CN103536955A - Composite chitosan dressing - Google Patents
Composite chitosan dressing Download PDFInfo
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- CN103536955A CN103536955A CN201310539212.2A CN201310539212A CN103536955A CN 103536955 A CN103536955 A CN 103536955A CN 201310539212 A CN201310539212 A CN 201310539212A CN 103536955 A CN103536955 A CN 103536955A
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Abstract
The invention relates to a composite chitosan dressing, and belongs to the technical field of hemostatic materials. The composite chitosan dressing is of a layered structure with a functional layer, wherein the functional layer is formed by compounding a chitosan recovery promoting layer and a chitosan hemostasis layer; the functional components of the functional layer contain no other components except for chitosan. The composite dressing plays the role by directly contacting with red blood cells and blood platelets without depending on in-vivo hemostasis mechanisms, moreover no irritability is caused, no heat is released, and the role can come into play under the condition of low body temperature. The composite chitosan dressing provided by the invention is applicable to gynaecology and obstetrics surgery, endoscope minimally invasive surgery, general surgery department surgery, open type wound of orthopaedics departments, plastic and aesthetic surgery, outpatient service and emergency treatment trauma, superficial skin ulcer and the like, and can be applicable to wound fixation, nursing and dressing change of various puncture, conduits and cathetering, and to nursing and dressing change of wound and wound surfaces of individual bruise, contusion, knife wound, small-area burn and the like. The composite chitosan dressing has the effects of hemostasis, heal prompting, analgesia, antibiosis and scar generation prevention.
Description
Technical field
The invention belongs to the technical field of hemostatic material, in particular, the present invention relates to a kind of for promoting the chitosan combine dressing of wound healing.
Background technology
Skin is the vitals of human body, and it plays and control body temperature, protects from infection, immunity and sensing effect.Due to reasons such as wound, scratch, skin ulceration and burns, may cause the large range damage of skin.After skin is hurt, easily cause antibacterial to infect, body fluid runs off and lead to complications.In prior art, conventionally adopt wound dressing to protect wound, absorb sepage, prevent wound infection, maintain the moist environment of wound and promote the healing of wound.And have following requirement for wound dressing: 1) there is the softness close with human body skin, when moistening, also can keep certain form and intensity; 2) can keep the moist environment of wound surface, have the ability of good absorption wound exudate, and by certain breathability; 3) dressing is nontoxic, the reaction that human body is not harmful to and stimulation, and must be able to stop antibacterial to enter wound surface in case major structure becomes superinfection, without thermal source; 4) preferably have the effects such as hemostasis, pain relieving, can promote granulation growth and skin regeneration, healing acceleration, reduces cicatrix; 5) excellent storage stability, has degradability.
Chitin is extensively present in lower animal, particularly in arthropodan shell, and in the cell wall of lower animal or plant, such as the natural macromolecular material that can extract from the cell wall of the shells of the Crustaceans such as shrimp, Eriocheir sinensis and bacterium, algae rudimentary plant, be that occurring in nature is only second to cellulosic second largest bio-regeneration resource.Chitosan is the deacetylated product of chitin, is the unique alkaline polysaccharide of occurring in nature.In general, the N-acetyl group of chitin is sloughed more than 50% and just can be become chitosan.Chitin and chitosan exist with the form of coexisting at occurring in nature, all contain chitosan in natural chitin, and the natural chitosan of occurring in nature also contains chitin.
In recent years, chitin and chitosan causes people's attention day by day in the application of technical field of biological material, at wound dressing, medical absorbable suture, slow releasing pharmaceutical carrier, enzyme, fix, the application in the field such as coagulant and anticoagulant, anticarcinogen, appetrol has research, and the chitin and chitosan physiologically active excellent owing to having uniqueness becomes its focus in biomaterial applied research gradually in the research aspect wound dressing.The discovery chitosans such as Allen can play refrigerant and comfortable skin moistening effect while contacting with wound.Azad A K treatment with chitosan wound, thus find that chitosan can accelerate the secretion promotion granulation tissue of III collagen protein and the formation of epithelial tissue.Zoopery shows, chitosan can suppress the generation of I type ossein in wound, and promotes the formation of granulation tissue and epithelial tissue, reduces the shrinkage degree of wound, thereby suppresses the formation of cicatrix.The confirmation chitosans such as Okamoto have the effect of the hemostasis accelerated, and humans and animals blood rbc is had to aggregation.In chitosan molecule chain the electronegative 3-O-.alpha.-carboxyethyl-D-glucosamine. of positively charged and cell surface attract each other and adhere to, cause erythrocyte aggregation, thus the anastalsis of playing.
The discoveries such as Allen, the antibacterial that chitin and chitosan exists general human epidermal has significant inhibitory action as bacillus pyocyaneus, staphylococcus aureus and the suppurative infection of staphylococcus aureus etc. that staphylococcus epidermidis, escherichia coli and tropical Candida albicans and burn patient are prone to.At present, the definite Antibacterial Mechanism of this class material is also not very clear.It is generally acknowledged: because institute in chitosan molecule chain is positively charged and electronegative the attracting each other of microbial cell film, cause the protein of antibacterial and other compositions to be revealed and generation antibacterial action.
Although chitin and chitosan has good physiologically active, because their formed films are more crisp, mechanical property is bad, often needs by improving its mechanical property with other material blend.Keratin, chitosan and glycerol blend masking for Tanabe etc.With chitosan, improve keratin film strength, with glycerol, improve the pliability of film.Although blend can improve mechanics and the chemical property of chitosan, also limited type and the position of wound; US Patent No. 5597581 is announced chitosan with alginate by wet spinning blend, the dressing of be worth thering is hemostasis, mildew-resistant, bacteriostasis property can urging being healed, and blend dressing liquid absorption is 28 times of own wt.But be only applicable to the chronic wounds that sepage amount is large.
Summary of the invention
In order to solve above-mentioned technical problem of the prior art, the object of the present invention is to provide a kind of chitosan combine dressing.
Chitosan combine dressing of the present invention, is characterized in that: described combine dressing is the layer structure that comprises functional layer, and described functional layer is composited by the short more layer of chitosan and chitosan hemostatic layer.
Wherein, layered structure is by non-woven fabrics backing, and is successively set on chitosan short more layer, the chitosan hemostatic layer on non-woven fabrics backing and protects page and form.
Wherein, described functional layer other component beyond chitosan-containing not.
Wherein, the short more layer of described chitosan is chitosan nonwoven layer, is selected from one or both in the swollen molten chitosan non-woven fabrics that does not absorb the chitosan non-woven fabrics of moisture and sepage or can absorb fast moisture and sepage.
Wherein, the described chitosan non-woven fabrics that does not absorb moisture and sepage, its chitosan more than 98% being formed by chitin deacetylation prepares, and main component is glucamine polymer.The described thickness that does not absorb the chitosan non-woven fabrics of moisture and sepage is 0.3-0.4mm, grammes per square metre 40-50g/m
2.Described glucamine polymer is by the polymer of an amino compound formation replacing by a hydroxyl of glucose.
Wherein, the described swollen molten chitosan non-woven fabrics that can absorb fast moisture and sepage, its main component is chitosan and hydrochlorate thereof, pH is 5.5～6.5.The described thickness that can absorb fast the swollen molten chitosan non-woven fabrics of moisture and sepage is 0.3-0.4mm, grammes per square metre 40-50g/m
2.Described swollen molten chitosan non-woven fabrics can absorb moisture and sepage fast, and liquid absorption is 10-20 times of own wt.
Wherein, described chitosan hemostatic layer comprises chitosan particle, and its particle diameter size is 0.2～2mm, and described chitosan is chitosan, and pH value is 5.0～7.0, and water content is less than 10%.On the short layer of healing of described chitosan, apply described chitosan particle, thereby described combine dressing is by directly contacting performance effect with erythrocyte and platelet, and form the blood coagulation of a kind of cross one another obstruction row, after absorbing blood and can produce tough and tensile gel, anastalsis does not rely on the hemostatic mechanism in body; And its effective ingredient and functional component other component beyond chitosan-containing not, can not cause allergy, and hemostasis and short can release heat in more, can play a role in hypothermia (18～25 ℃) in the situation that, easy to use.
Wherein, described chitosan hemostatic layer is the chitosan particle coating being coated on the short more layer of described chitosan, and its thickness is 0.5-1mm.
Wherein, described chitosan hemostatic layer is that chitosan particle is closed or be coated in the gauze layer forming on gauze by gluing, the thickness 0.6-0.8mm of wherein said chitosan particle.
Wherein, described non-woven fabrics backing is silica gel non-woven fabrics or acrylate pressure sensitive adhesive non-woven fabrics, comfortable ventilating, pliable and tough satellite.
Wherein, described in protect page for silicone oil paper, Ge Laxin silicone oil paper for example, remove facilitate smooth.
Wherein, the center of the short more axisymmetrical laminated shell polysaccharide hemostatic layer of described chitosan and non-woven fabrics backing and the center superposition that protects page.
Chitosan combine dressing of the present invention, compared with prior art, has following beneficial effect:
Chitosan combine dressing of the present invention, by apply described chitosan particle on the short layer of healing of described chitosan, is applicable to the hemostasis of various wounds, and wound site is unrestricted, and the whole bodies such as head, cervical region, chest, abdominal part all can be used safely everywhere; Effective to the blood after heparinization, the mechanism of action does not rely on the thrombin in blood, makes used time release heat not, can not produce and burn, to storage condition without any restriction.
The specific embodiment
Below with reference to specific embodiment, the composition of chitosan combine dressing of the present invention, structure and performance thereof are described further, to help those skilled in the art to have more complete, accurate and deep understanding to inventive concept of the present invention, technical scheme.
Embodiment 1
Chitosan combine dressing described in embodiment 1, it is by backing layer, chitosan short more layer, chitosan hemostatic layer and protect the stratified material that page forms.Its functional component is chitosan nonwoven layer and chitosan particle layer, does not contain other functional component.When the short layer material of healing of described chitosan is chitosan non-woven fabrics, its thickness 0.3-0.4mm, grammes per square metre 40-50g/m
2, described chitosan is the chitosan that chitin deacetylation more than 98% is prepared from, and can not absorb moisture and sepage, its composition is glucamine polymer.When described chitosan is short more when layer material is swollen molten chitosan non-woven fabrics, its thickness 0.3-0.4mm, grammes per square metre 40-50g/m
2, can absorb fast moisture and sepage, liquid absorption is 10-20 times of own wt, its pH value of solution 5.5-6.5, composition is chitosan and hydrochlorate thereof.Described chitosan hemostatic layer is chitosan particle, and composition is the yellow chitosan granule of rice, particle diameter size 0.2-2mm, and pH5.0-7.0, water content < 10%.Chitosan particle coating layer thickness 0.5-1mm when making combine dressing.Described non-woven fabrics backing is silica gel non-woven fabrics or acrylate pressure sensitive adhesive non-woven fabrics, comfortable ventilating, pliable and tough satellite.The described page that protects is for Ge Laxin silicone oil paper, remove facilitate smooth.In the present embodiment, described non-woven fabrics backing and protect page measure-alike, its scope width 5-15cm, length 5-25cm, can be square, rectangle or ellipse; The width dimensions 3.5-12cm of the short more layer of chitosan and chitosan hemostatic layer, length 3.5-22cm; Described short more functional layer and hemostatic function Ceng center and non-woven fabrics backing and the center superposition that protects page.
Embodiment 2
Chitosan combine dressing described in embodiment 2 is by backing layer, chitosan non-woven fabrics, chitosan gauze and protect the stratified material that page forms.The chitosan non-woven fabrics that described chitosan nonwoven cloth material is non-absorbency, thickness 0.3-0.4mm, grammes per square metre 40-50g/m
2, described chitosan is the chitosan that chitin deacetylation is prepared from after more than 98%.In addition, when described chitosan non-woven fabrics is swollen molten chitosan non-woven fabrics, thickness 0.3-0.4mm, grammes per square metre 40-50g/m
2, liquid absorption is 15 times of own wt, pH5.5-6.5, and composition is chitosan and hydrochlorate thereof.Described chitosan non-woven fabrics can be selected from a kind of in the chitosan non-woven fabrics of non-absorbency and swollen molten chitosan non-woven fabrics, also can the two jointly use.Chitosan gauze is that chitosan granule is bonded in to gauze surface by viscose, thickness 0.6-0.8mm, and liquid absorption is not less than 5 times of own wt.From wound, hemostasis granules is disposed also clinical and had a confirmation, residue can be by the easy removing of mode of clear water or normal saline washing.Hemostasis granules is the granule of rice yellow, pH5.0-7.0, and water content < 10%, and particle diameter size 0.2-2mm, in blood coagulating time 300 seconds.Described non-woven fabrics backing is silica gel non-woven fabrics or acrylate pressure sensitive adhesive non-woven fabrics, comfortable ventilating, pliable and tough satellite.The described page that protects is for Ge Laxin silicone oil paper, remove facilitate smooth.Described non-woven fabrics backing and protect page measure-alike, its scope width 5-15cm, length 5-25cm, can be square, rectangle or ellipse; The width dimensions 3.5-12cm of the short more layer of chitosan and chitosan hemostatic layer, length 3.5-22cm; Center and the non-woven fabrics backing and the center superposition that protects page of the short more layer of described chitosan and chitosan hemostatic layer.
Chitosan combine dressing of the present invention by applying described chitosan particle on the short layer of healing of described chitosan, thereby can be by directly contacting performance effect with erythrocyte and platelet, and form the blood coagulation of a kind of cross one another obstruction row, after absorbing blood and can produce tough and tensile gel, anastalsis does not rely on the hemostatic mechanism in body; And its effective ingredient and functional component other component beyond chitosan-containing not, can not cause allergy, hemostasis and short can release heat in more, can play a role in hypothermia (18～25 ℃) in the situation that, easy to use.And described chitosan combine dressing is applicable to the opening wound of obstetrics and gynecology operation, chamber mirror invasive surgery, general surgery, orthopaedics, beauty and shaping, door emergency treatment wound, shallow table skin ulcer (containing diabetic ulcer) etc. and various punctures, conduit, the wound of putting pipe is fixed, nurses and changes dressings, and the nursing of the wound wound surface such as individual sports scratch, contusion, knife injury and small-area burn and changing dressings, have hemostasis, short more, analgesia, antibiotic and suppress the effect that cicatrix generates.
For the ordinary skill in the art; specific embodiment is just exemplarily described the present invention; obviously specific implementation of the present invention is not subject to the restrictions described above; as long as adopted the improvement of the various unsubstantialities that method of the present invention design and technical scheme carry out; or without improving, design of the present invention and technical scheme are directly applied to other occasion, all within protection scope of the present invention.
Claims (10)
1. a chitosan combine dressing, is characterized in that: described combine dressing is the layer structure that comprises functional layer, and described functional layer is composited by the short more layer of chitosan and chitosan hemostatic layer.
2. chitosan combine dressing according to claim 1, is characterized in that: layered structure is by non-woven fabrics backing, and is successively set on chitosan short more layer, the chitosan hemostatic layer on non-woven fabrics backing and protects page and form.
3. chitosan combine dressing according to claim 1 and 2, it is characterized in that: the short more layer of described chitosan is chitosan nonwoven layer, is selected from one or both in the swollen molten chitosan non-woven fabrics that does not absorb the chitosan non-woven fabrics of moisture and sepage or can absorb fast moisture and sepage.
4. chitosan combine dressing according to claim 3, is characterized in that: the described chitosan non-woven fabrics that does not absorb moisture and sepage, and its chitosan more than 98% being formed by chitin deacetylation prepares, and main component is glucamine polymer.
5. chitosan combine dressing according to claim 3, is characterized in that: the described swollen molten chitosan non-woven fabrics that can absorb fast moisture and sepage; Its main component is chitosan and hydrochlorate thereof, and pH is 5.5～6.5.
6. according to the chitosan combine dressing described in claim 4 or 5, it is characterized in that: described chitosan non-woven fabrics and the described thickness that can absorb fast the swollen molten chitosan non-woven fabrics of moisture and sepage that does not absorb moisture and sepage is 0.3-0.4mm, grammes per square metre 40-50g/m
2.
7. chitosan combine dressing according to claim 1 and 2, it is characterized in that: described chitosan hemostatic layer comprises chitosan particle, its particle diameter size is 0.2～2mm, and described chitosan is chitosan, pH value is 5.0～7.0, and water content is less than 10%.
8. chitosan combine dressing according to claim 7, is characterized in that: described chitosan hemostatic layer is the chitosan particle coating being coated on the short more layer of described chitosan, and its thickness is 0.5-1mm.
9. chitosan combine dressing according to claim 7, is characterized in that: described chitosan hemostatic layer is that chitosan particle is closed or be coated in the gauze layer forming on gauze by gluing, the thickness 0.6-0.8mm of wherein said chitosan particle.
10. chitosan combine dressing according to claim 2, is characterized in that: the center of the short more axisymmetrical laminated shell polysaccharide hemostatic layer of described chitosan and non-woven fabrics backing and the center superposition that protects page.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310539212.2A CN103536955A (en) | 2013-11-05 | 2013-11-05 | Composite chitosan dressing |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310539212.2A CN103536955A (en) | 2013-11-05 | 2013-11-05 | Composite chitosan dressing |
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| CN103536955A true CN103536955A (en) | 2014-01-29 |
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| CN201310539212.2A Withdrawn CN103536955A (en) | 2013-11-05 | 2013-11-05 | Composite chitosan dressing |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104524619A (en) * | 2014-12-30 | 2015-04-22 | 东莞市鸿元医药科技有限公司 | Chitosan dressing and production process thereof |
| CN107551313A (en) * | 2017-08-17 | 2018-01-09 | 江南大学 | A kind of preparation method of the antibacterial anti-scar chitosan sponge dressing of double deck type waterproof |
| CN116355258A (en) * | 2021-12-20 | 2023-06-30 | 北京健康广济生物技术有限公司 | Preparation method of chitosan film and sodium carboxymethyl cellulose hydrogel burn dressing based on double-layer structure |
-
2013
- 2013-11-05 CN CN201310539212.2A patent/CN103536955A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104524619A (en) * | 2014-12-30 | 2015-04-22 | 东莞市鸿元医药科技有限公司 | Chitosan dressing and production process thereof |
| CN107551313A (en) * | 2017-08-17 | 2018-01-09 | 江南大学 | A kind of preparation method of the antibacterial anti-scar chitosan sponge dressing of double deck type waterproof |
| CN116355258A (en) * | 2021-12-20 | 2023-06-30 | 北京健康广济生物技术有限公司 | Preparation method of chitosan film and sodium carboxymethyl cellulose hydrogel burn dressing based on double-layer structure |
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Application publication date: 20140129 |