CN1103776A - Tooth-paste with hypertension and brain-thrombus-proof medicine - Google Patents
Tooth-paste with hypertension and brain-thrombus-proof medicine Download PDFInfo
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- CN1103776A CN1103776A CN 93120104 CN93120104A CN1103776A CN 1103776 A CN1103776 A CN 1103776A CN 93120104 CN93120104 CN 93120104 CN 93120104 A CN93120104 A CN 93120104A CN 1103776 A CN1103776 A CN 1103776A
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Abstract
On the basis of every component of available common tooth paste the medicine for preventing and curing hypertension is added in and relying on the tooth paste as the carrier of hypotensor, the micro amount of hypotensor contained in tooth paste is dissolved in the saliva and quickly permeated, dispersed and adsorbed through buccal mucous, sublingual capillary net and channels and collaterals acupoints. It enters the circulation of humanbody to achieve the goal for preventing and curing hypertension. Through the clinical trial and observation, the curative effect is same as the oral level but said invention features easy, safety, quick and stable.
Description
The invention belongs to the health medicine toothpaste type, mainly propose a kind of tooth-paste with hypertension and brain-thrombus-proof medicine.
Present existing toothpaste, only be confined to the oral health care aspect, still needleless is to a certain class disease, reach the medicated toothpaste of whole body control by brushing teeth, hypertension is one of commonly encountered diseases, frequently-occurring disease of serious harm people's health, at present this is not still had the radical cure method, only reliable enalapril meleate thing is kept normal arterial pressure, and long-term prescription not only increases the weight of blood pressure patient's psychological burden, forgets easily in addition and causes hypertension rebound, brings out the heart, cerebrovascular accident.
Purpose of the present invention promptly is this, promptly seek the ideal medicament carrier of a kind of science, safety, popularity, persistency, habituation, simplicity, best dosing mode and optimum dosing way, the hypertension prevention treatment is combined with oral health care, thus the large tracts of land colony preventing and controlling of promotion hypertension.
The present invention relies on toothpaste for falling prevention and cure of schistosomiasis bolt pharmaceutical carrier according to modern medical theory and Chinese medicine meridians and picture of the tongue theory, adds prevention, medicine through screening, makes when carrying out oral health care, can carry out prevention, the treatment of hypertension; The present invention takes multifrequency inferior by popular hygienic habit-teeth brushing way, and long brush is at interval gargled means, micro-antihypertensive drugs in the toothpaste is dissolved in the saliva through port transmucosal, Sublingual capillary network and meridian point channel rapid permeability, diffusion, absorption; Avoid gastrointestinal tract and liver first-pass effect destruction, directly enter the body circulation, reach quick blood pressure lowering medicine, continual and steady, blood viscosity lowering, the purpose of microcirculation improvement.
Another task of the present invention is the pharmaceutical formulation that proposes medicated toothpaste, and the component of its medicine has: clonidine hydrochloride, nifedipine, ligustrazine phosphate, tetrandrine, angelicin.
Its drug component is outstanding based on Chinese medicine, the bonded principles of formulating prescriptions of Chinese medicine and western medicine.
Wherein clonidine hydrochloride is scratched the functionality Altace Ramipril in being; Nifedipine is the anti-agent antihypertensive drugs of calcium, and the coronary artery expansion medicine that produces effects cooperates with clonidine hydrochloride, increases antihypertensive effect, and coronary blood flow increasing reduces myocardial oxygen consumption simultaneously, prevents and treats the infringement of hypertension to heart; Ligustrazine phosphate is the bleed of invigorating blood circulation, and anti-platelet aggregation, the effect of expansion small artery are arranged, and is used to prevent and treat obliterated cerebral vascular diseases such as cerebral thrombosis, cerebral embolism; Tetrandrine; Inducing diuresis to remove edema, analgesia, blood pressure lowering are used for neuralgia and vascular hypertension; Angelicin; Enrich blood and invigorate blood circulation, prevent and treat arrhythmia, cerebral thrombosis, blood pressure lowering and do not influence the rhythm of the heart, antiplatelet aggregation.
The above compatibility of drugs of the present invention, effectively microcirculation improvement improves the hemorheology state, lowering and stabilizing blood pressure, prevention thrombosis, angelicin, ligustrazine phosphate can also be avoided the effect of paying of clonidine hydrochloride.
In the oral cavity and tongue surface mucosa is formed by stratified squamous epithelium cell and lamina propria, include abundant lymphatic vessel blood vessel, the intensive one-tenth net of Sublingual blood capillary, and capillary wall is made up of monolayer endothelial cell, this organization is loose, has the duct, gap, water-soluble substances can directly penetrate in the blood vessel along the duct, enter body circulation, the traditional Chinese medical science twelve regular channels and eight extra-channel all with oral cavity and tongue through the cave commissure mutually, medicine can absorb human body along channel system, screening is based on the anti-prescription of suppository of the blood pressure lowering of Chinese medicine, daily hygiene custom by brushing teeth is absorbed medicine rapidly by human body when brushing teeth, reach health care, the double effects of preventing and curing diseases.And be difficult for forgeing, do not have psychological mental burden.
Because medicine directly enters blood circulation, do not destroyed, so dose reduces relatively by Digestive system and liver, avoided the effect of paying of taking medicine for a long time.
Observe by 198 routine clinical experiments, curative effect reaches the level identical with the oral blood pressure lowering medicine, and has advantages such as easy, safe, quick-acting, stable.
Medicine of the present invention is made tooth-paste with hypertension and brain-thrombus-proof medicine of the present invention applicable to various toothpaste matrixes.
The drug dilution that the present invention is selected, clean after, add toothpaste basis and adopt existing toothpaste preparation technology, make medicated toothpaste of the present invention.
Prove through its efficacy result of clinical experiment:
1, the design concept of the anti-bolt medicated toothpaste dosing mode of blood pressure lowering, dosing way and pharmaceutical carrier, prescription formation has science, novelty, quick-acting, practicality.
2, antihypertensive effect (P＜0.01), prove this toothpaste brush teeth to hyperpietic's efficacy of antihypertensive treatment significantly, effect rapidly.
3, control experiment (P＞0.05) confirms that brush teeth hypotensive effect and the effect of conventional tablet oral blood pressure lowering of this toothpaste has comparability, reliability, feasibility.Still unique simplification, safety, quick-acting, habituation, stability, popularity.
Embodiment:
Anti-bolt drug screening of blood pressure lowering and content:
The every gram toothpaste of clonidine hydrochloride 0.075mg/ content
The every gram toothpaste of pyridine nitrate 10mg/ content
The every gram toothpaste of ligustrazine phosphate 50mg/ content
The every gram toothpaste of tetrandrine 20mg/ content
The every gram toothpaste of angelicin 50-60mg/ content
Toothpaste matrix screening: as the transparent toothpaste prescription
The silicon dioxide sodium lauryl sulphate
Sorbitol spice
The SE sweeting agent
The sodium alginate pigment
Magnetized, mineralized water
Preparation technology's flow process of the present invention:
Glue → glue ageing (antihypertensive drugs dissolves in)/() mastic kneading → mastic storage → grinding → vacuum outgas → fill → packing → finished product
The ingredient that the present invention chooses, the pure medicine (Powdered or injection) that all adopts regular pharmaceutical factory to produce goes out various drug doses by the total that feeds intake, and is that scattered paste shape is standby with medicine with the magnetic water dilution, with magnetic water medicine is cleaned at last and is poured into reactor.
Preparation technology of the present invention all adopts existing toothpaste production technology.
As " mastic kneading " in the technological process is various raw materials to be put into stainless steel cauldron in proportion fully stir, and " storage " is to stop to stir the back to place, and the interior portion gas of mastic is overflowed automatically; " grinding " is that mastic is ground one time by the molecule barreling; " vacuum outgas " is that the mastic after grinding is purified the intravital bubble of cream by vacuum pump; Mastic can be squeezed into the filling machine fill afterwards.
Above-mentioned mastic comprises medicine.
Claims (3)
1, a kind of tooth-paste with hypertension and brain-thrombus-proof medicine, contain the various compositions of existing ordinary toothpaste, feature of the present invention is to add to prevent, treat hypertensive medicine, relying on toothpaste is the carrier of the anti-bolt medicine of blood pressure lowering, micro-antihypertensive drugs in the toothpaste is dissolved in the saliva through port transmucosal, Sublingual capillary network and meridian point channel rapid permeability, diffusion, absorption, directly enter the body circulation, reach the purpose of prevention, treatment hypertension.
2, according to the described tooth-paste with hypertension and brain-thrombus-proof medicine of claim 1, it is characterized in that: the drug component of selection is: clonidine hydrochloride, nifedipine, ligustrazine phosphate, tetrandrine, angelicin.
3, according to claim 1 or 2 described tooth-paste with hypertension and brain-thrombus-proof medicine, it is characterized in that: the existing toothpaste component of adding carries out PROCESS FOR TREATMENT such as mastic kneading, storage, grinding, vacuum outgas with the magnetic water dilution and after cleaning for Powdered, the liquid drug that will choose, fill, packing becomes finished product of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93120104 CN1103776A (en) | 1993-12-17 | 1993-12-17 | Tooth-paste with hypertension and brain-thrombus-proof medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93120104 CN1103776A (en) | 1993-12-17 | 1993-12-17 | Tooth-paste with hypertension and brain-thrombus-proof medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1103776A true CN1103776A (en) | 1995-06-21 |
Family
ID=4993165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93120104 Pending CN1103776A (en) | 1993-12-17 | 1993-12-17 | Tooth-paste with hypertension and brain-thrombus-proof medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1103776A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6846478B1 (en) | 1998-02-27 | 2005-01-25 | The Procter & Gamble Company | Promoting whole body health |
| US8277782B2 (en) | 2000-06-30 | 2012-10-02 | The Procter & Gamble Company | Topical oral care compositions comprising host response modulating agents |
-
1993
- 1993-12-17 CN CN 93120104 patent/CN1103776A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6846478B1 (en) | 1998-02-27 | 2005-01-25 | The Procter & Gamble Company | Promoting whole body health |
| US8277782B2 (en) | 2000-06-30 | 2012-10-02 | The Procter & Gamble Company | Topical oral care compositions comprising host response modulating agents |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Address after: No. 6, Changan Road, Jianxi District, Luoyang Applicant after: Zhang Huicheng Inventor after: Zhang Huicheng Applicant before: Wang Dianan Inventor before: Wang Dianan |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: WANG DIANAN TO: ZHANG HUICHENG |
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| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |