CN110368572A - A kind of catheter and preparation method thereof of achievable long-acting slow-release administration functions - Google Patents
A kind of catheter and preparation method thereof of achievable long-acting slow-release administration functions Download PDFInfo
- Publication number
- CN110368572A CN110368572A CN201910399886.4A CN201910399886A CN110368572A CN 110368572 A CN110368572 A CN 110368572A CN 201910399886 A CN201910399886 A CN 201910399886A CN 110368572 A CN110368572 A CN 110368572A
- Authority
- CN
- China
- Prior art keywords
- urethral catheterization
- groove
- drug
- catheter
- supervisor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
- A61M25/0015—Making lateral openings in a catheter tube, e.g. holes, slits, ports, piercings of guidewire ports; Methods for processing the holes, e.g. smoothing the edges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0496—Urine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1078—Urinary tract
- A61M2210/1085—Bladder
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a kind of medical instruments for urethral catheterization, and in particular to a kind of catheter and preparation method thereof of achievable long-acting slow-release administration functions.To solve the problems, such as the problems such as introducing coating existing in the prior art is easy to fall off and drug saturation is few, release is too fast.The catheter includes urethral catheterization supervisor, is provided at least one groove on the urethral catheterization supervisor；The groove is formed using laser processing technology；The opening of the groove is located in urethral catheterization pipe outer wall and human contact region.The present invention also provides a kind of preparation methods of the catheter of achievable long-acting slow-release administration functions.Compared with the existing technology in the mode of urethral catheterization supervisor's outer surface coated medicament, the present invention is arranged fluted outside urethral catheterization supervisor, keep the drug being filled in groove not easily to fall off, and improve the specific surface area of urethral catheterization supervisor, and then makes urethral catheterization supervisor that can accommodate more drugs.
Description
Technical field
The present invention relates to a kind of medical instruments for urethral catheterization, and in particular to a kind of achievable long-acting slow-release administration functions
Catheter and preparation method thereof.
Background technique
Catheter is a kind of from urethra insertion bladder, the pipeline of drainage of urine, after being inserted into catheter, due to various reasons,
The generation that may cause the side effects such as hemorrhage of the urethra, infection, atrophy, especially for the patient of long-term urethral catheterization, side effect goes out
Existing probability is higher；In addition, requiring for treatment or in order to reduce the generation of side effect, need repeatedly to replace catheter, this
Greatly pain and financial burden not only are brought to patient, also increases the workload of medical worker.
In the prior art, in order to reduce or avoid the generation of side effect, there is the catheter of various antibacterials or sustained release,
It is generally utilized in the method for urethral catheterization tube outer surface coated medicament.But there is coating shedding in various degree and ask in these technologies
The problems such as topic, drug saturation are few, release is too fast.
Summary of the invention
Present invention aim to address coatings existing in the prior art to be easy to fall off, drug saturation is few, drug release
Too fast problem, and a kind of catheter and preparation method thereof of achievable long-acting slow-release administration functions is provided.
The technical solution of the invention is as follows: a kind of catheter of achievable long-acting slow-release administration functions, including urethral catheterization master
Pipe is characterized in that on the urethral catheterization supervisor and is provided at least one groove；The groove uses laser processing technology shape
At；The opening of the groove is located in urethral catheterization pipe outer wall and human contact region.
Further, the groove is provided with drug, and the drug is powder medicaments.
Further, in order to slow down the rate of release for loading drug in groove, urethral catheterization supervisor outer surface is coated with slow
Protective film is released, the sustained release protective film can be coated partially or all be coated.
Further, the sustained release protective film is protein film or Nano-meter SiO_22The film that film or both is mixed to form；
The drug is antibacterial agent, lubricant, analgestic, any one or more of mixing of anesthetic, is realized in urethral catheterization
While, reach and antibacterial is carried out to urethra, prevents urethral atrophy, conducive to insertion catheter or other treatment purpose.
Further, the width of the groove is less than 1000 microns；The groove be radial, oblique, spiral, it is netted and/
Or it is arranged circumferentially.
Based on above-mentioned catheter, the present invention also provides a kind of systems of the catheter of achievable long-acting slow-release administration functions
Preparation Method, be characterized in that the following steps are included:
Step 1 is responsible for using the preparation urethral catheterization of natural rubber, silicon rubber, polyurethane, polyvinyl chloride (PVC) or metal material；
Step 2 is responsible for external process groove in the urethral catheterization using nanosecond laser, picosecond laser or femtosecond laser, this swashs
Light when forming groove, urethral catheterization supervisor surface cannot generate because laser thermal effect cause urethral catheterization supervisor visual appearance on it is bright
Significant difference is different.
Further, the preparation method further include:
Drug is filled in the groove by step 3.
Further, after the step 3 further include:
Step 4, in step 3 gained urethral catheterization supervisor outer surface, cladding is sustained protective film.
It further, further include to weigh urethral catheterization supervisor urethral catheterization supervisor weight before and after loading drug and increase in the step 3
The content of value added method detection drug amount of fill, the step 3 specifically:
Step 3.1, the weight of urethral catheterization supervisor is weighed；
Step 3.2, by drug loaded in the groove；
Step 3.3, the weight that the urethral catheterization equipped with drug is responsible for is weighed；
Step 3.4, step 3.1 gained weight is subtracted with step 3.3 gained weight, can be detected out the amount of fill of drug.
Further, in order to improve efficiency, laser employed in the step 2 is dot laser or line laser.
The beneficial effects of the present invention are:
1. compared with the existing technology in the mode of urethral catheterization supervisor's outer surface coated medicament, the present invention is set outside urethral catheterization supervisor
It is equipped with groove, keeps the drug being filled in groove not easily to fall off, and improves the specific surface area of urethral catheterization supervisor, and then make urethral catheterization
Supervisor can accommodate more drugs；
2. the present invention forms groove using laser processing technology, laser can be applied to the catheter of various materials, and
Laser is not easy to form corrosion or mechanically deform etc. to catheter surface, and process velocity is also than very fast；
3. the groove that the present invention is constituted can also realize the slow release of encapsulated drug, reach long-acting slow-release effect；It is packed into
It can also be responsible for outer wall cladding sustained release protective film in urethral catheterization after drug, slow down the rate of release of institute's powder charge object, further reach
To long-acting slow-release effect.
Detailed description of the invention
Fig. 1 is the catheter schematic cross-section that the present invention has radial groove；
Fig. 2 is the schematic cross-section for the catheter that the present invention has annular groove.
Appended drawing reference are as follows: 1- urethral catheterization supervisor, 2- groove, 3- urethral catheterization inside pipe wall, 4- urethral catheterization pipe outer wall, 5- are sustained protective film,
6- drug.
Specific embodiment
The following describes the present invention in detail with reference to the accompanying drawings and specific embodiments.
Embodiment one: a kind of catheter of achievable long-acting slow-release administration functions as shown in Figure 1, including urethral catheterization supervisor 1,
Multiple grooves 2 are provided with outside the urethral catheterization supervisor 1；The groove 2 is formed using laser processing technology；The groove 2 is opened
Mouth is located in urethral catheterization pipe outer wall 4 and human contact region.The groove 2 is provided with drug 6, and the drug 6 is powder medicaments.Institute
It states 1 outer surface of urethral catheterization supervisor and is coated with sustained release protective film 5.The sustained release protective film 5 is protein film；The drug 6 is antibacterial agent.
The width of the groove 2 is less than 1000 microns；The groove 2 is radial, oblique, spiral or netted setting.
A kind of preparation method of the catheter of above-mentioned achievable long-acting slow-release administration functions, includes the following steps:
Step 1) is responsible for 1 using natural rubber preparation urethral catheterization；
Step 2) is responsible for 1 external process groove 2 in the urethral catheterization using dot laser, and the groove 2 is radial groove, should
When forming groove 2, being responsible for 1 surface in urethral catheterization cannot generate because laser thermal effect causes urethral catheterization to be responsible for 1 visual appearance laser
On notable difference；
Step 3), specific implementation step are as follows:
Step 3.1), the weight for weighing urethral catheterization supervisor 1；
Drug 6 is filled in the groove 2 by step 3.2) using coating method；
Step 3.3), the weight for weighing the urethral catheterization supervisor 1 equipped with drug 6；
Step 3.4), the weight obtained by step 3.3) subtract weight obtained by step 3.1), can be detected out the filling of drug 6
Amount；
Step 4) coats protein film on the outer surface for the urethral catheterization supervisor 1 for having loaded drug 6.
Embodiment two: a kind of catheter of achievable long-acting slow-release administration functions as shown in Figure 2, including urethral catheterization supervisor 1,
Multiple grooves 2 are provided with outside the urethral catheterization supervisor 1；The groove 2 is formed using laser processing technology；The groove 2 is opened
Mouth is located in urethral catheterization pipe outer wall 4 and human contact region.The groove 2 is provided with drug 6, and the drug 6 is powder medicaments.Institute
It states 1 outer surface of urethral catheterization supervisor and is coated with sustained release protective film 5.The sustained release protective film 5 is Nano-meter SiO_22Both film and protein film are mixed
Conjunction is formed by film；The drug 6 is analgestic.The width of the groove 2 is less than 1000 microns；The groove 2 sets for circumferential direction
It sets.
A kind of preparation method of the catheter of above-mentioned achievable long-acting slow-release administration functions, includes the following steps:
Step 1) is responsible for 1 using polyurethane preparation urethral catheterization；
Step 2) is responsible for 1 external process groove 2 in the urethral catheterization using line laser, and the groove 2 is circumferential groove, should
When forming groove 2, being responsible for 1 surface in urethral catheterization cannot generate because laser thermal effect causes urethral catheterization to be responsible for 1 visual appearance laser
On notable difference；
Step 3), specific implementation step are as follows:
Step 3.1), the weight for weighing urethral catheterization supervisor 1；
Drug 6 is filled in the groove 2 by step 3.2) using coating method；
Step 3.3), the weight for weighing the urethral catheterization supervisor 1 equipped with drug 6；
Step 3.4), the weight obtained by step 3.3) subtract weight obtained by step 3.1), can be detected out the filling of drug 6
Amount；
Step 4) coats Nano-meter SiO_2 on the outer surface for the urethral catheterization supervisor 1 for having loaded drug 62Both film and protein film are mixed
Conjunction is formed by film.
In a kind of catheter of achievable long-acting slow-release administration functions of the present invention and preparation method thereof, the step 2) is adopted
Many kinds of substance can be acted on, and to workpiece surface without work the advantage is that: laser has a wide range of application by forming groove 2 with laser
Firmly, it is not likely to produce mechanically deform, do not generate corrosion to material surface, and process velocity is fast.
Claims (9)
1. a kind of catheter of achievable long-acting slow-release administration functions, including urethral catheterization supervisor (1), it is characterised in that: the urethral catheterization
At least one groove (2) is provided on supervisor (1)；
The groove (2) is formed using laser processing technology；
The opening of the groove (2) is located on urethral catheterization pipe outer wall (4) and human contact region.
2. a kind of catheter of achievable long-acting slow-release administration functions according to claim 1, it is characterised in that: the groove
(2) it is provided with drug (6), the drug (6) is powder medicaments.
3. a kind of catheter of achievable long-acting slow-release administration functions according to claim 2, it is characterised in that: the urethral catheterization
Supervisor (1) outer surface is coated with sustained release protective film (5).
4. a kind of catheter of achievable long-acting slow-release administration functions according to claim 3, it is characterised in that: the sustained release
Protective film (5) is protein film, Nano-meter SiO_22Film or both mixing is formed by film；
The drug (6) is antibacterial agent, lubricant, analgestic, any one or more of mixing of anesthetic.
5. according to claim 1 to a kind of 4 any catheters of achievable long-acting slow-release administration functions, it is characterised in that:
The width of the groove (2) is less than 1000 microns；The groove (2) is radial, oblique, spiral, netted or be arranged circumferentially.
6. a kind of preparation method of the catheter of achievable long-acting slow-release administration functions, it is characterised in that: the following steps are included:
Step 1) prepares urethral catheterization supervisor (1)；
Step 2) is responsible for processing groove (2) on (1) in the urethral catheterization using laser processing technology.
7. a kind of preparation method of the catheter of achievable long-acting slow-release administration functions, feature exist according to claim 6
In: further include:
Drug (6) is filled in the groove (2) by step 3).
8. a kind of preparation method of the catheter of achievable long-acting slow-release administration functions, feature exist according to claim 7
In: after step 3) further include:
Step 4) supervisor's (1) the outer surface cladding sustained release of the urethral catheterization obtained by the step 3) protective film (5).
9. according to a kind of any preparation method of the catheter of achievable long-acting slow-release administration functions of claim 7 or 8,
It is characterized in that:
Ultrasonic delivery or negative pressure of vacuum mode is added to load drug using high-pressure injection, coating, electrophoresis, high pressure in the step 3)
(6)；
It further include to weigh urethral catheterization supervisor (1) urethral catheterization supervisor (1) weight gain before and after loading drug (6) in the step 3
Method detection drug (6) amount of fill content, the step 3 specifically:
Step 3.1, the weight of urethral catheterization supervisor (1) is weighed；
Step 3.2, by drug (6) loaded in the groove (2)；
Step 3.3, the weight of the urethral catheterization supervisor (1) equipped with drug (6) is weighed；
Step 3.4, step 3.1 gained weight is subtracted with step 3.3 gained weight, can be detected out the amount of fill of drug (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910399886.4A CN110368572A (en) | 2019-05-14 | 2019-05-14 | A kind of catheter and preparation method thereof of achievable long-acting slow-release administration functions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910399886.4A CN110368572A (en) | 2019-05-14 | 2019-05-14 | A kind of catheter and preparation method thereof of achievable long-acting slow-release administration functions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110368572A true CN110368572A (en) | 2019-10-25 |
Family
ID=68248689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910399886.4A Pending CN110368572A (en) | 2019-05-14 | 2019-05-14 | A kind of catheter and preparation method thereof of achievable long-acting slow-release administration functions |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110368572A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2664698Y (en) * | 2003-12-24 | 2004-12-22 | 陈家童 | Painless bacteria-suppressing lubricant medical catheter |
| CN200970281Y (en) * | 2006-08-28 | 2007-11-07 | 北京乐普医疗器械有限公司 | Medicine storage and medicine releasing structure for medicinal elution device |
| CN103180007A (en) * | 2010-09-09 | 2013-06-26 | W.L.戈尔及同仁股份有限公司 | Indwelling luminal devices |
| US20170246424A1 (en) * | 2014-04-23 | 2017-08-31 | Becton, Dickinson And Company | Catheter tubing with extraluminal antimicrobial coating |
| CN206560590U (en) * | 2016-11-29 | 2017-10-17 | 美昕医疗器械（上海）有限公司 | Sustained-release administration catheter |
| CN109045443A (en) * | 2018-06-21 | 2018-12-21 | 成都翼添科技有限公司 | A kind of silicone catheter having automatic sustained-release administration function |
| CN109107021A (en) * | 2018-06-22 | 2019-01-01 | 江南大学附属医院 | A kind of catheter preventing urinary tract infections |
-
2019
- 2019-05-14 CN CN201910399886.4A patent/CN110368572A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2664698Y (en) * | 2003-12-24 | 2004-12-22 | 陈家童 | Painless bacteria-suppressing lubricant medical catheter |
| CN200970281Y (en) * | 2006-08-28 | 2007-11-07 | 北京乐普医疗器械有限公司 | Medicine storage and medicine releasing structure for medicinal elution device |
| CN103180007A (en) * | 2010-09-09 | 2013-06-26 | W.L.戈尔及同仁股份有限公司 | Indwelling luminal devices |
| US20170246424A1 (en) * | 2014-04-23 | 2017-08-31 | Becton, Dickinson And Company | Catheter tubing with extraluminal antimicrobial coating |
| CN206560590U (en) * | 2016-11-29 | 2017-10-17 | 美昕医疗器械（上海）有限公司 | Sustained-release administration catheter |
| CN109045443A (en) * | 2018-06-21 | 2018-12-21 | 成都翼添科技有限公司 | A kind of silicone catheter having automatic sustained-release administration function |
| CN109107021A (en) * | 2018-06-22 | 2019-01-01 | 江南大学附属医院 | A kind of catheter preventing urinary tract infections |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5068401B2 (en) | Intestinal and colonic delivery using HPMC capsules | |
| US5762638A (en) | Anti-infective and anti-inflammatory releasing systems for medical devices | |
| CA2506997A1 (en) | Controlled drug delivery using polymer macromolecules to retard drug elution | |
| Mashak et al. | Silicone polymers in controlled drug delivery systems: a review | |
| HRP20120766T4 (en) | Colonic drug delivery formulation | |
| MXPA02007762A (en) | Timed pulsatile drug delivery systems. | |
| WO2005004945A3 (en) | Thermal treatment of a drug eluting implantable medical device | |
| IL102851A (en) | Stabilized controlled release formulations having acrylic polymer coating and their production | |
| NZ586025A (en) | Rasagiline mesylate tablet coated with a composisiton comprising methacrylic acid - ethyl acrylate copolymer and triethyl citrate | |
| ATE261721T1 (en) | SYSTEM FOR THE TARGETED DELIVERY OF ACTIVE INGREDIENTS, METHOD FOR ITS PRODUCTION AND USE | |
| CA2569542C (en) | A delivery system | |
| CN200980748Y (en) | Porous medicine releasing structure for medicine eluting apparatus | |
| CN110368572A (en) | A kind of catheter and preparation method thereof of achievable long-acting slow-release administration functions | |
| Burton et al. | Fabrication and testing of vaginal contraceptive devices designed for release of prespecified dose levels of steroids | |
| EP2335745B1 (en) | Implant with coating | |
| EP3634490A1 (en) | Implantable drug delivery device | |
| Kim et al. | Antifungal effect of a dental tissue conditioner containing nystatin-loaded alginate microparticles | |
| CN110368571A (en) | A kind of catheter and preparation method thereof that medicament slow release can be realized with laser micropore | |
| CN203790407U (en) | Nano drug carrier type self-cleaning tracheal cannula sleeve | |
| CA2997915A1 (en) | Bisacodyl compositions and delivery apparatus | |
| CN106420129B (en) | A kind of drug-carrying self-expansion type non-vascular orifice bracket conveying device | |
| EP3285836B1 (en) | Primary packaging material and method for the production of a primary packaging material | |
| CN209253923U (en) | A kind of retrograde urethrography injector | |
| CN103402495A (en) | Implant comprising a core and a tube encasing the core | |
| CN208660120U (en) | A kind of swellable polymer sponge with medicine-pouring pipe |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191025 |
|
| RJ01 | Rejection of invention patent application after publication |