CN110368585A - A kind of therapeutic equipment - Google Patents
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- CN110368585A CN110368585A CN201910749396.2A CN201910749396A CN110368585A CN 110368585 A CN110368585 A CN 110368585A CN 201910749396 A CN201910749396 A CN 201910749396A CN 110368585 A CN110368585 A CN 110368585A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36034—Control systems specified by the stimulation parameters
Abstract
The invention discloses a kind of therapeutic equipments, including primary processor, display module, key module, power module, usb interface module, current output interface module, memory, electro photoluminescence detection module, surface electrode and current feedback circuit；The output end of electro photoluminescence detection module and the output end of current feedback circuit pass through current output interface module respectively and connect with surface electrode, and the sawtooth current signal transduction that the alternating polarity that the surface electrode exports current feedback circuit changes to underlying nerve carries out electro photoluminescence.Therapeutic equipment of the invention can prevent and treat a variety of diseases such as hypertension, obesity, diabetes, caput femoris necrosis, gout, and circuit structure is simple, at low cost.
Description
Technical field
The present invention relates to technical field of medical equipment, and in particular to a kind of therapeutic equipment.
Background technique
The most onset of essential hypertension is slow, lacks special clinical manifestation.Common sympton has dizzy, headache, neck
Plate tight, fatigue, palpitaition etc., also may occur in which the heavier symptom such as eye-blurred, nosebleed.It also will appear afflicted organ's correlation disease simultaneously
Shape is for example uncomfortable in chest, shortness of breath, angina pectoris etc..Hypertension can be involved multiple organs and tissue, often involve heart and blood vessel, long-term hypertension
It can cause left ventricular hypertrophy and expansion, petty action astillen/chamber ratio increases, and the diminution of official jargon internal diameter causes important target organ tissue to lack
Blood.Hypertension is because its pathogenic factors is complicated, the course of disease duration is long, and histo pathological change degree is in gradual, side effect and resistance to
Pharmacological property can also increase as treatment time increases.
Obesity is that the accumulation of body fat caused by the multifactor interaction such as heredity, environment is excessive and (or) distribution is different
Often, the chronic metabolic disease of weight gain.Obesity is a kind of different substantiality disease, fat accumulation be due to intake energy with
Balance between human consumption energy gets muddled, and obesity have family accumulation tendency, while study discovery single gene mutation,
Factors such as " thrifty genes " can also cause human obesity.Obesity can be divided into simple obesity and Secondary Obesity two major classes.It is fat
Treatment need to combine a variety of therapeutic modalities while reducing caloric intake, increase the consumption of heat.At present clinic emphasize with
Behavior, diet, the complex treatment based on movement are aided with drug or operative treatment (when meeting drug/operative treatment sign when necessary
When), while Secondary Obesity carries out fat control while treating primary disease.Urgent need while carrying out complex treatment
It is a kind of safely and effectively to quantify the therapeutic modality having no toxic side effect progress after treatment.
Diabetes are one group and knit multiple organs dysfunction especially eye, kidney, heart, blood vessel, nerve with hyperglycemia, multiple groups
The metabolic disease that chronic lesion is characterized.The morbidity of diabetes has genetic heterogeneity with apparent heredity again simultaneously.
It is polygenes and the coefficient complexity of a variety of environmental factors that (including I type and type II diabetes) is most of in diabetic
Disease is only partially because caused by gene mutation.Wherein Type I diabetes is mainly due to the chemistry in environment, virus
IV type hypersensitivity (beta Cell of islet autoimmune disease) caused by equal substances and gene collective effect.Type II diabetes
Mainly increase with defect of insulin secretion, glycogen output, peripheral insulin resistance, polygenic mutation etc. it is related.Control blood glucose and
Improving insulin function in body is the key factor for reducing diabetes and its complication.
Caput femoris necrosis, that is, avascular necrosis of femoral head, also referred to as aseptic necrosis of femoral head.It is due to blood supply of the femoral head
It interrupts or impaired, causes osteocyte, marrow stromal cell and fat cell necrosis that femur header structure is then caused to change, femoral head
It collapses, the disease of joint function disturbance.The reason of causing caput femoris necrosis can be divided into traumatic and atraumatic two major classes, wound
Property avascular necrosis of femoral head be because wound cause femoral head blood transport interrupt and caused by as a result, include fracture of neck of femur,
The dislocation of hip joint and intertrochanteric fracture etc..The specific pathogenesis of avascular necrosis of femoral head is not still very clear,
But a large number of studies show that itself and application, long-term excessive consumption of alcohol, the gene mutation of glucocorticoid etc. are related.
Gout is monosodium urate mineralization in Bones and joints, kidney and positions, caused Acute and chronic inflammation and the group such as subcutaneous
Knit damage, with purine metabolic disturbance and (or) hyperuricemia caused by underexcretion is directly related, belong to metabolic wind
The scope of diseases caused by dampness.Clinically 5%~15% Patients with Hyperuricemia development be gout, show as urarthritis, gout kidney,
Tophus etc..Its specific pathogenic factor is still inaccurate, but the reasons such as gout and living habit, dietary structure are related, Chang Shou
It is cold, tired, drink, the high purine diet of high protein, wound, operation, the reasons such as infection induce lower morbidity.So far, it there is no knot
Structure is simple, it is residential use, prevent antipodagric equipment.
Summary of the invention
It is an object of the present invention to provide a kind of structures simple, residential use, prevention and treatment hypertension, obesity, diabetes, stock
The equipment of a variety of diseases such as head necrosis, gout, the therapeutic equipment can generate a kind of variation of alternating polarity and amplitude by index
It is incremented to the sawtooth current signal of exponential decrease variation, bionical object electrical stimulation current is exported by surface electrode and is passed to corresponding
Underlying nerve.
In order to solve the above technical problems, the embodiment of the present invention provides a kind of therapeutic equipment, comprising: primary processor, display mould
Block, key module, power module, usb interface module, current output interface module, memory, electro photoluminescence detection module, surface
Electrode and current feedback circuit；The display module, the key module, the power module, the usb interface module, institute
State the input terminal of memory, the input terminal of the electro photoluminescence detection module and the current feedback circuit respectively with the main process task
It is defeated that device connection, the output end of the electro photoluminescence detection module and the output end of the current feedback circuit pass through the electric current respectively
Outgoing interface module is connect with the surface electrode, what the alternating polarity that the surface electrode exports the current feedback circuit changed
Sawtooth current signal transduction to underlying nerve carries out electro photoluminescence.
Further, the current feedback circuit includes: signal generating circuit, electric current output control circuit；The signal hair
The output end of raw circuit is connect with the input terminal of the electric current output control circuit, the output end of the electric current output control circuit
For being connect with load resistance；
The signal generating circuit, the sawtooth wave changed for periodically exporting an amplitude by exponential increasing to exponential decrease
Voltage signal；
The electric current output control circuit alternately changes for the sawtooth voltage signal to be converted to polar cycle
Sawtooth current signal.
Preferably, the signal generating circuit includes: first microprocessor and the first analog-digital converter；First micro- place
Reason device signal end connect with the input terminal of first analog-digital converter, the output end of first analog-digital converter with it is described
The output end of signal generating circuit connects.
Preferably, the electric current output control circuit include: the first polarity control circuit, the first current source, high voltage power supply,
Filter circuit；The power control terminal of the first microprocessor is connect with the input terminal of the high voltage power supply, the high voltage power supply
Output end connect with the high-voltage electricity source of first current source；The polarity control terminal of first micro process and described first
The control terminal of polarity control circuit connects, the feedback end of the power end of first polarity control circuit and first current source
Connection；The output end of first analog-digital converter is connect with the input terminal of the filter circuit, the output of the filter circuit
End is connect with the input terminal of first polarity control circuit, the first output end of first polarity control circuit and described the
The first input end of one current source connects, and the of the second output terminal of first polarity control circuit and first current source
First output end of the connection of two input terminals, first current source is connect by positive electrode with the load resistance, and described first
The second output terminal of current source is connect by negative electrode with the load resistance.
Preferably, first polarity control circuit includes: signal amplifier, transistor and analog switch；The letter
The normal phase input end of number amplifier is connect with the input terminal of first polarity control circuit, and the reverse phase of the signal amplifier is defeated
Enter end, the enable end of the analog switch is connect with the source electrode of the transistor, the grid of the transistor and first pole
Property control circuit control terminal connection, the drain electrode of the transistor connect with the feedback end of first current source, the signal
The output end of amplifier is connect with the input terminal of the analog switch, the control terminal of the analog switch and first micro process
The switch control terminal of device connects, the first output end of the first output end of the analog switch and first polarity control circuit
Connection, the second output terminal of the analog switch are connect with the second output terminal of first polarity control circuit.
Preferably, the current feedback circuit further includes the first detection circuit and the second detection circuit, the first detection electricity
Road, second detection circuit first input end connect with the first output end of first current source, it is described first inspection
Slowdown monitoring circuit, second detection circuit the second input terminal connect with the second output terminal of first current source；Described
First output end of one detection circuit is connect by the positive electrode with the load resistance, and the second of first detection circuit
Output end is connect by the negative electrode with the load resistance, the detection output of first detection circuit and described first
First test side of microprocessor connects；Second detection of the output end and the first microprocessor of second detection circuit
End connection.
Preferably, the signal generating circuit includes the second microprocessor and the first digital analog converter；Second micro- place
Reason device signal end connect with the input terminal of first digital analog converter, the output end of first digital analog converter with it is described
The output end of signal generating circuit connects.
Preferably, the electric current output control circuit includes: the second polarity control circuit, the second current source, channel control
Circuit and high-voltage inverter circuit；The input terminal of the input terminal of second current source and the electric current output control circuit connects
It connecing, the output end of second current source is connect with the input terminal of the high-voltage inverter circuit, and the of the high-voltage inverter circuit
One output end is connect with the first input end of second polarity control circuit, the second output terminal of the high-voltage inverter circuit with
Second input terminal of second polarity control circuit connects；Two control terminals of second polarity control circuit respectively with institute
State two polarity control terminals connection of the second microprocessor, the first output end of second polarity control circuit and the channel
The first input end of control circuit connects, second output terminal and the channel control circuit of second polarity control circuit
The connection of second input terminal；First output end of the channel control circuit is connect by positive electrode with the load resistance, described
The second output terminal of channel control circuit is connect by negative electrode with the load resistance.
Preferably, the high-voltage inverter circuit includes transformer, inverter circuit, filter capacitor and rectifier；The change
The input tap of depressor is connect with the output end of second current source；Two input terminals of the inverter circuit respectively with it is described
Two inversion control ends of the second microprocessor connect, and the first of the first output end of the inverter circuit and the transformer is defeated
Enter end connection, the second output terminal of the inverter circuit is connect with the first input end of the transformer；The of the transformer
One output end is connect with the first input end of the rectifier, and the second of the second output terminal of the transformer and the rectifier
Input terminal connection；First output end of the rectifier is connect with the first output end of second polarity control circuit, described
The second output terminal of rectifier is connect with the second output terminal of second polarity control circuit；First pole of the filter capacitor
It is connect with the first output end of second polarity control circuit, the of the output tap of the transformer, the filter capacitor
Two poles are connect with the second output terminal of second polarity control circuit.
Preferably, the current feedback circuit further includes third detection circuit, and the third detection circuit includes isolation amplification
Device, amplifying circuit, the second analog-digital converter and the 4th resistance, the first end of the 4th resistance, the isolated amplifier
Normal phase input end is connect with the output end of the 4th photoelectrical coupler, and amplification is isolated with described in the second end of the 4th resistance
The inverting input terminal of device connects；The isolated amplifier positive output end is connect with the normal phase input end of the amplifying circuit, institute
Isolated amplifier reversed-phase output is stated to connect with the inverting input terminal of the amplifying circuit；The output end of the amplifying circuit and institute
State the input terminal connection of the second analog-digital converter, the inspection of the output end of second analog-digital converter and second microprocessor
Survey end connection.
Further, the output current parameters of the current feedback circuit are as follows: frequency 1-6Hz, pulsewidth 1-6ms, delay
Time 0-120s, rise time 0-10s, plateau time 0-30s, fall time 0-10s, time of having a rest 0-30s.
Compared with the prior art, therapeutic equipment of the invention generates a kind of alternating polarity change by the current feedback circuit
The sawtooth current signal that change and amplitude are changed by exponential increasing to exponential decrease, passes through the surface being placed at body corresponding portion
Electrode exports bionical physics electro photoluminescence and swashs, so as to improve hypertension, obesity, diabetes, caput femoris necrosis, gout related symptoms,
The therapeutic equipment structure is simple, is suitble to residential use.
In fact, medical worker can choose other positions for being suitble to low-frequency electrostimulating, it might even be possible to adjust electro photoluminescence
Parameter can also take different parameter and the course for the treatment of according to the tolerance of different patients.These different parameters, the course for the treatment of, service portion
Position, on the basis of not departing from the principle of the present invention, belongs to protection scope of the present invention.
Detailed description of the invention
Fig. 1 is a kind of functional block diagram of the invention；
Fig. 2 is a kind of functional block diagram of current feedback circuit provided by the embodiment of the present invention one；
Fig. 3 is a kind of functional block diagram of current feedback circuit provided by the embodiment of the present invention two；
Fig. 4 is the circuit diagram of current feedback circuit described in Fig. 3；
Fig. 5 is a kind of functional block diagram of current feedback circuit provided by the embodiment of the present invention three；
Fig. 6 is the circuit diagram of current feedback circuit described in Fig. 5；
Fig. 7 is the circuit diagram of channel control circuit in Fig. 5；
Fig. 8 is the circuit diagram of third detection circuit in Fig. 5；
Fig. 9 is the schematic diagram of sawtooth current signal provided by the embodiment of the present invention；
Figure 10 is the schematic diagram of multiple groups sawtooth current signal provided by the embodiment of the present invention；
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Embodiment one
Please refer to Fig. 1, Fig. 2, the functional block diagram of therapeutic equipment provided by the embodiment of the present invention one, comprising: main process task
Device 100, display module 101, key module 102, power module 103, usb interface module 104, current output interface module 105,
Memory 106, electro photoluminescence detection module 107, surface electrode 108 and current feedback circuit 109；It is the display module 101, described
Key module 102, the power module 103, the usb interface module 104, the memory 106, the electro photoluminescence detect mould
The input terminal of the input terminal of block 107 and the current feedback circuit 109 is connect with the primary processor 100 respectively, the electricity thorn
The output end of the output end and the current feedback circuit 108 that swash detection module 107 passes through the current output interface mould respectively
Block 105 is connect with the surface electrode 108, and the alternating polarity that the surface electrode 108 exports the current feedback circuit 109 becomes
The sawtooth current signal transduction of change to underlying nerve carries out electro photoluminescence.
Wherein, the sail type wave signal of the two-phase of the exportable different parameters of the current feedback circuit 109.
Such as: the current parameters range are as follows:
Frequency is 1~6Hz, and pulsewidth is 1~6ms, and delay time 0-120s, the rise time is 0~10s, plateau time 0
~30s, fall time are 0~10s, and time of having a rest 0-30s, current waveform is two-phase multiple groups sail type wave.
Wherein, the current feedback circuit 109 controls in assigned work duration, such as in 1~60 minute described in output
The sail type wave signal of two-phase.
The surface electrode 108, including connect one to one with the current output interface module 105 connecting pin, nothing
Woven fabric, conductive gel layer, conductive fiber layer.Wherein, the conductive fiber layer is conductive fiber or conductive film.The surface electricity
108 shape of pole can be (30~300) mm × (30~300) mm for round, square and rectangle, size range.Preferably, institute
The shape of surface electrode 108 is stated as circle, size is specially 50mm × 50mm
The current output interface module 105 is connected with the connecting pin of the surface electrode 108, with to the surface electrode
The sail type wave signal of the 108 corresponding two-phases of output, i.e., bionical object electrical stimulation current.
The electro photoluminescence detection module 107, can monitor the surface electrode 108 and the current output interface module 105,
The connection status of human body, if detecting, connecting path is disconnected, and will turn off electric current output.
The sail type wave signal of the two-phase for the positive and negative periodic symmetry that the current feedback circuit 109 generates passes through surface electrode 108
It is transmitted to subcutis, by the way that surface electrode 108 is bonded the corresponding part of human body, reaches therapeutic effect.Surface electrode
Use see the table below:
Wherein, current feedback circuit 109 provided in an embodiment of the present invention, comprising: signal generating circuit 1, electric current output control
Circuit 2；The output end of the signal generating circuit 1 is connect with the input terminal of the electric current output control circuit 2, and the electric current is defeated
The output end of control circuit 2 with load resistance for connecting out；
The signal generating circuit 1, the sawtooth changed for periodically exporting an amplitude by exponential increasing to exponential decrease
Wave voltage signal；
The electric current output control circuit 2 alternately becomes for the sawtooth voltage signal to be converted to polar cycle
The sawtooth current signal of change.
As shown in figure 9, the sawtooth current signal is sail type wave signal, it can specifically pass through the type wave function formula that such as lowers the sail
It indicates:
Wherein t is the time, and y is the amplitude of t moment, and a is amplitude peak, and b is curve initial tangent slope, and 0~T1 is upper
Section is risen, T1~T2 is decaying section, waveform shape can be changed by changing parameter b.
Enable T1=T2=5b=T
As shown in Figure 10, sawtooth current signal is positive the symmetrical two-phase sail type wave of negative cycle, the current feedback circuit 109
By generating a kind of polar cycle sawtooth current signal that alternately variation and amplitude are changed by exponential increasing to exponential decrease,
Circuit structure is simple, at low cost.
Embodiment two
Fig. 3, Fig. 4 are please referred to, Fig. 2 is a kind of functional block diagram of current feedback circuit 109 provided by the embodiment of the present invention two,
Fig. 4 is the circuit diagram of current feedback circuit 109 described in Fig. 3.Current feedback circuit 109 provided in an embodiment of the present invention, including signal hair
Raw circuit 1, electric current output control circuit 2；The output end of the signal generating circuit 1 and the electric current output control circuit 2
Input terminal connection, the output end of the electric current output control circuit 2 with load resistance for connecting；
The signal generating circuit 1, the sawtooth changed for periodically exporting an amplitude by exponential increasing to exponential decrease
Wave voltage signal；
The electric current output control circuit 2 alternately becomes for the sawtooth voltage signal to be converted to polar cycle
The sawtooth current signal of change.
As shown in figure 9, the sawtooth current signal is sail type wave signal, it can specifically pass through the type wave function formula that such as lowers the sail
It indicates:
Wherein t is the time, and y is the amplitude of t moment, and a is amplitude peak, and b is curve initial tangent slope, and 0~T1 is upper
Section is risen, T1~T2 is decaying section, waveform shape can be changed by changing parameter b.
Enable T1=T2=5b=T
As shown in Figure 10, sawtooth current signal is positive the symmetrical two-phase sail type wave of negative cycle, the current feedback circuit 109
By the sawtooth current signal for generating a kind of variation of alternating polarity and amplitude is changed by exponential increasing to exponential decrease, make gout
Therapeutic effect it is more preferable, while circuit structure is simple, at low cost.
The signal generating circuit 1 includes: first microprocessor 11 and the first analog-digital converter 12；First micro process
The signal end of device 11 is connect with the input terminal of first analog-digital converter 12, the output end of first analog-digital converter 11 with
The output end of the signal generating circuit 1 connects.
The electric current output control circuit 2 include: the first polarity control circuit 21, the first current source 22, high voltage power supply 23,
Filter circuit 24；The power control terminal of the first microprocessor 11 is connect with the input terminal of the high voltage power supply 23, the height
The output end of voltage source 23 is connect with the high-voltage electricity source of first current source 22；The polarity of first micro process 11 controls
End is connect with the control terminal of first polarity control circuit 21, the power end of first polarity control circuit 21 and described the
The feedback end of one current source 22 connects；The input terminal of the output end of first analog-digital converter 12 and the filter circuit 24 connects
It connects, the output end of the filter circuit 24 is connect with the input terminal of first polarity control circuit 21, the first polarity control
First output end of circuit 21 processed is connect with the first input end of first current source 22, first polarity control circuit 21
Second output terminal connect with the second input terminal of first current source 22, the first output end of first current source 22 is logical
It crosses positive electrode to connect with the load resistance, the second output terminal of first current source 22 passes through negative electrode and load electricity
Resistance connection.
Preferably, the filter circuit 24 is low-pass filter circuit.
First polarity control circuit 21 includes: signal amplifier 211, transistor M and analog switch 212；It is described
The normal phase input end of signal amplifier 211 is connect with the input terminal of first polarity control circuit 21, the signal amplifier
211 inverting input terminal, the analog switch 212 enable end EN connect with the source electrode of the transistor M, the transistor M
Grid connect with the control terminal of first polarity control circuit 21, the drain electrode of the transistor M and first current source
22 feedback end connection, the output end of the signal amplifier 211 are connect with the input terminal Z of the analog switch 212, the mould
The control terminal S of quasi- switch 212 is connect with the switch control terminal of the first microprocessor 11, and the first of the analog switch 212
Output end Y0It is connect with the first output end of first polarity control circuit 21, the second output terminal Y of the analog switch 2121
It is connect with the second output terminal of first polarity control circuit 21.
Preferably, the signal amplifier 211 is operational amplifier.First polarity control circuit 21 further includes first
Resistance R1, second resistance R2,3rd resistor R3, the both ends of the first resistor R1 respectively with the signal amplifier 211 just
The connection of phase input, output end；The output end of the signal amplifier 211 passes through the second resistance R2 and the analog switch
212 input terminal Z connection；The enable end EN of the analog switch 212 is connected by the 3rd resistor R3 and working power end VDD
It connects.
The current feedback circuit 109 further includes the first detection circuit 3 and the second detection circuit 4, first detection circuit
3, the first input end of second detection circuit 4 is connect with the first output end of first current source 22, and described first
Detection circuit 3, second detection circuit 4 the second input terminal connect with the second output terminal of first current source 22；
First output end of first detection circuit 3 is connect by the positive electrode with the load resistance, the first detection electricity
The second output terminal on road 3 is connect by the negative electrode with the load resistance, the detection output of first detection circuit 3
It is connect with the first test side of the first microprocessor 11；The output end of second detection circuit 4 and described first micro- place
Manage the second test side connection of device 11.
The effect of first analog-digital converter 12 is to generate sail type wave signal；The effect of the filter circuit 24 is to sail
Type wave signal is filtered；The effect of transistor M is the inverting input terminal for controlling the signal amplifier 211 and first electricity
Whether stream source 22 connects and whether the analog switch 212 enables；The effect of the signal amplifier 211 is described in control
The output of first current source；The effect of the analog switch 212 is the positive-negative polarity that control first current source 22 exports electric current；
The effect of the high voltage power supply 23 is to provide high voltage power supply for first current source 22；The effect of first current source 22 is
Generate sail type wave electric current；The effect of first detection circuit 3 be detection load resistance connect with first current source 22 it is whether good
It is good；The effect of second detection circuit 4 is whether the detection operation of the first current source 22 is normal.
The working principle of the current feedback circuit 109 is as follows:
First microprocessor 11 is according to sail type wave function formula, and Δ t programming exports the value of y [n] in regular intervals, specifically
It is as follows:
Wherein n=1,2,3 ...；
Then the value of y [n] is converted into digital signal by the first digital analog converter 12, exports stair-stepping approximate sail type wave
Signal is finally filtered after smoothing processing by filter circuit 24 and obtains sail type wave signal.
When transistor M is in off state, the enabled input terminal EN of analog switch 212 is invalid.The output of input terminal Z and first
Hold Y0, second output terminal Y1Inside disconnects.The first input end and the second input terminal of first current source 22 are without input, therefore first is electric
First output end in stream source 22, second output terminal are without any output.
When transistor M is in the conductive state, the enabled input terminal EN of analog switch 212 is effective, signal amplifier 211 it is anti-
Phase input terminal is connect with the feedback end of the first current source 22.The sail type wave signal that filter circuit 24 exports passes through signal amplifier
After 211 enhanced processing, export to the input terminal Z of analog switch 212.
If the input terminal Z and second output terminal Y of analog switch 2121Inside connection, then sail type wave signal is by simulation
Switch 212 is exported to first the second input terminal of current source.Under the action of sail type wave signal, the first current source 22 is exported from first
End 201 exports sail type wave electric current to load resistance, then returns to the first electric current from second output terminal by the first detection circuit
Source 22.Current feedback circuit 109 completes the output of a positive sail type wave electric current as a result,.
If the input terminal Z and second output terminal Y of analog switch 2120Inside connection, then the sail that filter circuit 24 exports
Type wave signal is exported by analog switch 212 to 22 second input terminal of the first current source.Under the action of sail type wave signal, first
Current source 22 is from second output terminal, by the first detection circuit, exports sail type wave electric current to load resistance, then from the second output
End returns to the first current source 22.Current feedback circuit 109 completes the output of a negative sail type wave electric current as a result,.
It repeats the above steps, at timed intervals Δ T, the period repeatedly exports positive sail type wave and negative sail type wave electric current, is formed
Two-phase multiple groups sail type wave electric current.Its current amplitude is directly proportional to the parameter a of sail type wave function formula, and ratio is fixed；Pulse width
It is determined by the parameter b and T of sail type wave function formula；Pulse frequency is then 1/ Δ T；It can be by 11 programming Control of first microprocessor
State whole parameters.The current feedback circuit 109 is according to the two-phase sail type wave letter for generating a kind of positive and negative periodic symmetry in above-mentioned principle
Number, keep the effect of the prevention and treatment of gout more preferable, while circuit structure is simple, it is at low cost.
Embodiment three
Fig. 5, Fig. 6 are please referred to, Fig. 5 is a kind of functional block diagram of current feedback circuit 109 provided by the embodiment of the present invention three,
Fig. 6 is the circuit diagram of current feedback circuit 109 described in Fig. 5.Current feedback circuit 109 provided in an embodiment of the present invention, including signal hair
Raw circuit 1, electric current output control circuit 2；The output end of the signal generating circuit 1 and the electric current output control circuit 2
Input terminal connection, the output end of the electric current output control circuit 2 with load resistance for connecting；
The signal generating circuit 1, the sawtooth changed for periodically exporting an amplitude by exponential increasing to exponential decrease
Wave voltage signal；
The electric current output control circuit 2 alternately becomes for the sawtooth voltage signal to be converted to polar cycle
The sawtooth current signal of change.
As shown in figure 9, the sawtooth current signal is sail type wave signal, it can specifically pass through the type wave function formula that such as lowers the sail
It indicates:
Wherein t is the time, and y is the amplitude of t moment, and a is amplitude peak, and b is curve initial tangent slope, and 0~T1 is upper
Section is risen, T1~T2 is decaying section, waveform shape can be changed by changing parameter b.
Enable T1=T2=5b=T
As shown in Figure 10, sawtooth current signal is positive the symmetrical two-phase sail type wave of negative cycle, the current feedback circuit 109
By generating a kind of polar cycle sawtooth current signal that alternately variation and amplitude are changed by exponential increasing to exponential decrease,
Keep therapeutic effect more preferable, while circuit structure is simple, it is at low cost.
The signal generating circuit 1 includes the second microprocessor 13 and the first digital analog converter 14；Second micro process
The signal end of device 13 is connect with the input terminal (14a) of first digital analog converter 14, first digital analog converter 14 it is defeated
Outlet is connect with the output end of the signal generating circuit 1.
The electric current output control circuit 2 includes: the second polarity control circuit 25, the second current source 26, channel control electricity
Road 27 and high-voltage inverter circuit 28；The input of the input terminal of second current source 26 and the electric current output control circuit 2
End connection, the output end of second current source 26 is connect with the input terminal of the high-voltage inverter circuit 28, described high-voltage inverted
First output end of circuit 28 is connect with the first input end of second polarity control circuit 25, the high-voltage inverter circuit 28
Second output terminal connect with the second input terminal of second polarity control circuit 25；Second polarity control circuit 25
Two control terminals are connect with two polarity control terminals of second microprocessor 13 respectively, second polarity control circuit 25
The first output end connect with the first input end of the channel control circuit 27, the second of second polarity control circuit 25
Output end is connect with the second input terminal of the channel control circuit 27；First output end of the channel control circuit 27 passes through
Positive electrode is connect with the load resistance, and the second output terminal of the channel control circuit 27 passes through negative electrode and load electricity
Resistance connection.
The high-voltage inverter circuit 28 includes transformer T, inverter circuit 281, filter capacitor C and rectifier 282；It is described
The input tap of transformer T is connect with the output end of second current source 26；Two input terminals of the inverter circuit 281
(281a, 281b) is connect with two inversion control ends of second microprocessor 13 respectively, and the first of the inverter circuit 281
Output end is connect with the first input end of the transformer T, the second output terminal of the inverter circuit 281 and the transformer T
First input end connection；The first output end of the transformer T is connect with the first input end of the rectifier 282, described
The second output terminal of transformer T is connect with the second input terminal of the rectifier 282；First output end of the rectifier 282
It is connect with the first output end of second polarity control circuit 25, the second output terminal of the rectifier 282 and described second
The second output terminal of polarity control circuit 25 connects；The first pole of the filter capacitor C and second polarity control circuit 25
The first output end (25a) connection, the output tap of the transformer T, the filter capacitor C the second pole and second pole
Property control circuit 25 second output terminal (25b) connection.
Preferably, the transformer T includes 2 armature windings and 2 secondary windings.One end of 2 armature windings is conllinear
And connect with the output end of second current source 26, the other end of 2 armature windings respectively with the inverter circuit 281
One output end, second output terminal connection；One end of 2 secondary windings is conllinear and connect with the second pole of the filter capacitor C, 2
The other end of a secondary windings is connect with the first input end of the rectifier 282, second output terminal respectively.
Preferably, second polarity control circuit 25 includes the first photoelectrical coupler 251 and the second photoelectrical coupler
252.The control terminal (251a, 252a) and described second of first photoelectrical coupler 251 and second photoelectrical coupler 252
Microprocessor 13 connects.The input terminal of first photoelectrical coupler 251 is connect with the first output end of rectifier 282；It is described
The input terminal of second photoelectrical coupler 252 is connect with the second output terminal of rectifier 282；First photoelectrical coupler, 251 He
The output end of second photoelectrical coupler 252 is connect with the first pole of filter capacitor C.
Referring to Fig. 7, it is the circuit diagram of the channel control circuit 27.The channel control circuit 27 includes third light
Electric coupler 271, the 4th photoelectrical coupler 272, the 5th photoelectrical coupler 273, the 6th photoelectrical coupler 274；The third light
Electric coupler 271 and the 4th photoelectrical coupler 272 form first passage；5th photoelectrical coupler 273 and described
Six photoelectrical couplers 274 form second channel.Wherein, in first passage, the input terminal of third photoelectrical coupler 271 and filtering
The first pole of capacitor C connects, and the output end of third photoelectrical coupler 271 is connect by positive electrode with load resistance；4th photoelectricity
The input terminal of coupler 272 is connect by negative electrode with load resistance, and the output end (272a) of the 4th photoelectrical coupler 272 passes through
4th resistance R4 is connect with the second pole of the filter capacitor C.In the second channel, the input terminal of the 5th photoelectrical coupler 273
It is connect with the first pole of filter capacitor C, the output end of the 5th photoelectrical coupler 273 is connect by positive electrode with load resistance；The
The input terminal of six photoelectrical couplers 274 is connect by negative electrode with load resistance, and the output end of the 6th photoelectrical coupler 274 passes through
The resistance R is connect with the second pole of the filter capacitor C.
Referring to Fig. 8, it is the circuit diagram of the third detection circuit.The current feedback circuit 109 further includes third inspection
Slowdown monitoring circuit 5, the third detection circuit 5 include isolated amplifier 51, amplifying circuit 52, the second analog-digital converter 53 and the 4th
The first end of resistance R4, the 4th resistance R4, the normal phase input end of the isolated amplifier 51 and the 4th photoelectric coupling
The output end (272a) of device 272 connects, and the second end of the resistance R is connect with the inverting input terminal of the isolated amplifier 51；
51 positive output end of isolated amplifier is connect with the normal phase input end of the amplifying circuit 52, and the isolated amplifier 51 is anti-
Phase output terminal is connect with the inverting input terminal of the amplifying circuit 52；The output end of the amplifying circuit 52 and second modulus
The input terminal of converter 53 connects, output end (53a) and second microprocessor 13 of second analog-digital converter 53
Test side connection.
The effect of first analog-digital converter 14 is to generate sail type wave voltage letter under the programming Control of the second microprocessor 13
Number.The effect of second current source 26 is that sail type wave voltage signal is converted to sail type signal wave current.The effect of transformer T
It is isolation, boosting.The effect of inverter circuit 281 is that sail type signal wave current is reverse into high frequency ac signal.Rectifier 282
Effect is rectified to T grade output of transformer.The effect of second polarity control circuit 25 is the positive and negative of selection output electric current
Polarity.Filter capacitor C effect is filtering.The effect of channel control circuit 27 is selection output channel.The work of third detection circuit 5
With the output for being monitoring current generator 109.
The working principle of the current feedback circuit 109 is as follows:
Second microprocessor 13 is according to sail type wave function formula, and Δ t programming exports the value of y [n] in regular intervals, specifically
It is as follows:
Wherein n=1,2,3 ...；
Then the value of y [n] is converted into analog signal by the first analog-digital converter 14, exports stair-stepping approximate sail type wave
Signal, the approximation sail type wave signal export sail type signal wave current by the second current source 26.
The programming of second microprocessor 13 generates the high-frequency switching signal of 2 groups of opposite in phase, output to the inverter circuit 281
First input end, the second input terminal, sail type signal wave current is reverse into high frequency ac signal, then by transformer T every
It from boosting, is rectified using rectifier 282, filter capacitor C filtering output sail type wave electric current.When the second polarity control circuit 25
When first photoelectrical coupler 251 is opened, output is positive high voltage sail type wave electric current；It is defeated when the second photoelectrical coupler 252 is opened
Out be negative high voltage sail type wave electric current.Δ T at timed intervals, period repeatedly export positive and negative high pressure sail type wave electric current, realize institute
State two-phase multiple groups sail type wave electric current.
When third photoelectrical coupler 271, the 4th photoelectrical coupler 272 of the first passage of the channel control circuit 27 are beaten
It opens, and when the closing of the 5th photoelectrical coupler 273 of second channel, the 6th photoelectrical coupler 274, two-phase multiple groups sail type wave electric current
It is exported to first passage, vice versa.The two-phase multiple groups sail type wave electric current eventually passes through resistance R and returns to filter capacitor C second
Pole, forming circuit.
The third detection circuit 5 passes through the both end voltage signal of monitoring resistor R, then carries out isolation amplification, modulus turns
It the processing such as changes, finally exports to the second microprocessor 13.Second microprocessor 13 is by research and application data, to judge that electric current is sent out
Whether the raw operation of device 109 is normal.The current feedback circuit 109 is according to the two-phase for generating a kind of positive and negative periodic symmetry in above-mentioned principle
Sail type wave signal, the effect for preventing and treating gout is more preferable, while circuit structure is simple, at low cost.
Equipment application embodiment
One, hypertension embodiment
Hypertension is that a kind of pathogenic factors is complicated, the course of disease duration is long and can cause the chronic of vascular system dysfunction
Metabolic disease.Essential hypertension there is no radical cure method, and the final purpose for the treatment of is to reduce hypertensive patient's heart, cerebrovascular disease
The morbidity and mortality of disease.The drug for now commonly using low dose of preferential selection durative action preparation, drug combination and individuation is controlled
It treats.And because the toxic side effect and hypertensive patient's clinical resistance of drug increase.Urgent clinical needs are a kind of safely and effectively, controllable
Treatment method.
Following equipment application embodiment pass through use bionical object electric stimulation rehabilitation method, to CROSS REFERENCE progress regulating blood pressure and
Related complication clinical symptom remission.In following 5 Application Examples, hypertension pathogeny is different, but several patients exist
The case where blood circulation dysfunction and blood vessel physiological property disorder.Wherein 2 hypertensive patients, it is long-term to carry out drug control,
But because of no progress living habit intervention, fluctuation of blood pressure is larger.During rehabilitation, continue to take the same dose of drugs again
In addition the mode of application equipment of the invention, systolic pressure and diastolic pressure have reduction and gentle downward trend occur.Other 3,
It does not take medicine before rehabilitation or discontinuity is taken medicine, do not have clinical reference value.Therefore in the rehabilitation phase, all it is discontinued and adds
It is treated with prevention and treatment hypertension equipment of the invention, is found by periodical follow-up observation, fluctuation of blood pressure tends to be steady.Therefore, I
Think to be positively correlated using rehabilitation result of the present invention treatment for essential hypertension, electro photoluminescence can excited vascular smooth muscle
Cell generates action potential and promotes vessel retraction, reduces peripheral resistance petty action astillen/chamber ratio by increase tube wall elasticity reduction outer
All vascular resistences, so that position and the reflection wave strength of Radinal pressure reflection point are influenced, pulse pressure difference caused by alleviating because of hypertension.
Typical case 1: female Lee 37 years old.
The cause of disease: causing the cause of disease of hypertension: having family history of hypertension, and there are peripheral circulation disorders (poor circulations).
Diagnostic result: TSH more years, no pharmacohistory only carried out diet control (less salt low fat), but controlled not stringent.Blood pressure wave
It moves in 75~85mmHg of 145~150mmHg of systolic pressure and (or) diastolic pressure
Relevant parameter: using the equipment of prevention and treatment hypertension of the invention, surface electrode is for contacting abdominal aorta body surface
Nearby skin, the sawtooth wave for the alternating polarity variation that the current feedback circuit is exported are electric for subpoint, rete arteriosum dorsale pedis traveling
It flows signal transduction to underlying nerve and carries out electro photoluminescence, specific frequency is 3Hz, pulsewidth 3ms, plateau time 20s, remaining time
For 0s, current waveform is two-phase multiple groups sail type wave.
Therapeutic process: low-frequency therapeutic 60 days, 1~2 times/day, 30~60min/ times.110~135mmHg of systolic pressure and (or)
80~85mmHg of diastolic pressure
It is not taken drugs during low-frequency therapeutic, diet control and related life habit are the same as before.And in the treatment end of term
Tip dyshaemia is alleviated.
Case 2: Hu male 55 years old
The cause of disease: circulatory function obstacle, dietary structure is unstable and bad life habits.
Diagnostic result: for many years, long-term agents control hypertension.Fluctuation of blood pressure is in 160~169mmHg of systolic pressure and (or) relaxes
Open 100~110mmHg of pressure
Treatment: relevant parameter: using the equipment of prevention and treatment hypertension of the invention, surface electrode is for contacting abdominal aorta
Skin near body surface projection point, rete arteriosum dorsale pedis traveling, the sawtooth for the alternating polarity variation that the current feedback circuit is exported
Signal wave current conduct to underlying nerve carry out electro photoluminescence, specific frequency be 2Hz, pulsewidth 3ms, plateau time 20s, remaining
Time is 0s, and current waveform is two-phase multiple groups sail type wave.
Therapeutic process: low-frequency therapeutic 145 days, 1~2 times/day, 30~60min/ times.130~150mmHg of systolic pressure and
(or) 85~95mmHg of diastolic pressure
It is taken drugs during low-frequency therapeutic, adjustment of diet (but unstable adhere to).Blood pressure tends to be steady, and follows the doctor's advice
Reduce hypertension drug.
Case 3: Zhang male 29 years old
The cause of disease: circulatory function obstacle merges obesity
Diagnostic result: obesity merges three high (hypertension, hyperlipidemia, hyperglycemia), does not take drugs, does not carry out blood pressure control
System.Fluctuation of blood pressure is in 92~100mmHg of 143~151mmHg of systolic pressure and (or) diastolic pressure
Treatment: relevant parameter: using the equipment of prevention and treatment hypertension of the invention, surface electrode is for contacting abdominal aorta
Skin near body surface projection point, rete arteriosum dorsale pedis traveling, the sawtooth for the alternating polarity variation that the current feedback circuit is exported
Signal wave current conduct to underlying nerve carry out electro photoluminescence, specific frequency be 1Hz, pulsewidth 3ms, plateau time 20s, remaining
Time is 0s, and current waveform is two-phase multiple groups sail type wave.
Therapeutic process: low-frequency therapeutic 216 days, 1~2 times/day, 30~60min/ times.127~134mmHg of systolic pressure and
(or) 82~90mmHg of diastolic pressure
It is not taken drugs during low-frequency therapeutic.Pressure value lowers and tends to be steady.
Case 4: Zhao female 71 years old
The cause of disease: blood circulation disorder, the decline of blood vessel physiological property, hormonal readiness are unstable
Diagnostic result: persistently medication (take drugs enumerate as follows: Losartan Tablet) is diagnosed as after hypertension.Fluctuation of blood pressure
In 110~123mmHg of 150~165mmHg of systolic pressure and (or) diastolic pressure
Treatment: relevant parameter: using the equipment of prevention and treatment hypertension of the invention, surface electrode is for contacting abdominal aorta
Skin near body surface projection point, rete arteriosum dorsale pedis traveling, the sawtooth for the alternating polarity variation that the current feedback circuit is exported
Signal wave current conduct to underlying nerve carry out electro photoluminescence, specific frequency be 1Hz, pulsewidth 3ms, plateau time 20s, remaining
Time is 0s, and current waveform is two-phase multiple groups sail type wave.
Therapeutic process: low-frequency therapeutic 342 days, 1~2 times/day, 30~60min/ times.137~142mmHg of systolic pressure and
(or) 90~97mmHg of diastolic pressure
It is taken drugs during low-frequency therapeutic.Otherwise adjustment is not carried out, and blood pressure is declined and tended to be steady.
Case 5: Mr. Wang female 59 years old
The cause of disease: cause the cause of disease of hypertension: circulatory function obstacle, stress is excessively high, dietary structure, living habit
Etc. related.
Diagnostic result: in the case where antihypertensive drugs is not used 150~160mmHg of systolic pressure and (or) diastolic pressure 95~
110mmHg
Treatment: low-frequency electrostimulating treatment: relevant parameter: using the equipment of prevention and treatment hypertension of the invention, surface electrode
For contacting abdominal aorta body surface projection point, skin near rete arteriosum dorsale pedis traveling, the pole that the current feedback circuit is exported
Property alternately variation sawtooth current signal transduction to underlying nerve carry out electro photoluminescence, specific frequency be 3Hz, pulsewidth 3ms, put down
The platform time is 20s, remaining time is 0s, and current waveform is two-phase multiple groups sail type wave.
Therapeutic process: low-frequency therapeutic 120 days, 1~2 times/day, 50min/ times.120~132mmHg of systolic pressure and (or) relax
Open 70~85mmHg of pressure
Do not taken drugs during low-frequency therapeutic, take drugs before this control blood pressure (but fluctuation of blood pressure it is larger and shrink
Pressure is constantly within the scope of normal high level or slight high level).
Pass through the use of above-mentioned several patients, the results showed that, using the equipment low frequency electricity of prevention and treatment hypertension of the invention
Stimulation therapy hypertension, through Canonical management after a period of time, most of patients can reduce diastolic pressure and systolic pressure more significantly,
And it is adjusted to normal blood pressure level, pass through the therapeutic effect of drug for hypertension more preferably before compared with patient.
Two, fat embodiment
The present invention prevents and treats fat equipment and takes low frequency neuromuscular treatment (or imitative bioelectric stimulation) by vascular system
The improvement for physiological function of uniting improves endocrine factor unstable state, to carry out weight to accelerate body metabolism circulation
The improvement of control and obesity symptom.The present invention chooses volunteer and implements correlation test treatment, preferable effect is obtained, not
The case where changing living habit, dietary structure, not taking other treatment measure simultaneously, volunteer's weight has a degree of subtract
Gently, body fat rate has a degree of decline.
Below in 5 embodiments, using the fat equipment low frequency of prevention and treatment of the invention carry out circulatory function improve to
The steady decline of weight, body fat rate is reached, and according to contrast before and after treatment, body index is down to normal range (NR), exists simultaneously
Its relevant clinical detection data of the personnel of fat related complication (if any hypertension caused by obesity, hyperlipidemia etc.) is also put down
Steady decline.
5 acquisition weight loss, body fat rate reduce, BMI value tends to normal case and is described below:
The cause of disease:
1,1 patient age was at 24 years old (Mr. Wang-male).Cause the fat cause of disease: with metabolic cycles, living habit, diet
Structure is related.
2,1 patient age was at 59 years old (Mr. Wang-female).Cause the fat cause of disease: under blood circulation, hormonal readiness
Drop, stress is excessively high, and dietary structure is related.
3,1 patient age was at 35 years old (remaining certain-female).Cause the fat cause of disease: living and diet is irregular, metabolic cycles barrier
Hinder, habit of staying up late,
4,1 patient age was at 40 years old (Mr. Lin-female): metabolic cycles are bad, unreasonable diet structure.
5,1 patient age 33 years old (marquis so-and-so-male): live irregular, unreasonable diet structure, poor circulation
(there are peripheral circulation disorders).
Diagnostic result:
1,1 (Mr. Wang-male) height 180cm, weight 140KG, body fat rate 41, BMI value 43.2.Belong to primary obesity.
And there are the complication such as high lithemia caused by obesity, hyperlipidemia.
2,1 (Mr. Wang-female) height 158cm, weight 72KG, body fat rate 28.8.Central obesity
3,1 (remaining certain-female) height 165cm, weight 80KG, BMI value 29.4.Primary is fat and with Central obesity is
It is main.
4,1 (Mr. Lin-female) height 156cm, weight 71.3KG, BMI value 29.2 is overweight.
5,1 (marquis so-and-so-male) height 158cm, weight 70KG, BMI value 28 is overweight.
Treatment:
Therapeutic modality: by the output end of electro photoluminescence detection module of the present invention and the output end of the current feedback circuit
It is connect respectively by the current output interface module with the surface electrode, the surface electrode is for contacting two sides femoral artery
And/or at vein and two sides dorsal venous rete of foot, the sawtooth current for the alternating polarity variation that the current feedback circuit is exported
Signal transduction to underlying nerve carries out electro photoluminescence.
Relevant parameter: frequency 4Hz, pulsewidth 4ms, plateau time 20s, remaining time are 0s, and current waveform is double
Phase multiple groups sail type wave.Daily 1~2 time.30~60min/ times, 30~62 days.
Three, diabetes embodiment
Diabetes are one group and knit multiple organs dysfunction especially eye, kidney, heart, blood vessel, nerve with hyperglycemia, multiple groups
The metabolic disease that chronic lesion is characterized.Use bionical physics electro photoluminescence induction Skeletal Muscle Contraction can be in this application embodiment
The phosphorylation level for improving skeletal muscle PI3K and Akt albumen, to activate PI3k and Akt.By increasing bone muscle flow, change
The sensibility of kind skeletal muscle, towards insulin promotes the absorption of glucose and utilizes the associated clinical symptoms so as to improve diabetes.
Reduce fat content in the abdomen for generating insulin resistance simultaneously, reduces fat cell, insulin receptor number on histocyte
Mesh increases, and activity is enhanced, to increase the sensibility of insulin.3 volunteers, are controlled by the rehabilitation of different time
It treats, makes blood glucose value control in a certain range, exist simultaneously the patient of each systematic complication as caused by diabetes, simultaneously
Hair disease has also obtained corresponding improvement (part be only subject to patient main suit).Therefore carrying out bionical physics electronic stimulation for a long time can have
Effect auxiliary improves metabolic risk and follow-up effect is substantially better than simple rehabilitation.
(1) relevant parameter: frequency 1-6Hz, pulsewidth 4ms, plateau time 20s, remaining time are 0s, current waveform
For two-phase multiple groups sail type wave.
(2) therapeutic process: the equipment for taking present invention prevention and treatment diabetes generates positive and negative for the current feedback circuit 109
The sail type wave signal of the two-phase of periodic symmetry is transmitted to subcutis by surface electrode, double by the way that surface electrode to be bonded
Flank rectus, (peripheral nerve reflection function improves prevention all kinds of complication as caused by hyperglycemia, and nerve impulse conduction speed increases
Fastly.) and have the function that glycemic control.
1, Mrs department, 31 years old.Type II diabetes, cause the cause of disease of diabetes: inherent cause, obesity etc. cause pancreas islet B thin
Born of the same parents' dysfunction.
1. symptom and diagnosis:
There is type II diabetes, drink, diuresis eat more more, but weight is not decreased obviously.It is oral sulfonylurea drugs, double
Guanidine antidiabetic drug, fasting blood-glucose fluctuation larger (float between 6.3~8.9mmol/L) more.There are diabetic peripheral neuropathies
Become (left lower extremity temperature sensation is abnormal, and ankle jerk disappears, and lower limb nerve conduction of velocity extends)
2. therapeutic process:
Relevant parameter: frequency 1-2Hz, pulsewidth 4ms, plateau time 20s, remaining time are 0s, and current waveform is
Two-phase multiple groups sail type wave.
Low-frequency therapeutic 57 days, 1 times/day, 60~120min/ times.
3. treatment results:
Dosage is taken drugs during treatment and type does not change.Survey fasting blood-glucose fluctuation range 5.4~6.7mmol/L it
Between.Lower limb nerve conduction of velocity restores normal, while ankle jerk is established.
2, Wan Nvshi, 73 years old.Type I diabetes, cause the cause of disease of diabetes: metabolic cycles obstacle, self immune system lack
It falls into
1. symptom and diagnosis:
There is typical and three-many-one-little and symptom, weight are decreased obviously.Insulin injection 1 year or so.Fasting blood-glucose fluctuation
It is larger (float between 6.1~9.5mmol/L) more.There are coronary heart disease (coronary atherosclerosis is obvious)
2. therapeutic process:
Relevant parameter: frequency 3-4Hz, pulsewidth 4ms, plateau time 20s, remaining time are 0s, and current waveform is
Two-phase multiple groups sail type wave.
Low-frequency therapeutic 203 days, 1~2 times/day, 60~120min/ times.
3. treatment results:
Dosage is taken drugs during treatment and type does not change.Survey fasting blood-glucose fluctuation range 6.0~7.2mmol/L it
Between.Main suit's angina pectoris incidence reduces during treatment, almost without breaking-out.
3, Mr. Zhang, 49 years old.Type II diabetes causes the cause of disease of diabetes: metabolic cycles obstacle, obesity etc..
1. symptom and diagnosis:
It is only slight out of strength, thirsty.Between 7.8~10.5mmol/L of fasting blood-glucose.Do not occur corresponding complication
2. therapeutic process:
Relevant parameter: frequency 1-2Hz, pulsewidth 4ms, plateau time 20s, remaining time are 0s, and current waveform is
Two-phase multiple groups sail type wave.
Low-frequency therapeutic 105 days, 1 times/day, 50min/ times.
3. treatment results:
It is not taken drugs during treatment.Fasting blood-glucose fluctuation range is surveyed between 7.1~7.7mmol/L.Main suit's correlation disease
Shape mitigates.
Pass through the use of above-mentioned several patients, the results showed that, using the equipment low frequency electricity of prevention and treatment diabetes of the invention
Stimulation therapy diabetes, by the rehabilitation of different time, make blood glucose value control in a certain range, exist simultaneously by
The patient of each systematic complication caused by diabetes, complication has also obtained corresponding improvement, and (part is only with patient main suit
It is quasi-).Therefore it carries out bionical physics electronic stimulation for a long time and can effectively assist improving metabolic risk and follow-up effect to be substantially better than
Simple rehabilitation.
Four, caput femoris necrosis embodiment
Caput femoris necrosis, that is, avascular necrosis of femoral head, also referred to as aseptic necrosis of femoral head.It is due to blood supply of the femoral head
It interrupts or impaired, causes osteocyte, marrow stromal cell and fat cell necrosis that femur header structure is then caused to change, femoral head
It collapses, the disease of joint function disturbance.There is blood circulation near hip joint caused by due to a variety of causes in the present embodiment
Dysfunction, to related avascular necrosis of femoral head clinical symptoms occur.Imitative bioelectric stimulation electricity is exported by stimulating electrode
Stream makes film vascular smooth muscle in abdominal aorta tube wall that it be made passively to shrink diastole, increases elastic reservoir blood vessel in left ventricular contraction
It penetrates the blood phase and injects the artery blood volume of periphery, while guaranteeing largely to be converted to systaltic elastic potential energy in diastole dynamic
Can, extend ejection time and increases peripheral blood blood volume.And enhance the expansion of film elastomer and retraction in tube wall, according to poiseuille
Law increases blood flow by increasing vessel radius and blood vessel pressure at two ends difference in the case where blood viscosity is constant.It is placed in two parapodums
The electrode of the quiet and secluded network of vein directly acts on vein smooth muscle and it is promoted to shrink diastole, increase when exporting imitative bioelectric stimulation
Strong veins of lower extremity pumps physiological function, and excitation portion muscle pump physiological function increases venous return.Increased by two arrays of electrodes
Peripheral arterial blood volume, venous return accelerate blood circulation.Improve the blood circulation of femoral head surrounding tissue and enhances Nutrition Unit
Bone artery flow velocity, so that bone necrosis caused by alleviating because of ischemic, alleviate associated clinical symptoms.4 embodiments are suffered from
Person is alleviated by rehabilitation, main suit's pain symptom, and joint motion is limited to be released in various degree, while being influenced to learn and being checked display
Local necrosis area reduces, haemodynamics tends to normally, therefore the bionical physics electronic stimulation of deducibility is for ischemic femoral head
Property necrosis prevention and clinical rehabilitation effect be positively related.
4 volunteers obtain the improvement of femoral head local blood circulation function, avascular necrosis of femoral head relevant clinical body
The case that sign mitigates is described below:
1, Mr. Wang, 37 years old.Cause the cause of disease of avascular necrosis of femoral head: local blood circulation dysfunction has and drinks
History.
1. symptom and diagnosis:
Right lateral thigh adjacent bone is in slight radiated pain, and the course of disease continues 1 year.Feeling of pain is aggravated after drinking, and nearly half a year goes out
Existing right leg hip joint limitation of activity, inward turning limitation of activity.Imageological examination is shown MRI (+), is diagnosed in II b of necrosis area,
2. therapeutic process:
Scheme: frequency 1Hz, pulsewidth 1ms, plateau time 20s, remaining time are 0s, and current waveform is that two-phase is more
Group sail type wave.
Low-frequency therapeutic 95 days, 2 times/day, 40~60min/ times.
3. treatment results:
Main suit's feeling of pain gradually weakens, and joint motion is limited to be released.MRI checks in I a of necrosis area that CT (-), pathology is shown
Show only part osteocyte necrosis.
2, Zhou Xiansheng, 41 years old.Cause the cause of disease of avascular necrosis of femoral head: trauma history (it lies in bed after wound half a year, lower limb blood
Liquid circulation be obstructed), history of drinking history.
1. symptom and diagnosis:
Lie up after tumble injury 6 months or so, after in hospital carry out further consultation.Image examinations showed: MRIT2W1 suppression rouge shows
Bone marrow edema, CT show that subchondral bone is rolled over, and walk lamely obvious, severe in pain.
2. therapeutic process:
Scheme: frequency 2Hz, pulsewidth 1ms, plateau time 20s, remaining time are 0s, and current waveform is that two-phase is more
Group sail type wave.
Low-frequency therapeutic 158 days, 2 times/day, 60~90min/ times.
3. treatment results: main suit's feeling of pain gradually weakens, and walks lamely and mitigates.MRI checks that meniscus sign accounts for articular surface length by III C
Greatly, it is small to be changed into III C.
3, Li Xiansheng, 59 years old.Cause the cause of disease of avascular necrosis of femoral head: blood circulation dysfunction, because suffering from erythema wolf
Sore is treated and (has been used containing glucocorticoid medicine) for many years.
1. symptom and diagnosis:
There is more serious feeling of pain in left hip, and discontinuity is walked lamely, and inward turning is limited.Image examinations showed:
MRIT1W1: band-like low signal wrapping fat.
2. therapeutic process:
Scheme: frequency 3Hz, pulsewidth 1ms, plateau time 20s, remaining time are 0s, and current waveform is that two-phase is more
Group sail type wave.
Low-frequency therapeutic 118 days, 1~2 times/day, 30~90min/ times.
3. treatment results: main suit's feeling of pain gradually weakens, and walks lamely and mitigates.MRI checks that meniscus sign disappears, and there is only necrosis
Stove.
4, Zhao Nvshi, 32 years old.Cause the cause of disease of avascular necrosis of femoral head: blood circulation dysfunction, metabolic cycles barrier
Hinder.
1. symptom and diagnosis:
Non-evident sympton, MRI (+), hip joint local blood are obstructed when physical examination.
2. therapeutic process:
Scheme: frequency 4Hz, pulsewidth 1ms, plateau time 20s, remaining time are 0s, and current waveform is that two-phase is more
Group sail type wave.
Low-frequency therapeutic 50 days, 1~2 times/day, 30~40min/ times.
3. treatment results: because of working principle, keeping sitting posture for a long time, and do not like movement.Main suit's double lower limb is heavy after treatment
Double infection mitigates,.MRI (-), hip joint local blood circulation restore normal.
Five, gout embodiment is prevented and treated
Present device embodiment passes through the imitative bioelectric stimulation of application, changes caliber and promotes blood flow velocity, improves venous pump
Function promotes peripheral blood circulation.Accelerate the discharge of body metabolism waste, alleviate patient with gout serum uric acid level, so as to improve pain
Wind related symptoms.The contraction of skeletal muscle can indirectly temper periarticular muscles and ligament tissue, caused by improving because of gout
After joint motion is limited, the useless situation of functional structure.1-6HZ low-frequency electrostimulating is placed at volunteer's affected joints simultaneously
Electrode exports bionical physics electro photoluminescence activation periaqueductal gray matter-oblongata head end ventromedial nucleus-spinal cord pain Top-down effects
Access, and endogenous morphine-like peptides is discharged, while activating the A δ fiber and C of smaller subcutaneous diameter, the conduction pain sensation and the sense of heat fine
Dimension is to reach analgesic and (or) lenitive effect.
In this application embodiment, 4 volunteer patients exist and gout sign occur because of metabolic cycles obstacle, are answering
Pain scores reduce after having carried out the rehabilitation of a period of time with imitative bioelectric stimulation, and corresponding clinical examination data tend to just
Often, and patient is helped to alleviate the related symptoms such as joint motion is limited.Simultaneously for the prevention effect of the intermittent attack of gout
It is also highly effective.
4 patients obtain blood uric acid value reduction, gout associated clinical symptoms mitigate, and are described in detail below:
The cause of disease:
1,1 patient age was at 24 years old (Mr. Wang-male).Cause the cause of disease of gout: living habit, metabolic cycles obstacle, drink
It is related to eat structure.
2,1 patient age was at 69 years old (what certain-male).Cause the cause of disease of gout: there are wound, metabolic cycles function is low
Under and occur in high purine and after drinking.
3,1 patient age was at 35 years old (thank so-and-so-male).Cause the cause of disease of gout: blood circulation function is poor, diet knot
Structure, drink and the high purine diet of high protein after occur.
4,1 patient age was 42 years old (week so-and-so-male).Cause the cause of disease of gout: there are blood circulation dysfunction and
Metabolic cycles dysfunction.
Diagnostic result:
1,1 (Mr. Wang) without obvious gout sign, only blood uric acid is higher for a long time.
2,1 (what certain) blood uric acid value is higher than normal value, but gout sign is obvious.Right crus of diaphragm first waste time plantar arthritis pain it is bright
It is aobvious, limitation of activity, and there is tophus.
3,1 (thanking so-and-so) blood uric acid value fluctuation increases, and gout sign is obvious.Ankle red and swollen heat pain, function barrier
Hinder.
4,1 (week so-and-so) acute stage blood uric acid duration increases, and has uric acid kidney stone (surgical removal history).Involvement
Joint acute stage function limitation.
Treatment:
Mr. Wang
Drug therapy:
Drug type: colchicin, fragrant cloth statin, liver-protecting tablet.
Therapeutic process: drug therapy 343 days, medication amount followed the doctor's advice (2~3 times/day).Blood uric acid value 605umol/l~
521umol/l (without drink, smoking history and treat during adjustment of diet, without high purine and high-protein diet, moderate exercise is not
It stays up late)
Low-frequency electrostimulating treatment:
Relevant parameter: frequency 6Hz, pulsewidth 6ms, plateau time 20s, remaining time are 0s, and current waveform is double
Phase multiple groups sail type wave.
Therapeutic process: low-frequency therapeutic 82 days, 2 times/day, 40min/ times.As a result blood uric acid value 521umol/l~254umol/
L, during treatment without drink, smoking history and treat during adjustment of diet, without high purine and high-protein diet, moderate exercise is not
It stays up late, treatment of being discontinued.
What certain:
Drug therapy:
Acute attack stage: brufen (antalgica), Indomethacin
Therapeutic process: drug therapy 7~9 days, dose was followed the doctor's advice.480~540umol/l of blood uric acid value --- 410~
420umol/l
(high purine food is prohibited in alcohol prohibition)
Low-frequency electrostimulating treatment:
Scheme one:
Relevant parameter: frequency 10HZ, pulsewidth 240ms postpone 10 seconds, rising 0, and plateau time 20 seconds, fall time 10 seconds,
Current waveform is rectangle unidirectional pulse.
Therapeutic process: low-frequency therapeutic 7~9 days, 2~3 times/day.40~60min/ times.Blood uric acid value is unchanged, and pain subtracts
It is weak.
Scheme two:
Frequency is 6Hz, pulsewidth 6ms, plateau time 20s, remaining time is 0s, and current waveform is two-phase multiple groups sail type
Wave.
Therapeutic process: low-frequency therapeutic 3~7 days (continuous treatment).2 times/day, 40~60min/ times.Blood uric acid value can be stablized
Be down to 420umol/l or hereinafter, treatment during be discontinued, keep on a diet, no drinking.
Thank so-and-so
Without medication, only in acute gout arthritis, (acute hair does phase blood uric acid value: 450umol/l, carries out low-frequency electrostimulating
Treatment:
Relevant parameter: frequency 6Hz, pulsewidth 6ms, plateau time 20s, remaining time are 0s, and current waveform is double
Phase multiple groups sail type wave.
Therapeutic process: acute attack stage daily 1~2 time, 20~30min/ times.Blood uric acid value fluctuation 397~
The section 409umol/l, main suit, which keenly feels, to mitigate, and is that can carry out a small amount of activity by limited alleviate of completeness joint motion.
4, week so-and-so
Without medication, there is calculus sign (surgical removal).Drink or high purine diet after occur acute articular involvement carry out
Low-frequency electrostimulating treatment
Relevant parameter: frequency 6Hz, pulsewidth 6ms, plateau time 20s, remaining time are 0s, and current waveform is double
Phase multiple groups sail type wave.
Therapeutic process: acute attack stage 1 time a day, 1 30~60min.Do not monitor blood uric acid value, main suit adhere to 30 days it is every
It is continuous to treat, and when the risk factors such as drink occur, the probability that gout occurs is reduced.
Pass through the use of above-mentioned several patients, the results showed that, there is gout sign because of metabolic cycles obstacle,
Pain scores reduce after having carried out the rehabilitation of a period of time using imitative bioelectric stimulation, corresponding clinical examination
Data tend to normally, and patient is helped to alleviate the related symptoms such as joint motion is limited.
For the present invention as therapeutic equipment, medical worker can choose other positions for being suitble to low-frequency electrostimulating, it might even be possible to
The parameter for adjusting electro photoluminescence, can also take different parameter and the course for the treatment of according to the tolerance of different patients.These difference ginsengs
Number, the course for the treatment of, site of action belong to protection scope of the present invention on the basis of not departing from the principle of the present invention.
The above is a preferred embodiment of the present invention, it is noted that for those skilled in the art
For, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also considered as
Protection scope of the present invention.
Claims (11)
1. a kind of therapeutic equipment characterized by comprising primary processor, display module, key module, power module, USB connect
Mouth mold block, current output interface module, memory, electro photoluminescence detection module, surface electrode and current feedback circuit；The display
Module, the key module, the power module, the usb interface module, the memory, the electro photoluminescence detection module
Input terminal and the input terminal of the current feedback circuit connect respectively with the primary processor, the electro photoluminescence detection module
The output end of output end and the current feedback circuit is connected by the current output interface module and the surface electrode respectively
It connects, the sawtooth current signal transduction that the alternating polarity that the surface electrode exports the current feedback circuit changes to subcutaneous mind
Through carrying out electro photoluminescence.
2. therapeutic equipment as described in claim 1, which is characterized in that the current feedback circuit includes: signal generating circuit, electricity
Flow output control circuit；The output end of the signal generating circuit is connect with the input terminal of the electric current output control circuit, institute
The output end of electric current output control circuit is stated for connecting with load resistance；
The signal generating circuit, the sawtooth voltage changed for periodically exporting an amplitude by exponential increasing to exponential decrease
Signal；
The electric current output control circuit, for the sawtooth voltage signal to be converted to the saw that polar cycle alternately changes
Tooth signal wave current.
3. therapeutic equipment as claimed in claim 2, which is characterized in that the signal generating circuit includes: first microprocessor
With the first analog-digital converter；The signal end of the first microprocessor is connect with the input terminal of first analog-digital converter, institute
The output end for stating the first analog-digital converter is connect with the output end of the signal generating circuit.
4. therapeutic equipment as claimed in claim 3, which is characterized in that the electric current output control circuit includes: the first polarity
Control circuit, the first current source, high voltage power supply, filter circuit；The power control terminal of the first microprocessor and the high pressure
The input terminal of power supply connects, and the output end of the high voltage power supply is connect with the high-voltage electricity source of first current source；Described
The polarity control terminal of one micro process is connect with the control terminal of first polarity control circuit, first polarity control circuit
Power end is connect with the feedback end of first current source；The output end of first analog-digital converter and the filter circuit
Input terminal connection, the output end of the filter circuit are connect with the input terminal of first polarity control circuit, first pole
First output end of property control circuit is connect with the first input end of first current source, first polarity control circuit
Second output terminal is connect with the second input terminal of first current source, and the first output end of first current source passes through positive electricity
Pole is connect with the load resistance, and the second output terminal of first current source is connect by negative electrode with the load resistance.
5. therapeutic equipment as claimed in claim 4, which is characterized in that first polarity control circuit includes: signal amplification
Device, transistor and analog switch；The input of the normal phase input end of the signal amplifier and first polarity control circuit
End connection, the inverting input terminal of the signal amplifier, the analog switch enable end connect with the source electrode of the transistor,
The grid of the transistor is connect with the control terminal of first polarity control circuit, the drain electrode of the transistor and described first
The feedback end of current source connects, and the output end of the signal amplifier is connect with the input terminal of the analog switch, the simulation
The control terminal of switch is connect with the switch control terminal of the first microprocessor, the first output end of the analog switch with it is described
First output end of the first polarity control circuit connects, the second output terminal of the analog switch and first polarity control electricity
The second output terminal on road connects.
6. therapeutic equipment as claimed in claim 4, which is characterized in that the current feedback circuit further include the first detection circuit and
Second detection circuit, first detection circuit, second detection circuit first input end with first current source
The first output end connection, first detection circuit, second detection circuit the second input terminal with it is described first electricity
The second output terminal in stream source connects；First output end of first detection circuit passes through the positive electrode and the load resistance
The second output terminal of connection, first detection circuit is connect by the negative electrode with the load resistance, first inspection
The detection output of slowdown monitoring circuit is connect with the first test side of the first microprocessor；The output end of second detection circuit
It is connect with the second test side of the first microprocessor.
7. therapeutic equipment as claimed in claim 2, which is characterized in that the signal generating circuit include the second microprocessor and
First digital analog converter；The signal end of second microprocessor is connect with the input terminal of first digital analog converter, described
The output end of first digital analog converter is connect with the output end of the signal generating circuit.
8. therapeutic equipment as claimed in claim 7, which is characterized in that the electric current output control circuit includes: the second polarity
Control circuit, the second current source, channel control circuit and high-voltage inverter circuit；The input terminal of second current source with it is described
The input terminal of electric current output control circuit connects, the output end of second current source and the input terminal of the high-voltage inverter circuit
Connection, the first output end of the high-voltage inverter circuit is connect with the first input end of second polarity control circuit, described
The second output terminal of high-voltage inverter circuit is connect with the second input terminal of second polarity control circuit；The second polarity control
Two control terminals of circuit processed are connect with two polarity control terminals of second microprocessor respectively, the second polarity control
First output end of circuit is connect with the first input end of the channel control circuit, and the second of second polarity control circuit
Output end is connect with the second input terminal of the channel control circuit；First output end of the channel control circuit passes through positive electricity
Pole is connect with the load resistance, and the second output terminal of the channel control circuit is connected by negative electrode and the load resistance
It connects.
9. therapeutic equipment as claimed in claim 8, which is characterized in that the high-voltage inverter circuit includes transformer, inversion electricity
Road, filter capacitor and rectifier；The input tap of the transformer is connect with the output end of second current source；It is described inverse
Two input terminals on power transformation road are connect with two inversion control ends of second microprocessor respectively, and the of the inverter circuit
One output end is connect with the first input end of the transformer, and the of the second output terminal of the inverter circuit and the transformer
The connection of one input terminal；First output end of the transformer is connect with the first input end of the rectifier, the transformer
Second output terminal is connect with the second input terminal of the rectifier；First output end of the rectifier and the second polarity control
First output end of circuit processed connects, the second output of the second output terminal of the rectifier and second polarity control circuit
End connection；First pole of the filter capacitor is connect with the first output end of second polarity control circuit, the transformer
Output tap, the filter capacitor the second pole connect with the second output terminal of second polarity control circuit.
10. therapeutic equipment as claimed in claim 8, which is characterized in that the current feedback circuit further includes third detection circuit,
The third detection circuit includes isolated amplifier, amplifying circuit, the second analog-digital converter and the 4th resistance, the 4th electricity
The first end of resistance, the isolated amplifier normal phase input end and the 4th photoelectrical coupler in the channel control circuit it is defeated
Outlet connection, the second end of the 4th resistance are connect with the inverting input terminal of the isolated amplifier；The isolated amplifier
Positive output end is connect with the normal phase input end of the amplifying circuit, the isolated amplifier reversed-phase output and amplification electricity
The inverting input terminal on road connects；The output end of the amplifying circuit is connect with the input terminal of second analog-digital converter, described
The output end of second analog-digital converter is connect with the test side of second microprocessor.
11. therapeutic equipment as claimed in claim 2, which is characterized in that the output current parameters of the current feedback circuit are as follows: frequency
Rate is 1-6Hz, pulsewidth 1-6ms, delay time 0-120s, rise time 0-10s, plateau time 0-30s, fall time
For 0-10s, time of having a rest 0-30s.
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821313949 | 2018-08-15 | ||
| CN201821313950 | 2018-08-15 | ||
| CN201821313915 | 2018-08-15 | ||
| CN2018213139158 | 2018-08-15 | ||
| CN2018213139497 | 2018-08-15 | ||
| CN201821313783 | 2018-08-15 | ||
| CN2018213137839 | 2018-08-15 | ||
| CN2018213138920 | 2018-08-15 | ||
| CN201821313892 | 2018-08-15 | ||
| CN201821313950X | 2018-08-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110368585A true CN110368585A (en) | 2019-10-25 |
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ID=68259158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910749396.2A Pending CN110368585A (en) | 2018-08-15 | 2019-08-14 | A kind of therapeutic equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110368585A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112023265A (en) * | 2020-09-28 | 2020-12-04 | 杭州神络医疗科技有限公司 | Electrical stimulation device |
-
2019
- 2019-08-14 CN CN201910749396.2A patent/CN110368585A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112023265A (en) * | 2020-09-28 | 2020-12-04 | 杭州神络医疗科技有限公司 | Electrical stimulation device |
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Application publication date: 20191025 |