CN110354049A - A kind of Hair-loss-preventingshampoo shampoo and preparation method thereof - Google Patents
A kind of Hair-loss-preventingshampoo shampoo and preparation method thereof Download PDFInfo
- Publication number
- CN110354049A CN110354049A CN201910825548.2A CN201910825548A CN110354049A CN 110354049 A CN110354049 A CN 110354049A CN 201910825548 A CN201910825548 A CN 201910825548A CN 110354049 A CN110354049 A CN 110354049A
- Authority
- CN
- China
- Prior art keywords
- hair
- parts
- loss
- added
- glycoprotein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The present invention provides a kind of Hair-loss-preventingshampoo shampoos, belong to dressing preparation field.Hair-loss-preventingshampoo shampoo provided by the invention includes at least cationization Plant glycoprotein, any one of the Plant glycoprotein in arabidopsis leaf glycoprotein, tealeaves glycoprotein, perilla leaf glycoprotein or pumpkin glycoprotein.Above-mentioned Hair-loss-preventingshampoo shampoo can also include the Anti-hair loss factor, its stability in shampoo is increased by way of metal-chelating.Vegetable oil albumen Hair-loss-preventingshampoo shampoo obtained has good Anti-hair loss function and foamability after containing cationization Plant glycoprotein and on the basis of the Anti-hair loss factor, adding auxiliary agent appropriate.
Description
Technical field
The invention belongs to dressing preparation field, especially a kind of Hair-loss-preventingshampoo shampoo.
Background technique
Alopecia refers to the phenomenon that epilation.The hair normally to fall off is at the hair of catagen and stand-down, by
It is constantly in dynamic equilibrium in entering catagen and newly entering the hair in growth period, therefore the hair of normal quantity can be maintained.Pathology
Property alopecia refer to that hair is abnormal or excessive and fall off that there are many reason.
Main cause includes following several:
1. nervous baldness
Usually occur alopecia when stress is excessive to increase.Under the action of stress, the contraction of human body arrectores pilorum, hair
Uprightly, vegetative nerve or nervous centralis function get muddled, and hair follicle papilla changes and malnutrition, so as to cause hair
Function inhibitio is grown, hair enters stand-down and alopecia occurs；
2. trophism alopecia
Hair is the external manifestation of physical condition, and body malnutrition and pathobolism can cause hair quality and color development
Change, severe malnutrition even results in alopecia generalisata；
3. physical alopecia
The common physical factor for causing alopecia includes mechanical irritation and contact radioactive substance.
Kajiura Y,Watanabe S,Itou T.Structural analysis of human hair single
Mono- text of fbres by scanning microbeam SAXS.Struct.Biol.2006,155,438-444. confirms people's
The ingredient of hair 90% is keratin, wherein disulfide bond rich in, however disulfide bond is easy to during solarization, boiling hot dye
It is destroyed, so as to cause alopecia.Though external albumen can theoretically replace impaired albumen in the actual process
It is difficult to realize, because the isoelectric point for forming disulfide bond and foreign protein with keratin has certain requirement.
Chéret,Jérémy,Bertolini M,Ponce L,et al.Olfactory receptor
Mono- text report of OR2AT4regulates human hair growth [J] .Nature Communications, 2018,9 (1)
There is also the olfactory receptor of entitled OR2AT4 a kind of in human hair follicle, as OR2AT4 and a kind of specific scent --- sandenol
Molecular structure contact when, the result is that: it can stimulate natural on-off cycles of hair growth.However such compound is difficult the stabilization in shampoo and deposits
?.
Summary of the invention
Since above-mentioned deficiency exists in the prior art, the present invention provides a kind of Hair-loss-preventingshampoo shampoo and preparation method thereof,
Contain alopecia from number of ways.On the one hand the angle egg of hair supplement hair loss is given using the Plant glycoprotein of cationization
It is white, prevent its alopecia due to subalimentation；On the other hand, the Anti-hair loss factor has been used, in order to play its work on to greatest extent
With having carried out further screening on the basis of existing literature has the compound of Anti-hair loss effect, and is further processed
Stabilization energy can be kept preferably to be absorbed by human body.
Specifically, the present invention is achieved through the following technical solutions:
A kind of Hair-loss-preventingshampoo shampoo, including cationization Plant glycoprotein；
The preparation method of the cationization Plant glycoprotein includes the following steps:
1-2 part Plant glycoprotein by weight is added to 1.5-3.5 parts of 20-40wt% glycidyl alkyl-dimethyls
In ammonium chloride aqueous solution, stirring to pH value it is constant after be warming up to 50-55 DEG C of stirring 2-3 hours, addition lactic acid regulation system pH
To 4-5, the ethyl alcohol of system volume 30-50% is added, there is Precipitation, filter, take solid, freeze-drying to get.
Preferably, the preparation method of the Plant glycoprotein includes the following steps:
S1,1-2 part plant by weight is crushed, 2-6 times of petroleum ether is added, stirred 0.5-3 hours, filtering takes
Solid obtains defatted vegetable powder；
S2, by 1-2 part defatted vegetable powder by weight, 0.5-1.2 parts of 0.10-0.20mol/L sodium chloride water are added
Solution and 1.5-4.8 parts of 0.001-0.005mol/L PBS buffer solution, are centrifuged at 0-5 DEG C, take supernatant, add under ice-water bath
Enter the 0.7-0.75g/mL ammonium sulfate solution of supernatant volume 40-60%, stirred 1-3 hours at 5-10 DEG C, at 0-5 DEG C from
The heart takes solid to get Plant glycoprotein.
Preferably, the glycidyl tri alkyl ammomium chloride is glycidyl dodecyl dimethyl ammonium chloride.
Preferably, any one of the plant in arabidopsis leaf, tealeaves, perilla leaf or pumpkin.
It preferably, further include the Anti-hair loss factor；
The Anti-hair loss factor is
And/orThe R is H or methyl.
Preferably, the Hair-loss-preventingshampoo shampoo further includes the Anti-hair loss factor of metal-chelating；
The preparation method of the Anti-hair loss factor of the metal-chelating includes the following steps:
0.2-0.5 part Anti-hair loss factor, 0.02-0.05 parts of dopamines and 5-10 parts of tetrahydrofurans by weight are added
Enter into 20-30 portions of Tris-HCl buffers, after stirring 3-5 hours, A and 0.03-0.1 parts of nothings of 0.3-1.0 parts of inorganic salts are added
Machine salt B is stirred 4-8 hours at 5-15 DEG C, revolving remove tetrahydrofuran to get；
Any one of the inorganic salts A in ferrous sulfate, ferric sulfate, aluminium chloride or aluminum aluminum sulfate；
Any one of the inorganic salts B in platinum chloride, ruthenic chloride, iridium chloride or palladium chloride；
The Anti-hair loss factor is
And/orThe R is H or methyl.
Preferably, a kind of Hair-loss-preventingshampoo shampoo, raw material include 0.05-0.1 part citric acid by weight, 15-22 parts
Emulsifier, 1-4 part Cocoamidopropyl betaine, 1-4 parts of coconut oil fatty acid monoethanolamides, 0.5-1.0 parts of octadecanols,
1-2 portions of pearling agents, 0.05-0.1 parts of Anti-hair loss additives, 0.5-1.0 parts of cationization Plant glycoproteins and 70-75 parts of water；
The Anti-hair loss additive is selected from the Anti-hair loss factor of the Anti-hair loss factor or metal-chelating.
Preferably, the emulsifier in gum arabic, polyglucose, saponarin or lecithin any one or
It is a variety of.
Preferably, the preparation method of the polyglucose, includes the following steps:
S1, it takes 1-2 part peeling grape to be by weight added in 5-10 parts of water, flows back 1-5 hours, be concentrated into volume
To the 30-50% of volume at the end of reflux, 3-5 part ethyl alcohol are added, stand 12-24 hour, filter, take solid, 60 DEG C -70 DEG C are done
It is dry, obtain Thick many candies；
S2,1-2 part Thick many candies by weight are dissolved in 2-5 parts of water, 1-2 parts of Sevage reagents is added, vibrate 10-
30 minutes, centrifugation took supernatant, obtains centrifugate；
By n-butanol and chloroform, 1:4 is formulated the Sevage reagent by volume；
S3,3-5 parts of ethyl alcohol being added in 1-2 part centrifugate based on parts by volume, stands 8-16 hours, filtering takes solid,
At 60-70 DEG C dry to get.
Preferably, the polyglucose is V. amurensis polysaccharide.
Preferably, the emulsifier is made of 1-3 part V. amurensis polysaccharide by weight with 0.5-2 parts of lecithin.
A kind of preparation method of Hair-loss-preventingshampoo shampoo, includes the following steps:
By citric acid, emulsifier, Cocoamidopropyl betaine, coconut oil fatty acid monoethanolamide, octadecanol, pearl
Photo etching, Anti-hair loss additive, cationization Plant glycoprotein and water mixing, pass through high pressure Microfluidizer, pressure 200-
680atm, flow 150-250mL/min add up by 1-3 times to get Hair-loss-preventingshampoo shampoo.
The invention has the beneficial effects that: the Plant glycoprotein of cationization has been used, has promoted Plant glycoprotein that can glue
It is attached on hair and forms more disulfide bond, prevent hair loss；The Anti-hair loss factor is also used, the prior art has confirmed that such
The migration and proliferation that compound can promote human body exocuticle cutin to be formed, can also generate higher concentration in hair external root sheath
IGF-1, the present invention can be applied by metal-chelating mode in shampoo, select molysite or aluminium salt and anticreep
The hydroxyl complexing of the factor is sent out, while adding suitable dopamine to enhance its stability, the transition metal salt complexing of catalytic amount is added
The cyclic annular double bond of the Anti-hair loss factor, reduces its volatility.Finally by select suitable various surfactants, emulsifier and its
His auxiliary agent makes core of the invention ingredient can be good at being applied in shampoo, with long-time stability and excellent anti-
Alopecia effect.
Specific embodiment
The present invention is further elaborated on With reference to embodiment, following embodiments are only used to explain
The present invention cannot be considered as to further limitation of the invention.
Specifically, raw material sources used in following embodiments are as follows:
Pearling agent uses ethylene glycol double stearate, the production of Guangzhou Nan Jia Chemical Industry Science Co., Ltd.
Gum arabic, the E414 type arabia gum of Xi'an Mu Sen bioengineering Co., Ltd production, food-grade.
Lecithin is extracted from egg, is purchased from lark prestige scientific & technical corporation.
Pumpkin, Classification system are Cucurbita moschata (Duch.ex Lam.) Duch.ex Poiret..
Arabidopsis, Classification system are Arabidopsis thaliana..
Purple perilla, Classification system are Perilla frutescens (L.) Britt..
V. amurensis, Classification system are Vitis amurensis Rupr..
Embodiment 1
A kind of Hair-loss-preventingshampoo shampoo, raw material is by 0.075 part of citric acid, 20 parts of gum arabics, 2 portions of coconut palms by weight
Oleamide propyl betaine, 2 parts of coconut oil fatty acid monoethanolamides, 0.8 part of octadecanol, 1.2 portions of pearling agents, 0.08 part of gold
Belong to the Anti-hair loss factor, 0.7 part of cationization Plant glycoprotein and the 70 parts of deionized water compositions of chelating；
The cationization Plant glycoprotein the preparation method comprises the following steps:
1 part of pumpkin glycoprotein by weight is added to 2 parts of 30wt% glycidyl dodecyl dimethyl chlorine
Change in aqueous ammonium, stirring to pH value it is constant after be warming up to 60 DEG C, 300rpm is stirred 2 hours, and lactic acid regulation system pH is added extremely
5, the ethyl alcohol of system volume 40% is added, there is Precipitation, crosses 1000 meshes, takes solid, -30 DEG C/50Pa is freeze-dried, i.e.,
?；
The pumpkin glycoprotein the preparation method is as follows:
S1,1 part of pumpkin by weight is crushed, crosses 50 meshes, 4 times of petroleum ethers are added, 300rpm stirring 2 is small
When, it sieves with 100 mesh sieve, takes solid, obtain defatted vegetable powder；
S2, by 1 part of defatted vegetable powder by weight, 0.8 part of 0.20mol/L sodium-chloride water solution and 3.2 parts are added
0.004mol/L PBS buffer solution, 3000rpm is centrifuged 20 minutes at 4 DEG C, takes supernatant, supernatant fluid is added under ice-water bath
50% 0.75g/mL ammonium sulfate solution is accumulated, 300rpm is stirred 2 hours at 6 DEG C, and 5000rpm is centrifuged 20 minutes at 4 DEG C, is taken
Solid is to get pumpkin glycoprotein.
The Anti-hair loss factor of the metal-chelating the preparation method is as follows:
0.3 part of Anti-hair loss factor, 0.03 part of dopamine and 5 parts of tetrahydrofurans by weight are added to 25 parts of pH=
In 8.1 Tris-HCl buffer, after 500rpm is stirred 4 hours, it is added 0.5 part of ferrous sulfate and 0.05 part of iridium chloride, 10 DEG C
Lower 500rpm is stirred 8 hours, revolving remove tetrahydrofuran to get；
The Anti-hair loss factor structure formula is
The preparation method of above-mentioned Hair-loss-preventingshampoo shampoo, steps are as follows:
By citric acid, gum arabic, Cocoamidopropyl betaine, coconut oil fatty acid monoethanolamide, octadecane
Alcohol, pearling agent, Anti-hair loss additive, cationization Plant glycoprotein and deionized water mixing, by high pressure Microfluidizer,
Pressure is 400atm, flow 155mL/min, is added up by 3 times to get Hair-loss-preventingshampoo shampoo.
Embodiment 2
A kind of Hair-loss-preventingshampoo shampoo, raw material is by 0.075 part of citric acid, 20 parts of gum arabics, 2 portions of coconut palms by weight
Oleamide propyl betaine, 2 parts of coconut oil fatty acid monoethanolamides, 0.8 part of octadecanol, 1.2 portions of pearling agents, 0.08 part of gold
Belong to the Anti-hair loss factor, 0.7 part of cationization Plant glycoprotein and the 70 parts of deionized water compositions of chelating；
The cationization Plant glycoprotein the preparation method comprises the following steps:
1 part of arabidopsis leaf glycoprotein by weight is added to 2 parts of 30wt% glycidyl dodecyl dimethyls
In aqueous ammonium chloride solution, stirring to pH value it is constant after be warming up to 60 DEG C, 300rpm is stirred 2 hours, and lactic acid regulation system pH is added
To 5, the ethyl alcohol of system volume 40% is added, there is Precipitation, crosses 1000 meshes, takes solid, -30 DEG C/50Pa is freeze-dried, i.e.,
?；
The arabidopsis leaf glycoprotein the preparation method is as follows:
S1,1 part of arabidopsis leaf by weight is crushed, crosses 50 meshes, 4 times of petroleum ethers are added, 300rpm stirring 2 is small
When, it sieves with 100 mesh sieve, takes solid, obtain defatted vegetable powder；
S2, by 1 part of defatted vegetable powder by weight, 0.5 part of 0.20mol/L sodium-chloride water solution and 3.5 parts are added
0.004mol/L PBS buffer solution, 3000rpm is centrifuged 20 minutes at 4 DEG C, takes supernatant, supernatant fluid is added under ice-water bath
50% 0.75g/mL ammonium sulfate solution is accumulated, 300rpm is stirred 2 hours at 6 DEG C, and 5000rpm is centrifuged 20 minutes at 4 DEG C, is taken
Solid is to get arabidopsis leaf glycoprotein.
The Anti-hair loss factor of the metal-chelating the preparation method is as follows:
0.3 part of Anti-hair loss factor, 0.03 part of dopamine and 5 parts of tetrahydrofurans by weight are added to 25 parts of pH=
In 8.1 Tris-HCl buffer, after 500rpm is stirred 4 hours, it is added 0.5 part of ferrous sulfate and 0.05 part of iridium chloride, 10 DEG C
Lower 500rpm is stirred 8 hours, revolving remove tetrahydrofuran to get；
The Anti-hair loss factor structure formula is
The preparation method of above-mentioned Hair-loss-preventingshampoo shampoo, steps are as follows:
By citric acid, gum arabic, Cocoamidopropyl betaine, coconut oil fatty acid monoethanolamide, octadecane
Alcohol, pearling agent, Anti-hair loss additive, cationization Plant glycoprotein and deionized water mixing, by high pressure Microfluidizer,
Pressure is 400atm, flow 155mL/min, is added up by 3 times to get Hair-loss-preventingshampoo shampoo.
Embodiment 3
A kind of Hair-loss-preventingshampoo shampoo, raw material is by 0.075 part of citric acid, 20 parts of gum arabics, 2 portions of coconut palms by weight
Oleamide propyl betaine, 2 parts of coconut oil fatty acid monoethanolamides, 0.8 part of octadecanol, 1.2 portions of pearling agents, 0.08 part of gold
Belong to the Anti-hair loss factor, 0.7 part of cationization Plant glycoprotein and the 70 parts of deionized water compositions of chelating；
The cationization Plant glycoprotein the preparation method comprises the following steps:
1 part of perilla leaf glycoprotein by weight is added to 2 parts of 30wt% glycidyl dodecyl dimethyl chlorine
Change in aqueous ammonium, stirring to pH value it is constant after be warming up to 60 DEG C, 300rpm is stirred 2 hours, and lactic acid regulation system pH is added extremely
5, the ethyl alcohol of system volume 40% is added, there is Precipitation, crosses 1000 meshes, takes solid, -30 DEG C/50Pa is freeze-dried, i.e.,
?；
The perilla leaf glycoprotein the preparation method is as follows:
S1,1 part of perilla leaf by weight is crushed, crosses 50 meshes, 4 times of petroleum ethers are added, 300rpm stirring 2 is small
When, it sieves with 100 mesh sieve, takes solid, obtain defatted vegetable powder；
S2, by 1 part of defatted vegetable powder by weight, 0.8 part of 0.17mol/L sodium-chloride water solution and 3.0 parts are added
0.004mol/L PBS buffer solution, 3000rpm is centrifuged 20 minutes at 4 DEG C, takes supernatant, supernatant fluid is added under ice-water bath
45% 0.75g/mL ammonium sulfate solution is accumulated, 300rpm is stirred 2 hours at 6 DEG C, and 5000rpm is centrifuged 20 minutes at 4 DEG C, is taken
Solid is to get perilla leaf glycoprotein.
The Anti-hair loss factor of the metal-chelating the preparation method is as follows:
0.3 part of Anti-hair loss factor, 0.03 part of dopamine and 5 parts of tetrahydrofurans by weight are added to 25 parts of pH=
In 8.1 Tris-HCl buffer, after 500rpm is stirred 4 hours, it is added 0.5 part of ferrous sulfate and 0.05 part of iridium chloride, 10 DEG C
Lower 500rpm is stirred 8 hours, revolving remove tetrahydrofuran to get；
The Anti-hair loss factor structure formula is
The preparation method of above-mentioned Hair-loss-preventingshampoo shampoo, steps are as follows:
By citric acid, gum arabic, Cocoamidopropyl betaine, coconut oil fatty acid monoethanolamide, octadecane
Alcohol, pearling agent, Anti-hair loss additive, cationization Plant glycoprotein and deionized water mixing, by high pressure Microfluidizer,
Pressure is 400atm, flow 155mL/min, is added up by 3 times to get Hair-loss-preventingshampoo shampoo.
Embodiment 4
A kind of Hair-loss-preventingshampoo shampoo, raw material is by 0.075 part of citric acid, 20 parts of gum arabics, 2 portions of coconut palms by weight
Oleamide propyl betaine, 2 parts of coconut oil fatty acid monoethanolamides, 0.8 part of octadecanol, 1.2 portions of pearling agents, 0.08 part of gold
Belong to the Anti-hair loss factor, 0.7 part of cationization Plant glycoprotein and the 70 parts of deionized water compositions of chelating；
The cationization Plant glycoprotein the preparation method comprises the following steps:
1 part of perilla leaf glycoprotein by weight is added to 2 parts of 30wt% glycidyl dodecyl dimethyl chlorine
Change in aqueous ammonium, stirring to pH value it is constant after be warming up to 60 DEG C, 300rpm is stirred 2 hours, and lactic acid regulation system pH is added extremely
5, the ethyl alcohol of system volume 40% is added, there is Precipitation, crosses 1000 meshes, takes solid, -30 DEG C/50Pa is freeze-dried, i.e.,
?；
The perilla leaf glycoprotein the preparation method is as follows:
S1,1 part of perilla leaf by weight is crushed, crosses 50 meshes, 4 times of petroleum ethers are added, 300rpm stirring 2 is small
When, it sieves with 100 mesh sieve, takes solid, obtain defatted vegetable powder；
S2, by 1 part of defatted vegetable powder by weight, 0.8 part of 0.17mol/L sodium-chloride water solution and 3.0 parts are added
0.004mol/L PBS buffer solution, 3000rpm is centrifuged 20 minutes at 4 DEG C, takes supernatant, supernatant fluid is added under ice-water bath
45% 0.75g/mL ammonium sulfate solution is accumulated, 300rpm is stirred 2 hours at 6 DEG C, and 5000rpm is centrifuged 20 minutes at 4 DEG C, is taken
Solid is to get perilla leaf glycoprotein.
The Anti-hair loss factor of the metal-chelating the preparation method is as follows:
0.3 part of Anti-hair loss factor, 0.03 part of dopamine and 5 parts of tetrahydrofurans by weight are added to 25 parts of pH=
In 8.1 Tris-HCl buffer, after 500rpm is stirred 4 hours, it is added 0.5 part of ferrous sulfate and 0.05 part of platinum chloride, 10 DEG C
Lower 500rpm is stirred 8 hours, revolving remove tetrahydrofuran to get；
The Anti-hair loss factor structure formula is
The preparation method of above-mentioned Hair-loss-preventingshampoo shampoo, steps are as follows:
By citric acid, gum arabic, Cocoamidopropyl betaine, coconut oil fatty acid monoethanolamide, octadecane
Alcohol, pearling agent, Anti-hair loss additive, cationization Plant glycoprotein and deionized water mixing, by high pressure Microfluidizer,
Pressure is 400atm, flow 155mL/min, is added up by 3 times to get Hair-loss-preventingshampoo shampoo.
Embodiment 5
A kind of Hair-loss-preventingshampoo shampoo, raw material is by 0.075 part of citric acid, 20 parts of gum arabics, 2 portions of coconut palms by weight
Oleamide propyl betaine, 2 parts of coconut oil fatty acid monoethanolamides, 0.8 part of octadecanol, 1.2 portions of pearling agents, 0.08 part of gold
Belong to the Anti-hair loss factor, 0.7 part of cationization Plant glycoprotein and the 70 parts of deionized water compositions of chelating；
The cationization Plant glycoprotein the preparation method comprises the following steps:
1 part of perilla leaf glycoprotein by weight is added to 2 parts of 30wt% glycidyl dodecyl dimethyl chlorine
Change in aqueous ammonium, stirring to pH value it is constant after be warming up to 60 DEG C, 300rpm is stirred 2 hours, and lactic acid regulation system pH is added extremely
5, the ethyl alcohol of system volume 40% is added, there is Precipitation, crosses 1000 meshes, takes solid, -30 DEG C/50Pa is freeze-dried, i.e.,
?；
The perilla leaf glycoprotein the preparation method is as follows:
S1,1 part of perilla leaf by weight is crushed, crosses 50 meshes, 4 times of petroleum ethers are added, 300rpm stirring 2 is small
When, it sieves with 100 mesh sieve, takes solid, obtain defatted vegetable powder；
S2, by 1 part of defatted vegetable powder by weight, 0.8 part of 0.17mol/L sodium-chloride water solution and 3.0 parts are added
0.004mol/L PBS buffer solution, 3000rpm is centrifuged 20 minutes at 4 DEG C, takes supernatant, supernatant fluid is added under ice-water bath
45% 0.75g/mL ammonium sulfate solution is accumulated, 300rpm is stirred 2 hours at 6 DEG C, and 5000rpm is centrifuged 20 minutes at 4 DEG C, is taken
Solid is to get perilla leaf glycoprotein.
The Anti-hair loss factor of the metal-chelating the preparation method is as follows:
0.3 part of Anti-hair loss factor, 0.03 part of dopamine and 5 parts of tetrahydrofurans by weight are added to 25 parts of pH=
In 8.1 Tris-HCl buffer, after 500rpm is stirred 4 hours, it is added 0.5 part of aluminum aluminum sulfate and 0.05 part of platinum chloride, 10 DEG C
Lower 500rpm is stirred 8 hours, revolving remove tetrahydrofuran to get；
The Anti-hair loss factor structure formula is
The preparation method of above-mentioned Hair-loss-preventingshampoo shampoo, steps are as follows:
By citric acid, gum arabic, Cocoamidopropyl betaine, coconut oil fatty acid monoethanolamide, octadecane
Alcohol, pearling agent, Anti-hair loss additive, cationization Plant glycoprotein and deionized water mixing, by high pressure Microfluidizer,
Pressure is 400atm, flow 155mL/min, is added up by 3 times to get Hair-loss-preventingshampoo shampoo.
Embodiment 6
A kind of Hair-loss-preventingshampoo shampoo, raw material is by 0.075 part of citric acid, 20 parts of lecithin, 2 parts of cocounut oil acyls by weight
Amine propyl betaine, 2 parts of coconut oil fatty acid monoethanolamides, 0.8 part of octadecanol, 1.2 portions of pearling agents, 0.08 part of metal chelating
The Anti-hair loss factor of conjunction, 0.7 part of cationization Plant glycoprotein and 70 parts of deionized water compositions；
The cationization Plant glycoprotein the preparation method comprises the following steps:
1 part of perilla leaf glycoprotein by weight is added to 2 parts of 30wt% glycidyl dodecyl dimethyl chlorine
Change in aqueous ammonium, stirring to pH value it is constant after be warming up to 60 DEG C, 300rpm is stirred 2 hours, and lactic acid regulation system pH is added extremely
5, the ethyl alcohol of system volume 40% is added, there is Precipitation, crosses 1000 meshes, takes solid, -30 DEG C/50Pa is freeze-dried, i.e.,
?；
The perilla leaf glycoprotein the preparation method is as follows:
S1,1 part of perilla leaf by weight is crushed, crosses 50 meshes, 4 times of petroleum ethers are added, 300rpm stirring 2 is small
When, it sieves with 100 mesh sieve, takes solid, obtain defatted vegetable powder；
S2, by 1 part of defatted vegetable powder by weight, 0.8 part of 0.17mol/L sodium-chloride water solution and 3.0 parts are added
0.004mol/L PBS buffer solution, 3000rpm is centrifuged 20 minutes at 4 DEG C, takes supernatant, supernatant fluid is added under ice-water bath
45% 0.75g/mL ammonium sulfate solution is accumulated, 300rpm is stirred 2 hours at 6 DEG C, and 5000rpm is centrifuged 20 minutes at 4 DEG C, is taken
Solid is to get perilla leaf glycoprotein.
The Anti-hair loss factor of the metal-chelating the preparation method is as follows:
0.3 part of Anti-hair loss factor, 0.03 part of dopamine and 5 parts of tetrahydrofurans by weight are added to 25 parts of pH=
In 8.1 Tris-HCl buffer, after 500rpm is stirred 4 hours, it is added 0.5 part of aluminum aluminum sulfate and 0.05 part of platinum chloride, 10 DEG C
Lower 500rpm is stirred 8 hours, revolving remove tetrahydrofuran to get；
The Anti-hair loss factor structure formula is
The preparation method of above-mentioned Hair-loss-preventingshampoo shampoo, steps are as follows:
By citric acid, lecithin, Cocoamidopropyl betaine, coconut oil fatty acid monoethanolamide, octadecanol, pearl
Photo etching, Anti-hair loss additive, cationization Plant glycoprotein and deionized water mixing, pass through high pressure Microfluidizer, pressure
For 400atm, flow 155mL/min, add up by 3 times to get Hair-loss-preventingshampoo shampoo.
Embodiment 7
A kind of Hair-loss-preventingshampoo shampoo, raw material is by 0.075 part of citric acid, 20 parts of V. amurensis polysaccharide, 2 portions of coconut palms by weight
Oleamide propyl betaine, 2 parts of coconut oil fatty acid monoethanolamides, 0.8 part of octadecanol, 1.2 portions of pearling agents, 0.08 part of gold
Belong to the Anti-hair loss factor, 0.7 part of cationization Plant glycoprotein and the 70 parts of deionized water compositions of chelating；
The cationization Plant glycoprotein the preparation method comprises the following steps:
1 part of perilla leaf glycoprotein by weight is added to 2 parts of 30wt% glycidyl dodecyl dimethyl chlorine
Change in aqueous ammonium, stirring to pH value it is constant after be warming up to 60 DEG C, 300rpm is stirred 2 hours, and lactic acid regulation system pH is added extremely
5, the ethyl alcohol of system volume 40% is added, there is Precipitation, crosses 1000 meshes, takes solid, -30 DEG C/50Pa is freeze-dried, i.e.,
?；
The perilla leaf glycoprotein the preparation method is as follows:
S1,1 part of perilla leaf by weight is crushed, crosses 50 meshes, 4 times of petroleum ethers are added, 300rpm stirring 2 is small
When, it sieves with 100 mesh sieve, takes solid, obtain defatted vegetable powder；
S2, by 1 part of defatted vegetable powder by weight, 0.8 part of 0.17mol/L sodium-chloride water solution and 3.0 parts are added
0.004mol/L PBS buffer solution, 3000rpm is centrifuged 20 minutes at 4 DEG C, takes supernatant, supernatant fluid is added under ice-water bath
45% 0.75g/mL ammonium sulfate solution is accumulated, 300rpm is stirred 2 hours at 6 DEG C, and 5000rpm is centrifuged 20 minutes at 4 DEG C, is taken
Solid is to get perilla leaf glycoprotein.
The Anti-hair loss factor of the metal-chelating the preparation method is as follows:
0.3 part of Anti-hair loss factor, 0.03 part of dopamine and 5 parts of tetrahydrofurans by weight are added to 25 parts of pH=
In 8.1 Tris-HCl buffer, after 500rpm is stirred 4 hours, it is added 0.5 part of aluminum aluminum sulfate and 0.05 part of platinum chloride, 10 DEG C
Lower 500rpm is stirred 8 hours, revolving remove tetrahydrofuran to get；
The Anti-hair loss factor structure formula is
The V. amurensis polysaccharide the preparation method is as follows:
S1,1 part of peeling V. amurensis by weight is taken to be added in 8 parts of water, 110 DEG C are flowed back 3 hours, and volume is concentrated into
To 45% of volume at the end of reflux, 3 parts of ethyl alcohol are added, stands 12 hours, sieves with 100 mesh sieve, take solid, 60 DEG C drying 8 hours,
Obtain Thick many candies；
S2,1 part of Thick many candies by weight are dissolved in 3 parts of water, 1.2 parts of Sevage reagents are added, vibrated 20 minutes,
3000rpm is centrifuged 10 minutes, is taken supernatant, is obtained centrifugate；
By n-butanol and chloroform, 1:4 is formulated the Sevage reagent by volume；
S3,4 parts of ethyl alcohol will be added in 1 part of centrifugate based on parts by volume, stand 12 hours, cross 300 meshes, take solid,
At 60 DEG C dry 8 hours to get.
The preparation method of above-mentioned Hair-loss-preventingshampoo shampoo, steps are as follows:
By citric acid, V. amurensis polysaccharide, Cocoamidopropyl betaine, coconut oil fatty acid monoethanolamide, octadecane
Alcohol, pearling agent, Anti-hair loss additive, cationization Plant glycoprotein and deionized water mixing, by high pressure Microfluidizer,
Pressure is 400atm, flow 155mL/min, is added up by 3 times to get Hair-loss-preventingshampoo shampoo.
Embodiment 8
A kind of Hair-loss-preventingshampoo shampoo, raw material is by 0.075 part of citric acid, 16 parts of gum arabics, 4 parts of ovum by weight
Phosphatide, 2 parts of Cocoamidopropyl betaines, 2 parts of coconut oil fatty acid monoethanolamides, 0.8 part of octadecanol, 1.2 parts of pearly-lustres
Agent, the Anti-hair loss factor of 0.08 part of metal-chelating, 0.7 part of cationization Plant glycoprotein and 70 parts of deionized waters compositions；
The cationization Plant glycoprotein the preparation method comprises the following steps:
1 part of perilla leaf glycoprotein by weight is added to 2 parts of 30wt% glycidyl dodecyl dimethyl chlorine
Change in aqueous ammonium, stirring to pH value it is constant after be warming up to 60 DEG C, 300rpm is stirred 2 hours, and lactic acid regulation system pH is added extremely
5, the ethyl alcohol of system volume 40% is added, there is Precipitation, crosses 1000 meshes, takes solid, -30 DEG C/50Pa is freeze-dried, i.e.,
?；
The perilla leaf glycoprotein the preparation method is as follows:
S1,1 part of perilla leaf by weight is crushed, crosses 50 meshes, 4 times of petroleum ethers are added, 300rpm stirring 2 is small
When, it sieves with 100 mesh sieve, takes solid, obtain defatted vegetable powder；
S2, by 1 part of defatted vegetable powder by weight, 0.8 part of 0.17mol/L sodium-chloride water solution and 3.0 parts are added
0.004mol/L PBS buffer solution, 3000rpm is centrifuged 20 minutes at 4 DEG C, takes supernatant, supernatant fluid is added under ice-water bath
45% 0.75g/mL ammonium sulfate solution is accumulated, 300rpm is stirred 2 hours at 6 DEG C, and 5000rpm is centrifuged 20 minutes at 4 DEG C, is taken
Solid is to get perilla leaf glycoprotein.
The Anti-hair loss factor of the metal-chelating the preparation method is as follows:
0.3 part of Anti-hair loss factor, 0.03 part of dopamine and 5 parts of tetrahydrofurans by weight are added to 25 parts of pH=
In 8.1 Tris-HCl buffer, after 500rpm is stirred 4 hours, it is added 0.5 part of aluminum aluminum sulfate and 0.05 part of platinum chloride, 10 DEG C
Lower 500rpm is stirred 8 hours, revolving remove tetrahydrofuran to get；
The Anti-hair loss factor structure formula is
The preparation method of above-mentioned Hair-loss-preventingshampoo shampoo, steps are as follows:
By citric acid, gum arabic, lecithin, Cocoamidopropyl betaine, coconut oil fatty acid monoethanolamide,
Octadecanol, pearling agent, Anti-hair loss additive, cationization Plant glycoprotein and deionized water mixing, pass through high pressure microjet
Homogenizer, pressure 400atm, flow 155mL/min add up by 3 times to get Hair-loss-preventingshampoo shampoo.
Embodiment 9
A kind of Hair-loss-preventingshampoo shampoo, raw material is by 0.075 part of citric acid, 16 parts of V. amurensis polysaccharide, 4 parts of ovum by weight
Phosphatide, 2 parts of Cocoamidopropyl betaines, 2 parts of coconut oil fatty acid monoethanolamides, 0.8 part of octadecanol, 1.2 parts of pearly-lustres
Agent, the Anti-hair loss factor of 0.08 part of metal-chelating, 0.7 part of cationization Plant glycoprotein and 70 parts of deionized waters compositions；
The cationization Plant glycoprotein the preparation method comprises the following steps:
1 part of perilla leaf glycoprotein by weight is added to 2 parts of 30wt% glycidyl dodecyl dimethyl chlorine
Change in aqueous ammonium, stirring to pH value it is constant after be warming up to 60 DEG C, 300rpm is stirred 2 hours, and lactic acid regulation system pH is added extremely
5, the ethyl alcohol of system volume 40% is added, there is Precipitation, crosses 1000 meshes, takes solid, -30 DEG C/50Pa is freeze-dried, i.e.,
?；
The perilla leaf glycoprotein the preparation method is as follows:
S1,1 part of perilla leaf by weight is crushed, crosses 50 meshes, 4 times of petroleum ethers are added, 300rpm stirring 2 is small
When, it sieves with 100 mesh sieve, takes solid, obtain defatted vegetable powder；
S2, by 1 part of defatted vegetable powder by weight, 0.8 part of 0.17mol/L sodium-chloride water solution and 3.0 parts are added
0.004mol/L PBS buffer solution, 3000rpm is centrifuged 20 minutes at 4 DEG C, takes supernatant, supernatant fluid is added under ice-water bath
45% 0.75g/mL ammonium sulfate solution is accumulated, 300rpm is stirred 2 hours at 6 DEG C, and 5000rpm is centrifuged 20 minutes at 4 DEG C, is taken
Solid is to get perilla leaf glycoprotein.
The Anti-hair loss factor of the metal-chelating the preparation method is as follows:
0.3 part of Anti-hair loss factor, 0.03 part of dopamine and 5 parts of tetrahydrofurans by weight are added to 25 parts of pH=
In 8.1 Tris-HCl buffer, after 500rpm is stirred 4 hours, it is added 0.5 part of aluminum aluminum sulfate and 0.05 part of platinum chloride, 10 DEG C
Lower 500rpm is stirred 8 hours, revolving remove tetrahydrofuran to get；
The Anti-hair loss factor structure formula is
The V. amurensis polysaccharide the preparation method is as follows:
S1,1 part of peeling V. amurensis by weight is taken to be added in 8 parts of water, 110 DEG C are flowed back 3 hours, and volume is concentrated into
To 45% of volume at the end of reflux, 3 parts of ethyl alcohol are added, stands 12 hours, sieves with 100 mesh sieve, take solid, 60 DEG C drying 8 hours,
Obtain Thick many candies；
S2,1 part of Thick many candies by weight are dissolved in 3 parts of water, 1.2 parts of Sevage reagents are added, vibrated 20 minutes,
3000rpm is centrifuged 10 minutes, is taken supernatant, is obtained centrifugate；
By n-butanol and chloroform, 1:4 is formulated the Sevage reagent by volume；
S3,4 parts of ethyl alcohol will be added in 1 part of centrifugate based on parts by volume, stand 12 hours, cross 300 meshes, take solid,
At 60 DEG C dry 8 hours to get.
The preparation method of above-mentioned Hair-loss-preventingshampoo shampoo, steps are as follows:
By citric acid, V. amurensis polysaccharide, lecithin, Cocoamidopropyl betaine, coconut oil fatty acid monoethanolamide,
Octadecanol, pearling agent, Anti-hair loss additive, cationization Plant glycoprotein and deionized water mixing, pass through high pressure microjet
Homogenizer, pressure 400atm, flow 155mL/min add up by 3 times to get Hair-loss-preventingshampoo shampoo.
Test case 1
External hair follicle Anti-hair loss test
The porker pig ear of new slaughter is selected, corium and subcutaneous tissue is separated, then separate growth period hair follicle, is put into 24 orifice plates
In, every Kong Yigen, every hole WilliamsE containing 0.5mL serum free medium, 95% oxygen, 5% carbon dioxide, 38 DEG C of cultures, training
Select that form is intact, the similar hair follicle of the speed of growth is for testing after supporting 12 hours.
Test is divided into 10 groups, and every group of hair follicle using 10 growth periods, control group does not add any substance additionally, is used only
WilliamsE serum free medium culture.Test group is added respectively uses 1mol/L NaOH water in advance made from embodiment 1-9
Solution adjusts the Hair-loss-preventingshampoo shampoo of pH to 7.0, makes the concentration 20mg/mL of Hair-loss-preventingshampoo shampoo in the medium.
Respectively at first day of culture and the 7th day under inverted microscope, hair follicle bottom is measured by eyepiece mircrometer gauge and is arrived
The length on the hair crown, the result for measuring length twice are mutually kept to hair growth length, take 10 cell means.
Test result is as shown in table 1.
1 hair growth length of table
| Cultivate 7 days hair length/mm | |
| Reference examples | 1.730 |
| Embodiment 1 | 1.880 |
| Embodiment 2 | 1.925 |
| Embodiment 3 | 2.025 |
| Embodiment 4 | 2.015 |
| Embodiment 5 | 2.120 |
| Embodiment 6 | 2.085 |
| Embodiment 7 | 2.175 |
| Embodiment 8 | 2.145 |
| Embodiment 9 | 2.280 |
As seen from the above table, Hair-loss-preventingshampoo shampoo provided by the invention facilitates natural on-off cycles of hair growth, in optimal conditions, Ke Yi
2.3mm is grown after culture in 7 days.
Test case 2
Foamability test
Foamability test is carried out to Hair-loss-preventingshampoo shampoo made from embodiment 1-9, is measured using Roche foamer meter
Foam height.
Test result is as shown in table 2.
2 foamability of table
| Foamability/cm | |
| Embodiment 1 | 12.4 |
| Embodiment 2 | 13.3 |
| Embodiment 3 | 13.2 |
| Embodiment 4 | 13.5 |
| Embodiment 5 | 14.4 |
| Embodiment 6 | 13.2 |
| Embodiment 7 | 15.7 |
| Embodiment 8 | 14.4 |
| Embodiment 9 | 16.9 |
As seen from the above table, Hair-loss-preventingshampoo shampoo provided by the invention has good foamability, and wherein emulsifier plays it
Bubble ability has large effect, and when using V. amurensis polysaccharide, lecithin as emulsifier, bubbling ability is best.
Claims (10)
1. a kind of Hair-loss-preventingshampoo shampoo, which is characterized in that including the Plant glycoprotein that is cationized；
The preparation method of the cationization Plant glycoprotein includes the following steps:
1-2 part Plant glycoprotein by weight is added to 1.5-3.5 parts of 20-40wt% glycidyl tri alkyl ammomium chlorides
In aqueous solution, stirring to pH value it is constant after be warming up to 50-55 DEG C of stirring 2-3 hours, addition lactic acid regulation system pH to 4-5 adds
The ethyl alcohol for entering system volume 30-50% has Precipitation, and filtering takes solid, freeze-drying to get.
2. Hair-loss-preventingshampoo shampoo according to claim 1, which is characterized in that the preparation method of the Plant glycoprotein includes
Following step:
S1,1-2 part plant by weight being crushed, 2-6 times of petroleum ether is added, stirred 0.5-3 hours, filtering takes solid,
Obtain defatted vegetable powder；
S2, by 1-2 part defatted vegetable powder by weight, 0.5-1.2 parts of 0.10-0.20mol/L sodium-chloride water solutions are added
It with 1.5-4.8 parts of 0.001-0.005mol/L PBS buffer solution, is centrifuged at 0-5 DEG C, takes supernatant, be added under ice-water bath
The ammonium sulfate solution of the 0.7-0.75g/mL of supernatant volume 40-60% stirs 1-3 hours at 5-10 DEG C, at 0-5 DEG C from
The heart takes solid to get Plant glycoprotein.
3. Hair-loss-preventingshampoo shampoo according to claim 2, which is characterized in that the plant is selected from arabidopsis leaf, tealeaves, purple
Any one in perilla leaf or pumpkin.
4. Hair-loss-preventingshampoo shampoo according to claim 1, which is characterized in that further include the Anti-hair loss factor；
The Anti-hair loss factor is
And/orThe R is H or methyl.
5. Hair-loss-preventingshampoo shampoo according to claim 1, which is characterized in that further include the Anti-hair loss factor of metal-chelating；
The preparation method of the Anti-hair loss factor of the metal-chelating includes the following steps:
0.2-0.5 part Anti-hair loss factor, 0.02-0.05 parts of dopamines and 5-10 parts of tetrahydrofurans by weight are added to
In 20-30 portions of Tris-HCl buffers, after stirring 3-5 hours, A and 0.03-0.1 parts of inorganic salts of 0.3-1.0 parts of inorganic salts are added
Stirred 4-8 hours at B, 5-15 DEG C, revolving remove tetrahydrofuran to get；
Any one of the inorganic salts A in ferrous sulfate, ferric sulfate, aluminium chloride or aluminum aluminum sulfate；
Any one of the inorganic salts B in platinum chloride, ruthenic chloride, iridium chloride or palladium chloride；
The Anti-hair loss factor is
And/orThe R is H or methyl.
6. Hair-loss-preventingshampoo shampoo described in -5 any one according to claim 1, which is characterized in that raw material includes by weight
0.05-0.1 part citric acid, 15-22 parts of emulsifiers, 1-4 parts of Cocoamidopropyl betaines, 1-4 parts of coco-nut oil fatty acid lists
Glycollic amide, 0.5-1.0 part octadecanol, 1-2 portions of pearling agents, 0.05-0.1 parts of Anti-hair loss additives, 0.5-1.0 parts of cations
Change Plant glycoprotein and 70-75 parts of water；
The Anti-hair loss additive is selected from the Anti-hair loss factor of the Anti-hair loss factor or metal-chelating.
7. Hair-loss-preventingshampoo shampoo according to claim 6, which is characterized in that the emulsifier is selected from gum arabic, Portugal
Any one or more in grape polysaccharide, saponarin or lecithin.
8. Hair-loss-preventingshampoo shampoo according to claim 7, which is characterized in that the polyglucose is V. amurensis polysaccharide.
9. Hair-loss-preventingshampoo shampoo according to claim 7, which is characterized in that the emulsifier is by 1-3 by weight
Part V. amurensis polysaccharide is formed with 0.5-2 parts of lecithin.
10. the preparation method of Hair-loss-preventingshampoo shampoo described in claim 6-9 any one, which is characterized in that including following steps
It is rapid:
By citric acid, emulsifier, Cocoamidopropyl betaine, coconut oil fatty acid monoethanolamide, octadecanol, pearly-lustre
Agent, Anti-hair loss additive, cationization Plant glycoprotein and water mixing, pass through high pressure Microfluidizer, pressure 200-
680atm, flow 150-250mL/min add up by 1-3 times to get Hair-loss-preventingshampoo shampoo.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910825548.2A CN110354049A (en) | 2019-09-03 | 2019-09-03 | A kind of Hair-loss-preventingshampoo shampoo and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910825548.2A CN110354049A (en) | 2019-09-03 | 2019-09-03 | A kind of Hair-loss-preventingshampoo shampoo and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110354049A true CN110354049A (en) | 2019-10-22 |
Family
ID=68225476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910825548.2A Withdrawn CN110354049A (en) | 2019-09-03 | 2019-09-03 | A kind of Hair-loss-preventingshampoo shampoo and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110354049A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112656724A (en) * | 2020-12-29 | 2021-04-16 | 娇时日化（杭州）股份有限公司 | Shampoo and preparation method thereof |
| WO2023110582A1 (en) * | 2021-12-15 | 2023-06-22 | Kao Germany Gmbh | An aqueous composition for hair |
-
2019
- 2019-09-03 CN CN201910825548.2A patent/CN110354049A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112656724A (en) * | 2020-12-29 | 2021-04-16 | 娇时日化（杭州）股份有限公司 | Shampoo and preparation method thereof |
| WO2023110582A1 (en) * | 2021-12-15 | 2023-06-22 | Kao Germany Gmbh | An aqueous composition for hair |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110354049A (en) | A kind of Hair-loss-preventingshampoo shampoo and preparation method thereof | |
| EP0746308B1 (en) | Emulsions | |
| CN101039655A (en) | Hair care compositions | |
| DE102015223828A1 (en) | Powerful hair treatment with anti-washout effect | |
| CN107496296B (en) | Hair composition containing rice fermented product filtrate and preparation method thereof | |
| CN106924116A (en) | One plant tea bran shampoo and preparation method thereof | |
| CN106420524A (en) | Anti-hair-loss and hair-promotion traditional Chinese medicine composition as well as preparation method and application thereof | |
| DE4309568A1 (en) | Detergent mixtures with improved softening properties | |
| DE11151426T1 (en) | Genetically processed gelan | |
| CN110151615A (en) | A kind of amino acid shampoo and preparation method thereof of antiallergic anti-inflammatory | |
| DE19847276A1 (en) | Oxidative dyeing composition for keratin fibers, especially human hair, comprising dye precursor(s), choline-based oxidase system and peroxidase, giving good dyeings without damaging fibers or skin | |
| DE69626489T2 (en) | METHOD FOR PRODUCING BACTERIAL CELLULOSE | |
| CN109044857A (en) | A kind of no silicone oil shampoo conditioner composition, without silicone oil shampoo and preparation method thereof | |
| DE1949719C2 (en) | Microbiological production of dextranase | |
| CN101386644A (en) | Pumpkin protein 2 and preparation method and application thereof | |
| CN114306146A (en) | Shampoo containing combination of anti-dandruff and anti-hair loss active ingredients | |
| DE102015223835A1 (en) | Powerful hair treatment with anti-washout effect | |
| KR102131361B1 (en) | Cosmetic composition for hair and scalp comprising keratin peptides as active ingredients | |
| CN111233965A (en) | Glycyrrhetinic acid derivative LGT and preparation method and application thereof | |
| CN110151665A (en) | A kind of pearl bird's nest sleep mask and preparation method thereof | |
| CN108295007A (en) | A kind of active hair growth liquor and preparation method thereof containing ginger material liquid mixture | |
| Honomichl | Fine structure of a mandibular stretch receptor in Thrips physapus L.(Thysanoptera, Insecta) | |
| CN115992184B (en) | Biological fermentation surfactant, cosmetic and preparation method thereof | |
| CN108348433B (en) | Use of glycosides for increasing hair quality | |
| DE102014224771A1 (en) | Nourishing hair shampoo with flex control |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20191022 |
|
| WW01 | Invention patent application withdrawn after publication |