CN110420119A - A kind of new type acupuncture needle of optothermal material modification - Google Patents
A kind of new type acupuncture needle of optothermal material modification Download PDFInfo
- Publication number
- CN110420119A CN110420119A CN201910558308.0A CN201910558308A CN110420119A CN 110420119 A CN110420119 A CN 110420119A CN 201910558308 A CN201910558308 A CN 201910558308A CN 110420119 A CN110420119 A CN 110420119A
- Authority
- CN
- China
- Prior art keywords
- needle
- optothermal material
- new type
- needle body
- modification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000463 material Substances 0.000 title claims abstract description 45
- 230000004048 modification Effects 0.000 title claims abstract description 34
- 238000012986 modification Methods 0.000 title claims abstract description 34
- 238000001467 acupuncture Methods 0.000 title claims abstract description 26
- 239000000835 fiber Substances 0.000 claims abstract description 17
- 239000004814 polyurethane Substances 0.000 claims abstract description 17
- 229920002635 polyurethane Polymers 0.000 claims abstract description 17
- 230000005540 biological transmission Effects 0.000 claims abstract description 14
- 239000011701 zinc Substances 0.000 claims abstract description 14
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims abstract description 13
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 13
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 13
- 239000004065 semiconductor Substances 0.000 claims description 7
- 238000001179 sorption measurement Methods 0.000 claims description 7
- 230000008021 deposition Effects 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 230000008878 coupling Effects 0.000 claims description 4
- 238000005859 coupling reaction Methods 0.000 claims description 4
- 238000005886 esterification reaction Methods 0.000 claims description 4
- 239000013308 plastic optical fiber Substances 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 3
- 239000013307 optical fiber Substances 0.000 claims description 3
- 238000010792 warming Methods 0.000 abstract description 7
- 230000009471 action Effects 0.000 abstract description 5
- 238000007626 photothermal therapy Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 description 13
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 12
- 230000015572 biosynthetic process Effects 0.000 description 9
- 238000003786 synthesis reaction Methods 0.000 description 9
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 206010037660 Pyrexia Diseases 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 4
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 4
- 229910052709 silver Inorganic materials 0.000 description 4
- 239000004332 silver Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 229920001244 Poly(D,L-lactide) Polymers 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000011787 zinc oxide Substances 0.000 description 3
- 229940008841 1,6-hexamethylene diisocyanate Drugs 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 229960000935 dehydrated alcohol Drugs 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 101710134784 Agnoprotein Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 206010043189 Telangiectasia Diseases 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 238000004833 X-ray photoelectron spectroscopy Methods 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000001354 calcination Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229960004756 ethanol Drugs 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- 239000004312 hexamethylene tetramine Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000009056 telangiectasis Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
- A61H39/06—Devices for heating or cooling such points within cell-life limits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
- A61H39/08—Devices for applying needles to such points, i.e. for acupuncture ; Acupuncture needles or accessories therefor
- A61H39/086—Acupuncture needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/02—Characteristics of apparatus not provided for in the preceding codes heated or cooled
- A61H2201/0221—Mechanism for heating or cooling
Landscapes
- Health & Medical Sciences (AREA)
- Rehabilitation Therapy (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Finger-Pressure Massage (AREA)
Abstract
The invention discloses a kind of new type acupuncture needles of optothermal material modification, including needle body, the needle body includes shank and the needle handle and needle point for being separately positioned on its both ends, the needle handle top is connected with infrared generator by transmission fiber, the needle body surface modification has optothermal material, and the optothermal material is polyurethane or porous zinc bloom or gold nanorods or black phosphorus nanometer sheet.New type acupuncture needle of the invention can be warming up to 38.8-40.2 DEG C in 5-12 minutes, and it is metastable maintain this temperature, have the double action of traditional acupuncture and photo-thermal therapy.
Description
Technical field
The present invention relates to medical instruments field technical fields, and in particular to a kind of new type acupuncture needle of optothermal material modification.
Background technique
There are two types of form, one is needle thorns to combine with moxa-moxibustion for current warm acupuncture, and moxa item or other spices are wrapped up in
In on needle handle, intracorporal needle body is reached by the thermal energy for the ball burning that ends on needle handle and plays heat-therapeutic action, the disadvantage is that there are temperature
Not easy to control, stainless steel needle body is not easy to conduct heat, easy calcination skin；Another kind is the silver needle heating instrument by internal heat type to silver
Needle heating transmits heat using the high thermal conductivity of silver itself, to play heat-therapeutic action, the disadvantage is that silver needle material compared with
It is soft, it is difficult to enter and needs to treat the regions such as soft tissue, diameter is thicker, and fever range is big, it is easy to accidentally injure needle body normal surrounding tissue,
Technique is cumbersome, and cost is excessively high.
Summary of the invention
In view of the above shortcomings of the prior art, the present invention provides a kind of new type acupuncture needle of exothermal infrared heating, the acupuncture needle
It is modified using safe optothermal material, heating rapidly, and can maintain an opposite equilibrium temperature in vivo.
To achieve the above object, the invention provides the following technical scheme: a kind of new type acupuncture needle of optothermal material modification, packet
Needle body is included, the needle body includes shank and the needle handle and needle point for being separately positioned on its both ends, and the needle handle top passes through transmission light
Fibre is connected with infrared generator, and the needle body surface modification has optothermal material, and the optothermal material is porous zinc bloom or gold
Nanometer rods or black phosphorus nanometer sheet or polyurethane.
Preferably, the optothermal material arrives needle body surface by adsorption or surface deposition modification.
Preferably, the optothermal material is modified by modification by coupling or esterification reaction method to needle body surface.
Further, the infrared generator is semiconductor laser.
Further, the needle handle, the shank and the needle point are that solid integral type connects.
Further, the transmission fiber is one of plastic optical fiber, multimode fibre, glass optical fiber.
It is different from the prior art, beneficial effects of the present invention: (1) in vitro experiment, being emitted by infrared generator
The acupuncture wire surface of the invention that infrared-ray is irradiated to out, optothermal material respond infrared-ray heating fever, the photo-thermal material
Material is polyurethane or porous zinc bloom or gold nanorods or black phosphorus nanometer sheet, can be warming up to 38.8- in 5-12 minutes
40.2 DEG C, and metastable maintain this temperature；(2) small semiconductor infrared laser may be selected in photo-thermal generating device,
It is convenient for carrying, has the double action of traditional acupuncture Yu infrared photo-thermal acupuncture and moxibustion therapy.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is part A structural schematic diagram of the invention；
Fig. 3 is the near infrared camera temperature that needle body of the invention modifies upper porous zinc bloom；
Fig. 4 is the near infrared camera temperature that needle body of the invention modifies gold nanorods, black phosphorus nanometer sheet, polyurethane respectively；
Fig. 5 is the electron microscope of polyurethane of the invention；
Fig. 6 is the electron microscope of porous zinc bloom of the invention；
Fig. 7 is the electron microscope of gold nanorods of the invention；
Fig. 8 is the electron microscope of black phosphorus nanometer sheet of the invention；
Fig. 9 is polyurethane toxicity test figure in the embodiment of the present invention 1；
Figure 10 is porous zinc bloom toxicity test figure in the embodiment of the present invention 2；
In figure: 1. infrared generators；2. transmission fiber；3. needle handle；4. shank；5. optothermal material；6. needle point.
Specific embodiment
To be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, below with reference to
Specific embodiment, the present invention is further explained.
Embodiment 1: as shown in Fig. 1-2,3,6,10, a kind of new type acupuncture needle of optothermal material modification, including needle body, it is described
Needle body includes shank 4 and the needle handle 3 and needle point 6 for being separately positioned on its both ends, and 3 top of needle handle is connected by transmission fiber 2
There is infrared generator 1, the needle body surface modification has optothermal material 5, and the optothermal material 5 is porous zinc bloom.
Preferably, the porous zinc bloom arrives needle body surface by adsorption or surface deposition modification.
Further, the infrared generator 1 is semiconductor laser；The needle handle 3, the shank 4 and the needle
Point 6 connects for solid integral type；The transmission fiber 2 is plastic optical fiber.
In the present embodiment, porous zinc bloom synthesis step:
A. 1.4875g Zn (NO is weighed3)2·6H2O, 0.350465g hexamethylenetetramine is dissolved in 100ml deionized water, close
Envelope stirring 10min, 65 DEG C of water-bath 15min；
B. 0.14g sodium citrate, 0.1g hydroxypropyl methyl cellulose, 0.1g active carbon, 0.1g lignin is added, 85 DEG C water-soluble
10h；
C. dehydrated alcohol washs 2 times, is centrifuged 7000r/min 10min；Deionized water is washed 2 times, and 7000r/min is centrifuged
10min；
D.-80 DEG C of pre-freeze 6h is freeze-dried 12h to get porous zinc bloom.
Scanning electron microscope shooting has been carried out to the zinc oxide of synthesis, has been determined as the substance of vesicular texture, is then passed through
The inquiry experiment for having done infrared heating after adsorption or surface deposition modification to needle body surface to it, finds the porous oxidation
Zinc material responds infrared-ray heating fever, and 38.8-40.2 DEG C, and metastable maintenance can be warming up in 9-12 minutes
In this temperature, in order to judge that can the zinc oxide be used for biomedical applications, and cytotoxicity compatibility experiments are done to it,
As a result, it has been found that the biocompatibility of the zinc oxide is fine.
Embodiment 2: as shown in Fig. 1-2,4,7, a kind of new type acupuncture needle of optothermal material modification, including needle body, the needle
Body includes shank 4 and the needle handle 3 and needle point 6 for being separately positioned on its both ends, and 3 top of needle handle is connected with by transmission fiber 2
Infrared generator 1, the needle body surface modification have optothermal material 5, and the optothermal material 5 is gold nanorods.
Preferably, the gold nanorods arrive needle body surface by adsorption or surface deposition modification.
Further, the infrared generator 1 is semiconductor laser；The needle handle 3, the shank 4 and the needle
Point 6 connects for solid integral type；The transmission fiber 2 is multimode fibre.
In the present embodiment, the synthesis step of gold nanorods:
A. by the HAuCl of the 0.2M CTAB solution of 5mL and 2.5mL deionized water and the 0.001M of 2.5mL4Under constant stirring
Mixing；
B. the ice-cold sodium borohydride of 0.01M of 0.6mL is added dropwise with continuous stirring until forming brown yellow solution；
C. at 28 DEG C after agitating solution 2 minutes, seed solution is made, seed solution must use between 2 to 5 hours；
D., the 0.2M CTAB of 50mL is added to the 0.01M AgNO of 1mL at 28 DEG C3In solution, then after mild mixing by
It is added dropwise to the 0.001M HAuCl of 50mL4With the 0.1M ascorbic acid of 0.8mL, until growth solution color from buff becomes nothing
Color obtains growth solution；
E. finally, 200 μ L seed solutions are added, growth solution is kept constant at 28 DEG C and is stirred overnight, by being centrifuged 11000r/
Min collection prepares gold nanorods 30 minutes.
Scanning electron microscope shooting has been carried out to the gold nanorods of synthesis, has been determined as the substance of club shaped structure, is then passed through
The inquiry experiment for having done infrared heating after adsorption or surface deposition modification to needle body surface to it, finds the gold nanorods
The heating fever of material response infrared-ray, can be warming up to 38.8-40.2 DEG C, and metastable maintain in 5-12 minutes
This temperature.
Embodiment 3: as shown in Fig. 1-2,4,8, a kind of new type acupuncture needle of optothermal material modification, including needle body, the needle
Body includes shank 4 and the needle handle 3 and needle point 6 for being separately positioned on its both ends, and 3 top of needle handle is connected with by transmission fiber 2
Infrared generator 1, the needle body surface modification have optothermal material 5, and the optothermal material 5 is black phosphorus nanometer sheet.
Preferably, the black phosphorus nanometer sheet is modified by modification by coupling or esterification reaction method to needle body surface.
Further, the infrared generator 1 is semiconductor laser；The needle handle 3, the shank 4 and the needle
Point 6 connects for solid integral type；The transmission fiber 2 is glass optical fiber.
In the present embodiment, the synthesis step of the black phosphorus nanometer sheet:
A. the BP powder of 20mg is dissolved in the saturation NaOH solution of 50ml n-methyl-2-pyrrolidone；
B. the solution mixed is placed in ice bath and impregnates 6h, and half an hour changes an ice cube；
C. the brown suspension collected is placed in a centrifuge 4000r/min, and centrifugation 8min takes out remaining unstripped
Grain, and collect supernatant fluid；
D. supernatant is stored in minus 20 DEG C of refrigerators, black phosphorus nanometer sheet is made.
Scanning electron microscope shooting has been carried out to the black phosphorus nanometer sheet of synthesis, has been determined as the substance of laminated structure, is then led to
Modification by coupling or esterification reaction method modification are crossed to the inquiry experiment for having done infrared heating behind needle body surface to it, finds the black phosphorus
The heating fever of nanometer sheet material response infrared-ray, can be warming up to 38.8-40.2 DEG C, and metastable in 5-12 minutes
Maintain this temperature.
Embodiment 4: as shown in Fig. 1-2,4,5,9, a kind of new type acupuncture needle of optothermal material modification, including needle body, it is described
Needle body includes shank 4 and the needle handle 3 and needle point 6 for being separately positioned on its both ends, and 3 top of needle handle is connected by transmission fiber 2
There is infrared generator 1, the needle body surface modification has optothermal material 5, and the optothermal material 5 is polyurethane.
Preferably, the polyurethane is modified by adsorption to needle body surface.
Further, the infrared generator 1 is semiconductor laser；The needle handle 3, the shank 4 and the needle
Point 6 connects for solid integral type；The transmission fiber 2 is plastic optical fiber.
In the present embodiment, polyurethane synthesis step:
A. in stannous octoate (Sn (Oct)2) initiator and piperazine (PP) is used as to be used as in the presence of coinitiator, under vacuum,
24 hours at 150 DEG C, by D, the ring-opening polymerisation of L- lactide synthesizes PDLLA glycol；
B, resulting polymers are co-precipitated purifying in chloroform and dehydrated alcohol at room temperature, and the polymer of purifying is true at room temperature
Sky is 48 hours dry；
C, by polyester-diol (PDLLA), 1,6- hexamethylene diisocyanate (HDI), stannous octoate (Sn (Oct)2) and it is anhydrous
Toluene is added in the 250mL three neck round bottom equipped with magnetic stirring apparatus, obtains prepolymer after reacting 3 hours at 75 DEG C；
D, the piperazine (PP) being dissolved in isopropanol is slowly added in reaction system, and chain extension 2 hours, pass through first at 30 DEG C
The co-precipitation of benzene/ethyl alcohol purifies polyurethane, and is dried in vacuo 48 hours at room temperature.
The polyester-diol (PDLLA): 1,6- hexamethylene diisocyanate (HDI): the crosslinking of piperazine (PP), which matches, is
1:1.5:0.5。
Scanning electron microscope shooting has been carried out to the polyurethane of synthesis, has been determined as the substance for having cavernous structure, it is rear again to synthesis
Intermediate polyester-diol and polyurethane have carried out infrared Fourier, nuclear magnetic resonance, X-ray diffraction, x-ray photoelectron spectroscopy, drawing
The test such as graceful spectrum, it was demonstrated that by adjusting proportion be crosslinked, it was found that it have in structure with conventional polyurethanes it is different, together
When it there are also certain viscosity, then smeared the inquiry experiment for having done infrared heating after being adsorbed in needle body surface to it, send out
Now the polyurethane temperature rise effect is especially good, and temperature, which rises, to be stablized, and can be warming up to 38.8-40.2 DEG C in 8-10 minutes.In order to
Judge that can the polyurethane be used for biomedical applications, and done cytotoxicity compatibility experiments to it, as a result, it has been found that the poly- ammonia
The biocompatibility of ester is fine.
Working principle: the present invention converts electrical energy into luminous energy and generates infrared light by external infrared generator 1
Beam, light beam are irradiated on the optothermal material 5 of needle body surface modification of the invention, and the optothermal material 5 is polyurethane or porous oxygen
Violent resonance effects can be generated with near-infrared light beam by changing zinc or gold nanorods or black phosphorus nanometer sheet, these optothermal materials 5,
It can be warming up to 38.8-40.2 DEG C in 5-12 minutes, and maintain a metastable temperature, it thus can be in maximum
Degree on promote the heating property of acupuncture needle, improve the permeability in thermal energy portion within the organization, persistence and stability, the present invention
New type acupuncture needle thermal energy action intensity, not only facilitate the telangiectasis of textura epidermoidea, promote blood circulation, also
The metabolism between deep tissues may be strengthened, the power of regeneration of muscle and fascia is improved, improve the immunocompetence of body, adjusted
The exaltation state for saving spirit, to play better medical health effect than traditional acupuncture technology.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (6)
1. a kind of new type acupuncture needle of optothermal material modification, including needle body, the needle body include shank (4) and are separately positioned on it
The needle handle (3) and needle point (6) at both ends, it is characterised in that: needle handle (3) top is connected with infrared hair by transmission fiber (2)
Generating apparatus (1), the needle body surface modification have optothermal material (5), and the optothermal material (5) is porous zinc bloom or gold nanorods
Or black phosphorus nanometer sheet or polyurethane.
2. a kind of new type acupuncture needle of optothermal material modification according to claim 1, it is characterised in that: the optothermal material
(5) needle body surface is arrived by adsorption or surface deposition modification.
3. a kind of new type acupuncture needle of optothermal material modification according to claim 1, it is characterised in that: the optothermal material
(5) it is modified by modification by coupling or esterification reaction method to needle body surface.
4. a kind of new type acupuncture needle of optothermal material modification according to claim 1, it is characterised in that: the infrared generation
Device (1) is semiconductor laser.
5. a kind of new type acupuncture needle of optothermal material modification according to claim 1, it is characterised in that: the needle handle (3),
The shank (4) is that solid integral type connects with the needle point (6).
6. a kind of new type acupuncture needle of optothermal material modification according to claim 1, it is characterised in that: the transmission fiber
It (2) is one of plastic optical fiber, multimode fibre, glass optical fiber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910558308.0A CN110420119A (en) | 2019-06-25 | 2019-06-25 | A kind of new type acupuncture needle of optothermal material modification |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910558308.0A CN110420119A (en) | 2019-06-25 | 2019-06-25 | A kind of new type acupuncture needle of optothermal material modification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110420119A true CN110420119A (en) | 2019-11-08 |
Family
ID=68408753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910558308.0A Pending CN110420119A (en) | 2019-06-25 | 2019-06-25 | A kind of new type acupuncture needle of optothermal material modification |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110420119A (en) |
-
2019
- 2019-06-25 CN CN201910558308.0A patent/CN110420119A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105535971B (en) | A kind of black phosphorus nano particle and its preparation method and application with biocompatibility | |
| CN108434462B (en) | Multifunctional nano diagnosis and treatment agent with mesoporous polydopamine loaded carbonyl manganese and preparation method and application thereof | |
| Chen et al. | Near-IR-triggered photothermal/photodynamic dual-modality therapy system via chitosan hybrid nanospheres | |
| CN111375060B (en) | Composite fiber with pH and near-infrared light response drug release and preparation method and application thereof | |
| CN101375790A (en) | Inductor applied to light power diagnosis and therapy | |
| JP2017515530A (en) | System and method for therapeutic management of cough | |
| Yan et al. | Second Near‐Infrared Plasmonic Nanomaterials for Photoacoustic Imaging and Photothermal Therapy | |
| CN108853059A (en) | A kind of polypyrrole-polyvinylpyrrolidone nano particle and its preparation method and application | |
| CN110339357A (en) | Copper ion doped carbon dots, preparation and its application as photosensitizer for photodynamic therapy | |
| CN105813461A (en) | A modified surface capable of having bacteriostatic and bactericide activity, the method for obtaining it and use thereof | |
| CN111228484B (en) | Application of xonotlite and composite biological material containing xonotlite | |
| CN109528352A (en) | A kind of shape-memory polymer carries medicine intestinal stent and preparation method thereof | |
| CN111741794A (en) | Photodynamic therapy device, system and method | |
| Sadeghi et al. | Brainy biomaterials: Latest advances in smart biomaterials to develop the next generation of neural interfaces | |
| MacNeill et al. | A comparative study of the photothermal efficiency of electrically conducting poly (3, 4-ethylenedioxythiophene)-based nanomaterials with cancer cells | |
| CN110538151A (en) | Near-infrared light response nano liposome, preparation method thereof and application thereof in tumor cooperative treatment | |
| CN110420119A (en) | A kind of new type acupuncture needle of optothermal material modification | |
| CN106310263B (en) | A kind of assembly system and preparation method thereof of PEGMa modification MoOx and temperature sensitive PNIPAM microgel | |
| CN104258424A (en) | Compound nano diagnosis and treatment preparation and preparation method thereof | |
| Fu et al. | Near-Infrared Rechargeable Persistent Luminescence Nanoparticles for Biomedical Implants In Vivo Noninvasive Bioimaging | |
| CN114292639B (en) | Multifunctional nano material based on aggregation-induced emission and MXenes, preparation method and application | |
| CN111286326A (en) | Preparation method and application of silicate long-afterglow probe | |
| CN100435763C (en) | Tumor whole body thermotherapy device for realizing intravascular heating by combining heat seeds and intravascular stent | |
| CN114949623A (en) | Wireless battery-free photoacoustic power hybrid treatment pill and preparation method and application thereof | |
| KR102182630B1 (en) | Eco-friendly smart photosensitizers and photobiomodulation of stem cell therapy agent using the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20191108 |
|
| WD01 | Invention patent application deemed withdrawn after publication |