CN110464691A - A kind of peach gum composition and its application - Google Patents
A kind of peach gum composition and its application Download PDFInfo
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- CN110464691A CN110464691A CN201810443410.1A CN201810443410A CN110464691A CN 110464691 A CN110464691 A CN 110464691A CN 201810443410 A CN201810443410 A CN 201810443410A CN 110464691 A CN110464691 A CN 110464691A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention discloses a kind of peach gum composition, the component including following parts by weight: 30-45 parts of peach gum, 2-4 parts of dendrobium candidum, 0.5-1 parts of tremella, 0.5-1 parts of Herba Cistanches, 5-8 parts of Anjidew NL50,7-10 parts and glycerol 35-45 parts of trehalose.The present invention is based on Chinese medicine Overall View, by the efficient compatibility, synergy such as peach gum and tremella, Herba Cistanches, dendrobium nobile.Peach gum composition of the invention has good timely moisture-keeping efficacy, while having significant anti-oxidant, improvement skin roughness, antiphlogistic effects, soft and fine smooth using rear skin.The composition has good film forming characteristics, lubrication, pro-skin simultaneously, and the raw material that can be used as skin care item is used, be can be widely applied in the skin care item of a variety of dosage forms, such as lotion, cream, surfactant, gel.The preparation method simple process of peach gum composition of the present invention, cost is relatively low, extraction efficiency is high, Product Safety is good.
Description
Technical field
The present invention relates to a kind of peach gum composition and its application and peach gum composition the answering in terms of preparing skin care item
With.
Background technique
Peach gum also known as peach oil, peach rouge, peach blossom tear, peach is solidifying, peach gum, is the natural of the dry upper outflow of rosaceous plant peach
The granular solids of resin, generally pale yellow viscous liquid or light yellow clear, thick liquid experience all sorts of the evaporation of solarization moisture i.e.
At granular solids, matter is hard, spar shape, outer likeness in form amber, and main group becomes galactolipin, rhamnose and phlorose aldehydic acid etc.,
Containing carbon water chemistry object, fat, protein and plant collagen, by peach naturally secret, or wound is generated under external force
Mouthful and secrete, peach gum is conducive to wound self-healing, summer and autumn harvesting, dries, and peach gum has water solubility and viscosity, for preparing water solubility
Adhesive, it is also possible to make thickener, emulsifier, there is cleaning blood and reducing fat, the effect of relieving stress with crease-resistant tender skin, be applied to food
The fields such as product, medicine, chemical industry.
Dendrobium candidum, tool fluid infusion are promoted the production of body fluid effect, have the title of " medicine circle giant panda " in medicinal plant circle." Taoist Scriptures " is by dendrobium nobile position
It occupies first of " Chinese nine big mesonas "；Shennong's Herbal claims dendrobium candidum to have " macrobiosis of making light of one's life by commiting suicide " effect.Modern scientific research table
Bright, dendrobium candidum can effectively improve epidermis rich in multiple nutritional components such as dendrobium polysaccharide, alkaloid, amino acid, vitamins
The expression of cell aquaporin AQP3, fluid infusion are promoted the production of body fluid.
Tremella, tonic medicine, the 60%~70% of Zhan Yiner dry weight, the main active of tremella is that tremella polysaccharides have pole
High medical value is the rare traditional Chinese medicine of Chinese tradition.Tremella polysaccharides have moisturizing and oxidation resistant activity, are a kind of excellent
Cosmetic additive agent.In addition, tremella is also rich in natural characteristic colloid, long-time service has good moisturizing effect.
Herba Cistanches are known as the good reputation of " desert ginseng ", are a kind of parasitic plants for colonizing in desert trees sacsaoul root, tool
Have and moisten oiliness stagnant, there is the laudatory title of " hat in bacterium ".Modern scientific research shows that Herba Cistanches are just made by Western Regions various countries in history
For one of highest help drug of usage frequency in the treasure and ancient prescription of Shang Gong imperial court.
The main active polysaccharide of peach gum is water soluble ingredient, and the prior art is mostly used when preparing peach gum extracting solution
Organic solvent such as ethyl alcohol etc. extracts, and this method recovery rate is low, and extractive with organic solvent is applied in skin care item
There are safety issues.In addition, the alkali carries method that the prior art uses, polysaccharide yield causes product electric instead without significantly improving
Conductance increases, and preparation process need to constantly regulate and control pH, and applied to needing complicated lixiviating before skin care item, go sour processing, process is many and diverse,
It is unsuitable for industrialized production.Meanwhile after peach gum crushes, raw material is relatively viscous, is unfavorable for producing, and for expanding production, needs to simplify behaviour
Make.In addition, the compounding of peach gum and other plant raw material, synergistic aspect study it is less.
Summary of the invention
It is an object of the invention to according to problem of the existing technology, provide a kind of peach gum composition and its application.
The present invention is based on Chinese medicine Overall View, by the efficient compatibility, synergy such as peach gum and tremella, Herba Cistanches, dendrobium nobile.Of the invention
Peach gum composition has good timely moisture-keeping efficacy, while having significant anti-oxidant, improvement skin roughness, anti-inflammatory effect
Fruit, it is soft and fine smooth using rear skin.The composition has good film forming characteristics simultaneously, and lubrication, pro-skin can be used as skin care item
Raw material uses, and can be widely applied in the skin care item of a variety of dosage forms, such as lotion, cream, surfactant, gel.Peach gum of the present invention
The preparation method simple process of composition, cost is relatively low, extraction efficiency is high, Product Safety is good.
According to an aspect of the invention, there is provided a kind of peach gum composition, the component including following parts by weight: peach gum
30-45 parts, 2-4 parts of dendrobium candidum, 0.5-1 parts of tremella, 0.5-1 parts of Herba Cistanches, 5-8 parts of Anjidew NL50,7-10 parts of trehalose and glycerol
35-45 parts.
According to certain embodiments of the present invention, the parts by weight of the peach gum extracting solution are 33-40 parts, preferably 35-
38 parts, more preferably 36-37 parts.
The preparation method of preferred embodiment in accordance with the present invention, the peach gum extracting solution includes:
A1 peach gum raw material is mixed with water), obtains peach gum mixed liquor；
A2 the peach gum mixed liquor) is heated to 60-90 DEG C, keeps 1-3h；
A3 processing) is filtered to the mixed liquor of step A2), filtrate is peach gum extracting solution.
According to some embodiments of the present invention, the step A1) in the weight ratio of peach gum raw material and water be 1:5-50, preferably
For 1:10-45, more preferably 1:15-40, further preferably 1:20-35.
The present inventor is the study found that during preparing peach gum extracting solution, and the solid-liquid ratio of peach gum and water is to extraction effect
It is most important, if the dosage of water is excessive, the waste of water resource is caused, reduces recovery rate；If the dosage of water is very few, activity at
Dividing cannot be fully dissolved out, and recovery rate is low.Solid-liquid ratio of the invention is selected to can get preferable extraction efficiency and polysaccharide yield.
According to one embodiment of present invention, the preparation method of the peach gum extracting solution further include: step A11) to described
Peach gum mixed liquor carries out swelling treatment.
In some specific embodiments, the time of the preferably described swelling treatment is 0.5-4h, more preferably 1-3h, into one
Step is preferably 1-2.5h, is even more preferably 2h.
For the present inventor the study found that during preparing peach gum extracting solution, carrying out swelling treatment to peach gum mixed liquor can
Obtain preferable extraction efficiency and polysaccharide yield, this is because allow hydrone to enter inside colloid by swelling, using hydrogen bond and
Van der Waals force promotes it to be in rarefaction, and at the extraction, active constituent is easier to extract.
In addition, swelling time is equally particularly significant for extraction efficiency, swelling time is too long equally to bring above-mentioned polysaccharide
Loss and anti-corrosion burden.Meanwhile the selection of swelling temperature is extremely important for the energy consumption reduction of industrialized production, of the invention
Under process conditions, the inventors discovered that swelling temperature raising is unobvious for the raising effect of polysaccharide extract rate, therefore using normal
Advise swelling temperature.
According to the preferred embodiment of the present invention, step A2) in the peach gum mixed liquor is heated to 65-84 DEG C, preferably
70-83 DEG C, more preferable 72-82 DEG C, further preferred 75-80 DEG C.
According to the preferred embodiment of the present invention, step A2) in by the peach gum mixed liquor heating after, keep 1-2.5h,
It is preferred that 1.3-2h, more preferable 2h.
The present inventor is the study found that during preparing peach gum extracting solution, and the temperature and time of extraction is to extraction effect
Most important, Extracting temperature is too low or the time is too short, then extraction efficiency is low, and active constituent cannot be fully dissolved out；Extracting temperature
Excessively high or overlong time then expends resource, improves production cost, also results in active constituent denaturation.Extraction time is too long, special
It is not to stay overnight processing, cooperating microorganisms is easier under damp and hot weather, it, can also be to anti-in addition to loss polysaccharide, reducing polysaccharide yield
Corruption brings burden.
The temperature and time for selecting swelling and extraction of the invention, can get preferable extraction efficiency and polysaccharide yield, In
There is realistic meaning in terms of reducing production cost in industrialized production.
According to certain embodiments of the present invention, the parts by weight of the dendrobium candidum are 2.5-3.5 parts, preferably 2.8-
3.2 parts, more preferably 3 parts.
Preferred embodiment in accordance with the present invention, the dendrobium candidum include dendrobium candidum stem extracting solution.
In some specific embodiments, the dendrobium candidum stem extracting solution is prepared via a method which: will be smashed
Dendrobium candidum stem raw material is uniformly mixed with water, obtains dendrobium candidum stem extracting solution.
According to certain embodiments of the present invention, the dendrobium candidum stem raw material is crushed to 80-100 mesh.
According to the preferred embodiment of the present invention, the weight ratio of the dendrobium candidum stem raw material and water is 1:150-200, excellent
Select 1:180-190, more preferably 1:185.
According to some embodiments of the present invention, the parts by weight of the tremella be 0.7-0.9 parts, preferably 0.75-0.85 parts,
More preferably 0.8 part.
Preferred embodiment in accordance with the present invention, the tremella include Tremella fructification extracting solution.
In some specific embodiments, the Tremella fructification extracting solution is prepared via a method which: will be smashed
Tremella fructification raw material is uniformly mixed with water, obtains Tremella fructification extracting solution.
According to certain embodiments of the present invention, the Tremella fructification raw material is crushed to 40-60 mesh.
According to the preferred embodiment of the present invention, the weight ratio of the Tremella fructification raw material and water is 1:150-200, excellent
Select 1:180-190, more preferably 1:185.
According to some embodiments of the present invention, the parts by weight of the Herba Cistanches are 0.7-0.9 parts, preferably 0.75-0.85
Part, more preferably 0.8 part.
Preferred embodiment in accordance with the present invention, the Herba Cistanches include Herba Cistanches extracting solution.
In some specific embodiments, the Herba Cistanches extracting solution is prepared via a method which: by smashed meat desert
Rong's raw material is uniformly mixed with water, obtains Herba Cistanches extracting solution.
According to certain embodiments of the present invention, the Herba Cistanches raw material is crushed to 40-60 mesh.
According to the preferred embodiment of the present invention, the weight ratio of the Herba Cistanches raw material and water be 1:150-200, preferably 1:
180-190, more preferably 1:185.
According to certain embodiments of the present invention, the parts by weight of the trehalose are 8-9 parts, preferably 8.5 parts.
The addition of trehalose can be reduced anti-corrosion dosage, be reduced the irritation of product with stabilising system.
According to some embodiments of the present invention, the parts by weight of the glycerol are 36-44 parts, preferably 37-43 parts, more excellent
38-42 parts are selected as, further preferably 39-41 parts, further preferably 40 parts.
The addition of glycerol, can be synergistic, supplements the intracorporal natural moisture preserving ingredient of people.
Some specific embodiments according to the present invention, the parts by weight of the water are 32-38 parts, preferably 33-36 parts, more excellent
It is selected as 35 parts.
According to another aspect of the present invention, the application of above-mentioned peach gum composition, peach gum composition of the invention are provided
It can be applied in the skin care item of a variety of dosage forms, such as lotion, cream, surfactant, gel.
Peach gum composition of the invention is used to prepare skin care item as additive by preferred embodiment in accordance with the present invention,
The skin care item may include the component of following parts by weight: 3-8 parts of peach gum composition, 0.5-2 parts of thickener, is prevented 1-3 parts of transdermal enhancer
Rotten agent 0.1-0.5 parts, 85-95 parts of water.
According to certain embodiments of the present invention, the parts by weight of the peach gum composition are 4-7 parts, preferably 5-6 parts.
According to the preferred embodiment of the present invention, the parts by weight of the transdermal enhancer are 1.5-2.5 parts, preferably 2 parts.
In some specific embodiments, the transdermal enhancer includes urea, 1,2- pentanediol and 1, in 3- hexylene glycol extremely
Few one kind.
Preferred embodiment in accordance with the present invention, the parts by weight of the thickener are 0.8-1.5 parts, preferably 1 part.
In some specific embodiments, the thickener include xanthan gum, AVC, gellan gum, TR-1, sodium alginate and
At least one of ammonium acryloyl taurate/VP copolymer.
According to some embodiments of the present invention, the parts by weight of the preservative are 0.11-0.3 parts, preferably 0.12-
0.2 part.
In some specific embodiments, the preservative includes Phenoxyethanol, Chlorphenesin, methylparaben and methyl
At least one of isothiazolinone/iodine propilolic alcohol butyl mephenesin Carbamate.
According to the preferred embodiment of the present invention, the skin care item are prepared via a method which:
1) 70-90 DEG C is heated to after mixing raw water and transdermal enhancer；
2) stirring cooling, is added thickener at 50-70 DEG C；
3) peach gum composition, preservative are added at 40-42 DEG C for stirring cooling；
4) stirring cooling, 38 DEG C with bottom discharge.
It is preferably described to be added to the skin care item of peach gum composition by the following method in some specific embodiments:
1) 80 DEG C will be heated to after raw water and transdermal enhancer；
2) stirring cooling, is added thickener at 60 DEG C；
3) peach gum composition, preservative are added at 40 DEG C for stirring cooling；
4) stirring cooling, 38 DEG C with bottom discharge.
The above method of the invention can protect the bioactivity of natural plant polyose to the greatest extent, avoid polysaccharide component
Heated coking, cracking and oxidation.Meanwhile production process energy consumption can be largely reduced.
Advantages of the present invention and advantageous effects include:
1, the present invention prepares peach gum extracting solution using special method, does not use organic solvent, method handy and safe, and mention
Take high-efficient, the polyoses content height in peach gum extracting solution.
2, peach gum composition of the invention is synergistic, has good moisture-keeping efficacy, skin glossiness can be improved, and moistens
Damp skin, while there is good film forming characteristics, lubrication, pro-skin, the raw material that can be used as skin care item use.
3, preparation process is simple, more favorably uses industrialized production.
Specific embodiment
Combined with specific embodiments below, the present invention is described in further details:
Peach gum used in following embodiments is purchased from the county Ju Heng Yuanxiang commerce and trade Co., Ltd, light yellow to red, in crystallization
Stone shape, hard, color is bright；Dendrobium candidum has purchased from Pu'er Da Run iron growing dendrobium Co., Ltd in the section of oblate cylindricality
Deep longitudinal furrow or vertical rib, the section for the visible sepia having, section yellow-white to yellowish-brown have most tendon and vessel points being dispersed in, surface gold
Yellow, green-yellow or brown color have a small amount of purple microgroove；Herba Cistanches hold brightness medicine company sale Co., Ltd purchased from the city Hao Zhou, are in
Oblate cylindricality, slightly bent, surface sepia or taupe brown to black, the close fleshy scale leaf arranged by imbricate, section sepia,
Weight, matter is hard, slightly flexible, is not easily broken；Tremella is in nature closely circle shape purchased from the careless prepared slices of Chinese crude drugs Co., Ltd of Beijing thousand,
Auricle is loose, has a little ear base, auricle is translucent light yellow glossy.
The measurement of the polysaccharide content method of peach gum extracting solution of the present invention is as described below:
Phend-sulphuric acid: ethyl alcohol, which extracts, removes the interference components such as monosaccharide, oligosaccharide, glycoside and alkaloid, is then mentioned with water
Take the polysaccharide component contained by it.Polysaccharide is hydrolyzed into monosaccharide under concentrated sulfuric acid effect, and rapid dehydration generates uronic acid derivative
Object measures its polyoses content with spectrophotometry with phenol condensation at orange compound.
Specific test method:
Titer preparation: it weighs through 105 DEG C of dry DEXTROSE ANHYDROUS 55.0mg to constant weight, with deionized water dissolving constant volume
In 100mL volumetric flask, obtaining concentration is 0.550mg/mL glucose stock liquid, spare.It is 0.0880mg/ that dilution, which is settled to concentration,
ML glucose standards solution.
Test fluid: pipetting a certain amount of fluid sample, in 100mL conical flask, is added 95% ethyl alcohol of 9 times of volumes, and 4
12h is stood at DEG C, is centrifuged 30min in 5000r/min, is discarded supernatant liquid, after centrifugation, pass through suction pipe 95% ethanol rinse of 3mL
It is centrifuged tube wall, washing lotion is removed with suction pipe, washs 3 times, with removal centrifugation tube wall and the remaining monosaccharide of precipitation surface.Sediment is used
(60 ± 2) DEG C hot water sufficiently dissolves, and three times with (60 ± 2) DEG C hot water washing centrifuge tube, merges sediment lysate and washing
Liquid pours into 50mL or 100mL volumetric flask, and it is spare to scale to let cool rear constant volume.
According to the difference of polyoses content in sample, usually need to carry out suitable multiple to sample polysaccharide extraction liquid before the assay
Dilution, the determination of extension rate answer so that in cuvette the light absorption value of test fluid in the range of working curve is covered, and
It is located in the middle part of standard curve as far as possible.
It takes sample polysaccharide extraction liquid or its dilution 2.000mL to be put into test tube, blank pair is done with 2.000mL deionized water
According to, be separately added into phenol liquid 1.000mL, with pipette be added the 5.00mL concentrated sulfuric acid, whirlpool mix after place 5min, tube sealing boiling water
Bathe 15min, be cooled to room temperature, reference measurement absorbance is done with blank test solution at 490nm, every kind of sample do 3 groups it is parallel.
Free radical scavenging activity measurement is carried out to peach gum extracting solution as follows:
Aging is a complicated process, and wherein free radical theory is exactly generally acknowledged one of anti-aging theory.And it removes
ABTS free radical is a kind of usual manner for analyzing antioxidant.Indicate that tested material removes the energy of free radical with clearance rate in test
Power, clearance rate are bigger, then it represents that its oxidation resistance is stronger.
Specific test method:
It takes 0.0192gABTS that 5.00mL deionized water dissolving is added, mixes, be prepared into 7mmolL-1ABTS stock solution.
0.1892g potassium peroxydisulfate is weighed, 5.000mL deionized water dissolving is added, mixes, is prepared into 140mmolL-1Stock solution.It will
A certain amount of 7mmolL-1ABTS and 140mmolL-1Potassium peroxydisulfate mixing, be protected from light lower standings for a period of time in room temperature
Afterwards, ABTS free radical stock solution is formed.A certain amount of ABTS free radical stock solution is taken, is diluted with 50% ethyl alcohol, makes final test
Negative control light absorption value is 0.70 ± 0.02.
Tested peach gum extracting solution is diluted to the test fluid that concentration is 1.0% with 50% ethyl alcohol.Certainly by test fluid, ABTS
It is sequentially added by base stock solution, is vortexed and mixes, be placed in microplate reader and be protected from light incubation, at interval of 20min, with microplate reader in wavelength
Its light absorption value is measured at 734nm.ABTS free radical scavenging activity is calculated by formula (1).
In formula (1): A is OD value after test fluid is mixed with ABTS solution, and B is OD after 50% ethyl alcohol is mixed with ABTS solution
Value, C are OD value after 50% ethyl alcohol is mixed with sample solution.
Embodiment 1-9
1) 10g peach gum is added in 50-500ml water, the weight ratio of peach gum and water is 1:5-50, obtains peach gum mixed liquor；
2) the peach gum mixed liquor is heated to 60-90 DEG C, 1-3h is kept to extract；
3) processing is filtered to the mixed liquor that step 2) obtains, filtrate is peach gum extracting solution.
Determination step 3) made from polyoses content and its clearance rate to ABTS free radical in peach gum extracting solution, data
With the results are shown in Table 1.
Embodiment 10
1) peach gum is crushed to 40 mesh, obtains smashed peach gum raw material；
2) the smashed peach gum of 10g is added in 200ml water, the weight ratio of peach gum and water is 1:20, obtains peach gum mixing
Liquid；
3) the peach gum mixed liquor is heated to 80 DEG C, 2h is kept to extract；
4) processing is filtered to the mixed liquor that step 3) obtains, filtrate is peach gum extracting solution.
Determination step 4) made from polyoses content and its clearance rate to ABTS free radical in peach gum extracting solution, data
With the results are shown in Table 1.
Embodiment 11-15
1) 10g peach gum is added in 200ml water, the weight ratio of peach gum and water is 1:20, obtains peach gum mixed liquor；
2) peach gum mixed liquor is swollen 0.5-4h；
3) the peach gum mixed liquor after swelling is heated to 80 DEG C, 2h is kept to extract；
4) processing is filtered to the mixed liquor that step 3) obtains, filtrate is peach gum extracting solution.
Determination step 4) made from polyoses content and its clearance rate to ABTS free radical in peach gum extracting solution, data
With the results are shown in Table 1.
Embodiment 16
1) peach gum is crushed to 40 mesh, obtains smashed peach gum raw material；
2) the smashed peach gum of 10g is added in 200ml water, the weight ratio of peach gum and water is 1:20, obtains peach gum mixing
Liquid；
3) peach gum mixed liquor is swollen 2h；
4) the peach gum mixed liquor is heated to 80 DEG C, 2h is kept to extract；
5) processing is filtered to the mixed liquor that step 4) obtains, filtrate is peach gum extracting solution.
Determination step 5) made from polyoses content and its clearance rate to ABTS free radical in peach gum extracting solution, data
With the results are shown in Table 1.
The data and measurement result of each embodiment are shown in Table 1.
Comparative example 1-7
With embodiment 1, but peach gum is different from the weight ratio of water, Extracting temperature or extraction time, data and measurement result
It is shown in Table 1.
Comparative example 8
With embodiment 1, but with 40% ethanol water replacement step 1) in water, data and measurement result are shown in Table 1.
Comparative example 9
With embodiment 11, but with 40% ethanol water replacement step 1) in water, data and measurement result are shown in Table
1。
Table 1
By embodiment 1-4 compared with comparative example 1-2 it is found that when solid-liquid ratio is 1:5-50, the extraction of peach gum extracting solution
Excellent in efficiency, polysaccharide yield are high；After being more than this solid-liquid ratio, the dosage of water is excessive, can reduce recovery rate, polysaccharide yield drop instead
It is low, and will also result in the waste of water resource；When solid-liquid ratio is less than 5, extraction operation can not achieve in technique.In addition, by reality
After example 1 and embodiment 10 are applied it is found that crushing to peach gum, polysaccharide yield improves not significant；The present inventor has found under study for action,
After peach gum is crushed, it will lead to raw material and relatively glue, be unfavorable for producing, therefore in order to which expanding production, simplified operation, raising production are imitated
Rate, present invention preferably employs not pulverization process.Comparative example 8-9 is the method extracted using organic solvent, by embodiment 1 and is compared
Example 8-9 comparison it is found that using organic solvent extract method not only recovery rate is low, and by extractive with organic solvent be applied to shield
There are safety issues in skin product.As shown in Table 1, peach gum composition of the invention has the energy for preferably removing ABTS free radical
Power illustrates that it has good antioxidant activity in biochemistry level.
The measurement of hyaluronidase rejection ability is carried out to the peach gum extracting solution of embodiment 13 as follows:
Tested peach gum extracting solution is diluted to the sample that concentration is 0.15%, 0.5% with 50% ethyl alcohol, by table 2 to examination
CaCl is separately added into pipe2, hyaluronidase, sample, Sodium Hyaluronate, NaOH, Boratex, p-DMAB fully shake, in 30
DEG C 30min is prevented, be transferred in 96 orifice plates, light absorption value is surveyed at 582nm.Positive control is done with dipotassium glycyrrhizinate.
2 prepare liquid of table composition
Remarks: "+" is this addition, and "-" is that this is not added, but is replaced with hac buffer
Using surveyed absorbance value, inhibiting rate, antiallergic activity calculation formula are calculated are as follows:
In formula (2): A is by contrast solution OD value (replacing sample solution with hac buffer)；B is control blank solution OD
It is worth (replacing sample solution and enzyme solution with hac buffer)；C is sample solution OD value；D is that sample blank solution O D value (uses vinegar
Acid buffering solution replaces enzyme solution).
Various concentration sample and control group are as shown in Figure 1 to hyaluronic acid enzyme inhibition rate result.Hyaluronidase
(Hyaluronidase, HAase) is the hydrolase of hyaluronic acid (Hyaluronic acid, HA), the hair of it and inflammation, allergy
It is raw that there is close connections.HAase inhibitor can effectively adjust the equilibrium relation of HA-HAase, and rise to antiallergic corresponding
Effect.Therefore the relative amount of HA usually is improved by inhibiting HAase in cosmetics, and make it have antiallergic effect.In test
Inhibiting rate indicates sample to the rejection ability of hyaluronidase, and inhibiting rate is higher, and its antiallergic antiphlogistic effects of expression are better.It can by Fig. 1
Know, peach gum composition of the invention has the significant ability for inhibiting hyaluronidase, illustrates that it is anti-inflammatory with preferable antiallergic
Activity, acting on skin can releive skin inflammation damnification to a certain extent.
Embodiment 17
1) the 1g dendrobium candidum stem raw material for being crushed to 80-100 mesh is added in 180ml water, dendrobium candidum stem raw material and water
Weight ratio be 1:180, obtain dendrobium candidum stem extracting solution；
2) the Tremella fructification raw material that 1g is crushed to 40-60 mesh is added in 180ml water, Tremella fructification raw material and water
Weight ratio be 1:180, obtain Tremella fructification extracting solution；
3) the Herba Cistanches raw material that 1g is crushed to 40-60 mesh is added in 180ml water, the weight ratio of Herba Cistanches raw material and water
For 1:180, Herba Cistanches extracting solution is obtained.
Embodiment 18
Dendrobium candidum stem extracting solution prepared by peach gum extracting solution prepared by 40 parts of embodiments 13,3 parts of embodiments 17,1 part
Herba Cistanches extracting solution, 8 portions of trehaloses, 6 parts of PCA prepared by the Tremella fructification extracting solution of the preparation of embodiment 17,1 part of embodiment 17
Sodium is mixed with 40 parts of glycerol, is stirred evenly, and peach gum composition is obtained.
Embodiment 19
1) the 1 of 2 parts, 2- pentanediol is mixed with 91.88 parts of water, is heated to 80 DEG C and obtains alcoholic solution；
2) cooling is stirred to the alcoholic solution of step 1), 1 part of ammonium acryloyldime-thyltaurate/VP copolymerization is added at 60 DEG C
Object；
3) cooling is stirred to the solution of step 2), be added at 40 DEG C 5 parts of embodiments 18 peach gum composition and 0.12 part
Methylisothiazolinone/iodine propilolic alcohol butyl mephenesin Carbamate；
4) cooling is stirred to the solution of step 3), discharged at 38 DEG C, moisture-retention gel is made.
Comparative example 10
18 portions of trehaloses are mixed with 40 parts of glycerol, stirs evenly, obtains composition.
Comparative example 11
With embodiment 19, the peach of the preparation of composition alternative embodiment 18 only prepared in step 3) using comparative example 10
Moisture-retention gel is prepared in glue composition.
Comparative example 12
With embodiment 19, it is only added without the peach gum composition of the preparation of embodiment 18 in step 3), moisturizing is prepared
Gel.
Moisture-retention gel prepared by embodiment 19 and comparative example 11-12 is applied in human skin surface respectively, according to as follows
Method is measured skin moisture content, skin roughness, the scales of skin that peel off and smoothness.
Human body moisturizing test
It is divided into 3 groups, every group 15 at health volunteer 45 of 20~45 years old through professional's trained age before test
People.For all subjects without skin or systemic disease history, recipient site is without exception, and tested period does not smear any and experiment
Unrelated drug or cosmetics.
Test site room temperature (25 ± 1) DEG C, relative humidity (40 ± 5) %, subject should keep body to stablize before testing
State.After wiping subject's both arms using 35 DEG C or so of clear water, start to test after testing under environment the 30min that sits quietly.
At subject's inboard arm is away from palm base portion 5cm, mark tested region (4cm × 4cm), same arm can be simultaneously
Mark multiple regions (interval 1cm), test specimens random distribution.The blank value of each test zone is first measured, then press (2.0 ±
0.1)mg/cm2Dosage difference single application embodiment 19, comparative example 11,12 moisture-retention gel, after coating use multifunctional leather
Skin moisture tester measures the skin hydration state value in the tested region 1h, 2h, 4h and blank control region respectively.
Subject is smeared 5 data measured in same sample region and is averaged by test, using SPSS statistical software
Carry out t check analysis.
By before test use, using the moisture content change of skin after 1h, 2h, 4h, it is instant to skin is improved to evaluate
Moisture-keeping efficacy, as a result as shown in Figure 2.
In Fig. 2, each time point respectively indicates the moisturizing of coating comparative example 12, comparative example 11 and embodiment 19 from left to right
The skin moisture content change rate of gel.
Moisture content change rate (%)=(the rear preceding moisture content of moisture content-use of use)/preceding moisture content of use ×
100%.
As seen from Figure 2, relative to comparative example 11 and comparative example 12, the guarantor for being added to peach gum composition of the present invention is used
After wet gel can conspicuousness promoted skin moisture content, moistening effect is good, and can long-time moisturizing.
The instant improvement of roughness
The same moisture content change of test method.Test equipment is VisioScan VC98 image analyzer, before test use,
Using the scales of skin that peel off index and smoothness of skin after 1h, 2h, 4h, as a result as shown in Figure 3,4.
In Fig. 3, each time point respectively indicates the moisturizing of coating comparative example 12, comparative example 11 and embodiment 19 from left to right
The scaling of skin index of gel.As seen from Figure 3, relative to comparative example 11 and comparative example 12, using being added to peach of the present invention
The moisture-retention gel of glue composition, scaling of skin index are lower.
In Fig. 4, each time point respectively indicates the moisturizing of coating comparative example 12, comparative example 11 and embodiment 19 from left to right
The skin surface smoothness change rate of gel, the numerical value of smoothness is smaller, illustrates that skin is more smooth, can illustrate to a certain extent
Skin is more smooth.
Smoothness change rate=(using the rear preceding smoothness of smoothness-use)/uses preceding smoothness × 100%.
As seen from Figure 4, relative to comparative example 11 and comparative example 12, the guarantor for being added to peach gum composition of the present invention is used
Wet gel, smoothness change rate is smaller, illustrates to use rear smoothness smaller, skin is more smooth.
It should be noted that embodiment described above for explaining only the invention, is not constituted to of the invention any
Limitation.By referring to exemplary embodiments, invention has been described, it should be appreciated that word used in it is descriptive
With explanatory vocabulary, rather than limited vocabulary.The present invention can be made within the scope of the claims by regulation
Modification, and the present invention is revised in without departing substantially from scope and spirit of the present invention.Although the present invention described in it relates to
And specific method, material and embodiment, it is not intended that the present invention is limited to particular case disclosed in it, on the contrary, this hair
It is bright to can be extended to other all methods and applications with the same function.
Claims (10)
1. a kind of peach gum composition, the component including following parts by weight: 30-45 parts of peach gum, 2-4 parts of dendrobium candidum, tremella 0.5-1
Part, 0.5-1 parts of Herba Cistanches, 5-8 parts of Anjidew NL50,7-10 parts and glycerol 35-45 parts of trehalose.
2. peach gum composition according to claim 1, which is characterized in that the parts by weight of the peach gum are 33-40 parts, excellent
It is selected as 35-38 parts；The peach gum includes peach gum extracting solution.
3. peach gum composition according to claim 1 or 2, which is characterized in that the peach gum extracting solution is by the following method
Preparation:
A1 peach gum raw material is mixed with water), obtains peach gum mixed liquor；Preferably, the weight ratio of the peach gum raw material and water is 1:
5-50, preferably 1:10-40, more preferably 1:20；
A2) by the peach gum mixed liquor be heated to 60-90 DEG C, preferably 70-85 DEG C, it is 75-80 DEG C more preferable, keep 1-3h, preferably
1-2.5h more preferable 2h；
A3 processing) is filtered to the mixed liquor of step A2), filtrate is peach gum extracting solution.
4. peach gum composition described in any one of -3 according to claim 1, which is characterized in that the system of the peach gum extracting solution
Preparation Method further include: step A11) swelling treatment is carried out to the peach gum mixed liquor；It is preferred that the time of the swelling treatment is
0.5-4h, more preferably 1-3h, further preferably 1-2.5h, further preferably 2h.
5. peach gum composition described in any one of -4 according to claim 1, which is characterized in that the weight of the dendrobium candidum
Number is 2.5-3.5 parts, and preferably 3 parts, the dendrobium candidum includes dendrobium candidum stem extracting solution；And/or the weight of the tremella
Measuring part is 0.7-0.9 parts, and preferably 0.8 part, the tremella includes Tremella fructification extracting solution；And/or the weight of the Herba Cistanches
Measuring part is 0.7-0.9 parts, and preferably 0.8 part, the Herba Cistanches include Herba Cistanches extracting solution.
6. peach gum composition described in any one of -5 according to claim 1, which is characterized in that the parts by weight of the Anjidew NL50
It is 6-7 parts, preferably 6.5 parts；And/or the parts by weight of the trehalose are 8-9 parts, preferably 8.5 parts；And/or the glycerol
Parts by weight be 38-42 parts, preferably 40 parts.
7. the application of peach gum composition described in a kind of any one of claim 1-6, preferably includes to combine the peach gum
Object is applied to prepare skin care item.
8. application according to claim 7, the skin care item include the component of following parts by weight: being appointed in claim 1-6
3-8 parts of peach gum composition, 1-3 parts of transdermal enhancer, 0.5-2 parts of thickener, 0.1-0.5 parts of preservative, water 85-95 described in meaning one
Part.
9. application according to claim 7 or 8, which is characterized in that the transdermal enhancer includes urea, 1,2- pentanediol and 1,
At least one of 3- hexylene glycol；And/or the thickener include including xanthan gum, AVC, gellan gum, TR-1, sodium alginate and
At least one of ammonium acryloyl taurate/VP copolymer；And/or the preservative includes that Phenoxyethanol, chlorobenzene are sweet
At least one of ether, methylparaben and methylisothiazolinone/iodine propilolic alcohol butyl mephenesin Carbamate；And/or the water is
Deionized water.
10. the application according to any one of claim 7-9, which is characterized in that the skin care item are by the following method
Preparation:
1) 70-90 DEG C is heated to after mixing raw water and transdermal enhancer；
2) stirring cooling, is added thickener at 50-70 DEG C；
3) peach gum composition, preservative are added at 40-42 DEG C for stirring cooling；
4) stirring cooling, 38 DEG C with bottom discharge.
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| CN113616546B (en) * | 2021-07-14 | 2024-02-02 | 上海加新生物科技有限公司 | Peach resin polysaccharide gum capable of brightening skin, application and extraction preparation method thereof |
| CN113750006A (en) * | 2021-08-27 | 2021-12-07 | 植然天成(北京)生物科技有限公司 | Salvia miltiorrhiza mud-shaped mask and preparation method and use method thereof |
| CN113750006B (en) * | 2021-08-27 | 2022-10-28 | 植然天成(北京)生物科技有限公司 | Salvia miltiorrhiza mud-shaped mask and preparation method and use method thereof |
| CN114392350A (en) * | 2022-01-25 | 2022-04-26 | 浙江瘦金体健康管理集团有限公司 | Hyaluronic acid oral liquid and preparation method thereof |
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