CN110404118A - Bone defect repair support and construction method, preparation method, computer readable storage medium, equipment - Google Patents
Bone defect repair support and construction method, preparation method, computer readable storage medium, equipment Download PDFInfo
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- CN110404118A CN110404118A CN201910759966.6A CN201910759966A CN110404118A CN 110404118 A CN110404118 A CN 110404118A CN 201910759966 A CN201910759966 A CN 201910759966A CN 110404118 A CN110404118 A CN 110404118A
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 204
- 230000007547 defect Effects 0.000 title claims abstract description 161
- 230000008439 repair process Effects 0.000 title claims abstract description 119
- 238000010276 construction Methods 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000002344 surface layer Substances 0.000 claims abstract description 45
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- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical group [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims abstract description 34
- 229910001362 Ta alloys Inorganic materials 0.000 claims abstract description 25
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
- B22F3/10—Sintering only
- B22F3/11—Making porous workpieces or articles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F5/00—Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
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- G—PHYSICS
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- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T17/00—Three dimensional [3D] modelling, e.g. data description of 3D objects
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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Abstract
The present invention provides a kind of bone defect repair support and construction method, preparation method, computer readable storage medium, equipment, the bone defect repair support includes bone defect repair support ontology and fusion surface layer, the bone defect repair support ontology merges surface layer equipped with described with the contact surface of sclerotin, the bone defect repair support ontology has hollow cavity, the fusion surface layer is porous structure, and the material of the bone defect repair support is tantalum metal or tantalum alloy.Bone defect repair support of the invention is effectively prevented from stress-shielding effect, reduces the risk of secondary fracture；Tantalum metal or tantalum alloy are close biological metal, itself does not have any toxic side effect for human body, have outstanding implants biology performance, have the function of promoting bone defect healing；The porous structure of tantalum metal or tantalum alloy is conducive to newborn Bone Ingrowth material internal, obtains good Integrated implant effect.
Description
Technical field
The invention belongs to Bone Defect Repari technical fields, more particularly to a kind of bone defect repair support and construction method, preparation
Method, computer readable storage medium, equipment.
Background technique
Bone defect is a kind of common clinical disease, infection, tumour, wound, and operation wound clearing after osteomyelitis etc. is various congenital
Property disease is the main reason for leading to bone defect.It will receive according to the stability of the range size bone of bone defect different degrees of
It influences, the bone for losing stability is obviously poor to the tolerance of external shock, thus has under the action of slight external force
Secondary fracture may occur.In addition, due to the part sclerotin lost, the union of sufferer is lain up and regular time
Also can significantly extend, to bring a series of complication.In order to repair the stability of bone and avoid the occurrence of secondary fracture, need
Bone defect is repaired in time.
Currently, clinically the method for repairing bone defect has self or allogenic bone transplantation, artificial bone substitution etc..It is self or
The defect of allogenic bone transplantation various degrees: 1) autologous bone transplanting can additionally increase operation wound and operating time for
The form of the limited bone graft in bone source, size etc. are not easy to meet the requirements, and the area Qu Gu is likely to occur the complication such as infection, pain.
2) the disadvantages of homogeneous allogenic bone transplantation may cause the propagation of blood borne disease and cause immune response interference knitting；In addition same
Kind of allograph bone only have bone conduction effect and without bone inductive effect.Post-transplantation union may be relatively slow.Therefore, clinical mesh
Preceding one kind of being badly in need of perfect can replace self or homogeneous allogenic bone artificial bone impairment renovation material.
Summary of the invention
Following problems clinically are primarily present for the artificial bone sub of bone defect healing at present: 1) implants and bone
Elasticity modulus mismatches, and stress shielding phenomenon is easy to produce after implantation, and the risk of secondary fracture while bone loss is accelerated to increase
Add；2) implants do not have the biological function for promoting union, stable environment needed for only providing union；3) due to
The limitation of conventional machining process causes the form of filler and defect to mismatch, and will cause and wears and be possible to again result in bone
Folding；4) porosity of porous material and pore shape effect of irregular Integrated implant effect of traditional handicraft processing at present.For with
Present on problem, the present invention provides a kind of bone defect repair support, and the bone defect repair support includes bone defect healing branch
Frame ontology and fusion surface layer, the bone defect repair support ontology merge surface layer, the bone equipped with described with the contact surface of sclerotin
Defect repair rack body has hollow cavity, and the fusion surface layer is porous structure, the material of the bone defect repair support
For tantalum metal or tantalum alloy.Elasticity modulus (the 186- of tantalum metal or tantalum alloy in bone defect repair support of the invention
191Gpa), similar with stainless steel (186GPa), be higher than titanium alloy (110GPa), but pass through porous processing tantalum metal or
The elasticity modulus of tantalum alloy bracket then closer and skeleton compared with titanium alloy.Therefore, material is filled as bone defect
Stress-shielding effect can be effectively avoided in material, reduces the risk of secondary fracture；Tantalum metal or tantalum alloy are close biological metal,
Itself there is no any toxic side effect for human body, there is outstanding implants biology performance, has and promote bone defect healing
Effect；The porous structure of tantalum metal or tantalum alloy is conducive to newborn Bone Ingrowth material internal, obtains good Integrated implant effect, from
And improve the repairing quality of bone defect.
In order to achieve the above objects and other related objects, the invention adopts the following technical scheme:
First aspect present invention provides a kind of bone defect repair support, and the bone defect repair support includes bone defect healing
Rack body and fusion surface layer, the bone defect repair support ontology and the contact surface of sclerotin be equipped with it is described merge surface layer, it is described
Bone defect repair support ontology has hollow cavity, and the fusion surface layer is porous structure, the material of the bone defect repair support
Material is tantalum metal or tantalum alloy.
Second aspect of the present invention provides the construction method of above-mentioned bone defect repair support model, includes the following steps:
1) bone threedimensional model is constructed；
2) excision extension is determined, the bone threedimensional model after simulation is cut off on the bone threedimensional model, and with
Cut-out is as initial bone defect repair support model；
3) it regard the excision face on initial bone defect repair support model as contact surface, simultaneously by the inward-facing stretching of the contact
Layering constructs several fusion surface units, and constructs several through-holes on each fusion surface units and obtain fusion surface layer mould
Type, using the remainder after the initial bone defect repair support model removal fusion surface layer model as initial bone defect healing
Rack body model；
4) hollow cavity is constructed in the initial bone defect repair support ontology model that step 3) obtains, obtains bone defect healing
Rack body model, to obtain the bone defect repair support model.
Third aspect present invention provides the preparation method of above-mentioned bone defect repair support, and the preparation method includes: basis
The construction method building of above-mentioned bone defect repair support model obtains bone defect repair support model, prepares bone defect healing branch
Frame.
Fourth aspect present invention provides a kind of computer readable storage medium, is stored thereon with computer program, the journey
The step of construction method of above-mentioned bone defect repair support model is realized when sequence is executed by processor or above-mentioned bone defect healing branch
The step of preparation method of frame.
Fifth aspect present invention provides a kind of equipment, comprising: processor and memory, the memory are calculated for storing
Machine program, the processor is used to execute the computer program of the memory storage, so that the equipment executes above-mentioned bone and lacks
The step of preparation method of the step of damaging the construction method of recovery support model or above-mentioned bone defect repair support.
As described above, the present invention one of at least has the advantages that:
1) elasticity modulus of porous tantalum metal or tantalum alloy and skeleton perfect matching have good biocompatibility,
The risk of secondary fracture can be effectively reduced.
2) bioactivity of tantalum metal or tantalum alloy have the function of promote Bone Defect Repari, be conducive to bone defect earlier more
It closes, will appear pressure sore, hypostatic pneumonia, the severe complications such as deep vein thrombosis if patient's long-term bed.Therefore, there is biology
Active tantalum metal or tantalum alloy can obtain the stabilization than traditional material earlier, are conducive to patient's leaving the bed earlier and carry out function
It takes exercise, effectively prevents the appearance of such complication.
3) the bone defect repair support ontology has hollow cavity, can adjust the size of hollow cavity as needed, keep away
Exempt from the overweight situation of prosthese.
4) has well-regulated porous knot using the bone defect repair support of 3D printing technique (selective laser melting) preparation
Structure such as brilliant hole, pore size controllability is more preferable, good Integrated implant effect is help to obtain, to substantially increase bone
The efficiency of defect repair can shorten the time of bone defect healing.
5) present invention is that 3D printing technique (SLM) is utilized to prepare porous tantalum implantation material for preclinical basic research and clinic
The bone defect for treating bone tumour Postoperative Residual.3D printing technique can have been designed according to imaging datas such as the CT/MRI of patient
The tantalum metal or tantalum alloy bracket of the patient are matched entirely.
Detailed description of the invention
Fig. 1 is the hollow structure schematic diagram of bone defect repair support of the present invention.
Fig. 2 is the structural schematic diagram of bone defect repair support of the present invention.
Fig. 3 is the schematic diagram after bone defect repair support of the present invention implantation.
Fig. 4 is that porous tantalum is more advantageous to cell adherence compared with conventional medical titanium alloy.
Fig. 5 is that zoopery micro-CT achieves good Integrated implant effect as the result is shown.
Appended drawing reference:
1 bone defect repair support ontology
11 hollow cavities
2 fusion surface layers
3 fixing screw holes
Specific embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this explanation
Content disclosed by book is understood other advantages and efficacy of the present invention easily.
Fig. 1 is please referred to Fig. 5.It should be clear that this specification structure depicted in this specification institute accompanying drawings, ratio, size etc., only to
Cooperate the revealed content of specification, so that those skilled in the art understands and reads, being not intended to limit the invention can be real
The qualifications applied, therefore do not have technical essential meaning, the tune of the modification of any structure, the change of proportionate relationship or size
It is whole, in the case where not influencing the effect of present invention can be generated and the purpose that can reach, it should all still fall in disclosed skill
Art content obtains in the range of capable of covering.Meanwhile in this specification it is cited as "upper", "lower", "left", "right", " centre " and
The term of " one " etc. is merely convenient to being illustrated for narration, rather than to limit the scope of the invention, relativeness
It is altered or modified, under the content of no substantial changes in technology, when being also considered as the enforceable scope of the present invention.
A kind of bone defect repair support, as depicted in figs. 1 and 2, the bone defect repair support include bone defect healing branch
Frame ontology 1 and fusion surface layer 2, the bone defect repair support ontology 1 merge surface layer 2, institute equipped with described with the contact surface of sclerotin
Bone defect repair support ontology 1 is stated with hollow cavity 11, the fusion surface layer 2 is porous structure, the bone defect healing branch
The material of frame is tantalum metal or tantalum alloy.
The bone defect repair support ontology has hollow cavity, can adjust the size of hollow cavity as needed, avoid
The overweight situation of prosthese.
By preliminary in vitro experiments by the porous tantalum stent of SLM technology 3D printing be used for the adherency of ex vivo stem cell with
And increment is the study found that tantalum metal material has better biocompatibility compared with traditional materials in this bone defect repair support
(Fig. 4): A and C is that the SEM of medical titanium alloy bracket schemes, and the amplification factor of A and C are 150 times；B and D is that tantalum metal bone defect is repaired
The amplification factor of the SEM figure of multiple bracket, B and D are 1000 times；On this basis this tantalum metal bone defect repair support is used to move
Object experiment, discovery bracket can obtain more outstanding Integrated implant effect (Fig. 5).
In a preferred embodiment, the hollow cavity 11 and the volume ratio of the bone defect repair support are 6-8:
10-13。
In a preferred embodiment, tantalum content is 2wt%~60wt% in tantalum alloy.
In a preferred embodiment, as shown in figure 3, the shape of the bone defect repair support is patient's bone defect
Shape.The shape of bone defect repair support can be adjusted according to the shape of patient's bone defect, reached and complied fully with bone defect
The requirement of shape.Have any previous implantation material not comparable in the match party face of the bone defect of complicated tumour and wounded patient
Quasi- advantage.
In a preferred embodiment, the porous structure is the layer structure of several layers, every layer of layer structure tool
There are multiple micropores, the micropore of layer and layer is interconnected.The porous structure layer can be more for diamond porous structure layer or square
Pore structure layer.
In a preferred embodiment, the bone defect repair support is equipped with several and penetrates through the bone defect healing branch
The fixing screw hole 3 of frame.
In a preferred embodiment, the porosity for merging surface layer is 60%~80%.
In a preferred embodiment, merge surface layer with a thickness of 2mm~3.5mm.
In a preferred embodiment, the aperture for merging surface layer is 600 μm~800 μm.
In a preferred embodiment, the bone defect repair support is equipped with several and penetrates through the bone defect healing branch
The fixing screw hole of frame.
Second aspect of the present invention provides the construction method of above-mentioned bone defect repair support model, includes the following steps:
1) bone threedimensional model is constructed；
The bone threedimensional model generally includes the model of each tissue, for example, the model may include skin, bone, blood
The model of the tissues such as pipe, nerve and diseased region (for example, tumour), the model can reflect out individual (for example, patient)
Skin surface and position etc. can also reflect skeletal shape and position of individual etc., can also reflect the blood of individual
The shape of the tissues such as pipe, nerve and position etc. can also reflect the tool of the shape of tumour in individual, position and its tumour
Body parameter etc. (for example, volume etc.).The bone threedimensional model can usually be constructed according to CT data and/or MRI data, structure
The softwares such as the three-dimensional reconstructions design software such as E3D can be imported data to during building, and carry out registration fusion, thus described in building
Bone threedimensional model；
2) excision extension is determined, the bone threedimensional model after simulation is cut off on the bone threedimensional model, and with
Cut-out is as initial bone defect repair support model；
When determining excision extension, the strongest position of neoplastic lesion activity is usually selected in a model (for example, neoplastic lesion model
Enclose the most active region of intracellular metabolite), as excision target, position and size are determined in a model.Those skilled in the art are optional
Suitable size and shape is selected to be cut off；
3) it regard the excision face on initial bone defect repair support model as contact surface, simultaneously by the inward-facing stretching of the contact
Layering constructs several fusion surface units, and constructs several through-holes on each fusion surface units and obtain fusion surface layer mould
Type, using the remainder after the initial bone defect repair support model removal fusion surface layer model as initial bone defect healing
Rack body model；
4) hollow cavity is constructed in the initial bone defect repair support ontology model that step 3) obtains, obtains bone defect healing
Rack body model, to obtain the bone defect repair support model.
In a preferred embodiment, further include in following technical characteristic at least one of:
1) in step 1), the bone threedimensional model is constructed by CT data and/or MRI data；
2) in step 3), each through-hole merged on surface units is interconnected；The fusion surface layer model can be diamond
Porous structure model or square porous structure model；
3) in step 3), the porosity of fusion surface layer model is 60%~80%；
4) in step 3), fusion surface layer model with a thickness of 2mm~3.5mm；
5) in step 3), the through-hole aperture for merging surface units is 600 μm~800 μm；
6) in step 4), the volume ratio of hollow cavity and bone defect repair support model is 6-8:10-13；The bone defect
Volume of the volume of recovery support model containing hollow cavity；
7) construction method of the bone defect repair support model further include: in the bone defect repair support that step 4) obtains
The fixing screw hole of several perforation bone defect repair supports is constructed on model.
Third aspect present invention provides the preparation method of above-mentioned bone defect repair support, and the preparation method includes: basis
The construction method building of above-mentioned bone defect repair support model obtains bone defect repair support model, prepares bone defect healing branch
Frame.
According to iconography (CT data and/or MRI data) reverse modeling of patient, computer stl file is generated, then will
File is transferred in the program of 3D printer, starts to print.Print procedure: it is successively printed from bottom to top according to stl file.
Printing raw material is tantalum metal powder or tantalum alloy powder, and whole process is all to carry out in an argon atmosphere.Firstly, in the base of printing
One layer of tantalum metal powder or tantalum alloy powder are laid on plate, then the laser printing hair of printer penetrates high energy laser, by tantalum
Metal powder or tantalum alloy powder are melted according to the first layer in stl file, and then, machine can uniformly cover one layer of new powder
It covers on this layer of powder and starts to print the second layer, this process repeats to printing to terminate.
In a preferred embodiment, bone defect repair support is prepared by 3D printing, further includes following technical characteristic
At least one of in:
1) raw material of 3D printing is tantalum metal powder or tantalum alloy powder；
2) 3D printing is carried out under an inert atmosphere；
3) when 3D printing, it is successively laid with tantalum metal or tantalum alloy powder, then laser melting, realizes successively printing.
A kind of computer readable storage medium is stored thereon with computer program, real when described program is executed by processor
Now such as the step of the construction method of above-mentioned bone defect repair support model, or such as the preparation method of above-mentioned bone defect repair support
Step.
The computer readable storage medium, those of ordinary skill in the art will appreciate that: realize that above-mentioned each method is implemented
The all or part of the steps of example can be completed by the relevant hardware of computer program.Computer program above-mentioned can store
In a computer readable storage medium.When being executed, execution includes the steps that above-mentioned each method embodiment to the program；And it is aforementioned
Storage medium include: the various media that can store program code such as ROM, RAM, magnetic or disk.
A kind of equipment, comprising: processor and memory, the memory is for storing computer program, the processor
For executing the computer program of the memory storage, so that the equipment executes the model such as above-mentioned bone defect repair support
The step of construction method, or as above-mentioned bone defect repair support preparation method the step of.
Embodiment 1
A kind of bone defect repair support, including bone defect repair support ontology 1 and fusion surface layer 2, the bone defect healing
Rack body 1 merges surface layer 2 equipped with described with the contact surface of sclerotin, and the bone defect repair support ontology 1 has hollow cavity
11, the fusion surface layer 2 is porous structure, and the material of the bone defect repair support is tantalum metal.The hollow cavity 11 with
The volume ratio of the bone defect repair support is 6:10.The shape of the bone defect repair support is the shape of patient's bone defect.
The porous structure is the layer structure of several layers, and every layer of layer structure has multiple micropores, and the micropore of layer and layer mutually interconnects
It is logical.Merge surface layer with a thickness of 3.5mm, the aperture for merging surface layer is 800 μm, and the porosity for merging surface layer is 70%.The bone
Defect repair branch is provided with several fixing screw holes 3 for penetrating through the bone defect repair support.The bone defect repair support
Trapezoidal for class, upper fusion surface layer length is 50mm, and it is highly 30mm that lower fusion surface layer length, which is 28mm,.
The preparation method of above-mentioned bone defect repair support, includes the following steps:
1) bone threedimensional model is constructed；
The bone threedimensional model generally includes the model of each tissue, for example, the model may include skin, bone, blood
The model of the tissues such as pipe, nerve and diseased region (for example, tumour), the model can reflect out individual (for example, patient)
Skin surface and position etc. can also reflect skeletal shape and position of individual etc., can also reflect the blood of individual
The shape of the tissues such as pipe, nerve and position etc. can also reflect the tool of the shape of tumour in individual, position and its tumour
Body parameter etc. (for example, volume etc.).The bone threedimensional model can usually be constructed according to CT data and/or MRI data, structure
The softwares such as E3D three-dimensional reconstruction design software can be imported data to during building, and carry out registration fusion, to construct the bone
Threedimensional model；
2) excision extension is determined, the bone threedimensional model after simulation is cut off on the bone threedimensional model, and with
Cut-out is as initial bone defect repair support model；
When determining excision extension, the strongest position of neoplastic lesion activity is usually selected in a model (for example, neoplastic lesion model
Enclose the most active region of intracellular metabolite), as excision target, position and size are determined in a model.Those skilled in the art are optional
Suitable size and shape is selected to be cut off；
3) it regard the excision face on initial bone defect repair support model as contact surface, simultaneously by the inward-facing stretching of the contact
Layering constructs several fusion surface units, and constructs several through-holes on each fusion surface units and obtain fusion surface layer mould
Type, using the remainder after the initial bone defect repair support model removal fusion surface layer model as initial bone defect healing
Rack body model；
4) hollow cavity is constructed in the initial bone defect repair support ontology model that step 3) obtains, obtains bone defect healing
Rack body model, to obtain the bone defect repair support model；
The volume ratio of hollow cavity and bone defect repair support model is 6:10；
The porosity for merging surface layer model is 60%~80%；
Merge surface layer model with a thickness of 2mm~3.5mm；
The through-hole aperture for merging surface units is 600 μm~800 μm；
5) bone defect repair support is prepared；
According to iconography (CT data and/or MRI data) reverse modeling of patient, computer stl file is generated, then will
File is transferred in the program of 3D printer, starts to print.Print procedure: it is successively printed from bottom to top according to stl file.
Printing raw material is tantalum metal powder, and whole process is all to carry out in an argon atmosphere.Firstly, being laid with one layer on the substrate of printing
Tantalum metal powder or tantalum alloy powder, then the laser printing hair of printer penetrates high energy laser, by tantalum metal powder according to
First layer melting in stl file, then, machine can start one layer of new powder uniform fold to beat on this layer of powder
The second layer is printed, this process repeats to printing to terminate.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (10)
1. a kind of bone defect repair support, which is characterized in that the bone defect repair support includes bone defect repair support ontology
(1) and fusion surface layer (2), the bone defect repair support ontology (1) merge surface layer (2) equipped with described with the contact surface of sclerotin,
The bone defect repair support ontology (1) has hollow cavity (11), and the fusion surface layer (2) is porous structure, and the bone lacks
The material for damaging recovery support is tantalum metal or tantalum alloy.
2. bone defect repair support as described in claim 1, which is characterized in that further include at least one in following technical characteristic
:
1) volume ratio of the hollow cavity (11) and the bone defect repair support is 6-8:10-13；
2) tantalum content is 2wt%~60wt% in tantalum alloy；
3) shape of the bone defect repair support is the shape of patient's bone defect；
4) porous structure is the layer structure of several layers, and every layer of layer structure has multiple micropores, the micropore of layer and layer
It is interconnected；
5) bone defect repair support is equipped with several and penetrates through the fixing screw hole (3) of the bone defect repair support；
6) porosity for merging surface layer is 60%~80%.
3. bone defect repair support as described in claim 1, which is characterized in that merge surface layer with a thickness of 2mm~3.5mm.
4. bone defect repair support as described in claim 1, which is characterized in that the aperture for merging surface layer is 600 μm~800 μ
m。
5. such as the construction method of the described in any item bone defect repair support models of Claims 1-4, which is characterized in that including
Following steps:
1) bone threedimensional model is constructed；
2) excision extension is determined, the bone threedimensional model after simulation is cut off on the bone threedimensional model, and with excision
Part is used as initial bone defect repair support model；
3) it regard the excision face on initial bone defect repair support model as contact surface, by the inward-facing stretching of the contact and is layered
Several fusion surface units are constructed, and constructs several through-holes on each fusion surface units and obtains fusion surface layer model, it will
Remainder after the initial bone defect repair support model removal fusion surface layer model is as initial bone defect repair support
Ontology model；
4) hollow cavity is constructed in the initial bone defect repair support ontology model that step 3) obtains, obtains bone defect repair support
Ontology model, to obtain the bone defect repair support model.
6. the construction method of bone defect repair support model as claimed in claim 5, which is characterized in that further include following technology
At least one of in feature:
1) in step 1), the bone threedimensional model is constructed by CT data and/or MRI data；
2) in step 3), each through-hole merged on surface units is interconnected；
3) in step 3), the porosity of fusion surface layer model is 60%~80%；
4) in step 3), fusion surface layer model with a thickness of 2mm~3.5mm；
5) in step 3), the through-hole aperture for merging surface units is 600 μm~800 μm；
6) in step 4), the volume ratio of hollow cavity and bone defect repair support model is 6-8:10-13；
7) construction method of the bone defect repair support model further include: in the bone defect repair support model that step 4) obtains
The fixing screw hole of several perforation bone defect repair supports of upper building.
7. such as the preparation method of the described in any item bone defect repair supports of Claims 1-4, which is characterized in that the preparation
Method includes: that the construction method building of bone defect repair support model according to claim 5 or 6 obtains bone defect healing
Stent model prepares bone defect repair support.
8. the preparation method of bone defect repair support as claimed in claim 7, which is characterized in that prepare bone by 3D printing and lack
Damage recovery support, further includes at least one in following technical characteristic:
1) raw material of 3D printing is tantalum metal powder or tantalum alloy powder；
2) 3D printing is carried out under an inert atmosphere；
3) when 3D printing, it is successively laid with tantalum metal or tantalum alloy powder, then laser melting, realizes successively printing.
9. a kind of computer readable storage medium, is stored thereon with computer program, which is characterized in that described program is by processor
The step of construction method such as bone defect repair support model described in claim 5 or 6 is realized when execution, or such as claim
The step of preparation method of bone defect repair support described in 7 or 8.
10. a kind of equipment, comprising: processor and memory, the memory are used for storing computer program, the processor
In the computer program for executing the memory storage, so that the equipment is executed as bone defect described in claim 5 or 6 is repaired
The step of construction method of multiple stent model, or the step of the preparation method of bone defect repair support as claimed in claim 7 or 8
Suddenly.
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