CN110403661B

CN110403661B - Bionical driven alimentary canal magnetism anastomosis device of wheat mango

Info

Publication number: CN110403661B
Application number: CN201810389425.4A
Authority: CN
Inventors: 吕毅; 单丽宇; 杜妍莹; 马锋; 严小鹏; 吴荣谦
Original assignee: First Affiliated Hospital of Medical College of Xian Jiaotong University
Current assignee: Chonghao Technology Co.,Ltd.
Priority date: 2018-04-27
Filing date: 2018-04-27
Publication date: 2021-06-08
Anticipated expiration: 2038-04-27
Also published as: CN110403661A

Abstract

A kind of awn bionically driven alimentary canal magnetic anastomosis device, including: the tail whisker simulating the physical structure of the awn, a central column connected with the tail whisker, a pull wire made of biodegradable materials such as polylactic acid compounds, polyglycolide and the like, a nested capsule which can be decomposed in gastric juice, and two neodymium iron boron magnets. Can be used for treating obesity and controlling diabetes, hypertension, and hyperlipidemia related to obesity.

Description

Bionical driven alimentary canal magnetism anastomosis device of wheat mango

Technical Field

The invention belongs to the technical field of medical instruments, and particularly relates to a wheat-mango bionic driving digestive tract magnetic anastomosis device.

Background

With the changing development of human life style and society, obesity has become more common worldwide, and diseases related to obesity, such as diabetes, hyperlipidemia, hypertension and coronary heart disease, are more common. The currently common weight-losing operations are divided into three categories. The first, restrictive, such as adjustable gastric banding (LAGB); the second, malabsorptive types, such as biliopancreatic shunts (BDP); the third category, combined, is gastric bypass surgery (GBP).

The three types of operations can help reduce the absorption of chyme by duodenum and jejunum, achieve weight loss and control obesity-related diseases such as diabetes and the like, but can not solve the fundamental problems of large body damage, serious rejection reaction of human bodies and more postoperative complications.

Also, in either way, there are some problems and risks to varying degrees.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention aims to provide a wheat-mango bionic-driven digestive tract magnetic anastomosis device, which pulls a magnet to perform intestinal anastomosis on a duodenum (according to the pylorus of 5cm-15cm) and an upper segment of a jejunum (30 cm-50cm away from a ligament of dorsifleya) so as to form an intestinal bypass. Food does not pass through the duodenum and upper jejunum, and chyme that is not fully digested reaches the terminal ileum prematurely, which can reduce weight and control diabetes and other diseases associated with obesity. Pories et al speculate that type 2 diabetes is due to excessive production of a hormone in the proximal small intestine, antagonizing insulin activity, and the intestinal anastomosis performed in the present invention avoids food irritation at the site of hormone secretion that may cause diabetes. Simultaneously, the effective absorption area of the small intestine to food is reduced, and the food can be used for losing weight of obese patients and controlling various metabolic diseases including diabetes.

In order to achieve the purpose, the invention adopts the technical scheme that:

the utility model provides a bionical driven alimentary canal magnetism anastomosis device of wheat awn, its characterized in that, including being easily by nested capsule 1 that gastric juice dissolves, has center post 3 in nested capsule 1, the side of center post 3 is provided with a plurality of tail silks 2, tail silks 2 use the length direction of center post 3 to form as the axle and gather together the effect, gather together the head end towards the front end of center post 3, diverge the tail end towards the tail end of center post 3 to form the resistance on drawing the opposite direction, the end-to-end connection resolvable haulage line 4 of center post 3, nested capsule 1 is worn out to the tail end of haulage line 4, and haulage line 4 is connected with two magnets 5 that are used for the magnetic anchoring on the part outside nested capsule 1.

The tail whiskers 2 simulate the physical structure of the ear of wheat on the central column 3.

The tail whiskers 2 are made of materials with certain flexibility, acid and alkali corrosion resistance, such as natural wheat and mango, bristles and horsehair, and are 5-7mm long; the central column 3 is made of acid-resistant, alkali-resistant and non-magnetic materials such as rubber and the like, and has the length of 15-25mm and the diameter of 8-35 mm.

The nested capsule 1 is made of materials which are good in biocompatibility and free of cytotoxicity, can be quickly dissolved by gastric juice, such as sugar coating, ice film and the like, and is 17-27mm in length and 10-37mm in diameter.

The distance between the two magnets 5 is 50cm-70cm, and the two magnets are fixed on the traction wire 4.

Compared with the prior art, the invention has the beneficial effects that:

1. the traction efficiency of the magnet is improved, and compared with the prior art that most magnets are conveyed by means of a laparoscope, the traction device reduces the damage to the body.

2. The decomposable traction wire can control the decomposition time by controlling the cross-sectional area of the decomposable traction wire.

3. The two magnets enter the intestinal tract through oral administration, compared with the existing weight-losing operation, the oral-administration type weight-losing device has no wound, is short in recovery time, and reduces the risks of rejection, infection and the like of a patient caused by external implants.

4. The operation materials involved in the intestinal anastomosis can be discharged out of the body or decomposed and absorbed by the human body, and do not need to be taken out through the operation.

Drawings

FIG. 1 is a complete schematic view of the present invention.

Figure 2 is a schematic view of a nested capsule removed.

Figure 3 is a rear view of the nested capsule removed.

Figure 4 is a front view of the nested capsule removed.

FIG. 5 is a schematic view showing the magnet being delivered into the body.

Fig. 6 is a schematic view of the anchoring of a magnet in vivo.

Fig. 7 is a schematic diagram of the squeezing of the magnets in vivo to form a stoma.

Detailed Description

For the purpose of facilitating an understanding of the objects, technical solutions and effects of the present invention, the present invention will now be described in further detail with reference to examples.

As shown in figure 1, the unmanaged bionic driven digestive tract magnetic anastomosis device comprises a nested capsule 1 which is easy to dissolve by gastric juice, wherein the nested capsule 1 is made of materials with good biocompatibility and no cytotoxicity, such as sugar coating, ice film and the like, which can be quickly dissolved by the gastric juice, and the length of the nested capsule 1 is 10mm-37mm (diameter) multiplied by 17mm-27mm (length). A central column 3 is arranged in the nested capsule 1, the central column 3 is made of acid-resistant, alkali-resistant and non-magnetic materials such as rubber, and the length of the central column 3 is 8mm-35mm (diameter) multiplied by 15mm-25mm (length).

The side of the central column 3 is provided with a plurality of tail whiskers 2, the tail whiskers 2 are made of materials with certain toughness and acid and alkali corrosion resistance, such as natural wheat awn, pig bristle, horse bristle and the like, the head is blunt and round, and the length is 5-7 mm. The tail hair 2 is on center post 3, and the physical structure of simulation ear of wheat to the length direction of center post 3 forms the effect of gathering together as the axle, gathers together the head end and towards the front end of center post 3, diverges the tail end and towards the tail end of center post 3, thereby forms the resistance in pulling the opposite direction. The nested capsule 1, the central column 3 and the tail whisker 2 form a tractor, and the nested capsule 1 is triggered to be dissolved by gastric juice before the tractor passes through the pylorus to the duodenum, so that the tail whisker 2 is exposed in the intestinal cavity.

The tail end of the central column 3 is connected with a decomposable pull wire 4, the tail end of the pull wire 4 penetrates out of the nested capsule 1, two magnets 5 for magnetic anchoring are fixed on the part of the pull wire 4 outside the nested capsule 1, the distance between the two magnets 5 is 50cm-70cm, the pull wire 4 is made of biodegradable materials such as polylactic acid compounds and polyglycolide, the decomposition time of the pull wire 4 is predicted by controlling the cross sectional area of the pull wire 4, and the falling point of the two magnets 5 swallowed successively in the small intestine is controlled.

The device can be used for intestinal anastomosis, and further, the duodenum-jejunum anastomosis performed through magnetic anchoring can be used for treating obesity and controlling diseases such as diabetes, hyperlipidemia, hypertension and the like related to obesity.

Referring to fig. 5, 6 and 7, a specific method of use of the present device is as follows:

before operation, according to the specific anastomotic site of the intestinal tract of a patient, the two magnets 5 are fixed at the corresponding positions of the pull wire 4, and the corresponding truncated cross-sectional areas of the pull wire 4 are determined according to the dissolution time of the pull wire 4.

To avoid attraction of the two magnets 5 in the stomach, the patient first swallows the retractor and the first magnet, and then swallows the second magnet after confirming that the first magnet has entered the duodenum by B-mode ultrasound or other observation means.

The tail whisker 2 simulating the physical structure of the Miscanthus sinensis is used, and before the tractor enters duodenum from the pylorus, the nested capsule 1 is dissolved by gastric acid to trigger the tail whisker 2, so that the retraction of peristaltic waves to the tractor is inhibited, the advancing efficiency of the tractor in the small intestine is improved, and the moving speed of the magnet 5 is accelerated.

The two magnets 5 move under the action of the tractor, when the traction wire 4 reaches the designated position, the traction wire is dissolved and broken, and the two magnets 5 stop moving.

The two magnets 5 in the small intestine are connected and anchored through the extraabdominal magnet, an anastomotic stoma is formed by squeezing, the magnet falls off after 10 days as a bypass, the magnet is discharged out of the body after 12 days, and the rest part of the tractor is discharged out of the body within 72 hours after swallowing.

Claims

1. The utility model provides a bionical driven alimentary canal magnetism anastomosis device of awn, its characterized in that includes nested capsule (1) that is easy to be dissolved by gastric juice, has center post (3) in nested capsule (1), and the side of center post (3) is provided with a plurality of tails (2), tail whisker (2) use the length direction of center post (3) as the axle and form and gather together the effect, gather together the head end and face the front end of center post (3), diverge the tail end and face the tail end of center post (3), thereby form the resistance in drawing the opposite direction, the tail end of center post (3) is connected with decomposable line (4), the tail end of pull wire (4) is worn out nested capsule (1), pull wire (4) are fixed with two magnets (5) that are used for the magnetic anchoring on the part outside nested capsule (1), the interval of two magnets (5) is 50cm-70cm, predict its decomposition time through the cross-sectional area of control pull wire (4), controlling the landing of two magnets (5) swallowed sequentially in the small intestine.

2. The awn biomimetic driven alimentary magnetic anastomosis device according to claim 1, characterized in that the tail whiskers (2) mimic the physical structure of an ear of wheat on the central post (3).

3. The awn biomimetic driven digestive tract magnetic anastomosis device according to claim 1, wherein the tail whiskers (2) are made of a material with flexibility, acid and alkali corrosion resistance and are 5-7mm long; the central column (3) is made of acid-resistant, alkali-resistant and non-magnetic materials, and is 15-25mm long and 8-35mm in diameter.

4. The biomimetic wheat-mango-driven digestive tract magnetic anastomosis device according to claim 3, wherein the material with flexibility, acid-base corrosion resistance and acid-base corrosion resistance is natural wheat-mango, pig bristle or horse bristle, and the acid-base corrosion resistance and non-magnetic material is rubber.

5. The awn biomimetic driven digestive tract magnetic anastomosis device according to claim 1, characterized in that the nested capsule (1) is made of biocompatible and non-cytotoxic material which can be rapidly dissolved by gastric juice, and has a length of 17-27mm and a diameter of 10-37 mm.

6. The awn biomimetic driven digestive tract magnetic anastomosis device according to claim 5, wherein the biocompatible and non-cytotoxic material which can be rapidly dissolved by gastric juice is sugar-coated or ice-coated.