CN110384240A - Hypoglycemic vitamin and probiotics fermention object powder alimentation composition and its application - Google Patents

Hypoglycemic vitamin and probiotics fermention object powder alimentation composition and its application Download PDF

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CN110384240A
CN110384240A CN201910708111.0A CN201910708111A CN110384240A CN 110384240 A CN110384240 A CN 110384240A CN 201910708111 A CN201910708111 A CN 201910708111A CN 110384240 A CN110384240 A CN 110384240A
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vitamin
hypoglycemic
probiotics fermention
alimentation composition
object powder
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顾茂健
苏健梅
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Xuan Tai Bio Tech Ltd Shanghai
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Xuan Tai Bio Tech Ltd Shanghai
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

The invention discloses a kind of hypoglycemic vitamin and probiotics fermention object powder alimentation composition and its application, the component including parts by weight: 10 parts~15 parts of vitamin mixed powder, 1~5 part of probiotics fermention object powder, 0.5 part~70 parts of sugar alcohol.The present invention is safe and healthy, can enter blood by buccal absorption in Orally disintegrating, head cross answer it is small, it is rapid-action, also reduce destruction of the gastric acid to the alimentation composition, improve bioavilability.The composition, which also has, prevents and treats the eye diseases such as dry and astringent weak ophthalmodynia, dark adaptation, eye-blurred, photophobia, eyes, blink, myopia or macular degeneration, also has anti-aging, anti-inflammatory, the effect for improving immunity.

Description

Hypoglycemic vitamin and probiotics fermention object powder alimentation composition and its application
Technical field
The present invention relates to a kind of hypoglycemic alimentation compositions.
Background technique
Diabetes are the universally acknowledged diseases for being difficult to cure, and are by inherent cause, immunologic function disorder, microorganism infection And its various virulence factors of toxin, free radical toxin, mental element etc. act on body and lead to hypoinsulinism, insulin A series of metabolic disorder syndromes such as sugar, protein, fat, water and electrolyte of resistance etc. and initiation, clinically with hyperglycemia For main feature, typical patient may occur in which the performances, i.e. " three-many-one-little " symptom such as diuresis, more drinks, more food, syntexis.
Diabetes can cause multiple complications.If diabetes do not obtain enough control, some urgency can be caused Property complication, as hypoglycemia, ketoacidosis, non-ketone hyperosmolar coma, glucose -lipid metabolism disorder and inhereditary material stability drop It is low.Serious long-term complications include: cardiovascular disease, (also known as diabetic nephropathy is that developing country is non-for chronic renal failure The principal disease of aged adult's blinding), neuropathy and microangiopathies.Wherein, microangiopathies may cause erection function Energy obstacle (impotence) and wound are difficult to heal.And foot is difficult to the wound to heal then and may cause gangrene and (is commonly called as " diabetes Foot "), and then lead to patient's amputation.
Currently, the drug for treating diabetes is various, type has Chinese medicine class, western medicine class, the medicine of these treatment diabetes Object has certain curative effect, but haves the defects that certain: western medicine class has certain side effect, such as melbine, can be quickly after intake Blood glucose is reduced, control is bad to easily lead to hypoglycemia；Chinese medicine class treatment speed is slow, and current Chinese medicine material is mostly artificial kind It plants, unsatisfactory curative effect；The health care products such as good propolis, the royal jelly sold in the market, it is expensive, and contain certain sugar, it is not suitable for Diabetes patient's long-term consumption.The insulin of injection mostly contains hormone, can generate adverse effect to human body." megavitamin D3 supplements influence to diabetes rat glycolipid metabolism and DNA damage " in a text, it is noted that large dosage of vitamin D 3 can drop The value of fasting blood glucose, but do not have significant difference, and large dosage of vitamin D 3 can be to causing Serum Calcium Phosphorus unbalance and rouge The side effects such as matter metabolic disorder；In " influence of the vitamin A bound insulin intervention to STZ blood glucose in diabetic rats " text, mention Blood glucose value can be reduced to replenishing vitamins A, but does not have significant difference.It is got over by the research of the Dietary frequency of target spot of intestinal flora Come more, is also increasingly become research hotspot by the concern of scientists.Such as Chinese Tiny ecosystem magazine 2 months 2018 the 30th Rolled up for the 2nd phase the mechanism of action and phase that probiotics prevention blood glucose is referred in " research achievement of the probiotics in Regulation of blood glucose " text Experimental data is closed, but has been only referred to viable bacteria, is not related to probiotics fermention object but, probiotics is influenced by temperature and oxygen, is used Property is restricted.Probiotics fermention object powder is sterilising prods, is not influenced by temperature and oxygen, and application range is wider, more passes through Ji.
Summary of the invention
The object of the present invention is to provide a kind of hypoglycemic vitamin and probiotics fermention object powder alimentation composition and its answer With to meet the needs of people.And this composition also has intestinal health, raising immune, treats the effect of canker sore.
The hypoglycemic vitamin and probiotics fermention product powder alimentation composition, the component including parts by weight:
10 parts~15 parts of vitamin mixed powder
1~5 part of probiotics fermention object powder
0.5 part~70 parts of sugar alcohol
Preferably, further includes:
59~15 parts of disintegrating agent
0.4~10 part of lubricant
The vitamin mixed powder includes vitamin A, vitamin D, vitamin B5 and vitamin B12, weight ratio are as follows:
Vitamin A: vitamin D: vitamin B5: vitamin B12=1:0.001~0.1:5~25:0.0008~0.01；
Preferably, vitamin A: vitamin D: vitamin B5: vitamin B12=vitamin A: vitamine D3: vitamin B5: Vitamin B12=1:0.01~0.03:10~15:0.003~0.004
The vitamin A includes one or more of retinol acetate and beta carotene, and preferably acetic acid view is yellow The mixture of ester and beta carotene, weight ratio are retinol acetate: beta carotene=1:1~4:1
The vitamin D includes one or more of calciferol and vitamine D3；
The vitamin B5 is calcium pantothenate；
The probiotics fermention object powder be lactobacillus plantarum, Lactobacillus salivarius, bifidobacterium longum, lactobacillus acidophilus hair Ferment product, containing lactic acid, victory peptide, mycelial polysaccharides, hydrogen peroxide, ablastins, biacetyl flavonoids, vitamin and minerals etc., The product of Anhui Jin Qiao company offer is provided；
The sugar alcohol is selected from one of sweet and sour sweet dew, antierythrite, D-sorbite, xylitol or a variety of；
The disintegrating agent be selected from cornstarch, sodium carboxymethyl starch, croscarmellose sodium, crospovidone and One of gas-producing disintegrant is a variety of；
The lubricant is selected from magnesium stearate, fumaric acid odium stearate, macrogol, leucine, sucrose ester, rich horse One of sour sodium is a variety of；
The preparation method of hypoglycemic vitamin and probiotics fermention product powder alimentation composition of the invention is conventional Physical mixing processes after mixing, can be used method well known in the art, be prepared into tablet.
Test proves that hypoglycemic vitamin of the invention and probiotics fermention product powder alimentation composition have blood glucose Significant reduction effect, can be used for preparing health-caring product capable of reducing blood sugar；
The invention further relates to a kind of health-caring product capable of reducing blood sugar, including a effective amount of hypoglycemic vitamin and benefit of health care Raw bacterium fermentation material powder alimentation composition and pharmaceutically acceptable carrier, carrier disintegrating agent as mentioned or lubricant One or more of.
The beneficial effects of the present invention are: the present invention is safe and healthy, the present invention can be inhaled in Orally disintegrating by mucous membrane of mouth Take in into blood, head cross answer it is small, it is rapid-action, also reduce destruction of the gastric acid to the alimentation composition, improve bioavilability. The composition, which also has, prevents and treats dry and astringent weak ophthalmodynia, dark adaptation, eye-blurred, photophobia, eyes, blink, myopia or view The eye diseases such as film macular degeneration also have anti-aging, anti-inflammatory, the effect for improving immunity.
Specific embodiment
Embodiment 1
Formula:
Wherein: the vitamin mixed powder includes vitamin A, vitamin D, vitamin B5 and vitamin B12, weight ratio Are as follows:
Vitamin A: vitamine D3: vitamin B5: vitamin B12=1:0.01:10:0.004；
The vitamin A is the mixture of retinol acetate and beta carotene, weight ratio are as follows:
Retinol acetate: beta carotene=2:1
Production method: it after each component is mixed, adopts with method known in this field, is prepared into tablet.
Control group 1
In vitamin mixed powder, vitamin A: vitamine D3: vitamin B5: vitamin B12=1:0.01:10:0.004, Weight ratio；
Production method: it is adopted after each component is mixed and is prepared into tablet with method known in this field.
Control group 2
Production method: it is adopted after each component is mixed and is prepared into tablet with method known in this field.
Embodiment 2
Vitamin A: vitamine D3: vitamin B5: vitamin B12=1:0.03:15:0.003, weight ratio；Sugar alcohol: sweet dew Sugar alcohol: D-sorbite=9:1, weight ratio；
Vitamin A in mixed powder is the mixture of retinol acetate and beta carotene, retinol acetate: β-carrot Element=3:1
Production method: it adopts with method known in this field, is prepared into tablet；
Control group 3
Vitamin A: vitamine D3: vitamin B5: vitamin B12=1:0.03:15:0.003
Sugar alcohol: mannitol: D-sorbite=9:1, weight ratio；
It adopts and is prepared into tablet with method known in this field.
Control group 4
Sugar alcohol: mannitol: D-sorbite=9:1, weight ratio；
It adopts and is prepared into tablet with method known in this field.
Embodiment 3
1. zoopery
(1) animal selects: selecting ICR mouse (offer of zoopery middle school, Shenyang Pharmaceutical University), between weight 18-22g.
(2) drug administration: being all made of gastric infusion, and dosage is expressed as dosage 100mg/kg weight~200mg/kg weight
(3) the drop blood of this composition hyperglycemia model and grouping: is studied using alloxan cause experimental hyperglycemia model Sugar effect.
After ICR mouse fasting 12h, according to dosage alloxan is injected intraperitoneally in 180mg/kg, and mouse tail end takes hematometry after 5d Blood glucose.Blood glucose value is chosen in the mouse of 11.1~24mmol/L, is grouped at random, every group 12, totally 8 groups, blood glucose value between each group Mean value is not statistically significant (P > 0.05).
Be respectively model control group, example 1 group, 2 groups of embodiment, control 1 group, control 2 groups, control 3 groups, control 4 groups, Melbine group；Embodiment group and the daily stomach-filling 150mg/kg of each control group.The daily stomach-filling melbine of melbine group 250mg/kg.Taking 12 mouse that alloxan is not injected intraperitoneally is Normal group；
0.5% sodium carboxymethylcellulose of Normal group and the daily stomach-filling of model control group in equal volume, embodiment group, The product of corresponding dosage is given in stomach-filling respectively for control group and melbine group, 10mL/kg, 1 time a day continuous gavage 8 weeks.
(4) index determining: measuring every group of every daily inleting appetite of animal in experimentation, calculate every group of every mouse be averaged day into Appetite (difference of adjacent two days every group of animal feeds/every group of number of animals, altogether record 8 weeks it is for statistical analysis)；Mouse fasting is not After prohibiting 6~8h of water, cuts tail point and blood blood glucose meter is taken to measure fasting blood-glucose.At administration 8 week, mouse weight is weighed, eyeball is plucked and takes blood, After the static 1h of room temperature, it is centrifugated serum, Elisa kit method measures serum insulin level.
(5) data are analyzed: each group of data is indicated with mean+SD (x ± s), carries out single factor test using SPSS software Variance analysis is compared between multiple groups two-by-two using LSD method, is that difference has conspicuousness with P < 0.05.
(5) experimental result
1 embodiment of table is averaged to mouse and day uses up appetite and changes of weight
Group Quantity Average daily inleting appetite (g) Weight (g) after 8 weeks
Normal group 12 3.24±0.60 26.81±2.29
Model control group 12 4.44±0.78** 56.78±3.40**
Example 1 group 12 4.57±0.72** 63.32±3.36**#
Compare 1 group 12 4.37±0.80** 56.67±1.96**
Compare 2 groups 12 4.45±1.01** 55.98±2.87**
2 groups of embodiment 12 4.50±0.73** 65.28±3.94**#
Compare 3 groups 12 4.46±0.82** 53.90±2.48**
Compare 4 groups 12 4.47±0.74** 55.57±2.90**
Melbine group 12 4.35±0.92** 62.26±4.70**#
Note: compared with Normal group, * * P < 0.01；Compared with model group, #P < 0.05；
2 embodiment of table takes the influence to mouse fasting blood-glucose in 8 weeks
Note: compared with Normal group, * P < 0.05, * * P < 0.01；Compared with model group, #P < 0.05, ##P < 0.01；
Influence of 3 embodiment of table to mice serum insulin level
Group Quantity Serum insulin (ng/mL)
Normal group 12 0.90±1.20
Model control group 12 54.21±39.51**
Example 1 group 12 57.04±28.58**
Compare 1 group 12 84.29±29.47**#
Compare 2 groups 12 87.78±37.43**#
2 groups of embodiment 12 57.67±28.90**
Compare 3 groups 12 89.33±29.05**#
Compare 4 groups 12 88.65±37.81**#
Melbine group 12 66.54±59.00**
Note: compared with Normal group, * * P < 0.01；Compared with model group, #P < 0.05；
Know from table 1, table 2, table 3, embodiment 1 and 2 effect of embodiment are close with melbine group, are better than each control group；
Clinical observation；
1. Lee, female, 69 years old, three is high for many years, and blood glucose is unstable always, by taking embodiment 1 45 days, glucostasis, Frequent micturition, glucose in urine, thirsty symptom obviously disappear, and body is obviously comfortable.Former AC Sugar is 13mmol/L or so, and blood glucose is steady after meal Determine 18.0mmol/L or so, existing AC Sugar stablizes 8mmol/L or so, after meal glucostasis 11mmol/L or so.It takes 60 days AC Sugar stablizes 7.5mmol/L or so afterwards, after meal glucostasis 10.5mmol/L or so.In the process, patient feeds back immunity It gets a promotion.
2. Mr. Wang, male, 65 years old, many years diabetes, by taking embodiment 2 45 days, glucostasis, three-many-one-little symptom It is basic to disappear.Former AC Sugar is 12.5mmol/L or so, after meal glucostasis 17.0mmol/L or so, and existing AC Sugar is stablized 7.0mmol/L or so, after meal glucostasis 9.5mmol/L or so；After taking 60 days, AC Sugar stablizes 6.5mmol/L or so, Glucostasis 9.0mmol/L or so after meal.In the process, patient's physical strength is promoted, and is moved not easy to fatigue.

Claims (10)

1. hypoglycemic vitamin and probiotics fermention object powder alimentation composition, which is characterized in that the component including parts by weight:
10 parts~15 parts of vitamin mixed powder
1~5 part of probiotics fermention object powder
0.5 part~70 parts of sugar alcohol.
2. hypoglycemic vitamin according to claim 1 and probiotics fermention object powder alimentation composition, which is characterized in that Further include:
59~15 parts of disintegrating agent
0.4~10 part of lubricant.
3. hypoglycemic vitamin according to claim 1 and probiotics fermention object powder alimentation composition, which is characterized in that The vitamin mixed powder includes vitamin A, vitamin D, vitamin B5 and vitamin B12, weight ratio are as follows:
Vitamin A: vitamin D: vitamin B5: vitamin B12=1:0.001~0.1:5~25:0.0008~0.01.
4. hypoglycemic vitamin according to claim 1 and probiotics fermention object powder alimentation composition, which is characterized in that Vitamin A: vitamin D: vitamin B5: vitamin B12=vitamin A: vitamine D3: vitamin B5: vitamin B12=1: 0.01~0.03:10~15:0.003~0.004.
5. hypoglycemic vitamin according to any one of claims 1 to 4 and probiotics fermention object powder alimentation composition, It is characterized in that, the vitamin A includes one or more of retinol acetate and beta carotene.
6. hypoglycemic vitamin according to claim 5 and probiotics fermention object powder alimentation composition, which is characterized in that The vitamin A is the mixture of retinol acetate and beta carotene, and weight ratio is retinol acetate: beta carotene= 1:1~4:1.
7. hypoglycemic vitamin according to any one of claims 1 to 4 and probiotics fermention object powder alimentation composition, It is characterized in that, the vitamin D includes one or more of calciferol and vitamine D3.
8. hypoglycemic vitamin according to any one of claims 1 to 4 and probiotics fermention object powder alimentation composition, It is characterized in that, the vitamin B5 is calcium pantothenate.
9. described in any item hypoglycemic vitamins and probiotics fermention object powder alimentation composition exist according to claim 1~8 Prepare the application in health-caring product capable of reducing blood sugar.
10. a kind of health-caring product capable of reducing blood sugar, raw including a effective amount of hypoglycemic dimension according to any one of claims 1 to 8 of health care Element and probiotics fermention object powder alimentation composition and pharmaceutically acceptable carrier.
CN201910708111.0A 2019-08-01 2019-08-01 Hypoglycemic vitamin and probiotics fermention object powder alimentation composition and its application Pending CN110384240A (en)

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CN111150059A (en) * 2020-01-19 2020-05-15 西倍健生物科技(深圳)有限公司 Special probiotic bacterium composition for women and application thereof
CN114376135A (en) * 2020-10-16 2022-04-22 杭州创盈生物科技有限公司 Intestine-moistening bowel-relaxing probiotic composition solid beverage and preparation method thereof

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US20180125901A1 (en) * 2016-11-03 2018-05-10 Cell Biotech Co., Ltd. Composition for preventing or treating bone disease, obesity and lipid-related metabolic disease
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CN111150059A (en) * 2020-01-19 2020-05-15 西倍健生物科技(深圳)有限公司 Special probiotic bacterium composition for women and application thereof
CN114376135A (en) * 2020-10-16 2022-04-22 杭州创盈生物科技有限公司 Intestine-moistening bowel-relaxing probiotic composition solid beverage and preparation method thereof

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