CN110426372B - Elastic modulus imaging detection method for frequency-sweeping Brillouin scatterer - Google Patents
Elastic modulus imaging detection method for frequency-sweeping Brillouin scatterer Download PDFInfo
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- CN110426372B CN110426372B CN201910638694.4A CN201910638694A CN110426372B CN 110426372 B CN110426372 B CN 110426372B CN 201910638694 A CN201910638694 A CN 201910638694A CN 110426372 B CN110426372 B CN 110426372B
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- 238000001514 detection method Methods 0.000 title claims abstract description 25
- 238000003384 imaging method Methods 0.000 title claims abstract description 14
- 238000010408 sweeping Methods 0.000 title description 4
- 230000003595 spectral effect Effects 0.000 claims abstract description 12
- 238000004364 calculation method Methods 0.000 claims abstract description 3
- 230000003287 optical effect Effects 0.000 claims description 13
- 230000005284 excitation Effects 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 230000008033 biological extinction Effects 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 2
- 238000005516 engineering process Methods 0.000 abstract description 4
- 238000002091 elastography Methods 0.000 abstract description 3
- 230000001360 synchronised effect Effects 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 description 6
- 238000003745 diagnosis Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 201000002287 Keratoconus Diseases 0.000 description 1
- 238000000701 chemical imaging Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
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Abstract
The invention provides a scanning frequency type Brillouin scatterer elastic modulus imaging detection method, which adopts a spectrometer system consisting of a scanning frequency type F-P interferometer and a photon receiver, a computer generates a driving program to control the synchronous operation of the scanning frequency type F-P interferometer and the photon receiver, further scanning and collecting a Brillouin scattering signal excited by 532nm laser in biological tissues, then a Brillouin scattering spectrogram of a sample is obtained by processing the Brillouin scattering signal by the computer, further Brillouin frequency shift of the biological tissues is obtained, and then the bulk elastic modulus of the biological tissues is obtained by calculation according to the physical relation between the Brillouin scattering frequency shift and the bulk elastic modulus of the biological tissues. The invention has the advantages that: the frequency sweep type F-P interferometer and the photon receiver are adopted to form a spectrometer system, so that the spectral resolution of the Brillouin scattering system is improved, the detection speed is improved, the overall detection time is shortened, and the clinical operability of the Brillouin scattering spectral elastography technology is improved.
Description
Technical Field
The invention relates to an imaging detection method of bulk elastic modulus, in particular to a scanning frequency type Brillouin scatterer elastic modulus imaging detection method.
Background
The invention relates to a bulk elastic modulus imaging detection mode, which mainly detects the frequency shift of a Brillouin scattering spectrum of a sample by a spectrometer consisting of a frequency sweep type F-P interferometer and a photon receiver, and then calculates and obtains the bulk elastic modulus of the sample to be detected according to the physical relationship between the frequency shift of a Brillouin scattering signal and the bulk elastic modulus of the sample.
The Brillouin scattering elastography is used for detecting the body elastic modulus of an ophthalmic biological tissue, and has wide application prospects in the fields of diagnosis, treatment and prevention of ophthalmic clinical diseases (myopia, keratoconus and the like), but at present, some technical limitations still exist, mainly the spectral resolution of a detection system is low, and Brillouin frequency shift signals cannot be distinguished from Rayleigh signals with high precision; in addition, most of the existing brillouin imaging technologies use a virtual phased array spectrometer (VIPA) to detect brillouin frequency shift signals, and the detection time is long, so that the detection has certain limitations in clinical application.
Disclosure of Invention
The invention aims to provide a method for detecting elastic modulus imaging of a frequency-sweeping Brillouin scatterer. Because the spectral frequency shift signal of brillouin scattering represents the acousto-optic effect at the molecular level, and different biomechanical properties have different influence degrees on the brillouin scattering spectral frequency shift signal, the brillouin scattering spectral imaging technology for detecting the elastic property of biological tissues has higher resolution, but the currently mainstream technical means is to use a virtual phased array spectrometer (VIPA) to scan and detect the brillouin scattering spectral signal, and the resolution and the detection time of the method are both to be improved.
The invention adopts a frequency sweep type F-P interferometer to scan the Brillouin scattering spectrum, then adopts a photon receiver to realize the acquisition and processing of the spectrum signal, and processes the spectrum signal on a computer to obtain the frequency shift signal of the Brillouin scattering spectrum, thereby further calculating the bulk modulus of the sample to be detected, and the detection result has important reference value and wide application prospect for solving the diagnosis, treatment and prevention of the clinical multiple ophthalmic diseases at present. The experimental detection device utilizing the method comprises a power-adjustable 532nm continuous laser, a 95:5 spectroscope, a 532nm reflector I, a 532nm reflector II, an opening dark box, a three-dimensional moving lifting table, a sample, a focusing objective lens, a pinhole filter, a convex lens I, a small-hole diaphragm, a convex lens II, a sweep frequency type F-P interferometer, a convex lens III, a photon receiver and a computer.
The specific process of the detection method is that a power-adjustable continuous laser emits a laser beam with the wavelength of 532nm, the laser beam is divided into two beams of light which are vertical to each other and have the power ratio of 95:5 through a 95:5 spectroscope, wherein a reference beam with the power of 5 percent enters a sample on a three-dimensional moving lifting platform through an opening dark box, the sample is placed at the focus of a focusing objective lens, the sample is focused by the focusing objective lens and enters a pinhole filter to filter stray light, emergent light enters the focus of a convex lens I and becomes parallel light after passing through the convex lens I, the parallel light is spatially filtered through a pinhole diaphragm to improve the signal-to-noise ratio, the emergent light enters a sweep frequency type F-P interferometer arranged at the focus of a convex lens II through a convex lens II, the sweep frequency type F-P interferometer generates a driving program under the control of a computer and is used for scanning the light signal, the emergent light enters the focus of the convex lens III and is focused to a signal receiving end of a photon receiver through the convex lens III, the photon receiver is controlled by a computer to generate a driving program matched with the sweep frequency F-P to be used for receiving optical signals, and the whole reference optical path is used for adjusting the coaxiality of all optical components of the signal receiving optical path of the system. Another excitation light with 95% power passes through the 532nm reflector and the 532nm reflector 4 to be changed into a direction vertical to a reference light beam with 5% power, then the excitation light enters a sample on the three-dimensional moving lifting platform through the opening camera bellows, a 360-degree Brillouin scattering signal is excited, forward scattering light enters the extinction device, at the moment, a reference light path of the opening camera bellows is shielded, only the incidence of the excitation light of the system is reserved, then the focusing objective lens focuses the Brillouin scattering signal at 90 degrees in the lateral direction of the sample, the Brillouin scattering signal of the sample to be detected is received through the signal receiving light path, and finally the collection processing of the Brillouin scattering signal is completed through the photon receiver.
Further, a continuous 532nm laser (01) is adopted for excitation to generate a Brillouin scattering signal, and the Brillouin scattering signal with the lateral direction of 90 degrees is received.
Furthermore, the frequency sweep type F-P interferometer (13) is used for receiving the Brillouin scattering signal in a scanning mode, the spectral resolution of the frequency sweep type F-P interferometer (13) is 67MHz, the free spectral range is 10GHz, the Brillouin scattering signal is collected and processed by the photon receiver (15), and the calculation of the Brillouin scattering frequency shift is completed by the computer (16).
The invention has the advantages that: the frequency sweep type F-P interferometer and the photon receiver are adopted to form a spectrometer system, so that the spectral resolution of the Brillouin scattering system is improved, the detection speed is improved, the overall detection time is shortened, and the clinical operability of the Brillouin scattering spectral elastography technology is improved.
Drawings
Fig. 1 is a schematic diagram of the present invention.
FIG. 1 shows: the device comprises a power-adjustable 532nm continuous laser (01), a 95:5 spectroscope (02), a 532nm reflector I (3), a 532nm reflector II (4), a hole opening dark box (5), a three-dimensional moving lifting table (6), a sample (7), a focusing objective lens (8), a pinhole filter (9), a convex lens I (10), an aperture diaphragm (11), a convex lens II (12), a frequency-sweeping F-P interferometer (13), a convex lens III (14), a photon receiver (15), a computer (16) and an extinction device (17).
Detailed Description
A sweep frequency type Brillouin scatterer elastic modulus imaging detection method comprises the steps that a 532nm continuous laser 01 with adjustable power emits a laser beam with the wavelength of 532nm, the laser beam is divided into two paths of light beams with the power ratio of 95:5 through a 95:5 spectroscope 02, the light beam with the power of 5% serves as a reference light path and is directly incident to a sample 7 on a three-dimensional moving lifting platform 06 through an opening dark box 05, and the sample 7 is placed at the focus of a focusing objective lens 08.
The light is focused by a focusing objective lens 8 and enters a pinhole filter 9 to filter stray light, emergent light enters the focus of a convex lens I10 and becomes parallel light after passing through the convex lens I10, and spatial filtering and mode selection are carried out through a small aperture diaphragm 11, for improving the signal-to-noise ratio, and then enters the sweep frequency type F-P interferometer 13 placed at the focus of the convex lens II 12 through the focusing of the convex lens II 12, the sweep frequency type F-P interferometer 13 is controlled by the computer 16 to generate a driving program, the optical signal receiving device is used for scanning an optical signal, emergent light enters at the focus of the convex lens III 14 and is focused to a signal receiving end of the photon receiver 15 through the convex lens III 14, the photon receiver 15 is controlled by the computer 16 to generate a driving program matched with the frequency sweep F-P to receive the optical signal, and the whole reference optical path is used for adjusting the coaxiality of all optical components of the system signal receiving optical path.
Another excitation light with 95% power passes through a 532nm mirror I3 and a 532nm mirror II 4 to be changed into a direction vertical to a reference light beam with 5% power, then the excitation light enters a sample on the three-dimensional moving lifting platform through the opening camera bellows 5 to excite a 360-degree Brillouin scattering signal, forward scattering light enters the extinction device 17, at the moment, a reference light path of the opening camera bellows 5 is shielded, only the excitation light entering of a system light path is reserved, the focusing objective 8 focuses the Brillouin scattering signal at 90 degrees in the lateral direction of the sample, the Brillouin scattering signal of the sample to be detected is received through the signal receiving light path, and finally the photon receiver 15 finishes the collection processing of the Brillouin scattering signal.
The invention relates to a scanning frequency type Brillouin scatterer elastic modulus imaging detection method which is characterized in that the physical relation between the frequency shift quantity of a Brillouin scattering spectrum and the bulk elastic modulus of biological tissues is utilized, and the bulk elastic modulus of a sample is obtained through scanning detection of a sample Brillouin scattering frequency shift signal.
The invention relates to a scanning frequency type Brillouin scatterer elastic modulus imaging detection method which is characterized by adopting a detection method of a power-adjustable 532nm continuous laser 01, a 95:5 spectroscope 02, a 532nm reflector 3, a 532nm reflector 4, an open-hole dark box 5, a three-dimensional moving lifting platform 6, a sample 7, a focusing objective lens 8, a pinhole filter 9, a convex lens 10, a small-hole diaphragm 11, a convex lens 12, a scanning frequency type F-P interferometer 13, a convex lens 14, a photon receiver 15, a computer 16 and an extinction device 17.
The invention relates to a scanning frequency type Brillouin scatterer elastic modulus imaging detection method which is characterized in that a power-adjustable continuous laser 01 with the output wavelength of 532nm is adopted to generate a Brillouin scattering signal, and a scanning frequency type F-P interferometer and a photon receiver jointly form a spectrometer system for realizing high-precision scanning detection of the Brillouin scattering frequency shift signal.
Without being limited thereto, any changes or substitutions which are not thought of through creative efforts should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope defined by the claims.
Claims (2)
1. A frequency sweep type Brillouin scatterer elastic modulus imaging detection method is characterized in that a power adjustable continuous laser (01) emits a laser beam with the wavelength of 532nm, the laser beam is divided into two beams of light which are perpendicular to each other and have the power ratio of 95:5 through a 95:5 spectroscope (02), wherein a reference beam with the power of 5% enters a sample (7) on a three-dimensional moving lifting platform (6) through an opening dark box (5), the sample is placed at the focus of a focusing objective lens, the sample is focused through the focusing objective lens (8) and enters a pinhole filter (9) to filter stray light, emergent light enters the focus of a convex lens I (10), becomes parallel light after passing through the convex lens I (10), is subjected to spatial filtering through a pinhole diaphragm (11) to improve the signal-to-noise ratio, is focused through a convex lens II (12) and enters a frequency sweep type F-P interferometer (13) placed at the focus of the convex lens II (12), the sweep frequency type F-P interferometer (13) is controlled by a computer (16) to generate a driving program for scanning an optical signal, emergent light is incident at the focus of a convex lens III (14) and is focused to a signal receiving end of a photon receiver (15) through the convex lens III (14), the photon receiver (15) is controlled by the computer (16) to generate the driving program matched with the sweep frequency F-P for receiving the optical signal, the whole reference light path is used for adjusting the coaxiality of optical components of each part of a system signal receiving light path, the other excitation light with the power of 95 percent is changed into a direction vertical to a reference light beam with the power of 5 percent through a 532nm reflector (3) and a 532nm reflector (4) and then is incident to a sample on a three-dimensional moving lifting platform through an opening dark box (5) to excite a 360-degree Brillouin scattering signal, and forward scattering light is incident to an extinction device (17), at the moment, a reference light path of the open-hole dark box (5) is shielded, only the incidence of the exciting light of the system is reserved, then the Brillouin scattering signal is focused by a focusing objective lens (8) at 90 degrees in the lateral direction of the sample, the Brillouin scattering signal of the sample to be measured is received through a signal receiving light path, and finally the collection processing of the Brillouin scattering signal is completed through a photon receiver (15).
2. A method for detecting elastic modulus imaging of a swept-frequency brillouin scatterer according to claim 1, wherein: the Brillouin scattering frequency shift calculation method is characterized in that a frequency sweep type F-P interferometer (13) is used for receiving Brillouin scattering signals in a scanning mode, the spectral resolution of the frequency sweep type F-P interferometer (13) is 67MHz, the free spectral range is 10GHz, a photon receiver (15) is used for collecting and processing the Brillouin scattering signals, and a computer (16) is used for calculating the Brillouin scattering frequency shift.
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| CN110879249B (en) * | 2019-11-29 | 2022-06-03 | 南昌航空大学 | System device for measuring limit shear modulus of biological Newtonian fluid |
| CN112782125B (en) * | 2020-12-31 | 2023-02-28 | 西安理工大学 | Biological tissue elastic modulus measuring device and method |
| CN113189054A (en) * | 2021-04-02 | 2021-07-30 | 南昌航空大学 | System device for non-invasive laser Brillouin skin elasticity measurement |
Citations (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0348235A2 (en) * | 1988-06-24 | 1989-12-27 | Nippon Telegraph and Telephone Corporation | Optical fiber evaluation methods and system using Brillouin amplification |
| EP0422468A2 (en) * | 1989-10-10 | 1991-04-17 | Hughes Aircraft Company | Self-pumped, optical phase conjugation method and apparatus using pseudo-conjugator to produce retroreflected seed beam |
| EP0874477A2 (en) * | 1997-04-25 | 1998-10-28 | Oki Electric Industry Co., Ltd. | Signal transmission system and method for supervising the same |
| US6348967B1 (en) * | 1992-07-08 | 2002-02-19 | Active Impulse Systems, Inc. | Method and device for measuring the thickness of opaque and transparent films |
| US6370164B1 (en) * | 1996-12-23 | 2002-04-09 | Xtera Communications, Inc. | Broadband sagnac raman amplifiers and cascade lasers |
| EP1237305A2 (en) * | 2001-02-28 | 2002-09-04 | KiloLambda IP Limited | Multi-wavelength light source |
| WO2003014178A1 (en) * | 2001-08-07 | 2003-02-20 | Inphase Technologies, Inc. | Process and composition for rapid mass production of holographic recording article |
| US6542683B1 (en) * | 1997-07-15 | 2003-04-01 | Corning Incorporated | Suppression of stimulated Brillouin scattering in optical fiber |
| EP1391693A1 (en) * | 2002-08-20 | 2004-02-25 | The Board of Trustees of The Leland Stanford Junior University | Fiber optic sensors with reduced noise |
| EP1630986A1 (en) * | 2004-08-27 | 2006-03-01 | Sumitomo Electric Industries, Ltd. | Analog optical transmission system |
| CN1833189A (en) * | 2003-09-03 | 2006-09-13 | 韩国科学技术院 | Apparatus and method for self-phase control in amplifier with stimulated brillouin scattering phase conjugate mirror |
| EP1746403A1 (en) * | 2005-07-19 | 2007-01-24 | Agilent Technologies, Inc. | Optical reflectometry analysis with a time-adjustment of partial responses |
| USRE42641E1 (en) * | 1997-06-02 | 2011-08-23 | Case Western Reserve University | Depth-resolved spectroscopic optical coherence tomography |
| CN102798850A (en) * | 2012-08-16 | 2012-11-28 | 中国科学技术大学 | Rayleigh-Doppler laser radar ground calibration system |
| CN102889959A (en) * | 2012-09-21 | 2013-01-23 | 南昌航空大学 | Device for measuring gas pressure based on Rayleigh-Brillouin scattering spectral characteristic |
| WO2013012495A2 (en) * | 2011-07-21 | 2013-01-24 | Baker Hughes Incorporated | System and method of distributed fiber optic sensing including integrated reference path |
| US8477308B1 (en) * | 2009-11-09 | 2013-07-02 | The United States Of America As Represented By The Secretary Of The Navy | Polarized, specular reflectometer apparatus |
| EP2796890A1 (en) * | 2011-12-21 | 2014-10-29 | Mitsubishi Electric Corporation | Laser radar device |
| CN104359839A (en) * | 2014-11-20 | 2015-02-18 | 南昌航空大学 | Rapid detection method for gutter oil |
| WO2015053736A1 (en) * | 2013-10-07 | 2015-04-16 | Halliburton Energy Services, Inc. | Optical power limiting method using stimulated brillouin scattering in fiber optic waveguides |
| WO2016124216A1 (en) * | 2015-02-02 | 2016-08-11 | Wavelight Gmbh | Optical instrument for biomechanical diagnosis of eye disease |
| CN106017685A (en) * | 2016-05-13 | 2016-10-12 | 中国海洋大学 | Sweep-frequency spectrum measurement method based on virtual image phase array |
| EP3118608A1 (en) * | 2014-03-10 | 2017-01-18 | Beijing Institute Of Technology | Method and apparatus for measuring light-splitting pupil laser differential motion confocal brillouin-raman spectrums |
| WO2017040959A1 (en) * | 2015-09-02 | 2017-03-09 | Seok-Hyun Yun | Performing a procedure based on monitored properties of biological tissues |
| WO2017112896A1 (en) * | 2015-12-22 | 2017-06-29 | Canon U.S. Life Sciences, Inc. | System and method of label-free cytometry based on brillouin light scattering |
| CN107764741A (en) * | 2017-09-28 | 2018-03-06 | 南昌航空大学 | A kind of detection means for integrating stimulated Brillouin scattering and optical coherence elastogram |
| CN107907507A (en) * | 2017-09-28 | 2018-04-13 | 南昌航空大学 | A kind of lubricating oil elasticity modulus detection method based on Brillouin scattering spectrum |
| CN108007582A (en) * | 2017-11-28 | 2018-05-08 | 南昌航空大学 | A kind of method and device based on the detection of Rayleigh Brillouin scattering optical maser wavelength |
| CN108828553A (en) * | 2018-04-19 | 2018-11-16 | 南昌航空大学 | A kind of system and device of stimulated Brillouin scattering laser radar simulation deep-sea detecting |
| CN109875504A (en) * | 2019-01-15 | 2019-06-14 | 温州医科大学 | One kind being based on the viscoelastic method of jet-propelled optical coherence elastography non-invasive measurement cornea |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7295356B2 (en) * | 2001-06-08 | 2007-11-13 | Inphase Technologies, Inc. | Method for improved holographic recording using beam apodization |
| US20060126682A1 (en) * | 2001-10-08 | 2006-06-15 | Geola Technologies Ltd. | Pulsed multiple colour laser system |
| US7199869B2 (en) * | 2003-10-29 | 2007-04-03 | Weatherford/Lamb, Inc. | Combined Bragg grating wavelength interrogator and Brillouin backscattering measuring instrument |
| JP4463818B2 (en) * | 2004-06-25 | 2010-05-19 | ニューブレクス株式会社 | Distributed optical fiber sensor |
| JP2006067364A (en) * | 2004-08-27 | 2006-03-09 | Sumitomo Electric Ind Ltd | Analog optical transmission system |
| US7725169B2 (en) * | 2005-04-15 | 2010-05-25 | The Board Of Trustees Of The University Of Illinois | Contrast enhanced spectroscopic optical coherence tomography |
| WO2007092911A2 (en) * | 2006-02-08 | 2007-08-16 | The General Hospital Corporation | Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy |
| GB2442486B (en) * | 2006-10-06 | 2009-01-07 | Schlumberger Holdings | Measuring brillouin backscatter from an optical fibre using a tracking signal |
| JP6143289B2 (en) * | 2013-07-16 | 2017-06-07 | 国立研究開発法人理化学研究所 | Lens elasticity measurement method, lens elasticity measurement device, and lens presbyopia determination device |
| WO2015010119A2 (en) * | 2013-07-19 | 2015-01-22 | The General Hospital Corporation | System, method and arrangements for modifying optical and mechanical properties of biological tissues |
| MX2016004378A (en) * | 2013-10-11 | 2016-08-17 | Wavelight Gmbh | Diagnosis system and diagnosis method. |
| US10598594B2 (en) * | 2015-12-22 | 2020-03-24 | University Of Maryland | Cell classification based on mechanical signature of nucleus |
-
2019
- 2019-07-16 CN CN201910638694.4A patent/CN110426372B/en not_active Expired - Fee Related
Patent Citations (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4997277A (en) * | 1988-06-24 | 1991-03-05 | Nippon Telegraph And Telephone Corporation | Optical fiber evaluation method and system |
| EP0348235A2 (en) * | 1988-06-24 | 1989-12-27 | Nippon Telegraph and Telephone Corporation | Optical fiber evaluation methods and system using Brillouin amplification |
| EP0422468A2 (en) * | 1989-10-10 | 1991-04-17 | Hughes Aircraft Company | Self-pumped, optical phase conjugation method and apparatus using pseudo-conjugator to produce retroreflected seed beam |
| US6348967B1 (en) * | 1992-07-08 | 2002-02-19 | Active Impulse Systems, Inc. | Method and device for measuring the thickness of opaque and transparent films |
| US6370164B1 (en) * | 1996-12-23 | 2002-04-09 | Xtera Communications, Inc. | Broadband sagnac raman amplifiers and cascade lasers |
| EP0874477A2 (en) * | 1997-04-25 | 1998-10-28 | Oki Electric Industry Co., Ltd. | Signal transmission system and method for supervising the same |
| USRE42641E1 (en) * | 1997-06-02 | 2011-08-23 | Case Western Reserve University | Depth-resolved spectroscopic optical coherence tomography |
| US6542683B1 (en) * | 1997-07-15 | 2003-04-01 | Corning Incorporated | Suppression of stimulated Brillouin scattering in optical fiber |
| EP1237305A2 (en) * | 2001-02-28 | 2002-09-04 | KiloLambda IP Limited | Multi-wavelength light source |
| WO2003014178A1 (en) * | 2001-08-07 | 2003-02-20 | Inphase Technologies, Inc. | Process and composition for rapid mass production of holographic recording article |
| EP1391693A1 (en) * | 2002-08-20 | 2004-02-25 | The Board of Trustees of The Leland Stanford Junior University | Fiber optic sensors with reduced noise |
| CN1833189A (en) * | 2003-09-03 | 2006-09-13 | 韩国科学技术院 | Apparatus and method for self-phase control in amplifier with stimulated brillouin scattering phase conjugate mirror |
| EP1630986A1 (en) * | 2004-08-27 | 2006-03-01 | Sumitomo Electric Industries, Ltd. | Analog optical transmission system |
| EP1746403A1 (en) * | 2005-07-19 | 2007-01-24 | Agilent Technologies, Inc. | Optical reflectometry analysis with a time-adjustment of partial responses |
| US8477308B1 (en) * | 2009-11-09 | 2013-07-02 | The United States Of America As Represented By The Secretary Of The Navy | Polarized, specular reflectometer apparatus |
| WO2013012495A2 (en) * | 2011-07-21 | 2013-01-24 | Baker Hughes Incorporated | System and method of distributed fiber optic sensing including integrated reference path |
| EP2796890A1 (en) * | 2011-12-21 | 2014-10-29 | Mitsubishi Electric Corporation | Laser radar device |
| CN102798850A (en) * | 2012-08-16 | 2012-11-28 | 中国科学技术大学 | Rayleigh-Doppler laser radar ground calibration system |
| CN102889959A (en) * | 2012-09-21 | 2013-01-23 | 南昌航空大学 | Device for measuring gas pressure based on Rayleigh-Brillouin scattering spectral characteristic |
| WO2015053736A1 (en) * | 2013-10-07 | 2015-04-16 | Halliburton Energy Services, Inc. | Optical power limiting method using stimulated brillouin scattering in fiber optic waveguides |
| EP3118608A1 (en) * | 2014-03-10 | 2017-01-18 | Beijing Institute Of Technology | Method and apparatus for measuring light-splitting pupil laser differential motion confocal brillouin-raman spectrums |
| CN104359839A (en) * | 2014-11-20 | 2015-02-18 | 南昌航空大学 | Rapid detection method for gutter oil |
| WO2016124216A1 (en) * | 2015-02-02 | 2016-08-11 | Wavelight Gmbh | Optical instrument for biomechanical diagnosis of eye disease |
| WO2017040959A1 (en) * | 2015-09-02 | 2017-03-09 | Seok-Hyun Yun | Performing a procedure based on monitored properties of biological tissues |
| CN108348151A (en) * | 2015-09-02 | 2018-07-31 | 通用医疗公司 | Monitoring characteristic implementation procedure based on biological tissue |
| WO2017112896A1 (en) * | 2015-12-22 | 2017-06-29 | Canon U.S. Life Sciences, Inc. | System and method of label-free cytometry based on brillouin light scattering |
| CN106017685A (en) * | 2016-05-13 | 2016-10-12 | 中国海洋大学 | Sweep-frequency spectrum measurement method based on virtual image phase array |
| CN107764741A (en) * | 2017-09-28 | 2018-03-06 | 南昌航空大学 | A kind of detection means for integrating stimulated Brillouin scattering and optical coherence elastogram |
| CN107907507A (en) * | 2017-09-28 | 2018-04-13 | 南昌航空大学 | A kind of lubricating oil elasticity modulus detection method based on Brillouin scattering spectrum |
| CN108007582A (en) * | 2017-11-28 | 2018-05-08 | 南昌航空大学 | A kind of method and device based on the detection of Rayleigh Brillouin scattering optical maser wavelength |
| CN108828553A (en) * | 2018-04-19 | 2018-11-16 | 南昌航空大学 | A kind of system and device of stimulated Brillouin scattering laser radar simulation deep-sea detecting |
| CN109875504A (en) * | 2019-01-15 | 2019-06-14 | 温州医科大学 | One kind being based on the viscoelastic method of jet-propelled optical coherence elastography non-invasive measurement cornea |
Non-Patent Citations (13)
| Title |
|---|
| Advances in applications of time-domain Brillouin scattering for nanoscale imaging;Vitalyi E. Gusev.et;《ARE》;20141231;第1-55页 * |
| An efficient method for discriminating four important edible oils based on stimulated Brillouin scattering spectroscopy;Jiulin Shi.et;《Analytical Methods》;20181231;第1-6页 * |
| Control of the carrier-envelope phases of a synchronously pumped femtosecond optical parametric oscillator and its applications;Barry J S Gale等;《Chinese Science Bulletin》;20080308(第05期);第4-13页 * |
| Low-noise Brillouin random fiber laser with a random grating-based resonator;YANPING XU.et;《Optics Letters》;20160715;第41卷(第14期);第3197-3200页 * |
| Mapping the subcellular mechanical properties of live cells in tissues with fluorescence emission–Brillouin imaging;Kareem Elsayad.et;《Science signaling》;20160705;第9卷(第435期);第1-33页 * |
| Stimulated Brillouin scattering in combination with visible absorption spectroscopy for authentication of vegetable oils and detection of olive oil adulteration;Jiulin Shi.et;《Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy》;20180817;第206卷;第320-327页 * |
| 一套高温高压原位拉曼散射、布里渊散射测量系统;贾茹等;《光散射学报》;20080915(第03期);第17-22页 * |
| 共焦布里渊显微镜轴向成像特性;钟昆等;《光学学报》;20161031;第36卷(第10期);第1018001-1-7页 * |
| 基于 F － P 的布里渊散射探测空中目标系统设计;何兴道等;《航空兵器》;20110831(第4期);第13-17页 * |
| 基于F-P的布里渊散射探测空中目标系统设计;何兴道等;《航空兵器》;20110815(第04期);第15-19页 * |
| 布里渊分布型光纤温度传感及信号处理技术研究;赵丽娟;《中国优秀硕士学位论文全文数据库》;20070115;第I140-35页 * |
| 环境温度宽范围变化对光纤布里渊频移的影响;赵丽娟;《物理学报》;20100915(第09期);第301-305页 * |
| 用F-P标准具和ICCD探测水中的布里渊散射信号;戴瑞等;《东北师大学报(自然科学版)》;20080920(第03期);第74-77页 * |
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