
The present invention is exemplarily described, it is clear that present invention specific implementation is not subject to the restrictions described above, as long as using this hair
The improvement for the various unsubstantialities that bright method concept and technical solution carry out, or it is not improved by design and technology of the invention
Scheme directly applies to other occasions, within the scope of the present invention.
Claims (10)
1. chitosan promote be cured layer and chitosan hemostatic layer combine dressing, it is characterised in that: the combine dressing be include functional layer
Layer structure, the functional layer is promoted to be cured layer and chitosan hemostatic layer by chitosan to be combined.
2. chitosan combine dressing according to claim 1, it is characterised in that: layered structure by non-woven fabrics backing,
Promote to be cured layer, chitosan hemostatic layer and shield page composition with the chitosan being successively set on non-woven fabrics backing.
3. according to right want 1 or 2 described in chitosan combine dressing, it is characterised in that: the chitosan promotees to be cured layer to be chitosan
Nonwoven layer is selected from one or both of common chitosan non-woven fabrics or swollen molten chitosan non-woven fabrics.
4. chitosan combine dressing according to claim 3, it is characterised in that: the chitosan nonwoven layer with a thickness of
0.3-0.4mm。
5. chitosan combine dressing according to claim 3, it is characterised in that: the chitosan hemostatic layer includes deacetylated
Chitosan.
6. chitosan combine dressing according to claim 5, it is characterised in that: the chitosan hemostatic layer is coated in institute
It states chitosan and promotees the chitosan particle coating being cured on layer.
7. chitosan combine dressing according to claim 6, it is characterised in that: the chitosan particle coating layer thickness is
0.5-1mm。
8. chitosan combine dressing according to claim 5, it is characterised in that: the chitosan hemostatic layer is chitosan
Grain is closed by gluing or coated in the chitosan gauze layer formed on gauze.
9. chitosan combine dressing according to claim 2, it is characterised in that: the size of the non-woven fabrics backing and shield page
It is identical；It is identical with the size of chitosan hemostatic layer that the chitosan promotees more layer.
10. chitosan combine dressing according to claim 9, it is characterised in that: the chitosan promotees to be cured layer and chitosan
The center of hemostatic layer is overlapped with the center of non-woven fabrics backing and shield page.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711357577.8A CN110478512A (en) | 2017-12-16 | 2017-12-16 | Chitosan promotees to be cured layer and chitosan hemostatic layer combine dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711357577.8A CN110478512A (en) | 2017-12-16 | 2017-12-16 | Chitosan promotees to be cured layer and chitosan hemostatic layer combine dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110478512A true CN110478512A (en) | 2019-11-22 |
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ID=68543646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711357577.8A Pending CN110478512A (en) | 2017-12-16 | 2017-12-16 | Chitosan promotees to be cured layer and chitosan hemostatic layer combine dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110478512A (en) |
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2017
- 2017-12-16 CN CN201711357577.8A patent/CN110478512A/en active Pending
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Application publication date: 20191122 |