CN110448483A - Phase inversion emulsion and preparation method thereof - Google Patents
Phase inversion emulsion and preparation method thereof Download PDFInfo
- Publication number
- CN110448483A CN110448483A CN201910741719.3A CN201910741719A CN110448483A CN 110448483 A CN110448483 A CN 110448483A CN 201910741719 A CN201910741719 A CN 201910741719A CN 110448483 A CN110448483 A CN 110448483A
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- China
- Prior art keywords
- phase inversion
- inversion emulsification
- acid
- emulsification body
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004945 emulsification Methods 0.000 title claims description 63
- 238000002360 preparation method Methods 0.000 title description 9
- 239000000839 emulsion Substances 0.000 title description 2
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 44
- -1 fatty acid ester Chemical class 0.000 claims abstract description 37
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 32
- 239000000194 fatty acid Substances 0.000 claims abstract description 32
- 229930195729 fatty acid Natural products 0.000 claims abstract description 32
- 239000004584 polyacrylic acid Substances 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 43
- 239000003995 emulsifying agent Substances 0.000 claims description 19
- 229960001631 carbomer Drugs 0.000 claims description 18
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 150000002148 esters Chemical class 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- 230000008719 thickening Effects 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 9
- 239000003002 pH adjusting agent Substances 0.000 claims description 8
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 6
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 4
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 4
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 4
- 229920006037 cross link polymer Polymers 0.000 claims description 4
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 4
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 claims description 4
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 4
- 229940070765 laurate Drugs 0.000 claims description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 4
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 claims description 4
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 4
- 239000004475 Arginine Substances 0.000 claims description 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 3
- 241001506047 Tremella Species 0.000 claims description 3
- 241000908178 Tremella fuciformis Species 0.000 claims description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 claims description 3
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 3
- 229920001282 polysaccharide Polymers 0.000 claims description 3
- 239000005017 polysaccharide Substances 0.000 claims description 3
- BSLCSFCXSUCFQN-UHFFFAOYSA-N 1-aminobutane-2,3-diol Chemical compound CC(O)C(O)CN BSLCSFCXSUCFQN-UHFFFAOYSA-N 0.000 claims description 2
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 2
- 235000021357 Behenic acid Nutrition 0.000 claims description 2
- IUMSDRXLFWAGNT-UHFFFAOYSA-N Dodecamethylcyclohexasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 IUMSDRXLFWAGNT-UHFFFAOYSA-N 0.000 claims description 2
- 239000005639 Lauric acid Substances 0.000 claims description 2
- 229920000305 Nylon 6,10 Polymers 0.000 claims description 2
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims description 2
- 229940116226 behenic acid Drugs 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 229960000541 cetyl alcohol Drugs 0.000 claims description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 229960000735 docosanol Drugs 0.000 claims description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 2
- 238000003825 pressing Methods 0.000 claims description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 2
- 229960003415 propylparaben Drugs 0.000 claims description 2
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 2
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 2
- 229960000281 trometamol Drugs 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- 229960005323 phenoxyethanol Drugs 0.000 claims 1
- 239000002562 thickening agent Substances 0.000 abstract description 11
- 150000004665 fatty acids Chemical class 0.000 abstract description 7
- 230000001804 emulsifying effect Effects 0.000 abstract description 4
- 150000002191 fatty alcohols Chemical class 0.000 abstract description 4
- 229920000223 polyglycerol Polymers 0.000 abstract description 2
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- 239000012071 phase Substances 0.000 description 74
- 230000000052 comparative effect Effects 0.000 description 12
- 239000002994 raw material Substances 0.000 description 12
- 239000006071 cream Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 239000000523 sample Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 238000003756 stirring Methods 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 239000002736 nonionic surfactant Substances 0.000 description 4
- 230000001835 salubrious effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 230000007704 transition Effects 0.000 description 3
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- FEBUJFMRSBAMES-UHFFFAOYSA-N 2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(OC2C(C(OP)C(O)C(CO)O2)O)C(O)C(OC2C(C(CO)OC(P)C2O)O)O1 FEBUJFMRSBAMES-UHFFFAOYSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920002305 Schizophyllan Polymers 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940075510 carbopol 981 Drugs 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 238000010237 hybrid technique Methods 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention discloses a phase inversion emulsifying body, which adopts the technical scheme that polyglycerol fatty acid ester, long-carbon-chain fatty acid and/or long-carbon-chain fatty alcohol are matched with polyacrylic acid thickening agent, and has the characteristics of appearance, state and performance between O/W and W/O, refreshing, light and moist of O/W, moist and luxurious of W/O and long-lasting effect of the two.
Description
Technical field
The present invention relates to a kind of novel Phase inversion emulsification body and preparation methods, and it includes the polyglycerol fatty acids of special ratios
Ester, Long carbon chain fatty acid and/or Long carbon chain fatty alcohol and agent for polyacrylic acid thickening.
Background technique
Emulsification be often referred to cannot hybrid technique that mutually miscible oil is scattered in water or is scattered to moisture in oil, and
The dispersion that its result prepares is referred to as emulsified body.Emulsified body is in cosmetics, food, pharmacy and high molecular material cream
The fields extensive applications such as liquid polymerization.
In cosmetics industry, emulsified body is a kind of particularly useful and most widely used dosage form, most of cream
Frost, lotion and partial Essence and sleep mask are emulsified body.It is finer that emulsification can be such that cosmetics are made to,
It is formulated more flexible, is easier to according to demand with parameters such as the thixotropy, viscosity, appearance and the use feelings that improve product.In addition, emulsification
Body is the good carrier of active matter, it uniformly effectively can be imposed on skin.
Currently, emulsified body in the market is mostly oil-in-water type (O/W) or water-in-oil type (W/O), but every kind of emulsified body
There is a respective strengths and weaknesses, O/W emulsified body does not stick clearly greasy, firmly gets the majority of consumers and likes, but not enough moistens relatively, moisturizing
Not persistently, it applies in foundation cream and sunscreen product, not anti-sweat even more not resistant to water；W/O emulsified body is usually used in foundation cream, sun-proof, water outlet
Frost and winter product, moisturizing, lasting moisturizing, relatively water-fast sweat proof, but also it is thick and heavy stick it is greasy, and produce after pot
Furnace, production apparatus, vessel are smooth greasy, it is difficult to clean.
Based on above-mentioned limitation is improved, with the progress of science, new emulsifying technology is continued to bring out.
A kind of phase inversion point emulsion process (EIP method), concrete principle are described in " Phase inversion emulsification " that Jiang Yingtao is delivered in detail
Are as follows: water phase is added dropwise in the oily phase containing surfactant, initially, since the volume fraction of water is too low, although there is Gao Qinshui
The interfacial film of lipophilic balance value (HLB value) surfactant composition is also not enough to its flexural rigidity and keeps its natural curvature (curved
To oil), and form water-in-oil system.When the volume fraction of water, which reaches understanding, piles up value (phase inversion point), two power are unexpected with joint efforts
Phase inversion is at oil-in-water system.EIP is indicated with the cubic centimetre number of the added water of oily phase per cubic centimeter when phase transition.
In " selection (having continued) of emulsification and its application in cosmetic industry (three) emulsifier " that Qiu Ping Yi is delivered
Detail a kind of phase transition temperature method (PIT method), concrete principle are as follows: solubility, the HLB value of nonionic surfactant be with
Temperature and significant changes.When temperature increases, the hydrophilic group hydration levels of nonionic surfactant are reduced, so that it is hydrophilic to reduce its
Property, HLB value reduces.Therefore, for a certain specific nonionic surfactant (as contained polyoxyethylated non-ionic surface active
Agent)-oil-water system, there is a relatively narrow temperature ranges, and above this temperature, nonionic surfactant is dissolved in oily phase, and
It is soluble in the aqueous phase below the temperature, when temperature gradually decreases, system is changed into O/W type by w/o type.The temperature of phase inversion wherein occurs
Degree is known as phase transition temperature (PIT).
However, these prior arts all without introduction or suggest fully considering other raw materials in emulsified body formula, especially
Influence of the thickener to phase conversion emulsifying let alone recognizes or is understood by other ingredients in selection thickener and system
Compatibility and any unique benefit realized.
After a lot of research work conducted in the Phase inversion emulsification body field that the present inventor is previously mentioned, out
It has found with expecting, polyglyceryl fatty acid ester, Long carbon chain fatty acid and/or Long carbon chain fatty alcohol, collocation polyacrylic increases
Thick dose, due in agent for polyacrylic acid thickening and when can quickly snatch away a part of water in conjunction with emulsifier so that newborn
Change body and phase inversion occurs, a kind of appearance, state, performance has been made between O/W and W/O, existing O/W's is salubrious, light
It is full of He Shuirun, also there is the moist luxury of W/O, the novel Phase inversion emulsification body (Oil-in-water of the length of the two that gets both
Tranfer to water-in-oil, abbreviation WTO emulsified body).
Summary of the invention
The purpose of the present invention is to provide a kind of Phase inversion emulsification bodies, use polyglyceryl fatty acid ester, Long carbon chain fatty acid
And/or Long carbon chain fatty alcohol, the technical solution for agent for polyacrylic acid thickening of arranging in pairs or groups have appearance, state, performance between O/W
Between W/O, salubrious, the slim and graceful and water profit of existing O/W also have the moist luxury of W/O, the spy of the length of the two that gets both
Point.
The specific technical solution of the present invention is as follows:
A kind of Phase inversion emulsification body, it includes the total weights for pressing the Phase inversion emulsification body:
(a) polyglyceryl fatty acid ester of 1-3%；
(b) the Long carbon chain fatty acid and/or Long carbon chain fatty alcohol of 0.5-3%；
(c) agent for polyacrylic acid thickening of 0.1-1%；And
(d) pH adjusting agent of 0.05-1%;Wherein the HLB value of the polyglyceryl fatty acid ester is 7-12.
In wherein some embodiments, the content of the agent for polyacrylic acid thickening is 0.5-1wt%.
In wherein some embodiments, the Phase inversion emulsification body further includes the hydrophilic macromolecule of (e) 0.05-0.5wt%
Polymer.
The invention further relates to the purposes that above-mentioned Phase inversion emulsification body is used for skin care item.Can by adjusting thickener, emulsifier,
The methods of oil water phase ratio prepares the skin care item of different dosage forms, such as cream, lotion, Essence, sleep mask.
The preparation process of Phase inversion emulsification body of the present invention is similar with the preparation process of common oil-in-water emulsion, mainly
Steps are as follows: Aqueous Phase Raw Material being mixed, is uniformly dispersed, is heated to 80-85 DEG C, water phase is made；Oily phase raw material is mixed, dispersion is equal
It is even, it is heated to 80-85 DEG C, oil phase is made；Oil is added in water phase under stiring, is opened homogeneous 3-5 minutes；Stirring decline
PH adjusting agent is added to 60 DEG C in temperature；Room temperature is cooled under stirring, it is qualified to examine, and can discharge.
Technical solution provided in an embodiment of the present invention has the benefit that
(1) the present invention provides a kind of Phase inversion emulsification bodies, use polyglyceryl fatty acid ester O/W emulsifier, Long carbon chain fatty acid
And/or Long carbon chain fatty alcohol, the technical solution of the polymer for high-content of arranging in pairs or groups have appearance, state, performance between O/W
Between W/O, salubrious, the slim and graceful and water profit of existing O/W also have the moist luxury of W/O, the spy of the length of the two that gets both
Point.
(2) preparation process of Phase inversion emulsification body of the present invention is easy, is easy to be mass produced, and does not need using EIP
The dropwise addition process of that time and effort consuming of method, does not need strict temperature control as PIT method yet.
Detailed description of the invention
The molten water situation map of Fig. 1 embodiment I；
The molten water situation map of Fig. 2 embodiment II；
The molten water situation map of Fig. 3 embodiment III；
The molten water situation map of Fig. 4 embodiment IV；
The molten water situation map of Fig. 5 Comparative Examples I；
The molten water situation map of Fig. 6 Comparative Example II；
The molten water situation map of Fig. 7 Comparative Example II I；
The molten water situation map of the commercially available Water-In-Oil face cream of Fig. 8.
Specific embodiment
The feature and beneficial effect of various embodiments of the present invention will be become apparent by following explanation, the explanation
It is directed to the example of the specific embodiment represented extensively of the invention.It is a variety of from these descriptions and from practice of the invention
Modification will be apparent to those skilled in the art.The scope of the present invention is not limited to disclosed specific shape
Formula, and present invention encompasses the modification fallen in the spirit and scope of the invention as defined by the appended claims,
Equivalent form and alternative form.
A. emulsifier
Emulsifier suitable for Phase inversion emulsification body of the present invention is polyglyceryl fatty acid ester.Polyglyceryl fatty acid ester is a kind of temperature
And emulsifier, it is made of being esterified at high temperature as natural glycerin and fatty acid, lipophilic group is the ester that reaction generates, and hydrophilic group is
Unreacted hydroxyl.By changing the degree of polymerization, the type of acidification value and fatty acid of glycerol, available a series of difference
The polyglyceryl fatty acid ester of HLB value (hydrophilic lipophilic balance).The suitable HLB value of polyglyceryl fatty acid ester according to the present invention
It is about 7-12, or about 8-10.
It include -2 laurate of polyglycereol for the exemplary polyglyceryl fatty acid ester emulsifier in Phase inversion emulsification body, poly-
- 2 stearate of glycerol, Natrulon H-10 myristinate, -3 distearate of polyglycereol and their mixture.
Phase inversion emulsification body may include based on the weight of the Phase inversion emulsification body about 1% to 3%, or about 1.5% to about 2.5%
Emulsifier.
B. assistant for emulsifying agent
Assistant for emulsifying agent is the important component in emulsified body, be can be adsorbed on oil-water interfaces, and interfacial tension is further decreased, and is increased
The mobility of strong interface film reduces bending energy required when emulsified body formation, plays positive effect to the stability of system.
Assistant for emulsifying agent suitable for Phase inversion emulsification body of the present invention can be Long carbon chain fatty acid and/or Long carbon chain fat
Alcohol.
Suitable for assistant for emulsifying agent of the present invention Long carbon chain fatty acid have about 10 to 30 carbon atoms, preferably from about 16 to
The fatty acid of 22 carbon atoms.The fatty acid is saturation, and can be straight-chain acid or branched acids, can be unitary
Acid, binary acid and other polyacids.
For the Exemplary fatty acid in Phase inversion emulsification body include lauric acid, palmitinic acid, myristic acid, behenic acid,
Decanedioic acid and their mixture.
Suitable for assistant for emulsifying agent of the present invention Long carbon chain fatty alcohol have about 14 to 30 carbon atoms, preferably from about 16 to
The fatty alcohol of 22 carbon atoms.The fatty alcohol is saturation, and can be straight chain alcohol or branched-chain alcoho.
For the Exemplary fatty alcohol in Phase inversion emulsification body include cetanol, stearyl alcohol, cetostearyl alcohol, docosanol with
And their mixture.
Phase inversion emulsification body may include based on the weight of the Phase inversion emulsification body about 0.5% to about 3%, or about 1% to about 2%
Assistant for emulsifying agent.
C. water phase thickener
Water phase thickener is the usual component in emulsified body, can improve and adjust viscosity, is stablized, anti-settling, thixotroping etc.
Performance.
Water phase thickener suitable for Phase inversion emulsification body of the present invention is mainly agent for polyacrylic acid thickening.Polyacrylic acid
On the strand of class thickener contain a certain amount of carboxyl, when with alkali neutralization, can rapid water swelling, increase system suddenly
Viscosity.Inventors hereof have unexpectedly found that in polyglyceryl fatty acid ester, Long carbon chain fatty acid and/or long carbon
Chain fatty alcohol, collocation agent for polyacrylic acid thickening constitute specific emulsified body in, due in agent for polyacrylic acid thickening and when can
Quickly to snatch away a part of water in conjunction with emulsifier so that phase inversion occurs for emulsified body, be made a kind of appearance, state,
The special Phase inversion emulsification body of performance.
It include carbomer, acrylic acid (ester) class/C10- for the exemplary polypropylene Acrylic associative thickener in Phase inversion emulsification body
30 alkylol acrylamide acid esters cross-linked polymers, acrylic acid (ester) analog copolymer and their mixture.
Suitable carbomer may include trade name " Carbopol 676 ", " Carbopol 934 ", " Carbopol
940”、“Carbopol 941”、“Carbopol 980”、“Carbopol 981”、“Carbopol Ultrez 10”、
The raw material of " Carbopol Ultrez 30 ", " Carbopol Silk 100 " (come from the limited public affairs of U.S. Lu Borun special type chemical industry
Department)；Suitable carbomer also may include trade name " TC-CARBOMER 340 ", " TC-CARBOMER 380 ", " TC-
CARBOMER 351”、“TC-CARBOMER 356”、“TC-CARBOMER 381”、“TC-CARBOMER 276”、“TC-
CARBOMER 334 ", " TC-CARBOMER 341 ", " TC-CARBOMER 396 ", the raw material of " TC-CARBOMER 390 " are (next
From Guangzhou Tianci Advanced Materials Co., Ltd)；Suitable carbomer also may include trade name " AQUPEC HV-
The raw material (refining Co., Ltd. from SUMITOMO CHEMICAL) of 505HC ", " AQUPEC HV-501 "；Suitable carbomer also may include
The raw material (coming from 3V SIGMA company, Italy) of trade name " Polygel CA ", " Polygel CB ".
Suitable acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer may include trade name
“Carbopol ETD 2020”、“Carbopol Ultrez 21”、“Carbopol Ultrez 20”、“Carbopol SC-
200 ", raw material (coming from U.S. Lu Borun special type Chemical Co., Ltd.) company of " Pemulen TR-1 ", " Pemulen TR-2 "；
Suitable acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer also may include trade name " TC-
The raw material (coming from Guangzhou Tianci Advanced Materials Co., Ltd) of CARBOMER FD2010 ".
Suitable acrylic acid (ester) analog copolymer may include trade name " Carbopol Aqua SF-1 ",
The raw material (coming from U.S. Lu Borun special type Chemical Co., Ltd.) of " Carbopol Aqua SF-2 "；It also may include trade name
The raw material (coming from 3V SIGMA company, Italy) of " Synthalen W400 ".
Phase inversion emulsification body may include based on the weight of the Phase inversion emulsification body about 0.1% to about 1%, or about 0.5% to about
1% agent for polyacrylic acid thickening.
The purposes of pH adjusting agent of the present invention is to neutralize agent for polyacrylic acid thickening.The non-limit of pH adjusting agent
Property example processed includes aminomethyl propanol, aminomethyl propylene glycol, tromethamine, arginine, triethanolamine, potassium hydroxide, sodium hydroxide
And their mixture.The additive amount of the pH adjusting agent about 0.05% to about 1%.
Water phase thickener suitable for Phase inversion emulsification body of the present invention can also include hydrophilic high molecular polymer.This
Invention assists making inventors have found that adding a certain amount of hydrophilic high molecular polymer and having the phase inversion process of Phase inversion emulsification body
With.Hydrophilic high molecular polymer can be natural, be also possible to artificial synthesized, non-limiting example includes that the Chinese is raw
Glue, tremella (TREMELLA FUCIFORMIS) polysaccharide, Sodium Hyaluronate, hydroxyethyl cellulose, guar gum, Scleroglucan and
Their mixture.
Phase inversion emulsification body may include based on the weight of the Phase inversion emulsification body about 0.05% to about 0.5%, or about 0.1% to
About 0.3% hydrophilic high molecular polymer.
Embodiment and data
Following embodiment shows Phase inversion emulsification body as described herein.Illustrative composition can pass through conventional formulation and emulsifying technology
To prepare.It should be appreciated that without departing from the spirit and scope of the present invention, the technical staff in field of daily chemicals
Other modifications can be carried out to the present invention.Unless otherwise specified, all numbers, percentage and percentage are by weight herein.
Some ingredients can come from supplier in the form of weak solution.Unless otherwise specified, the amount reflects the weight hundred of active material
Divide ratio.
Prepare the emulsified body of 4 kinds of exemplary Phase inversion emulsification bodies and 3 kinds of comparisons.Table 1 specific as follows, table 2:
1 embodiment I ~ IV of table
2 Comparative Examples Is of table ~ III
Preparation method: the above embodiments I ~ IV and Comparative Examples I ~ III's the preparation method is as follows:
(1) by emulsifier (such as: -2 laurate of polyglycereol, Natrulon H-10 myristinate, -2 stearate of polyglycereol),
Assistant for emulsifying agent (such as: cetostearyl alcohol, stearic acid), dormant oil, ring five dimethyl silicone polymer, cyclohexasiloxane, the poly- isobutyl of hydrogenation
Alkene, Nipasol put into oily phase pot, and mixing is uniformly dispersed, is heated to 80-85 DEG C, and oil phase is made；
(2) by water, methyl hydroxybenzoate, EDTA disodium, butanediol, glycerol, water phase thickener (such as: carbomer, tremella (
TREMELLA FUCIFORMIS) polysaccharide, xanthan gum) investment emulsion pot, mixing is uniformly dispersed, is heated to 80-85 DEG C, obtained
Water phase；
(3) oil is added in water phase by oily phase raw material under stiring, is opened homogeneous 3-5 minutes；
(4) 60 DEG C are cooled under stirring, and are added pH adjusting agent (such as: triethanolamine, arginine)；
(5) room temperature is cooled under stirring, it is qualified to examine, and can discharge.
In order to show the characteristic of Phase inversion emulsification body obtained by above-described embodiment and comparative example, the following test of arrangement:
(1) stability test
1., sample obtained by embodiment I ~ IV, Comparative Examples I ~ III is respectively placed in 45 DEG C, 5 DEG C, subzero 8 DEG C of environment it is next
Month, phenomena such as layering is demulsified, is coarse, is obvious thinning is seen whether, to investigate steadiness.
3 stability record sheet of table
As seen from Table 3, the Phase inversion emulsification body of preparation of the embodiment of the present invention passed through 45 DEG C of 20 days, 5 DEG C, it is 8 DEG C subzero
Stability test, the Phase inversion emulsification body are a metastable emulsified bodies.
2., by sample obtained by embodiment I ~ IV, Comparative Examples I ~ III, stood after discharging for 24 hours, 5d, 30d carry out
The centrifugation of 3000rpm, 30min are tested.Whether observation is stablized using being layered as by index with investigating the centrifugation of Phase inversion emulsification body
Implementations.
4 centrifugal stability record sheet of table
From table 4, it can be seen that Phase inversion emulsification body made from the embodiment of the present invention has passed through centrifugation test in different time periods, show
Phase inversion emulsification body of the invention is a metastable emulsified body, it is not easy to passage at any time and change.
It can be seen that heat-resisting cold-resistant, the centrifugation test of Phase inversion emulsification body provided by the present invention all meets " QB/T 1857
Moisturizing cream ", the physical and chemical index of " 29665 facial treatment milk of GB/T " defined.
(2) characteristic test
1., sample obtained by embodiment I ~ IV, Comparative Examples I ~ III and commercially available Water-In-Oil face cream respectively taken into 1g, put into respectively
In 100g deionized water, stirs 1 minute, then observe molten regimen condition, concrete condition is shown in Table 5 and attached drawing 1-8.
The molten water record sheet of table 5
From table 5 and attached drawing 1-8 as it can be seen that the solubization energy and oil-in-water emulsified of Phase inversion emulsification body obtained by the embodiment of the present invention
Body, Water-In-Oil emulsified body are all different.
2., conductivity survey is carried out to sample obtained by embodiment I ~ IV, Comparative Examples I ~ III and commercially available Water-In-Oil face cream
Examination.It is stood after discharging for 24 hours, the probe of conductivity meter is inserted directly into sample and is read, physical record is shown in Table 6.
6 conductivity test reading of table
As seen from Table 6, the conductivity of Phase inversion emulsification body obtained by the embodiment of the present invention is identical as Water-In-Oil emulsified body, with water packet
The Comparative Examples I of oil systems ~ III is different.
3., smearing test is carried out to sample obtained by embodiment I, Comparative Examples I and commercially available Water-In-Oil face cream.Specific test
Method is to take 0.1g Material as the back of the hand, is looped with the middle finger and the third finger closed up and is applied to absorption, carefully experiences smearing process
In use feeling, and recorded such as the following table 7.
Table 7 smears test
As seen from Table 7, Phase inversion emulsification body obtained by the embodiment of the present invention in rigid smear, moisten by use feeling, then in smearing
Use feeling is converted into water profit suddenly, finally moistens and oiliness.
To sum up, a kind of appearance, state, performance has been made between O/W and W/O in the present invention, existing O/W
It is salubrious, slim and graceful moisten with water, also have the moist luxury of W/O, the novel Phase inversion emulsification body of the length of the two that gets both.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.
Claims (10)
1. a kind of Phase inversion emulsification body, which is characterized in that the total weight comprising pressing the Phase inversion emulsification body:
(a) polyglyceryl fatty acid ester of 1-3%；
(b) the Long carbon chain fatty acid and/or Long carbon chain fatty alcohol of 0.5-3%；
(c) agent for polyacrylic acid thickening of 0.1-1%；And
(d) pH adjusting agent of 0.05-1%;Wherein the HLB value of the polyglyceryl fatty acid ester is 7-12.
2. Phase inversion emulsification body according to claim 1, which is characterized in that the content of the agent for polyacrylic acid thickening is
0.5-1wt%。
3. Phase inversion emulsification body according to claim 1, which is characterized in that the Phase inversion emulsification body further includes (e) 0.05-
The hydrophilic high molecular polymer of 0.5wt%.
4. Phase inversion emulsification body according to claim 1, which is characterized in that the polyglyceryl fatty acid ester emulsifier is poly-
- 2 laurate of glycerol, -2 stearate of polyglycereol, Natrulon H-10 myristinate, -3 distearate of polyglycereol with
And their mixture.
5. Phase inversion emulsification body according to claim 1, which is characterized in that the Long carbon chain fatty acid is lauric acid, palm fibre
Palmitic acid acid, myristic acid, behenic acid, decanedioic acid and their mixture.
6. Phase inversion emulsification body according to claim 1, which is characterized in that the Long carbon chain fatty alcohol is cetanol, firmly
Lipidol, cetostearyl alcohol, docosanol and their mixture.
7. Phase inversion emulsification body according to claim 1, which is characterized in that the agent for polyacrylic acid thickening is card wave
Nurse, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, acrylic acid (ester) analog copolymer and theirs is mixed
Close object.
8. Phase inversion emulsification body according to claim 1, which is characterized in that the pH adjusting agent be aminomethyl propanol,
Aminomethyl propylene glycol, tromethamine, arginine, triethanolamine, potassium hydroxide, sodium hydroxide and their mixture.
9. the described in any item Phase inversion emulsification bodies of claim 1-8 are in the purposes of skin care item.
10. a kind of Phase inversion emulsification body, which is characterized in that the Phase inversion emulsification body includes the component of following mass percentage:
- 2 laurate 2% of polyglycereol, cetostearyl alcohol 1%, dormant oil 5%, ring five dimethyl silicone polymer 0.9%, cyclohexasiloxane
0.6%, Parleam 2%, Nipasol 0.05%, methyl hydroxybenzoate 0.15%, EDTA disodium 0.03%, butanediol 8%, sweet
Oily 2%, carbomer 0.5%, tremella (TREMELLA FUCIFORMIS) polysaccharide 0.2%, triethanolamine 0.5%, Phenoxyethanol
0.3%, water surplus.
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| CN110859761A (en) * | 2019-11-29 | 2020-03-06 | 广州欧正化妆品技术研究院有限公司 | Water-in-oil phase inversion emulsion spray and preparation method thereof |
| CN112691065A (en) * | 2021-02-08 | 2021-04-23 | 福建片仔癀化妆品有限公司 | Moisturizing emulsion and preparation method thereof |
| CN115844769A (en) * | 2022-12-26 | 2023-03-28 | 上海家化联合股份有限公司 | Stable emulsion system containing oil globule composition |
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| CN114259427A (en) * | 2022-01-10 | 2022-04-01 | 广州睿新生物科技有限公司 | Instant water-discharging cream and its preparation method |
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