CN110384946A - Accurate Chinese medicine frequency modulation is oriented to stew - Google Patents
Accurate Chinese medicine frequency modulation is oriented to stew Download PDFInfo
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- CN110384946A CN110384946A CN201810336649.9A CN201810336649A CN110384946A CN 110384946 A CN110384946 A CN 110384946A CN 201810336649 A CN201810336649 A CN 201810336649A CN 110384946 A CN110384946 A CN 110384946A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0207—Control systems
Abstract
A kind of accurate Chinese medicine frequency modulation pot of orientation, is a sealable container tank, is composed of fangs 1 and cover 2；The cover 2 is that frequency modulation orients intelligent cover, and inside is divided into upper, middle and lower-ranking structure；In the filter screen screen drum 11 that the prepared slices of Chinese crude drugs that orientation is precisely formulated are placed in fangs 1 equipped with stainless steel filter screen screen drum 11 in the fangs 1,300-400 milliliters of boiled water of 90 degree or more are poured into fangs 1, cover cover 2, sensor probe 5 gos deep into liquid, start intelligent control frequency modulation oriented program, automatic running extraction, frequency modulation, oriented program, after the completion of program, drink-service Chinese medicine soup generates frequency modulation in human body and orients quantum effect.Different frequency modulation directional materials 10, since its structure is different from atomic motion frequency, corresponding different quantum entanglement frequency modulation orientation can be generated to the Chinese medicine in fangs 1, the prepared slices of Chinese crude drugs decoction of medicinal ingredients after enabling frequency modulation orients corresponding modern diseases, keeps its clinical efficacy accurate.
Description
Technical field
The present invention relates to Chinese medicinal utensils, and in particular to a kind of to orient prepared slices of Chinese crude drugs frequency modulation orientation, exempt to decoct the orientation essence brewed
Quasi- Chinese medicine frequency modulation stews.
Background technique
Chinese medicine is the general name of Chinese tradition drug, and the prepared slices of Chinese crude drugs are that the shapes such as sheet, bulk, filiform or section section are made in Chinese medicine
The Preparata of shape, because being convenient for decoction drink-service due to referred to as medicine materical crude slice.The prepared slices of Chinese crude drugs are the main means that Chinese medicine is cured the disease, but long-term
Since, the prepared slices of Chinese crude drugs, which exist, boils medicine that difficult, dosage is big, curative effect not enough accurately limitation.In recent years the new technology of prepared slices of Chinese crude drugs reform,
There are Chinese medicinal granule medicine materical crude slice and super-micro wall-broken medicine materical crude slice, the former changes the composition of the prepared slices of Chinese crude drugs with extraction process, and the latter uses super
The Crushing of Ultrafine process reform form of the prepared slices of Chinese crude drugs, does not meet one ministerial standard of the Pharmacopoeia of the People's Republic of China, and cost
Height, medicinal material waste is big, and the accurate problem of curative effect is still unresolved.Prepared slices of Chinese crude drugs composition can not be changed, do not change prepared slices of Chinese crude drugs state,
Do not increase prepared slices of Chinese crude drugs treatment cost, and the prepared slices of Chinese crude drugs processing unit (plant) of synergy, the blank still to remain to be filled can be reduced.
Summary of the invention
The purpose of the present invention is to boil medicine that difficult, dosage is big, curative effect not enough accurately problem for the prepared slices of Chinese crude drugs, proposes one kind
Accurate Chinese medicine frequency modulation is oriented to stew.
The purpose of the present invention is what is realized with following technical proposals:
The present invention orients accurate Chinese medicine frequency modulation and stews, and is a sealable container tank, orients intelligent tank by fangs 1 and frequency modulation
Lid 2 is composed.
The cover 2 is that frequency modulation orients intelligent cover, and inside is divided into upper, middle and lower-ranking structure: the middle layer,
Intelligent controlling device 3 is arranged in side, and frequency modulation orienting device 4 is arranged in the other side.Intelligent controlling device 3 includes vlsi circuitry plate
6 and battery 7.Frequency modulation directional material 10 is equipped among the intelligent controlling device 3 and frequency modulation orienting device 4, frequency modulation orients material
Material 10 is the single compound for acting on biological acceptor, composition or biological products, i.e., has accurate adjustment effect to biological acceptor
Pharmacological active substance；Frequency modulation directional material 10 also added with light quantum carrier mass, that is, tourmaline powder, frequency modulation directional material 10 with
The conjugation of intelligent controlling device 3 generates frequency modulation orientation.The lower layer is provided with sensor probe 5 and one or several logical
To the hole pipe 9 in middle layer.Long 2-5 centimetres of sensor probe 5, is protruded into fangs 1.Live wire by the signal of sensor probe 5 with
Vlsi circuitry plate 6 connects.Waterproof ventilated membrane is stamped on hole pipe 9, waterproof permeable membrane is the waterproof membrane that aperture is 1nm-1um, institute
The micropore for the waterproof ventilated membrane stated, it is waterproof while can also serve as quantum effect channel, material and device in cover 2 occurs
Quantum wave energy and fangs 1 in Chinese medicine brewing liquid generate quantum effect, realize frequency modulation orient synergistic effect；After covering cover 2,
The frequency modulation directional material 10 has the distance of 3cm or more away from the Chinese medicine in fangs 1.The upper layer is provided with voice broadcast dress
Set 8, display indicator light 12 and power switch 13.
The sound broadcasting device 8 and 7 live wire of battery are connect with vlsi circuitry plate 6.
The fangs 1 is the stainless steel or ceramics or plastics tank body for having heat insulation function.It is filtered in fangs 1 equipped with stainless steel
Mesh screen cylinder 11 filters the prepared slices of Chinese crude drugs dregs of a decoction when convenient Chinese medicine materical crude slice brews.Sensor probe 5 in the cover 2 is inserted in
In stainless steel filter screen screen drum 11.
Application method of the invention is: the filter screen screen drum 11 prepared slices of Chinese crude drugs that orientation is precisely formulated being placed in fangs 1
It is interior, it is placed in fangs 1,300-400 milliliters of water of 90 DEG C or more is poured into fangs 1, cover cover 2, keep sensor probe 5 deep
Enter in liquid, start intelligent control knob, starts intelligent control frequency modulation oriented program, prompted according to voice broadcast, program automatic running
Extraction, frequency modulation, oriented program.When program is completed, cover 2 is opened after automatic alarm, pours out soup in fangs, and when warm slowly drinks
It is complete, it is 2-3 times daily.
Action principle of the invention is: prepared slices of Chinese crude drugs boiled water brews cover cover 2 after, startup program, sensor probe 5 feel
Induction signal is in the perceived identification of integrated circuit, and by intelligent control voice broadcast, temperature sense in audio frequency vibration and fangs 1 swashs
Frequency modulation directional material 10 more among intelligent controlling device 3 and frequency modulation orienting device 4 generates quantum and is in harmony effect, then throughput altogether
Sub- effect access opening pipe 9 is in harmony altogether with sensor probe 5, is acted on low-temperature extraction in fangs 1 and is oriented accurate prepared slices of Chinese crude drugs soup, altogether
Yoke generates quantum effect, orients to the Chinese medicine frequency modulation in fangs 1, after tank body completes extraction, frequency modulation oriented program, drink-service Chinese medicine
Soup generates frequency modulation in human body and orients quantum effect.Different frequency modulation directional material 10, due to its structure and atomic motion frequency
Difference can generate corresponding different quantum entanglement frequency modulation orientation, the prepared slices of Chinese crude drugs soup after making frequency modulation to the Chinese medicine in fangs 1
Medicine can orient corresponding modern diseases, keep its clinical efficacy accurate.
The beneficial effect comprise that
1, it realizes that the prepared slices of Chinese crude drugs exempt to decoct to brew to take, solves Traditional Chinese medicine decocting problem, convenient Chinese medicine materical crude slice uses.
2, it is oriented by frequency modulation and realizes that Chinese medicine orients modern diseases, clinical efficacy is accurate, makes Chinese medicine by modern disease for the first time
Sick standard precisely reaches standardization curative effect.
It 3, is multiple target point composition after prepared slices of Chinese crude drugs extraction, single target spot composition that frequency modulation intense can orient disease and act on is formed
Traditional Chinese Medicine dosage is greatly reduced by frequency modulation orientation, it is demonstrated experimentally that orienting the accurate prepared slices of Chinese crude drugs in new monarch compatibility relationship
Effective dose and small 20 times of traditional Chinese medicine medicine materical crude slice effective dose or more, show that Chinese medicine can be greatly lowered by orienting accurate Chinese medicine
Cost.
4, accurate Traditional Chinese Medicine dosage is oriented by frequency modulation orientation and (20 times or more) is greatly reduced than traditional Chinese medicine dosage, simultaneously
The toxic side effect risk for orienting accurate Chinese medicine is also equally greatly lowered than traditional Chinese medicine.
5, simplifying for accurate Traditional Chinese Medicine dosage is oriented by frequency modulation, can also significantly saves Chinese herbal medicine cultivated area,
Cultivated land occupancy is reduced, and reduces Chinese medicine process pollution environment, is conducive to ecological, environmental protective.
Detailed description of the invention
Fig. 1 present invention orients accurate Chinese medicine frequency modulation and stews schematic diagram
In figure: 1, fangs, 2, cover, 3, intelligent controlling device, 4, frequency modulation orienting device, 5, sensor probe, 6, integrated
Circuit board, 7, battery, 8, sound broadcasting device, 9, Kong Guan, 10, frequency modulation directional material, 11, filter screen screen drum.
Specific embodiment
Embodiment 1
Principle according to the present invention, easy making orient accurate Chinese medicine preparation facilities and orient Chinese Traditional Medicine Boiler, with injection mold, often
Shooting Technique, PP environmental protection plastic are advised, the plastic circular sealing container of volume 630ml is made in injection molding.Inner wall 1Cr14Mn10Ni1+
PP stainless steel plate.Sealing container is made of fangs 1 and cover 2, and cover 2 divides upper, middle and lower-ranking structure, and lower layer diameter 10cm is high
Spend 8cm；It is provided with sensor probe 5 and a diameter 0.01-0.2cm leads to the hole pipe 9 in middle layer, long 2-5 lis of sensor probe 5
Rice, is protruded into fangs 1, the signal of sensor probe 5 is connect by live wire with vlsi circuitry plate 6.It is stamped on hole pipe 9 anti-
Water ventilated membrane, waterproof ventilated membrane are the waterproof membranes that aperture is 1nm-1um micropore, and the micropore of waterproof ventilated membrane is waterproof to be can also serve as
Quantum effect channel；Intelligent controlling device 3 is arranged in middle layer diameter 10cm, height 2cm, side, and the other side is arranged frequency modulation and orients dress
Set 4.Intelligent controlling device 3 includes vlsi circuitry plate 6 and battery 7.Among intelligent controlling device 3 and frequency modulation orienting device 4
It is equipped with the blood pressure lowering frequency modulation directional material 10 loaded in 1nm-1um diameter micropore bag, 10 light quantity subcarrier light of frequency modulation directional material
Wavelength 6-14um covers the distance that frequency modulation directional material 10 after cover 2 has 3-6cm away from Chinese medicine in fangs 1；Upper layer is provided with voice
Broadcast device 8 shows indicator light 12 and power switch 13, and voice is write into sound broadcasting device 8 and broadcasts program automatically and falls to count
Shi Chengxu and 7 live wire of battery are connect with vlsi circuitry plate 6.
Stainless steel filter screen sieve is inserted in equipped with the sensor probe 5 in 11 cover 2 of stainless steel filter screen screen drum in fangs 1
In cylinder 11.
Cover 2 is connected by spiral interface fangs 1, forms sealing container after screwing.
Clinical test of the present invention presses GLP by Hunan Inst of Traditional Chinese Medicine affiliated hospital, national Bureau of Drugs Supervision's clinical trial mechanism
Standard carries out Clinical efficacy comparison verifying, as a result as follows:
One, clinical test purpose
By comparing conventional prepared slices of Chinese crude drugs decocting method, verifies the present invention and brew accurate prepared slices of Chinese crude drugs treatment wind sun rising type
The health giving quality of hypertension, and be compared with conventional prepared slices of Chinese crude drugs curative effect, evaluate the effectiveness and reliability of its clinical application.
Two, clinical testing procedure
This clinical test is designed using random, the positive parallel check experiment of layering district's groups.
(1) test method selection and its reason
This clinical test can effectively exclude Confounding Factor pair using classical randomized controlled trial design, the design
The interference of test result, the balanced comparativity of guarantee test group and control group.It was counted before on-test by data statistics mechanism
Software generates district's groups randomizing scheme, and the enrolled order of subject is randomly assigned respectively during test, into test group or control
Group.Control group and test group are distributed according to 1:1.
(2) control design and reason
The control group conventional prepared slices of Chinese crude drugs, the prescription of traditional Chinese medical science great master Zhou Zhongying, by uncaria 15g, Rhizoma Gastrodiae 10g, cassia seed
12g, wild chrysanthemum 10g, Folium Apocyni Veneti 15g, mother-of-pearl 30g, radix scrophulariae 10g, Chinese herbaceous peony vehicle 10g, clerodendron trichotomum 15g , Common St.Paulswort Herb 15g are white
Puncture vine 15g, periostracum cicada 10g, radix gentianae 15g, rheum officinale 15g composition dose are one dose per day dosage.Suitable for the high blood of wind sun rising type
The treatment of pressure.
(3) reduce, avoid the measure of bias
1. test is all observed in veteran pharmacology base, condition and equipment, people with perfect clinical test
Member is equipped with.
2. proving before test by detail discussion and ethics, project has the feasibility of height.
3. test products mechanism is mature, it is able to satisfy the clinical demand of patient.Test uses positive control, and with random side
Method is observed.It avoids testing the bias generated in group.
4. test process is operated and is observed by the doctor Jing Guo professional training, and carries out preclinical training to observer
Instruction guarantees the consistency during observing and reduces bias.
5. having complete data administrator after the test, guarantee the objectivity of data processing.
Three, clinical test content
The accurate prepared slices of Chinese crude drugs are brewed using the present invention and implement treatment, observe and compare two groups of patient's feelings for the treatment of group and control group
Condition.
It brews in accurate prepared slices of Chinese crude drugs application process and is observed to demographic data, disease before and after subject in the present invention
Symptom characteristic, health giving quality observation index, therapeutic process carry out exquisite detail, control and management, carry out clinical statistics and assessment, out
Has clinical experiment report.
Four, clinical general information
(1) trial stretch disease
Suitable for the patient of wind sun rising type high blood pressure (1-2 grades), doctor trained in Western medicine depressor is deactivated.By special material and double
Layer structure, the orientation storage synergy prepared slices of Chinese crude drugs, and be compared with conventional prepared slices of Chinese crude drugs curative effect.
(2) selection of case
Inclusion criteria
It is all to meet following full terms person, it can be included in observe case:
(1) " informed consent form " is signed, volunteered tested；
(2) age between 18~75 one full year of life, male or female；
(3) it is diagnosed as 1,2 grade of hypertensive patient of wind sun rising type；
(4) hyperpiesia, 3 surveys are not pressed on the same day in 1 week, and blood pressure reaches diagnostic criteria person；
(5) non-medication, or take hypertension drug but drug withdrawal the latter.
Exclusion criteria
The one for having following items can not be included in observation case:
(1) discovery does not meet and is included in standard person after being included in, or the person that meets exclusion criteria；
(2) row does not treat or without any test data sheet person after the allocated number；
(3) researcher thinks to continue to participate in this clinical trial investigator (need to give reasons).
(3) calculating of sample size
This test uses random controls, Noninferior solution experimental design.It is that evaluation index is estimated using following formula with effective percentage
Sample size needed for meter is tested:
N=2 × (Z1-α+Z1-β/2)2×π(1-π)/Δ2
Wherein α=0.05 (unilateral side), β=0.2, Z1-a=1.64, Z1-B=0.85, efficient π conservative estimation is 95%, non-
Bad effect dividing value Δ is taken as -15%, calculates gained sample size N ≈ 26, consider 15% potential unqualified case or fall off, increase
Sample size guarantees final inspection efficiency to 30.Subject 30 are respectively completed for each indication test group and control group,
It is total to complete subject 60.
(4) case load
Testing number of cases is 72.Reason is as follows:
(1) according to the actual conditions of the standard empirical of medical institutions and subject source；
(2) according to statistical calculations, it is contemplated that have partial exfoliation case during test, therefore enter a group disease for increase by 20%
Example, i.e. totally 36 cases.Test group and control group ratio are 1:1, therefore testing total number of cases is 72.
Five, test medical product and control medical product/control diagnosis and treatment method
(1) medical product is used in test
The present invention brews the accurate prepared slices of Chinese crude drugs.
Application method: the accurate prepared slices of Chinese crude drugs are brewed using the present invention.Accurate prepared slices of Chinese crude drugs prescription: hook is brewed using the present invention
Rattan 2g, cassia seed 2g, wild chrysanthemum 2g, Folium Apocyni Veneti 1g.Application method: the accurate prepared slices of Chinese crude drugs are weighed by quantity calculating on the 7th
(49 grams of total amount) when taking, is added 100 DEG C of boiled water 300ml or so (not filling) with the present invention and brews, lid must be covered tightly when brewing
Son starts present procedure, completes program, then the Chinese medicine soup of drink-service bubble punching.It brews and drinks 2 times per the daily present invention.
(2) control medical product/control diagnosis and treatment method
For the conventional prepared slices of Chinese crude drugs, using the prescription of traditional Chinese medical science great master Zhou Zhongying, by uncaria 15g, Rhizoma Gastrodiae 10g, cassia seed 12g,
Wild chrysanthemum 10g, Folium Apocyni Veneti 15g, mother-of-pearl 30g, radix scrophulariae 10g, Chinese herbaceous peony vehicle 10g, clerodendron trichotomum 15g , Common St.Paulswort Herb 15g, tribulus terrestris
15g, periostracum cicada 10g, radix gentianae 15g, rheum officinale 15g composition dose are that one dose per day dosage is 28 times for orienting the accurate dosage of drug.
Treatment suitable for wind sun rising type hypertension.
Application method: with conventional prepared slices of Chinese crude drugs prescribed dose, being decocted in water for oral dose, and daily one is secondary, can be divided into 2 and take.
Six, used statistical analysis technique and evaluation method
(1) statistical analysis technique
1, crowd is analyzed
(1) it complete analysis collection (full analysis set, FAS): to all through randomized grouping, and at least takes primary
The all cases of drug, will be wherein it is observed that the case-data of whole therapeutic process, not be carried down with last time observation data
To test final result, intentional analysis is carried out to curative effect and adverse events incidence.
(2) meet scheme collection (per protocol set, PPS): all Pass Test schemes, compliance be good, experimental period
Between do not take and forbid medication, complete CRF and provide the case of fill substance, it is right or using test products quantity in 80%-120% person
Its curative effect is for statistical analysis.
(3) safety data collection (safety analysis set, SAS): including it is all at least receive seance by
Examination person carries out statistics description and analysis to safety indexes and adverse reaction rate.
2, statistical analysis technique
(1) the harmonious analysis of basic value:
Measurement data will carry out statistics description using mean ± standard deviation, and two comparison among groups are examined using t or median inspection
Test progress；Enumeration data carries out statistics description using frequency (composition ratio), and two group differences use χ2Examine or rank sum test into
Row.
(2) efficiency analysis:
Curative effect index measurement data will carry out statistics description using mean ± standard deviation.It is compared to use with baseline value and match
T is examined；Two groups of pretherapy and post-treatment variations are examined using t or median test is compared.Enumeration data is constituted using frequency
Than carrying out statistics description.Two comparison among groups use χ2Inspection or rank sum test.
(3) safety analysis:
A situation arises carries out statistics description using frequency (composition ratio) for adverse events and adverse reaction, and two group differences use
χ2It examines, and list describes this test adverse events occurred and the judgement with clinical test drug-associated.
(2) statistical appraisal method
Validity terminal
Calculating test group treats the curative effect of hypertension, a=0.05, if P > 0.05, then it is assumed that two groups of treatments with set product is compareed
Imitate no significant difference.
The processing of missing values and exceptional value
Estimation to primary variables missing values, using closest to the result once observed carry down (carry-forward) arrive
At test data missing, each group is consistent when evaluating number of subjects and the on-test of curative effect in terminal.
It does not fill out or wrong data need to search initial data and be refilled or be corrected.
Seven, clinical evaluation standard
(1) efficiency evaluation standard
1, main indicator
Blood pressure efficacy assessment standard
It is effective: 1. diastole drops 10mmHg or more, and reach normal range (NR)；2. under though diastolic pressure does not drop to normally but
20mmHg or more drops.
Effective: 1. diastole drops are not as good as 10mmHg, but have reached normal range (NR)；2. diastole drops 10-19mmHg, but
Not up to normal range (NR)；3. systolic pressure declines 30mmHg or more before relatively treating.Must have wherein 1.
It is invalid: the not up to above standard person.
2, secondary index
Related symptoms sign efficacy assessment standard
Effective: clinical symptoms, sign are obviously improved, and integral reduces >=70%.
Effective: clinical symptoms, sign take a favorable turn, and integral reduces >=30%.
Invalid: clinical symptoms, sign are not improved, even aggravating, integral is reduced less than 30%.
Note: Nimodipine method: curative effect percentage=[(pre-treatment score-post treatment integral)/pre-treatment score] ×
100%.
(2) safety evaluation standard
1, main indicator
With adverse reaction rate for main safety indexes.
2, secondary index
A. vital sign (breathing, heart rate, blood pressure, body temperature etc.).
B. a situation arises for adverse events and adverse reaction.
Eight, clinical test results
This clinical test enters 72 subjects of group altogether, and nothing falls off or rejects case in test, and actually accomplishing case load is
72, test group and control group case load ratio are 1:1.
(1) case enters group and completes
1 each center enters group and performance
1. case of table enters group and analysis of performance (example, %)
Patient chart in 2 each data sets
2. data set situation analysis of table (example, %)
(2) baseline analysis
1, demographic data's (summary)
The no statistical differences such as the demographic data of two groups of subjects such as gender, age, marriage, nationality, height, weight meaning
Adopted (P > 0.05) has preferable comparativity.
2, general vital signs (summary)
Subject treat it is previous as vital signs such as breathe, heart rate, body temperature group difference it is not statistically significant (P >
0.05), there is preferable comparativity.
3, the basic state of an illness data of subject
The basic state of an illness data of two groups of subjects such as hypertension measured value and classification situation, physical examination situation, drug combination
And merge the equal nothing of group differences such as classification situation before disease event, drug allergy situation, Chinese medicine syndrome integral and related symptoms are treated
Statistical significance (P > 0.05) has preferable comparativity.
3 subject's physical examination situation analysis (example, %) of table
4 diagnosis situations
4 doctor trained in Western medicine of table diagnoses situation analysis (example, %)
Situation analysis (example, %) is demonstrate,proved in 5 wind sun rising of table
5 medicining conditions
The current medicining condition of table 6 analyzes (example, %)
Table 7 period medicining condition analyzes (example, %)
The current drug combination situation inventory of table 8
(6) merge disease and treatment
Table 9 merges disease event analysis (example, %)
Table 10 merges disease and curer's inventory
(7) drug allergy history
11 drug allergy history situation analysis of table (example, %)
(8) blood pressure
Blood pressure situation analysis mmHg before 12 subject of table treats
(9) Chinese medicine syndrome integral
Chinese medicine syndrome integral situation analysis before 13 subject of table treats
(10) tcm syndrome related symptoms are classified
Tcm syndrome related symptoms are classified situation analysis before 14 subject of table treats
(3) efficiency analysis
The obvious effective rate that test group treats hypertension is 52.78%, total effective rate 91.67%；Control group obvious effective rate is
47.22%, effective percentage is 91.67%, and the Different therapeutical effect of two groups for the treatment of hypertension is not statistically significant (P > 0.05).
After the course for the treatment of, it is 18.44 ± 8.37mmHg that test group, which receives pressure mean decrease, and diastolic pressure drop-out value is 13.95
±8.18mmHg；Control group systolic pressure mean decrease be 16.74 ± 10.37mmHg, diastolic pressure drop-out value be 16.13 ±
8.38mmHg, decline before blood pressure is relatively treated after two groups of subjects, the statistically significant P < 0.05 of difference, two groups of contractions
Pressure and diastolic pressure fall group difference are not statistically significant (P > 0.05).
1, blood pressure curative effect
15 blood pressure curative effect situation analysis (example, %) of table
2, situation of change before and after blood pressure medication
The pretherapy and post-treatment situation of change of 16 systolic pressure of table analyzes mmHg
The pretherapy and post-treatment situation of change of 17 diastolic pressure of table analyzes mmHg
3, tcm syndrome therapeutic evaluation
The obvious effective rate of test group tcm syndrome curative effect is 83.33%, total effective rate 100.0%, and control group obvious effective rate is
66.67%, total effective rate 100.0%, two groups of tcm syndrome Different therapeutical effects are not statistically significant (P > 0.05).
18 tcm syndrome curative effect situation analysis (example, %) of table
19 total effective rate situation analysis of table (example, %)
4, the pretherapy and post-treatment situation of change analysis of Chinese medicine syndrome integral
Decline before two groups of Chinese medicine syndrome integrals are relatively treated after the course for the treatment of, difference is statistically significant (P < 0.05), and two groups
Between fall no significant difference (P > 0.05).
The pretherapy and post-treatment situation of change analysis of 20 Chinese medicine syndrome integral of table
5, exception person improves situation before tcm syndrome related symptoms are treated
Each symptom and sign such as dizziness after the course for the treatment of, irritable, flushing, hot eyes, dry, bitter taste, constipation, is urinated at headache
Red wait is effectively improved, and group difference is not statistically significant (> 0.05).
21 dizziness of table improves situation analysis (example, %)
The headache of table 22 improves situation analysis (example, %)
23 irritable of table improves situation analysis (example, %)
The flushing improvement situation analysis (example, %) of table 24
25 hot eyes of table improves situation analysis (example, %)
26 dry of table improves situation analysis (example, %)
27 bitter taste of table improves situation analysis (example, %)
28 constipation of table improves situation analysis (example, %)
Table 29 is urinated red improvement situation analysis (example, %)
Nine, clinical test results analysis, discussion, especially indication, the scope of application, contraindication and points for attention
This clinical test is total to enrolled subject 72, test group and control group each 36, without falling off or reject in test
Case, actually accomplishing case load is 72.
This test subject derives from clinic case, and subject basic population learns data (gender, wedding condition, age, body
Height, weight etc.), the breathing of general vital signs, heart rate, body temperature, basic state of an illness data (such as hypertension measured value and classification situation,
Physical examination situation, drug combination and merging disease event, drug allergy situation, Chinese medicine syndrome integral and related symptoms are divided before treating
Grade situation) etc. group differences it is not statistically significant (P > 0.05), therefore be believed that this test subject's Baseline Data is balanced, tool
There is preferable comparativity.
The obvious effective rate that test group (dosage is 28 times small compared with control group) treats hypertension is 52.78%, and total effective rate is
91.67%；Control group (dosage is 28 times bigger than test group) obvious effective rate is 47.22%, and effective percentage is 91.67%, and two groups are controlled
The Different therapeutical effect for treating hypertension is not statistically significant (P > 0.05).
After the course for the treatment of, test group systolic pressure mean decrease is 18.44 ± 8.37mmHg, and diastolic pressure drop-out value is
13.95±8.18mmHg；Control group systolic pressure mean decrease is 16.74 ± 10.37mmHg, and diastolic pressure drop-out value is 16.13
± 8.38mmHg, decline before blood pressure is relatively treated after two groups of subjects, difference is statistically significant (P < 0.05), and two groups
Systolic pressure and diastolic pressure fall group difference are not statistically significant (P > 0.05).
The obvious effective rate of test group tcm syndrome curative effect is 83.33%, total effective rate 100.0%, and control group obvious effective rate is
66.67%, total effective rate 100.0%, two groups of tcm syndrome Different therapeutical effects are not statistically significant (P > 0.05).After the course for the treatment of
Decline before two groups of Chinese medicine syndrome integrals are relatively treated, difference is statistically significant (P < 0.05), and fall difference is without system between two groups
Meter learns meaning (P > 0.05).Each symptom and sign such as dizziness, headache, irritable, flushing, hot eyes, dry, mouth after the course for the treatment of
Hardship, constipation, urinate it is red etc. be effectively improved, group difference is not statistically significant (> 0.05).
It finds no during test products and reference product test using defect.
Occur in test without adverse events/adverse reaction, use is safe.
Indication: wind sun rising type hypertension
Contraindication: nothing.
Ten, clinical test conclusion
The present invention brews on the accurate prepared slices of Chinese crude drugs (uncaria 2g, cassia seed 2g, wild chrysanthemum 2g, Folium Apocyni Veneti 1g) treatment wind sun
High type hypertension, with control group (the conventional prepared slices of Chinese crude drugs: uncaria 15g, Rhizoma Gastrodiae 10g, cassia seed 12g, wild chrysanthemum 10g, Folium Apocyni Veneti
15g, mother-of-pearl 30g, radix scrophulariae 10g, Chinese herbaceous peony vehicle 10g, clerodendron trichotomum 15g , Common St.Paulswort Herb 15g, tribulus terrestris 15g, periostracum cicada 10g, radix gentianae
15g, rheum officinale 15g, daily dosage orient 28 times of the accurate prepared slices of Chinese crude drugs).Patients' blood can be effectively reduced, preferably in therapeutic equivalence
Ground improves patient's dizziness, headache, irritable, flushing, hot eyes, dry, bitter taste, constipation, the symptoms such as red of urinating, easy to operate, makes
With safety without defect is obviously used, it is able to satisfy clinical demand, is suitble to clinical application.
Embodiment 2
Principle according to the present invention, easy making orient accurate Chinese medicine preparation facilities and orient Chinese Traditional Medicine Boiler, with injection mold, often
Shooting Technique, PP environmental protection plastic are advised, the plastic circular sealing container of volume 630ml is made in injection molding.Inner wall 1Cr14Mn10Ni1+
PP stainless steel plate.Sealing container is made of fangs 1 and cover 2, and cover 2 divides upper, middle and lower-ranking structure, and lower layer diameter 10cm is high
Spend 8cm；It is provided with sensor probe 5 and a diameter 0.01-0.2cm leads to the hole pipe 9 in middle layer, long 2-5 lis of sensor probe 5
Rice, is protruded into fangs 1, the signal of sensor probe 5 is connect by live wire with vlsi circuitry plate 6.It is stamped on hole pipe 9 anti-
Water ventilated membrane, waterproof ventilated membrane are the waterproof membranes that aperture is 1nm-1um micropore；The micropore of waterproof ventilated membrane is waterproof to be can also serve as
Quantum effect channel；Intelligent controlling device 3 is arranged in middle layer diameter 10cm, height 2cm, side, and the other side is arranged frequency modulation and orients dress
Set 4.Intelligent controlling device 3 includes vlsi circuitry plate 6 and battery 7.Among intelligent controlling device 3 and frequency modulation orienting device 4
It is equipped with the antipyretic frequency modulation directional material 10 loaded in 1nm-1um diameter micropore bag, 10 light quantity subcarrier light wave of frequency modulation directional material
Long 6-14um, after covering cover 2, frequency modulation directional material 10 has the distance of 3-6cm away from Chinese medicine in fangs 1；Upper layer is provided with voice
Broadcast device 8 shows indicator light 12 and power switch 13, and voice is write into sound broadcasting device 8 and broadcasts program automatically and falls to count
Shi Chengxu and 7 live wire of battery are connect with vlsi circuitry plate 6.
Stainless steel filter screen sieve is inserted in equipped with the sensor probe 5 in 11 cover 2 of stainless steel filter screen screen drum in fangs 1
In cylinder 11.
Cover 2 is connected by spiral interface fangs 1, forms sealing container after screwing.
It is oriented in Chinese Traditional Medicine Boiler fangs 1 in use, common traditional Chinese medicine medicine materical crude slice is packed into the present apparatus, screws cover 2, form sealing
Container sets common traditional Chinese medicine medicine materical crude slice in 1-12 hours in sealing container, is prepared into the antipyretic accurate prepared slices of Chinese crude drugs of orientation.
The present invention orients accurate Chinese medicine Yinqiao San refrigeration function comparative experiments and is tested by Chinese department of traditional Chinese medicine institute Chinese medicine, real
It is as follows with result to test data:
The preparation of ■ traditional Chinese medicine medicine materical crude slice Yinqiao San addition and subtraction
Prescription: honeysuckle flower 12g, Fructus Forsythiae 12g, campanulaceae 9g, peppermint 3g, Jing Jie 6g, public English 12g, leaf of bamboo 9g, moxibustion mulberry skin 9g, sweet
Careless 5g, reed root 15g, mulberry leaf 12g, chrysanthemum 9g, caulis akebiae 3g, radix scutellariae 9g, gallbladder grass 6g.
Recipe quantity is 137 grams.
Preparation method: the above recipe quantity is decocted 1 hour by 10 times of water, and the dregs of a decoction use 8 times of water to decoct half an hour again, boil liquid will be closed twice
And it is concentrated into corresponding administration concentration.Concentration is respectively as follows: 312% (referring to contained crude drug amount g in 100ml, similarly hereinafter), 156%, 78%.
Mouse dose: low dose of 15.60g/kg, middle dosage 31.20g/kg, large dosage 62.40g/kg；
Rat dosage: low dose of 7.80g/kg, middle dosage 15.60g/kg, large dosage 31.20g/kg.
The ■ present invention orients the preparation of accurate prepared slices of Chinese crude drugs Yinqiao San test sample
Prescription: honeysuckle flower 2g, Fructus Forsythiae 2g, peppermint 1g, Jing Jie 1g.
Recipe quantity is 6 grams.
Preparation method:
Above-mentioned 4 taste medicine medicine materical crude slice is crushed；
Powder is installed with ventilative Chinese herbal medicine bag and (is provided ventilative Chinese herbal medicine bag by enterprise)；
By Chinese medicine in ventilative Chinese herbal medicine bag (containing bag)；Be put into present invention orientation Chinese Traditional Medicine Boiler, cover tightly lid, place 24 hours with
On.
Ventilative Chinese herbal medicine bag is taken out out of the present invention orientation Chinese Traditional Medicine Boiler when experiment, weighs the prepared slices of Chinese crude drugs by test dose from bag
Powder puts it into present invention orientation Chinese Traditional Medicine Boiler, is brewed with boiled water, cover tightly lid, brew soaking time 1 hour.
Orientation Chinese Traditional Medicine Boiler brew after Chinese medicine will Chinese herbal medicine bag be put into wherein, room temperature storage.Concentration is respectively as follows: 14%, 7%,
3.5%.
Mouse dose: low dose of 0.70g/kg, middle dosage 1.40g/kg, large dosage 2.80g/kg；
Rat dosage: low dose of 0.35g/kg, middle dosage 0.70g/kg, large dosage 1.40g/kg.
2. testing article
■ aspirin
Aspirin is classical analgesic-antipyretic Western medicine, and antipyretic effect is stablized, and preparation selects aspirin
Effervescent tablet (Ba meter Er)；, produced for AstraZeneca pharmaceutical Co. Ltd, lot number 1601225.Adult daily dosage is 2 grams, is pressed
60kg/ people, i.e., artificial 0.033 gram/kg weight.It is converted by animals and human beings kg body weight equivalent dose, rat 0.18g/kg body
Weight, mouse 0.36g/kg weight, are equivalent to the daily dosage of clinical equivalent.
■ animal
SD rat 232, SPF grades, 160~180g of weight, half male and half female；ICR mouse 340, SPF grades, weight 18~
20g, it is female 260,80 male, it is purchased from Beijing Vital River Experimental Animals Technology Co., Ltd., licensing number SCXK (capital)
2012-0001.Raising uses credit number SYXK (capital) in barrier environment, experimental animal；2013-0035, the scope of application are screen
Hinder grade mouse, rat, cavy, rabbit, validity period is on December 25,25 days to 2018 December in 2013.Animal feed is that SPF is big
Mouse maintain feed, by Beijing Australia, section pull together feed corporation,Ltd provide, batch number 16103213, the date of manufacture
20161015, the shelf-life is six months.
■ reagent
Angel high activity dried yeast, Anqi Yeast's product, date of manufacture 22/08/2016, validity period
To 21/08/2018.Glacial acetic acid, Sinopharm Chemical Reagent Co., Ltd.'s product, lot number 20150704.
■ instrument
MC-347 type electronic thermometer (anus temperature), Omron's production.RCY-2 hot plate pain threshold detector, Ji Xing experiment
Instrument Ltd.'s production.
■ experimental group situation
Experiment is divided into 8 groups, and respectively blank control group, aspirin group, traditional Chinese medicine medicine materical crude slice Yinqiao San addition and subtraction group is high
In low three groups, accurate high, normal, basic three groups of prepared slices of Chinese crude drugs Yinqiao San of orientation.
■ statistical procedures
Experimental data uses mean ± standard deviationIt indicates, with Excel software, is carried out between group using the t method of inspection
Difference
Different comparison
■ experimental method and result
The influence [1,2] of rat fever body temperature is caused to yeast
Take SD rat 116, half male and half female, 160~180g of weight.It tests the same day and surveys animal anus temperature twice, with average temperature
Degree is as basic anus temperature.With 15% dry ferment suspension dorsal sc injection (2ml/100g weight) pyrogenicity, surveyed after 4.5 hours
Anus temperature takes anus temperature to increase the animal between 0.8~2.0 DEG C for testing.It is grouped at random with anus temperature rise high level, totally 8 groups, respectively
Blank control group, aspirin group (0.18g/kg), traditional high, normal, basic three groups of medicine materical crude slice Yinqiao San addition and subtraction group (31.20,
15.60,7.80g crude drug/kg) and using the present invention orient accurate high, normal, basic three groups of medicine materical crude slice Yinqiao San (1.40,0.70,
0.35g crude drug/kg), every group 10, half male and half female.Same volume is given in gastric infusion, 1ml/100g weight, control group stomach-filling
Distilled water.It 1 after medicine, respectively surveys anus temperature once within 2,4 hours, records the surveyed anus temperature value (DEG C) of different time points, and and basal body temperature
Compare, calculate each time point Temperature changing value (Δ T, DEG C), experiment is repeated once with method.It the results are shown in Table 30,31.
30 traditional Chinese medicine medicine materical crude slice Yinqiao San addition and subtraction of table and the present invention orient accurate prepared slices of Chinese crude drugs Yinqiao San and cause greatly to yeast
Mouse generate heat body temperature influence (It tests for the first time)
Note: compared with the control group, p < 0.01 * *.
31 traditional Chinese medicine medicine materical crude slice Yinqiao San addition and subtraction of table and the accurate prepared slices of Chinese crude drugs Yinqiao San of orientation
To yeast cause rat fever body temperature influence (Second of experiment)
Refrigeration function.
The present invention orients accurate prepared slices of Chinese crude drugs Yinqiao San by 4 taste Chinese medicinal compositions, and by test, consigner provides prescription and preparation
Process, the experimental results showed that, the refrigeration function for orienting accurate prepared slices of Chinese crude drugs Yinqiao San large dosage group is equivalent to traditional Chinese medicine
The refrigeration function of medicine materical crude slice Yinqiao San addition and subtraction large dosage group, the refrigeration function and traditional Chinese medicine medicine materical crude slice Yinqiao San of three dosage groups
Addition and subtraction middle dose group is similar with the refrigeration function of small dose group.
Conclusion
It is (low dose of 0.35g, middle dosage 0.70g/kg, big that the present invention orients accurate three dosage groups of prepared slices of Chinese crude drugs Yinqiao San
Dosage 1.40g/kg), three dosage groups of traditional Chinese medicine medicine materical crude slice Yinqiao San addition and subtraction (low dose of 7.80g/kg, middle dosage 15.60g,
Large dosage of 31.20g/kg), accurate 22.29 times of medicine materical crude slice Yinqiao San of orientation are all larger than, causes to be solved on rat fever model in yeast
Heat effect is compared.
As the result is shown:
It is caused on rat fever model in yeast:
Fever model control group body temperature after yeast pyrogenicity is apparently higher than 1 DEG C of basal body temperature or more, and (solvent) 1 after medicine
Hour, 2 hours, body temperature maintains 39 DEG C or more after 4 hours, shows that fever model is successful.
Traditional Chinese medicine medicine materical crude slice Yinqiao San addition and subtraction is the recipe of Chinese medicine family Pang Wanmin, has the pungent table that cools completely, clearing heat and detoxicating
The effect of, it is used for anemopyretic cold, fever and headache, dry cough to have sore throat, is classics recipe, this experiment is divided into three agent
Amount group, large dosage have reduction fever rat temperature effect for 1 hour after organizing medicine, have the tendency that within 2 hours, 4 hours reducing rat temperature.
Have the function of within 1 hour after middle dosage medicine reducing rat temperature trend, effect in 2 hours and 4 hours is unobvious after medicine.Small dose group
1 hour after medicine, 2 hours, 4 hours without refrigeration function.
The present invention orients accurate prepared slices of Chinese crude drugs Yinqiao San by 4 taste Chinese medicinal compositions, and by test, consigner provides prescription and preparation
Process, the experimental results showed that, the refrigeration function for orienting accurate prepared slices of Chinese crude drugs Yinqiao San large dosage group is equivalent to traditional Chinese medicine
The refrigeration function of medicine materical crude slice Yinqiao San addition and subtraction large dosage group, the refrigeration function and traditional Chinese medicine medicine materical crude slice Yinqiao San of three dosage groups
Addition and subtraction middle dose group is similar with the refrigeration function of small dose group.
Claims (10)
- It is a sealable container tank 1. a kind of accurate Chinese medicine frequency modulation of orientation stews, intelligent cover is oriented by fangs (1) and frequency modulation (2) it is composed；It is characterized by: the cover (2) is that frequency modulation orients intelligent cover, inside is divided into upper, middle and lower-ranking knot Structure；It are furnished with stainless steel filter screen screen drum (11) in the fangs (1).
- 2. Chinese medicine frequency modulation according to claim 1 stews, it is characterised in that: the middle layer of the cover (2), one side setting Frequency modulation orienting device (4) are arranged in intelligent controlling device (3), the other side；The intelligent controlling device (3) and frequency modulation orienting device (4) intermediate to be equipped with frequency modulation directional material (10), frequency modulation directional material (10) and intelligent controlling device (3) conjugation generate frequency modulation orientation Effect；The lower layer is provided with sensor probe (5) and one or several hole pipes (9) for leading to middle layer；Sensor probe is stretched Enter in fangs (1)；The upper layer is provided with sound broadcasting device (8), shows indicator light (12) and power switch (13).
- 3. Chinese medicine frequency modulation according to claim 2 stews, it is characterised in that: the intelligent controlling device (3) includes integrated Circuit board (6) and battery (7).
- 4. Chinese medicine frequency modulation according to claim 3 stews, it is characterised in that: the sound broadcasting device (8) and battery (7) have Electric wire is connect with vlsi circuitry plate (6)；Live wire connects the signal of sensor probe (5) and vlsi circuitry plate (6) It connects.
- 5. Chinese medicine frequency modulation according to claim 1 stews, it is characterised in that: the fangs (1) is that have heat insulation function not Become rusty steel or ceramics or plastics tank body.
- 6. Chinese medicine frequency modulation according to claim 2 stews, it is characterised in that: the sensor probe (5) is 2-5 centimetres long.
- 7. the Chinese medicine frequency modulation according to claim 2 or 6 stews, it is characterised in that: the sensor probe in the cover (2) (5) it is inserted in stainless steel filter screen screen drum (11).
- 8. Chinese medicine frequency modulation according to claim 2 stews, it is characterised in that: it is stamped waterproof ventilated membrane on the hole pipe (9), Waterproof permeable membrane is the waterproof membrane that aperture is 1nm-1um, and the micropore of the waterproof ventilated membrane is waterproof while can also serve as quantum Effect channel, the Chinese medicine brewing liquid in quantum wave energy and fangs (1) that material and device in cover (2) occurs generate quantum Effect realizes that frequency modulation orients synergistic effect.
- 9. Chinese medicine frequency modulation according to claim 1 stews, it is characterised in that: the frequency modulation directional material (10) is to act on Single compound, composition or the biological products of biological acceptor, i.e., have the pharmacological actives of accurate adjustment effect to biological acceptor Matter；Frequency modulation directional material (10) is also added with light quantum carrier mass, that is, tourmaline powder.
- 10. the application method that a kind of Chinese medicine frequency modulation stews, it is characterised in that: the prepared slices of Chinese crude drugs that orientation is precisely formulated are placed on fangs (1) it in the mesh screen cylinder in, is placed in fangs (1), 300-400 milliliters of water of 90 DEG C or more is poured into fangs (1), cover cover (2), sensor probe (5) gos deep into liquid；Start intelligent control knob, start intelligent control frequency modulation oriented program, sensor is visited Needle (5) inductive signal is in the perceived identification of integrated circuit, by intelligent control voice broadcast, temperature in audio frequency vibration and fangs (1) Degree induction, intense intelligent controlling device (3) the frequency modulation directional material (10) intermediate with frequency modulation orienting device (4), it is total to generate quantum It is in harmony effect, then is in harmony altogether by quantum effect access opening pipe (9) with sensor probe (5), acts on fangs (1) interior low-temperature extraction and determine To accurate prepared slices of Chinese crude drugs soup, conjugation generates quantum effect, orients to the Chinese medicine frequency modulation in fangs (1)；When program is completed, automatically Cover (2) are opened after alarm, pour out soup in fangs.
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Application publication date: 20191029 |