CN110385438A - A kind of preparation method of the micro- smart biomedical devices of metal embedded type - Google Patents

A kind of preparation method of the micro- smart biomedical devices of metal embedded type Download PDF

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Publication number
CN110385438A
CN110385438A CN201910744020.2A CN201910744020A CN110385438A CN 110385438 A CN110385438 A CN 110385438A CN 201910744020 A CN201910744020 A CN 201910744020A CN 110385438 A CN110385438 A CN 110385438A
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CN
China
Prior art keywords
metal
micro
preparation
biomedical devices
embedded type
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Pending
Application number
CN201910744020.2A
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Chinese (zh)
Inventor
徐晟泰
陈浩琳
陈志扬
陈彬
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Shanghai Jiaotong University
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Shanghai Jiaotong University
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Priority to CN201910744020.2A priority Critical patent/CN110385438A/en
Publication of CN110385438A publication Critical patent/CN110385438A/en
Pending legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/20—Direct sintering or melting
    • B22F10/28—Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/60—Treatment of workpieces or articles after build-up
    • B22F10/66—Treatment of workpieces or articles after build-up by mechanical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/24—After-treatment of workpieces or articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F5/00—Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/30—Process control
    • B22F10/36—Process control of energy beam parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/24—After-treatment of workpieces or articles
    • B22F2003/247—Removing material: carving, cleaning, grinding, hobbing, honing, lapping, polishing, milling, shaving, skiving, turning the surface
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/25—Process efficiency

Abstract

The invention discloses a kind of preparation methods of the micro- smart biomedical devices of metal embedded type, include: metal 3D printing molding, surface of shaped parts assessment and the surface of shaped parts is carried out including ultrasonic cleaning and/or electrochemical polishing treatment, accurate control obtains size smart biomedical devices micro- not higher than 100 μm of metal embedded type.The present invention forms mating surface fine design technology using metal 3D printing, the dimensional accuracy of gained biomedical devices can achieve 50 μm or less, solve the surface defect of the micro- smart instrument of 3D printing straight forming, material surface morphology controllable is realized by adjusting technique, preferably meets biocompatibility.

Description

A kind of preparation method of the micro- smart biomedical devices of metal embedded type
Technical field
The invention belongs to the field of medical instrument technology, and in particular to one kind passes through the micro- essence of 3D printing forming metal embedded type The preparation method of biomedical devices, including 3D printing molding and surface fine treatment process.
Background technique
Currently, subtracting material processing method, the micro- essence doctor of metal 3D printing molding compared to what traditional casting device was cut by laser Treat instrument increases material manufacturing technology can guarantee to substantially reduce production cost in identical mechanics and thermodynamic property, for Some complicated (such as multilayered structures) can not use micro- smart biomedical devices of laser cutting process, and metal 3D can be used The processing of printing shaping technique, dimensional accuracy are high.But constraint and heat affected area effect due to its laser beam spot diameter, it is still difficult With stamp with the size in medical equipments such as 100 μm of metal wires and thin-walled below.
Summary of the invention
For the drawbacks described above for overcoming the prior art, the object of the present invention is to provide a kind of micro- essence biology doctors of metal embedded type The preparation method for treating instrument forms mating surface fine design technology using metal 3D printing, gained biomedical devices Dimensional accuracy can achieve 50 μm hereinafter, the surface defect of the micro- smart instrument of 3D printing straight forming is solved, by adjusting technique reality Existing material surface morphology controllable, preferably meets biocompatibility.
Above-mentioned purpose of the invention is achieved through the following technical solutions:
A kind of preparation method of the micro- smart biomedical devices of metal embedded type, comprising:
I) metal 3D printing molding, comprising steps of
A) with Solidworks to biomedical devices three-dimensional modeling, while Materialize Magics progress is imported Mesh architecture divides, and produces model file；
B) above-mentioned production model file is imported into metal 3D (SLM) printer, with scanning laser to metal powder selectivity Melting successively prints, piles 3D solid instrument rapid shaping；With
II) surface of shaped parts assessment；
III) according to above-mentioned assessment situation to the surface of shaped parts polishing treatment, precise control of sizes；Include:
A) using ultrasonic cleaning polishing treatment, and/or
B) electrochemical polishing treatment is used.
Further, the metal powder includes a kind of in titanium alloy, magnesium alloy or steel and its alloy.
Further, the size of the micro- smart biomedical devices of the metal embedded type is not higher than 100 μm.
Further, the micro- smart biomedical devices of the metal embedded type are metal wire rod or thin-walled, preferably grid type Cardiac stent.
Further, step II) in, the surface of shaped parts is through electron microscope observation and assesses, and assesses parameter and include Particle situation, distribution of pores and the degree apart from editing objective of surface of shaped parts.
Further, the technique of the ultrasonic cleaning polishing treatment is using 8%-10% hydrofluoric acid+15%-20% nitric acid Solution is as acid polishing slurry a, ultrasonic power 80-160W, supersonic frequency 30-130kHz.
Further, the technique of the electrochemical polishing treatment is using 5%-10% perchloric acid alcoholic solution as acid Polishing fluid b, current density 0.5-1.5A/cm2。
In a certain optimal technical scheme, Dispersion on surface particle adheres to more molded part ultrasonic cleaning polishing mode Show compact substance structure to surface nearly smooth or surface, then continues to thin using ultrasonic polishing or electrochemical polish mode Processing observes polishing situation to the electronic scanner microscope of the instrument after polishing, and repeats polishing, realizes to instrument table Face accurately controls.
The micro- smart biomedical devices of the metal embedded type as obtained by above-mentioned preparation method are used in surgical operation to human body device Official career row keeps stablizing or organ is assisted to restore its own function.
Compared with prior art, the beneficial effects of the present invention are:
1) present invention is super by passing through after metal powder laser fusing sintering by selective laser increasing material manufacturing method (SLM) Sound cleaning or electrochemical polishing process make the molding implantation of metal 3D printing with ultrasonic cleaning polishing treatment or electrochemical polish The micro- smart biomedical devices of type realize homogeneous corrosion, it are accurately controlled according to polishing time in 100 μm or less sizes, and to material Material surface accurately controls.
2) subtract material manufacturing method, the micro- smart biologic medical device of the present invention compared to traditional casting device accurate cutting processing The metal 3D printing technique of tool not only has the great advantage in cost and refinement, while being also capable of processing and some can not lead to The workpiece of laser cutting process completion is crossed, 100 μm of preparation or less even 50 μm of bio-medical auxiliary instruments below are suitable for (micropore tissue, metal wire and thin-walled as being suitble to cell attachment, proliferation), realizes more preferably biocompatibility.
Detailed description of the invention
Fig. 1 is the 3D printing molding and its surface fineization processing of the micro- smart biomedical devices of metal embedded type of the present invention Treated electron scanning micrograph.
Fig. 2: (a) be the embodiment of the present invention 1 solidworks modeling figure, be (b) embodiment of the present invention 2 Solidworks modeling figure.
Specific embodiment
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate this Invention, rather than limit the scope of protection of the present invention.Those skilled in the art make according to the present invention in practical applications Modifications and adaptations still fall within protection scope of the present invention.
Embodiment 1
Grid type cardiac stent is printed using EOS-SLM metal 3D printer, is Ti-6Al-4V with powder, Powder size is 0.03mm.
(1) metal 3D printing forms.Technological parameter are as follows: power 165W, scanning speed 800mm/s.
(2) surface fine processing technology, specifically:
Sonochemistry polishing, power 80W, frequency 50kHz ,+20% nitric acid solution ultrasonic polishing 130s of 10% hydrofluoric acid.
Electrochemical polish, voltage 28V, 5% perchloric acid alcoholic solution electrochemical polish 20s.
The model of gained grid type cardiac stent is shown in Fig. 2 (a).
Embodiment 2
A certain bracket is printed using EOS-SLM metal 3D printer, is TC with powder4, powder size is 0.03mm。
(1) metal 3D printing forming technique.Technological parameter: power 190W, scanning speed 1000mm/s.
(2) surface fine processing technology, specifically:
Sonochemistry polishing, power 120W, frequency 80kHz ,+15% nitric acid solution ultrasonic polishing 160s of 8% hydrofluoric acid.
Electrochemical polish, voltage 25V, 10% perchloric acid alcoholic solution electrochemical polish 15s.
The concrete model of a certain bracket of gained is shown in Fig. 2 (b).

Claims (8)

1. a kind of preparation method of the micro- smart biomedical devices of metal embedded type, which is characterized in that comprising steps of
I) metal 3D printing molding, comprising steps of
A) it with Solidworks to biomedical devices three-dimensional modeling, while importing Materialize Magics and carrying out grid point Layer divides, and produces model file；
B) above-mentioned production model file is imported into metal 3D (SLM) printer, metal powder is selectively melted with scanning laser, Successively printing, piles 3D solid instrument rapid shaping；With
II) surface of shaped parts assessment；
III) according to above-mentioned assessment situation to the surface of shaped parts polishing treatment, precise control of sizes；Include:
A) using ultrasonic cleaning polishing treatment, and/or
B) electrochemical polishing treatment is used, size smart biomedical devices micro- not higher than 100 μm of metal embedded type are obtained.
2. preparation method as described in claim 1, which is characterized in that the metal powder includes titanium alloy, magnesium alloy or steel And its one of alloy.
3. preparation method as described in claim 1, which is characterized in that the ruler of the micro- smart biomedical devices of the metal embedded type It is very little to be not higher than 50 μm.
4. preparation method as claimed in claim 1 or 3, which is characterized in that the micro- smart biomedical devices of the metal embedded type For metal wire rod or thin-walled.
5. preparation method as claimed in claim 4, which is characterized in that the micro- smart biomedical devices of the metal embedded type are net Lattice cardiac stent.
6. preparation method as described in claim 1, which is characterized in that step II) in, the surface of shaped parts is through electron microscopic Sem observation is simultaneously assessed, and assesses particle situation, distribution of pores and the degree apart from editing objective that parameter includes surface of shaped parts.
7. preparation method as described in claim 1, which is characterized in that the technological parameter packet of the ultrasonic cleaning polishing treatment It includes: using 8%-10% hydrofluoric acid+15%-20% nitric acid solution as acid polishing slurry a, ultrasonic power 80-160W, ultrasound Frequency is 30-130kHz.
8. preparation method as described in claim 1, which is characterized in that the technological parameter of the electrochemical polishing treatment includes: Using 5%-10% perchloric acid alcoholic solution as acid polishing slurry b, current density 0.5-1.5A/cm2。
CN201910744020.2A 2019-08-13 2019-08-13 A kind of preparation method of the micro- smart biomedical devices of metal embedded type Pending CN110385438A (en)

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CN201910744020.2A CN110385438A (en) 2019-08-13 2019-08-13 A kind of preparation method of the micro- smart biomedical devices of metal embedded type

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110744059A (en) * 2019-11-01 2020-02-04 淮阴工学院 Medical porous low-modulus titanium-magnesium alloy and forming method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9114032B1 (en) * 2014-05-21 2015-08-25 Medtronic Vascular, Inc. Method of making a stent
CN104999078A (en) * 2015-07-16 2015-10-28 广州中国科学院先进技术研究所 Method for preparing false tooth support through 3D printing laser stereo-lithography technology
CN105033252A (en) * 2015-07-23 2015-11-11 南京航空航天大学 Method for preparing shape memory alloy intravascular stent based on automatic powder laying laser combination machining technology
CN106620837A (en) * 2017-01-18 2017-05-10 杨水祥 Manufacturing method for manufacturing magnesium alloy vascular stent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9114032B1 (en) * 2014-05-21 2015-08-25 Medtronic Vascular, Inc. Method of making a stent
CN104999078A (en) * 2015-07-16 2015-10-28 广州中国科学院先进技术研究所 Method for preparing false tooth support through 3D printing laser stereo-lithography technology
CN105033252A (en) * 2015-07-23 2015-11-11 南京航空航天大学 Method for preparing shape memory alloy intravascular stent based on automatic powder laying laser combination machining technology
CN106620837A (en) * 2017-01-18 2017-05-10 杨水祥 Manufacturing method for manufacturing magnesium alloy vascular stent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110744059A (en) * 2019-11-01 2020-02-04 淮阴工学院 Medical porous low-modulus titanium-magnesium alloy and forming method and application thereof

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