CN207886462U - Alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy - Google Patents
Alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy Download PDFInfo
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- CN207886462U CN207886462U CN201720447025.5U CN201720447025U CN207886462U CN 207886462 U CN207886462 U CN 207886462U CN 201720447025 U CN201720447025 U CN 201720447025U CN 207886462 U CN207886462 U CN 207886462U
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Abstract
The utility model discloses a kind of biodegradable no-station pole canopies, and alimentary canal capsule-type stapler is isolated, the stapler includes main body tube 1, main body tube is made of mesh skeleton structure sheaf 2 with the hydrophobic nano fiber film layer 3 for being coated on 2 outer surface of mesh skeleton structure sheaf, it is connected separately with hemispherical or half capsule shape Hydrophilic Nanofibrous film sealing end 4 at the both ends of main body tube, alimentary canal capsule-type stapler is isolated in the biodegradable no-station pole canopy of the utility model, gastrointestinal contents and tissue at gastrointestinal anastomosis are kept apart, not only facilitate the growth healing accelerated outside gastrointestinal anastomosis, improve the chance of success of gastrointestinal anastomosis, the generation of anastomotic leakage is reduced to the greatest extent；It is prepared, can be degradable after anastomotic healing and be excreted using biodegradability medical macromolecular materials, had no toxic side effect；Making step is simple, low manufacture cost, can reduce the medical expense of patient；It effectively shortens wholistic therapy period of patient, avoids the secondary pain brought to patient.
Description
Technical field
The utility model belongs to surgical medical equipment technical field, is related to a kind of isolation of biodegradable no-station pole canopy and disappears
Change road capsule-type stapler.
Background technology
Gastrointestinal anastomosis operation is that abdominal surgery is most basic, most common operating technology, while being also postoperative to be easier to occur simultaneously
Send out the operation of disease.Stomach and intestine mouth fistula is the postoperative relatively common lethal complication of gastrointestinal anastomosis, and gastrointestinal anastomosis fistula refers to stomach and intestine
Defect at previous anastomotic causes the content in enteron aisle to be flowed out from the defect, to induce infection, organ dysfunction, battalion
A series of lesions such as bad and body fluid loss are supported, after patient carries out gastrointestinal procedures, the probability of concurrent stomach and intestine mouth fistula is about 2%-
50.4%.Clinical research shows that serious stomach and intestine mouth fistula does not only result in the generation of other complication, or even dead, and extension is hospitalized
Time, and patient's economy, the burden of spirit are increased, greatly reduce the therapeutic effect of operation and the pre- aftereffect of operation
Fruit.Therefore, gastrointestinal anastomosis is postoperative, and how to promote previous anastomotic quickly to heal is effective important way for reducing and postoperative complications occur
Diameter.
Gastrointestinal anastomosis method includes mainly two methods of manual, Mechanical Suture, and manual method is time-honored identical method,
Completed using silk thread or absorbable thread manual suture, but the operation of this method is cumbersome, process takes, different operation doctor it
Between tact skill differ greatly.Currently, Mechanical Suture is also a kind of postoperative identical important means of promotion alimentary canal, in manual kiss
Specific position of valid operation difficulty, such as esophagus lower end, basin intralumenal anastomosis etc. have apparent advantage easy to operate.But
It is that it is different to remain anastomosis staple etc. throughout one's life due to the stapler non-degradable designed on current medical market, in anastomosis operation pneumoretroperitoneum
Object, this causes many pains to patient, sometimes even entail dangers to patient vitals.
Utility model content
The purpose of the utility model is to overcome the deficiencies in the prior art, provide one kind can improve gastrointestinal anastomosis success rate,
Avoid the occurrence of gastrointestinal fistula danger, the biodegradable no-station pole canopy isolation alimentary canal glue that internal foreign remains and medical treatment cost is low
Bladder type stapler.
The technical solution of the utility model is summarized as follows：
Alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, including main body tube 1, the main body tube are by netted
Skeleton structure layer 2 and the hydrophobic nano fiber film layer 3 for being coated on 2 outer surface of mesh skeleton structure sheaf form, in main body tube
Both ends are connected separately with hemispherical or half capsule shape Hydrophilic Nanofibrous film sealing end 4.
The material of mesh skeleton structure is that weight average molecular weight is the poly-L-lactide of 20-100 ten thousand, weight average molecular weight 20-
1000000 poly- D- lactides, the poly- D that weight average molecular weight is 20-100 ten thousand, L- lactides, weight average molecular weight are 20-100's ten thousand
Poly- (L- lactide-co-glycolides) that polyglycolide, weight average molecular weight are 20-100 ten thousand, weight average molecular weight are 20-100 ten thousand
Poly- 6-caprolactone, the polydioxanone that weight average molecular weight is 20-100 ten thousand and weight average molecular weight be the poly- of 20-100 ten thousand
At least one of Trimethylene Carbonate.
The material of hydrophobic nano tunica fibrosa be weight average molecular weight be 5-20 ten thousand poly- (L- lactide-co-glycolides),
At least one in the poly- 6-caprolactone that weight average molecular weight is 5-20 ten thousand and the polydioxanone that weight average molecular weight is 5-20 ten thousand
Kind.
Hydrophilic Nanofibrous membrane material be weight average molecular weight be 0.5-14 ten thousand, the polyvinyl alcohol of alcoholysis degree 88-98%, again
Average molecular weight is the polyvinylpyrrolidone of 0.5-20 ten thousand, glue intensity is the gelatin of 100~200g Bloom, weight average molecular weight is
The polyacrylic acid of 0.2-20 ten thousand, carboxymethyl cellulose, potato starch, cornstarch and the wood that viscosity is 300-4500mPa.s
At least one of sweet potato starch.
The advantages of the utility model：
1. alimentary canal capsule-type stapler is isolated in the biodegradable no-station pole canopy of the utility model, by gastrointestinal contents and stomach
Tissue is kept apart at Surgical healing, is not only facilitated the growth healing accelerated outside gastrointestinal anastomosis, is improved the chance of success of gastrointestinal anastomosis,
The generation of anastomotic leakage is reduced to the greatest extent；
2. prepared using biodegradability medical macromolecular materials, can be degradable after anastomotic healing and body be discharged
Outside, it has no toxic side effect；
3. it is at low cost, the medical expense of patient can be reduced；
4. effectively shortening wholistic therapy period of patient, the secondary pain brought to patient is avoided.
Description of the drawings
Fig. 1 is the article body for the biodegradable no-station pole canopy isolation alimentary canal capsule-type stapler for forming the utility model
Pipe structural schematic diagram.
Fig. 2 is that the structural schematic diagram of alimentary canal capsule-type stapler is isolated in the biodegradable no-station pole canopy of the utility model.
Fig. 3 is that alimentary canal capsule-type stapler hydrophobic nano fiber is isolated in the biodegradable no-station pole canopy of the utility model
Film electron scanning micrograph.
Specific implementation mode
The utility model is further described in the following with reference to the drawings and specific embodiments.
Embodiment 1
Alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, sees Fig. 2, including main body tube 1, sees Fig. 1, main body tube
It is made of mesh skeleton structure sheaf 2 and the hydrophobic nano fiber film layer 3 for being coated on 2 outer surface of mesh skeleton structure sheaf,
The both ends of main body tube are connected separately with hemispherical Hydrophilic Nanofibrous film sealing end 4.
The material of mesh skeleton structure is the poly-L-lactide that weight average molecular weight is 1,000,000.
The material of hydrophobic nano tunica fibrosa is poly- (the L- lactide-co-glycolide) that weight average molecular weight is 200,000；
Hydrophilic Nanofibrous membrane material be weight average molecular weight be 0.5 ten thousand, the polyvinyl alcohol of alcoholysis degree 88% and glue intensity
Gelatin for 100g Bloom is 1 in mass ratio：1 mixture；
The preparation method of alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, includes the following steps：
(1) mesh skeleton structural material is made into a diameter of 4cm, length 10cm by melting extrusion method, wall thickness is
The tubular mesh skeleton structure layer of 0.1cm；
(2) it is 1 hydrophobic nano fiber film material to be dissolved in volume ratio:3 N,N-dimethylformamide and tetrahydrofuran
In the mixed solvent, it is that 10% the first spinning solution is being set using TL-Pro-BM type electrospinning devices that mass concentration, which is made,
It is humidity 40% to determine air, and voltage is+12kV, and -0.2kV, receiver tubulose mesh skeleton structure sheaf distance is 10cm, by 2mL
The first spinning solution sucks in 10mL syringes, is 2mL/h in spinning rate, spinning is carried out to tubular mesh skeleton structure layer
1h is obtained by mesh skeleton structure sheaf 2 and 3 groups of hydrophobic nano fiber film layer for being coated on 2 outer surface of mesh skeleton structure sheaf
At main body tube；
(3) material of Hydrophilic Nanofibrous film is dissolved in ultra-pure water, second of spinning that mass concentration is 33% is made
Silk solution is humidity 30% in setting air, voltage is+12kV, -0.5kV, is connect using TL-Pro-BM type electrospinning devices
It is 20cm to receive device distance, by second of spinning solution sucking 10mL syringe of 2mL, is 2mL/h in spinning rate, carries out spinning
1h；Hemispherical Hydrophilic Nanofibrous film sealing end is prepared, the receiver is hemisphere；
(4) main body tube and two hemispherical Hydrophilic Nanofibrous films are blocked, is bonded using Mecrilate
Agent links together.
Embodiment 2
Alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, including main body tube 1, main body tube are by mesh skeleton
Structure sheaf 2 and the hydrophobic nano fiber film layer 3 for being coated on 2 outer surface of mesh skeleton structure sheaf form, at the both ends of main body tube
It is connected separately with half capsule shape Hydrophilic Nanofibrous film sealing end 4.
The material of mesh skeleton structure is the poly-L-lactide that weight average molecular weight is 200,000 and weight average molecular weight is 200,000
Poly- D- lactides are 1 in mass ratio:1 mixing.
The material of hydrophobic nano tunica fibrosa is：The poly- 6-caprolactone and weight average molecular weight that weight average molecular weight is 200,000 be
200000 polydioxanone is 1 in mass ratio:1 mixing.
Hydrophilic Nanofibrous membrane material is preferred：The polyvinylpyrrolidone and glue intensity that weight average molecular weight is 200,000 be
The gelatin of 100g Bloom is 1 in mass ratio:1 mixing.
The preparation method of alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, includes the following steps：
(1) mesh skeleton structural material is made into a diameter of 10cm, length 1cm by melting extrusion method, wall thickness is
The tubular mesh skeleton structure layer of 0.5cm；
(2) it is 1 hydrophobic nano fiber film material to be dissolved in volume ratio:1 N,N-dimethylformamide and tetrahydrofuran
The first spinning solution that mass concentration is 33% is made in the mixed solvent, is wet in setting air using electrospinning device
Degree 60%, voltage are+15kV, and -1.2kV, receiver tubulose mesh skeleton structure sheaf distance is 20cm, by the first spinning of 10mL
Solution suck 10mL syringes in, spinning rate be 5mL/h, to tubular mesh skeleton structure layer carry out spinning 2h, obtain by
The main body that mesh skeleton structure sheaf 2 and the hydrophobic nano fiber film layer 3 for being coated on 2 outer surface of mesh skeleton structure sheaf form
Pipe；
(3) material of Hydrophilic Nanofibrous film is dissolved in ultra-pure water, second of spinning that mass concentration is 5% is made
Solution is humidity 30% in setting air using electrospinning device, and voltage is+12kV, -1.5kV, and receiver distance is
10cm is 2mL/h in spinning rate, carries out spinning 1h by second of spinning solution sucking 10mL syringe of 2mL；Prepare half
Capsule shape Hydrophilic Nanofibrous film blocks, and the receiver is that hemisphere and cylinder are integral；
(4) main body tube and two and half capsule shape Hydrophilic Nanofibrous films are blocked, it is viscous using Mecrilate
Knot agent links together.
Embodiment 3
Alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, including main body tube 1, main body tube are by mesh skeleton
Structure sheaf 2 and the hydrophobic nano fiber film layer 3 for being coated on 2 outer surface of mesh skeleton structure sheaf form, at the both ends of main body tube
It is connected separately with hemispherical Hydrophilic Nanofibrous film sealing end 4.
The material of mesh skeleton structure：The polyglycolide and weight average molecular weight that weight average molecular weight is 400,000 are 400,000 poly- (L-
Lactide-co-glycolide) it is 1 in mass ratio:The mixing of 1 ratio.
The material of hydrophobic nano tunica fibrosa：Poly- (the L- lactide-co-glycolides) and again that weight average molecular weight is 100,000
The polydioxanone that average molecular weight is 100,000 is 1 in mass ratio:The mixing of 1 ratio.
Hydrophilic Nanofibrous membrane material：The carboxylic first that the polyacrylic acid and viscosity that weight average molecular weight is 20,000 are 1000mPa.s
Base cellulose is 1 in mass ratio:The mixing of 1 ratio.
The preparation method of alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, includes the following steps：
(1) mesh skeleton structural material is made into a diameter of 4cm, length 10cm by melting extrusion method, wall thickness is
The tubular mesh skeleton structure layer of 0.3cm；
(2) it is 1 hydrophobic nano fiber film material to be dissolved in volume ratio：1 N,N-dimethylformamide and tetrahydrofuran
In the mixed solvent, be made mass concentration be 18% the first spinning solution be in setting air using electrospinning device
Humidity 50%, voltage are+13kV, and -1.0kV, receiver tubulose mesh skeleton structure sheaf distance is 15cm, by the first spinning of 8mL
In silk solution sucking 10mL syringes, it is 4mL/h in spinning rate, spinning 2h is carried out to tubular mesh skeleton structure layer, is obtained
By mesh skeleton structure sheaf 2 and it is coated on the main body that the hydrophobic nano fiber film layer 3 of 2 outer surface of mesh skeleton structure sheaf forms
Pipe；
(3) material of Hydrophilic Nanofibrous film is dissolved in ultra-pure water, second of spinning that mass concentration is 25% is made
Silk solution is humidity 40% in setting air using electrospinning device, and voltage is+15kV, -0.7kV, and receiver distance is
12cm is 2mL/h in spinning rate, carries out spinning 3h by second of spinning solution sucking 10mL syringe of 6mL；Prepare half
Spherical Hydrophilic Nanofibrous film sealing end, the receiver are hemisphere；
(4) main body tube and two hemispherical Hydrophilic Nanofibrous films are blocked, is bonded using Mecrilate
Agent links together.
Embodiment 4
Alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, including main body tube 1, main body tube are by mesh skeleton
Structure sheaf 2 and the hydrophobic nano fiber film layer 3 for being coated on 2 outer surface of mesh skeleton structure sheaf form, at the both ends of main body tube
It is connected separately with hemispherical Hydrophilic Nanofibrous film sealing end 4.
The material of mesh skeleton structure：The poly- D that weight average molecular weight is 500,000, L- lactides and weight average molecular weight are 500,000
Poly- 6-caprolactone is 2 in mass ratio:The mixing of 1 ratio.
The material of hydrophobic nano tunica fibrosa：Poly- (the L- lactide-co-glycolides) and again that weight average molecular weight is 80,000
The poly- 6-caprolactone that average molecular weight is 80,000 is 1 in mass ratio:The mixing of 1 ratio.
Hydrophilic Nanofibrous membrane material：Weight average molecular weight is the polyvinyl alcohol and Weight-average molecular of 140,000, alcoholysis degree 98%
Amount is 0.5 ten thousand polyvinylpyrrolidone, is in mass ratio 1:The mixing of 1 ratio.
The preparation method of alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, includes the following steps：
(1) mesh skeleton structural material is made into a diameter of 1cm, length 20cm by melting extrusion method, wall thickness is
The tubular mesh skeleton structure layer of 0.1cm；
(2) it is 1 hydrophobic nano fiber film material to be dissolved in volume ratio：1 N,N-dimethylformamide and tetrahydrofuran
In the mixed solvent, be made mass concentration be 18% the first spinning solution be in setting air using electrospinning device
Humidity 50%, voltage are+13kV, and -1.0kV, receiver tubulose mesh skeleton structure sheaf distance is 15cm, by the first spinning of 10mL
In silk solution sucking 10mL syringes, it is 2mL/h in spinning rate, spinning 5h is carried out to tubular mesh skeleton structure layer, is obtained
By mesh skeleton structure sheaf 2 and it is coated on the main body that the hydrophobic nano fiber film layer 3 of 2 outer surface of mesh skeleton structure sheaf forms
Pipe；
(3) material of Hydrophilic Nanofibrous film is dissolved in ultra-pure water, second of spinning that mass concentration is 25% is made
Silk solution is humidity 50% in setting air using electrospinning device, and voltage is+15kV, -0.7kV, and receiver distance is
12cm is 2mL/h in spinning rate, carries out spinning 3h by second of spinning solution sucking 10mL syringe of 6mL；Prepare half
Spherical Hydrophilic Nanofibrous film sealing end, the receiver are hemisphere；
(4) main body tube and two hemispherical Hydrophilic Nanofibrous films are blocked, is bonded using Mecrilate
Agent links together.
Embodiment 5
Alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, including main body tube 1, main body tube are by mesh skeleton
Structure sheaf 2 and the hydrophobic nano fiber film layer 3 for being coated on 2 outer surface of mesh skeleton structure sheaf form, at the both ends of main body tube
It is connected separately with hemispherical Hydrophilic Nanofibrous film sealing end 4.
The material of mesh skeleton structure：The poly-L-lactide and weight average molecular weight that weight average molecular weight is 300,000 are 300,000 poly-
D- lactides are 3 in mass ratio:The mixing of 1 ratio.
The material of hydrophobic nano tunica fibrosa：Poly- (the L- lactide-co-glycolides) and again that weight average molecular weight is 60,000
The polydioxanone that average molecular weight is 60,000 is 1 in mass ratio:The mixing of 1 ratio.
Hydrophilic Nanofibrous membrane material：Glue intensity is the gelatin of 200g Bloom, weight average molecular weight is 0.2 ten thousand poly- third
Olefin(e) acid is in mass ratio 1:The mixing of 1 ratio.
The preparation method of alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, includes the following steps：
(1) mesh skeleton structural material is made into a diameter of 4cm, length 20cm by melting extrusion method, wall thickness is
The tubular mesh skeleton structure layer of 0.5cm；
(2) it is 1 hydrophobic nano fiber film material to be dissolved in volume ratio：1 N,N-dimethylformamide and tetrahydrofuran
In the mixed solvent, be made mass concentration be 20% the first spinning solution be in setting air using electrospinning device
Humidity 50%, voltage are+13kV, and -1.0kV, receiver tubulose mesh skeleton structure sheaf distance is 15cm, by the first spinning of 10mL
In silk solution sucking 10mL syringes, it is 2mL/h in spinning rate, spinning 5h is carried out to tubular mesh skeleton structure layer, is obtained
By mesh skeleton structure sheaf 2 and it is coated on the main body that the hydrophobic nano fiber film layer 3 of 2 outer surface of mesh skeleton structure sheaf forms
Pipe；
(3) material of Hydrophilic Nanofibrous film is dissolved in ultra-pure water, second of spinning that mass concentration is 30% is made
Silk solution is humidity 50% in setting air using electrospinning device, and voltage is+16kV, -0.5kV, and receiver distance is
12cm is 2mL/h in spinning rate, carries out spinning 5h by second of spinning solution sucking 10mL syringe of 10mL；Prepare half
Spherical Hydrophilic Nanofibrous film sealing end, the receiver are hemisphere；
(4) main body tube and two hemispherical Hydrophilic Nanofibrous films are blocked, is bonded using Mecrilate
Agent links together.
Embodiment 6
Alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, including main body tube 1, main body tube are by mesh skeleton
Structure sheaf 2 and the hydrophobic nano fiber film layer 3 for being coated on 2 outer surface of mesh skeleton structure sheaf form, at the both ends of main body tube
It is connected separately with hemispherical Hydrophilic Nanofibrous film sealing end 4.
The material of mesh skeleton structure：Poly- (the L- lactide-co-glycolides) and divide equally again that weight average molecular weight is 200,000
Son amount is 200,000 poly- 6-caprolactone, is in mass ratio 2:The mixing of 1 ratio.
The material of hydrophobic nano tunica fibrosa：Poly- (the L- lactide-co-glycolides) and again that weight average molecular weight is 110,000
The polydioxanone that average molecular weight is 110,000 is 2 in mass ratio:The mixing of 1 ratio.
Hydrophilic Nanofibrous membrane material：Viscosity is carboxymethyl cellulose, cornstarch and the para arrowroot of 4500mPa.s
Powder is in mass ratio 1:1:The mixing of 1 ratio.
The preparation method of alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, includes the following steps：
(1) mesh skeleton structural material is made into a diameter of 3cm, length 15cm by melting extrusion method, wall thickness is
The tubular mesh skeleton structure layer of 0.3cm；
(2) it is 1 hydrophobic nano fiber film material to be dissolved in volume ratio：1 N,N-dimethylformamide and tetrahydrofuran
In the mixed solvent, be made mass concentration be 22% the first spinning solution be in setting air using electrospinning device
Humidity 40%, voltage are+12kV, and -1.0kV, receiver tubulose mesh skeleton structure sheaf distance is 15cm, by the first spinning of 10mL
In silk solution sucking 10mL syringes, it is 2mL/h in spinning rate, spinning 5h is carried out to tubular mesh skeleton structure layer, is obtained
By mesh skeleton structure sheaf 2 and it is coated on the main body that the hydrophobic nano fiber film layer 3 of 2 outer surface of mesh skeleton structure sheaf forms
Pipe；
(3) material of Hydrophilic Nanofibrous film is dissolved in ultra-pure water, second of spinning that mass concentration is 30% is made
Silk solution is humidity 40% in setting air using electrospinning device, and voltage is+15kV, -0.5kV, and receiver distance is
12cm is 2mL/h in spinning rate, carries out spinning 5h by second of spinning solution sucking 10mL syringe of 10mL；Prepare half
Spherical Hydrophilic Nanofibrous film sealing end, the receiver are hemisphere；
(4) main body tube and two hemispherical Hydrophilic Nanofibrous films are blocked, is bonded using Mecrilate
Agent links together.
The poly- D that the poly- D- lactides for being 1,000,000 with weight average molecular weight, weight average molecular weight are 200,000, L- lactides, weight are equal
The poly- D that molecular weight is 1,000,000, polyglycolide that L- lactides, weight average molecular weight are 200,000, weight average molecular weight be 1,000,000 it is poly-
Poly- (L- lactide-co-glycolides) that glycolide, weight average molecular weight are 1,000,000, weight average molecular weight be 200,000 it is poly- to dioxy
The polytrimethylene ring carbon acid that polydioxanone that cyclohexanone, weight average molecular weight are 1,000,000, weight average molecular weight are 200,000
Ester, the polytrimethylene cyclic carbonate ester that weight average molecular weight is 1,000,000, it is 200,000 to substitute the weight average molecular weight in the present embodiment respectively
Poly- (L- lactide-co-glycolides)；The poly- 6-caprolactone for being 1,000,000 with weight average molecular weight substitutes in the present embodiment respectively
Weight average molecular weight be 200,000 poly- 6-caprolactone, other same the present embodiment, prepare corresponding biodegradable no-station pole canopy every
From alimentary canal capsule-type stapler.
With weight average molecular weight be 50,000 poly- (L- lactide-co-glycolides), poly- ε-that weight average molecular weight is 50,000 oneself
Poly- (the L- that the weight average molecular weight that the polydioxanone that lactone and weight average molecular weight are 5 substitutes the present embodiment respectively is 110,000
Lactide-co-glycolide), other same the present embodiment prepare corresponding biodegradable no-station pole canopy isolation alimentary canal capsule
Type stapler.
The carboxymethyl cellulose that the polyacrylic acid for being 200,000 with weight average molecular weight, viscosity are 300mPa.s substitutes this reality respectively
The viscosity for applying example is the carboxymethyl cellulose of 4500mPa.s, and the cornstarch of the present embodiment, Qi Tatong are substituted with potato starch
The present embodiment prepares corresponding biodegradable no-station pole canopy isolation alimentary canal capsule-type stapler.
The use of alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy：
The utility model biodegradable no-station pole canopy is isolated to the both ends point of alimentary canal capsule-type stapler before gastrointestinal anastomosis
It is not inserted into the broken ends of fractured bone of two gastric tubes to be anastomosed, is continuously sutured one broken ends of fractured bone of gastric tube with stapler with absorbable suture
One week, then stapler and another broken ends of fractured bone are sutured, and two broken ends of fractured bone gastric tubes are sutured.Since gastric tube anastomosis is new by this practicality
Type is completely separated, avoids contact of the wound with intestinal contents, and intestinal contents will not pollute previous anastomotic, to effectively protect
Previous anastomotic is protected.
Alimentary canal capsule is isolated according to the biodegradable no-station pole canopy that the preferred dimensions such as the age of patient, intestines position match
Type stapler.
After carrying out anastomosis operation using the stapler of the utility model, extracorporeal simulating experiment proves can be complete in 30-300 days
Degradation, internal noresidue.
The stapler of the utility model uses polyethylene glycol (molecular weight 500-5000) to be smeared before implanting
Processing, can be completely dissolved after implanting in 3-6 hours, polyethylene glycol plays the role of water suction and lubrication.
The utility model not only helps in operation and makes a concentrated effort to finish reconstruction of digestive tract anastomosis operation step, and can also assist
Alimentary canal completes one-stage anastomosis, avoids digesting to the maximum extent under physiology, the even extreme pathologic condition such as inflammation oedema expansion
Road is temporary and permanent stoma.The postoperative generation for preventing anastomotic leakage, to avoid the correlation of postoperative lethal concurrent
Disease；The postoperative stapler can be degradable and excludes external, foreign residual.Traditional alimentary tract anastomosis product can effectively be made up
Permanent foreign matter remains, can not utmostly avoid the shortcomings that generation of anastomotic leakage in vivo.The utility model stapler, can not only
Enough safeties for increasing operation reduce operation lethal complication, avoid postoperative doctor-patient dispute and contradiction, improve doctor-patient relationship.
Moreover, can also reduce tumor patient relpase rate, eliminates patient's secondary digestion road and also receive operation.
Experimental example 1
Alimentary canal capsule-type stapler is isolated to the biodegradable no-station pole canopy of embodiment 1-6, carries out degradation property detection,
Specifically detection method is：
By the main body tube of the stapler of precise quality, (quality is denoted as m1) and hemisphere/capsule membrane (quality be note m2),
It is placed in different types of in-vitro simulated degradation solution, under the conditions of 37 DEG C of setting, is slowly shaken in shaking bath, and when specified
Between be spaced, be drawn off, cleaned 4 times using ultra-pure water, be dried under vacuum to constant weight, weigh weight, main body tube quality is denoted as m3, half
The quality of ball/capsule membrane is denoted as m4。
Mass loss rate is calculated as follows：
It is as shown in table 1 that alimentary canal capsule-type stapler degradation situation is isolated in biodegradable no-station pole canopy.
Stapler prepared by 1. embodiment 1 to 6 of table, in-vitro simulated degradation experiment result statistics under different condition
Note *：Degrading experiment 1：Stapler is impregnated wherein, carries out in-vitro simulated degradation by simulated intestinal fluid (pH=5)；
Degrading experiment 2：Simulated intestinal fluid (pH=8) impregnates stapler wherein, and simulated intestinal fluid impregnates degradation.
Claims (1)
1. alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy, it is characterized in that including main body tube (1), the main body tube
It is by mesh skeleton structure sheaf (2) and to be coated on hydrophobic nano fiber film layer (3) group of mesh skeleton structure sheaf (2) outer surface
At being connected separately with hemispherical or half capsule shape Hydrophilic Nanofibrous film at the both ends of main body tube and block (4).
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| CN201720447025.5U CN207886462U (en) | 2017-04-26 | 2017-04-26 | Alimentary canal capsule-type stapler is isolated in biodegradable no-station pole canopy |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106983916A (en) * | 2017-04-26 | 2017-07-28 | 温州生物材料与工程研究所 | Biodegradable no-station pole canopy isolates alimentary canal capsule-type stapler and preparation method |
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2017
- 2017-04-26 CN CN201720447025.5U patent/CN207886462U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106983916A (en) * | 2017-04-26 | 2017-07-28 | 温州生物材料与工程研究所 | Biodegradable no-station pole canopy isolates alimentary canal capsule-type stapler and preparation method |
| CN106983916B (en) * | 2017-04-26 | 2022-04-19 | 温州生物材料与工程研究所 | Biodegradable tension-free isolated alimentary tract capsule type anastomat and preparation method |
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