CN110368571A - A kind of catheter and preparation method thereof that medicament slow release can be realized with laser micropore - Google Patents
A kind of catheter and preparation method thereof that medicament slow release can be realized with laser micropore Download PDFInfo
- Publication number
- CN110368571A CN110368571A CN201910398988.4A CN201910398988A CN110368571A CN 110368571 A CN110368571 A CN 110368571A CN 201910398988 A CN201910398988 A CN 201910398988A CN 110368571 A CN110368571 A CN 110368571A
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- China
- Prior art keywords
- micropore
- urethral catheterization
- drug
- catheter
- laser
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
- A61M25/0015—Making lateral openings in a catheter tube, e.g. holes, slits, ports, piercings of guidewire ports; Methods for processing the holes, e.g. smoothing the edges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/006—Catheters; Hollow probes characterised by structural features having a special surface topography or special surface properties, e.g. roughened or knurled surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0496—Urine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1078—Urinary tract
- A61M2210/1085—Bladder
Abstract
The present invention relates to a kind of medical instruments for urethral catheterization, and in particular to a kind of catheter and preparation method thereof that medicament slow release can be realized with laser micropore.To solve the problems such as medication coat existing in the prior art is easy to fall off, drug saturation is few, drug release is too fast.At least one micropore is provided on the urethral catheterization supervisor；The micropore is formed using laser processing technology；The micropore is that both ends aperture is respectively positioned on the through-hole of urethral catheterization pipe outer wall or one end aperture is located at the blind hole of urethral catheterization pipe outer wall.The micropore is set to urethral catheterization and is responsible for upper and human contact region.The present invention also provides a kind of preparation methods of above-mentioned catheter.Compared with the existing technology in the mode of urethral catheterization supervisor's outer surface coated medicament, micropore is arranged on urethral catheterization supervisor in the present invention, not only make the drug being filled in micropore not easily to fall off, and improve the specific surface area of urethral catheterization supervisor and accommodate performance, improve the total amount for being packed into treatment or/and prevention purpose drug.
Description
Technical field
The present invention relates to a kind of medical instruments for urethral catheterization, and in particular to there is one kind laser micropore can realize that drug is slow
Catheter released and preparation method thereof.
Background technique
Catheter is a kind of from urethra insertion bladder, the pipeline of drainage of urine, after being inserted into catheter, due to various reasons,
The generation that may cause the side effects such as hemorrhage of the urethra, infection, atrophy, especially for the patient of long-term urethral catheterization, side effect goes out
Existing probability is higher；In addition, requiring for treatment or in order to reduce the generation of side effect, catheter is needed to frequently replace, this
Greatly pain and financial burden not only are brought to patient, also increases the workload of medical worker.
In the prior art, in order to reduce or avoid the generation of side effect, there is the catheter of various antibacterials or sustained release,
It is generally utilized in the method for urethral catheterization tube outer surface coated medicament.But these technology and methods are different degrees of, and there is paintings
The problems such as layer problem easy to fall off and drug saturation are few, release is too fast.
Summary of the invention
That present invention aim to address medication coats existing in the prior art is easy to fall off, drug saturation is few, drug is released
It puts the problems such as too fast, and a kind of catheter and preparation method thereof that can realize medicament slow release with laser micropore is provided.
The technical scheme adopted by the invention is that a kind of catheter that medicament slow release can be realized with laser micropore, including
Urethral catheterization supervisor is characterized in that on the urethral catheterization supervisor and is provided at least one micropore；The micropore is using laser processing
Technique is formed；The micropore is that both ends aperture is respectively positioned on the through-hole of urethral catheterization pipe outer wall or one end aperture is located at the blind of urethral catheterization pipe outer wall
Hole.
The micropore is set to urethral catheterization and is responsible for upper and human contact region.
Further, the micropore is provided with drug, and the drug is drug solution, liquid medicine or gel-like drug.
Further, in order to slow down the rate of release of drug in micropore, urethral catheterization supervisor outer surface is coated with sustained release and protects
Cuticula, the sustained release protective film can be coated partially or all be coated.
Further, the sustained release protective film is protein film, Nano-meter SiO_22The film that film or both is mixed to form；The drug
For antibacterial agent, lubricant, analgestic, any one or more of mixing of anesthetic, realizes while urethral catheterization, reach to urethra
Antibacterial is carried out, urethral atrophy is prevented, is conducive to insertion catheter or other treatment purpose.
Further, the aperture of the micropore is less than 1000 microns；The micropore is using axial, oblique, circumferential or netted
Arrangement.
Based on above-mentioned catheter, the present invention also provides a kind of catheters that medicament slow release can be realized with laser micropore
Preparation method, be characterized in that the following steps are included:
Step 1 is responsible for using the preparation urethral catheterization of natural rubber, silicon rubber, polyurethane, polyvinyl chloride (PVC) or metal material；
Step 2 processes micropore on urethral catheterization supervisor surface using nanosecond laser, picosecond laser or femtosecond laser, should
Laser cannot be generated on urethral catheterization supervisor surface when forming micropore because laser thermal effect causes in urethral catheterization supervisor's visual appearance
Notable difference.
Further, the preparation method further include:
Drug solution or liquid medicine or gel-like drug are loaded in the micropore, then lead to equipped with drug by step 3
The outer surface of urine supervisor is dried.
Further, after the step 3 further include:
Step 4, in step 3 gained urethral catheterization supervisor outer surface, cladding is sustained protective film.
Further, drug is loaded in the micropore in the step 3, is using high-pressure injection, coating, electrophoresis, height
Pressure plus ultrasonic delivery or negative pressure of vacuum mode are packed into drug；
It further include the method to weigh urethral catheterization supervisor urethral catheterization supervisor weight gain before and after loading drug in the step 3
Detect the content of drug amount of fill, the step 3 specifically:
Step 3.1, the weight of urethral catheterization supervisor is weighed；
Step 3.2, by drug loaded in the micropore；
Step 3.3, the urethral catheterization supervisor outer surface equipped with drug is dried；
Step 3.4, the weight that the urethral catheterization equipped with drug is responsible for is weighed；
Step 3.5, step 3.1 gained weight is subtracted with step 3.4 gained weight, can be detected out the amount of fill of drug.
Further, in order to improve efficiency, laser employed in the step 2 is specially dot laser or line laser.
After capillary processing is complete in the step 2, urethral catheterization tube outer surface is cleaned using certain way, cleaning mode is washed for acid solution
And/or lye is washed and/or washed and/or alcohol is washed or/and surfactant is washed or/and ultrasonic cleaning etc., is beaten with removing laser
The particle generated during hole.
The beneficial effects of the present invention are:
1. compared with the existing technology in the mode of urethral catheterization supervisor's outer surface coated medicament, the present invention is responsible for outer setting in urethral catheterization
Micropore not only makes the drug being filled in micropore not easily to fall off, but also improves the specific surface area of urethral catheterization supervisor and accommodate performance,
Improve the total amount for being packed into treatment or/and prevention purpose drug；
2. the present invention forms micropore using laser processing technology, laser can be applied to the catheter of various materials, and
Laser is not easy to form corrosion or mechanically deform etc. to catheter surface, and process velocity is also than very fast；
3. the micropore that the present invention constitutes microstructure can also realize the slow release of encapsulated drug, reach long-acting slow-release work
With；Outer wall cladding sustained release protective film can also be responsible in urethral catheterization later by being packed into drug, slow down the rate of release of institute's powder charge object, into
One step reaches long-acting slow-release effect.
Detailed description of the invention
Fig. 1 is the catheter sectional view that the present invention has vertical micropore；
Fig. 2 is the catheter sectional view that the present invention has circumferential micropore.
Appended drawing reference are as follows: 1- urethral catheterization supervisor, 2- micropore, 3- urethral catheterization inside pipe wall, 4- urethral catheterization pipe outer wall, 5- are sustained protective film,
6- drug.
Specific embodiment
The following describes the present invention in detail with reference to the accompanying drawings and specific embodiments.
Embodiment one: a kind of catheter that medicament slow release can be realized with laser micropore as shown in Figure 1, including urethral catheterization master
Pipe 1, the urethral catheterization supervisor can be single-chamber catheter, double lumen catheter or three-cavity catheter etc., and the urethral catheterization is responsible on 1 outside
It is provided with multiple micropores 2；The micropore 2 is formed using dot laser processing technology；The micropore 2 is that one end aperture is located at catheter
The blind hole of outer wall 4, the micropore 2 are set on urethral catheterization supervisor 1 and human contact region.The micropore 2 is provided with drug 6, institute
Stating drug 6 is drug solution.The outer surface of the urethral catheterization supervisor 1 is coated with sustained release protective film 5.The sustained release protective film 5 is egg
Tunica albuginea；The drug 6 is lubricant.The aperture of the micropore 2 is less than 1000 microns；The micropore 2 uses axial, oblique, ring
To or meshy arrangement.
A kind of above-mentioned urethral catheterization tube preparation method that medicament slow release can be realized with laser micropore, includes the following steps:
Step 1) is responsible for 1 using silicon rubber preparation urethral catheterization；
Step 2) processes micropore 2 using dot laser on the outer surface of the urethral catheterization supervisor 1, and the micropore 2 is one end
Aperture is located at the blind hole of urethral catheterization pipe outer wall 4, and when forming micropore 2, being responsible for 1 surface in urethral catheterization cannot generate because of laser the laser
Fuel factor causes urethral catheterization to be responsible for the notable difference in 1 visual appearance；
Step 3), specific implementation step are as follows:
Step 3.1), the weight for weighing urethral catheterization supervisor 1；
Drug 6 is loaded in the micropore 2 by step 3.2) using high-pressure injection mode；
1 outer surface of urethral catheterization supervisor equipped with drug 6 is dried in step 3.3)；
Step 3.4), the weight for weighing the urethral catheterization supervisor 1 equipped with drug 6；
Step 3.5), the weight obtained by step 3.4) subtract weight obtained by step 3.1), can be detected out the filling of drug 6
Amount.
Step 4) coats protein film on the outer surface for the urethral catheterization supervisor 1 for installing drug 6.
Embodiment two:
A kind of catheter that medicament slow release can be realized with laser micropore as shown in Figure 2, including urethral catheterization supervisor 1, it is described
Urethral catheterization supervisor can be single-chamber catheter or double lumen catheter or three-cavity catheter etc., and the urethral catheterization is responsible on 1 outside and is provided with
Multiple micropores 2；The micropore 2 is formed using line laser processing technology；The micropore 2 is that both ends aperture is respectively positioned on urethral catheterization pipe outer wall
4 through-hole.The micropore 2 is set on urethral catheterization supervisor 1 and human contact region.The micropore 2 is provided with drug 6, the medicine
Object 6 is liquid medicine.The outer surface of the urethral catheterization supervisor 1 is coated with sustained release protective film 5.The sustained release protective film 5 is nanometer
SiO2Film；The drug 6 is anesthetic.The aperture of the micropore 2 is less than 1000 microns；The micropore 2 using it is axial, oblique,
Circumferential or meshy arrangement.
A kind of above-mentioned urethral catheterization tube preparation method that medicament slow release can be realized with laser micropore, includes the following steps:
Step 1) is responsible for 1 using polyvinyl chloride preparation urethral catheterization；
Step 2) processes micropore 2 using line laser on the outer surface of the urethral catheterization supervisor 1, and the micropore 2 is both ends
Aperture is respectively positioned on the through-hole of urethral catheterization pipe outer wall, and when forming micropore 2, being responsible for 1 surface in urethral catheterization cannot generate because swashing the laser
Photo-thermal effect causes urethral catheterization to be responsible for the notable difference in 1 visual appearance；
Step 3), specific implementation step are as follows:
Step 3.1), the weight for weighing urethral catheterization supervisor 1；
Drug 6 is loaded in the micropore 2 by step 3.2) using electrophoretic；
1 outer surface of urethral catheterization supervisor equipped with drug 6 is dried in step 3.3)；
Step 3.4), the weight for weighing the urethral catheterization supervisor 1 equipped with drug 6；
Step 3.5), the weight obtained by step 3.4) subtract weight obtained by step 3.1), can be detected out the filling of drug 6
Amount.
Step 4) coats Nano-meter SiO_2 on the outer surface for the urethral catheterization supervisor 1 for installing drug 62Film.
In a kind of catheter that can realize medicament slow release with laser micropore of the present invention and preparation method thereof, the step
2) many kinds of substance can be acted on, and to workpiece surface the advantage is that: laser has a wide range of application by forming micropore 2 using laser
No active force is not likely to produce mechanically deform, does not generate corrosion to material surface, and process velocity is fast.
Claims (9)
1. a kind of catheter that can realize medicament slow release with laser micropore, including urethral catheterization supervisor (1), it is characterised in that: described
At least one micropore (2) is provided on urethral catheterization supervisor (1)；
The micropore (2) is formed using laser processing technology；
The micropore (2) is that both ends aperture is respectively positioned on the through-hole of urethral catheterization pipe outer wall (4) or one end aperture is located at urethral catheterization pipe outer wall
Blind hole；
The micropore (2) is set on urethral catheterization supervisor (1) and human contact region.
2. a kind of catheter that can realize medicament slow release with laser micropore according to claim 1, it is characterised in that: described
Micropore (2) is provided with drug (6), and the drug (6) is drug solution, liquid medicine or gel-like drug.
3. a kind of catheter that can realize medicament slow release with laser micropore according to claim 2, it is characterised in that: described
The outer surface of urethral catheterization supervisor (1) is coated with sustained release protective film (5).
4. a kind of catheter that can realize medicament slow release with laser micropore according to claim 3, it is characterised in that: described
Being sustained protective film (5) is protein film or Nano-meter SiO_22The film that film or both is mixed to form；
The drug (6) is antibacterial agent, lubricant, analgestic, any one or more of mixing of anesthetic.
5. according to claim 1 to a kind of 4 any catheters that can realize medicament slow release with laser micropore, feature exists
In: the aperture of the micropore (2) is less than 1000 microns；The micropore (2) uses axial, oblique, circumferential or meshy arrangement.
6. a kind of preparation method for the catheter that can realize medicament slow release with laser micropore, which is characterized in that including following step
It is rapid:
Step 1, preparation urethral catheterization supervisor (1)；
Step 2, outer surface processing micropore (2) for being responsible for (1) in the urethral catheterization using laser.
7. a kind of preparation method for the catheter that can realize medicament slow release with laser micropore according to claim 6, special
Sign is: further include:
Drug (6) are loaded in the micropore (2) by step 3, then are carried out to the outer surface of the urethral catheterization supervisor (1) equipped with drug (6)
It is dry.
8. a kind of preparation method for the catheter that can realize medicament slow release with laser micropore according to claim 7, special
Sign is, after step 3 further include:
Step 4, in step 3 gained urethral catheterization supervisor (1) outer surface, cladding is sustained protective film (5).
9. according to a kind of any preparation side for the catheter that can realize medicament slow release with laser micropore of claim 7 or 8
Method, it is characterised in that:
Drug (6) are loaded in the micropore (2) in the step 3, are that ultrasound is added using high-pressure injection, coating, electrophoresis, high pressure
Waveguide enters or negative pressure of vacuum mode is packed into drug (6)；
It further include to weigh urethral catheterization supervisor (1) urethral catheterization supervisor (1) weight gain before and after loading drug (6) in the step 3
Method detection drug (6) amount of fill content, the step 3 specifically:
Step 3.1, the weight of urethral catheterization supervisor (1) is weighed；
Step 3.2, by drug (6) loaded in the micropore (2)；
Step 3.3, urethral catheterization supervisor (1) outer surface equipped with drug (6) is dried；
Step 3.4, the weight of the urethral catheterization supervisor (1) equipped with drug (6) is weighed；
Step 3.5, step 3.1 gained weight is subtracted with step 3.4 gained weight, can be detected out the amount of fill of drug (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910398988.4A CN110368571A (en) | 2019-05-14 | 2019-05-14 | A kind of catheter and preparation method thereof that medicament slow release can be realized with laser micropore |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910398988.4A CN110368571A (en) | 2019-05-14 | 2019-05-14 | A kind of catheter and preparation method thereof that medicament slow release can be realized with laser micropore |
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|---|---|
| CN110368571A true CN110368571A (en) | 2019-10-25 |
Family
ID=68248531
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|---|---|---|---|
| CN201910398988.4A Pending CN110368571A (en) | 2019-05-14 | 2019-05-14 | A kind of catheter and preparation method thereof that medicament slow release can be realized with laser micropore |
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Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008076931A2 (en) * | 2006-12-15 | 2008-06-26 | Boston Scientific Limited | Medical device including structure for crossing an occlusion in a vessel |
| CN103180007A (en) * | 2010-09-09 | 2013-06-26 | W.L.戈尔及同仁股份有限公司 | Indwelling luminal devices |
| US20130310825A1 (en) * | 2007-04-04 | 2013-11-21 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Irrigated catheter with improved fluid flow |
| CN203763136U (en) * | 2013-09-26 | 2014-08-13 | 李峨 | Medical silicone tube |
| CN104602742A (en) * | 2012-07-17 | 2015-05-06 | 爱尔康研究有限公司 | Soft tip cannula |
| JP2017042230A (en) * | 2015-08-24 | 2017-03-02 | 信越ポリマー株式会社 | tube |
| US20170246424A1 (en) * | 2014-04-23 | 2017-08-31 | Becton, Dickinson And Company | Catheter tubing with extraluminal antimicrobial coating |
| CN206560590U (en) * | 2016-11-29 | 2017-10-17 | 美昕医疗器械（上海）有限公司 | Sustained-release administration catheter |
| CN208243829U (en) * | 2017-08-01 | 2018-12-18 | 象山县第一人民医院 | A kind of catheter |
| CN109045443A (en) * | 2018-06-21 | 2018-12-21 | 成都翼添科技有限公司 | A kind of silicone catheter having automatic sustained-release administration function |
| CN109107021A (en) * | 2018-06-22 | 2019-01-01 | 江南大学附属医院 | A kind of catheter preventing urinary tract infections |
-
2019
- 2019-05-14 CN CN201910398988.4A patent/CN110368571A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008076931A2 (en) * | 2006-12-15 | 2008-06-26 | Boston Scientific Limited | Medical device including structure for crossing an occlusion in a vessel |
| US20130310825A1 (en) * | 2007-04-04 | 2013-11-21 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Irrigated catheter with improved fluid flow |
| CN103180007A (en) * | 2010-09-09 | 2013-06-26 | W.L.戈尔及同仁股份有限公司 | Indwelling luminal devices |
| CN104602742A (en) * | 2012-07-17 | 2015-05-06 | 爱尔康研究有限公司 | Soft tip cannula |
| CN203763136U (en) * | 2013-09-26 | 2014-08-13 | 李峨 | Medical silicone tube |
| US20170246424A1 (en) * | 2014-04-23 | 2017-08-31 | Becton, Dickinson And Company | Catheter tubing with extraluminal antimicrobial coating |
| JP2017042230A (en) * | 2015-08-24 | 2017-03-02 | 信越ポリマー株式会社 | tube |
| CN206560590U (en) * | 2016-11-29 | 2017-10-17 | 美昕医疗器械（上海）有限公司 | Sustained-release administration catheter |
| CN208243829U (en) * | 2017-08-01 | 2018-12-18 | 象山县第一人民医院 | A kind of catheter |
| CN109045443A (en) * | 2018-06-21 | 2018-12-21 | 成都翼添科技有限公司 | A kind of silicone catheter having automatic sustained-release administration function |
| CN109107021A (en) * | 2018-06-22 | 2019-01-01 | 江南大学附属医院 | A kind of catheter preventing urinary tract infections |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20191025 |