CN110448588A - A kind of Chinese medicinal granule spray drying process - Google Patents
A kind of Chinese medicinal granule spray drying process Download PDFInfo
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- CN110448588A CN110448588A CN201810425302.1A CN201810425302A CN110448588A CN 110448588 A CN110448588 A CN 110448588A CN 201810425302 A CN201810425302 A CN 201810425302A CN 110448588 A CN110448588 A CN 110448588A
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- Prior art keywords
- spray
- drying process
- cream powder
- spray drying
- dried
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The present invention relates to Chinese medicinal granule production technical fields, and in particular to a kind of improved Chinese medicinal granule drying process with atomizing.Using spray drying process of the invention, especially with specific auxiliary material, the dosage of auxiliary material in granule not only be can control in minimum zone, reduce the dose of patient, the wall sticking phenomenon in spray-drying process can also greatly be improved, the material loss in spray-drying process is reduced, industrialized production is very beneficial to.
Description
Technical field
The present invention relates to Chinese medicinal granule production technical fields, and in particular to a kind of improved Chinese medicinal granule is spraying
Drying means belongs to Chinese medicine production technical field.
Background technique
Chinese medicinal granule is made of the extracted concentration of single medicinal material medicine materical crude slice, for the particle of tcm clinical practice formula.
Claiming single medicinal material concentrated granule, trade name and civil address before domestic, there are also the decocting-free traditional Chinese medicinal slices, new medicine materical crude slice, purification drinks
Piece, beverage type medicine materical crude slice, scientific Chinese medicine etc..
Drying process is an important link in Chinese medicinal granule preparation, and the dry method of Chinese medical concrete has very much
Kind, such as vacuum drying, freeze-drying, fluidized bed drying, spray drying.Wherein, spray drying has drying time short, dry
Area is big, effective component destroys the advantages that few, is the method ideal for one kind of Chinese medicine liquid semi liquid state dry materials.
For Chinese medicinal granule during clinical use, the prescription of doctor is usually constructed with more than ten taste medicines, if in work
In skill design, rationally effective control, the auxiliary material total amount of prescription are not carried out to the auxiliary material amount per medicine simply and is increased by, finally can
Cause dose excessive, makes troubles to patient.For this purpose, Chinese medicinal granule is generally not added or adds auxiliary material less as far as possible, more than 600
In a kind, the kind that auxiliary material is not added accounts for about 2/3 or more, that is to say, that most of kind is straight using water extracting and developing, concentration
It connects spray drying to be made, has the characteristics that content of dispersion is high, dose is small.But Chinese medicine aqueous extract contains carbohydrate, lymphatic temperament, resinae
Equal ingredients, when spray drying, are easy viscous wall, and traditional Chinese medicinal granule is being spray-dried in order to prevent during production
Stage medicinal powder glues wall and influences to produce, and needs to be added a large amount of auxiliary material to overcome, although the method for this large amount of addition auxiliary materials solves
It has determined technological problems, but for Chinese medicinal granule, it is excessive to have will lead to auxiliary material additional amount, not only manufactured product does not reach
To the purpose of concentration, the dose of patient is allowed to greatly increase instead, does not meet the process design principle of Chinese medicinal granule.How
In commercial process, prevents from gluing wall in spray-drying stage medicinal powder, reduce the loss of material, improve dried cream powder yield
Meanwhile controlling the dosage of auxiliary material in proper range, it is a technical problem urgently to be resolved.
Summary of the invention
That it is an object of the invention to overcome the deficiencies of the prior art and provide a kind of supplementary product consumptions is few, can effectively prevent spraying
Wall sticking phenomenon in mist drying process effectively improves a kind of Chinese medical concrete Chinese medicine of dried cream powder yield in spray-drying process and matches
Square particle spray drying means.
To solve the above-mentioned problems, the technical scheme adopted by the invention is that:
A kind of Chinese medicinal granule spray drying process, the method comprises the following steps: the Chinese medical concrete after taking concentration,
2%~7% betadex is added, mixes, filtration, at 170 DEG C~185 DEG C of inlet air temperature, 80 DEG C~95 DEG C items of leaving air temp
It is spray-dried under part, collects dried cream powder.
Chinese medical concrete spray drying process as described above, the as a preferred method, wherein Chinese medicine after the concentration
Relative density 1.05 to 1.12 of the medicinal extract at 60 DEG C.
4%~5% times of his ring is added as a preferred method, and pastes for Chinese medical concrete spray drying process as described above
Essence.
Chinese medical concrete spray drying process as described above, the inlet air temperature is 175 DEG C as a preferred method,
Leaving air temp is 95 DEG C.
Chinese medical concrete spray drying process as described above, the filtration is 65~80 meshes as a preferred method,
Filtration.
Betadex is mainly used for the inclusion of volatile oil as common pharmaceutic adjuvant, and less as spray drying
Auxiliary material, but inventor is by research dry to Chinese medicine preparation particle spray for many years, during discovery is used as using betadex
The dry major auxiliary burden of medicine composition particle spray, only need to be added a small amount of betadex, can greatly improve spray-drying process
In viscous tower phenomenon, greatly improve the yield in granule spray-drying process.In the prior art a small amount of document report its
The dosage used is also 5% or more, and supplementary product consumption is excessive, not only influences the content of main ingredient in granule, increases clothes for patients
Dosage also will cause the unfavorable effects such as the cost increase in industrialized production.Therefore using times his ring of content of the present invention
Dextrin not only can control the dosage of auxiliary material in granule in minimum zone, reduce the dose of patient, can also greatly change
Wall sticking phenomenon in kind spray-drying process, reduces the material loss in spray-drying process, is very beneficial to industrialized production.
Specific embodiment
The present invention is described in further details below by embodiment, these embodiments are only used to illustrate the present invention, and
It does not limit the scope of the invention.
Embodiment 1
Pogostemon cablin medicinal extract after taking concentration, relative density are 1.05 (60 DEG C), and 2% betadex is then added, and are mixed,
Filtration, is spray-dried under the conditions of 175 DEG C of inlet air temperature, 85 DEG C of leaving air temp, atomizer rotating speed 50Hz, collects dry cream
Powder.
Be spray-dried situation: slightly viscous wall, dried cream powder mobility is general, collects a small amount of dried cream powder, and dried cream powder yield is
80.2%.
Embodiment 2
Pogostemon cablin medicinal extract after taking concentration, relative density are 1.05 (60 DEG C), and 4% betadex is then added, and are mixed,
Filtration, is spray-dried under the conditions of 175 DEG C of inlet air temperature, 85 DEG C of leaving air temp, atomizer rotating speed 50Hz, collects dry cream
Powder.
It is spray-dried situation: not gluing wall, dried cream powder good fluidity collects loose dried cream powder, and dried cream powder yield is
95.4%.
Embodiment 3
Pogostemon cablin medicinal extract after taking concentration, relative density are 1.05 (60 DEG C), and 5% betadex is then added, and are mixed,
Filtration, is spray-dried under the conditions of 175 DEG C of inlet air temperature, 85 DEG C of leaving air temp, atomizer rotating speed 50Hz, collects dry cream
Powder.
It is spray-dried situation: not gluing wall, dried cream powder good fluidity collects loose dried cream powder, and dried cream powder yield is
95.6%.
Embodiment 4
Pogostemon cablin medicinal extract after taking concentration, relative density are 1.05 (60 DEG C), and 7% betadex is then added, and are mixed,
Filtration, is spray-dried under the conditions of 175 DEG C of inlet air temperature, 85 DEG C of leaving air temp, atomizer rotating speed 50Hz, collects dry cream
Powder.
It is spray-dried situation: not gluing wall, dried cream powder good fluidity collects loose dried cream powder, and dried cream powder yield is
92.2%.
Embodiment 5
Radix glycyrrhizae preparata medicinal extract after taking concentration, relative density are 1.08 (60 DEG C), and 2% betadex is added, stirs evenly, filters
It crosses, is spray-dried under conditions of 170 DEG C of inlet air temperature, 95 DEG C of leaving air temp, atomizer rotating speed 50Hz, collect dried cream powder.
Be spray-dried situation: viscous wall is serious, dried cream powder poor fluidity, and dried cream powder yield is 38.5%.
Embodiment 6
Radix glycyrrhizae preparata medicinal extract after taking concentration, relative density are 1.08 (60 DEG C), and 4% betadex is added, stirs evenly, filters
It crosses, is spray-dried under conditions of 175 DEG C of inlet air temperature, 95 DEG C of leaving air temp, atomizer rotating speed 50Hz, collect dried cream powder.
It is spray-dried situation: not gluing wall, dried cream powder good fluidity collects loose dried cream powder, and dried cream powder yield is
89.2%.
Embodiment 7
Radix glycyrrhizae preparata medicinal extract after taking concentration, relative density are 1.08 (60 DEG C), and 5% betadex is added, stirs evenly, filters
It crosses, is spray-dried under conditions of 180 DEG C of inlet air temperature, 95 DEG C of leaving air temp, atomizer rotating speed 50Hz, collect dried cream powder.
It is spray-dried situation: not gluing wall, dried cream powder good fluidity collects loose dried cream powder, and dried cream powder yield is
93.7%.
Embodiment 8
Radix glycyrrhizae preparata medicinal extract after taking concentration, relative density are 1.08 (60 DEG C), and 7% betadex is added, stirs evenly, filters
It crosses, is spray-dried under conditions of 180 DEG C of inlet air temperature, 90 DEG C of leaving air temp, atomizer rotating speed 50Hz, collect dried cream powder.
It is spray-dried situation: not gluing wall, dried cream powder good fluidity collects loose dried cream powder, and dried cream powder yield is
90.3%.
Embodiment 9
Radix paeoniae rubra medicinal extract after taking concentration, relative density are 1.10 (60 DEG C), and 2% betadex is added, stirs evenly, filters,
It is spray-dried under conditions of 170 DEG C of inlet air temperature, 80 DEG C of leaving air temp, atomizer rotating speed 50Hz, collects dried cream powder.
Be spray-dried situation: viscous wall is serious, dried cream powder poor fluidity, and dried cream powder yield is 33.8%.
Embodiment 10
Radix paeoniae rubra medicinal extract after taking concentration, relative density are 1.10 (60 DEG C), and 4% betadex is added, stirs evenly, filters,
It is spray-dried under conditions of 170 DEG C of inlet air temperature, 80 DEG C of leaving air temp, atomizer rotating speed 50Hz, collects dried cream powder.
It is spray-dried situation: not gluing wall, dried cream powder good fluidity collects loose dried cream powder, and dried cream powder yield is
89.3%.
Embodiment 11
Radix paeoniae rubra medicinal extract after taking concentration, relative density are 1.10 (60 DEG C), and 5% betadex is added, stirs evenly, filters,
It is spray-dried under conditions of 170 DEG C of inlet air temperature, 80 DEG C of leaving air temp, atomizer rotating speed 50Hz, collects dried cream powder.
It is spray-dried situation: not gluing wall, dried cream powder good fluidity collects loose dried cream powder, and dried cream powder yield is
86.2%.
Embodiment 12
Radix paeoniae rubra medicinal extract after taking concentration, relative density are 1.10 (60 DEG C), and 7% betadex is added, stirs evenly, filters,
It is spray-dried under conditions of 170 DEG C of inlet air temperature, 80 DEG C of leaving air temp, atomizer rotating speed 50Hz, collects dried cream powder.
It is spray-dried situation: not gluing wall, dried cream powder good fluidity collects loose dried cream powder, and dried cream powder yield is
85.5%.
Claims (5)
1. a kind of Chinese medicinal granule spray drying process, which is characterized in that the method comprises the following steps: after taking concentration
2%~7% betadex is added in Chinese medical concrete, mixes, filtration, at 170 DEG C~185 DEG C of inlet air temperature, 80 DEG C of leaving air temp
It is spray-dried under the conditions of~95 DEG C, collects dried cream powder.
2. spray drying process according to claim 1, wherein the Chinese medical concrete after the concentration is in 60 DEG C of relative densities
1.05 to 1.12.
3. according to claim 1 or 2 described in any item spray drying process, wherein the Chinese medical concrete is added 4%~5%
Betadex.
4. spray drying process according to claim 1-3, wherein the filtration is that 65~80 meshes filter.
5. spray drying process according to claim 1-5, wherein the inlet air temperature in the spray drying is
175 DEG C, leaving air temp is 95 DEG C.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810425302.1A CN110448588A (en) | 2018-05-07 | 2018-05-07 | A kind of Chinese medicinal granule spray drying process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494458A (en) * | 2020-05-18 | 2020-08-07 | 广州市香雪制药股份有限公司 | Preparation method of patchouli formula granules |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494458A (en) * | 2020-05-18 | 2020-08-07 | 广州市香雪制药股份有限公司 | Preparation method of patchouli formula granules |
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- 2018-05-07 CN CN201810425302.1A patent/CN110448588A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494458A (en) * | 2020-05-18 | 2020-08-07 | 广州市香雪制药股份有限公司 | Preparation method of patchouli formula granules |
Non-Patent Citations (1)
| Title |
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| 余银芳等: "舒凉含片喷雾干燥工艺研究 ", 《江西中医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494458A (en) * | 2020-05-18 | 2020-08-07 | 广州市香雪制药股份有限公司 | Preparation method of patchouli formula granules |
| CN111494458B (en) * | 2020-05-18 | 2022-02-15 | 广州市香雪制药股份有限公司 | Preparation method of patchouli formula granules |
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Application publication date: 20191115 |