CN110476997A - A kind of mealybug insecticide - Google Patents
A kind of mealybug insecticide Download PDFInfo
- Publication number
- CN110476997A CN110476997A CN201910833888.XA CN201910833888A CN110476997A CN 110476997 A CN110476997 A CN 110476997A CN 201910833888 A CN201910833888 A CN 201910833888A CN 110476997 A CN110476997 A CN 110476997A
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- mealybug
- nimbin
- jervine
- carrier
- lecithin
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention provides a kind of mealybug insecticide, active constituent is made of nimbin and jervine, and the mass ratio of nimbin and jervine is 1: 30-40: 1.And specifically disclose the formula and preparation process of the insecticide carrier.Said preparation is compared with conventional liposome, except have the advantages that with skin affinity is good, in addition to safety and low toxicity, also have the characteristics such as high deformation, highly hydrophilic, high-effective penetrating, can efficiently the skin duct of its own small several times of penetration ratio and achieve the purpose that cutaneous penetration.
Description
Technical field
Invention belongs to field of pesticide preparation, and in particular to a kind of mealybug insecticide.
Background technique
Mealybug, Pseudococcidae;English name is generally called mealybugs, and small-sized sap-sacking insect belongs to mealybug category, is distributed
The whole world adapts to various environment.Female adult oval, is slow in action, and is about 1 centimeter, there is the glutinous powder of white in vitro.Mealybug female adult and larva
It is clustered in blade back.Male imago mesothorax has the fore wing of a pair of of prosperity, and there is flourishing gonad capsule at body end.It harms the crops, fruit tree, garden
Woods, forest and pasture.
Nimbin, English name: azadirachtin, English alias: Azadirachtin; Azadirachtin A;
Azadirachtin-A;Bioneem; CCIRS 9142; CCRIS 9142; EPA Pesticide Chemical Code
121701; HSDB 7372; NSC 368675; NeemAzal;CAS:11141-17-6, molecular formula: C35H44O16, molecule
Amount: 720.7143, physico-chemical property relative density: 1.513, purity: 95% ~ 99%, analysis method: HPLC-DAD or/and
HPLC-ELSD, identification method: mass spectrum (Mass), nuclear-magnetism (NMR), packaging: brown vial, standard pack 10mg,
20mg, 50mg；Nimbin belongs to tetracyclic triterpenoid, and chemical structure can substantially be divided into decahydronaphthalenes and tricyclic furans is left
Right two parts contain 16 chiral centres, including 7 quaternary carbons, 9 secondary carbons and 16 oxygen atoms altogether.
The main insecticidal action mechanism of nimbin is through polypide epidermis or to suck, itself hormone in vivo balance is destroyed, interior point
It is not normal to secrete system operating, metabolism, growth and development imbalance, brain and body functions disorder, so that reproductive function loses
It loses, cannot produce offspring, finally decline insect populations quantity.；It is mainly used for preventing and treating brassicaceous vegetable diamondback moth.
Jervine, Chinese synonym: Xi Daiding；Veratridine；Alkavervir；Sai Fanding；Four cut down fourth；Jervine；Black false hellebore spit of fland,
English name: VERATRINE, English synonym: SABADILLA TOTAL ALKALOIDS；VERATRINE；
asagraeaofficinalis；causticbarley；cevadilla；cevadinemixedwithveratridine；
ent123；Sabacide, No. CAS: 8051-02-3, molecular formula: C36H51NO11, molecular weight: 673.8, related category:
Alkaloids。
Jervine main chemical compositions are cevadine and veratridine.Flat acicular crystal.Veratrum alkaloid is present in lily
In section Veratrum and sabadilla platymiscium, the plant material as insecticide is mainly the seed of sabadilla and the root of white black false hellebore
Stem.Plant material is extracted through ethyl alcohol and is made.Plant insecticide has insect and tags and stomach poison function.It can be used for preventing and treating
The sanitary insect pests such as housefly, blattaria, lice, it can also be used to prevent and treat the agricultural pests such as cabbage caterpillar, aphid, leafhopper, thrips and stinkbug.
The main insecticidal action mechanism of jervine is through polypide epidermis or to suck into after digestive system, causes local stimulation,
Cause reflexive polypide excited, first inhibits polypide sensory nerve ending, it is rear to inhibit nervous centralis and cause pest dead；It is mainly used for
Prevent and treat cotton boll worm, cotten aphid and brassicaceous vegetable cabbage caterpillar.
The present invention combines the different drug of two kinds of mechanism of action by a certain percentage, and novel preparation capable of permeating skin transmitting has been made
Body, it has been investigated that it is significant for mealybug insecticidal action, pollution-free, green pesticide.And carrier (transfersomes)
Also known as flexible nano-liposomes are a kind of novel carrier for transdermal delivery, are that surface is added on the basis of conventional liposome to live
Property agent (such as cholate etc.) made of lipoid build up body.It is good, safe low with skin affinity except having compared with conventional liposome
Poison advantage outside, also have the characteristics such as high deformation, highly hydrophilic, high-effective penetrating, can efficiently penetration ratio its own
The skin duct of small several times and achieve the purpose that cutaneous penetration.By carrier Technology application in green pesticide of the present invention, effectively
Improve insecticidal effect of the invention.
Summary of the invention
The present invention is intended to provide a kind of, pollution-free, green pesticide significant for mealybug insecticidal action, specific open offer
The carrier formula and technique of a kind of mealybug insecticide.
For achieving the above object, a kind of mealybug insecticide of the present invention, the specific scheme is that
A kind of mealybug insecticide of the present invention, active constituent are made of nimbin and jervine, the matter of nimbin and jervine
Amount is than being 1: 30-40: 1.
A kind of mealybug insecticide of the present invention, the suitable dosage form have emulsion, and wettable powder, hangs water dispersible granules
Floating agent, oil-suspending agent, ultra low volume liquids, electrostatic oil agent or dry suspending agent, carrier.
A kind of mealybug insecticide of the present invention, the dosage form are carrier.
A kind of mealybug insecticide of the present invention, the carrier prescription weight percent are calculated as: nimbin 1-10%, black false hellebore
Alkali 1-10%, lecithin 10-30%, soybean lecithin 20-69%.
A kind of mealybug insecticide of the present invention, the carrier prescription weight percent are calculated as: nimbin 2-10%, black false hellebore
Alkali 2-10%, lecithin 10-15%, soybean lecithin 30-56%.
A kind of mealybug insecticide of the present invention, the carrier prescription weight percent are calculated as: nimbin 3.2%, jervine
9.6%, lecithin 12.9%, soybean lecithin 48.5%.
A kind of mealybug insecticide of the present invention, the carrier prescription weight percent are calculated as: nimbin 9.6%, jervine
3.2%, lecithin 12.9%, soybean lecithin 48.5%.
A kind of mealybug insecticide of the present invention, carrier the preparation method comprises the following steps:
1) soybean lecithin, lecithin, cholesterol, nimbin and jervine are dissolved in ethyl alcohol；
2) decompression rotary evaporation removes solvent, and lipid is made to form uniform film in bottle wall, and the hydration containing sodium taurocholate is added and is situated between
Matter abundant aquation lipid 2h under 37 °C is ultrasonically treated under ice bath to obtain the final product.
A kind of Pesticidal combination containing nimbin and jervine of the present invention is applied to prevention and treatment agricultural pests mealybug.
The advantages and beneficial effects of the present invention are:
(1) due to overcoming using nimbin and jervine compound formulation, single formulation effect is unstable to be lacked product of the present invention
Point combines nimbin and two kinds of jervine different insecticidal mechanisms, has apparent synergistic effect, to pests such as mealybug classes
Toxicity is stronger, can greatly improve insecticidal effect, significant to shorten onset time.
(2) nimbin and jervine are prepared into carrier, carrier has high deformation, highly hydrophilic, efficient
The characteristics such as permeability can faster penetrate pest skin, play the role of quick desinsection.
(3) nimbin, jervine come to extract for pure plant, and environmentally protective, containing benezene, is not producing and using
To operator and Environmental security in journey.
Specific embodiment
Following embodiment is only to further illustrate technical solution of the present invention, range that the invention is not limited in any way.
Embodiment 1
Carrier prescription:
Nimbin 3g
Jervine 1g
Soybean lecithin 4g
Cholesterol 8g
Sodium taurocholate 15g
Purified water adds to 100g
Preparation method:
1) soybean lecithin of recipe quantity, cholesterol, nimbin, jervine are dissolved in ethyl alcohol；
2) decompression rotary evaporation removes solvent, and lipid is made to form uniform film in bottle wall, and the hydration containing sodium taurocholate is added and is situated between
Matter abundant aquation lipid 2h under 37 °C, ultrasound is handled for 5-10 minutes under ice bath to obtain the final product.
Embodiment 2
Carrier prescription:
Nimbin 1g
Jervine 2g
Soybean lecithin 4g
Cholesterol 8g
Sodium taurocholate 15g
Purified water adds to 100g
Preparation method:
1) soybean lecithin of recipe quantity, cholesterol, nimbin, jervine are dissolved in ethyl alcohol；
2) decompression rotary evaporation removes solvent, and lipid is made to form uniform film in bottle wall, and the hydration containing sodium taurocholate is added and is situated between
Matter abundant aquation lipid 2h under 37 °C, ultrasound is handled for 5-10 minutes under ice bath to obtain the final product.
Embodiment 3
Carrier prescription:
Nimbin 1g
Jervine 3g
Soybean lecithin 4g
Cholesterol 8g
Sodium taurocholate 15g
Purified water adds to 100g
Preparation method:
1) soybean lecithin of recipe quantity, cholesterol, nimbin, jervine are dissolved in ethyl alcohol；
2) decompression rotary evaporation removes solvent, and lipid is made to form uniform film in bottle wall, and the hydration containing sodium taurocholate is added and is situated between
Matter abundant aquation lipid 2h under 37 °C, ultrasound is handled for 5-10 minutes under ice bath to obtain the final product.
Comparative example 1
3% nimbin transmits preparation: with embodiment 1, jervine is not added.
Comparative example 2
3% jervine transmits preparation with embodiment 3, and nimbin is not added.
Test example 1
The screening of carrier phospholipid species: it is screened using encapsulation rate and drugloading rate as index, as a result see the table below.
It is seen by result, the equal highest of encapsulation rate and drugloading rate of soybean lecithin, so selection soybean lecithin.
Test example 2
Carrier phosphatide and cholesterol ratio screen: using encapsulation rate and drugloading rate as index, as a result see the table below.
It is seen by result, phosphatide and the encapsulation rate and the equal highest of drugloading rate when cholesterol ratio 1:2, so selection soybean lecithin
With cholesterol ratio 1:2.
Test example 3
Mealybug insecticidal test
(1) 600 long tailed mealybugs, 510 Nan Yang stern line mealybugs, 522 short-tube lycoris silk floss mealybugs are randomly divided into 6 groups respectively, respectively
For 1,2,3 group of embodiment, control group (40% chlorpyrifos ec), 1,2 group of comparative example, it is respectively charged into the consistent plastics of size
In box.
(2) usage and dosage
Embodiment 1,2,3: 100 times of dilution is tested every group of dosage 20ml, is uniformly sprayed in the plastic casing of mealybug worm.Daily
Spray 1 time, continuous spray 3 days.
40% chlorpyrifos ec: 100 times of dilution tests every group of dosage 20ml, is uniformly sprayed at the plastic casing of mealybug worm
It is interior.Every spray 1 time, continuous spray 3 days.
Comparative example 1,2: 100 times of dilution is tested every group of dosage 20ml, is uniformly sprayed in the plastic casing of mealybug worm.Often
Spray 1 time, continuous spray 3 days.
It is as follows to kill mealybug worm effect:
According to the experimental results, the embodiment of the present invention 2 is best to 3 kinds of mealybug insecticidal effects, mealybug worm killing rate 96% with
On, illustrate optimal to mealybug worm control efficiency in nimbin, jervine ratio 1:2.And it can see nimbin and jervine
Effect is used alone far away from compound preparation.
The preferred embodiment of the present invention has been described in detail above.It should be appreciated that those skilled in the art without
It needs creative work according to the present invention can conceive and makes many modifications and variations.Therefore, all technologies in the art
Personnel are available by logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea
Technical solution, all should be within the scope of protection determined by the claims.
Claims (9)
1. a kind of mealybug insecticide, which is characterized in that active constituent is made of nimbin and jervine, nimbin and jervine
Mass ratio be 1: 30-40: 1.
2. a kind of mealybug insecticide according to claim 1, which is characterized in that the suitable dosage form has emulsion, wettable powder
Agent, water dispersible granules, suspending agent, oil-suspending agent, ultra low volume liquids, electrostatic oil agent or dry suspending agent, carrier.
3. a kind of mealybug insecticide according to claim 1, which is characterized in that the dosage form is carrier.
4. a kind of mealybug insecticide according to claim 1, which is characterized in that the carrier prescription weight percent is calculated as:
Nimbin 1-10%, jervine 1-10%, lecithin 10-30%, soybean lecithin 20-69%.
5. a kind of mealybug insecticide according to claim 1, which is characterized in that the carrier prescription weight percent is calculated as:
Nimbin 2-10%, jervine 2-10%, lecithin 10-15%, soybean lecithin 30-56%.
6. a kind of mealybug insecticide according to claim 1, which is characterized in that the carrier prescription weight percent is calculated as:
Nimbin 3.2%, jervine 9.6%, lecithin 12.9%, soybean lecithin 48.5%.
7. a kind of mealybug insecticide according to claim 1, which is characterized in that the carrier prescription weight percent is calculated as:
Nimbin 9.6%, jervine 3.2%, lecithin 12.9%, soybean lecithin 48.5%.
8. a kind of mealybug insecticide according to claim 3, which is characterized in that carrier the preparation method comprises the following steps:
1) soybean lecithin, lecithin, cholesterol, nimbin and jervine are dissolved in ethyl alcohol；
2) decompression rotary evaporation removes solvent, and lipid is made to form uniform film in bottle wall, and the hydration containing sodium taurocholate is added and is situated between
Matter abundant aquation lipid 2h under 37 °C is ultrasonically treated under ice bath to obtain the final product.
9. a kind of Pesticidal combination containing nimbin and jervine according to any one of claims 1 to 8 is applied to prevention and treatment
Agricultural pests mealybug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910833888.XA CN110476997A (en) | 2019-09-05 | 2019-09-05 | A kind of mealybug insecticide |
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|---|---|---|---|
| CN201910833888.XA CN110476997A (en) | 2019-09-05 | 2019-09-05 | A kind of mealybug insecticide |
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| CN110476997A true CN110476997A (en) | 2019-11-22 |
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| CN201910833888.XA Pending CN110476997A (en) | 2019-09-05 | 2019-09-05 | A kind of mealybug insecticide |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111011373A (en) * | 2019-12-26 | 2020-04-17 | 安徽云中生态农业开发有限公司 | Composite pesticide for controlling broccoli |
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| US10159251B2 (en) * | 2016-07-01 | 2018-12-25 | Mclaughlin Gormley King Company | Mixtures of sabadilla alkaloids and azadirachtin and uses thereof |
| CN106689241A (en) * | 2016-11-17 | 2017-05-24 | 中国热带农业科学院农产品加工研究所 | Pectin coated galangal essential oil lipidosome and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111011373A (en) * | 2019-12-26 | 2020-04-17 | 安徽云中生态农业开发有限公司 | Composite pesticide for controlling broccoli |
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Application publication date: 20191122 |