CN110420119A - A kind of new type acupuncture needle of optothermal material modification - Google Patents
A kind of new type acupuncture needle of optothermal material modification Download PDFInfo
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- CN110420119A CN110420119A CN201910558308.0A CN201910558308A CN110420119A CN 110420119 A CN110420119 A CN 110420119A CN 201910558308 A CN201910558308 A CN 201910558308A CN 110420119 A CN110420119 A CN 110420119A
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- needle
- optothermal material
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- needle body
- modification
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
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- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
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- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
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- 235000010323 ascorbic acid Nutrition 0.000 description 1
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- 239000011668 ascorbic acid Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
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- 229910052737 gold Inorganic materials 0.000 description 1
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- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- 239000004312 hexamethylene tetramine Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
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- 238000011069 regeneration method Methods 0.000 description 1
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- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
- A61H39/06—Devices for heating or cooling such points within cell-life limits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
- A61H39/08—Devices for applying needles to such points, i.e. for acupuncture ; Acupuncture needles or accessories therefor
- A61H39/086—Acupuncture needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/02—Characteristics of apparatus not provided for in the preceding codes heated or cooled
- A61H2201/0221—Mechanism for heating or cooling
Landscapes
- Health & Medical Sciences (AREA)
- Rehabilitation Therapy (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Finger-Pressure Massage (AREA)
Abstract
The invention discloses a kind of new type acupuncture needles of optothermal material modification, including needle body, the needle body includes shank and the needle handle and needle point for being separately positioned on its both ends, the needle handle top is connected with infrared generator by transmission fiber, the needle body surface modification has optothermal material, and the optothermal material is polyurethane or porous zinc bloom or gold nanorods or black phosphorus nanometer sheet.New type acupuncture needle of the invention can be warming up to 38.8-40.2 DEG C in 5-12 minutes, and it is metastable maintain this temperature, have the double action of traditional acupuncture and photo-thermal therapy.
Description
Technical field
The present invention relates to medical instruments field technical fields, and in particular to a kind of new type acupuncture needle of optothermal material modification.
Background technique
There are two types of form, one is needle thorns to combine with moxa-moxibustion for current warm acupuncture, and moxa item or other spices are wrapped up in
In on needle handle, intracorporal needle body is reached by the thermal energy for the ball burning that ends on needle handle and plays heat-therapeutic action, the disadvantage is that there are temperature
Not easy to control, stainless steel needle body is not easy to conduct heat, easy calcination skin；Another kind is the silver needle heating instrument by internal heat type to silver
Needle heating transmits heat using the high thermal conductivity of silver itself, to play heat-therapeutic action, the disadvantage is that silver needle material compared with
It is soft, it is difficult to enter and needs to treat the regions such as soft tissue, diameter is thicker, and fever range is big, it is easy to accidentally injure needle body normal surrounding tissue,
Technique is cumbersome, and cost is excessively high.
Summary of the invention
In view of the above shortcomings of the prior art, the present invention provides a kind of new type acupuncture needle of exothermal infrared heating, the acupuncture needle
It is modified using safe optothermal material, heating rapidly, and can maintain an opposite equilibrium temperature in vivo.
To achieve the above object, the invention provides the following technical scheme: a kind of new type acupuncture needle of optothermal material modification, packet
Needle body is included, the needle body includes shank and the needle handle and needle point for being separately positioned on its both ends, and the needle handle top passes through transmission light
Fibre is connected with infrared generator, and the needle body surface modification has optothermal material, and the optothermal material is porous zinc bloom or gold
Nanometer rods or black phosphorus nanometer sheet or polyurethane.
Preferably, the optothermal material arrives needle body surface by adsorption or surface deposition modification.
Preferably, the optothermal material is modified by modification by coupling or esterification reaction method to needle body surface.
Further, the infrared generator is semiconductor laser.
Further, the needle handle, the shank and the needle point are that solid integral type connects.
Further, the transmission fiber is one of plastic optical fiber, multimode fibre, glass optical fiber.
It is different from the prior art, beneficial effects of the present invention: (1) in vitro experiment, being emitted by infrared generator
The acupuncture wire surface of the invention that infrared-ray is irradiated to out, optothermal material respond infrared-ray heating fever, the photo-thermal material
Material is polyurethane or porous zinc bloom or gold nanorods or black phosphorus nanometer sheet, can be warming up to 38.8- in 5-12 minutes
40.2 DEG C, and metastable maintain this temperature；(2) small semiconductor infrared laser may be selected in photo-thermal generating device,
It is convenient for carrying, has the double action of traditional acupuncture Yu infrared photo-thermal acupuncture and moxibustion therapy.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is part A structural schematic diagram of the invention；
Fig. 3 is the near infrared camera temperature that needle body of the invention modifies upper porous zinc bloom；
Fig. 4 is the near infrared camera temperature that needle body of the invention modifies gold nanorods, black phosphorus nanometer sheet, polyurethane respectively；
Fig. 5 is the electron microscope of polyurethane of the invention；
Fig. 6 is the electron microscope of porous zinc bloom of the invention；
Fig. 7 is the electron microscope of gold nanorods of the invention；
Fig. 8 is the electron microscope of black phosphorus nanometer sheet of the invention；
Fig. 9 is polyurethane toxicity test figure in the embodiment of the present invention 1；
Figure 10 is porous zinc bloom toxicity test figure in the embodiment of the present invention 2；
In figure: 1. infrared generators；2. transmission fiber；3. needle handle；4. shank；5. optothermal material；6. needle point.
Specific embodiment
To be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, below with reference to
Specific embodiment, the present invention is further explained.
Embodiment 1: as shown in Fig. 1-2,3,6,10, a kind of new type acupuncture needle of optothermal material modification, including needle body, it is described
Needle body includes shank 4 and the needle handle 3 and needle point 6 for being separately positioned on its both ends, and 3 top of needle handle is connected by transmission fiber 2
There is infrared generator 1, the needle body surface modification has optothermal material 5, and the optothermal material 5 is porous zinc bloom.
Preferably, the porous zinc bloom arrives needle body surface by adsorption or surface deposition modification.
Further, the infrared generator 1 is semiconductor laser；The needle handle 3, the shank 4 and the needle
Point 6 connects for solid integral type；The transmission fiber 2 is plastic optical fiber.
In the present embodiment, porous zinc bloom synthesis step:
A. 1.4875g Zn (NO is weighed3)2·6H2O, 0.350465g hexamethylenetetramine is dissolved in 100ml deionized water, close
Envelope stirring 10min, 65 DEG C of water-bath 15min；
B. 0.14g sodium citrate, 0.1g hydroxypropyl methyl cellulose, 0.1g active carbon, 0.1g lignin is added, 85 DEG C water-soluble
10h；
C. dehydrated alcohol washs 2 times, is centrifuged 7000r/min 10min；Deionized water is washed 2 times, and 7000r/min is centrifuged
10min；
D.-80 DEG C of pre-freeze 6h is freeze-dried 12h to get porous zinc bloom.
Scanning electron microscope shooting has been carried out to the zinc oxide of synthesis, has been determined as the substance of vesicular texture, is then passed through
The inquiry experiment for having done infrared heating after adsorption or surface deposition modification to needle body surface to it, finds the porous oxidation
Zinc material responds infrared-ray heating fever, and 38.8-40.2 DEG C, and metastable maintenance can be warming up in 9-12 minutes
In this temperature, in order to judge that can the zinc oxide be used for biomedical applications, and cytotoxicity compatibility experiments are done to it,
As a result, it has been found that the biocompatibility of the zinc oxide is fine.
Embodiment 2: as shown in Fig. 1-2,4,7, a kind of new type acupuncture needle of optothermal material modification, including needle body, the needle
Body includes shank 4 and the needle handle 3 and needle point 6 for being separately positioned on its both ends, and 3 top of needle handle is connected with by transmission fiber 2
Infrared generator 1, the needle body surface modification have optothermal material 5, and the optothermal material 5 is gold nanorods.
Preferably, the gold nanorods arrive needle body surface by adsorption or surface deposition modification.
Further, the infrared generator 1 is semiconductor laser；The needle handle 3, the shank 4 and the needle
Point 6 connects for solid integral type；The transmission fiber 2 is multimode fibre.
In the present embodiment, the synthesis step of gold nanorods:
A. by the HAuCl of the 0.2M CTAB solution of 5mL and 2.5mL deionized water and the 0.001M of 2.5mL4Under constant stirring
Mixing；
B. the ice-cold sodium borohydride of 0.01M of 0.6mL is added dropwise with continuous stirring until forming brown yellow solution；
C. at 28 DEG C after agitating solution 2 minutes, seed solution is made, seed solution must use between 2 to 5 hours；
D., the 0.2M CTAB of 50mL is added to the 0.01M AgNO of 1mL at 28 DEG C3In solution, then after mild mixing by
It is added dropwise to the 0.001M HAuCl of 50mL4With the 0.1M ascorbic acid of 0.8mL, until growth solution color from buff becomes nothing
Color obtains growth solution；
E. finally, 200 μ L seed solutions are added, growth solution is kept constant at 28 DEG C and is stirred overnight, by being centrifuged 11000r/
Min collection prepares gold nanorods 30 minutes.
Scanning electron microscope shooting has been carried out to the gold nanorods of synthesis, has been determined as the substance of club shaped structure, is then passed through
The inquiry experiment for having done infrared heating after adsorption or surface deposition modification to needle body surface to it, finds the gold nanorods
The heating fever of material response infrared-ray, can be warming up to 38.8-40.2 DEG C, and metastable maintain in 5-12 minutes
This temperature.
Embodiment 3: as shown in Fig. 1-2,4,8, a kind of new type acupuncture needle of optothermal material modification, including needle body, the needle
Body includes shank 4 and the needle handle 3 and needle point 6 for being separately positioned on its both ends, and 3 top of needle handle is connected with by transmission fiber 2
Infrared generator 1, the needle body surface modification have optothermal material 5, and the optothermal material 5 is black phosphorus nanometer sheet.
Preferably, the black phosphorus nanometer sheet is modified by modification by coupling or esterification reaction method to needle body surface.
Further, the infrared generator 1 is semiconductor laser；The needle handle 3, the shank 4 and the needle
Point 6 connects for solid integral type；The transmission fiber 2 is glass optical fiber.
In the present embodiment, the synthesis step of the black phosphorus nanometer sheet:
A. the BP powder of 20mg is dissolved in the saturation NaOH solution of 50ml n-methyl-2-pyrrolidone；
B. the solution mixed is placed in ice bath and impregnates 6h, and half an hour changes an ice cube；
C. the brown suspension collected is placed in a centrifuge 4000r/min, and centrifugation 8min takes out remaining unstripped
Grain, and collect supernatant fluid；
D. supernatant is stored in minus 20 DEG C of refrigerators, black phosphorus nanometer sheet is made.
Scanning electron microscope shooting has been carried out to the black phosphorus nanometer sheet of synthesis, has been determined as the substance of laminated structure, is then led to
Modification by coupling or esterification reaction method modification are crossed to the inquiry experiment for having done infrared heating behind needle body surface to it, finds the black phosphorus
The heating fever of nanometer sheet material response infrared-ray, can be warming up to 38.8-40.2 DEG C, and metastable in 5-12 minutes
Maintain this temperature.
Embodiment 4: as shown in Fig. 1-2,4,5,9, a kind of new type acupuncture needle of optothermal material modification, including needle body, it is described
Needle body includes shank 4 and the needle handle 3 and needle point 6 for being separately positioned on its both ends, and 3 top of needle handle is connected by transmission fiber 2
There is infrared generator 1, the needle body surface modification has optothermal material 5, and the optothermal material 5 is polyurethane.
Preferably, the polyurethane is modified by adsorption to needle body surface.
Further, the infrared generator 1 is semiconductor laser；The needle handle 3, the shank 4 and the needle
Point 6 connects for solid integral type；The transmission fiber 2 is plastic optical fiber.
In the present embodiment, polyurethane synthesis step:
A. in stannous octoate (Sn (Oct)2) initiator and piperazine (PP) is used as to be used as in the presence of coinitiator, under vacuum,
24 hours at 150 DEG C, by D, the ring-opening polymerisation of L- lactide synthesizes PDLLA glycol；
B, resulting polymers are co-precipitated purifying in chloroform and dehydrated alcohol at room temperature, and the polymer of purifying is true at room temperature
Sky is 48 hours dry；
C, by polyester-diol (PDLLA), 1,6- hexamethylene diisocyanate (HDI), stannous octoate (Sn (Oct)2) and it is anhydrous
Toluene is added in the 250mL three neck round bottom equipped with magnetic stirring apparatus, obtains prepolymer after reacting 3 hours at 75 DEG C；
D, the piperazine (PP) being dissolved in isopropanol is slowly added in reaction system, and chain extension 2 hours, pass through first at 30 DEG C
The co-precipitation of benzene/ethyl alcohol purifies polyurethane, and is dried in vacuo 48 hours at room temperature.
The polyester-diol (PDLLA): 1,6- hexamethylene diisocyanate (HDI): the crosslinking of piperazine (PP), which matches, is
1:1.5:0.5。
Scanning electron microscope shooting has been carried out to the polyurethane of synthesis, has been determined as the substance for having cavernous structure, it is rear again to synthesis
Intermediate polyester-diol and polyurethane have carried out infrared Fourier, nuclear magnetic resonance, X-ray diffraction, x-ray photoelectron spectroscopy, drawing
The test such as graceful spectrum, it was demonstrated that by adjusting proportion be crosslinked, it was found that it have in structure with conventional polyurethanes it is different, together
When it there are also certain viscosity, then smeared the inquiry experiment for having done infrared heating after being adsorbed in needle body surface to it, send out
Now the polyurethane temperature rise effect is especially good, and temperature, which rises, to be stablized, and can be warming up to 38.8-40.2 DEG C in 8-10 minutes.In order to
Judge that can the polyurethane be used for biomedical applications, and done cytotoxicity compatibility experiments to it, as a result, it has been found that the poly- ammonia
The biocompatibility of ester is fine.
Working principle: the present invention converts electrical energy into luminous energy and generates infrared light by external infrared generator 1
Beam, light beam are irradiated on the optothermal material 5 of needle body surface modification of the invention, and the optothermal material 5 is polyurethane or porous oxygen
Violent resonance effects can be generated with near-infrared light beam by changing zinc or gold nanorods or black phosphorus nanometer sheet, these optothermal materials 5,
It can be warming up to 38.8-40.2 DEG C in 5-12 minutes, and maintain a metastable temperature, it thus can be in maximum
Degree on promote the heating property of acupuncture needle, improve the permeability in thermal energy portion within the organization, persistence and stability, the present invention
New type acupuncture needle thermal energy action intensity, not only facilitate the telangiectasis of textura epidermoidea, promote blood circulation, also
The metabolism between deep tissues may be strengthened, the power of regeneration of muscle and fascia is improved, improve the immunocompetence of body, adjusted
The exaltation state for saving spirit, to play better medical health effect than traditional acupuncture technology.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (6)
1. a kind of new type acupuncture needle of optothermal material modification, including needle body, the needle body include shank (4) and are separately positioned on it
The needle handle (3) and needle point (6) at both ends, it is characterised in that: needle handle (3) top is connected with infrared hair by transmission fiber (2)
Generating apparatus (1), the needle body surface modification have optothermal material (5), and the optothermal material (5) is porous zinc bloom or gold nanorods
Or black phosphorus nanometer sheet or polyurethane.
2. a kind of new type acupuncture needle of optothermal material modification according to claim 1, it is characterised in that: the optothermal material
(5) needle body surface is arrived by adsorption or surface deposition modification.
3. a kind of new type acupuncture needle of optothermal material modification according to claim 1, it is characterised in that: the optothermal material
(5) it is modified by modification by coupling or esterification reaction method to needle body surface.
4. a kind of new type acupuncture needle of optothermal material modification according to claim 1, it is characterised in that: the infrared generation
Device (1) is semiconductor laser.
5. a kind of new type acupuncture needle of optothermal material modification according to claim 1, it is characterised in that: the needle handle (3),
The shank (4) is that solid integral type connects with the needle point (6).
6. a kind of new type acupuncture needle of optothermal material modification according to claim 1, it is characterised in that: the transmission fiber
It (2) is one of plastic optical fiber, multimode fibre, glass optical fiber.
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| CN201910558308.0A CN110420119A (en) | 2019-06-25 | 2019-06-25 | A kind of new type acupuncture needle of optothermal material modification |
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Application publication date: 20191108 |