CN110354249A - A kind of hepatoprotective composition and preparation method thereof - Google Patents
A kind of hepatoprotective composition and preparation method thereof Download PDFInfo
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention belongs to the field of Chinese medicines, disclose a kind of hepatoprotective composition, according to parts by weight, including following components: 80-350 parts of phosphatide, 10-50 parts of glutathione, 15-50 parts of grape seed extract, 1-10 parts of vitamin, 1-9 parts of glycine betaine.The invention also discloses the preparation methods of the hepatoprotective composition.The liver protective effect of hepatoprotective composition of the present invention is good, takes for a long time also without side-effects.In addition, the hepatoprotective composition can be used for the antidote of alcohol acute poisoning.
Description
Technical field
The invention belongs to the field of Chinese medicines, in particular to a kind of hepatoprotective composition and preparation method thereof.
Background technique
Hepatopathy refers to the lesion occurred in liver region.Common hepatopathy has hepatitis B, hepatitis A, hepatitis, cirrhosis, fat
Change, alcoholic liver etc..
Wherein, alcoholic liver disease is the liver diseases as caused by long-term heavy drinking.Initial stage is usually expressed as fatty liver,
And then alcoholic hepatitis, liver fibrosis and cirrhosis can be developed into.Its main clinical characteristics is Nausea and vomiting, jaundice, can have liver
Dirty enlargement and tenderness.And it can concurrent liver failure and upper gastrointestinal bleeding etc..
In the prior art, alcoholic hepatitis is treated using Western medicine, such as steroid chemical drug, effect is although good, but
It is that side effect is big, is especially unsuitable for being used for a long time.The prior art is poor using Chinese medicine treatment alcoholic hepatitis effect, treatment cycle
It is general longer.
Therefore it provides a kind of effect is good, and hepatoprotective composition without side-effects very it is necessary to.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of hepatoprotective composition and preparation method thereof.The present invention is prepared into
To hepatoprotective composition have good protecting effect to liver, especially to hepatitis caused by alcohol.When hepatitis symptom is unobvious
When, also edible hepatoprotective composition of the present invention, can play the role of preventing liver diseases.
A kind of hepatoprotective composition, according to parts by weight, including following components:
Preferably, a kind of hepatoprotective composition, according to parts by weight, including following components:
Preferably, the phosphatide is soybean lecithin.
Preferably, the vitamin is selected from least one of vitamin B, vitamin C and vitamin E.
It is further preferred that the vitamin B is at least two in vitamin B1, Vitamin B9 and vitamin B12.
Preferably, the grape seed extract extracts grape pip with ethanol solution, extracts 2-3 times, the temperature of extraction
Degree is 85-100 DEG C, and the time of extraction is 1.5-2.5 hours, then filters, takes filtrate, with ethanol elution, collects eluent, then
Be dried at 95-195 DEG C (the dry time is very short, can be several seconds kinds, it is preferred that the drying be spray drying, spray
The dry inlet air temperature of mist is 150-195 DEG C, 95-105 DEG C of leaving air temp), sieve is finally crossed, the mesh number of sieve is 80-100
Mesh obtains the grape seed extract.
A kind of preparation method of hepatoprotective composition, comprising the following steps:
(1) each component is weighed by formula ratio, glutathione and grape seed extract is stirred, mixture A is made, it is standby
With；
(2) phosphatide and vitamins are stirred, mixture B is made, it is spare；
(3) mixture A, mixture B and glycine betaine are stirred, the speed of stirring is 200-300 revs/min, stirring
Time be 20-40 minutes, obtain the hepatoprotective composition.
Preferably, the temperature being stirred in step (1) is 60-80 DEG C.
Preferably, the temperature being stirred in step (2) is 10-35 DEG C.
Preferably, the temperature being stirred in step (3) is 20-40 DEG C.
It preferably, further include packing, packaging step after step (3) (packing, packaging step are routine techniques).
Phosphatide, glutathione in hepatoprotective composition of the present invention, grape seed extract three exists simultaneously significantly to mention
The liver protective effect of high composition.The addition of glycine betaine facilitates the liver protective effect for further improving composition.
Hepatoprotective composition of the present invention can be used for the antidote of alcohol acute poisoning.
Compared with the existing technology, beneficial effects of the present invention are as follows:
(1) liver protective effect of hepatoprotective composition of the present invention is good, takes for a long time also without side-effects.
(2) preparation method of hepatoprotective composition of the present invention is simple, is suitble to industrial volume production.
Specific embodiment
In order to allow those skilled in the art that technical solution of the present invention is more clearly understood, now enumerate following embodiment into
Row explanation.It should be pointed out that following embodiment to the present invention claims protection scope do not constitute a limitation effect.
Embodiment 1
A kind of hepatoprotective composition, according to parts by weight, including following components:
The vitamin is 1 part of vitamin B, 1 part of vitamin C.
The vitamin B is Vitamin B9 and vitamin B12.
The grape seed extract extracts grape pip with ethanol solution, extracts 2 times, and the temperature of extraction is 85 DEG C,
The time of extraction is 2 hours, then filters, takes filtrate, with ethanol elution, collects eluent, then be dried, the drying is
Spray drying, the inlet air temperature of spray drying are 150-195 DEG C, 95-105 DEG C of leaving air temp, finally cross sieve, the mesh number of sieve
For 80 mesh, the grape seed extract is obtained.
A kind of preparation method of hepatoprotective composition, comprising the following steps:
(1) each component is weighed by formula ratio, glutathione and grape seed extract is stirred, mixture A is made, it is standby
With；
(2) phosphatide and vitamins are stirred, mixture B is made, it is spare；
(3) mixture A, mixture B and glycine betaine are stirred, the speed of stirring is 200 revs/min, stirring when
Between be 40 minutes, obtain the hepatoprotective composition.
The temperature being stirred in step (1) is 70 DEG C.
The temperature being stirred in step (2) is 15 DEG C.
The temperature being stirred in step (3) is 30 DEG C.
Embodiment 2
A kind of hepatoprotective composition, according to parts by weight, including following components:
The phosphatide is soybean lecithin.
The vitamin is vitamin B and vitamin C.
The vitamin B is 2 parts of vitamin B1,2 parts of Vitamin B9 and 1 part of vitamin B12.
The grape seed extract extracts grape pip with ethanol solution, extracts 2 times, and the temperature of extraction is 90 DEG C,
The time of extraction is 2 hours, then filters, takes filtrate, with ethanol elution, collects eluent, then be dried, the drying is
Spray drying, the inlet air temperature of spray drying are 150-195 DEG C, 95-105 DEG C of leaving air temp, finally cross sieve, the mesh number of sieve
For 90 mesh, the grape seed extract is obtained.
A kind of preparation method of hepatoprotective composition, comprising the following steps:
(1) each component is weighed by formula ratio, glutathione and grape seed extract is stirred, mixture A is made, it is standby
With；
(2) phosphatide and vitamins are stirred, mixture B is made, it is spare；
(3) mixture A, mixture B and glycine betaine are stirred, the speed of stirring is 250 revs/min, stirring when
Between be 30 minutes, obtain the hepatoprotective composition.
The temperature being stirred in step (1) is 60 DEG C.
The temperature being stirred in step (2) is 20 DEG C.
The temperature being stirred in step (3) is 30 DEG C.
It further include packing, packaging step after step (3) (packing, packaging step are routine techniques).
Embodiment 3
A kind of hepatoprotective composition, according to parts by weight, including following components:
The phosphatide is soybean lecithin.
The vitamin is vitamin E.
The grape seed extract extracts grape pip with ethanol solution, extracts 3 times, and the temperature of extraction is 100 DEG C,
The time of extraction is 1.5 hours, then filters, takes filtrate, with ethanol elution, collects eluent, then done at 160 DEG C
It is dry, sieve is finally crossed, the mesh number of sieve is 80 mesh, obtains the grape seed extract.
A kind of preparation method of hepatoprotective composition, comprising the following steps:
(1) each component is weighed by formula ratio, glutathione and grape seed extract is stirred, mixture A is made, it is standby
With；
(2) phosphatide and vitamins are stirred, mixture B is made, it is spare；
(3) mixture A, mixture B and glycine betaine are stirred, the speed of stirring is 300 revs/min, stirring when
Between be 35 minutes, obtain the hepatoprotective composition.
The temperature being stirred in step (1) is 70 DEG C.
The temperature being stirred in step (2) is 25 DEG C.
The temperature being stirred in step (3) is 32 DEG C.
Comparative example 1
Compared with Example 2, grape seed extract, remaining preparation side are not contained in the hepatoprotective composition that prepared by comparative example 1
Method is identical with process.
Comparative example 2
Compared with Example 2, glutathione, remaining preparation method and mistake are free of in the hepatoprotective composition that prepared by comparative example 1
Cheng Xiangtong.
Product measure of merit
Experimental animal: SPF grades of male Kunming strain mices, 18-22g, are mentioned by Hubei Province Animal Experimental Study center by 60
For experimental animal production licence number is SCXK (Hubei Province) 2015-0018, and experimental animal is SYXK (Hubei Province) using credit number
2017-0065, experimental animal feed are provided by the multifarious Jia Xing Biotechnology Co., Ltd in Wuhan, the license of experimental animal Feed Manufacturing
Card number is SYXK (Hubei Province) 2016-0011.Animal feeding room temperature is 20-26 DEG C, humidity 40-70%.
Adult (60kg) the daily intaking amount recommendation of hepatoprotective composition of the present invention is 2.95g, i.e., 0.049g/kg/ days.It takes
For hepatoprotective composition prepared by embodiment 2 to Mouse oral, day dose is recommended amounts 0.98g/kg/ days, as normal usage
20 times, it is configured to the aqueous solution of 100mL when oral, continuously takes 30 days, and at the 30th day, once gives intragastric administration on mice 50%
(volume fraction) ethyl alcohol 14mL/kg (i.e. if mouse is 1kg weight, stomach-filling 50% (volume fraction) ethyl alcohol 14mL).
In addition blank control group is set, i.e., gives the water of Mouse oral 100mL daily, continuously takes 30 days.A model group is set again, i.e., gives daily
The water of Mouse oral 100mL once gives intragastric administration on mice 50% ethyl alcohol 14mL/kg when continuously taking 30 days, the 30th day.Then fasting
16 hours, rear cervical dislocation put to death the mouse of three groups, carried out malonaldehyde, reduced form paddy Guang after taking 0.5g liver to prepare liver homogenate
Sweet peptide, three indexs of triglycerides measurement (malonaldehyde, triglycerides numerical value are relatively low, and reduced glutathione numerical value is higher,
The protect liver that has then shown, liver protective effect), the results are shown in Table 1 (three indexs counted in table are average value).
Table 1:
As it can be seen from table 1 (not taking second relative to blank control group after mouse takes ethyl alcohol 14mL/kg in model group
Alcohol), the malonaldehyde, content of triglyceride in model group mouse liver are obviously higher, and reduced glutathione content is obviously relatively low,
But mouse takes the hepatoprotective composition of the preparation of embodiment 2, even if mouse takes ethyl alcohol 14mL/kg again, in mouse liver the third two
Aldehyde, triglycerides, reduced glutathione content are all close to normal value, i.e., close to the value of blank control group.It can be seen that this hair
The hepatoprotective composition of bright preparation has liver protection, liver tonifying and protecting effects really.Especially for primary a large amount of ethanol injections, still there is liver protection
Protect liver effect.In addition take embodiment 2 preparation hepatoprotective composition, continuous 30 days, and the amount of daily intaking be normal usage 20
Times, mouse still will not be dead, even if hepatoprotective composition that is, prepared by the present invention is taken for a long time, there will not be side effect.
The hepatoprotective composition prepared respectively with comparative example 1 and comparative example 2, according to 2 groups of identical conditions of above-described embodiment into
Row test, then detects malonaldehyde, the content of reduced glutathione, triglycerides, the results are shown in Table 2.
Table 2:
It can be seen that the liver protective effect of hepatoprotective composition prepared by comparative example 1-2 relative to implementation from Tables 1 and 2 data
The liver protective effect of hepatoprotective composition prepared by example 2 wants poor.
Claims (10)
1. a kind of hepatoprotective composition, which is characterized in that according to parts by weight, including following components:
2. hepatoprotective composition according to claim 1, which is characterized in that the phosphatide is soybean lecithin.
3. hepatoprotective composition according to claim 1, which is characterized in that the vitamin is selected from vitamin B, vitamin C
At least one of with vitamin E.
4. hepatoprotective composition according to claim 3, which is characterized in that the vitamin B is vitamin B1, Vitamin B9
With at least two in vitamin B12.
5. hepatoprotective composition according to claim 1, which is characterized in that the grape seed extract is with ethyl alcohol to grape
Seed extracts, and then filters, and takes filtrate, with ethanol elution, collects eluent, then be dried, and finally crosses sieve, obtains
The grape seed extract.
6. hepatoprotective composition according to claim 5, which is characterized in that the temperature of extraction be 85-100 DEG C, extraction when
Between be 1.5-2.5 hours.
7. a kind of preparation method of hepatoprotective composition of any of claims 1-6, which is characterized in that including following step
It is rapid:
(1) each component is weighed by formula ratio, glutathione and grape seed extract is stirred, mixture A is made, it is spare；
(2) phosphatide and vitamins are stirred, mixture B is made, it is spare；
(3) mixture A, mixture B and glycine betaine are stirred, the hepatoprotective composition is made.
8. preparation method according to claim 7, which is characterized in that the temperature being stirred in step (1) is 60-80
℃；The temperature being stirred in step (2) is 10-35 DEG C；The temperature being stirred in step (3) is 20-40 DEG C.
9. preparation method according to claim 7, which is characterized in that stirred during being stirred in step (3)
Speed is 200-300 revs/min, and the time of stirring is 20-40 minutes.
10. a kind of antidote of alcoholism, which is characterized in that the antidote includes described in any one of claim 1-6
Hepatoprotective composition.
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| CN201910683580.1A CN110354249A (en) | 2019-07-26 | 2019-07-26 | A kind of hepatoprotective composition and preparation method thereof |
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| CN201910683580.1A CN110354249A (en) | 2019-07-26 | 2019-07-26 | A kind of hepatoprotective composition and preparation method thereof |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706416A (en) * | 2004-06-08 | 2005-12-14 | 丁先风 | Biological and pharmacological effects and prepn process of liver protecting prepn containing vitamins |
| CN103908532A (en) * | 2013-01-08 | 2014-07-09 | 天津天狮生物发展有限公司 | Anti-oxidation traditional Chinese medicine composition, preparation method and application |
| CN104068397A (en) * | 2014-06-12 | 2014-10-01 | 浙江海力生生物科技有限公司 | Soft capsule health food capable of protecting liver and preparation method of food |
| CN104306370A (en) * | 2014-09-28 | 2015-01-28 | 株洲千金药业股份有限公司 | Medicine composition for treatment of liver protection and preparation method of medicine composition |
| CN105902998A (en) * | 2016-06-15 | 2016-08-31 | 雷娟 | Liver protecting capsules |
| CN106214773A (en) * | 2016-07-29 | 2016-12-14 | 神威药业集团有限公司 | A kind of to chemical liver injury compositions having assistant protection function and preparation method thereof |
| CN108576819A (en) * | 2018-04-24 | 2018-09-28 | 北京中和鸿业医药科技有限公司 | A kind of liver-protecting combination, health food, preparation method and applications |
| CN108686199A (en) * | 2017-04-05 | 2018-10-23 | 石药集团中诺药业（泰州）有限公司 | A kind of liver protecting composition |
-
2019
- 2019-07-26 CN CN201910683580.1A patent/CN110354249A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706416A (en) * | 2004-06-08 | 2005-12-14 | 丁先风 | Biological and pharmacological effects and prepn process of liver protecting prepn containing vitamins |
| CN103908532A (en) * | 2013-01-08 | 2014-07-09 | 天津天狮生物发展有限公司 | Anti-oxidation traditional Chinese medicine composition, preparation method and application |
| CN104068397A (en) * | 2014-06-12 | 2014-10-01 | 浙江海力生生物科技有限公司 | Soft capsule health food capable of protecting liver and preparation method of food |
| CN104306370A (en) * | 2014-09-28 | 2015-01-28 | 株洲千金药业股份有限公司 | Medicine composition for treatment of liver protection and preparation method of medicine composition |
| CN105902998A (en) * | 2016-06-15 | 2016-08-31 | 雷娟 | Liver protecting capsules |
| CN106214773A (en) * | 2016-07-29 | 2016-12-14 | 神威药业集团有限公司 | A kind of to chemical liver injury compositions having assistant protection function and preparation method thereof |
| CN108686199A (en) * | 2017-04-05 | 2018-10-23 | 石药集团中诺药业（泰州）有限公司 | A kind of liver protecting composition |
| CN108576819A (en) * | 2018-04-24 | 2018-09-28 | 北京中和鸿业医药科技有限公司 | A kind of liver-protecting combination, health food, preparation method and applications |
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