CN110475558A - 糖皮质激素受体调节剂在儿茶酚胺分泌型肿瘤治疗中的应用 - Google Patents

糖皮质激素受体调节剂在儿茶酚胺分泌型肿瘤治疗中的应用 Download PDF

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Publication number
CN110475558A
CN110475558A CN201880015928.3A CN201880015928A CN110475558A CN 110475558 A CN110475558 A CN 110475558A CN 201880015928 A CN201880015928 A CN 201880015928A CN 110475558 A CN110475558 A CN 110475558A
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CN
China
Prior art keywords
patient
glucocorticoid receptor
catecholamine
gra
treatment
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Pending
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CN201880015928.3A
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English (en)
Chinese (zh)
Inventor
A·G·莫来提斯
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Corcept Therapeutics Inc
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Corcept Therapeutics Inc
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Publication of CN110475558A publication Critical patent/CN110475558A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
CN201880015928.3A 2017-03-09 2018-03-08 糖皮质激素受体调节剂在儿茶酚胺分泌型肿瘤治疗中的应用 Pending CN110475558A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762469296P 2017-03-09 2017-03-09
US62/469,296 2017-03-09
PCT/US2018/021592 WO2018165460A1 (en) 2017-03-09 2018-03-08 Use of glucocorticoid receptor modulators in the treatment of catecholamine-secreting tumors

Publications (1)

Publication Number Publication Date
CN110475558A true CN110475558A (zh) 2019-11-19

Family

ID=63446773

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880015928.3A Pending CN110475558A (zh) 2017-03-09 2018-03-08 糖皮质激素受体调节剂在儿茶酚胺分泌型肿瘤治疗中的应用

Country Status (8)

Country Link
US (1) US11045482B2 (enExample)
EP (1) EP3592358A4 (enExample)
JP (3) JP7564620B2 (enExample)
CN (1) CN110475558A (enExample)
AU (1) AU2018230429B2 (enExample)
CA (1) CA3053806A1 (enExample)
MX (1) MX2019010732A (enExample)
WO (1) WO2018165460A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020132171A1 (en) * 2018-12-20 2020-06-25 Corcept Therapeutics Incorporated Methods for imaging and treatment of somatostatin-receptor positive tumors
JP2021079146A (ja) * 2021-02-22 2021-05-27 株式会社三洋物産 遊技機
JP7315071B2 (ja) * 2021-03-03 2023-07-26 株式会社三洋物産 遊技機

Citations (2)

* Cited by examiner, † Cited by third party
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TW201141522A (en) * 2010-02-05 2011-12-01 Phosphagenics Ltd Carrier composition
US20160310507A1 (en) * 2015-04-21 2016-10-27 Corcept Therapeutics, Inc. Optimizing mifepristone levels for cushing's patents

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GB9606736D0 (en) 1996-02-19 1996-06-05 Shire International Licensing Therapeutic method
CA2246791A1 (en) 1998-09-01 2000-03-01 Alison Buchan Treatment of endothelium with somatostatin analogues
US6818739B2 (en) 1999-12-03 2004-11-16 Ndsu Research Foundation Somatostatins
US6139845A (en) 1999-12-07 2000-10-31 Allergan Sales, Inc. Method for treating cancer with a neurotoxin
CN1556709A (zh) * 2001-03-23 2004-12-22 �Ƹ��� 使用糖皮质激素受体特效拮抗剂治疗压力症的方法
WO2003057214A1 (en) 2001-12-28 2003-07-17 Somatocor Pharmaceuticals, Inc. Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands
ATE407934T1 (de) 2004-03-09 2008-09-15 Corcept Therapeutics Inc Azadecalinverbindungen mit kondensiertem ring als glucocorticoidrezeptormodulatoren
GB0428151D0 (en) * 2004-12-22 2005-01-26 Novartis Ag Organic compounds
EP2145186A4 (en) * 2007-05-15 2010-10-20 Water Technologies Corp APPARATUS AND METHODS FOR DETECTION OF PLASMA METANEPHRINS
ES2626131T3 (es) 2007-10-17 2017-07-24 Laboratoire Hra Pharma Antagonistas del receptor de glucocorticoides tales como mifepristona para tratar el síndrome de Cushing
ES2351569B8 (es) 2009-05-07 2012-06-20 Bcn Peptides S.A. Ligandos peptídicos de receptores de somatostatina.
EP2429529B1 (en) 2009-05-12 2015-01-14 Corcept Therapeutics, Inc. Solid forms and process for preparing
KR101925955B1 (ko) 2011-03-18 2018-12-06 코어셉트 쎄라퓨틱스, 잉크. 피리미딘 사이클로헥실 글루코코르티코이드 수용체 조절제
WO2013039916A1 (en) * 2011-09-12 2013-03-21 The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Compositions for and methods of treatment and enhanced detection of non-pituitary tumors
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
RU2674983C1 (ru) 2013-11-25 2018-12-14 Корсепт Терапеутикс, Инк. Октагидро конденсированные азадекалиновые модуляторы глюкокортикоидного рецептора
CA2977591C (en) * 2015-03-02 2024-09-10 Corcept Therapeutics Inc Use of glucocorticoid receptor antagonist and somatostatin analogues to treat acth-secreting tumors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201141522A (en) * 2010-02-05 2011-12-01 Phosphagenics Ltd Carrier composition
US20160310507A1 (en) * 2015-04-21 2016-10-27 Corcept Therapeutics, Inc. Optimizing mifepristone levels for cushing's patents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
F W REUTTER ET AL.: ""Importance of detecting rapid changes in blood catechol amine levels in the diagnosis of pheochromocytoma", 《THE NEW ENGLAND JOURNAL OF MEDICINE》 *
张丽结等: "胰岛素、地塞米松和米非司酮对PC12细胞合成和分泌儿茶酚胺的影响及机制探究", 《药学进展》 *
郭妮妮等: "米非司酮对胰岛素抵抗大鼠儿茶酚胺含量的影响及可能机制", 《江苏医药》 *

Also Published As

Publication number Publication date
JP2024074854A (ja) 2024-05-31
MX2019010732A (es) 2019-11-01
WO2018165460A1 (en) 2018-09-13
AU2018230429B2 (en) 2023-06-15
JP2022090003A (ja) 2022-06-16
EP3592358A1 (en) 2020-01-15
JP2020510011A (ja) 2020-04-02
US20180256604A1 (en) 2018-09-13
CA3053806A1 (en) 2018-09-13
EP3592358A4 (en) 2020-12-16
US11045482B2 (en) 2021-06-29
JP7564620B2 (ja) 2024-10-09
AU2018230429A1 (en) 2019-09-05

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